CuGenDBv2

Gene ID	Carg11834
Organism	Cucurbita argyrosperma subsp. argyrosperma cv. SMH-JMG-627 (Silver-seed gourd (SMH-JMG-627) v2)
Description	Uroporphyrinogen-III synthase
Genome location	Carg_Chr05:881357..884340
RNA-Seq Expression	Carg11834
Synteny	Carg11834
Gene Ontology terms	GO:0006780 - uroporphyrinogen III biosynthetic process (biological process) GO:0006782 - protoporphyrinogen IX biosynthetic process (biological process) GO:0009507 - chloroplast (cellular component) GO:0004852 - uroporphyrinogen-III synthase activity (molecular function)
InterPro domains	IPR003754 - Tetrapyrrole biosynthesis, uroporphyrinogen III synthase IPR036108 - Tetrapyrrole biosynthesis, uroporphyrinogen III synthase superfamily IPR039793 - Uroporphyrinogen-III synthase

Homology

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GenBank top hits

e value

%identity

Alignment

KAG6598391.1 Uroporphyrinogen-III synthase, chloroplastic, partial [Cucurbita argyrosperma subsp. sororia]

2.4e-92

100

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Query:  MPKVRIGVVGAGTANIFDEMLQSSNLLEVAFAPSKAIGKVLASELPKLGNTKCSVLYPASTKASNDIEEGLSNRGFEVMRLNTYTTSPVDYVDQFILEQA
        MPKVRIGVVGAGTANIFDEMLQSSNLLEVAFAPSKAIGKVLASELPKLGNTKCSVLYPASTKASNDIEEGLSNRGFEVMRLNTYTTSPVDYVDQFILEQA
Subjt:  MPKVRIGVVGAGTANIFDEMLQSSNLLEVAFAPSKAIGKVLASELPKLGNTKCSVLYPASTKASNDIEEGLSNRGFEVMRLNTYTTSPVDYVDQFILEQA

Query:  RSLPVVTVASPSAIRAWVNLISEPKEWEKSLACIGETTAAAAKRLGLKNIYYPKNPGLEGWVDSILEALRSEAQVV
        RSLPVVTVASPSAIRAWVNLISEPKEWEKSLACIGETTAAAAKRLGLKNIYYPKNPGLEGWVDSILEALRSEAQVV
Subjt:  RSLPVVTVASPSAIRAWVNLISEPKEWEKSLACIGETTAAAAKRLGLKNIYYPKNPGLEGWVDSILEALRSEAQVV

KAG7029354.1 Uroporphyrinogen-III synthase, chloroplastic, partial [Cucurbita argyrosperma subsp. argyrosperma]

2.4e-92

100

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Query:  MPKVRIGVVGAGTANIFDEMLQSSNLLEVAFAPSKAIGKVLASELPKLGNTKCSVLYPASTKASNDIEEGLSNRGFEVMRLNTYTTSPVDYVDQFILEQA
        MPKVRIGVVGAGTANIFDEMLQSSNLLEVAFAPSKAIGKVLASELPKLGNTKCSVLYPASTKASNDIEEGLSNRGFEVMRLNTYTTSPVDYVDQFILEQA
Subjt:  MPKVRIGVVGAGTANIFDEMLQSSNLLEVAFAPSKAIGKVLASELPKLGNTKCSVLYPASTKASNDIEEGLSNRGFEVMRLNTYTTSPVDYVDQFILEQA

Query:  RSLPVVTVASPSAIRAWVNLISEPKEWEKSLACIGETTAAAAKRLGLKNIYYPKNPGLEGWVDSILEALRSEAQVV
        RSLPVVTVASPSAIRAWVNLISEPKEWEKSLACIGETTAAAAKRLGLKNIYYPKNPGLEGWVDSILEALRSEAQVV
Subjt:  RSLPVVTVASPSAIRAWVNLISEPKEWEKSLACIGETTAAAAKRLGLKNIYYPKNPGLEGWVDSILEALRSEAQVV

XP_022962039.1 uroporphyrinogen-III synthase, chloroplastic-like [Cucurbita moschata]

