CuGenDBv2

Gene ID	Chy3G053670
Organism	Cucumis hystrix (Cucumber (hystrix) v1)
Description	gamma-secretase subunit APH1-like
Genome location	chrH03:5401838..5406795
RNA-Seq Expression	Chy3G053670
Synteny	Chy3G053670
Gene Ontology terms	GO:0007219 - Notch signaling pathway (biological process) GO:0016485 - protein processing (biological process) GO:0043085 - positive regulation of catalytic activity (biological process) GO:0005783 - endoplasmic reticulum (cellular component) GO:0016021 - integral component of membrane (cellular component) GO:0070765 - gamma-secretase complex (cellular component) GO:0030674 - protein binding, bridging (molecular function)
InterPro domains	IPR009294 - Gamma-secretase subunit Aph-1

Homology

Show/hide homology

GenBank top hits

e value

%identity

Alignment

KAA0033075.1 gamma-secretase subunit APH1-like [Cucumis melo var. makuwa]

1.35e-129

99.01

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Query:  MTVSAGIGYTLIALGPSLSLFISVIAHKPFLILTLLSSTLLWLISLILLSALWRGFLPLNSTVLWPYAILILTSVIFQEVLRVLFWKVYRRLEDMLDAFA
        MTVSAGIGYTLIALGPSLSLFISVIAHKPFLILTLLSSTLLWLISLILLSALWRGFLPLNSTVLWPY ILILTSVIFQEVLRVLFWKVYRRLEDMLDAFA
Subjt:  MTVSAGIGYTLIALGPSLSLFISVIAHKPFLILTLLSSTLLWLISLILLSALWRGFLPLNSTVLWPYAILILTSVIFQEVLRVLFWKVYRRLEDMLDAFA

Query:  DRVSKPHLYLTDKMQIALAGGLGHGISHAVFFCLSLLTPSFGPATYFVDRCSQLPFFLVSAIIALAFVTIHTFSMVIAFNGYSEGKKVDQYFVPVIHLAA
        DRVSKP LYLTDKMQIALAGGLGHGISHAVFFCLSLLTPSFGPATYFVDRCSQLPFFLVSAIIALAFVTIHTFSMVIAFNGYSEGKKVDQYFVPVIHLAA
Subjt:  DRVSKPHLYLTDKMQIALAGGLGHGISHAVFFCLSLLTPSFGPATYFVDRCSQLPFFLVSAIIALAFVTIHTFSMVIAFNGYSEGKKVDQYFVPVIHLAA

Query:  GMV
        GMV
Subjt:  GMV

XP_004140879.1 gamma-secretase subunit APH1-like [Cucumis sativus]

3.31e-130

98.52

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Query:  MTVSAGIGYTLIALGPSLSLFISVIAHKPFLILTLLSSTLLWLISLILLSALWRGFLPLNSTVLWPYAILILTSVIFQEVLRVLFWKVYRRLEDMLDAFA
        MTVSAGIGYTLIALGPSLSLFISVIAHKPFLILTLLSSTLLWLISLILLSALWRGFLPLNSTV WPYAILILTSVIFQEVLRVLFWKVYRRLEDMLDAFA
Subjt:  MTVSAGIGYTLIALGPSLSLFISVIAHKPFLILTLLSSTLLWLISLILLSALWRGFLPLNSTVLWPYAILILTSVIFQEVLRVLFWKVYRRLEDMLDAFA

Query:  DRVSKPHLYLTDKMQIALAGGLGHGISHAVFFCLSLLTPSFGPATYFVDRCSQLPFFLVSAIIALAFVTIHTFSMVIAFNGYSEGKKVDQYFVPVIHLAA
        DRVSKP LYL DKMQIALAGGLGHGISHAVFFCLSLLTPSFGPATYFVDRCSQLPFFLVSAIIALAFVTIHTFSMVIAFNGYSEGKKVDQYFVPVIHLAA
Subjt:  DRVSKPHLYLTDKMQIALAGGLGHGISHAVFFCLSLLTPSFGPATYFVDRCSQLPFFLVSAIIALAFVTIHTFSMVIAFNGYSEGKKVDQYFVPVIHLAA

