; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; CuGenDBv2

CmaCh14G009140 (gene) of Cucurbita maxima (Rimu) v1.1 genome

Gene IDCmaCh14G009140
OrganismCucurbita maxima Rimu (Cucurbita maxima (Rimu) v1.1)
Descriptionpectinesterase inhibitor-like
Genome locationCma_Chr14:4742703..4744713
RNA-Seq ExpressionCmaCh14G009140
SyntenyCmaCh14G009140
Gene Ontology termsGO:0043086 - negative regulation of catalytic activity (biological process)
GO:0030599 - pectinesterase activity (molecular function)
GO:0046910 - pectinesterase inhibitor activity (molecular function)
InterPro domainsIPR006501 - Pectinesterase inhibitor domain
IPR035513 - Invertase/pectin methylesterase inhibitor domain superfamily


Homology Show/hide homology
GenBank top hitse value%identityAlignment
KAG6581280.1 Pectinesterase inhibitor, partial [Cucurbita argyrosperma subsp. sororia]2.6e-8996.63Show/hide
Query:  MKFISAIVVILCLCMATKRHDATRPVEEGMTLIEEMCSQTKHKELCVDSLTSDPNSYPADKTGLALVALRFASSNASDISESIKVMFNDSTLSKPMVQEA
        MKFISAIVV+LCLCMA KRHDATRPVEEGM LIEEMCSQTKHKELCVDSLTSDPNSYPADKTGLALVALRFASSNASDISESIKVMFNDSTLSKPMVQEA
Subjt:  MKFISAIVVILCLCMATKRHDATRPVEEGMTLIEEMCSQTKHKELCVDSLTSDPNSYPADKTGLALVALRFASSNASDISESIKVMFNDSTLSKPMVQEA

Query:  LLDCLDEYLDASQQLDDSIAALTVKAYGDLEKWVNIAMTDVRTCGTELGSERPPLLTERNDVFIKLCEIALTISKIAQ
        LLDCLDEYLDASQQLDDSIAALTVKAYGDLEKWVNIA+TDVRTCGTELG ERPPLLTERN+VFIKLCEIALTISKIAQ
Subjt:  LLDCLDEYLDASQQLDDSIAALTVKAYGDLEKWVNIAMTDVRTCGTELGSERPPLLTERNDVFIKLCEIALTISKIAQ

XP_022934353.1 pectinesterase inhibitor-like [Cucurbita moschata]8.8e-9096.63Show/hide
Query:  MKFISAIVVILCLCMATKRHDATRPVEEGMTLIEEMCSQTKHKELCVDSLTSDPNSYPADKTGLALVALRFASSNASDISESIKVMFNDSTLSKPMVQEA
        MKF+SAIVV+LCLCMA KRHDATRPVEEGM LIEEMCSQTKHKELCVDSLTSDPNSYPADKTGLALVALRFASSNASDISESIKVMFNDSTLSKPMVQEA
Subjt:  MKFISAIVVILCLCMATKRHDATRPVEEGMTLIEEMCSQTKHKELCVDSLTSDPNSYPADKTGLALVALRFASSNASDISESIKVMFNDSTLSKPMVQEA

Query:  LLDCLDEYLDASQQLDDSIAALTVKAYGDLEKWVNIAMTDVRTCGTELGSERPPLLTERNDVFIKLCEIALTISKIAQ
        LLDCLDEYLDASQQLDDSIAALTVKAYGDLEKWVNIA+TDVRTCGTELGSERPPLLTERN+VFIKLCEIALTISKIAQ
Subjt:  LLDCLDEYLDASQQLDDSIAALTVKAYGDLEKWVNIAMTDVRTCGTELGSERPPLLTERNDVFIKLCEIALTISKIAQ

XP_022984074.1 pectinesterase inhibitor-like [Cucurbita maxima]4.2e-92100Show/hide
Query:  MKFISAIVVILCLCMATKRHDATRPVEEGMTLIEEMCSQTKHKELCVDSLTSDPNSYPADKTGLALVALRFASSNASDISESIKVMFNDSTLSKPMVQEA
        MKFISAIVVILCLCMATKRHDATRPVEEGMTLIEEMCSQTKHKELCVDSLTSDPNSYPADKTGLALVALRFASSNASDISESIKVMFNDSTLSKPMVQEA
Subjt:  MKFISAIVVILCLCMATKRHDATRPVEEGMTLIEEMCSQTKHKELCVDSLTSDPNSYPADKTGLALVALRFASSNASDISESIKVMFNDSTLSKPMVQEA

