CuGenDBv2

Gene ID	Carg08501
Organism	Cucurbita argyrosperma subsp. argyrosperma cv. SMH-JMG-627 (Silver-seed gourd (SMH-JMG-627) v2)
Description	ceramide kinase isoform X2
Genome location	Carg_Chr02:5345008..5351185
RNA-Seq Expression	Carg08501
Synteny	Carg08501
Gene Ontology terms	GO:0006672 - ceramide metabolic process (biological process) GO:0043067 - regulation of programmed cell death (biological process) GO:0046834 - lipid phosphorylation (biological process) GO:0001729 - ceramide kinase activity (molecular function) GO:0003951 - NAD+ kinase activity (molecular function) GO:0005509 - calcium ion binding (molecular function)
InterPro domains	IPR016064 - NAD kinase/diacylglycerol kinase-like domain superfamily

Homology

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GenBank top hits

e value

%identity

Alignment

KAG7035546.1 Ceramide kinase [Cucurbita argyrosperma subsp. argyrosperma]

6.1e-66

100

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Query:  MGPRRYDYAGTRVFLRHSSYEAEVAYVDIKSEDTNTNGKRVLCCHNCSICSTKVYLQHSNTGSDSSQDETRWLKSKGRFLSIGAAVISCRNEKASDGLVA
        MGPRRYDYAGTRVFLRHSSYEAEVAYVDIKSEDTNTNGKRVLCCHNCSICSTKVYLQHSNTGSDSSQDETRWLKSKGRFLSIGAAVISCRNEKASDGLVA
Subjt:  MGPRRYDYAGTRVFLRHSSYEAEVAYVDIKSEDTNTNGKRVLCCHNCSICSTKVYLQHSNTGSDSSQDETRWLKSKGRFLSIGAAVISCRNEKASDGLVA

Query:  DAHLSDGFLHLILIRDCHHALYLW
        DAHLSDGFLHLILIRDCHHALYLW
Subjt:  DAHLSDGFLHLILIRDCHHALYLW

XP_022957891.1 ceramide kinase isoform X1 [Cucurbita moschata]

2.3e-65

99.19

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Query:  MGPRRYDYAGTRVFLRHSSYEAEVAYVDIKSEDTNTNGKRVLCCHNCSICSTKVYLQHSNTGSDSSQDETRWLKSKGRFLSIGAAVISCRNEKASDGLVA
        MGPRRYDYAGTRVFLRHSSYEAEVAYVDIKSEDTNTNGKRVLCCHNCSICSTKVYLQHSNTGSDSSQDETRWLKSKGRFLSIGAAVISCRNEKA DGLVA
Subjt:  MGPRRYDYAGTRVFLRHSSYEAEVAYVDIKSEDTNTNGKRVLCCHNCSICSTKVYLQHSNTGSDSSQDETRWLKSKGRFLSIGAAVISCRNEKASDGLVA

Query:  DAHLSDGFLHLILIRDCHHALYLW
        DAHLSDGFLHLILIRDCHHALYLW
Subjt:  DAHLSDGFLHLILIRDCHHALYLW

XP_022957892.1 ceramide kinase isoform X2 [Cucurbita moschata]

2.3e-65

99.19

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Query:  MGPRRYDYAGTRVFLRHSSYEAEVAYVDIKSEDTNTNGKRVLCCHNCSICSTKVYLQHSNTGSDSSQDETRWLKSKGRFLSIGAAVISCRNEKASDGLVA
        MGPRRYDYAGTRVFLRHSSYEAEVAYVDIKSEDTNTNGKRVLCCHNCSICSTKVYLQHSNTGSDSSQDETRWLKSKGRFLSIGAAVISCRNEKA DGLVA
Subjt:  MGPRRYDYAGTRVFLRHSSYEAEVAYVDIKSEDTNTNGKRVLCCHNCSICSTKVYLQHSNTGSDSSQDETRWLKSKGRFLSIGAAVISCRNEKASDGLVA

Query:  DAHLSDGFLHLILIRDCHHALYLW
        DAHLSDGFLHLILIRDCHHALYLW
Subjt:  DAHLSDGFLHLILIRDCHHALYLW

XP_023534408.1 ceramide kinase isoform X1 [Cucurbita pepo subsp. pepo]