Query:  GMV
        GMV
Subjt:  GMV

XP_008445715.1 PREDICTED: gamma-secretase subunit APH1-like [Cucumis melo]

3.39e-131

99.01

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Query:  MTVSAGIGYTLIALGPSLSLFISVIAHKPFLILTLLSSTLLWLISLILLSALWRGFLPLNSTVLWPYAILILTSVIFQEVLRVLFWKVYRRLEDMLDAFA
        MTVSAGIGYTLIALGPSLSLFISVIAHKPFLILTLLSSTLLWLISLILLSALWRGFLPLNSTVLWPY ILILTSVIFQEVLRVLFWKVYRRLEDMLDAFA
Subjt:  MTVSAGIGYTLIALGPSLSLFISVIAHKPFLILTLLSSTLLWLISLILLSALWRGFLPLNSTVLWPYAILILTSVIFQEVLRVLFWKVYRRLEDMLDAFA

Query:  DRVSKPHLYLTDKMQIALAGGLGHGISHAVFFCLSLLTPSFGPATYFVDRCSQLPFFLVSAIIALAFVTIHTFSMVIAFNGYSEGKKVDQYFVPVIHLAA
        DRVSKP LYLTDKMQIALAGGLGHGISHAVFFCLSLLTPSFGPATYFVDRCSQLPFFLVSAIIALAFVTIHTFSMVIAFNGYSEGKKVDQYFVPVIHLAA
Subjt:  DRVSKPHLYLTDKMQIALAGGLGHGISHAVFFCLSLLTPSFGPATYFVDRCSQLPFFLVSAIIALAFVTIHTFSMVIAFNGYSEGKKVDQYFVPVIHLAA

Query:  GMV
        GMV
Subjt:  GMV

XP_023549211.1 gamma-secretase subunit APH1-like [Cucurbita pepo subsp. pepo]

1.61e-129

96.55

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Query:  MTVSAGIGYTLIALGPSLSLFISVIAHKPFLILTLLSSTLLWLISLILLSALWRGFLPLNSTVLWPYAILILTSVIFQEVLRVLFWKVYRRLEDMLDAFA
        MTV+AGIGYTLIALGPSLSLFISVIAHKPFLILTLLSSTLLWLISLILLSALWRGFLPLNST+LWPYAILILTSVIFQE LRVLFWKVYR+LEDMLDAFA
Subjt:  MTVSAGIGYTLIALGPSLSLFISVIAHKPFLILTLLSSTLLWLISLILLSALWRGFLPLNSTVLWPYAILILTSVIFQEVLRVLFWKVYRRLEDMLDAFA

Query:  DRVSKPHLYLTDKMQIALAGGLGHGISHAVFFCLSLLTPSFGPATYFVDRCSQLPFFLVSAIIALAFVTIHTFSMVIAFNGYSEGKKVDQYFVPVIHLAA
        DRVSKP LYLTDKMQIALAGGLGHG++HAVFFCLSLLTPSFGPATYFVDRCSQLPFFLVSAIIALAFVTIHTFSMVIAFNGYSEGKKVDQYFVPVIHLAA
Subjt:  DRVSKPHLYLTDKMQIALAGGLGHGISHAVFFCLSLLTPSFGPATYFVDRCSQLPFFLVSAIIALAFVTIHTFSMVIAFNGYSEGKKVDQYFVPVIHLAA

Query:  GMV
        GMV
Subjt:  GMV

XP_038883993.1 gamma-secretase subunit APH1-like [Benincasa hispida]

5.60e-130

97.04

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Query:  MTVSAGIGYTLIALGPSLSLFISVIAHKPFLILTLLSSTLLWLISLILLSALWRGFLPLNSTVLWPYAILILTSVIFQEVLRVLFWKVYRRLEDMLDAFA
        MTV+AGIGYTLIALGPSLSLFISVIAHKPFLILTLLSSTLLWLISLILLSALWRGFLPLNST+LWPYAILILTSVIFQE LRVLFWKVYRRLEDMLDAFA
Subjt:  MTVSAGIGYTLIALGPSLSLFISVIAHKPFLILTLLSSTLLWLISLILLSALWRGFLPLNSTVLWPYAILILTSVIFQEVLRVLFWKVYRRLEDMLDAFA

