CuGenDBv2

Gene ID	Carg09053
Organism	Cucurbita argyrosperma subsp. argyrosperma cv. SMH-JMG-627 (Silver-seed gourd (SMH-JMG-627) v2)
Description	macrophage migration inhibitory factor homolog
Genome location	Carg_Chr11:1826613..1827306
RNA-Seq Expression	Carg09053
Synteny	Carg09053
Gene Ontology terms	GO:0005615 - extracellular space (cellular component) GO:0005634 - nucleus (cellular component) GO:0005737 - cytoplasm (cellular component) GO:0050178 - phenylpyruvate tautomerase activity (molecular function)
InterPro domains	IPR001398 - Macrophage migration inhibitory factor IPR014347 - Tautomerase/MIF superfamily

Homology

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GenBank top hits

e value

%identity

Alignment

KAG7021698.1 Macrophage migration inhibitory factor-like protein, partial [Cucurbita argyrosperma subsp. argyrosperma]

2.1e-58

100

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Query:  MPTLNLFTNLPVDAVVAADILKDASKAVSKILGKSESYVMILLNGSTPIVFAGTEEPAAYGELISIGGLGPSVNGKLSSTIAEIIQTKLHIDSSRFYIKF
        MPTLNLFTNLPVDAVVAADILKDASKAVSKILGKSESYVMILLNGSTPIVFAGTEEPAAYGELISIGGLGPSVNGKLSSTIAEIIQTKLHIDSSRFYIKF
Subjt:  MPTLNLFTNLPVDAVVAADILKDASKAVSKILGKSESYVMILLNGSTPIVFAGTEEPAAYGELISIGGLGPSVNGKLSSTIAEIIQTKLHIDSSRFYIKF

Query:  SDVQASFSRPSKLLSTYIKGWI
        SDVQASFSRPSKLLSTYIKGWI
Subjt:  SDVQASFSRPSKLLSTYIKGWI

XP_022925771.1 macrophage migration inhibitory factor homolog [Cucurbita moschata]

1.1e-48

99.07

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Query:  MPTLNLFTNLPVDAVVAADILKDASKAVSKILGKSESYVMILLNGSTPIVFAGTEEPAAYGELISIGGLGPSVNGKLSSTIAEIIQTKLHIDSSRFYIKF
        MPTLNLFTNLPVDAVVAADILKDASKAVSKILGKSESYVMILLNGSTPIVFAGTEEP AYGELISIGGLGPSVNGKLSSTIAEIIQTKLHIDSSRFYIKF
Subjt:  MPTLNLFTNLPVDAVVAADILKDASKAVSKILGKSESYVMILLNGSTPIVFAGTEEPAAYGELISIGGLGPSVNGKLSSTIAEIIQTKLHIDSSRFYIKF

Query:  SDVQASF
        SDVQASF
Subjt:  SDVQASF

XP_022973339.1 macrophage migration inhibitory factor homolog [Cucurbita maxima]

1.1e-48

99.07

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Query:  MPTLNLFTNLPVDAVVAADILKDASKAVSKILGKSESYVMILLNGSTPIVFAGTEEPAAYGELISIGGLGPSVNGKLSSTIAEIIQTKLHIDSSRFYIKF
        MPTLNLFTN PVDAVVAADILKDASKAVSKILGKSESYVMILLNGSTPIVFAGTEEPAAYGELISIGGLGPSVNGKLSSTIAEIIQTKLHIDSSRFYIKF
Subjt:  MPTLNLFTNLPVDAVVAADILKDASKAVSKILGKSESYVMILLNGSTPIVFAGTEEPAAYGELISIGGLGPSVNGKLSSTIAEIIQTKLHIDSSRFYIKF

Query:  SDVQASF
        SDVQASF
Subjt:  SDVQASF

XP_023529457.1 macrophage migration inhibitory factor homolog [Cucurbita pepo subsp. pepo]

