; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; CuGenDBv2

Chy11G198760 (gene) of Cucumber (hystrix) v1 genome

Gene IDChy11G198760
OrganismCucumis hystrix (Cucumber (hystrix) v1)
DescriptionDDB1- and CUL4-associated factor 8
Genome locationchrH11:19192485..19195368
RNA-Seq ExpressionChy11G198760
SyntenyChy11G198760
Gene Ontology termsGO:0005737 - cytoplasm (cellular component)
GO:0080008 - Cul4-RING E3 ubiquitin ligase complex (cellular component)
GO:0005515 - protein binding (molecular function)
InterPro domainsIPR001680 - WD40 repeat
IPR015943 - WD40/YVTN repeat-like-containing domain superfamily
IPR036322 - WD40-repeat-containing domain superfamily
IPR045151 - DDB1- and CUL4-associated factor 8-like


Homology Show/hide homology
GenBank top hitse value%identityAlignment
KAA0035289.1 DDB1- and CUL4-associated factor 8 isoform X1 [Cucumis melo var. makuwa]0.086.42Show/hide
Query:  MNPCYQGMNSDFAEICNRQIGIVPSTNFSRRFIASEII-------------------------------------------VKQLNLEHKLNGHDGCVNA
        MN CYQGMNSDFAEICNR+IGIVPS NFSRRFIASE++                                           VKQLNLEHKLNGH+GCVNA
Subjt:  MNPCYQGMNSDFAEICNRQIGIVPSTNFSRRFIASEII-------------------------------------------VKQLNLEHKLNGHDGCVNA

Query:  VEFNSTGDLLVSGSDDCKVILWDWARNSKRFSYPSGHLDNIFQTKIMPFTDDQKIVTSAADGKVRLGQVLGDGRVITQMLGEHQGSVHELAVEPGSPHIF
        VEFNSTGDLLVSGSDDCKVILWDWA NSKRFSYPSGHLDNIFQTKIMPFTDDQKIVTSAADGKVRLGQVLGDGRVITQMLGEHQGSVHELAVEPGSPHIF
Subjt:  VEFNSTGDLLVSGSDDCKVILWDWARNSKRFSYPSGHLDNIFQTKIMPFTDDQKIVTSAADGKVRLGQVLGDGRVITQMLGEHQGSVHELAVEPGSPHIF

Query:  YSCGEDGLVQHFDLRNTSARKLFYCTAFAERSRHPPNSIELNAIAIDPRNPNFFALGGSDEYARLYDLRNCRGDVTSSNRVVDTFCPHHLTQTNNFHITG
        YSCGEDGLVQHFDLRNTSARKLFYCT FAERS+HPP ++ELNAIAIDPRNPN FALGGSDEYARLYDLRNCRGDVTSSNRVVDTFCPHHL QTNNFHITG
Subjt:  YSCGEDGLVQHFDLRNTSARKLFYCTAFAERSRHPPNSIELNAIAIDPRNPNFFALGGSDEYARLYDLRNCRGDVTSSNRVVDTFCPHHLTQTNNFHITG

Query:  LAFSNSSELLITYSDELIYLFQKNMGLGPSPLTVSSENLLRELKRPQVFSGHRNSATVKGVNFFGPNAEYIVSGSDCGHIYIWKKKGALLVKLMLGDHDV
        LAFSNSSELLITYSDELIYLFQKNMGLGPSPLTVSSENLLRELKRPQV+SGHRNSATVKGVNFFGPNAEYIVSGSDCGHIYIWKKKGA+LVKLM GDHDV
Subjt:  LAFSNSSELLITYSDELIYLFQKNMGLGPSPLTVSSENLLRELKRPQVFSGHRNSATVKGVNFFGPNAEYIVSGSDCGHIYIWKKKGALLVKLMLGDHDV

Query:  VNHIEPHPHLPILATCGIENNVKIWTPMATDVPPLPDAMEQIMESNKQGREEHSRVTLTPDVIVHVLRLQRRQTSAFTERRYNPADINSDGENEWEAYNQ
        VNHIEPHPHLPILATCGIENN+KIWTPMA+DVPPLPD MEQIMESNKQGRE+HSRVTLTPDVIVH LRLQRRQTS FTERRYNPADINSD ENEWEAYN 
Subjt:  VNHIEPHPHLPILATCGIENNVKIWTPMATDVPPLPDAMEQIMESNKQGREEHSRVTLTPDVIVHVLRLQRRQTSAFTERRYNPADINSDGENEWEAYNQ

Query:  EALDGNVSFEDDSTEHASECNIS
        E LDGNVS E+DSTEHASECNIS
Subjt:  EALDGNVSFEDDSTEHASECNIS

XP_004149538.1 DDB1- and CUL4-associated factor 8 isoform X1 [Cucumis sativus]0.098.33Show/hide
Query:  MNPCYQGMNSDFAEICNRQIGIVPSTNFSRRFIASEIIVKQLNLEHKLNGHDGCVNAVEFNSTGDLLVSGSDDCKVILWDWARNSKRFSYPSGHLDNIFQ
        MN CY+GMNSDFAEICNRQIGIVPSTNFSRRFIASEIIVKQLNLEHKLNGHDGCVNAVEFNSTGDLLVSGSDDCKVILWDWARNSKRFSYPSGHLDNIFQ
Subjt:  MNPCYQGMNSDFAEICNRQIGIVPSTNFSRRFIASEIIVKQLNLEHKLNGHDGCVNAVEFNSTGDLLVSGSDDCKVILWDWARNSKRFSYPSGHLDNIFQ

Query:  TKIMPFTDDQKIVTSAADGKVRLGQVLGDGRVITQMLGEHQGSVHELAVEPGSPHIFYSCGEDGLVQHFDLRNTSARKLFYCTAFAERSRHPPNSIELNA
        TKIMPFTDDQKIVTSAADGKVRLGQVLGDGRVITQMLGEHQGSVHELAVEPGSPHIFYSCGEDGLVQHFDLRNTSARKLFYCTAFAERSRHPPNSIELNA
Subjt:  TKIMPFTDDQKIVTSAADGKVRLGQVLGDGRVITQMLGEHQGSVHELAVEPGSPHIFYSCGEDGLVQHFDLRNTSARKLFYCTAFAERSRHPPNSIELNA

Query:  IAIDPRNPNFFALGGSDEYARLYDLRNCRGDVTSSNRVVDTFCPHHLTQTNNFHITGLAFSNSSELLITYSDELIYLFQKNMGLGPSPLTVSSENLLREL
        IAIDPRNPNFFALGGSDEYARLYDLRNCRGDVTSSNRVVDTFCPHHLTQTNNFHITGL FSNSSELLITYSDELIYLFQKNMGLGPSPLTVSSENLLREL
Subjt:  IAIDPRNPNFFALGGSDEYARLYDLRNCRGDVTSSNRVVDTFCPHHLTQTNNFHITGLAFSNSSELLITYSDELIYLFQKNMGLGPSPLTVSSENLLREL

Query:  KRPQVFSGHRNSATVKGVNFFGPNAEYIVSGSDCGHIYIWKKKGALLVKLMLGDHDVVNHIEPHPHLPILATCGIENNVKIWTPMATDVPPLPDAMEQIM
        KRP VFSGHRNSATVKGVNFFGPNAEYIVSGSDCGHIYIWKKKGALLVKLMLGDHDVVNHIEPHPHLPILATCGIENNVKIWTPMA+DVPPLPD MEQIM
Subjt:  KRPQVFSGHRNSATVKGVNFFGPNAEYIVSGSDCGHIYIWKKKGALLVKLMLGDHDVVNHIEPHPHLPILATCGIENNVKIWTPMATDVPPLPDAMEQIM

Query:  ESNKQGREEHSRVTLTPDVIVHVLRLQRRQTSAFTERRYNPADINSDGENEWEAYNQEALDGNVSFEDDSTEHASECNIS
        ESNKQGREEHSRVTLTPDVIVHVLRLQRRQTSAFTERRYNPAD NSDGENEWEAYNQEALDG+VSFEDDSTEHASECNIS
Subjt:  ESNKQGREEHSRVTLTPDVIVHVLRLQRRQTSAFTERRYNPADINSDGENEWEAYNQEALDGNVSFEDDSTEHASECNIS

XP_008463886.1 PREDICTED: DDB1- and CUL4-associated factor 8 isoform X1 [Cucumis melo]0.094.17Show/hide
Query:  MNPCYQGMNSDFAEICNRQIGIVPSTNFSRRFIASEIIVKQLNLEHKLNGHDGCVNAVEFNSTGDLLVSGSDDCKVILWDWARNSKRFSYPSGHLDNIFQ
        MN CYQGMNSDFAEICNR+IGIVPS NFSRRFIASE  VKQLNLEHKLNGH+GCVNAVEFNSTGDLLVSGSDDCKVILWDWA NSKRFSYPSGHLDNIFQ
Subjt:  MNPCYQGMNSDFAEICNRQIGIVPSTNFSRRFIASEIIVKQLNLEHKLNGHDGCVNAVEFNSTGDLLVSGSDDCKVILWDWARNSKRFSYPSGHLDNIFQ

