CuGenDBv2

Gene ID	CSPI03G43330
Organism	Cucumis sativus L. var. sativus cv. PI 183967 (Cucumber (PI 183967) v1)
Description	protein SPA, chloroplastic
Genome location	Chr3:37252677..37256061
RNA-Seq Expression	CSPI03G43330
Synteny	CSPI03G43330
Gene Ontology terms	GO:0010206 - photosystem II repair (biological process) GO:0009507 - chloroplast (cellular component) GO:0016021 - integral component of membrane (cellular component) GO:0003756 - protein disulfide isomerase activity (molecular function)
InterPro domains	IPR035272 - Protein of unknown function DUF5351 IPR036410 - Heat shock protein DnaJ, cysteine-rich domain superfamily

Homology

Show/hide homology

GenBank top hits

e value

%identity

Alignment

XP_004136388.1 protein disulfide-isomerase LQY1, chloroplastic [Cucumis sativus]

5.2e-86

100

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Query:  MTVAPSLSRLHSPFLYCPLKPTPSTSLSVTFSGNQRSPPSYPRIRAIDLDQNTVVALSVGLVSVAIGIGIPVFYETQIDNAAKRENTQPCFPCSGSGAQR
        MTVAPSLSRLHSPFLYCPLKPTPSTSLSVTFSGNQRSPPSYPRIRAIDLDQNTVVALSVGLVSVAIGIGIPVFYETQIDNAAKRENTQPCFPCSGSGAQR
Subjt:  MTVAPSLSRLHSPFLYCPLKPTPSTSLSVTFSGNQRSPPSYPRIRAIDLDQNTVVALSVGLVSVAIGIGIPVFYETQIDNAAKRENTQPCFPCSGSGAQR

Query:  CRFCMGTGNVTVELGGDDKEVSRCINCDGVGTLTCTTCQGSGIQPRYLDRREFKDDD
        CRFCMGTGNVTVELGGDDKEVSRCINCDGVGTLTCTTCQGSGIQPRYLDRREFKDDD
Subjt:  CRFCMGTGNVTVELGGDDKEVSRCINCDGVGTLTCTTCQGSGIQPRYLDRREFKDDD

XP_008466492.1 PREDICTED: protein SPA, chloroplastic [Cucumis melo]

1.7e-84

98.09

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Query:  MTVAPSLSRLHSPFLYCPLKPTPSTSLSVTFSGNQRSPPSYPRIRAIDLDQNTVVALSVGLVSVAIGIGIPVFYETQIDNAAKRENTQPCFPCSGSGAQR
        MTVAPSLSRLHSPFLYCPLKPT STSLSVTFSGNQRSPPSYPRIRAIDLDQNTVVALSVGLVSVA+GIGIPVFYETQIDNAAKRENTQPCFPCSGSGAQR
Subjt:  MTVAPSLSRLHSPFLYCPLKPTPSTSLSVTFSGNQRSPPSYPRIRAIDLDQNTVVALSVGLVSVAIGIGIPVFYETQIDNAAKRENTQPCFPCSGSGAQR

Query:  CRFCMGTGNVTVELGGDDKEVSRCINCDGVGTLTCTTCQGSGIQPRYLDRREFKDDD
        CRFCMGTGNVTVELGGD+KEVSRCINCDGVGTLTCTTCQGSGIQPRYLDRREFKDDD
Subjt:  CRFCMGTGNVTVELGGDDKEVSRCINCDGVGTLTCTTCQGSGIQPRYLDRREFKDDD

XP_022142253.1 protein SPA, chloroplastic [Momordica charantia]

6.1e-79

92.36

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Query:  MTVAPSLSRLHSPFLYCPLKPTPSTSLSVTFSGNQRSPPSYPRIRAIDLDQNTVVALSVGLVSVAIGIGIPVFYETQIDNAAKRENTQPCFPCSGSGAQR
        MT APSLSRLHSPFLY PLKPT + SLS+TFS NQRSP SYPRIRAIDLDQNTVVALSVGLVSVA+GIGIPVFYETQIDNAAKRENTQPCFPCSGSGAQ+
Subjt:  MTVAPSLSRLHSPFLYCPLKPTPSTSLSVTFSGNQRSPPSYPRIRAIDLDQNTVVALSVGLVSVAIGIGIPVFYETQIDNAAKRENTQPCFPCSGSGAQR