1.9e-48

99.07

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Query:  MPTLNLFTNLPVDAVVAADILKDASKAVSKILGKSESYVMILLNGSTPIVFAGTEEPAAYGELISIGGLGPSVNGKLSSTIAEIIQTKLHIDSSRFYIKF
        MPTLNLFTNLPVDAVVAADILKDASKAVSKILGKSESYVMILLNGSTPIVFAGTEEPAAYGELISIGGLGPSVNGKLSSTIAEIIQTKLHIDSSRFYIKF
Subjt:  MPTLNLFTNLPVDAVVAADILKDASKAVSKILGKSESYVMILLNGSTPIVFAGTEEPAAYGELISIGGLGPSVNGKLSSTIAEIIQTKLHIDSSRFYIKF

Query:  SDVQASF
        SD QASF
Subjt:  SDVQASF

XP_038879720.1 macrophage migration inhibitory factor homolog isoform X1 [Benincasa hispida]

5.9e-45

91.59

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Query:  MPTLNLFTNLPVDAVVAADILKDASKAVSKILGKSESYVMILLNGSTPIVFAGTEEPAAYGELISIGGLGPSVNGKLSSTIAEIIQTKLHIDSSRFYIKF
        MPTLNLFTN+PVD VVAADILKDASKA+SKILGK ESYVMILLNGSTPIVFAGTEEPAAYGELISIGGLGP VNGKLSSTIAEI+QTKL IDSSRFYIKF
Subjt:  MPTLNLFTNLPVDAVVAADILKDASKAVSKILGKSESYVMILLNGSTPIVFAGTEEPAAYGELISIGGLGPSVNGKLSSTIAEIIQTKLHIDSSRFYIKF

Query:  SDVQASF
         DVQAS+
Subjt:  SDVQASF

TrEMBL top hits

e value

%identity

Alignment

A0A151SRS7 Macrophage migration inhibitory factor isogeny

4.5e-43

86.92

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Query:  MPTLNLFTNLPVDAVVAADILKDASKAVSKILGKSESYVMILLNGSTPIVFAGTEEPAAYGELISIGGLGPSVNGKLSSTIAEIIQTKLHIDSSRFYIKF
        MPTLNLFTNLPVD VVA+DIL+DA+KAV+KI+GK ESYVMILLNG  PI FAGTEEPAAYGELISIGGLGPSVNGKLSSTIAEI+QTKL+IDSSRFYIKF
Subjt:  MPTLNLFTNLPVDAVVAADILKDASKAVSKILGKSESYVMILLNGSTPIVFAGTEEPAAYGELISIGGLGPSVNGKLSSTIAEIIQTKLHIDSSRFYIKF

Query:  SDVQASF
         DVQ SF
Subjt:  SDVQASF

A0A2I4FY87 macrophage migration inhibitory factor homolog

1.6e-43

88.79

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Query:  MPTLNLFTNLPVDAVVAADILKDASKAVSKILGKSESYVMILLNGSTPIVFAGTEEPAAYGELISIGGLGPSVNGKLSSTIAEIIQTKLHIDSSRFYIKF
        MPTLNLFTNLPVDAVVA+DILKDA+KAV+KI+GK ESYVMILLNG  PI FAGTEEPAAYGELISIGGLGPSVNGKLSSTIAEI+QTKL IDSSRFYIKF
Subjt:  MPTLNLFTNLPVDAVVAADILKDASKAVSKILGKSESYVMILLNGSTPIVFAGTEEPAAYGELISIGGLGPSVNGKLSSTIAEIIQTKLHIDSSRFYIKF

Query:  SDVQASF
         DVQ SF
Subjt:  SDVQASF

A0A6J1BZZ0 macrophage migration inhibitory factor homolog

1.6e-43

86.92

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Query:  MPTLNLFTNLPVDAVVAADILKDASKAVSKILGKSESYVMILLNGSTPIVFAGTEEPAAYGELISIGGLGPSVNGKLSSTIAEIIQTKLHIDSSRFYIKF
        MPTLNLFTN+PVDAVVAADILKDA+KAVSKI+GK E+YVMILLNG TPI FAGTEEPAAYGELISIGGLGPSVNGKLSSTIAEI+QTKLHID SRFYIKF
Subjt:  MPTLNLFTNLPVDAVVAADILKDASKAVSKILGKSESYVMILLNGSTPIVFAGTEEPAAYGELISIGGLGPSVNGKLSSTIAEIIQTKLHIDSSRFYIKF

