CuGenDBv2

Gene ID	CmaCh06G012080
Organism	Cucurbita maxima Rimu (Cucurbita maxima (Rimu) v1.1)
Description	Hydroxyisourate hydrolase
Genome location	Cma_Chr06:8060614..8062597
RNA-Seq Expression	CmaCh06G012080
Synteny	CmaCh06G012080
Gene Ontology terms	GO:0001560 - regulation of cell growth by extracellular stimulus (biological process) GO:0006144 - purine nucleobase metabolic process (biological process) GO:0009742 - brassinosteroid mediated signaling pathway (biological process) GO:0019428 - allantoin biosynthetic process (biological process) GO:0005777 - peroxisome (cellular component) GO:0005829 - cytosol (cellular component) GO:0031234 - extrinsic component of cytoplasmic side of plasma membrane (cellular component) GO:0033971 - hydroxyisourate hydrolase activity (molecular function) GO:0042802 - identical protein binding (molecular function) GO:0051997 - 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase activity (molecular function)
InterPro domains	IPR018020 - Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase IPR036778 - Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase superfamily

Homology

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GenBank top hits

e value

%identity

Alignment

XP_022946215.1 uric acid degradation bifunctional protein TTL isoform X1 [Cucurbita moschata]

4.6e-75

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Query:  MAASYDFGEEEFQACCGSSKFAREMVSVSPFFSLEQAMQLDASGLMVSVSPFFSLEQAVDAARRIWFNQVDVNGWLEAFSAHPQIGQASKSSNQTSAQWS
        MAASYDFGEEEFQACCGSSKFARE                     MVSVSPFFSLEQAVDAARRIWFNQVDVNGWLEAFSAHPQIGQASKSSNQTSAQWS
Subjt:  MAASYDFGEEEFQACCGSSKFAREMVSVSPFFSLEQAMQLDASGLMVSVSPFFSLEQAVDAARRIWFNQVDVNGWLEAFSAHPQIGQASKSSNQTSAQWS

Query:  KGEQSTALATATGSSLQELAEWNIQYQKKFGFIFLICASGRSTDEILAELKKRYSNRPIVEFEIAAQEQMKITEL
        KGEQSTALATATGSSLQELAEWNIQYQKKFGFIFLICASGRSTDEILAELKKRYSNRPIVEFEIAAQEQMKITEL
Subjt:  KGEQSTALATATGSSLQELAEWNIQYQKKFGFIFLICASGRSTDEILAELKKRYSNRPIVEFEIAAQEQMKITEL

XP_022946227.1 uric acid degradation bifunctional protein TTL isoform X2 [Cucurbita moschata]

4.6e-75

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Query:  MAASYDFGEEEFQACCGSSKFAREMVSVSPFFSLEQAMQLDASGLMVSVSPFFSLEQAVDAARRIWFNQVDVNGWLEAFSAHPQIGQASKSSNQTSAQWS
        MAASYDFGEEEFQACCGSSKFARE                     MVSVSPFFSLEQAVDAARRIWFNQVDVNGWLEAFSAHPQIGQASKSSNQTSAQWS
Subjt:  MAASYDFGEEEFQACCGSSKFAREMVSVSPFFSLEQAMQLDASGLMVSVSPFFSLEQAVDAARRIWFNQVDVNGWLEAFSAHPQIGQASKSSNQTSAQWS

Query:  KGEQSTALATATGSSLQELAEWNIQYQKKFGFIFLICASGRSTDEILAELKKRYSNRPIVEFEIAAQEQMKITEL
        KGEQSTALATATGSSLQELAEWNIQYQKKFGFIFLICASGRSTDEILAELKKRYSNRPIVEFEIAAQEQMKITEL
Subjt:  KGEQSTALATATGSSLQELAEWNIQYQKKFGFIFLICASGRSTDEILAELKKRYSNRPIVEFEIAAQEQMKITEL

XP_022974962.1 uric acid degradation bifunctional protein TTL-like, partial [Cucurbita maxima]

4.6e-75

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Query:  MAASYDFGEEEFQACCGSSKFAREMVSVSPFFSLEQAMQLDASGLMVSVSPFFSLEQAVDAARRIWFNQVDVNGWLEAFSAHPQIGQASKSSNQTSAQWS
        MAASYDFGEEEFQACCGSSKFARE                     MVSVSPFFSLEQAVDAARRIWFNQVDVNGWLEAFSAHPQIGQASKSSNQTSAQWS
Subjt:  MAASYDFGEEEFQACCGSSKFAREMVSVSPFFSLEQAMQLDASGLMVSVSPFFSLEQAVDAARRIWFNQVDVNGWLEAFSAHPQIGQASKSSNQTSAQWS