Query:  TKIMPFTDDQKIVTSAADGKVRLGQVLGDGRVITQMLGEHQGSVHELAVEPGSPHIFYSCGEDGLVQHFDLRNTSARKLFYCTAFAERSRHPPNSIELNA
        TKIMPFTDDQKIVTSAADGKVRLGQVLGDGRVITQMLGEHQGSVHELAVEPGSPHIFYSCGEDGLVQHFDLRNTSARKLFYCT FAERS+HPP ++ELNA
Subjt:  TKIMPFTDDQKIVTSAADGKVRLGQVLGDGRVITQMLGEHQGSVHELAVEPGSPHIFYSCGEDGLVQHFDLRNTSARKLFYCTAFAERSRHPPNSIELNA

Query:  IAIDPRNPNFFALGGSDEYARLYDLRNCRGDVTSSNRVVDTFCPHHLTQTNNFHITGLAFSNSSELLITYSDELIYLFQKNMGLGPSPLTVSSENLLREL
        IAIDPRNPN FALGGSDEYARLYDLRNCRGDVTSSNRVVDTFCPHHL QTNNFHITGLAFSNSSELLITYSDELIYLFQKNMGLGPSPLTVSSENLLREL
Subjt:  IAIDPRNPNFFALGGSDEYARLYDLRNCRGDVTSSNRVVDTFCPHHLTQTNNFHITGLAFSNSSELLITYSDELIYLFQKNMGLGPSPLTVSSENLLREL

Query:  KRPQVFSGHRNSATVKGVNFFGPNAEYIVSGSDCGHIYIWKKKGALLVKLMLGDHDVVNHIEPHPHLPILATCGIENNVKIWTPMATDVPPLPDAMEQIM
        KRPQV+SGHRNSATVKGVNFFGPNAEYIVSGSDCGHIYIWKKKGA+LVKLM GDHDVVNHIEPHPHLPILATCGIENN+KIWTPMA+DVPPLPD MEQIM
Subjt:  KRPQVFSGHRNSATVKGVNFFGPNAEYIVSGSDCGHIYIWKKKGALLVKLMLGDHDVVNHIEPHPHLPILATCGIENNVKIWTPMATDVPPLPDAMEQIM

Query:  ESNKQGREEHSRVTLTPDVIVHVLRLQRRQTSAFTERRYNPADINSDGENEWEAYNQEALDGNVSFEDDSTEHASECNIS
        ESNKQGRE+HSRVTLTPDVIVH LRLQRRQTS FTERRYNPADINSD ENEWEAYN E LDGNVS E+DSTEHASECNIS
Subjt:  ESNKQGREEHSRVTLTPDVIVHVLRLQRRQTSAFTERRYNPADINSDGENEWEAYNQEALDGNVSFEDDSTEHASECNIS

XP_038902691.1 DDB1- and CUL4-associated factor 8 isoform X1 [Benincasa hispida]0.087.73Show/hide
Query:  MNPCYQGMNSDFAEICNRQIGIVPSTNFSRRFIASEIIVKQLNLEHKLNGHDGCVNAVEFNSTGDLLVSGSDDCKVILWDWARNSKRFSYPSGHLDNIFQ
        MN CY+G N +  EICNR+IGI  S NFSRRF ASEIIVKQLNLE KLNGHDGCVNAVEFNSTGDLLVSGSDDCKVILWDWARNS+RFSYPSGHLDNIFQ
Subjt:  MNPCYQGMNSDFAEICNRQIGIVPSTNFSRRFIASEIIVKQLNLEHKLNGHDGCVNAVEFNSTGDLLVSGSDDCKVILWDWARNSKRFSYPSGHLDNIFQ

Query:  TKIMPFTDDQKIVTSAADGKVRLGQVLGDGRVITQMLGEHQGSVHELAVEPGSPHIFYSCGEDGLVQHFDLRNTSARKLFYCTAFAERSRHPPNSIELNA
        TKIMPFTDDQKIVTSAADGKVRLGQVLGDGRVIT+MLGEHQG VHELAVEPGSPH+ YSCGEDGLVQHFDLRNTS RKLFYCT FAERS+ PP S+ELNA
Subjt:  TKIMPFTDDQKIVTSAADGKVRLGQVLGDGRVITQMLGEHQGSVHELAVEPGSPHIFYSCGEDGLVQHFDLRNTSARKLFYCTAFAERSRHPPNSIELNA

Query:  IAIDPRNPNFFALGGSDEYARLYDLRNCRGDV-TSSNRVVDTFCPHHLTQTNNFHITGLAFSNSSELLITYSDELIYLFQKNMGLGPSPLTVSSENLLRE
        I IDPRNPN+FALGGSDEYARLYDLRNCRGD  TSSNRV+DTFCPHHL QTNNFHITGLAFSNSSELL+TYSDELIYLFQKNMGLGPSPLTVSSENLLR+
Subjt:  IAIDPRNPNFFALGGSDEYARLYDLRNCRGDV-TSSNRVVDTFCPHHLTQTNNFHITGLAFSNSSELLITYSDELIYLFQKNMGLGPSPLTVSSENLLRE

Query:  LKRPQVFSGHRNSATVKGVNFFGPNAEYIVSGSDCGHIYIWKKKGALLVKLMLGDHDVVNHIEPHPHLPILATCGIENNVKIWTPMATDVPPLPDAMEQI
        LK+PQV++GHRNSATVKGVNFFGPNAEY+VSGSDCGHIYIWKKKGA LVKLM+GD +VVNHIEPHPHLPILATCGIENNVKIWTPM +DVPPLPD +E I
Subjt:  LKRPQVFSGHRNSATVKGVNFFGPNAEYIVSGSDCGHIYIWKKKGALLVKLMLGDHDVVNHIEPHPHLPILATCGIENNVKIWTPMATDVPPLPDAMEQI

Query:  MESNKQGREEHSRVTLTPDVIVHVLRLQRRQTSAFTERRYNPADINSDGENEWEAYNQEALDGNVSFEDDSTEHASECNIS
        MESN+QGRE+HSRVTLTPDVI+HVLRLQRRQ SAFTERRY+ ADI+SD ENEWE+YN + LDGNVSFE+DSTE+ASECNIS
Subjt:  MESNKQGREEHSRVTLTPDVIVHVLRLQRRQTSAFTERRYNPADINSDGENEWEAYNQEALDGNVSFEDDSTEHASECNIS

XP_038902693.1 DDB1- and CUL4-associated factor 8 isoform X2 [Benincasa hispida]1.24e-31286.07Show/hide
Query:  MNPCYQGMNSDFAEICNRQIGIVPSTNFSRRFIASEIIVKQLNLEHKLNGHDGCVNAVEFNSTGDLLVSGSDDCKVILWDWARNSKRFSYPSGHLDNIFQ
        MN CY+G N +  EICNR+IGI  S NFSRRF ASEIIVKQLNLE KLNGHDGCVNAVEFNSTGDLLVSGSDDCKVILWDWARNS+RFSYPSGHLDNIFQ
Subjt:  MNPCYQGMNSDFAEICNRQIGIVPSTNFSRRFIASEIIVKQLNLEHKLNGHDGCVNAVEFNSTGDLLVSGSDDCKVILWDWARNSKRFSYPSGHLDNIFQ

Query:  TKIMPFTDDQKIVTSAADGKVRLGQVLGDGRVITQMLGEHQGSVHELAVEPGSPHIFYSCGEDGLVQHFDLRNTSARKLFYCTAFAERSRHPPNSIELNA
        TKIMPFTDDQKIVTSAADGKVRLGQVLGDGRVIT+MLGEHQG VHELAVEPGSPH+ YSCGEDGLVQHFDLRNTS RKLFYCT FAERS+ PP S+ELNA
Subjt:  TKIMPFTDDQKIVTSAADGKVRLGQVLGDGRVITQMLGEHQGSVHELAVEPGSPHIFYSCGEDGLVQHFDLRNTSARKLFYCTAFAERSRHPPNSIELNA

Query:  IAIDPRNPNFFALGGSDEYARLYDLRNCRGDV-TSSNRVVDTFCPHHLTQTNNFHITGLAFSNSSELLITYSDELIYLFQKNMGLGPSPLTVSSENLLRE
        I IDPRNPN+FALGGSDEYARLYDLRNCRGD  TSSNRV+DTFCPHHL QTNNFHITGLAFSNSSELL+TYSDELIYLFQKNMGLGPSPLTVSSENLLR+
Subjt:  IAIDPRNPNFFALGGSDEYARLYDLRNCRGDV-TSSNRVVDTFCPHHLTQTNNFHITGLAFSNSSELLITYSDELIYLFQKNMGLGPSPLTVSSENLLRE

Query:  LKRPQVFSGHRNSATVKGVNFFGPNAEYIVSGSDCGHIYIWKKKGALLVKLMLGDHDVVNHIEPHPHLPILATCGIENNVKIWTPMATDVPPLPDAMEQI
        LK+PQV++GHRNSATVKGVNFFGPNAEY+VSGSDCGHIYIWKKKGA LVKLM+GD +VVNHIEPHPHLPILATCGIENNVKIWTPM             I
Subjt:  LKRPQVFSGHRNSATVKGVNFFGPNAEYIVSGSDCGHIYIWKKKGALLVKLMLGDHDVVNHIEPHPHLPILATCGIENNVKIWTPMATDVPPLPDAMEQI

Query:  MESNKQGREEHSRVTLTPDVIVHVLRLQRRQTSAFTERRYNPADINSDGENEWEAYNQEALDGNVSFEDDSTEHASECNIS
        MESN+QGRE+HSRVTLTPDVI+HVLRLQRRQ SAFTERRY+ ADI+SD ENEWE+YN + LDGNVSFE+DSTE+ASECNIS
Subjt:  MESNKQGREEHSRVTLTPDVIVHVLRLQRRQTSAFTERRYNPADINSDGENEWEAYNQEALDGNVSFEDDSTEHASECNIS