Query:  SDVQASF
         D + S+
Subjt:  SDVQASF

A0A6J1ED40 macrophage migration inhibitory factor homolog

5.5e-49

99.07

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Query:  MPTLNLFTNLPVDAVVAADILKDASKAVSKILGKSESYVMILLNGSTPIVFAGTEEPAAYGELISIGGLGPSVNGKLSSTIAEIIQTKLHIDSSRFYIKF
        MPTLNLFTNLPVDAVVAADILKDASKAVSKILGKSESYVMILLNGSTPIVFAGTEEP AYGELISIGGLGPSVNGKLSSTIAEIIQTKLHIDSSRFYIKF
Subjt:  MPTLNLFTNLPVDAVVAADILKDASKAVSKILGKSESYVMILLNGSTPIVFAGTEEPAAYGELISIGGLGPSVNGKLSSTIAEIIQTKLHIDSSRFYIKF

Query:  SDVQASF
        SDVQASF
Subjt:  SDVQASF

A0A6J1IEA5 macrophage migration inhibitory factor homolog

5.5e-49

99.07

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Query:  MPTLNLFTNLPVDAVVAADILKDASKAVSKILGKSESYVMILLNGSTPIVFAGTEEPAAYGELISIGGLGPSVNGKLSSTIAEIIQTKLHIDSSRFYIKF
        MPTLNLFTN PVDAVVAADILKDASKAVSKILGKSESYVMILLNGSTPIVFAGTEEPAAYGELISIGGLGPSVNGKLSSTIAEIIQTKLHIDSSRFYIKF
Subjt:  MPTLNLFTNLPVDAVVAADILKDASKAVSKILGKSESYVMILLNGSTPIVFAGTEEPAAYGELISIGGLGPSVNGKLSSTIAEIIQTKLHIDSSRFYIKF

Query:  SDVQASF
        SDVQASF
Subjt:  SDVQASF

SwissProt top hits

e value

%identity

Alignment

O44786 Macrophage migration inhibitory factor homolog

7.3e-14

41.51

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Query:  MPTLNLFTNLPVDAVVAADILKDASKAVSKILGKSESYVMILLNGSTPIVFAGTEEPAAYGELISIGGLGPSVNGKLSSTIAEIIQTKLHIDSSRFYIKF
        MP   + TN P D++ +A  LK A   V K LGK ESYV I +NG  P+VF G+E+P     L SIG +GP VN   +  + +++  +L I  +R YI+ 
Subjt:  MPTLNLFTNLPVDAVVAADILKDASKAVSKILGKSESYVMILLNGSTPIVFAGTEEPAAYGELISIGGLGPSVNGKLSSTIAEIIQTKLHIDSSRFYIKF

Query:  SDVQAS
         D++AS
Subjt:  SDVQAS

P81529 Macrophage migration inhibitory factor homolog

4.9e-10

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Query:  MPTLNLFTNLPVDAVVAADILKDASKAVSKILGKSESYVMILLNGSTPIVFAGTEEPAAYGELISIGGLGPSVNGKLSSTIAEIIQTKLHIDSSRFYIKF
        MP   L TN+     V +D L   S  V  IL K  SYV + +N    + F G+ +PAA+G L+SIGG+ PS N   S+ + + +  KL I  +R YI F
Subjt:  MPTLNLFTNLPVDAVVAADILKDASKAVSKILGKSESYVMILLNGSTPIVFAGTEEPAAYGELISIGGLGPSVNGKLSSTIAEIIQTKLHIDSSRFYIKF