Query:  KGEQSTALATATGSSLQELAEWNIQYQKKFGFIFLICASGRSTDEILAELKKRYSNRPIVEFEIAAQEQMKITEL
        KGEQSTALATATGSSLQELAEWNIQYQKKFGFIFLICASGRSTDEILAELKKRYSNRPIVEFEIAAQEQMKITEL
Subjt:  KGEQSTALATATGSSLQELAEWNIQYQKKFGFIFLICASGRSTDEILAELKKRYSNRPIVEFEIAAQEQMKITEL

XP_023540276.1 uric acid degradation bifunctional protein TTL isoform X1 [Cucurbita pepo subsp. pepo]

1.7e-74

86.86

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Query:  MAASYDFGEEEFQACCGSSKFAREMVSVSPFFSLEQAMQLDASGLMVSVSPFFSLEQAVDAARRIWFNQVDVNGWLEAFSAHPQIGQASKSSNQTSAQWS
        MAASYDFGEEEFQACCGSSKFARE                     MVSVSPFFSLEQAVDAARRIWFNQVDVNGWLEAFSAHPQIGQASKSSNQTSAQWS
Subjt:  MAASYDFGEEEFQACCGSSKFAREMVSVSPFFSLEQAMQLDASGLMVSVSPFFSLEQAVDAARRIWFNQVDVNGWLEAFSAHPQIGQASKSSNQTSAQWS

Query:  KGEQSTALATATGSSLQELAEWNIQYQKKFGFIFLICASGRSTDEILAELKKRYSNRPIVEFEIAAQEQMKITEL
        KGEQSTALATATGSSLQELAEWNIQYQKKFGFIFLICASGRSTD+ILAELKKRYSNRPI+EFEIAAQEQMKITEL
Subjt:  KGEQSTALATATGSSLQELAEWNIQYQKKFGFIFLICASGRSTDEILAELKKRYSNRPIVEFEIAAQEQMKITEL

XP_023540278.1 uric acid degradation bifunctional protein TTL isoform X2 [Cucurbita pepo subsp. pepo]

1.7e-74

86.86

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Query:  MAASYDFGEEEFQACCGSSKFAREMVSVSPFFSLEQAMQLDASGLMVSVSPFFSLEQAVDAARRIWFNQVDVNGWLEAFSAHPQIGQASKSSNQTSAQWS
        MAASYDFGEEEFQACCGSSKFARE                     MVSVSPFFSLEQAVDAARRIWFNQVDVNGWLEAFSAHPQIGQASKSSNQTSAQWS
Subjt:  MAASYDFGEEEFQACCGSSKFAREMVSVSPFFSLEQAMQLDASGLMVSVSPFFSLEQAVDAARRIWFNQVDVNGWLEAFSAHPQIGQASKSSNQTSAQWS

Query:  KGEQSTALATATGSSLQELAEWNIQYQKKFGFIFLICASGRSTDEILAELKKRYSNRPIVEFEIAAQEQMKITEL
        KGEQSTALATATGSSLQELAEWNIQYQKKFGFIFLICASGRSTD+ILAELKKRYSNRPI+EFEIAAQEQMKITEL
Subjt:  KGEQSTALATATGSSLQELAEWNIQYQKKFGFIFLICASGRSTDEILAELKKRYSNRPIVEFEIAAQEQMKITEL

TrEMBL top hits

e value

%identity

Alignment

A0A1S3AWH8 Hydroxyisourate hydrolase

2.5e-66

78.41

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Query:  MAASYDFGEEEFQACCGSSKFAREMVSVSPFFSLEQAMQLDASGLMVSVSPFFSLEQAVDAARRIWFNQVDVNGWLEAFSAHPQI-GQASKSSNQTSAQW
        MA++YDFGEEEFQACCGSSKFA+E                     MVS SPF SLEQA+ AAR IWFNQVDV+GWLEAFSAHP+I GQ SKSSNQTSAQW
Subjt:  MAASYDFGEEEFQACCGSSKFAREMVSVSPFFSLEQAMQLDASGLMVSVSPFFSLEQAVDAARRIWFNQVDVNGWLEAFSAHPQI-GQASKSSNQTSAQW

