CuGenDBv2

Gene ID	Carg20228
Organism	Cucurbita argyrosperma subsp. argyrosperma cv. SMH-JMG-627 (Silver-seed gourd (SMH-JMG-627) v2)
Description	Non-specific serine/threonine protein kinase
Genome location	Carg_Chr11:508670..515224
RNA-Seq Expression	Carg20228
Synteny	Carg20228
Gene Ontology terms	GO:0006281 - DNA repair (biological process) GO:0006468 - protein phosphorylation (biological process) GO:0005634 - nucleus (cellular component) GO:0004674 - protein serine/threonine kinase activity (molecular function) GO:0004712 - protein serine/threonine/tyrosine kinase activity (molecular function) GO:0005524 - ATP binding (molecular function) GO:0106310 - protein serine kinase activity (molecular function)
InterPro domains	IPR038980 - Serine/threonine-protein kinase ATM, plant

Homology

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GenBank top hits

e value

%identity

Alignment

KAG6587470.1 Serine/threonine-protein kinase ATM, partial [Cucurbita argyrosperma subsp. sororia]

2.8e-98

95.83

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Query:  SLVLYGRLQISLTRADDERFFVEQLLDVLYKDLDQSSISSVGVPWSDTNKDDKFGTLSSSHCGLVELAAAVLYRACVTSTKAISTEKRVKRDPASVHLKE
        +LVLYGRLQISLTRADDERFFVEQLLDVLYKDLDQSSISSVGVPWSDTNKDDKFGTLSSSHCGLVELAAAVLYRACVTSTKAISTEKRVKRDPASVHLKE
Subjt:  SLVLYGRLQISLTRADDERFFVEQLLDVLYKDLDQSSISSVGVPWSDTNKDDKFGTLSSSHCGLVELAAAVLYRACVTSTKAISTEKRVKRDPASVHLKE

Query:  ELAKGKWLWNAAFCCLVRNYHSRISKDLFTYWFEAICSGFERILKDANVGHSYDGLLWTLRSLQELSSVLIDSTERSESSSEEKVCSSFHCI
        ELAKGKWLWNAAFCCLVRNYHSRISKDLFTYWFEAICSGFERILKDANVGHSYDGLLWTLRSLQELSSVLIDSTERSESSSEEK+   +  I
Subjt:  ELAKGKWLWNAAFCCLVRNYHSRISKDLFTYWFEAICSGFERILKDANVGHSYDGLLWTLRSLQELSSVLIDSTERSESSSEEKVCSSFHCI

KAG7021454.1 Serine/threonine-protein kinase ATM, partial [Cucurbita argyrosperma subsp. argyrosperma]

3.1e-158

100

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Query:  MPFRLPDHPFLSAILMSSTDSMQSQKFHQFELFHPLLTSEHSNRKQRIRMVTIPETSQDIVLKAIFGRSLVLYGRLQISLTRADDERFFVEQLLDVLYKD
        MPFRLPDHPFLSAILMSSTDSMQSQKFHQFELFHPLLTSEHSNRKQRIRMVTIPETSQDIVLKAIFGRSLVLYGRLQISLTRADDERFFVEQLLDVLYKD
Subjt:  MPFRLPDHPFLSAILMSSTDSMQSQKFHQFELFHPLLTSEHSNRKQRIRMVTIPETSQDIVLKAIFGRSLVLYGRLQISLTRADDERFFVEQLLDVLYKD

Query:  LDQSSISSVGVPWSDTNKDDKFGTLSSSHCGLVELAAAVLYRACVTSTKAISTEKRVKRDPASVHLKEELAKGKWLWNAAFCCLVRNYHSRISKDLFTYW
        LDQSSISSVGVPWSDTNKDDKFGTLSSSHCGLVELAAAVLYRACVTSTKAISTEKRVKRDPASVHLKEELAKGKWLWNAAFCCLVRNYHSRISKDLFTYW
Subjt:  LDQSSISSVGVPWSDTNKDDKFGTLSSSHCGLVELAAAVLYRACVTSTKAISTEKRVKRDPASVHLKEELAKGKWLWNAAFCCLVRNYHSRISKDLFTYW

Query:  FEAICSGFERILKDANVGHSYDGLLWTLRSLQELSSVLIDSTERSESSSEEKVCSSFHCILILLFLFLFCMGKQKKCQAKRGD
        FEAICSGFERILKDANVGHSYDGLLWTLRSLQELSSVLIDSTERSESSSEEKVCSSFHCILILLFLFLFCMGKQKKCQAKRGD
Subjt:  FEAICSGFERILKDANVGHSYDGLLWTLRSLQELSSVLIDSTERSESSSEEKVCSSFHCILILLFLFLFCMGKQKKCQAKRGD