TrEMBL top hitse value%identityAlignment
A0A0A0KC69 Uncharacterized protein3.4e-28398.33Show/hide
Query:  MNPCYQGMNSDFAEICNRQIGIVPSTNFSRRFIASEIIVKQLNLEHKLNGHDGCVNAVEFNSTGDLLVSGSDDCKVILWDWARNSKRFSYPSGHLDNIFQ
        MN CY+GMNSDFAEICNRQIGIVPSTNFSRRFIASEIIVKQLNLEHKLNGHDGCVNAVEFNSTGDLLVSGSDDCKVILWDWARNSKRFSYPSGHLDNIFQ
Subjt:  MNPCYQGMNSDFAEICNRQIGIVPSTNFSRRFIASEIIVKQLNLEHKLNGHDGCVNAVEFNSTGDLLVSGSDDCKVILWDWARNSKRFSYPSGHLDNIFQ

Query:  TKIMPFTDDQKIVTSAADGKVRLGQVLGDGRVITQMLGEHQGSVHELAVEPGSPHIFYSCGEDGLVQHFDLRNTSARKLFYCTAFAERSRHPPNSIELNA
        TKIMPFTDDQKIVTSAADGKVRLGQVLGDGRVITQMLGEHQGSVHELAVEPGSPHIFYSCGEDGLVQHFDLRNTSARKLFYCTAFAERSRHPPNSIELNA
Subjt:  TKIMPFTDDQKIVTSAADGKVRLGQVLGDGRVITQMLGEHQGSVHELAVEPGSPHIFYSCGEDGLVQHFDLRNTSARKLFYCTAFAERSRHPPNSIELNA

Query:  IAIDPRNPNFFALGGSDEYARLYDLRNCRGDVTSSNRVVDTFCPHHLTQTNNFHITGLAFSNSSELLITYSDELIYLFQKNMGLGPSPLTVSSENLLREL
        IAIDPRNPNFFALGGSDEYARLYDLRNCRGDVTSSNRVVDTFCPHHLTQTNNFHITGL FSNSSELLITYSDELIYLFQKNMGLGPSPLTVSSENLLREL
Subjt:  IAIDPRNPNFFALGGSDEYARLYDLRNCRGDVTSSNRVVDTFCPHHLTQTNNFHITGLAFSNSSELLITYSDELIYLFQKNMGLGPSPLTVSSENLLREL

Query:  KRPQVFSGHRNSATVKGVNFFGPNAEYIVSGSDCGHIYIWKKKGALLVKLMLGDHDVVNHIEPHPHLPILATCGIENNVKIWTPMATDVPPLPDAMEQIM
        KRP VFSGHRNSATVKGVNFFGPNAEYIVSGSDCGHIYIWKKKGALLVKLMLGDHDVVNHIEPHPHLPILATCGIENNVKIWTPMA+DVPPLPD MEQIM
Subjt:  KRPQVFSGHRNSATVKGVNFFGPNAEYIVSGSDCGHIYIWKKKGALLVKLMLGDHDVVNHIEPHPHLPILATCGIENNVKIWTPMATDVPPLPDAMEQIM

Query:  ESNKQGREEHSRVTLTPDVIVHVLRLQRRQTSAFTERRYNPADINSDGENEWEAYNQEALDGNVSFEDDSTEHASECNIS
        ESNKQGREEHSRVTLTPDVIVHVLRLQRRQTSAFTERRYNPAD NSDGENEWEAYNQEALDG+VSFEDDSTEHASECNIS
Subjt:  ESNKQGREEHSRVTLTPDVIVHVLRLQRRQTSAFTERRYNPADINSDGENEWEAYNQEALDGNVSFEDDSTEHASECNIS

A0A1S3CLR9 DDB1- and CUL4-associated factor 8 isoform X17.0e-27394.17Show/hide
Query:  MNPCYQGMNSDFAEICNRQIGIVPSTNFSRRFIASEIIVKQLNLEHKLNGHDGCVNAVEFNSTGDLLVSGSDDCKVILWDWARNSKRFSYPSGHLDNIFQ
        MN CYQGMNSDFAEICNR+IGIVPS NFSRRFIASE  VKQLNLEHKLNGH+GCVNAVEFNSTGDLLVSGSDDCKVILWDWA NSKRFSYPSGHLDNIFQ
Subjt:  MNPCYQGMNSDFAEICNRQIGIVPSTNFSRRFIASEIIVKQLNLEHKLNGHDGCVNAVEFNSTGDLLVSGSDDCKVILWDWARNSKRFSYPSGHLDNIFQ

Query:  TKIMPFTDDQKIVTSAADGKVRLGQVLGDGRVITQMLGEHQGSVHELAVEPGSPHIFYSCGEDGLVQHFDLRNTSARKLFYCTAFAERSRHPPNSIELNA
        TKIMPFTDDQKIVTSAADGKVRLGQVLGDGRVITQMLGEHQGSVHELAVEPGSPHIFYSCGEDGLVQHFDLRNTSARKLFYCT FAERS+HPP ++ELNA
Subjt:  TKIMPFTDDQKIVTSAADGKVRLGQVLGDGRVITQMLGEHQGSVHELAVEPGSPHIFYSCGEDGLVQHFDLRNTSARKLFYCTAFAERSRHPPNSIELNA

Query:  IAIDPRNPNFFALGGSDEYARLYDLRNCRGDVTSSNRVVDTFCPHHLTQTNNFHITGLAFSNSSELLITYSDELIYLFQKNMGLGPSPLTVSSENLLREL
        IAIDPRNPN FALGGSDEYARLYDLRNCRGDVTSSNRVVDTFCPHHL QTNNFHITGLAFSNSSELLITYSDELIYLFQKNMGLGPSPLTVSSENLLREL
Subjt:  IAIDPRNPNFFALGGSDEYARLYDLRNCRGDVTSSNRVVDTFCPHHLTQTNNFHITGLAFSNSSELLITYSDELIYLFQKNMGLGPSPLTVSSENLLREL

Query:  KRPQVFSGHRNSATVKGVNFFGPNAEYIVSGSDCGHIYIWKKKGALLVKLMLGDHDVVNHIEPHPHLPILATCGIENNVKIWTPMATDVPPLPDAMEQIM
        KRPQV+SGHRNSATVKGVNFFGPNAEYIVSGSDCGHIYIWKKKGA+LVKLM GDHDVVNHIEPHPHLPILATCGIENN+KIWTPMA+DVPPLPD MEQIM
Subjt:  KRPQVFSGHRNSATVKGVNFFGPNAEYIVSGSDCGHIYIWKKKGALLVKLMLGDHDVVNHIEPHPHLPILATCGIENNVKIWTPMATDVPPLPDAMEQIM

Query:  ESNKQGREEHSRVTLTPDVIVHVLRLQRRQTSAFTERRYNPADINSDGENEWEAYNQEALDGNVSFEDDSTEHASECNIS
        ESNKQGRE+HSRVTLTPDVIVH LRLQRRQTS FTERRYNPADINSD ENEWEAYN E LDGNVS E+DSTEHASECNIS
Subjt:  ESNKQGREEHSRVTLTPDVIVHVLRLQRRQTSAFTERRYNPADINSDGENEWEAYNQEALDGNVSFEDDSTEHASECNIS

A0A5A7T1Q2 DDB1-and CUL4-associated factor 8 isoform X11.2e-26786.42Show/hide
Query:  MNPCYQGMNSDFAEICNRQIGIVPSTNFSRRFIASEII-------------------------------------------VKQLNLEHKLNGHDGCVNA
        MN CYQGMNSDFAEICNR+IGIVPS NFSRRFIASE++                                           VKQLNLEHKLNGH+GCVNA
Subjt:  MNPCYQGMNSDFAEICNRQIGIVPSTNFSRRFIASEII-------------------------------------------VKQLNLEHKLNGHDGCVNA

Query:  VEFNSTGDLLVSGSDDCKVILWDWARNSKRFSYPSGHLDNIFQTKIMPFTDDQKIVTSAADGKVRLGQVLGDGRVITQMLGEHQGSVHELAVEPGSPHIF
        VEFNSTGDLLVSGSDDCKVILWDWA NSKRFSYPSGHLDNIFQTKIMPFTDDQKIVTSAADGKVRLGQVLGDGRVITQMLGEHQGSVHELAVEPGSPHIF
Subjt:  VEFNSTGDLLVSGSDDCKVILWDWARNSKRFSYPSGHLDNIFQTKIMPFTDDQKIVTSAADGKVRLGQVLGDGRVITQMLGEHQGSVHELAVEPGSPHIF

Query:  YSCGEDGLVQHFDLRNTSARKLFYCTAFAERSRHPPNSIELNAIAIDPRNPNFFALGGSDEYARLYDLRNCRGDVTSSNRVVDTFCPHHLTQTNNFHITG
        YSCGEDGLVQHFDLRNTSARKLFYCT FAERS+HPP ++ELNAIAIDPRNPN FALGGSDEYARLYDLRNCRGDVTSSNRVVDTFCPHHL QTNNFHITG
Subjt:  YSCGEDGLVQHFDLRNTSARKLFYCTAFAERSRHPPNSIELNAIAIDPRNPNFFALGGSDEYARLYDLRNCRGDVTSSNRVVDTFCPHHLTQTNNFHITG