Query:  DRVSKPHLYLTDKMQIALAGGLGHGISHAVFFCLSLLTPSFGPATYFVDRCSQLPFFLVSAIIALAFVTIHTFSMVIAFNGYSEGKKVDQYFVPVIHLAA
        DRVSKP LYLTDKMQIALAGGLGHGI+HAVFFCLSLLTPSFGPATYFVDRCSQLPFFL+SAIIALAFVTIHTFSMVIAFNGYSEGKKVDQYFVPVIHLAA
Subjt:  DRVSKPHLYLTDKMQIALAGGLGHGISHAVFFCLSLLTPSFGPATYFVDRCSQLPFFLVSAIIALAFVTIHTFSMVIAFNGYSEGKKVDQYFVPVIHLAA

Query:  GMV
        GMV
Subjt:  GMV

TrEMBL top hits

e value

%identity

Alignment

A0A0A0KB01 Uncharacterized protein

7.3e-102

98.52

Show/hide

Query:  MTVSAGIGYTLIALGPSLSLFISVIAHKPFLILTLLSSTLLWLISLILLSALWRGFLPLNSTVLWPYAILILTSVIFQEVLRVLFWKVYRRLEDMLDAFA
        MTVSAGIGYTLIALGPSLSLFISVIAHKPFLILTLLSSTLLWLISLILLSALWRGFLPLNSTV WPYAILILTSVIFQEVLRVLFWKVYRRLEDMLDAFA
Subjt:  MTVSAGIGYTLIALGPSLSLFISVIAHKPFLILTLLSSTLLWLISLILLSALWRGFLPLNSTVLWPYAILILTSVIFQEVLRVLFWKVYRRLEDMLDAFA

Query:  DRVSKPHLYLTDKMQIALAGGLGHGISHAVFFCLSLLTPSFGPATYFVDRCSQLPFFLVSAIIALAFVTIHTFSMVIAFNGYSEGKKVDQYFVPVIHLAA
        DRVSKP LYL DKMQIALAGGLGHGISHAVFFCLSLLTPSFGPATYFVDRCSQLPFFLVSAIIALAFVTIHTFSMVIAFNGYSEGKKVDQYFVPVIHLAA
Subjt:  DRVSKPHLYLTDKMQIALAGGLGHGISHAVFFCLSLLTPSFGPATYFVDRCSQLPFFLVSAIIALAFVTIHTFSMVIAFNGYSEGKKVDQYFVPVIHLAA

Query:  GMV
        GMV
Subjt:  GMV

A0A1S3BDD6 gamma-secretase subunit APH1-like

1.1e-102

99.01

Show/hide

Query:  MTVSAGIGYTLIALGPSLSLFISVIAHKPFLILTLLSSTLLWLISLILLSALWRGFLPLNSTVLWPYAILILTSVIFQEVLRVLFWKVYRRLEDMLDAFA
        MTVSAGIGYTLIALGPSLSLFISVIAHKPFLILTLLSSTLLWLISLILLSALWRGFLPLNSTVLWPY ILILTSVIFQEVLRVLFWKVYRRLEDMLDAFA
Subjt:  MTVSAGIGYTLIALGPSLSLFISVIAHKPFLILTLLSSTLLWLISLILLSALWRGFLPLNSTVLWPYAILILTSVIFQEVLRVLFWKVYRRLEDMLDAFA

Query:  DRVSKPHLYLTDKMQIALAGGLGHGISHAVFFCLSLLTPSFGPATYFVDRCSQLPFFLVSAIIALAFVTIHTFSMVIAFNGYSEGKKVDQYFVPVIHLAA
        DRVSKP LYLTDKMQIALAGGLGHGISHAVFFCLSLLTPSFGPATYFVDRCSQLPFFLVSAIIALAFVTIHTFSMVIAFNGYSEGKKVDQYFVPVIHLAA
Subjt:  DRVSKPHLYLTDKMQIALAGGLGHGISHAVFFCLSLLTPSFGPATYFVDRCSQLPFFLVSAIIALAFVTIHTFSMVIAFNGYSEGKKVDQYFVPVIHLAA