Query:  CRFCMGTGNVTVELGGDDKEVSRCINCDGVGTLTCTTCQGSGIQPRYLDRREFKDDD
        CRFCMGTGNVTVELGGD+KEVSRCINC+GVGTLTCTTCQGSGIQPRYLDRREFKDDD
Subjt:  CRFCMGTGNVTVELGGDDKEVSRCINCDGVGTLTCTTCQGSGIQPRYLDRREFKDDD

XP_022936404.1 protein SPA, chloroplastic [Cucurbita moschata]

1.5e-80

93.63

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Query:  MTVAPSLSRLHSPFLYCPLKPTPSTSLSVTFSGNQRSPPSYPRIRAIDLDQNTVVALSVGLVSVAIGIGIPVFYETQIDNAAKRENTQPCFPCSGSGAQR
        MTVAPSLSRLHSPFLYCPLKPT S SLS+TFS NQRSP SYPRIRAIDLDQNTVVALSVGL S+A+GIGIPVFYETQIDNAAKRENTQPCFPC+GSGAQR
Subjt:  MTVAPSLSRLHSPFLYCPLKPTPSTSLSVTFSGNQRSPPSYPRIRAIDLDQNTVVALSVGLVSVAIGIGIPVFYETQIDNAAKRENTQPCFPCSGSGAQR

Query:  CRFCMGTGNVTVELGGDDKEVSRCINCDGVGTLTCTTCQGSGIQPRYLDRREFKDDD
        CRFCMGTGNVTVELGGD+KEVSRCINCDGVGTLTCTTCQGSGIQPRYLDRREFKDDD
Subjt:  CRFCMGTGNVTVELGGDDKEVSRCINCDGVGTLTCTTCQGSGIQPRYLDRREFKDDD

XP_038899789.1 protein SPA, chloroplastic [Benincasa hispida]

1.7e-81

94.9

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Query:  MTVAPSLSRLHSPFLYCPLKPTPSTSLSVTFSGNQRSPPSYPRIRAIDLDQNTVVALSVGLVSVAIGIGIPVFYETQIDNAAKRENTQPCFPCSGSGAQR
        MTVAPS+SRLHSPFLYCPLKPT STSLSVTFS NQRSP +YPRIRAIDLDQNTVVALSVGLVSVA+GIGIPVFYETQIDNAAKRENTQPCFPCSGSGAQR
Subjt:  MTVAPSLSRLHSPFLYCPLKPTPSTSLSVTFSGNQRSPPSYPRIRAIDLDQNTVVALSVGLVSVAIGIGIPVFYETQIDNAAKRENTQPCFPCSGSGAQR

Query:  CRFCMGTGNVTVELGGDDKEVSRCINCDGVGTLTCTTCQGSGIQPRYLDRREFKDDD
        CRFCMGTGNVTVELGGD+KEVSRCINCDG GTLTCTTCQGSGIQPRYLDRREFKDDD
Subjt:  CRFCMGTGNVTVELGGDDKEVSRCINCDGVGTLTCTTCQGSGIQPRYLDRREFKDDD

TrEMBL top hits

e value

%identity

Alignment

A0A0A0LJ55 Uncharacterized protein

2.5e-86

100

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Query:  MTVAPSLSRLHSPFLYCPLKPTPSTSLSVTFSGNQRSPPSYPRIRAIDLDQNTVVALSVGLVSVAIGIGIPVFYETQIDNAAKRENTQPCFPCSGSGAQR
        MTVAPSLSRLHSPFLYCPLKPTPSTSLSVTFSGNQRSPPSYPRIRAIDLDQNTVVALSVGLVSVAIGIGIPVFYETQIDNAAKRENTQPCFPCSGSGAQR
Subjt:  MTVAPSLSRLHSPFLYCPLKPTPSTSLSVTFSGNQRSPPSYPRIRAIDLDQNTVVALSVGLVSVAIGIGIPVFYETQIDNAAKRENTQPCFPCSGSGAQR

Query:  CRFCMGTGNVTVELGGDDKEVSRCINCDGVGTLTCTTCQGSGIQPRYLDRREFKDDD
        CRFCMGTGNVTVELGGDDKEVSRCINCDGVGTLTCTTCQGSGIQPRYLDRREFKDDD
Subjt:  CRFCMGTGNVTVELGGDDKEVSRCINCDGVGTLTCTTCQGSGIQPRYLDRREFKDDD