Query:  LAFSNSSELLITYSDELIYLFQKNMGLGPSPLTVSSENLLRELKRPQVFSGHRNSATVKGVNFFGPNAEYIVSGSDCGHIYIWKKKGALLVKLMLGDHDV
        LAFSNSSELLITYSDELIYLFQKNMGLGPSPLTVSSENLLRELKRPQV+SGHRNSATVKGVNFFGPNAEYIVSGSDCGHIYIWKKKGA+LVKLM GDHDV
Subjt:  LAFSNSSELLITYSDELIYLFQKNMGLGPSPLTVSSENLLRELKRPQVFSGHRNSATVKGVNFFGPNAEYIVSGSDCGHIYIWKKKGALLVKLMLGDHDV

Query:  VNHIEPHPHLPILATCGIENNVKIWTPMATDVPPLPDAMEQIMESNKQGREEHSRVTLTPDVIVHVLRLQRRQTSAFTERRYNPADINSDGENEWEAYNQ
        VNHIEPHPHLPILATCGIENN+KIWTPMA+DVPPLPD MEQIMESNKQGRE+HSRVTLTPDVIVH LRLQRRQTS FTERRYNPADINSD ENEWEAYN 
Subjt:  VNHIEPHPHLPILATCGIENNVKIWTPMATDVPPLPDAMEQIMESNKQGREEHSRVTLTPDVIVHVLRLQRRQTSAFTERRYNPADINSDGENEWEAYNQ

Query:  EALDGNVSFEDDSTEHASECNIS
        E LDGNVS E+DSTEHASECNIS
Subjt:  EALDGNVSFEDDSTEHASECNIS

A0A6J1FWZ1 DDB1- and CUL4-associated factor 81.2e-24585.03Show/hide
Query:  MNPCYQGMNSDFAEICNRQIGIVPSTNFSRRFIASEIIVKQLNLEHKLNGHDGCVNAVEFNSTGDLLVSGSDDCKVILWDWARNSKRFSYPSGHLDNIFQ
        MN CY GM+ + AEIC+R+IG   S NFSRRF ASEIIVKQLNLE KLNGHDGCVNAVEFNSTGDLLVSGSDDCKVILWDWARNS+RFSYPSGHLDNIFQ
Subjt:  MNPCYQGMNSDFAEICNRQIGIVPSTNFSRRFIASEIIVKQLNLEHKLNGHDGCVNAVEFNSTGDLLVSGSDDCKVILWDWARNSKRFSYPSGHLDNIFQ

Query:  TKIMPFTDDQKIVTSAADGKVRLGQVLGDGRVITQMLGEHQGSVHELAVEPGSPHIFYSCGEDGLVQHFDLRNTSARKLFYCTAFAERSRHPPNSIELNA
        TKIMPFT+DQKIVTSAADGKVRLGQVL DGRV+ +MLGEHQGSVHELAVEPGSPHI YSCGEDGLVQHFDLRN+SA KLFYCT+FAERS+ PP  + LNA
Subjt:  TKIMPFTDDQKIVTSAADGKVRLGQVLGDGRVITQMLGEHQGSVHELAVEPGSPHIFYSCGEDGLVQHFDLRNTSARKLFYCTAFAERSRHPPNSIELNA

Query:  IAIDPRNPNFFALGGSDEYARLYDLRNCRGDV-TSSNRVVDTFCPHHLTQTNNFHITGLAFSNSSELLITYSDELIYLFQKNMGLGPSPLTVSSENLLRE
        I  DPRNPN+FALGGSDEYARLYDLRNC G   ++SNRV+DTFCPHHL QTNNFHITGLAFSNSSELL+TYSDELIYLFQKNMGLGPSPLTVSSENLLR+
Subjt:  IAIDPRNPNFFALGGSDEYARLYDLRNCRGDV-TSSNRVVDTFCPHHLTQTNNFHITGLAFSNSSELLITYSDELIYLFQKNMGLGPSPLTVSSENLLRE

Query:  LKRPQVFSGHRNSATVKGVNFFGPNAEYIVSGSDCGHIYIWKKKGALLVKLMLGDHDVVNHIEPHPHLPILATCGIENNVKIWTPMATDVPPLPDAMEQI
        LKRPQV+SGHRNSATVKGVNFFG N+EY+VSGSDCGHIYIWKKKGA+LVKLM+GD +VVNHIEPHPHLPILATCGIE NVKIWTPMA DVPPLPD +EQI
Subjt:  LKRPQVFSGHRNSATVKGVNFFGPNAEYIVSGSDCGHIYIWKKKGALLVKLMLGDHDVVNHIEPHPHLPILATCGIENNVKIWTPMATDVPPLPDAMEQI

Query:  MESNKQGREEHSRVTLTPDVIVHVLRLQRRQTSAFTERRYNPADINSDGENEWEAYNQEALDGNVSFEDDSTEHASECNIS
        MESN+QGRE+HSRVTLTPDVI+HVLRLQRRQ SAFTERRY+  DI SD +NEWEA N E LDGNVSFE+DSTE++S+CNIS
Subjt:  MESNKQGREEHSRVTLTPDVIVHVLRLQRRQTSAFTERRYNPADINSDGENEWEAYNQEALDGNVSFEDDSTEHASECNIS

A0A6J1JA63 DDB1- and CUL4-associated factor 86.6e-24785.24Show/hide
Query:  MNPCYQGMNSDFAEICNRQIGIVPSTNFSRRFIASEIIVKQLNLEHKLNGHDGCVNAVEFNSTGDLLVSGSDDCKVILWDWARNSKRFSYPSGHLDNIFQ
        MN CY GM+ + AEIC+R+IGI  S NFSRRF ASEIIVKQLNLE KLNGHDGCVNAVEFNSTGDLLVSGSDDCKVILWDWARNS+RFSYPSGHLDNIFQ
Subjt:  MNPCYQGMNSDFAEICNRQIGIVPSTNFSRRFIASEIIVKQLNLEHKLNGHDGCVNAVEFNSTGDLLVSGSDDCKVILWDWARNSKRFSYPSGHLDNIFQ

Query:  TKIMPFTDDQKIVTSAADGKVRLGQVLGDGRVITQMLGEHQGSVHELAVEPGSPHIFYSCGEDGLVQHFDLRNTSARKLFYCTAFAERSRHPPNSIELNA
        TKIMPFT+D+KIVTSAADGKVRLG+VL DGRV+ +MLGEHQGSVHELAVEPGSPHI YSCGEDGLVQHFDLRN+SA KLFYCT+FAERS+ PP  + LNA
Subjt:  TKIMPFTDDQKIVTSAADGKVRLGQVLGDGRVITQMLGEHQGSVHELAVEPGSPHIFYSCGEDGLVQHFDLRNTSARKLFYCTAFAERSRHPPNSIELNA

Query:  IAIDPRNPNFFALGGSDEYARLYDLRNCRGDV-TSSNRVVDTFCPHHLTQTNNFHITGLAFSNSSELLITYSDELIYLFQKNMGLGPSPLTVSSENLLRE
        I  DPRNPN+FALGGSDEYARLYDLRNC G   ++SNRV+DTFCPHHL QTNNFHITGLAFSNSSELL+TYSDELIYLFQKNMGLGPSPLTVSSENLLR+
Subjt:  IAIDPRNPNFFALGGSDEYARLYDLRNCRGDV-TSSNRVVDTFCPHHLTQTNNFHITGLAFSNSSELLITYSDELIYLFQKNMGLGPSPLTVSSENLLRE

Query:  LKRPQVFSGHRNSATVKGVNFFGPNAEYIVSGSDCGHIYIWKKKGALLVKLMLGDHDVVNHIEPHPHLPILATCGIENNVKIWTPMATDVPPLPDAMEQI
        LKRPQV+SGHRNSATVKGVNFFGPN+EY+VSGSDCGHIYIWKKKGA+LVKLM+GD +VVNHIEPHPHLPILATCGIE NVKIWTPMA DVPPLPD +EQI
Subjt:  LKRPQVFSGHRNSATVKGVNFFGPNAEYIVSGSDCGHIYIWKKKGALLVKLMLGDHDVVNHIEPHPHLPILATCGIENNVKIWTPMATDVPPLPDAMEQI

Query:  MESNKQGREEHSRVTLTPDVIVHVLRLQRRQTSAFTERRYNPADINSDGENEWEAYNQEALDGNVSFEDDSTEHASECNIS
        MESN+QGRE+HSRVTLTPDVI+HVLRLQRRQ SAFTERRY+  DI SD ENEWEA N E LDGNVSFE+DSTE++S+CNIS
Subjt:  MESNKQGREEHSRVTLTPDVIVHVLRLQRRQTSAFTERRYNPADINSDGENEWEAYNQEALDGNVSFEDDSTEHASECNIS

SwissProt top hitse value%identityAlignment
Q5R448 DDB1- and CUL4-associated factor 81.6e-8038.64Show/hide
Query:  RQIGIVPSTNFSRRFIASEIIVKQLNLEHKLNGHDGCVNAVEFNSTGDLLVSGSDDCKVILWDWARNSKRFSYPSGHLDNIFQTKIMPFTDDQKIVTSAA
        R++G   S  F      + + V++  L+H L GH GCVN + FN  G  L SGSDD KV++WDW R      + SGH  N+FQ K +P + D  +   A 
Subjt:  RQIGIVPSTNFSRRFIASEIIVKQLNLEHKLNGHDGCVNAVEFNSTGDLLVSGSDDCKVILWDWARNSKRFSYPSGHLDNIFQTKIMPFTDDQKIVTSAA