Query:  SKGEQSTALATATGSSLQELAEWNIQYQKKFGFIFLICASGRSTDEILAELKKRYSNRPIVEFEIAAQEQMKITEL
        SKGEQSTA+ATATGSSLQELAEWNIQYQ+KFGF+FLICASGRST EILAELKKRY NRPIVEFEIAAQEQMKITEL
Subjt:  SKGEQSTALATATGSSLQELAEWNIQYQKKFGFIFLICASGRSTDEILAELKKRYSNRPIVEFEIAAQEQMKITEL

A0A5D3D0I5 Uric acid degradation bifunctional protein TTL isoform X1

2.5e-66

78.41

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Query:  MAASYDFGEEEFQACCGSSKFAREMVSVSPFFSLEQAMQLDASGLMVSVSPFFSLEQAVDAARRIWFNQVDVNGWLEAFSAHPQI-GQASKSSNQTSAQW
        MA++YDFGEEEFQACCGSSKFA+E                     MVS SPF SLEQA+ AAR IWFNQVDV+GWLEAFSAHP+I GQ SKSSNQTSAQW
Subjt:  MAASYDFGEEEFQACCGSSKFAREMVSVSPFFSLEQAMQLDASGLMVSVSPFFSLEQAVDAARRIWFNQVDVNGWLEAFSAHPQI-GQASKSSNQTSAQW

Query:  SKGEQSTALATATGSSLQELAEWNIQYQKKFGFIFLICASGRSTDEILAELKKRYSNRPIVEFEIAAQEQMKITEL
        SKGEQSTA+ATATGSSLQELAEWNIQYQ+KFGF+FLICASGRST EILAELKKRY NRPIVEFEIAAQEQMKITEL
Subjt:  SKGEQSTALATATGSSLQELAEWNIQYQKKFGFIFLICASGRSTDEILAELKKRYSNRPIVEFEIAAQEQMKITEL

A0A6J1G360 Hydroxyisourate hydrolase

2.2e-75

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Query:  MAASYDFGEEEFQACCGSSKFAREMVSVSPFFSLEQAMQLDASGLMVSVSPFFSLEQAVDAARRIWFNQVDVNGWLEAFSAHPQIGQASKSSNQTSAQWS
        MAASYDFGEEEFQACCGSSKFARE                     MVSVSPFFSLEQAVDAARRIWFNQVDVNGWLEAFSAHPQIGQASKSSNQTSAQWS
Subjt:  MAASYDFGEEEFQACCGSSKFAREMVSVSPFFSLEQAMQLDASGLMVSVSPFFSLEQAVDAARRIWFNQVDVNGWLEAFSAHPQIGQASKSSNQTSAQWS

Query:  KGEQSTALATATGSSLQELAEWNIQYQKKFGFIFLICASGRSTDEILAELKKRYSNRPIVEFEIAAQEQMKITEL
        KGEQSTALATATGSSLQELAEWNIQYQKKFGFIFLICASGRSTDEILAELKKRYSNRPIVEFEIAAQEQMKITEL
Subjt:  KGEQSTALATATGSSLQELAEWNIQYQKKFGFIFLICASGRSTDEILAELKKRYSNRPIVEFEIAAQEQMKITEL

A0A6J1G375 Hydroxyisourate hydrolase

2.2e-75

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Query:  MAASYDFGEEEFQACCGSSKFAREMVSVSPFFSLEQAMQLDASGLMVSVSPFFSLEQAVDAARRIWFNQVDVNGWLEAFSAHPQIGQASKSSNQTSAQWS
        MAASYDFGEEEFQACCGSSKFARE                     MVSVSPFFSLEQAVDAARRIWFNQVDVNGWLEAFSAHPQIGQASKSSNQTSAQWS
Subjt:  MAASYDFGEEEFQACCGSSKFAREMVSVSPFFSLEQAMQLDASGLMVSVSPFFSLEQAVDAARRIWFNQVDVNGWLEAFSAHPQIGQASKSSNQTSAQWS

Query:  KGEQSTALATATGSSLQELAEWNIQYQKKFGFIFLICASGRSTDEILAELKKRYSNRPIVEFEIAAQEQMKITEL
        KGEQSTALATATGSSLQELAEWNIQYQKKFGFIFLICASGRSTDEILAELKKRYSNRPIVEFEIAAQEQMKITEL
Subjt:  KGEQSTALATATGSSLQELAEWNIQYQKKFGFIFLICASGRSTDEILAELKKRYSNRPIVEFEIAAQEQMKITEL