A0A1S3CRE4 protein SPA, chloroplastic

8.1e-85

98.09

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Query:  MTVAPSLSRLHSPFLYCPLKPTPSTSLSVTFSGNQRSPPSYPRIRAIDLDQNTVVALSVGLVSVAIGIGIPVFYETQIDNAAKRENTQPCFPCSGSGAQR
        MTVAPSLSRLHSPFLYCPLKPT STSLSVTFSGNQRSPPSYPRIRAIDLDQNTVVALSVGLVSVA+GIGIPVFYETQIDNAAKRENTQPCFPCSGSGAQR
Subjt:  MTVAPSLSRLHSPFLYCPLKPTPSTSLSVTFSGNQRSPPSYPRIRAIDLDQNTVVALSVGLVSVAIGIGIPVFYETQIDNAAKRENTQPCFPCSGSGAQR

Query:  CRFCMGTGNVTVELGGDDKEVSRCINCDGVGTLTCTTCQGSGIQPRYLDRREFKDDD
        CRFCMGTGNVTVELGGD+KEVSRCINCDGVGTLTCTTCQGSGIQPRYLDRREFKDDD
Subjt:  CRFCMGTGNVTVELGGDDKEVSRCINCDGVGTLTCTTCQGSGIQPRYLDRREFKDDD

A0A6J1CMU6 protein SPA, chloroplastic

3.0e-79

92.36

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Query:  MTVAPSLSRLHSPFLYCPLKPTPSTSLSVTFSGNQRSPPSYPRIRAIDLDQNTVVALSVGLVSVAIGIGIPVFYETQIDNAAKRENTQPCFPCSGSGAQR
        MT APSLSRLHSPFLY PLKPT + SLS+TFS NQRSP SYPRIRAIDLDQNTVVALSVGLVSVA+GIGIPVFYETQIDNAAKRENTQPCFPCSGSGAQ+
Subjt:  MTVAPSLSRLHSPFLYCPLKPTPSTSLSVTFSGNQRSPPSYPRIRAIDLDQNTVVALSVGLVSVAIGIGIPVFYETQIDNAAKRENTQPCFPCSGSGAQR

Query:  CRFCMGTGNVTVELGGDDKEVSRCINCDGVGTLTCTTCQGSGIQPRYLDRREFKDDD
        CRFCMGTGNVTVELGGD+KEVSRCINC+GVGTLTCTTCQGSGIQPRYLDRREFKDDD
Subjt:  CRFCMGTGNVTVELGGDDKEVSRCINCDGVGTLTCTTCQGSGIQPRYLDRREFKDDD

A0A6J1F877 protein SPA, chloroplastic

7.1e-81

93.63

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Query:  MTVAPSLSRLHSPFLYCPLKPTPSTSLSVTFSGNQRSPPSYPRIRAIDLDQNTVVALSVGLVSVAIGIGIPVFYETQIDNAAKRENTQPCFPCSGSGAQR
        MTVAPSLSRLHSPFLYCPLKPT S SLS+TFS NQRSP SYPRIRAIDLDQNTVVALSVGL S+A+GIGIPVFYETQIDNAAKRENTQPCFPC+GSGAQR
Subjt:  MTVAPSLSRLHSPFLYCPLKPTPSTSLSVTFSGNQRSPPSYPRIRAIDLDQNTVVALSVGLVSVAIGIGIPVFYETQIDNAAKRENTQPCFPCSGSGAQR

Query:  CRFCMGTGNVTVELGGDDKEVSRCINCDGVGTLTCTTCQGSGIQPRYLDRREFKDDD
        CRFCMGTGNVTVELGGD+KEVSRCINCDGVGTLTCTTCQGSGIQPRYLDRREFKDDD
Subjt:  CRFCMGTGNVTVELGGDDKEVSRCINCDGVGTLTCTTCQGSGIQPRYLDRREFKDDD