XP_022928409.1 serine/threonine-protein kinase ATM isoform X1 [Cucurbita moschata]

2.8e-98

95.83

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Query:  SLVLYGRLQISLTRADDERFFVEQLLDVLYKDLDQSSISSVGVPWSDTNKDDKFGTLSSSHCGLVELAAAVLYRACVTSTKAISTEKRVKRDPASVHLKE
        +LVLYGRLQISLTRADDERFFVEQLLDVLYKDLDQSSISSVGVPWSDTNKDDKFGTLSSSHCGLVELAAAVLYRACVTSTKAISTEKRVKRDPASVHLKE
Subjt:  SLVLYGRLQISLTRADDERFFVEQLLDVLYKDLDQSSISSVGVPWSDTNKDDKFGTLSSSHCGLVELAAAVLYRACVTSTKAISTEKRVKRDPASVHLKE

Query:  ELAKGKWLWNAAFCCLVRNYHSRISKDLFTYWFEAICSGFERILKDANVGHSYDGLLWTLRSLQELSSVLIDSTERSESSSEEKVCSSFHCI
        ELAKGKWLWNAAFCCLVRNYHSRISKDLFTYWFEAICSGFERILKDANVGHSYDGLLWTLRSLQELSSVLIDSTERSESSSEEK+   +  I
Subjt:  ELAKGKWLWNAAFCCLVRNYHSRISKDLFTYWFEAICSGFERILKDANVGHSYDGLLWTLRSLQELSSVLIDSTERSESSSEEKVCSSFHCI

XP_022928417.1 serine/threonine-protein kinase ATM isoform X2 [Cucurbita moschata]

2.8e-98

95.83

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Query:  SLVLYGRLQISLTRADDERFFVEQLLDVLYKDLDQSSISSVGVPWSDTNKDDKFGTLSSSHCGLVELAAAVLYRACVTSTKAISTEKRVKRDPASVHLKE
        +LVLYGRLQISLTRADDERFFVEQLLDVLYKDLDQSSISSVGVPWSDTNKDDKFGTLSSSHCGLVELAAAVLYRACVTSTKAISTEKRVKRDPASVHLKE
Subjt:  SLVLYGRLQISLTRADDERFFVEQLLDVLYKDLDQSSISSVGVPWSDTNKDDKFGTLSSSHCGLVELAAAVLYRACVTSTKAISTEKRVKRDPASVHLKE

Query:  ELAKGKWLWNAAFCCLVRNYHSRISKDLFTYWFEAICSGFERILKDANVGHSYDGLLWTLRSLQELSSVLIDSTERSESSSEEKVCSSFHCI
        ELAKGKWLWNAAFCCLVRNYHSRISKDLFTYWFEAICSGFERILKDANVGHSYDGLLWTLRSLQELSSVLIDSTERSESSSEEK+   +  I
Subjt:  ELAKGKWLWNAAFCCLVRNYHSRISKDLFTYWFEAICSGFERILKDANVGHSYDGLLWTLRSLQELSSVLIDSTERSESSSEEKVCSSFHCI

XP_023004525.1 serine/threonine-protein kinase ATM isoform X2 [Cucurbita maxima]

1.8e-97

94.79

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Query:  SLVLYGRLQISLTRADDERFFVEQLLDVLYKDLDQSSISSVGVPWSDTNKDDKFGTLSSSHCGLVELAAAVLYRACVTSTKAISTEKRVKRDPASVHLKE
        +LVLYGRLQISLTRADDERFFVEQLLDVLYK+LDQSSISSVGVPWSDTNKDDKFGTLSSSHCGLVELAAAVLYRACVTSTKA+STEKRVKRDPASVHLKE
Subjt:  SLVLYGRLQISLTRADDERFFVEQLLDVLYKDLDQSSISSVGVPWSDTNKDDKFGTLSSSHCGLVELAAAVLYRACVTSTKAISTEKRVKRDPASVHLKE

Query:  ELAKGKWLWNAAFCCLVRNYHSRISKDLFTYWFEAICSGFERILKDANVGHSYDGLLWTLRSLQELSSVLIDSTERSESSSEEKVCSSFHCI
        ELAKGKWLWNAAFCCLVRNYHSRISKDLFTYWFEAICSGFERILKDANVGHSYDGLLWTLRSLQELSSVLIDSTERSESSSEEK+   +  I
Subjt:  ELAKGKWLWNAAFCCLVRNYHSRISKDLFTYWFEAICSGFERILKDANVGHSYDGLLWTLRSLQELSSVLIDSTERSESSSEEKVCSSFHCI