9.8e-64

96.77

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Query:  MGPRRYDYAGTRVFLRHSSYEAEVAYVDIKSEDTNTNGKRVLCCHNCSICSTKVYLQHSNTGSDSSQDETRWLKSKGRFLSIGAAVISCRNEKASDGLVA
        MGPRRYDYAGTRVFLRHSSYEAEVAYVDIKSEDTNTNGKRVLCCHNCSICSTK YLQHSNTGSDS Q+ETRWLKSKGRFLSIGAAVISCRNEKA DGLVA
Subjt:  MGPRRYDYAGTRVFLRHSSYEAEVAYVDIKSEDTNTNGKRVLCCHNCSICSTKVYLQHSNTGSDSSQDETRWLKSKGRFLSIGAAVISCRNEKASDGLVA

Query:  DAHLSDGFLHLILIRDCHHALYLW
        DAHLSDGFLHLILIRDCHHALYLW
Subjt:  DAHLSDGFLHLILIRDCHHALYLW

XP_023534410.1 ceramide kinase isoform X2 [Cucurbita pepo subsp. pepo]

9.8e-64

96.77

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Query:  MGPRRYDYAGTRVFLRHSSYEAEVAYVDIKSEDTNTNGKRVLCCHNCSICSTKVYLQHSNTGSDSSQDETRWLKSKGRFLSIGAAVISCRNEKASDGLVA
        MGPRRYDYAGTRVFLRHSSYEAEVAYVDIKSEDTNTNGKRVLCCHNCSICSTK YLQHSNTGSDS Q+ETRWLKSKGRFLSIGAAVISCRNEKA DGLVA
Subjt:  MGPRRYDYAGTRVFLRHSSYEAEVAYVDIKSEDTNTNGKRVLCCHNCSICSTKVYLQHSNTGSDSSQDETRWLKSKGRFLSIGAAVISCRNEKASDGLVA

Query:  DAHLSDGFLHLILIRDCHHALYLW
        DAHLSDGFLHLILIRDCHHALYLW
Subjt:  DAHLSDGFLHLILIRDCHHALYLW

TrEMBL top hits

e value

%identity

Alignment

A0A1S4DS71 ceramide kinase isoform X6

3.0e-58

90.32

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Query:  MGPRRYDYAGTRVFLRHSSYEAEVAYVDIKSEDTNTNGKRVLCCHNCSICSTKVYLQHSNTGSDSSQDETRWLKSKGRFLSIGAAVISCRNEKASDGLVA
        MGPRRYDYAGTRVFLRHSSYEAEVAYVD KSEDTN NGKRVLC  NCSIC+T+ +LQHS+TGS S QDETRWLKSKGRFLSIGAAVISCRNEKA DGLVA
Subjt:  MGPRRYDYAGTRVFLRHSSYEAEVAYVDIKSEDTNTNGKRVLCCHNCSICSTKVYLQHSNTGSDSSQDETRWLKSKGRFLSIGAAVISCRNEKASDGLVA

Query:  DAHLSDGFLHLILIRDCHHALYLW
        DAHLSDGFLHLILIRDCHHALYLW
Subjt:  DAHLSDGFLHLILIRDCHHALYLW

A0A6J1H0E8 ceramide kinase isoform X2

1.1e-65

99.19

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Query:  MGPRRYDYAGTRVFLRHSSYEAEVAYVDIKSEDTNTNGKRVLCCHNCSICSTKVYLQHSNTGSDSSQDETRWLKSKGRFLSIGAAVISCRNEKASDGLVA
        MGPRRYDYAGTRVFLRHSSYEAEVAYVDIKSEDTNTNGKRVLCCHNCSICSTKVYLQHSNTGSDSSQDETRWLKSKGRFLSIGAAVISCRNEKA DGLVA
Subjt:  MGPRRYDYAGTRVFLRHSSYEAEVAYVDIKSEDTNTNGKRVLCCHNCSICSTKVYLQHSNTGSDSSQDETRWLKSKGRFLSIGAAVISCRNEKASDGLVA

Query:  DAHLSDGFLHLILIRDCHHALYLW
        DAHLSDGFLHLILIRDCHHALYLW
Subjt:  DAHLSDGFLHLILIRDCHHALYLW

A0A6J1H0H1 ceramide kinase isoform X1

1.1e-65

99.19

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Query:  MGPRRYDYAGTRVFLRHSSYEAEVAYVDIKSEDTNTNGKRVLCCHNCSICSTKVYLQHSNTGSDSSQDETRWLKSKGRFLSIGAAVISCRNEKASDGLVA
        MGPRRYDYAGTRVFLRHSSYEAEVAYVDIKSEDTNTNGKRVLCCHNCSICSTKVYLQHSNTGSDSSQDETRWLKSKGRFLSIGAAVISCRNEKA DGLVA
Subjt:  MGPRRYDYAGTRVFLRHSSYEAEVAYVDIKSEDTNTNGKRVLCCHNCSICSTKVYLQHSNTGSDSSQDETRWLKSKGRFLSIGAAVISCRNEKASDGLVA