A0A6J1IFD3 protein SPA, chloroplastic

7.1e-81

93.63

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Query:  MTVAPSLSRLHSPFLYCPLKPTPSTSLSVTFSGNQRSPPSYPRIRAIDLDQNTVVALSVGLVSVAIGIGIPVFYETQIDNAAKRENTQPCFPCSGSGAQR
        MTVAPSLSRLHSPFLYCPLKPT S SLS+TFS NQRSP SYPRIRAIDLDQNTVVALSVGL S+A+GIGIPVFYETQIDNAAKRENTQPCFPC+GSGAQR
Subjt:  MTVAPSLSRLHSPFLYCPLKPTPSTSLSVTFSGNQRSPPSYPRIRAIDLDQNTVVALSVGLVSVAIGIGIPVFYETQIDNAAKRENTQPCFPCSGSGAQR

Query:  CRFCMGTGNVTVELGGDDKEVSRCINCDGVGTLTCTTCQGSGIQPRYLDRREFKDDD
        CRFCMGTGNVTVELGGD+KEVSRCINCDGVGTLTCTTCQGSGIQPRYLDRREFKDDD
Subjt:  CRFCMGTGNVTVELGGDDKEVSRCINCDGVGTLTCTTCQGSGIQPRYLDRREFKDDD

SwissProt top hits

e value

%identity

Alignment

K4BVL1 Protein SPA, chloroplastic

1.3e-63

74.84

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Query:  MTVAPSLSRLHSPFLYCPLK-PTPSTS-LSVTFSGNQRSPPSYPRIRAIDLDQNTVVALSVGLVSVAIGIGIPVFYETQIDNAAKRENTQPCFPCSGSGA
        M  APSLSR  SPF+  PLK PT S+S  +  F    R   SYP I+A+DLDQNTV+A++VG++SVAIG+GIPVFYETQIDNAAKRENTQPCFPC+G+GA
Subjt:  MTVAPSLSRLHSPFLYCPLK-PTPSTS-LSVTFSGNQRSPPSYPRIRAIDLDQNTVVALSVGLVSVAIGIGIPVFYETQIDNAAKRENTQPCFPCSGSGA

Query:  QRCRFCMGTGNVTVELGGDDKEVSRCINCDGVGTLTCTTCQGSGIQPRYLDRREFKDDD
        Q+CRFCMGTG+VTVELGG + EVSRCINCDG G LTCTTCQGSGIQPRYLDRREFKDDD
Subjt:  QRCRFCMGTGNVTVELGGDDKEVSRCINCDGVGTLTCTTCQGSGIQPRYLDRREFKDDD

Q8GSJ6 Protein disulfide-isomerase LQY1, chloroplastic

8.4e-63

75.64

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Query:  APSLSRLHSPFLYCPLKPTPSTSLSVTFSG-NQRSP-PSYPRIRAIDLDQNTVVALSVGLVSVAIGIGIPVFYETQIDNAAKRENTQPCFPCSGSGAQRC
        APS  RLHSPF++CP+  TPS     +FS  N RSP  SYPRI+A +LD NTVVA+SVG+ SVA+GIGIPVFYETQIDNAAKRENTQPCFPC+G+GAQ+C
Subjt:  APSLSRLHSPFLYCPLKPTPSTSLSVTFSG-NQRSP-PSYPRIRAIDLDQNTVVALSVGLVSVAIGIGIPVFYETQIDNAAKRENTQPCFPCSGSGAQRC

Query:  RFCMGTGNVTVELGGDDKEVSRCINCDGVGTLTCTTCQGSGIQPRYLDRREFKDDD
        R C+G+GNVTVELGG +KEVS CINCDG G+LTCTTCQGSG+QPRYLDRREFKDDD
Subjt:  RFCMGTGNVTVELGGDDKEVSRCINCDGVGTLTCTTCQGSGIQPRYLDRREFKDDD

Arabidopsis top hits

e value

%identity

Alignment

AT1G75690.1 DnaJ/Hsp40 cysteine-rich domain superfamily protein

6.0e-64

75.64

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Query:  APSLSRLHSPFLYCPLKPTPSTSLSVTFSG-NQRSP-PSYPRIRAIDLDQNTVVALSVGLVSVAIGIGIPVFYETQIDNAAKRENTQPCFPCSGSGAQRC
        APS  RLHSPF++CP+  TPS     +FS  N RSP  SYPRI+A +LD NTVVA+SVG+ SVA+GIGIPVFYETQIDNAAKRENTQPCFPC+G+GAQ+C
Subjt:  APSLSRLHSPFLYCPLKPTPSTSLSVTFSG-NQRSP-PSYPRIRAIDLDQNTVVALSVGLVSVAIGIGIPVFYETQIDNAAKRENTQPCFPCSGSGAQRC