Query:  DGKVRLGQVLGDGRV-ITQMLGEHQGSVHELAVEPGSPHIFYSCGEDGLVQHFDLRNTSARKLFYCTAFAERSRHPPNSIELNAIAIDPRNPNFFALGGS
        DG+VR+ ++        T+ + +H+G+ H+LA+EP SP  F S GED +V   DLR          T   E+       + L  I ++P N + FA+GG 
Subjt:  DGKVRLGQVLGDGRV-ITQMLGEHQGSVHELAVEPGSPHIFYSCGEDGLVQHFDLRNTSARKLFYCTAFAERSRHPPNSIELNAIAIDPRNPNFFALGGS

Query:  DEYARLYDLRNCRGDVTSSNRVVDTFCPHHLTQ-TNNFHITGLAFS-NSSELLITYSDELIYLFQKNMGLGPSPLTVSSENLLRELKRPQVFSGHRNSAT
        D++ R+YD R    D   +N V+  FCPHHL    +  +IT L +S + +ELL +Y+DE IYLF  +   G            + +KR   + GHRN+AT
Subjt:  DEYARLYDLRNCRGDVTSSNRVVDTFCPHHLTQ-TNNFHITGLAFS-NSSELLITYSDELIYLFQKNMGLGPSPLTVSSENLLRELKRPQVFSGHRNSAT

Query:  VKGVNFFGPNAEYIVSGSDCGHIYIWKKKGALLVKLMLGDH-DVVNHIEPHPHLPILATCGIENNVKIWTPMATDVPPLPDAMEQIMESNKQGREEHS--
        VKGVNF+GP +E++VSGSDCGHI++W+K    +++ M GD   VVN +EPHPHLP+LAT G++++VKIW P A     L   ++ +++ NK+ R+E S  
Subjt:  VKGVNFFGPNAEYIVSGSDCGHIYIWKKKGALLVKLMLGDH-DVVNHIEPHPHLPILATCGIENNVKIWTPMATDVPPLPDAMEQIMESNKQGREEHS--

Query:  RVTLTPD----VIVHVLRLQRRQTSAFTERRYNPADINSD
        R  L        ++H LR QRR    + E      D +SD
Subjt:  RVTLTPD----VIVHVLRLQRRQTSAFTERRYNPADINSD

Q5TAQ9 DDB1- and CUL4-associated factor 82.7e-8038.41Show/hide
Query:  RQIGIVPSTNFSRRFIASEIIVKQLNLEHKLNGHDGCVNAVEFNSTGDLLVSGSDDCKVILWDWARNSKRFSYPSGHLDNIFQTKIMPFTDDQKIVTSAA
        R++G   S  F      + + V++  L+H L GH GCVN + FN  G  L SGSDD KV++WDW R      + SGH  N+FQ K +P + D  +   A 
Subjt:  RQIGIVPSTNFSRRFIASEIIVKQLNLEHKLNGHDGCVNAVEFNSTGDLLVSGSDDCKVILWDWARNSKRFSYPSGHLDNIFQTKIMPFTDDQKIVTSAA

Query:  DGKVRLGQVLGDGRV-ITQMLGEHQGSVHELAVEPGSPHIFYSCGEDGLVQHFDLRNTSARKLFYCTAFAERSRHPPNSIELNAIAIDPRNPNFFALGGS
        DG+VR+ ++        T+ + +H+G+ H+LA+EP SP  F S GED +V   DLR          T   E+       + L  I ++P N + FA+GG 
Subjt:  DGKVRLGQVLGDGRV-ITQMLGEHQGSVHELAVEPGSPHIFYSCGEDGLVQHFDLRNTSARKLFYCTAFAERSRHPPNSIELNAIAIDPRNPNFFALGGS

Query:  DEYARLYDLRNCRGDVTSSNRVVDTFCPHHLTQT-NNFHITGLAFS-NSSELLITYSDELIYLFQKNMGLGPSPLTVSSENLLRELKRPQVFSGHRNSAT
        D++ R+YD R    D   +N V+  FCPHHL  + +  +IT L +S + +ELL +Y+DE IYLF  +   G            + +KR   + GHRN+AT
Subjt:  DEYARLYDLRNCRGDVTSSNRVVDTFCPHHLTQT-NNFHITGLAFS-NSSELLITYSDELIYLFQKNMGLGPSPLTVSSENLLRELKRPQVFSGHRNSAT

Query:  VKGVNFFGPNAEYIVSGSDCGHIYIWKKKGALLVKLMLGDH-DVVNHIEPHPHLPILATCGIENNVKIWTPMATDVPPLPDAMEQIMESNKQGREEHS--
        VKGVNF+GP +E++VSGSDCGHI++W+K    +++ M GD   VVN +EPHPHLP+LAT G++++VKIW P A     L   ++ +++ NK+ R+E S  
Subjt:  VKGVNFFGPNAEYIVSGSDCGHIYIWKKKGALLVKLMLGDH-DVVNHIEPHPHLPILATCGIENNVKIWTPMATDVPPLPDAMEQIMESNKQGREEHS--

Query:  RVTLTPD----VIVHVLRLQRRQTSAFTERRYNPADINSD
        +  L        ++H LR QRR    + E      D +SD
Subjt:  RVTLTPD----VIVHVLRLQRRQTSAFTERRYNPADINSD

Q5U2M6 DDB1- and CUL4-associated factor 82.7e-8038.41Show/hide
Query:  RQIGIVPSTNFSRRFIASEIIVKQLNLEHKLNGHDGCVNAVEFNSTGDLLVSGSDDCKVILWDWARNSKRFSYPSGHLDNIFQTKIMPFTDDQKIVTSAA
        R++G   S  F      + + V++  L+H L GH GCVN + FN  G  L SGSDD KV++WDW R      + SGH  N+FQ K +P + D  +   A 
Subjt:  RQIGIVPSTNFSRRFIASEIIVKQLNLEHKLNGHDGCVNAVEFNSTGDLLVSGSDDCKVILWDWARNSKRFSYPSGHLDNIFQTKIMPFTDDQKIVTSAA

Query:  DGKVRLGQVLGDGRV-ITQMLGEHQGSVHELAVEPGSPHIFYSCGEDGLVQHFDLRNTSARKLFYCTAFAERSRHPPNSIELNAIAIDPRNPNFFALGGS
        DG+VR+ ++        T+ + +H+G+ H+LA+EP SP  F S GED +V   DLR          T   E+       + L  I ++P N + FA+GG 
Subjt:  DGKVRLGQVLGDGRV-ITQMLGEHQGSVHELAVEPGSPHIFYSCGEDGLVQHFDLRNTSARKLFYCTAFAERSRHPPNSIELNAIAIDPRNPNFFALGGS

Query:  DEYARLYDLRNCRGDVTSSNRVVDTFCPHHLTQT-NNFHITGLAFS-NSSELLITYSDELIYLFQKNMGLGPSPLTVSSENLLRELKRPQVFSGHRNSAT
        D++ R+YD R    D   +N V+  FCPHHL  + +  +IT L +S + +ELL +Y+DE IYLF  +   G            + +KR   + GHRN+AT
Subjt:  DEYARLYDLRNCRGDVTSSNRVVDTFCPHHLTQT-NNFHITGLAFS-NSSELLITYSDELIYLFQKNMGLGPSPLTVSSENLLRELKRPQVFSGHRNSAT

Query:  VKGVNFFGPNAEYIVSGSDCGHIYIWKKKGALLVKLMLGDH-DVVNHIEPHPHLPILATCGIENNVKIWTPMATDVPPLPDAMEQIMESNKQGREEHS--
        VKGVNF+GP +E++VSGSDCGHI++W+K    +++ M GD   VVN +EPHPHLP+LAT G++++VKIW P A     L   ++ +++ NK+ R+E S  
Subjt:  VKGVNFFGPNAEYIVSGSDCGHIYIWKKKGALLVKLMLGDH-DVVNHIEPHPHLPILATCGIENNVKIWTPMATDVPPLPDAMEQIMESNKQGREEHS--

Query:  RVTLTPD----VIVHVLRLQRRQTSAFTERRYNPADINSD
           L        ++H LR QRR    + E      D +SD
Subjt:  RVTLTPD----VIVHVLRLQRRQTSAFTERRYNPADINSD

Q6NRH1 DDB1- and CUL4-associated factor 89.3e-8140.95Show/hide
Query:  RQIGIVPSTNFSRRFIASEIIVKQLNLEHKLNGHDGCVNAVEFNSTGDLLVSGSDDCKVILWDWARNSKRFSYPSGHLDNIFQTKIMPFTDDQKIVTSAA
        RQ+G   ST F      +   V++ +L H L+GH GCVN + FN  G  L SGSDD KV++WDW R      + SGH  N+FQ K +P + D  +   A 
Subjt:  RQIGIVPSTNFSRRFIASEIIVKQLNLEHKLNGHDGCVNAVEFNSTGDLLVSGSDDCKVILWDWARNSKRFSYPSGHLDNIFQTKIMPFTDDQKIVTSAA

Query:  DGKVRLGQVLGDGRV-ITQMLGEHQGSVHELAVEPGSPHIFYSCGEDGLVQHFDLRNTSARKLFYCTAFAERSRHPPNSIELNAIAIDPRNPNFFALGGS
        DG+VR+ ++        T+ + +H+G+ H+LA+EP SP  F S GED +V   DLR          T      +   + + L  I ++P N   FA+GG 
Subjt:  DGKVRLGQVLGDGRV-ITQMLGEHQGSVHELAVEPGSPHIFYSCGEDGLVQHFDLRNTSARKLFYCTAFAERSRHPPNSIELNAIAIDPRNPNFFALGGS