A0A6J1IBP9 uric acid degradation bifunctional protein TTL-like

2.2e-75

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Query:  MAASYDFGEEEFQACCGSSKFAREMVSVSPFFSLEQAMQLDASGLMVSVSPFFSLEQAVDAARRIWFNQVDVNGWLEAFSAHPQIGQASKSSNQTSAQWS
        MAASYDFGEEEFQACCGSSKFARE                     MVSVSPFFSLEQAVDAARRIWFNQVDVNGWLEAFSAHPQIGQASKSSNQTSAQWS
Subjt:  MAASYDFGEEEFQACCGSSKFAREMVSVSPFFSLEQAMQLDASGLMVSVSPFFSLEQAVDAARRIWFNQVDVNGWLEAFSAHPQIGQASKSSNQTSAQWS

Query:  KGEQSTALATATGSSLQELAEWNIQYQKKFGFIFLICASGRSTDEILAELKKRYSNRPIVEFEIAAQEQMKITEL
        KGEQSTALATATGSSLQELAEWNIQYQKKFGFIFLICASGRSTDEILAELKKRYSNRPIVEFEIAAQEQMKITEL
Subjt:  KGEQSTALATATGSSLQELAEWNIQYQKKFGFIFLICASGRSTDEILAELKKRYSNRPIVEFEIAAQEQMKITEL

SwissProt top hits

e value

%identity

Alignment

Q54SV3 Probable allantoinase 1

9.4e-07

31.3

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Query:  MVSVSPFFSLEQAVDAARRIWFNQVDVNGWLEAFSAHPQIGQASKSSNQTSAQWSKGEQSTALATATGSS-LQELAEWNIQYQKKFGFIFLICASGRSTD
        + S  PF S +Q +D A  I    ++ +  ++  +AHP+IG  S S  + S+  S  EQS    ++   S L+ L + N QY+ KFGF F++  +GR  +
Subjt:  MVSVSPFFSLEQAVDAARRIWFNQVDVNGWLEAFSAHPQIGQASKSSNQTSAQWSKGEQSTALATATGSS-LQELAEWNIQYQKKFGFIFLICASGRSTD

Query:  EILAELKKRYSNR-PIVEFEIAAQEQMKITE
        EI+  L+ R +N     E  +   E ++I++
Subjt:  EILAELKKRYSNR-PIVEFEIAAQEQMKITE

Q9LVM5 Uric acid degradation bifunctional protein TTL

6.9e-42

54.97

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Query:  DFGEEEFQACCGSSKFAREMVSVSPFFSLEQAMQLDASGLMVSVSPFFSLEQAVDAARRIWFNQVDVNGWLEAFSAHPQIGQA-SKSSNQTSAQWSKGEQ
        + GE+E++ CCGSS+FA++M +  P  S                      ++A+  AR IWFNQV+V  WLEAFSAHPQIG   S S N   A+ S  EQ
Subjt:  DFGEEEFQACCGSSKFAREMVSVSPFFSLEQAMQLDASGLMVSVSPFFSLEQAVDAARRIWFNQVDVNGWLEAFSAHPQIGQA-SKSSNQTSAQWSKGEQ

Query:  STALATATGSSLQELAEWNIQYQKKFGFIFLICASGRSTDEILAELKKRYSNRPIVEFEIAAQEQMKITEL
        STA AT + S+LQELAEWN+ Y+KKFGFIF+ICASGR+  E+L  LK+RY NRPIVE EIAA EQMKITEL
Subjt:  STALATATGSSLQELAEWNIQYQKKFGFIFLICASGRSTDEILAELKKRYSNRPIVEFEIAAQEQMKITEL

Arabidopsis top hits

e value

%identity

Alignment

AT5G58220.1 transthyretin-like protein

4.9e-43

54.97

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Query:  DFGEEEFQACCGSSKFAREMVSVSPFFSLEQAMQLDASGLMVSVSPFFSLEQAVDAARRIWFNQVDVNGWLEAFSAHPQIGQA-SKSSNQTSAQWSKGEQ
        + GE+E++ CCGSS+FA++M +  P  S                      ++A+  AR IWFNQV+V  WLEAFSAHPQIG   S S N   A+ S  EQ
Subjt:  DFGEEEFQACCGSSKFAREMVSVSPFFSLEQAMQLDASGLMVSVSPFFSLEQAVDAARRIWFNQVDVNGWLEAFSAHPQIGQA-SKSSNQTSAQWSKGEQ

Query:  STALATATGSSLQELAEWNIQYQKKFGFIFLICASGRSTDEILAELKKRYSNRPIVEFEIAAQEQMKITEL
        STA AT + S+LQELAEWN+ Y+KKFGFIF+ICASGR+  E+L  LK+RY NRPIVE EIAA EQMKITEL
Subjt:  STALATATGSSLQELAEWNIQYQKKFGFIFLICASGRSTDEILAELKKRYSNRPIVEFEIAAQEQMKITEL