Query:  RFCMGTGNVTVELGGDDKEVSRCINCDGVGTLTCTTCQGSGIQPRYLDRREFKDDD
        R C+G+GNVTVELGG +KEVS CINCDG G+LTCTTCQGSG+QPRYLDRREFKDDD
Subjt:  RFCMGTGNVTVELGGDDKEVSRCINCDGVGTLTCTTCQGSGIQPRYLDRREFKDDD

AT4G13670.1 plastid transcriptionally active 5

9.0e-04

30.48

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Query:  RAIDLDQNTVVALSVGL---VSVAIGIGIPVFYETQIDNAAKRENTQPCFPCSGSGAQRCRFCMGTGNVTVE------LGGDDKEVSRCINCDGVGTLTC
        R +D+ QN V  L        S  IG   PV      D +        C  C G G   C  C GTG   +E      +G D K    C  C+G+G   C
Subjt:  RAIDLDQNTVVALSVGL---VSVAIGIGIPVFYETQIDNAAKRENTQPCFPCSGSGAQRCRFCMGTGNVTVE------LGGDDKEVSRCINCDGVGTLTC

Query:  TTCQG
          C G
Subjt:  TTCQG

Sequences

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CDS sequence

Show/hide CDS sequence

ATGACAGTAGCACCTTCGCTTTCCCGCCTCCATTCTCCATTTCTGTATTGTCCTCTCAAGCCAACTCCATCTACCTCTTTATCAGTCACATTCTCTGGAAATCAACGATC
GCCACCATCATATCCACGCATCAGAGCAATAGATCTTGACCAAAACACGGTGGTGGCACTTTCAGTTGGGCTGGTGAGTGTTGCAATTGGAATAGGTATTCCCGTCTTCT
ACGAAACCCAAATTGATAATGCTGCAAAGCGTGAAAATACTCAGCCCTGCTTTCCCTGCAGTGGTTCAGGAGCACAGAGATGCAGATTTTGCATGGGAACTGGCAATGTG
ACCGTAGAACTTGGTGGAGATGACAAAGAAGTCTCCCGGTGTATTAACTGTGATGGTGTTGGCACATTGACATGTACTACATGTCAGGGCTCTGGAATTCAACCTCGATA
CCTAGATCGCAGAGAATTTAAAGATGATGATTGA