TrEMBL top hits

e value

%identity

Alignment

A0A1S3BWI4 serine/threonine-protein kinase ATM isoform X3

3.3e-89

87.05

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Query:  SLVLYGRLQISLTR-ADDERFFVEQLLDVLYKDLDQSSISSVGVPWSDTNKDDKFGTLSSSHCGLVELAAAVLYRACVTSTKAISTEKRVKRDPASVHLK
        +LVLYGRLQISLTR ADDE   +EQLLDVLYK+LDQSSI SVGVPWSD NKDDKFGTLSSSHCGLVELAAAVLYRACVTSTKAISTEKRVKRDPASVHLK
Subjt:  SLVLYGRLQISLTR-ADDERFFVEQLLDVLYKDLDQSSISSVGVPWSDTNKDDKFGTLSSSHCGLVELAAAVLYRACVTSTKAISTEKRVKRDPASVHLK

Query:  EELAKGKWLWNAAFCCLVRNYHSRISKDLFTYWFEAICSGFERILKDANVGHSYDGLLWTLRSLQELSSVLIDSTERSESSSEEKVCSSFHCI
        E L +GKWLWNAAFCCL++NYHSRISKDLFTYWFEAIC GFERILKDANVGHSYDGLLWTLRSLQELS VL+DSTERSESSSE+K+   +  I
Subjt:  EELAKGKWLWNAAFCCLVRNYHSRISKDLFTYWFEAICSGFERILKDANVGHSYDGLLWTLRSLQELSSVLIDSTERSESSSEEKVCSSFHCI

A0A6J1EJV2 Non-specific serine/threonine protein kinase

1.3e-98

95.83

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Query:  SLVLYGRLQISLTRADDERFFVEQLLDVLYKDLDQSSISSVGVPWSDTNKDDKFGTLSSSHCGLVELAAAVLYRACVTSTKAISTEKRVKRDPASVHLKE
        +LVLYGRLQISLTRADDERFFVEQLLDVLYKDLDQSSISSVGVPWSDTNKDDKFGTLSSSHCGLVELAAAVLYRACVTSTKAISTEKRVKRDPASVHLKE
Subjt:  SLVLYGRLQISLTRADDERFFVEQLLDVLYKDLDQSSISSVGVPWSDTNKDDKFGTLSSSHCGLVELAAAVLYRACVTSTKAISTEKRVKRDPASVHLKE

Query:  ELAKGKWLWNAAFCCLVRNYHSRISKDLFTYWFEAICSGFERILKDANVGHSYDGLLWTLRSLQELSSVLIDSTERSESSSEEKVCSSFHCI
        ELAKGKWLWNAAFCCLVRNYHSRISKDLFTYWFEAICSGFERILKDANVGHSYDGLLWTLRSLQELSSVLIDSTERSESSSEEK+   +  I
Subjt:  ELAKGKWLWNAAFCCLVRNYHSRISKDLFTYWFEAICSGFERILKDANVGHSYDGLLWTLRSLQELSSVLIDSTERSESSSEEKVCSSFHCI

A0A6J1EKR8 Non-specific serine/threonine protein kinase

1.3e-98

95.83

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Query:  SLVLYGRLQISLTRADDERFFVEQLLDVLYKDLDQSSISSVGVPWSDTNKDDKFGTLSSSHCGLVELAAAVLYRACVTSTKAISTEKRVKRDPASVHLKE
        +LVLYGRLQISLTRADDERFFVEQLLDVLYKDLDQSSISSVGVPWSDTNKDDKFGTLSSSHCGLVELAAAVLYRACVTSTKAISTEKRVKRDPASVHLKE
Subjt:  SLVLYGRLQISLTRADDERFFVEQLLDVLYKDLDQSSISSVGVPWSDTNKDDKFGTLSSSHCGLVELAAAVLYRACVTSTKAISTEKRVKRDPASVHLKE

Query:  ELAKGKWLWNAAFCCLVRNYHSRISKDLFTYWFEAICSGFERILKDANVGHSYDGLLWTLRSLQELSSVLIDSTERSESSSEEKVCSSFHCI
        ELAKGKWLWNAAFCCLVRNYHSRISKDLFTYWFEAICSGFERILKDANVGHSYDGLLWTLRSLQELSSVLIDSTERSESSSEEK+   +  I
Subjt:  ELAKGKWLWNAAFCCLVRNYHSRISKDLFTYWFEAICSGFERILKDANVGHSYDGLLWTLRSLQELSSVLIDSTERSESSSEEKVCSSFHCI