Query:  DEYARLYDLRNCRGDVTSSNRVVDTFCPHHL-TQTNNFHITGLAFS-NSSELLITYSDELIYLFQKNMGLGPSPLTVSSENLLRELKRPQVFSGHRNSAT
        D++ R+YD R    +V  +N V+  FCPHHL T     +IT L +S + SELL +Y+DE IYLF  +   G              +KR   + GHRN+AT
Subjt:  DEYARLYDLRNCRGDVTSSNRVVDTFCPHHL-TQTNNFHITGLAFS-NSSELLITYSDELIYLFQKNMGLGPSPLTVSSENLLRELKRPQVFSGHRNSAT

Query:  VKGVNFFGPNAEYIVSGSDCGHIYIWKKKGALLVKLMLGDH-DVVNHIEPHPHLPILATCGIENNVKIWTPMATDVPPLPDAMEQIMESNKQGREEHS
        VKGVNF+GP +E++VSGSDCGHI++W+K    +V+ M GD   VVN +EPHPHLP+LAT G++ +VKIW P A + P   D ++++++ NK+ R+E S
Subjt:  VKGVNFFGPNAEYIVSGSDCGHIYIWKKKGALLVKLMLGDH-DVVNHIEPHPHLPILATCGIENNVKIWTPMATDVPPLPDAMEQIMESNKQGREEHS

Q8N7N5 DDB1- and CUL4-associated factor 85.5e-8138.64Show/hide
Query:  RQIGIVPSTNFSRRFIASEIIVKQLNLEHKLNGHDGCVNAVEFNSTGDLLVSGSDDCKVILWDWARNSKRFSYPSGHLDNIFQTKIMPFTDDQKIVTSAA
        R++G   S  F      + + V++  L+H L GH GCVN + FN  G  L SGSDD KV++WDW R      + SGH  N+FQ K +P + D  +   A 
Subjt:  RQIGIVPSTNFSRRFIASEIIVKQLNLEHKLNGHDGCVNAVEFNSTGDLLVSGSDDCKVILWDWARNSKRFSYPSGHLDNIFQTKIMPFTDDQKIVTSAA

Query:  DGKVRLGQVLGDGRV-ITQMLGEHQGSVHELAVEPGSPHIFYSCGEDGLVQHFDLRNTSARKLFYCTAFAERSRHPPNSIELNAIAIDPRNPNFFALGGS
        DG+VR+ ++        T+ + +H+G+ H+LA+EP SP  F S GED +V   DLR          T   E+       + L  I ++P N + FA+GG 
Subjt:  DGKVRLGQVLGDGRV-ITQMLGEHQGSVHELAVEPGSPHIFYSCGEDGLVQHFDLRNTSARKLFYCTAFAERSRHPPNSIELNAIAIDPRNPNFFALGGS

Query:  DEYARLYDLRNCRGDVTSSNRVVDTFCPHHLTQT-NNFHITGLAFS-NSSELLITYSDELIYLFQKNMGLGPSPLTVSSENLLRELKRPQVFSGHRNSAT
        D+Y R+YD R    D   +N V+  FCPHHL  + +  +IT L +S + +ELL +Y+DE IYLF  +   G            + +KR   + GHRN+AT
Subjt:  DEYARLYDLRNCRGDVTSSNRVVDTFCPHHLTQT-NNFHITGLAFS-NSSELLITYSDELIYLFQKNMGLGPSPLTVSSENLLRELKRPQVFSGHRNSAT

Query:  VKGVNFFGPNAEYIVSGSDCGHIYIWKKKGALLVKLMLGDH-DVVNHIEPHPHLPILATCGIENNVKIWTPMATDVPPLPDAMEQIMESNKQGREEHS--
        VKGVNF+GP +E++VSGSDCGHI++W+K    +++ M GD   VVN +EPHPHLP+LAT G++++VKIW P A     L   ++++++ NK+ R+E S  
Subjt:  VKGVNFFGPNAEYIVSGSDCGHIYIWKKKGALLVKLMLGDH-DVVNHIEPHPHLPILATCGIENNVKIWTPMATDVPPLPDAMEQIMESNKQGREEHS--

Query:  RVTLTPD----VIVHVLRLQRRQTSAFTERRYNPADINSD
           L        ++H LR QRR    + E      D +SD
Subjt:  RVTLTPD----VIVHVLRLQRRQTSAFTERRYNPADINSD

Arabidopsis top hitse value%identityAlignment
AT3G45620.1 Transducin/WD40 repeat-like superfamily protein5.3e-16458.49Show/hide
Query:  FAEICNRQIGIVPSTNFSRRFIASEIIVKQLNLEHKLNGHDGCVNAVEFNSTGDLLVSGSDDCKVILWDWARNSKRFSYPSGHLDNIFQTKIMPFTDDQK
        F EI NR+IG       SRR  ASE  VK+L+L  KLNGH+GCVNAVEFNSTGD+LVSGSDD +++LW+W   S++ SYPSGH +N+FQTK +PFTDD+ 
Subjt:  FAEICNRQIGIVPSTNFSRRFIASEIIVKQLNLEHKLNGHDGCVNAVEFNSTGDLLVSGSDDCKVILWDWARNSKRFSYPSGHLDNIFQTKIMPFTDDQK

Query:  IVTSAADGKVRLGQVLGDGRVITQMLGEHQGSVHELAVEPGSPHIFYSCGEDGLVQHFDLRNTSARKLFYCTAFAE--RSRHPPNSIELNAIAIDPRNPN
        I+TS ADG+VRLGQ+L +G+V T+ LG H G V++LAV PG P++FYSCGEDG VQHFD+R+ SA  + Y + F +  R  H  + I LN+IAIDPRN  
Subjt:  IVTSAADGKVRLGQVLGDGRVITQMLGEHQGSVHELAVEPGSPHIFYSCGEDGLVQHFDLRNTSARKLFYCTAFAE--RSRHPPNSIELNAIAIDPRNPN

Query:  FFALGGSDEYARLYDLRN------CRGDVTSSNRVVDTFCPHHLTQTNNFHITGLAFSNSSELLITYSDELIYLFQKNMGLGPSPLTVSSENLLRELKRP
        + A+GGSDEYAR+YD R       CR  +  +   V+TFCP HL +TN+ HITGLA+S + ELL++Y+DELIYLF+KNMG G SP++VS E  L+E++ P
Subjt:  FFALGGSDEYARLYDLRN------CRGDVTSSNRVVDTFCPHHLTQTNNFHITGLAFSNSSELLITYSDELIYLFQKNMGLGPSPLTVSSENLLRELKRP

Query:  QVFSGHRNSATVKGVNFFGPNAEYIVSGSDCGHIYIWKKKGALLVKLMLGDHDVVNHIEPHPHLPILATCGIENNVKIWTPMATDVPPLPDAMEQIMESN
        QV+ GHRN+ TVKGVNFFGPN EY+ SGSDCGHI+IWKKKG  LV+ M+GD  VVN +E HPH+P+LA+CGIE +VK+WTPM+ DV  LP+ ++++ME N
Subjt:  QVFSGHRNSATVKGVNFFGPNAEYIVSGSDCGHIYIWKKKGALLVKLMLGDHDVVNHIEPHPHLPILATCGIENNVKIWTPMATDVPPLPDAMEQIMESN

Query:  KQGREEHSRVTLTPDVIVHVLRLQRRQTSAFTERRYNPADINSDGENEWEAYNQEALDGNVSFEDDSTEHASECNIS
        + GRE+ SRVTLTPDVI+HVLRLQRRQTSAFTERRY   DI SD     E  +   +   V+ +D+S++   EC +S
Subjt:  KQGREEHSRVTLTPDVIVHVLRLQRRQTSAFTERRYNPADINSDGENEWEAYNQEALDGNVSFEDDSTEHASECNIS

AT3G45620.2 Transducin/WD40 repeat-like superfamily protein3.0e-15954.6Show/hide
Query:  FAEICNRQIGIVPSTNFSRRFIASEI----------------------------------IVKQLNLEHKLNGHDGCVNAVEFNSTGDLLVSGSDDCKVI
        F EI NR+IG       SRR  ASE                                    VK+L+L  KLNGH+GCVNAVEFNSTGD+LVSGSDD +++
Subjt:  FAEICNRQIGIVPSTNFSRRFIASEI----------------------------------IVKQLNLEHKLNGHDGCVNAVEFNSTGDLLVSGSDDCKVI

Query:  LWDWARNSKRFSYPSGHLDNIFQTKIMPFTDDQKIVTSAADGKVRLGQVLGDGRVITQMLGEHQGSVHELAVEPGSPHIFYSCGEDGLVQHFDLRNTSAR
        LW+W   S++ SYPSGH +N+FQTK +PFTDD+ I+TS ADG+VRLGQ+L +G+V T+ LG H G V++LAV PG P++FYSCGEDG VQHFD+R+ SA 
Subjt:  LWDWARNSKRFSYPSGHLDNIFQTKIMPFTDDQKIVTSAADGKVRLGQVLGDGRVITQMLGEHQGSVHELAVEPGSPHIFYSCGEDGLVQHFDLRNTSAR