7.1e-92

99.43

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Query:  MPKVRIGVVGAGTANIFDEMLQSSNLLEVAFAPSKAIGKVLASELPKLGNTKCSVLYPASTKASNDIEEGLSNRGFEVMRLNTYTTSPVDYVDQFILEQA
        MPKVRIGVVGAGTANIFDE+LQSSNLLEVAFAPSKAIGKVLASELPKLGNTKCSVLYPASTKASNDIEEGLSNRGFEVMRLNTYTTSPVDYVDQFILEQA
Subjt:  MPKVRIGVVGAGTANIFDEMLQSSNLLEVAFAPSKAIGKVLASELPKLGNTKCSVLYPASTKASNDIEEGLSNRGFEVMRLNTYTTSPVDYVDQFILEQA

Query:  RSLPVVTVASPSAIRAWVNLISEPKEWEKSLACIGETTAAAAKRLGLKNIYYPKNPGLEGWVDSILEALRSEAQVV
        RSLPVVTVASPSAIRAWVNLISEPKEWEKSLACIGETTAAAAKRLGLKNIYYPKNPGLEGWVDSILEALRSEAQVV
Subjt:  RSLPVVTVASPSAIRAWVNLISEPKEWEKSLACIGETTAAAAKRLGLKNIYYPKNPGLEGWVDSILEALRSEAQVV

XP_022996969.1 uroporphyrinogen-III synthase, chloroplastic-like [Cucurbita maxima]

1.6e-91

98.86

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Query:  MPKVRIGVVGAGTANIFDEMLQSSNLLEVAFAPSKAIGKVLASELPKLGNTKCSVLYPASTKASNDIEEGLSNRGFEVMRLNTYTTSPVDYVDQFILEQA
        MPKVRIGVVGAGTANIFDE+LQSSNLLEVAFAPSKAIGKVLASELPKLGNTKCSVLYPASTKASNDIEEGLSNRGFEVMRLNTYTT+PVDYVDQFILEQA
Subjt:  MPKVRIGVVGAGTANIFDEMLQSSNLLEVAFAPSKAIGKVLASELPKLGNTKCSVLYPASTKASNDIEEGLSNRGFEVMRLNTYTTSPVDYVDQFILEQA

Query:  RSLPVVTVASPSAIRAWVNLISEPKEWEKSLACIGETTAAAAKRLGLKNIYYPKNPGLEGWVDSILEALRSEAQVV
        RSLPVVTVASPSAIRAWVNLISEPKEWEKSLACIGETTAAAAKRLGLKNIYYPKNPGLEGWVDSILEALRSEAQVV
Subjt:  RSLPVVTVASPSAIRAWVNLISEPKEWEKSLACIGETTAAAAKRLGLKNIYYPKNPGLEGWVDSILEALRSEAQVV

XP_023547155.1 uroporphyrinogen-III synthase, chloroplastic-like [Cucurbita pepo subsp. pepo]

6.6e-90

97.73

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Query:  MPKVRIGVVGAGTANIFDEMLQSSNLLEVAFAPSKAIGKVLASELPKLGNTKCSVLYPASTKASNDIEEGLSNRGFEVMRLNTYTTSPVDYVDQFILEQA
        MPKVRIGVVGAGTANIFDE+LQSSNLLEVAFAPSKAIGKVLASELPKLGNTKCSVLYPASTKASNDIEE LSNRGFEVMRLNTYTT+PVDYVDQFILEQA
Subjt:  MPKVRIGVVGAGTANIFDEMLQSSNLLEVAFAPSKAIGKVLASELPKLGNTKCSVLYPASTKASNDIEEGLSNRGFEVMRLNTYTTSPVDYVDQFILEQA

Query:  RSLPVVTVASPSAIRAWVNLISEPKEWEKSLACIGETTAAAAKRLGLKNIYYPKNPGLEGWVDSILEALRSEAQVV
        RSLPVVTVASPSAI AWVNLISEPKEWEKSLACIGETTAAAAKRLGLKNIYYPKNPGLEGWVDSILEALRSEAQVV
Subjt:  RSLPVVTVASPSAIRAWVNLISEPKEWEKSLACIGETTAAAAKRLGLKNIYYPKNPGLEGWVDSILEALRSEAQVV