Query:  LLDCLDEYLDASQQLDDSIAALTVKAYGDLEKWVNIAMTDVRTCGTELGSERPPLLTERNDVFIKLCEIALTISKIAQ
        LLDCLDEYLDASQQLDDSIAALTVKAYGDLEKWVNIAMTDVRTCGTELGSERPPLLTERNDVFIKLCEIALTISKIAQ
Subjt:  LLDCLDEYLDASQQLDDSIAALTVKAYGDLEKWVNIAMTDVRTCGTELGSERPPLLTERNDVFIKLCEIALTISKIAQ

XP_023528768.1 pectinesterase inhibitor-like [Cucurbita pepo subsp. pepo]8.2e-8897.69Show/hide
Query:  AIVVILCLCMATKRHDATRPVEEGMTLIEEMCSQTKHKELCVDSLTSDPNSYPADKTGLALVALRFASSNASDISESIKVMFNDSTLSKPMVQEALLDCL
        AIVV+LCLCMA KRHDATRPVEEGM LIEEMCSQTKHKELCVDSLTSDPNSYPADKTGLALVALRFASSNASDISESIKVMFNDSTL+KPMVQEALLDCL
Subjt:  AIVVILCLCMATKRHDATRPVEEGMTLIEEMCSQTKHKELCVDSLTSDPNSYPADKTGLALVALRFASSNASDISESIKVMFNDSTLSKPMVQEALLDCL

Query:  DEYLDASQQLDDSIAALTVKAYGDLEKWVNIAMTDVRTCGTELGSERPPLLTERNDVFIKLCEIALTISKIAQ
        DEYLDASQQLDDSIAALTVKAYGDLEKWVNIAMTDVRTCGTELGSERPPLLTERNDVFIKLCEIALTISKIAQ
Subjt:  DEYLDASQQLDDSIAALTVKAYGDLEKWVNIAMTDVRTCGTELGSERPPLLTERNDVFIKLCEIALTISKIAQ

XP_038906317.1 cell wall / vacuolar inhibitor of fructosidase 2-like [Benincasa hispida]2.3e-6168.93Show/hide
Query:  MKFISAIVVILCLCMATKRHDATRPVEEGMTLIEEMCSQTKHKELCVDSLTSDPNSYPADKTGLALVALRFASSNASDISESIKVMFNDSTLSKPMVQEA
        MKF+SAI+ +LCL M  +R DA  P E+G+++I+ MC+QT +K+LCV SLTSDPNS+PADK GLALVALRFASSNASDISESIKVM ND++L+KP VQ+ 
Subjt:  MKFISAIVVILCLCMATKRHDATRPVEEGMTLIEEMCSQTKHKELCVDSLTSDPNSYPADKTGLALVALRFASSNASDISESIKVMFNDSTLSKPMVQEA

Query:  LLDCLDEYLDASQQLDDSIAALTVKAYGDLEKWVNIAMTDVRTCGTELGSERPPLLTERNDVFIKLCEIALTISKIA
        L DCLDEYLDASQQLDD+IAA+ VKAYGD+EKWV+ A+  VRTC  E  + +P LL  +NDVFIKLCEIAL+ISK+A
Subjt:  LLDCLDEYLDASQQLDDSIAALTVKAYGDLEKWVNIAMTDVRTCGTELGSERPPLLTERNDVFIKLCEIALTISKIA

TrEMBL top hitse value%identityAlignment
A0A0A0KY96 PMEI domain-containing protein1.2e-5564.44Show/hide
Query:  MKFISAIVVILCLCMATKRHDATRPV-EEGMTLIEEMCSQTKHKELCVDSLTSDPNSYPADKTGLALVALRFASSNASDISESIKVMFND-STLSKPMVQ
        MKF SAI+++LCLCMA +R DA     EEG+ +I++MC+QT +K+LC+ SLTSDPNS+PADK GLALVALR ASSNASDISESIKVM N+ S  ++P VQ
Subjt:  MKFISAIVVILCLCMATKRHDATRPV-EEGMTLIEEMCSQTKHKELCVDSLTSDPNSYPADKTGLALVALRFASSNASDISESIKVMFND-STLSKPMVQ