Query:  GMV
        GMV
Subjt:  GMV

A0A5A7SV87 Gamma-secretase subunit APH1-like

8.6e-103

98.53

Show/hide

Query:  MTVSAGIGYTLIALGPSLSLFISVIAHKPFLILTLLSSTLLWLISLILLSALWRGFLPLNSTVLWPYAILILTSVIFQEVLRVLFWKVYRRLEDMLDAFA
        MTVSAGIGYTLIALGPSLSLFISVIAHKPFLILTLLSSTLLWLISLILLSALWRGFLPLNSTVLWPY ILILTSVIFQEVLRVLFWKVYRRLEDMLDAFA
Subjt:  MTVSAGIGYTLIALGPSLSLFISVIAHKPFLILTLLSSTLLWLISLILLSALWRGFLPLNSTVLWPYAILILTSVIFQEVLRVLFWKVYRRLEDMLDAFA

Query:  DRVSKPHLYLTDKMQIALAGGLGHGISHAVFFCLSLLTPSFGPATYFVDRCSQLPFFLVSAIIALAFVTIHTFSMVIAFNGYSEGKKVDQYFVPVIHLAA
        DRVSKP LYLTDKMQIALAGGLGHGISHAVFFCLSLLTPSFGPATYFVDRCSQLPFFLVSAIIALAFVTIHTFSMVIAFNGYSEGKKVDQYFVPVIHLAA
Subjt:  DRVSKPHLYLTDKMQIALAGGLGHGISHAVFFCLSLLTPSFGPATYFVDRCSQLPFFLVSAIIALAFVTIHTFSMVIAFNGYSEGKKVDQYFVPVIHLAA

Query:  GMVV
        GMV+
Subjt:  GMVV

A0A6J1ENY0 gamma-secretase subunit APH1-like

5.2e-100

95.07

Show/hide

Query:  MTVSAGIGYTLIALGPSLSLFISVIAHKPFLILTLLSSTLLWLISLILLSALWRGFLPLNSTVLWPYAILILTSVIFQEVLRVLFWKVYRRLEDMLDAFA
        MTV+AGIGYTLIALGPSL+LFISVI HKPFLILTLLSSTLLWLISLILLSALWRGFLPLNST+LWPYA LILTSVIFQE LRVLFWKVYR+LEDMLDAFA
Subjt:  MTVSAGIGYTLIALGPSLSLFISVIAHKPFLILTLLSSTLLWLISLILLSALWRGFLPLNSTVLWPYAILILTSVIFQEVLRVLFWKVYRRLEDMLDAFA

Query:  DRVSKPHLYLTDKMQIALAGGLGHGISHAVFFCLSLLTPSFGPATYFVDRCSQLPFFLVSAIIALAFVTIHTFSMVIAFNGYSEGKKVDQYFVPVIHLAA
        DRVSKP LYLTDKMQIALAGGLGHG++HAVFFCLSLLTPSFGPATYFVDRCSQLPFFLVSAIIALAFVTIHTFSMVIAFNGYSEGKKVDQYFVPVIHLAA
Subjt:  DRVSKPHLYLTDKMQIALAGGLGHGISHAVFFCLSLLTPSFGPATYFVDRCSQLPFFLVSAIIALAFVTIHTFSMVIAFNGYSEGKKVDQYFVPVIHLAA

Query:  GMV
        GMV
Subjt:  GMV

A0A6J1JZ07 gamma-secretase subunit APH1-like

1.8e-100

96.06

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Query:  MTVSAGIGYTLIALGPSLSLFISVIAHKPFLILTLLSSTLLWLISLILLSALWRGFLPLNSTVLWPYAILILTSVIFQEVLRVLFWKVYRRLEDMLDAFA
        MTV+AGIGYTLIALGPSLSLFISVIAHKPFLILTLLSSTLLWLISLILLSALWRGFLPLNST+LWPYAILILTSVIFQE LRVLFWKVYR+LEDMLDAFA
Subjt:  MTVSAGIGYTLIALGPSLSLFISVIAHKPFLILTLLSSTLLWLISLILLSALWRGFLPLNSTVLWPYAILILTSVIFQEVLRVLFWKVYRRLEDMLDAFA