TrEMBL top hits

e value

%identity

Alignment

A0A0A0LLB2 Uroporphyrinogen-III synthase

1.6e-86

93.18

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Query:  MPKVRIGVVGAGTANIFDEMLQSSNLLEVAFAPSKAIGKVLASELPKLGNTKCSVLYPASTKASNDIEEGLSNRGFEVMRLNTYTTSPVDYVDQFILEQA
        MPKVRIGVVGAGTANIF+E+LQSS LLEVAFAPSKAIGKVLASELPKLGNTKCSVLYPASTKASNDIEE LSNRGFEV RLNTYTT+PVDYVDQ ILEQA
Subjt:  MPKVRIGVVGAGTANIFDEMLQSSNLLEVAFAPSKAIGKVLASELPKLGNTKCSVLYPASTKASNDIEEGLSNRGFEVMRLNTYTTSPVDYVDQFILEQA

Query:  RSLPVVTVASPSAIRAWVNLISEPKEWEKSLACIGETTAAAAKRLGLKNIYYPKNPGLEGWVDSILEALRSEAQVV
        RSLPVVTVASPSA+RAWVNLIS+PKEW+KSLACIGETTAAAA RLGLKN+YYPKNPGLEGWVDSILEALRSEAQVV
Subjt:  RSLPVVTVASPSAIRAWVNLISEPKEWEKSLACIGETTAAAAKRLGLKNIYYPKNPGLEGWVDSILEALRSEAQVV

A0A1S3BBN0 Uroporphyrinogen-III synthase

5.3e-85

91.48

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Query:  MPKVRIGVVGAGTANIFDEMLQSSNLLEVAFAPSKAIGKVLASELPKLGNTKCSVLYPASTKASNDIEEGLSNRGFEVMRLNTYTTSPVDYVDQFILEQA
        MPKVRIGVVGAGTANIF+E+LQSS LLEVAFAPSKAIGKVLASELPKLGNTKCSVLYPASTKASNDIEE LSNRGFEV RLNTYTT+PVDYVDQ I EQA
Subjt:  MPKVRIGVVGAGTANIFDEMLQSSNLLEVAFAPSKAIGKVLASELPKLGNTKCSVLYPASTKASNDIEEGLSNRGFEVMRLNTYTTSPVDYVDQFILEQA

Query:  RSLPVVTVASPSAIRAWVNLISEPKEWEKSLACIGETTAAAAKRLGLKNIYYPKNPGLEGWVDSILEALRSEAQVV
        RSLPVVTVASPSA+RAWVNLI +PKEW+KSLACIGETTAAAA RLGLKN+YYPKNPGLEGWVDSILEALRSEAQ+V
Subjt:  RSLPVVTVASPSAIRAWVNLISEPKEWEKSLACIGETTAAAAKRLGLKNIYYPKNPGLEGWVDSILEALRSEAQVV

A0A5A7V583 Uroporphyrinogen-III synthase

1.8e-85

91.48

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Query:  MPKVRIGVVGAGTANIFDEMLQSSNLLEVAFAPSKAIGKVLASELPKLGNTKCSVLYPASTKASNDIEEGLSNRGFEVMRLNTYTTSPVDYVDQFILEQA
        MPKVRIGVVGAGTANIF+E+LQSS LLEVAFAPSKAIGKVLASELPKLGNTKCSVLYPASTKASNDIEE LSNRGFEV RLNTYTT+PVDYVDQ ILEQA
Subjt:  MPKVRIGVVGAGTANIFDEMLQSSNLLEVAFAPSKAIGKVLASELPKLGNTKCSVLYPASTKASNDIEEGLSNRGFEVMRLNTYTTSPVDYVDQFILEQA

Query:  RSLPVVTVASPSAIRAWVNLISEPKEWEKSLACIGETTAAAAKRLGLKNIYYPKNPGLEGWVDSILEALRSEAQVV
        RSLPVVTVASPSA+RAWVNLI +PKEW+KSLACIGETTAAAA +LGLKN+YYPKNPGLEGWVDSILEALRSEAQ+V
Subjt:  RSLPVVTVASPSAIRAWVNLISEPKEWEKSLACIGETTAAAAKRLGLKNIYYPKNPGLEGWVDSILEALRSEAQVV