AT5G58220.2 transthyretin-like protein

4.9e-43

54.97

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Query:  DFGEEEFQACCGSSKFAREMVSVSPFFSLEQAMQLDASGLMVSVSPFFSLEQAVDAARRIWFNQVDVNGWLEAFSAHPQIGQA-SKSSNQTSAQWSKGEQ
        + GE+E++ CCGSS+FA++M +  P  S                      ++A+  AR IWFNQV+V  WLEAFSAHPQIG   S S N   A+ S  EQ
Subjt:  DFGEEEFQACCGSSKFAREMVSVSPFFSLEQAMQLDASGLMVSVSPFFSLEQAVDAARRIWFNQVDVNGWLEAFSAHPQIGQA-SKSSNQTSAQWSKGEQ

Query:  STALATATGSSLQELAEWNIQYQKKFGFIFLICASGRSTDEILAELKKRYSNRPIVEFEIAAQEQMKITEL
        STA AT + S+LQELAEWN+ Y+KKFGFIF+ICASGR+  E+L  LK+RY NRPIVE EIAA EQMKITEL
Subjt:  STALATATGSSLQELAEWNIQYQKKFGFIFLICASGRSTDEILAELKKRYSNRPIVEFEIAAQEQMKITEL

AT5G58220.3 transthyretin-like protein

4.9e-43

54.97

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Query:  DFGEEEFQACCGSSKFAREMVSVSPFFSLEQAMQLDASGLMVSVSPFFSLEQAVDAARRIWFNQVDVNGWLEAFSAHPQIGQA-SKSSNQTSAQWSKGEQ
        + GE+E++ CCGSS+FA++M +  P  S                      ++A+  AR IWFNQV+V  WLEAFSAHPQIG   S S N   A+ S  EQ
Subjt:  DFGEEEFQACCGSSKFAREMVSVSPFFSLEQAMQLDASGLMVSVSPFFSLEQAVDAARRIWFNQVDVNGWLEAFSAHPQIGQA-SKSSNQTSAQWSKGEQ

Query:  STALATATGSSLQELAEWNIQYQKKFGFIFLICASGRSTDEILAELKKRYSNRPIVEFEIAAQEQMKITEL
        STA AT + S+LQELAEWN+ Y+KKFGFIF+ICASGR+  E+L  LK+RY NRPIVE EIAA EQMKITEL
Subjt:  STALATATGSSLQELAEWNIQYQKKFGFIFLICASGRSTDEILAELKKRYSNRPIVEFEIAAQEQMKITEL

Sequences

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CDS sequence

Show/hide CDS sequence

ATGGCGGCGAGTTATGATTTTGGAGAGGAAGAGTTTCAGGCATGCTGTGGAAGCTCCAAATTCGCCAGAGAAATGGTTTCCGTTTCCCCTTTTTTCTCCTTGGAA
CAAGCTATGCAGCTAGACGCATCTGGTTTAATGGTTTCCGTTTCCCCTTTTTTCTCCTTGGAACAAGCTGTAGATGCAGCTAGACGCATCTGGTTTAATCAGGTC
GATGTGAATGGTTGGCTGGAAGCATTCTCTGCTCATCCACAGATTGGTCAAGCCTCCAAATCATCCAATCAGACGAGTGCTCAATGGAGTAAGGGAGAGCAGTCA
ACTGCACTGGCAACTGCTACTGGTTCTAGCTTACAGGAGCTAGCTGAATGGAATATTCAGTACCAGAAAAAGTTTGGATTTATATTTCTTATTTGTGCATCTGGA
AGGAGCACCGACGAAATACTTGCAGAATTAAAGAAACGGTATTCAAATAGACCCATAGTTGAGTTTGAGATTGCTGCTCAAGAGCAAATGAAAATAACAGAACTG

mRNA sequence

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Protein sequence

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MAASYDFGEEEFQACCGSSKFAREMVSVSPFFSLEQAMQLDASGLMVSVSPFFSLEQAVDAARRIWFNQVDVNGWLEAFSAHPQIGQASKSSNQTSAQWSKGEQS
TALATATGSSLQELAEWNIQYQKKFGFIFLICASGRSTDEILAELKKRYSNRPIVEFEIAAQEQMKITEL

CmaCh06G012080 (gene) of Cucurbita maxima (Rimu) v1.1 genome