Query:  EALLDCLDEYLDASQQLDDSIAALTVKAYGDLEKWVNIAMTDVRTCGTELGSERPPLLTERNDVFIKLCEIALTISKIAQ
        +AL DCLDEYL+ASQQLDDSIAA+  KAYGD+++WV +A+T+VRTC +   + +P +LT RN+ FIKLC+IAL+I+KIA+
Subjt:  EALLDCLDEYLDASQQLDDSIAALTVKAYGDLEKWVNIAMTDVRTCGTELGSERPPLLTERNDVFIKLCEIALTISKIAQ

A0A5D3E196 Putative invertase inhibitor6.6e-5165.45Show/hide
Query:  MATKRHD-ATRPVEEGMTLIEEMCSQTKHKELCVDSLTSDPNSYPADKTGLALVALRFASSNASDISESIKVMFNDSTLSKPMVQEALLDCLDEYLDASQ
        MA +R D A++  +EG+  IE+MC+QT +K+LCV SLTSDPNS+PADK GLALVALR ASSNASDISESIKVM N+++ ++P VQ+ L DCLDEYLDASQ
Subjt:  MATKRHD-ATRPVEEGMTLIEEMCSQTKHKELCVDSLTSDPNSYPADKTGLALVALRFASSNASDISESIKVMFNDSTLSKPMVQEALLDCLDEYLDASQ

Query:  QLDDSIAALTVKAYGDLEKWVNIAMTDVRTCGTELGSERPPLLTERNDVFIKLCEIALTISKIAQ
        QLDDSIAA+  KAYGD+EKWV+ A+ DVRTC     + +P +LT RN+ FIKLC+IAL+IS+IA+
Subjt:  QLDDSIAALTVKAYGDLEKWVNIAMTDVRTCGTELGSERPPLLTERNDVFIKLCEIALTISKIAQ

A0A6J1DPW6 pectinesterase inhibitor-like2.4e-4863.79Show/hide
Query:  AIVVILCLCMATKRHDATRPVEEGMTLIEEMCSQTKHKELCVDSLTSDPNSYPADKTGLALVALRFASSNASDISESIKVMFNDSTLS-KPMVQEALLDC
        A++V++ L +A    +A RP +  M LIE+ CSQT+H  LC+ SL SDPNS+PADKTGLALVALR  SSNASDISE IKVM ND+ L+ +P VQ+ L DC
Subjt:  AIVVILCLCMATKRHDATRPVEEGMTLIEEMCSQTKHKELCVDSLTSDPNSYPADKTGLALVALRFASSNASDISESIKVMFNDSTLS-KPMVQEALLDC

Query:  LDEYLDASQQLDDSIAALTVKAYGDLEKWVNIAMTDVRTCGTELGSERPPLLTERNDVFIKLCEIALTISKIAQ
        LDEYLDASQQLDDSIAAL VKAYGD++KWVN A+  VRTC     S +P +LT RND FIKLC+ ALTI+ IA+
Subjt:  LDEYLDASQQLDDSIAALTVKAYGDLEKWVNIAMTDVRTCGTELGSERPPLLTERNDVFIKLCEIALTISKIAQ

A0A6J1F7F2 pectinesterase inhibitor-like4.3e-9096.63Show/hide
Query:  MKFISAIVVILCLCMATKRHDATRPVEEGMTLIEEMCSQTKHKELCVDSLTSDPNSYPADKTGLALVALRFASSNASDISESIKVMFNDSTLSKPMVQEA
        MKF+SAIVV+LCLCMA KRHDATRPVEEGM LIEEMCSQTKHKELCVDSLTSDPNSYPADKTGLALVALRFASSNASDISESIKVMFNDSTLSKPMVQEA
Subjt:  MKFISAIVVILCLCMATKRHDATRPVEEGMTLIEEMCSQTKHKELCVDSLTSDPNSYPADKTGLALVALRFASSNASDISESIKVMFNDSTLSKPMVQEA