A0A6J1KUU2 Non-specific serine/threonine protein kinase

8.7e-98

94.79

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Query:  SLVLYGRLQISLTRADDERFFVEQLLDVLYKDLDQSSISSVGVPWSDTNKDDKFGTLSSSHCGLVELAAAVLYRACVTSTKAISTEKRVKRDPASVHLKE
        +LVLYGRLQISLTRADDERFFVEQLLDVLYK+LDQSSISSVGVPWSDTNKDDKFGTLSSSHCGLVELAAAVLYRACVTSTKA+STEKRVKRDPASVHLKE
Subjt:  SLVLYGRLQISLTRADDERFFVEQLLDVLYKDLDQSSISSVGVPWSDTNKDDKFGTLSSSHCGLVELAAAVLYRACVTSTKAISTEKRVKRDPASVHLKE

Query:  ELAKGKWLWNAAFCCLVRNYHSRISKDLFTYWFEAICSGFERILKDANVGHSYDGLLWTLRSLQELSSVLIDSTERSESSSEEKVCSSFHCI
        ELAKGKWLWNAAFCCLVRNYHSRISKDLFTYWFEAICSGFERILKDANVGHSYDGLLWTLRSLQELSSVLIDSTERSESSSEEK+   +  I
Subjt:  ELAKGKWLWNAAFCCLVRNYHSRISKDLFTYWFEAICSGFERILKDANVGHSYDGLLWTLRSLQELSSVLIDSTERSESSSEEKVCSSFHCI

A0A6J1KZS2 Non-specific serine/threonine protein kinase

8.7e-98

94.79

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Query:  SLVLYGRLQISLTRADDERFFVEQLLDVLYKDLDQSSISSVGVPWSDTNKDDKFGTLSSSHCGLVELAAAVLYRACVTSTKAISTEKRVKRDPASVHLKE
        +LVLYGRLQISLTRADDERFFVEQLLDVLYK+LDQSSISSVGVPWSDTNKDDKFGTLSSSHCGLVELAAAVLYRACVTSTKA+STEKRVKRDPASVHLKE
Subjt:  SLVLYGRLQISLTRADDERFFVEQLLDVLYKDLDQSSISSVGVPWSDTNKDDKFGTLSSSHCGLVELAAAVLYRACVTSTKAISTEKRVKRDPASVHLKE

Query:  ELAKGKWLWNAAFCCLVRNYHSRISKDLFTYWFEAICSGFERILKDANVGHSYDGLLWTLRSLQELSSVLIDSTERSESSSEEKVCSSFHCI
        ELAKGKWLWNAAFCCLVRNYHSRISKDLFTYWFEAICSGFERILKDANVGHSYDGLLWTLRSLQELSSVLIDSTERSESSSEEK+   +  I
Subjt:  ELAKGKWLWNAAFCCLVRNYHSRISKDLFTYWFEAICSGFERILKDANVGHSYDGLLWTLRSLQELSSVLIDSTERSESSSEEKVCSSFHCI

SwissProt top hits

e value

%identity

Alignment

Q9M3G7 Serine/threonine-protein kinase ATM

8.8e-47

52.48

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Query:  TSQDIVLKAIFGRSLVLYGRLQISLTR-ADDERFFVEQLLDVLYKDLDQSSISSVGVPWSDTNKDDKFGTLSSSHCGLVELAAAVLYRACVTSTKAISTE
        T+ D  LK I    LV YGRLQ++LTR + +    VEQLLDV+ ++LD  S SS    W DT KD+K G LSS    LVELAA V YRACV +++   +E
Subjt:  TSQDIVLKAIFGRSLVLYGRLQISLTR-ADDERFFVEQLLDVLYKDLDQSSISSVGVPWSDTNKDDKFGTLSSSHCGLVELAAAVLYRACVTSTKAISTE

Query:  KRVKRDPASVHLKEELAKGKWLWNAAFCCLVRNYHSRISKDLFTYWFEAICSGFERILKDANVGHSYDGLLWTLRSLQELSS------VLIDSTERSESS
        KR +R   ++ + + L +GKWLW AAF CLVRNY +RI+ DL  YWFEAIC+ F+R+L+DA++  SYDGLLWTLRSLQ LSS      + +D ++ S SS
Subjt:  KRVKRDPASVHLKEELAKGKWLWNAAFCCLVRNYHSRISKDLFTYWFEAICSGFERILKDANVGHSYDGLLWTLRSLQELSS------VLIDSTERSESS