Query:  KLFYCTAFAE--RSRHPPNSIELNAIAIDPRNPNFFALGGSDEYARLYDLRN------CRGDVTSSNRVVDTFCPHHLTQTNNFHITGLAFSNSSELLIT
         + Y + F +  R  H  + I LN+IAIDPRN  + A+GGSDEYAR+YD R       CR  +  +   V+TFCP HL +TN+ HITGLA+S + ELL++
Subjt:  KLFYCTAFAE--RSRHPPNSIELNAIAIDPRNPNFFALGGSDEYARLYDLRN------CRGDVTSSNRVVDTFCPHHLTQTNNFHITGLAFSNSSELLIT

Query:  YSDELIYLFQKNMGLGPSPLTVSSENLLRELKRPQVFSGHRNSATVKGVNFFGPNAEYIVSGSDCGHIYIWKKKGALLVKLMLGDHDVVNHIEPHPHLPI
        Y+DELIYLF+KNMG G SP++VS E  L+E++ PQV+ GHRN+ TVKGVNFFGPN EY+ SGSDCGHI+IWKKKG  LV+ M+GD  VVN +E HPH+P+
Subjt:  YSDELIYLFQKNMGLGPSPLTVSSENLLRELKRPQVFSGHRNSATVKGVNFFGPNAEYIVSGSDCGHIYIWKKKGALLVKLMLGDHDVVNHIEPHPHLPI

Query:  LATCGIENNVKIWTPMATDVPPLPDAMEQIMESNKQGREEHSRVTLTPDVIVHVLRLQRRQTSAFTERRYNPADINSDGENEWEAYNQEALDGNVSFEDD
        LA+CGIE +VK+WTPM+ DV  LP+ ++++ME N+ GRE+ SRVTLTPDVI+HVLRLQRRQTSAFTERRY   DI SD     E  +   +   V+ +D+
Subjt:  LATCGIENNVKIWTPMATDVPPLPDAMEQIMESNKQGREEHSRVTLTPDVIVHVLRLQRRQTSAFTERRYNPADINSDGENEWEAYNQEALDGNVSFEDD

Query:  STEHASECNIS
        S++   EC +S
Subjt:  STEHASECNIS

AT4G35140.1 Transducin/WD40 repeat-like superfamily protein3.8e-12245.45Show/hide
Query:  YQGMNSDFAEICNRQIGIVPSTNFSRRFIASEIIVKQLNLEHKLNGHDGCVNAVEFNSTGDLLVSGSDDCKVILWDWARNSKRFSYPSGHLDNIFQTKIM
        + G++    +   R++G + S NFS RF ASE +V +L +  KL  H GCVN V FN+ GD+L+SGSDD +V+LWDW   + + S+ SGH +N+FQ K M
Subjt:  YQGMNSDFAEICNRQIGIVPSTNFSRRFIASEIIVKQLNLEHKLNGHDGCVNAVEFNSTGDLLVSGSDDCKVILWDWARNSKRFSYPSGHLDNIFQTKIM

Query:  PFTDDQKIVTSAADGKVRLGQVLGDGRVITQMLGEHQGSVHELAVEPGSPHIFYSCGEDGLVQHFDLRNTSARKLFYCTAFAERSRHPPNSIELNAIAID
        PF+DD+ IVT AADG VR   +L   +V T  LG HQG  H+L +EPG+PHIFY+CGEDGLVQ FDLR  +  +LF C +   R R+  ++I+LNAIAID
Subjt:  PFTDDQKIVTSAADGKVRLGQVLGDGRVITQMLGEHQGSVHELAVEPGSPHIFYSCGEDGLVQHFDLRNTSARKLFYCTAFAERSRHPPNSIELNAIAID

Query:  PRNPNFFALGGSDEYARLYDLRNCRGD-VTSSNRVVDTFCPHHLTQTNNFHITGLAFSNSSELLITYSDELIYLFQKNMGLGPSPL--------------
        PRN N FA+GG +EYARLYD+R  +G+ +    R  D FCP HL    +  ITGLAFS  SELL++Y+DE IYLF   MGLG +P+              
Subjt:  PRNPNFFALGGSDEYARLYDLRNCRGD-VTSSNRVVDTFCPHHLTQTNNFHITGLAFSNSSELLITYSDELIYLFQKNMGLGPSPL--------------

Query:  TVSSENLLRELKRPQVFSGHRNSATVKGVNFFGPNAEYIVSGSDCGHIYIWKKKGALLVKLMLGDHDVVNHIEPHPHLPILATCGIENNVKIWTPMATDV
        + SS     E     V+ GH+N  TVKGVNFFGP +EY+VSGSDCG I+IW+KKG  L+++M  D  VVN IEPHPH+P+LA+ GIE+++K+WT  A + 
Subjt:  TVSSENLLRELKRPQVFSGHRNSATVKGVNFFGPNAEYIVSGSDCGHIYIWKKKGALLVKLMLGDHDVVNHIEPHPHLPILATCGIENNVKIWTPMATDV

Query:  PPLPDAMEQIMESNKQGREEHSRVTLTPDVIVHVLRLQRRQTSAFTERRYNPADINSDGENEWEAYNQEALDGNVSFEDDSTEH
          LP   E I    +  R    RV+   +++  +  LQ R +S+      + +    +  +    +N ++ D N + +DD   H
Subjt:  PPLPDAMEQIMESNKQGREEHSRVTLTPDVIVHVLRLQRRQTSAFTERRYNPADINSDGENEWEAYNQEALDGNVSFEDDSTEH

AT4G38480.1 Transducin/WD40 repeat-like superfamily protein4.9e-11752.21Show/hide
Query:  ICNRQIGIVPSTNFSRRFIASEIIVKQLNLEHKLNGHDGCVNAVEFNSTGDLLVSGSDDCKVILWDWARNSKRFSYPSGHLDNIFQTKIMPFTDDQKIVT
        +  R++G++P+ +FS RF ASE ++++L L+ KL+ H GCVN V FN+ GD+L+SGSDD +VILWDW   S + S+ SGH +NIFQ K MPF+DD+ IVT
Subjt:  ICNRQIGIVPSTNFSRRFIASEIIVKQLNLEHKLNGHDGCVNAVEFNSTGDLLVSGSDDCKVILWDWARNSKRFSYPSGHLDNIFQTKIMPFTDDQKIVT

Query:  SAADGKVRLGQVLGDGRVITQMLGEHQGSVHELAVEPGSPHIFYSCGEDGLVQHFDLRNTSARKLFYCTAFAERSRHPPNSIELNAIAIDPRNPNFFALG
        SAAD +VR  ++L  G+V T +LG+HQG VH+LAVEPGSP  FY+CGEDG V+HFDLR   A  LF C     +       + L+AIA+DPRNP   A+ 
Subjt:  SAADGKVRLGQVLGDGRVITQMLGEHQGSVHELAVEPGSPHIFYSCGEDGLVQHFDLRNTSARKLFYCTAFAERSRHPPNSIELNAIAIDPRNPNFFALG

Query:  GSDEYARLYDLRNCRGD-VTSSNRVVDTFCPHHLTQTNNFHITGLAFSNSSELLITYSDELIYLFQKNMGLGPSPLTVSSENLLRELKRPQVFSGHRNSA
        G DEYAR+YD+R+ R +   +  + +D FCP HL   ++  ITGLAFS+ SELL +YSDE IYLF  +MGLGP+P   S++    E   PQV+  H N  
Subjt:  GSDEYARLYDLRNCRGD-VTSSNRVVDTFCPHHLTQTNNFHITGLAFSNSSELLITYSDELIYLFQKNMGLGPSPLTVSSENLLRELKRPQVFSGHRNSA

Query:  TVKGVNFFGPNAEYIVSGSDCGHIYIWKKKGALLVKLMLGDHDVVNHIEPHPHLPILATCGIENNVKIWTPMATDVPPLPDAMEQ
        TVKGVNFFGP  EY+VSGSDCG I+IW+KK   L++ M  D  VVN IE HPH+P++ + GI+ ++KIWTP  T+ P  P   +Q
Subjt:  TVKGVNFFGPNAEYIVSGSDCGHIYIWKKKGALLVKLMLGDHDVVNHIEPHPHLPILATCGIENNVKIWTPMATDVPPLPDAMEQ

AT5G10940.2 transducin family protein / WD-40 repeat family protein1.2e-4334.02Show/hide
Query:  PSTNFSRRFIASEIIVKQLNLEHKLNGHDGCVNAVEFNSTGDLLVSGSDDCKVILWDWARNSKRFSYPSGHLDNIFQTKIMPFTDDQKIVTSAADGKVRL
        PS    +R      +V++L+ E +L GH GCVNA+ +NS G LL+SGSDD ++ +W+++      S  +GH  NIF TK +P T D+ +V+ A D +VRL
Subjt:  PSTNFSRRFIASEIIVKQLNLEHKLNGHDGCVNAVEFNSTGDLLVSGSDDCKVILWDWARNSKRFSYPSGHLDNIFQTKIMPFTDDQKIVTSAADGKVRL

Query:  -------GQVLGDGRVITQMLGE-HQGSVHELAVEPGSPHIFYSCGEDGLVQHFDLRNTSA------------RKLFYCTAFAER--SRHPPNSIELNAI
               G+   D  +I   L + H   V +LAVEPG+P++ +S  EDG ++  D R +++              L    + A+R  +  P  ++ L + 
Subjt:  -------GQVLGDGRVITQMLGE-HQGSVHELAVEPGSPHIFYSCGEDGLVQHFDLRNTSA------------RKLFYCTAFAER--SRHPPNSIELNAI