Query:  LLDCLDEYLDASQQLDDSIAALTVKAYGDLEKWVNIAMTDVRTCGTELGSERPPLLTERNDVFIKLCEIALTISKIAQ
        LLDCLDEYLDASQQLDDSIAALTVKAYGDLEKWVNIA+TDVRTCGTELGSERPPLLTERN+VFIKLCEIALTISKIAQ
Subjt:  LLDCLDEYLDASQQLDDSIAALTVKAYGDLEKWVNIAMTDVRTCGTELGSERPPLLTERNDVFIKLCEIALTISKIAQ

A0A6J1J9E7 pectinesterase inhibitor-like2.0e-92100Show/hide
Query:  MKFISAIVVILCLCMATKRHDATRPVEEGMTLIEEMCSQTKHKELCVDSLTSDPNSYPADKTGLALVALRFASSNASDISESIKVMFNDSTLSKPMVQEA
        MKFISAIVVILCLCMATKRHDATRPVEEGMTLIEEMCSQTKHKELCVDSLTSDPNSYPADKTGLALVALRFASSNASDISESIKVMFNDSTLSKPMVQEA
Subjt:  MKFISAIVVILCLCMATKRHDATRPVEEGMTLIEEMCSQTKHKELCVDSLTSDPNSYPADKTGLALVALRFASSNASDISESIKVMFNDSTLSKPMVQEA

Query:  LLDCLDEYLDASQQLDDSIAALTVKAYGDLEKWVNIAMTDVRTCGTELGSERPPLLTERNDVFIKLCEIALTISKIAQ
        LLDCLDEYLDASQQLDDSIAALTVKAYGDLEKWVNIAMTDVRTCGTELGSERPPLLTERNDVFIKLCEIALTISKIAQ
Subjt:  LLDCLDEYLDASQQLDDSIAALTVKAYGDLEKWVNIAMTDVRTCGTELGSERPPLLTERNDVFIKLCEIALTISKIAQ

SwissProt top hitse value%identityAlignment
Q0J8J8 Pectinesterase inhibitor 281.9e-0724.56Show/hide
Query:  EGMTLIEEMCSQTKHKELCVDSLTSDPNSYPADKTGLALVALRFASSNASDISESIKVMFND------STLSKPMVQEALLDCLDEYLDASQQLDDSIAA
        +   L+   C+ T + ++CV +L +DP+S  AD  GL+ +A+  A++NAS  +++   + N       +      VQ  L  C  +Y DA   L  +  +
Subjt:  EGMTLIEEMCSQTKHKELCVDSLTSDPNSYPADKTGLALVALRFASSNASDISESIKVMFND------STLSKPMVQEALLDCLDEYLDASQQLDDSIAA

Query:  LTVKAYGDLEKWVNIAMTDVRTCGTELGSERPPL----LTERNDVFIKLCEIALTISKIAQAPTPSSSDSS
        +  + Y      V+      + C      +RP      L  R +   KLC +AL I  +  +   S++++S
Subjt:  LTVKAYGDLEKWVNIAMTDVRTCGTELGSERPPL----LTERNDVFIKLCEIALTISKIAQAPTPSSSDSS

Arabidopsis top hitse value%identityAlignment
AT1G53840.1 pectin methylesterase 12.1e-0424.68Show/hide
Query:  IVVILCLCMATKRH-------DATRPVEEGMTLIEEMCSQTKHKELCVDSLTSDPNSYPADKTGLALVALRFASSNASDISESIKVMFNDSTLSKPMVQE
        I VI+   +AT  H        +  P     T ++ +CS T+  E C+ S++  P+S   D   L  ++L+        IS+  + +  ++      ++ 
Subjt:  IVVILCLCMATKRH-------DATRPVEEGMTLIEEMCSQTKHKELCVDSLTSDPNSYPADKTGLALVALRFASSNASDISESIKVMFNDSTLSKPMVQE

Query:  ALLDCLDEYLDASQQLDDSIAA---------LTVKAYGDLEKWVNIAMTDVRTC
        AL  C D   DA  +L+D+++A         L+     DL+ W++  +TD  TC
Subjt:  ALLDCLDEYLDASQQLDDSIAA---------LTVKAYGDLEKWVNIAMTDVRTC