Query:  DAHLSDGFLHLILIRDCHHALYLW
        DAHLSDGFLHLILIRDCHHALYLW
Subjt:  DAHLSDGFLHLILIRDCHHALYLW

A0A6J1JXG6 ceramide kinase isoform X2

6.2e-64

95.97

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Query:  MGPRRYDYAGTRVFLRHSSYEAEVAYVDIKSEDTNTNGKRVLCCHNCSICSTKVYLQHSNTGSDSSQDETRWLKSKGRFLSIGAAVISCRNEKASDGLVA
        MGPRRYDYAGTRVFLRHSSYEAE+AYVDIKSEDT+TNGKRVLCCHNCSICSTK YLQHSNTGSDS QDETRWLKSKGRFLSIGAAVISCRNEKA DGLVA
Subjt:  MGPRRYDYAGTRVFLRHSSYEAEVAYVDIKSEDTNTNGKRVLCCHNCSICSTKVYLQHSNTGSDSSQDETRWLKSKGRFLSIGAAVISCRNEKASDGLVA

Query:  DAHLSDGFLHLILIRDCHHALYLW
        DAHLSDGFLHLILIRDCHHALYLW
Subjt:  DAHLSDGFLHLILIRDCHHALYLW

A0A6J1K0R2 ceramide kinase isoform X1

6.2e-64

95.97

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Query:  MGPRRYDYAGTRVFLRHSSYEAEVAYVDIKSEDTNTNGKRVLCCHNCSICSTKVYLQHSNTGSDSSQDETRWLKSKGRFLSIGAAVISCRNEKASDGLVA
        MGPRRYDYAGTRVFLRHSSYEAE+AYVDIKSEDT+TNGKRVLCCHNCSICSTK YLQHSNTGSDS QDETRWLKSKGRFLSIGAAVISCRNEKA DGLVA
Subjt:  MGPRRYDYAGTRVFLRHSSYEAEVAYVDIKSEDTNTNGKRVLCCHNCSICSTKVYLQHSNTGSDSSQDETRWLKSKGRFLSIGAAVISCRNEKASDGLVA

Query:  DAHLSDGFLHLILIRDCHHALYLW
        DAHLSDGFLHLILIRDCHHALYLW
Subjt:  DAHLSDGFLHLILIRDCHHALYLW

SwissProt top hits

e value

%identity

Alignment

C0LT23 Ceramide kinase

3.0e-31

51.7

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Query:  MGPRRYDYAGTRVFLRHSSYEAEVAYVD-------IKSEDTNTNG-----------KRVLCCHNCSIC-STKVYLQHS-NTGSDSSQ---DETRWLKSKG
        MGP RYD++GT VFL+H SYEA+VA+++         S + N NG           ++ +C  NC IC  T    Q+S +   DSS+   +  +W+ SKG
Subjt:  MGPRRYDYAGTRVFLRHSSYEAEVAYVD-------IKSEDTNTNG-----------KRVLCCHNCSIC-STKVYLQHS-NTGSDSSQ---DETRWLKSKG

Query:  RFLSIGAAVISCRNEKASDGLVADAHLSDGFLHLILIRDCHHALYLW
        RFLS+GAAVISCRNE+A DGLVADAHLSDGFLHL+LIRDC    YLW
Subjt:  RFLSIGAAVISCRNEKASDGLVADAHLSDGFLHLILIRDCHHALYLW

Q6USK2 Ceramide kinase

4.4e-35

51.8

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Query:  MGPRRYDYAGTRVFLRHSSYEAEVAYVDIKSEDT---------------NTNGKRVLCCHNCSICSTKVYLQHSNTGSDSSQDETRWLKSKGRFLSIGAA
        MGP+RYDY GT++FL+H SYEAEV + + +SE++                T  +++LC  NC IC++KV    ++T  +   ++TRW ++KGRFLSIGAA
Subjt:  MGPRRYDYAGTRVFLRHSSYEAEVAYVDIKSEDT---------------NTNGKRVLCCHNCSICSTKVYLQHSNTGSDSSQDETRWLKSKGRFLSIGAA

Query:  VISCRNEKASDGLVADAHLSDGFLHLILIRDCHHALYLW
        V+S RNE+A DGLV DAHLSDGFLHLILI+DC    YLW
Subjt:  VISCRNEKASDGLVADAHLSDGFLHLILIRDCHHALYLW