A0A6J1HDZ7 Uroporphyrinogen-III synthase

3.4e-92

99.43

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Query:  MPKVRIGVVGAGTANIFDEMLQSSNLLEVAFAPSKAIGKVLASELPKLGNTKCSVLYPASTKASNDIEEGLSNRGFEVMRLNTYTTSPVDYVDQFILEQA
        MPKVRIGVVGAGTANIFDE+LQSSNLLEVAFAPSKAIGKVLASELPKLGNTKCSVLYPASTKASNDIEEGLSNRGFEVMRLNTYTTSPVDYVDQFILEQA
Subjt:  MPKVRIGVVGAGTANIFDEMLQSSNLLEVAFAPSKAIGKVLASELPKLGNTKCSVLYPASTKASNDIEEGLSNRGFEVMRLNTYTTSPVDYVDQFILEQA

Query:  RSLPVVTVASPSAIRAWVNLISEPKEWEKSLACIGETTAAAAKRLGLKNIYYPKNPGLEGWVDSILEALRSEAQVV
        RSLPVVTVASPSAIRAWVNLISEPKEWEKSLACIGETTAAAAKRLGLKNIYYPKNPGLEGWVDSILEALRSEAQVV
Subjt:  RSLPVVTVASPSAIRAWVNLISEPKEWEKSLACIGETTAAAAKRLGLKNIYYPKNPGLEGWVDSILEALRSEAQVV

A0A6J1KA58 Uroporphyrinogen-III synthase

7.6e-92

98.86

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Query:  MPKVRIGVVGAGTANIFDEMLQSSNLLEVAFAPSKAIGKVLASELPKLGNTKCSVLYPASTKASNDIEEGLSNRGFEVMRLNTYTTSPVDYVDQFILEQA
        MPKVRIGVVGAGTANIFDE+LQSSNLLEVAFAPSKAIGKVLASELPKLGNTKCSVLYPASTKASNDIEEGLSNRGFEVMRLNTYTT+PVDYVDQFILEQA
Subjt:  MPKVRIGVVGAGTANIFDEMLQSSNLLEVAFAPSKAIGKVLASELPKLGNTKCSVLYPASTKASNDIEEGLSNRGFEVMRLNTYTTSPVDYVDQFILEQA

Query:  RSLPVVTVASPSAIRAWVNLISEPKEWEKSLACIGETTAAAAKRLGLKNIYYPKNPGLEGWVDSILEALRSEAQVV
        RSLPVVTVASPSAIRAWVNLISEPKEWEKSLACIGETTAAAAKRLGLKNIYYPKNPGLEGWVDSILEALRSEAQVV
Subjt:  RSLPVVTVASPSAIRAWVNLISEPKEWEKSLACIGETTAAAAKRLGLKNIYYPKNPGLEGWVDSILEALRSEAQVV

SwissProt top hits

e value

%identity

Alignment

O48721 Uroporphyrinogen-III synthase, chloroplastic

3.3e-60

65.9

Show/hide

Query:  PKVRIGVVGAGTANIFDEMLQSSN-LLEVAFAPSKAIGKVLASELPKLGNTKCSVLYPASTKASNDIEEGLSNRGFEVMRLNTYTTSPVDYVDQFILEQA
        P+V+IGVVGAGTA +F+E ++S++ LL VAF PSKA GKVLASELP+    + SVLYPAS KA NDI EGLS RGFEV+RLNTYTT PV  VD  +L+QA
Subjt:  PKVRIGVVGAGTANIFDEMLQSSN-LLEVAFAPSKAIGKVLASELPKLGNTKCSVLYPASTKASNDIEEGLSNRGFEVMRLNTYTTSPVDYVDQFILEQA

Query:  RSLPVVTVASPSAIRAWVNLISEPKEWEKSLACIGETTAAAAKRLGLKNIYYPKNPGLEGWVDSILEALRSEA
         S PV++VASPSA+RAW++LI   ++W   +ACIGETTA+AA+RLGLKN+YYP+ PGLEGWV+SI+EAL + A
Subjt:  RSLPVVTVASPSAIRAWVNLISEPKEWEKSLACIGETTAAAAKRLGLKNIYYPKNPGLEGWVDSILEALRSEA