AT1G55770.1 Plant invertase/pectin methylesterase inhibitor superfamily protein3.7e-2235.23Show/hide
Query:  SAIVVILCLCMATKRHDATRPVEEGMTLIEEMCSQTKHKELCVDSLTSDPNS--YPADKTGLALVALRFASSNASDISESIKVMFNDSTLSKPMVQEALL
        SA V+ LC+ + +     T     GM  I ++C  +    LC+ S+TS P S  +      + ++A+  AS+NAS  S  IK   ++  L +P +++ L 
Subjt:  SAIVVILCLCMATKRHDATRPVEEGMTLIEEMCSQTKHKELCVDSLTSDPNS--YPADKTGLALVALRFASSNASDISESIKVMFNDSTLSKPMVQEALL

Query:  DCLDEYLDASQQLDDSIAALTVKAYGDLEKWVNIAMTDVRTCGTELGSE--RPPLLTERNDVFIKLCEIALTISKI
        DC  +Y DA +QLDDSI+A+   A+ D++ W++ A++ + +CG+ LGS       L++RN+VF+KLC+ AL I+K+
Subjt:  DCLDEYLDASQQLDDSIAALTVKAYGDLEKWVNIAMTDVRTCGTELGSE--RPPLLTERNDVFIKLCEIALTISKI

AT4G02250.1 Plant invertase/pectin methylesterase inhibitor superfamily protein2.5e-1841.18Show/hide
Query:  KELCVDSLTSDPNSYPADKTGLALVALRFASSNASDISESIKVMFNDSTLSKPMVQEALLDCLDEYLDASQQLDDSIAALTVKAYGDLEKWVNIAMTDVR
        K  CV SLTS P +  A    L ++AL  ASSNASD S  IK       L +P +++ L DC   YLDA  QLDDS+AAL   ++ D++ W+N A++D  
Subjt:  KELCVDSLTSDPNSYPADKTGLALVALRFASSNASDISESIKVMFNDSTLSKPMVQEALLDCLDEYLDASQQLDDSIAALTVKAYGDLEKWVNIAMTDVR

Query:  TCGTELGSE--RPPLLTERNDVFIKLCEIALTISKI
         C   L         L  RN   +KLC+ AL I+ I
Subjt:  TCGTELGSE--RPPLLTERNDVFIKLCEIALTISKI

AT5G46930.1 Plant invertase/pectin methylesterase inhibitor superfamily protein9.3e-0529.26Show/hide
Query:  MKFISAIVVILCL--CMATKRHDATRPVEEGMTLIEEMCSQTKHK------ELCVDSLTSDPNSYPADKTGLALVALRFASS-NASDISESIKVMFNDST
        MKF   +V+   L  C AT             +LI + C +   K      + CV SL  +P S    KT  +L  L F S+ NA   + S+K M  D  
Subjt:  MKFISAIVVILCL--CMATKRHDATRPVEEGMTLIEEMCSQTKHK------ELCVDSLTSDPNSYPADKTGLALVALRFASS-NASDISESIKVMFNDST

Query:  L--SKPMVQEALLDCLDEYLDASQQLDDSIAALTVKAYGDLEKWVNIAMTDVRTCGTELGSERPPL---LTERNDV--FIKLCEIALT
        L   K  V+  LLDCL+ Y +A   L+ S+  +  + Y      ++ AM    +C T+    +  +    T+ NDV  ++ L  IA T
Subjt:  L--SKPMVQEALLDCLDEYLDASQQLDDSIAALTVKAYGDLEKWVNIAMTDVRTCGTELGSERPPL---LTERNDV--FIKLCEIALT

AT5G46940.1 Plant invertase/pectin methylesterase inhibitor superfamily protein9.9e-0725.54Show/hide
Query:  MKFISAIVVILCLCMATKRHDATRPVEEGMTLIEEMCSQT-----KHK-ELCVDSLTSDPNSYPA-DKTGLALVALRFASSNASDISESIKVMFNDSTLS
        MKF+  +V    L         +  +  G TLI   C +      K K  LCV SL ++P +  A D  GL + + + A + A+ +  ++  +     ++
Subjt:  MKFISAIVVILCLCMATKRHDATRPVEEGMTLIEEMCSQT-----KHK-ELCVDSLTSDPNSYPA-DKTGLALVALRFASSNASDISESIKVMFNDSTLS