Query:  AIDPRNPNFFALGGSDEYARLYDLRNCRGDVTSSNRV-----VDTFCPHHLTQ--TNNFHITGLAFS-NSSELLITYSDELIYLFQKNMGLGPSPLT---
         I    P+   +GGSD +ARLYD R      +S  R+     V+ FCP HL++    N H+T + FS N  E+L++YS E +YL   N G G    T   
Subjt:  AIDPRNPNFFALGGSDEYARLYDLRNCRGDVTSSNRV-----VDTFCPHHLTQ--TNNFHITGLAFS-NSSELLITYSDELIYLFQKNMGLGPSPLT---

Query:  ----VSSENLLRELKRPQVFSG------HR--NSATVK
             S  N L +++ P   S       HR  N+ATVK
Subjt:  ----VSSENLLRELKRPQVFSG------HR--NSATVK

AT5G10940.2 transducin family protein / WD-40 repeat family protein4.0e-1834.21Show/hide
Query:  ELKRPQVFSGHRNSAT-VKGVNFFGPNAEYIVSGSDCGHIYIWKKKGALLVKLMLGDHDVVNHIEPHPHLPILATCGIENNVKIWTPMAT--------DV
        ++KR  V  GH N  T +K  +F G   EYI SGSD G  +IW+K+   L+K+++GD  V+N I+ HP   ++AT GI+N +KIW+P A+          
Subjt:  ELKRPQVFSGHRNSAT-VKGVNFFGPNAEYIVSGSDCGHIYIWKKKGALLVKLMLGDHDVVNHIEPHPHLPILATCGIENNVKIWTPMAT--------DV

Query:  PPLPDAMEQIMESNKQGREEHSRVTLTPDVIVHVLRLQRRQTSAFTERRYNP
         P    + ++MESN+Q    +    L+ ++      +QR +   F E  ++P
Subjt:  PPLPDAMEQIMESNKQGREEHSRVTLTPDVIVHVLRLQRRQTSAFTERRYNP


Sequences Show/hide sequences
CDS sequenceShow/hide CDS sequence
ATGAATCCTTGTTACCAAGGAATGAACTCTGACTTTGCTGAAATTTGCAACAGACAAATCGGTATTGTTCCATCAACAAACTTCTCTCGCAGATTCATTGCTTCAGAGAT
TATTGTAAAACAGTTGAATCTTGAACACAAGTTAAATGGTCACGATGGCTGTGTAAACGCCGTCGAGTTTAACTCCACTGGCGATCTTCTTGTGTCCGGTTCCGATGACT
GCAAAGTCATACTCTGGGATTGGGCAAGAAATTCTAAGAGGTTTTCGTATCCTTCTGGTCACCTCGACAACATATTCCAAACCAAAATTATGCCGTTCACTGATGATCAG
AAAATAGTAACTTCAGCTGCCGATGGAAAGGTAAGACTTGGGCAAGTCTTGGGTGATGGCAGAGTTATTACCCAAATGTTAGGGGAGCATCAAGGCTCTGTTCATGAACT
TGCTGTGGAGCCTGGAAGCCCTCACATATTTTACAGCTGCGGCGAAGACGGTCTTGTGCAGCATTTCGATCTACGCAATACTTCTGCAAGAAAACTTTTCTATTGCACCG
CATTTGCCGAAAGGAGCAGGCATCCTCCTAACAGTATTGAACTGAATGCCATTGCTATTGACCCAAGAAATCCAAATTTCTTTGCATTGGGTGGTTCAGATGAATATGCA
CGCTTGTATGATTTGAGAAATTGCCGAGGTGATGTTACAAGTTCGAATAGAGTTGTTGATACTTTCTGCCCACACCATTTGACCCAAACTAACAATTTCCACATCACGGG
ATTGGCTTTCTCAAATTCCAGCGAGCTGCTAATAACTTACAGTGACGAGCTTATTTATCTGTTTCAGAAGAATATGGGGCTAGGCCCCTCACCATTGACTGTCTCATCTG
AGAATTTGTTGCGGGAACTTAAACGGCCACAGGTTTTCTCTGGACACAGAAACTCAGCAACAGTTAAAGGGGTGAATTTCTTTGGCCCTAATGCAGAATATATTGTGAGT
GGCTCCGATTGTGGTCATATATATATTTGGAAGAAGAAGGGAGCTTTACTTGTGAAGTTAATGTTGGGTGATCATGATGTCGTAAATCATATCGAGCCCCATCCACACCT
GCCTATTCTTGCTACGTGTGGCATTGAAAATAATGTAAAAATTTGGACTCCCATGGCTACTGATGTTCCTCCATTGCCTGATGCCATGGAACAAATAATGGAGTCCAATA
AGCAAGGAAGAGAAGAGCACTCACGAGTGACCCTTACTCCTGATGTTATCGTGCATGTCCTGCGCCTGCAAAGAAGACAAACATCTGCATTTACGGAAAGACGATACAAC
CCAGCCGATATCAACAGTGATGGAGAAAATGAATGGGAAGCTTATAATCAAGAAGCCCTAGATGGCAATGTTTCTTTTGAAGATGATTCCACAGAACATGCTTCCGAGTG
TAACATCAGCTAG
mRNA sequenceShow/hide mRNA sequence
ATGAATCCTTGTTACCAAGGAATGAACTCTGACTTTGCTGAAATTTGCAACAGACAAATCGGTATTGTTCCATCAACAAACTTCTCTCGCAGATTCATTGCTTCAGAGAT
TATTGTAAAACAGTTGAATCTTGAACACAAGTTAAATGGTCACGATGGCTGTGTAAACGCCGTCGAGTTTAACTCCACTGGCGATCTTCTTGTGTCCGGTTCCGATGACT
GCAAAGTCATACTCTGGGATTGGGCAAGAAATTCTAAGAGGTTTTCGTATCCTTCTGGTCACCTCGACAACATATTCCAAACCAAAATTATGCCGTTCACTGATGATCAG
AAAATAGTAACTTCAGCTGCCGATGGAAAGGTAAGACTTGGGCAAGTCTTGGGTGATGGCAGAGTTATTACCCAAATGTTAGGGGAGCATCAAGGCTCTGTTCATGAACT
TGCTGTGGAGCCTGGAAGCCCTCACATATTTTACAGCTGCGGCGAAGACGGTCTTGTGCAGCATTTCGATCTACGCAATACTTCTGCAAGAAAACTTTTCTATTGCACCG
CATTTGCCGAAAGGAGCAGGCATCCTCCTAACAGTATTGAACTGAATGCCATTGCTATTGACCCAAGAAATCCAAATTTCTTTGCATTGGGTGGTTCAGATGAATATGCA
CGCTTGTATGATTTGAGAAATTGCCGAGGTGATGTTACAAGTTCGAATAGAGTTGTTGATACTTTCTGCCCACACCATTTGACCCAAACTAACAATTTCCACATCACGGG
ATTGGCTTTCTCAAATTCCAGCGAGCTGCTAATAACTTACAGTGACGAGCTTATTTATCTGTTTCAGAAGAATATGGGGCTAGGCCCCTCACCATTGACTGTCTCATCTG
AGAATTTGTTGCGGGAACTTAAACGGCCACAGGTTTTCTCTGGACACAGAAACTCAGCAACAGTTAAAGGGGTGAATTTCTTTGGCCCTAATGCAGAATATATTGTGAGT
GGCTCCGATTGTGGTCATATATATATTTGGAAGAAGAAGGGAGCTTTACTTGTGAAGTTAATGTTGGGTGATCATGATGTCGTAAATCATATCGAGCCCCATCCACACCT
GCCTATTCTTGCTACGTGTGGCATTGAAAATAATGTAAAAATTTGGACTCCCATGGCTACTGATGTTCCTCCATTGCCTGATGCCATGGAACAAATAATGGAGTCCAATA
AGCAAGGAAGAGAAGAGCACTCACGAGTGACCCTTACTCCTGATGTTATCGTGCATGTCCTGCGCCTGCAAAGAAGACAAACATCTGCATTTACGGAAAGACGATACAAC
CCAGCCGATATCAACAGTGATGGAGAAAATGAATGGGAAGCTTATAATCAAGAAGCCCTAGATGGCAATGTTTCTTTTGAAGATGATTCCACAGAACATGCTTCCGAGTG
TAACATCAGCTAG
Protein sequenceShow/hide protein sequence
MNPCYQGMNSDFAEICNRQIGIVPSTNFSRRFIASEIIVKQLNLEHKLNGHDGCVNAVEFNSTGDLLVSGSDDCKVILWDWARNSKRFSYPSGHLDNIFQTKIMPFTDDQ
KIVTSAADGKVRLGQVLGDGRVITQMLGEHQGSVHELAVEPGSPHIFYSCGEDGLVQHFDLRNTSARKLFYCTAFAERSRHPPNSIELNAIAIDPRNPNFFALGGSDEYA
RLYDLRNCRGDVTSSNRVVDTFCPHHLTQTNNFHITGLAFSNSSELLITYSDELIYLFQKNMGLGPSPLTVSSENLLRELKRPQVFSGHRNSATVKGVNFFGPNAEYIVS
GSDCGHIYIWKKKGALLVKLMLGDHDVVNHIEPHPHLPILATCGIENNVKIWTPMATDVPPLPDAMEQIMESNKQGREEHSRVTLTPDVIVHVLRLQRRQTSAFTERRYN
PADINSDGENEWEAYNQEALDGNVSFEDDSTEHASECNIS