Query:  DRVSKPHLYLTDKMQIALAGGLGHGISHAVFFCLSLLTPSFGPATYFVDRCSQLPFFLVSAIIALAFVTIHTFSMVIAFNGYSEGKKVDQYFVPVIHLAA
        DRVSKP LYLTDKMQIALAGGLGHG++HAVFFCLSLLTPSFGPATYFVDRCSQLPFFLVSAIIALAFVTIHTFSMVIAFNGYSE KKVDQYFVPVIHLAA
Subjt:  DRVSKPHLYLTDKMQIALAGGLGHGISHAVFFCLSLLTPSFGPATYFVDRCSQLPFFLVSAIIALAFVTIHTFSMVIAFNGYSEGKKVDQYFVPVIHLAA

Query:  GMV
        GMV
Subjt:  GMV

SwissProt top hits

e value

%identity

Alignment

Q8JHE9 Gamma-secretase subunit Aph-1b

1.2e-11

29.89

Show/hide

Query:  MTVSAGIGYTLIALGPSLSLFISVIAHKPFLILTLLSSTLLWLISLILLSALWRGFLPL---NSTVLWPYAIL--ILTSVIFQEVLRVLFWKVYRRLEDM
        MTV+   G T IA GP+++LF+  IA  P  ++ L++    WL+SL+L S +W   + +   NS       ++  ++ SV+ QE  R  ++++ ++  + 
Subjt:  MTVSAGIGYTLIALGPSLSLFISVIAHKPFLILTLLSSTLLWLISLILLSALWRGFLPL---NSTVLWPYAIL--ILTSVIFQEVLRVLFWKVYRRLEDM

Query:  LDAFADRVSKPHLYLTDKMQIALAGGLGHGISHAVFFCLSLLTPSFGPATYFVDRCSQLPFFLVSAIIALAFVTIHTFSMVIAF
        L A +   + P        Q+A   GLG G     F  +++L+ S GP T  +   SQ  +F+ SA + LA + +H F  V+ F
Subjt:  LDAFADRVSKPHLYLTDKMQIALAGGLGHGISHAVFFCLSLLTPSFGPATYFVDRCSQLPFFLVSAIIALAFVTIHTFSMVIAF

Q8L9G7 Gamma-secretase subunit APH1-like

2.4e-86

77.34

Show/hide

Query:  MTVSAGIGYTLIALGPSLSLFISVIAHKPFLILTLLSSTLLWLISLILLSALWRGFLPLNSTVLWPYAILILTSVIFQEVLRVLFWKVYRRLEDMLDAFA
        MTV+AGIGY L+ALGPSLSLF+SVI+ KPFLILT+LSSTLLWL+SLI+LS LWR FLPL + V WPYA+L++TSV FQE LR LFWKVY+RLED+LD+FA
Subjt:  MTVSAGIGYTLIALGPSLSLFISVIAHKPFLILTLLSSTLLWLISLILLSALWRGFLPLNSTVLWPYAILILTSVIFQEVLRVLFWKVYRRLEDMLDAFA

Query:  DRVSKPHLYLTDKMQIALAGGLGHGISHAVFFCLSLLTPSFGPATYFVDRCSQLPFFLVSAIIALAFVTIHTFSMVIAFNGYSEGKKVDQYFVPVIHLAA
        DR+S+P L+LTDK+QIALAGGLGHG++HAVFFCLSLLTP+FGPAT++V+RCS++PFFL+SAIIALAFVTIHTFSMVIAF GY++G KVDQ  VPVIHL A
Subjt:  DRVSKPHLYLTDKMQIALAGGLGHGISHAVFFCLSLLTPSFGPATYFVDRCSQLPFFLVSAIIALAFVTIHTFSMVIAFNGYSEGKKVDQYFVPVIHLAA

Query:  GMV
        GM+
Subjt:  GMV

Arabidopsis top hits

e value

%identity

Alignment

AT2G31440.1 INVOLVED IN: positive regulation of catalytic activity, protein processing; LOCATED IN: integral to membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Aph-1 (InterPro:IPR009294); Has 268 Blast hits to 262 proteins in 79 species: Archae - 0; Bacteria - 0; Metazoa - 212; Fungi - 0; Plants - 34; Viruses - 0; Other Eukaryotes - 22 (source: NCBI BLink).