Query:  KPMVQEALLDCLDEYLDASQQLDDSIAALTVKAYGDLEKWVNIAMTDVRTCGTELGSERPPL-LTERNDVFIKLCEIALTISKI
        K M    L DCL  Y DA   L++++A +  + Y  ++  ++ AM    TC T     + P  +T+ ND   ++  I L  + +
Subjt:  KPMVQEALLDCLDEYLDASQQLDDSIAALTVKAYGDLEKWVNIAMTDVRTCGTELGSERPPL-LTERNDVFIKLCEIALTISKI


Sequences Show/hide sequences
CDS sequenceShow/hide CDS sequence
ATGAAATTTATCTCAGCCATTGTGGTAATTCTGTGCCTGTGCATGGCGACAAAGCGCCACGACGCCACCCGCCCCGTCGAGGAAGGGATGACCCTAATCGAGGAA
ATGTGTAGCCAAACCAAACACAAGGAGCTGTGCGTGGACTCCCTGACCTCGGACCCCAACAGCTACCCGGCCGACAAGACGGGGCTAGCCCTGGTGGCCCTCCGC
TTCGCCTCTTCCAACGCCTCGGACATCTCGGAGAGCATCAAGGTGATGTTCAATGACTCGACCCTGTCCAAGCCGATGGTGCAGGAGGCTCTCCTCGACTGCCTT
GACGAGTACCTAGACGCGTCCCAACAGCTGGACGACTCCATTGCAGCGCTGACGGTGAAGGCGTATGGGGACCTGGAGAAATGGGTGAATATAGCCATGACGGAT
GTGCGCACGTGTGGGACGGAGTTGGGCAGCGAGCGCCCACCGCTGCTGACGGAGAGGAATGATGTGTTTATTAAGCTGTGTGAAATTGCGCTGACCATTTCCAAG
ATTGCGCAGGCTCCGACACCCTCTTCTTCTGATTCCTCTGCGTTGCGATTTCTTTTTGTTATTGAGATTTCGCCAGTGGCCGCCTCGATTCTGAGTTTCTGTTCC
GCTTTCCTTCCACCACGGGAGTGGTTGTTTAATTTAATGCTAGTTGGATTCAATGAGATTTTCCTCTCCCACTAG
mRNA sequenceShow/hide mRNA sequence
ATGAAATTTATCTCAGCCATTGTGGTAATTCTGTGCCTGTGCATGGCGACAAAGCGCCACGACGCCACCCGCCCCGTCGAGGAAGGGATGACCCTAATCGAGGAA
ATGTGTAGCCAAACCAAACACAAGGAGCTGTGCGTGGACTCCCTGACCTCGGACCCCAACAGCTACCCGGCCGACAAGACGGGGCTAGCCCTGGTGGCCCTCCGC
TTCGCCTCTTCCAACGCCTCGGACATCTCGGAGAGCATCAAGGTGATGTTCAATGACTCGACCCTGTCCAAGCCGATGGTGCAGGAGGCTCTCCTCGACTGCCTT
GACGAGTACCTAGACGCGTCCCAACAGCTGGACGACTCCATTGCAGCGCTGACGGTGAAGGCGTATGGGGACCTGGAGAAATGGGTGAATATAGCCATGACGGAT
GTGCGCACGTGTGGGACGGAGTTGGGCAGCGAGCGCCCACCGCTGCTGACGGAGAGGAATGATGTGTTTATTAAGCTGTGTGAAATTGCGCTGACCATTTCCAAG
ATTGCGCAGGCTCCGACACCCTCTTCTTCTGATTCCTCTGCGTTGCGATTTCTTTTTGTTATTGAGATTTCGCCAGTGGCCGCCTCGATTCTGAGTTTCTGTTCC
GCTTTCCTTCCACCACGGGAGTGGTTGTTTAATTTAATGCTAGTTGGATTCAATGAGATTTTCCTCTCCCACTAG
Protein sequenceShow/hide protein sequence
MKFISAIVVILCLCMATKRHDATRPVEEGMTLIEEMCSQTKHKELCVDSLTSDPNSYPADKTGLALVALRFASSNASDISESIKVMFNDSTLSKPMVQEALLDCL
DEYLDASQQLDDSIAALTVKAYGDLEKWVNIAMTDVRTCGTELGSERPPLLTERNDVFIKLCEIALTISKIAQAPTPSSSDSSALRFLFVIEISPVAASILSFCS
AFLPPREWLFNLMLVGFNEIFLSH