Q8K4Q7 Ceramide kinase

3.2e-09

30.47

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Query:  MGPRRYDYAGTRVFLRHSSYEAEVAYVDIKSEDTNTNGKRVLCCHNCSIC-STKVYLQHSNT----GSDSSQDETRWLKSKGRFLSIGAAVISCRNEKAS
        MG  RYD++G + FL H  YE  ++++  +    +    +  C   C +C  +K  L+        G +++++   W  + G+FL+I A  +SC   ++ 
Subjt:  MGPRRYDYAGTRVFLRHSSYEAEVAYVDIKSEDTNTNGKRVLCCHNCSIC-STKVYLQHSNT----GSDSSQDETRWLKSKGRFLSIGAAVISCRNEKAS

Query:  DGLVADAHLSDGFLHLILIRDCHHALYL
         GL   AHL DG   LILIR C    +L
Subjt:  DGLVADAHLSDGFLHLILIRDCHHALYL

Q8TCT0 Ceramide kinase

3.8e-10

32.03

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Query:  MGPRRYDYAGTRVFLRHSSYEAEVAYVDIKSEDTNTNGKRVLCCHNCSIC-STKVYLQHSNT----GSDSSQDETRWLKSKGRFLSIGAAVISCRNEKAS
        +G  RYD++G + FL H  YE  V+++  +     +   R  C   C +C  +K  L+        G ++++D   W    G+FL+I A  +SC   ++ 
Subjt:  MGPRRYDYAGTRVFLRHSSYEAEVAYVDIKSEDTNTNGKRVLCCHNCSIC-STKVYLQHSNT----GSDSSQDETRWLKSKGRFLSIGAAVISCRNEKAS

Query:  DGLVADAHLSDGFLHLILIRDCHHALYL
         GL   AHL DG   LILIR C    +L
Subjt:  DGLVADAHLSDGFLHLILIRDCHHALYL

Arabidopsis top hits

e value

%identity

Alignment

AT5G51290.1 Diacylglycerol kinase family protein

3.2e-36

51.8

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Query:  MGPRRYDYAGTRVFLRHSSYEAEVAYVDIKSEDT---------------NTNGKRVLCCHNCSICSTKVYLQHSNTGSDSSQDETRWLKSKGRFLSIGAA
        MGP+RYDY GT++FL+H SYEAEV + + +SE++                T  +++LC  NC IC++KV    ++T  +   ++TRW ++KGRFLSIGAA
Subjt:  MGPRRYDYAGTRVFLRHSSYEAEVAYVDIKSEDT---------------NTNGKRVLCCHNCSICSTKVYLQHSNTGSDSSQDETRWLKSKGRFLSIGAA

Query:  VISCRNEKASDGLVADAHLSDGFLHLILIRDCHHALYLW
        V+S RNE+A DGLV DAHLSDGFLHLILI+DC    YLW
Subjt:  VISCRNEKASDGLVADAHLSDGFLHLILIRDCHHALYLW

Sequences

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CDS sequence

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ATGGGGCCTCGACGTTACGATTATGCTGGTACAAGAGTGTTCTTGAGGCACAGTTCATACGAGGCCGAGGTAGCCTACGTAGATATAAAGTCGGAGGATACGAATACAAA
TGGGAAAAGAGTGCTCTGTTGTCATAACTGCAGTATTTGTAGCACAAAGGTATACTTACAGCATTCTAACACTGGCTCGGATTCGAGTCAGGACGAAACAAGATGGTTGA
AATCGAAGGGACGTTTCCTAAGCATTGGCGCTGCGGTAATCTCATGTCGTAATGAAAAAGCATCAGATGGCTTGGTGGCTGATGCTCACCTTTCGGATGGCTTCTTGCAT
CTTATATTGATCAGAGACTGCCACCATGCTCTCTATCTTTGGTAA