1.7e-87

77.34

Show/hide

Query:  MTVSAGIGYTLIALGPSLSLFISVIAHKPFLILTLLSSTLLWLISLILLSALWRGFLPLNSTVLWPYAILILTSVIFQEVLRVLFWKVYRRLEDMLDAFA
        MTV+AGIGY L+ALGPSLSLF+SVI+ KPFLILT+LSSTLLWL+SLI+LS LWR FLPL + V WPYA+L++TSV FQE LR LFWKVY+RLED+LD+FA
Subjt:  MTVSAGIGYTLIALGPSLSLFISVIAHKPFLILTLLSSTLLWLISLILLSALWRGFLPLNSTVLWPYAILILTSVIFQEVLRVLFWKVYRRLEDMLDAFA

Query:  DRVSKPHLYLTDKMQIALAGGLGHGISHAVFFCLSLLTPSFGPATYFVDRCSQLPFFLVSAIIALAFVTIHTFSMVIAFNGYSEGKKVDQYFVPVIHLAA
        DR+S+P L+LTDK+QIALAGGLGHG++HAVFFCLSLLTP+FGPAT++V+RCS++PFFL+SAIIALAFVTIHTFSMVIAF GY++G KVDQ  VPVIHL A
Subjt:  DRVSKPHLYLTDKMQIALAGGLGHGISHAVFFCLSLLTPSFGPATYFVDRCSQLPFFLVSAIIALAFVTIHTFSMVIAFNGYSEGKKVDQYFVPVIHLAA

Query:  GMV
        GM+
Subjt:  GMV

Sequences

Show/hide sequences

CDS sequence

Show/hide CDS sequence

ATGACAGTATCAGCAGGGATCGGCTATACCTTGATAGCCTTGGGCCCTTCTCTCTCCCTTTTCATCTCCGTCATTGCTCACAAGCCATTCTTAATTCTCACTCTC
CTCTCCAGCACCCTGTTATGGCTCATTAGTTTGATATTGCTGTCTGCGTTATGGAGGGGGTTTCTTCCACTGAATTCAACAGTATTGTGGCCGTATGCAATTCTT
ATTTTGACTTCGGTCATTTTTCAAGAAGTTCTACGGGTTCTTTTCTGGAAAGTCTACAGGAGGTTAGAAGATATGTTAGATGCTTTTGCTGACAGAGTTTCAAAG
CCGCACCTATATTTAACAGATAAGATGCAGATTGCTCTAGCTGGGGGTTTAGGTCATGGCATATCTCATGCTGTGTTTTTCTGTCTTAGCCTTTTAACTCCCTCA
TTTGGTCCAGCGACGTACTTCGTTGATAGATGCTCCCAACTACCCTTTTTTCTTGTTTCAGCTATCATTGCTCTTGCATTTGTTACAATCCATACTTTCTCTATG
GTCATTGCATTCAATGGGTATTCAGAGGGGAAGAAAGTGGACCAATATTTTGTTCCAGTCATACATCTTGCCGCAGGAATGGTGGTAAAACTCTAA

mRNA sequence

Show/hide mRNA sequence

Protein sequence

Show/hide protein sequence

MTVSAGIGYTLIALGPSLSLFISVIAHKPFLILTLLSSTLLWLISLILLSALWRGFLPLNSTVLWPYAILILTSVIFQEVLRVLFWKVYRRLEDMLDAFADRVSK
PHLYLTDKMQIALAGGLGHGISHAVFFCLSLLTPSFGPATYFVDRCSQLPFFLVSAIIALAFVTIHTFSMVIAFNGYSEGKKVDQYFVPVIHLAAGMVVKL

Chy3G053670 (gene) of Cucumber (hystrix) v1 genome