mRNA sequence

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TGGGTCTGTAGTAGAGCAGAGGCAGCCAGTAACGGATATCCAAAATCCTGGAATGCGTGGTGAAGCTTTGTAGCTTTGAAACAAACCACAGCCTCAAGTGTTTTCTTTAG
GAATTAGGACTGAGACTGACTTTCTTTTTCTTTCTGATTCGGAGCTCTCAGAAGCAAAGGAATTGAGTCCAAGGAATTCAGAAATGACAGTAGCACCTTCGCTTTCCCGC
CTCCATTCTCCATTTCTGTATTGTCCTCTCAAGCCAACTCCATCTACCTCTTTATCAGTCACATTCTCTGGAAATCAACGATCGCCACCATCATATCCACGCATCAGAGC
AATAGATCTTGACCAAAACACGGTGGTGGCACTTTCAGTTGGGCTGGTGAGTGTTGCAATTGGAATAGGTATTCCCGTCTTCTACGAAACCCAAATTGATAATGCTGCAA
AGCGTGAAAATACTCAGCCCTGCTTTCCCTGCAGTGGTTCAGGAGCACAGAGATGCAGATTTTGCATGGGAACTGGCAATGTGACCGTAGAACTTGGTGGAGATGACAAA
GAAGTCTCCCGGTGTATTAACTGTGATGGTGTTGGCACATTGACATGTACTACATGTCAGGGCTCTGGAATTCAACCTCGATACCTAGATCGCAGAGAATTTAAAGATGA
TGATTGAACCCCTGCAGAACCAAACCCGGCAACATCACCAATTCCGATTTTGTGTTTAATTTGATGGCTTGAACCTTGTTAGTTCCATCGAATTGAAGAGCTGGGTAACT
TCTACCTAGCACTTCTTTTCGGTAACATGCATTCTTCTAATGTATATCTGTGGTTAATAATACAAACATTGTAAAAGGAGAGAAGAATTAACTGTACTATCCCAAGATTA
TGAATTCATCTCTATTCACTGTCAGTGAAATCAGAAATGGGGGATCAAACGCAATCTGATAATCACAAGCACTTCTTTTTGGTACTTTTTCCGTGCATTCTTCTAAAGTA
TAAGAATATCTGTGGCTAATAGAGGAGAGAAGAATTTAGGTGTACTAAGCCAAGATTATGAATTCATCTGTATTCACTGTCAGTAAAATGGGGGGATCAAACTCTATCTG
ATATCACTACCTAGTAATAGTAGCCGGTGCAGGTGGATCTCATCTTTTAGGCACAAGCAGAGAACAGCTGAATTACCAGATCATACATGGTTAAAAATTTTGCAACCATA
TCAGGAATTTGAAACTGGAAGGGTCACTATGAAAAATCCATATAATTAATCGTGAAGTCCGTGAATTCAGATGCTAGCCAAACATGCAGAGGCAGCTAAATCACAGGCAA
GGAGGAGATCATTCCCGTAATGAGCCTATCAAATAATCGGCAACATTTGTTATAAGACATTTCAAGTAGACGAATTTCAAGGCACTGCAATGGGCATCTAAAAAAACAAT
GAATTTGGAAGCATATTTCCCGGGTAACCATGCCGGTGACAGAACCATGAAGAATCCTAATGCGCTGCTACCAAAACAATGCATGCTTGATTCTGAGCAAAAACCAGTTC
ATTGGAGTTAGCAGAGGCAAATAAGCGTATATTTACACTTTGAATATCGCAGCACCAGCACAAAAGCCATCCAGGTTAACATGAGGTAGCTTTACATTTACGACAGTTTT
CTTCTAACCACCTCAAACGTATCTTGTTCCGTTTAAGTAAAATAAAAGTCTCCCTAAAATTTGGGGTATCAAAGAGATCCAAAGCAACAAAATACAGCCGGTTATCATTG
CTTTCAATCTCACCCAGGGCACCTATGCAATTAGTTATACTGAGTCTAGGTCTTCGATCAGTAGGCATTCTTCAGCTGTTCTTGAAAGATTCTACTTCTAACAAGTCTAA
CAATGCTTATGCCATTATCAGATGGGTTTCTGTCATGCTTTGACCTATGGAAGTATGTGCACCTAACTGTCGCTTTTTCTTGCTCTACCACGGCCTTCGTCATTTTTCCA
GAAAATAACTAATTTCCATGCTTAGTTTTGGTTAGGGTTTTCAGGAGACATGGTTCCACGTCCACCCATCAGGACATGAATTTATGACTAATCTATTTGTTCCAGCAGAT
CTATCCAGCTATTCTTAGTGGCTGGATTGTGCATACTTCTTACCAGCAGCTGATTCGGTGAACATTGTGCACAACTGCTCATATATGATGGGACAACAATCTTCGAATTT
GAGTATCTCAAACCGATTCTGGACCTATGAAAAGAATCTACCAGAAAATTAAGGTAGACCTGTAAGGCAAAACTAGGTAAGCTTACGAAGGAAAGCAATGTAGCCCAAGA
TCCTCCCCCTAATCAAACCCAGTGCTACAAGAATCATCAATTGTGAGGTCAATTGTTATTGGAAGTTGATATCAGTTCGCTTATTGAGTTCATCACGAATGTGAATTCAT
GTTTTCTTGTCAAGCACGTTGTTTTGTCTCTCTGTTGAATGTGCGTGTAAACATTGTAAAGTATATCACCAAAGTATAATATAAATCAACAGATTCGGAAGG

Protein sequence

Show/hide protein sequence

MTVAPSLSRLHSPFLYCPLKPTPSTSLSVTFSGNQRSPPSYPRIRAIDLDQNTVVALSVGLVSVAIGIGIPVFYETQIDNAAKRENTQPCFPCSGSGAQRCRFCMGTGNV
TVELGGDDKEVSRCINCDGVGTLTCTTCQGSGIQPRYLDRREFKDDD

CSPI03G43330 (gene) of Cucumber (PI 183967) v1 genome