Query:  SE
        SE
Subjt:  SE

Arabidopsis top hits

e value

%identity

Alignment

AT3G48190.1 ataxia-telangiectasia mutated

6.3e-48

52.48

Show/hide

Query:  TSQDIVLKAIFGRSLVLYGRLQISLTR-ADDERFFVEQLLDVLYKDLDQSSISSVGVPWSDTNKDDKFGTLSSSHCGLVELAAAVLYRACVTSTKAISTE
        T+ D  LK I    LV YGRLQ++LTR + +    VEQLLDV+ ++LD  S SS    W DT KD+K G LSS    LVELAA V YRACV +++   +E
Subjt:  TSQDIVLKAIFGRSLVLYGRLQISLTR-ADDERFFVEQLLDVLYKDLDQSSISSVGVPWSDTNKDDKFGTLSSSHCGLVELAAAVLYRACVTSTKAISTE

Query:  KRVKRDPASVHLKEELAKGKWLWNAAFCCLVRNYHSRISKDLFTYWFEAICSGFERILKDANVGHSYDGLLWTLRSLQELSS------VLIDSTERSESS
        KR +R   ++ + + L +GKWLW AAF CLVRNY +RI+ DL  YWFEAIC+ F+R+L+DA++  SYDGLLWTLRSLQ LSS      + +D ++ S SS
Subjt:  KRVKRDPASVHLKEELAKGKWLWNAAFCCLVRNYHSRISKDLFTYWFEAICSGFERILKDANVGHSYDGLLWTLRSLQELSS------VLIDSTERSESS

Query:  SE
        SE
Subjt:  SE

Sequences

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CDS sequence

Show/hide CDS sequence

ATGCCCTTTCGTCTGCCAGACCATCCTTTTCTTTCCGCCATTCTAATGTCTTCAACCGATTCAATGCAATCACAGAAGTTTCACCAGTTTGAGCTCTTCCATCCATTACT
AACATCGGAGCATAGCAATCGGAAGCAACGAATCCGCATGGTTACTATTCCAGAGACGTCTCAAGATATCGTTCTCAAAGCTATCTTCGGACGCTCTCTTGTCCTCTATG
GAAGGTTACAAATAAGTCTAACAAGAGCTGATGATGAGAGATTTTTTGTAGAACAGCTACTTGATGTACTTTATAAGGATCTAGATCAAAGCAGCATCTCTAGTGTTGGG
GTTCCTTGGTCTGATACAAATAAAGATGATAAATTTGGAACTTTGAGTAGCTCACATTGTGGGTTGGTAGAACTTGCCGCAGCTGTACTCTATCGGGCATGTGTTACCTC
TACAAAAGCAATATCAACTGAAAAGCGGGTTAAAAGGGACCCAGCTAGTGTTCATCTTAAAGAGGAGCTTGCTAAAGGGAAATGGCTATGGAATGCGGCCTTCTGTTGTC
TTGTCAGAAATTACCATTCCCGCATCAGTAAGGATCTTTTCACCTACTGGTTTGAGGCAATTTGCTCAGGTTTCGAGAGAATATTGAAAGATGCAAATGTGGGACATTCA
TATGATGGATTGTTGTGGACATTACGGAGTCTGCAAGAACTTTCTTCAGTGTTAATAGATTCTACTGAACGGTCAGAAAGCTCGTCCGAGGAAAAGGTATGTTCCTCTTT
TCATTGTATTCTTATTCTTTTGTTTTTGTTTTTGTTTTGTATGGGAAAGCAAAAGAAGTGCCAAGCTAAAAGAGGGGATTGA

mRNA sequence

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Protein sequence

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MPFRLPDHPFLSAILMSSTDSMQSQKFHQFELFHPLLTSEHSNRKQRIRMVTIPETSQDIVLKAIFGRSLVLYGRLQISLTRADDERFFVEQLLDVLYKDLDQSSISSVG
VPWSDTNKDDKFGTLSSSHCGLVELAAAVLYRACVTSTKAISTEKRVKRDPASVHLKEELAKGKWLWNAAFCCLVRNYHSRISKDLFTYWFEAICSGFERILKDANVGHS
YDGLLWTLRSLQELSSVLIDSTERSESSSEEKVCSSFHCILILLFLFLFCMGKQKKCQAKRGD

Carg20228 (gene) of Silver-seed gourd (SMH-JMG-627) v2 genome