mRNA sequence

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AGTTTCTTCTTGATTTCAAGACCCATTGACATCCCCTGATTCTCAGCTGAAACATCGTCCGCTTAATGACTTGCTTACTAAAATGGATATTCAATTAACCACCGCCCAAA
TCGTGGGTTTCAGAATCAGCGCCATTTGAAGTTCATTGCGATTCTTGAATGGAGCGGGAACAAAGCTGCTCCGCCGCCGTGAAAGATGAATTTCATCCAAATCCACACAT
CGATGCCCAAACGTTGATTTTGAAATCGATTTTCTTCTTGGATGGCGTCGGCGAGGTCATCGTCACTTGCAATTCAGATGGGTTGTTTTGGGAATTGGTTGACTTCCCAG
AATCTGTTGGCTCAGGATGCATGGGCATTAAGCTTGTTCCCGATGTTGCAGCAGAGGTCAAGTTTTCTGATGCTTATGCTGTTGAGTTTGACGACTTTGGAGTGATTCAT
AAATCAAAACTTGCGGCTGTTGCAAGCTGTATGATATGCAATGAATACGAGAAACAGATGTATAGATTTACAGTGCACAGTTTTCAAAGATCAAAATCTCAGCCTGCTCA
TTGGGCCCTGACTATGTTTACATTTGGACACGAGGACCAGCAAACATGTCAGATGTGGGTAAATCAGATTAATGCATCTTTGGACCTTGAAGTTGAGAGACCAAAGAATC
TTCTTGTTTTTGTTAATCCTAAGAGTGGGAAAGGGATAGGGAGCCGAACGTGGGAAGCAGTAGCTCCTATATTTTTACGTGCTGAAATAAACACGAAGGTGATTGTGACT
GAAAGAGCAGGTCATGCATTTGATGTAATGGCATCTATTGCAAACGAGGATCTAAAAATGTATGATGGTATTGTTGCTGTTGGTGGAGATGGTTTCTTCAATGAGATCCT
TAATGGGTTTCTTTTGTCGAGGCATTTGGCACATTACCCACCAGCCCCGTCGGATATTGTAGACGTCGTGCAGGCTGAAGGTAACTATTCCAGTGAAGCAATAACCGAAG
ATGTCGATCGAAGTGAAGATCAGTCGCCACTTCTCTTAAGTGCTAAATATGGTGGATCAGGACTCTCAACTTCTCAGAACTCAACAGTGTATGGTTTTGATTCAGCATTT
GATAGATGGTTCAGATTCGGAATCATTCCTGCTGGCTCAACGGACGCTATTGTGATGTGTTCTACTGGATATCGAGATCCTATTACATCAACCCTGCAAATTGTCCTGGG
TAAAAGAGTTCACCTTGATATAGCTCAAGTAGTTAGGTGGAAAGAGACTCCGACGTCAAAGTTAGAACCTCTCGTACGCTATGCGGCTTCTTTTGCTGGGTAGTTTCTCA
TCGTCGTTTGTGTCCTACTTCAAGTAGGATGATAATTAAGCTTGGGAAGTTAATTGCAATCATAATGTTGTTGACATACTTAGTAAAACCTTGGGAAGCTTCCCTCTGAA
TTTCTGTATATTTTGTTTTCAGATATGGGTTTTATGGAGATGTCATTACAGAGAGCGAAAAATTCCGCTGGATGGGGCCTCGACGTTACGATTATGCTGGTACAAGAGTG
TTCTTGAGGCACAGTTCATACGAGGCCGAGGTAGCCTACGTAGATATAAAGTCGGAGGATACGAATACAAATGGGAAAAGAGTGCTCTGTTGTCATAACTGCAGTATTTG
TAGCACAAAGGTATACTTACAGCATTCTAACACTGGCTCGGATTCGAGTCAGGACGAAACAAGATGGTTGAAATCGAAGGGACGTTTCCTAAGCATTGGCGCTGCGGTAA
TCTCATGTCGTAATGAAAAAGCATCAGATGGCTTGGTGGCTGATGCTCACCTTTCGGATGGCTTCTTGCATCTTATATTGATCAGAGACTGCCACCATGCTCTCTATCTT
TGGTAATACAATCTCCTCCATCGCGTATGGATTAAGCTTTTGTTTTTTTGCTGTTCTTATCAGCATCCCTTGGATTTGTCAAGTTCTTTGTTACTGCTTTTTGTCTGGAC
ATTTTGTCATTATGTTGTAAGGCTTTGGTTTTGTTGTTCATGGCTGTGAACAGGCATCTTACCCAGCTAGCCAAAAAAGGTGGAAATCCAATGGATTTCAAGTTTGTGGA
ACATCACAAGGTATGTTTACTGCAGCTGTCCTTTTTTGTTTCACAGTCTACGGAGTTGTAAGCCCACCGCGAACCGATATTGATCTCTTTGGACTTTCTCTCAAG

Protein sequence

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MGPRRYDYAGTRVFLRHSSYEAEVAYVDIKSEDTNTNGKRVLCCHNCSICSTKVYLQHSNTGSDSSQDETRWLKSKGRFLSIGAAVISCRNEKASDGLVADAHLSDGFLH
LILIRDCHHALYLW

Carg08501 (gene) of Silver-seed gourd (SMH-JMG-627) v2 genome