Q10QR9 Uroporphyrinogen-III synthase, chloroplastic

1.6e-59

65.52

Show/hide

Query:  PKVRIGVVGAGTANIFDEMLQ-SSNLLEVAFAPSKAIGKVLASELPKLGNTKCSVLYPASTKASNDIEEGLSNRGFEVMRLNTYTTSPVDYVDQFILEQA
        PKVRI VVGAGT  +FDE++Q +   LEVAF+PSKA+GK LASELP+   T C VLYPAS KA ++I+ GLSNRGFEV RLNTYTT  V  VD  IL+ A
Subjt:  PKVRIGVVGAGTANIFDEMLQ-SSNLLEVAFAPSKAIGKVLASELPKLGNTKCSVLYPASTKASNDIEEGLSNRGFEVMRLNTYTTSPVDYVDQFILEQA

Query:  RSLPVVTVASPSAIRAWVNLISEPKEWEKSLACIGETTAAAAKRLGLKNIYYPKNPGLEGWVDSILEALRSEAQ
         S PVV VASPSA+RAW+NL S+   W  ++ACIGETTA+AAK+ GLK+IYYP  PGL+GWV+SILEALR+  Q
Subjt:  RSLPVVTVASPSAIRAWVNLISEPKEWEKSLACIGETTAAAAKRLGLKNIYYPKNPGLEGWVDSILEALRSEAQ

Arabidopsis top hits

e value

%identity

Alignment

AT2G26540.1 uroporphyrinogen-III synthase family protein

2.4e-61

65.9

Show/hide

Query:  PKVRIGVVGAGTANIFDEMLQSSN-LLEVAFAPSKAIGKVLASELPKLGNTKCSVLYPASTKASNDIEEGLSNRGFEVMRLNTYTTSPVDYVDQFILEQA
        P+V+IGVVGAGTA +F+E ++S++ LL VAF PSKA GKVLASELP+    + SVLYPAS KA NDI EGLS RGFEV+RLNTYTT PV  VD  +L+QA
Subjt:  PKVRIGVVGAGTANIFDEMLQSSN-LLEVAFAPSKAIGKVLASELPKLGNTKCSVLYPASTKASNDIEEGLSNRGFEVMRLNTYTTSPVDYVDQFILEQA

Query:  RSLPVVTVASPSAIRAWVNLISEPKEWEKSLACIGETTAAAAKRLGLKNIYYPKNPGLEGWVDSILEALRSEA
         S PV++VASPSA+RAW++LI   ++W   +ACIGETTA+AA+RLGLKN+YYP+ PGLEGWV+SI+EAL + A
Subjt:  RSLPVVTVASPSAIRAWVNLISEPKEWEKSLACIGETTAAAAKRLGLKNIYYPKNPGLEGWVDSILEALRSEA

Sequences

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CDS sequence

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ATGCCAAAAGTTAGAATAGGTGTTGTTGGAGCTGGTACAGCTAACATTTTTGACGAAATGTTGCAATCATCAAACTTACTTGAAGTGGCGTTTGCACCCTCAAAAGCAAT
AGGCAAGGTCTTGGCTTCCGAGCTTCCGAAGTTAGGGAATACAAAATGCAGTGTCTTATATCCTGCTTCTACCAAAGCAAGCAATGATATTGAGGAAGGCCTTTCAAATC
GTGGATTTGAGGTCATGAGGCTCAACACCTATACTACGTCACCTGTTGATTACGTTGATCAATTCATTCTCGAGCAAGCACGTTCATTGCCTGTTGTCACAGTGGCTTCA
CCTTCTGCAATTCGCGCATGGGTCAACCTTATTTCCGAGCCGAAGGAGTGGGAAAAATCACTTGCCTGTATTGGGGAAACAACTGCAGCAGCCGCAAAAAGATTAGGATT
GAAAAACATATACTACCCCAAGAATCCTGGATTGGAAGGGTGGGTTGACAGTATATTGGAAGCGCTAAGATCAGAAGCTCAAGTTGTTTGA

mRNA sequence

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Protein sequence

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MPKVRIGVVGAGTANIFDEMLQSSNLLEVAFAPSKAIGKVLASELPKLGNTKCSVLYPASTKASNDIEEGLSNRGFEVMRLNTYTTSPVDYVDQFILEQARSLPVVTVAS
PSAIRAWVNLISEPKEWEKSLACIGETTAAAAKRLGLKNIYYPKNPGLEGWVDSILEALRSEAQVV

Carg11834 (gene) of Silver-seed gourd (SMH-JMG-627) v2 genome