P81748 Macrophage migration inhibitory factor homolog

1.5e-14

38.68

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Query:  MPTLNLFTNLPVDAVVAADILKDASKAVSKILGKSESYVMILLNGSTPIVFAGTEEPAAYGELISIGGLGPSVNGKLSSTIAEIIQTKLHIDSSRFYIKF
        MP     TN+P +  ++ D LK  SK ++ +LGK ESYV + +NG   I F GT+ PA +G+L+S+GG+G   N   S+ + + +   L I  +R YI F
Subjt:  MPTLNLFTNLPVDAVVAADILKDASKAVSKILGKSESYVMILLNGSTPIVFAGTEEPAAYGELISIGGLGPSVNGKLSSTIAEIIQTKLHIDSSRFYIKF

Query:  SDVQAS
         D++ S
Subjt:  SDVQAS

P91850 Macrophage migration inhibitory factor homolog

3.8e-15

42.45

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Query:  MPTLNLFTNLPVDAVVAADILKDASKAVSKILGKSESYVMILLNGSTPIVFAGTEEPAAYGELISIGGLGPSVNGKLSSTIAEIIQTKLHIDSSRFYIKF
        MP   + TN+P +++ +A  LK AS  V+K LGK ESYV I +NG   +VF G+E+P A   L SIG +GP VN   +  + +++  +L I  +R YI+F
Subjt:  MPTLNLFTNLPVDAVVAADILKDASKAVSKILGKSESYVMILLNGSTPIVFAGTEEPAAYGELISIGGLGPSVNGKLSSTIAEIIQTKLHIDSSRFYIKF

Query:  SDVQAS
         D++AS
Subjt:  SDVQAS

Q02960 Macrophage migration inhibitory factor

5.0e-07

28.3

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Query:  MPTLNLFTNLPVDAVVAADILKDASKAVSKILGKSESYVMILLNGSTPIVFAGTEEPAAYGELISIGGLGPSVNGKLSSTIAEIIQTKLHIDSSRFYIKF
        MP   + TN+  DA V   +L + ++ ++K  GK   Y+ + +     + F G+ +P A   L SIG +G   N   +  + ++I   LH+ + R YI +
Subjt:  MPTLNLFTNLPVDAVVAADILKDASKAVSKILGKSESYVMILLNGSTPIVFAGTEEPAAYGELISIGGLGPSVNGKLSSTIAEIIQTKLHIDSSRFYIKF

Query:  SDVQAS
         D+ A+
Subjt:  SDVQAS

Arabidopsis top hits

e value

%identity

Alignment

AT3G51660.1 Tautomerase/MIF superfamily protein

3.6e-16

38.94

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Query:  MPTLNLFTNLPVDAVVAADILKDASKAVSKILGKSESYVMILLNGSTPIVFAGTEEPAAYGELISIGGLGPSVNGKLSSTIAEIIQTKLHIDSSRFYIKF
        MP L + TN+  D V       + +KAV+ I+G+ ++ VM++L GS  IVF G +E AAY E++S+GG+   V  +L +T+  I+ T   I  +RF  K 
Subjt:  MPTLNLFTNLPVDAVVAADILKDASKAVSKILGKSESYVMILLNGSTPIVFAGTEEPAAYGELISIGGLGPSVNGKLSSTIAEIIQTKLHIDSSRFYIKF

Query:  SDVQASFSRPSKL
         D+  S   PSKL
Subjt:  SDVQASFSRPSKL

AT5G01650.1 Tautomerase/MIF superfamily protein

6.3e-29

56.07

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Query:  MPTLNLFTNLPVDAVVAADILKDASKAVSKILGKSESYVMILLNGSTPIVFAGTEEPAAYGELISIGGLGPSVNGKLSSTIAEIIQTKLHIDSSRFYIKF
        MP LNL TN+ +D V  + IL +AS  V+KI+GK E+YVMI+L GS P+ F GTE+PAAYGEL+SIGGL   VN KLS+ ++ I++TKL +  SRF++KF
Subjt:  MPTLNLFTNLPVDAVVAADILKDASKAVSKILGKSESYVMILLNGSTPIVFAGTEEPAAYGELISIGGLGPSVNGKLSSTIAEIIQTKLHIDSSRFYIKF

Query:  SDVQASF
         D + SF
Subjt:  SDVQASF

AT5G01650.2 Tautomerase/MIF superfamily protein

9.1e-28

55.77

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Query:  MPTLNLFTNLPVDAVVAADILKDASKAVSKILGKSESYVMILLNGSTPIVFAGTEEPAAYGELISIGGLGPSVNGKLSSTIAEIIQTKLHIDSSRFYIKF
        MP LNL TN+ +D V  + IL +AS  V+KI+GK E+YVMI+L GS P+ F GTE+PAAYGEL+SIGGL   VN KLS+ ++ I++TKL +  SRF++KF
Subjt:  MPTLNLFTNLPVDAVVAADILKDASKAVSKILGKSESYVMILLNGSTPIVFAGTEEPAAYGELISIGGLGPSVNGKLSSTIAEIIQTKLHIDSSRFYIKF

Query:  SDVQ
         D +
Subjt:  SDVQ

AT5G57170.1 Tautomerase/MIF superfamily protein

1.9e-41

78.5

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Query:  MPTLNLFTNLPVDAVVAADILKDASKAVSKILGKSESYVMILLNGSTPIVFAGTEEPAAYGELISIGGLGPSVNGKLSSTIAEIIQTKLHIDSSRFYIKF
        MPTLNLFTN+PVDAV  +DILKDA+KAV+KI+GK ESYVMILLN   PI FAGTEEPAAYGELISIGGLGP VNGKLS TI+EI+Q KL IDSSRFYIKF
Subjt:  MPTLNLFTNLPVDAVVAADILKDASKAVSKILGKSESYVMILLNGSTPIVFAGTEEPAAYGELISIGGLGPSVNGKLSSTIAEIIQTKLHIDSSRFYIKF

Query:  SDVQASF
         D    F
Subjt:  SDVQASF

AT5G57170.2 Tautomerase/MIF superfamily protein

1.9e-41

79.25

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Query:  MPTLNLFTNLPVDAVVAADILKDASKAVSKILGKSESYVMILLNGSTPIVFAGTEEPAAYGELISIGGLGPSVNGKLSSTIAEIIQTKLHIDSSRFYIKF
        MPTLNLFTN+PVDAV  +DILKDA+KAV+KI+GK ESYVMILLN   PI FAGTEEPAAYGELISIGGLGP VNGKLS TI+EI+Q KL IDSSRFYIKF
Subjt:  MPTLNLFTNLPVDAVVAADILKDASKAVSKILGKSESYVMILLNGSTPIVFAGTEEPAAYGELISIGGLGPSVNGKLSSTIAEIIQTKLHIDSSRFYIKF

Query:  SDVQAS
         D   S
Subjt:  SDVQAS

Sequences

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CDS sequence

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ATGCCCACTTTGAATTTGTTCACGAATCTCCCAGTTGATGCCGTGGTGGCTGCTGACATCCTCAAGGACGCATCGAAAGCCGTTTCTAAAATTCTCGGGAAATCTGAATC
TTATGTGATGATCTTGCTGAATGGTAGCACGCCAATCGTATTTGCTGGCACGGAAGAGCCAGCCGCGTATGGAGAATTGATATCTATTGGAGGCCTTGGACCAAGCGTGA
ATGGAAAACTTAGCTCAACAATTGCTGAGATTATTCAGACTAAGCTCCATATTGATAGCTCCCGTTTCTATATCAAATTTTCCGATGTTCAGGCAAGTTTTTCTCGTCCT
TCCAAATTGTTGAGCACATATATAAAAGGCTGGATA

mRNA sequence

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Protein sequence

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MPTLNLFTNLPVDAVVAADILKDASKAVSKILGKSESYVMILLNGSTPIVFAGTEEPAAYGELISIGGLGPSVNGKLSSTIAEIIQTKLHIDSSRFYIKFSDVQASFSRP
SKLLSTYIKGWI

Carg09053 (gene) of Silver-seed gourd (SMH-JMG-627) v2 genome