CuGenDBv2

Gene ID	Cmc09g0244201
Organism	Cucumis melo var. cantalupensis cv. Charmono (Melon (Charmono) v1.1)
Description	Transmembrane protein 70, mitochondrial
Genome location	CMiso1.1chr09:6969809..6973956
RNA-Seq Expression	Cmc09g0244201
Synteny	Cmc09g0244201
Gene Ontology terms	GO:0006811 - ion transport (biological process) GO:0033615 - mitochondrial proton-transporting ATP synthase complex assembly (biological process) GO:0016020 - membrane (cellular component)
InterPro domains	IPR009724 - TMEM70 family

Homology

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GenBank top hits

e value

%identity

Alignment

KAA0040634.1 uncharacterized protein E6C27_scaffold262G002230 [Cucumis melo var. makuwa]

3.2e-116

97.7

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Query:  SRRNYYSGYHLQRSTAWINEKFVPTSNFLSQKNAVQKRWASQAPTREDDGKISIGPERGSEEDEKDVAYIGPISSTIKKVKLLSLSTCCLSVSLGPVITF
        S+ ++ SGYHLQRSTAWINEKFVPTSNFLSQKNAVQKRWASQAPTREDDGKISIGPERGSEEDEKDVAYIGPISSTIKKVKLLSLSTCCLSVSLGPVITF
Subjt:  SRRNYYSGYHLQRSTAWINEKFVPTSNFLSQKNAVQKRWASQAPTREDDGKISIGPERGSEEDEKDVAYIGPISSTIKKVKLLSLSTCCLSVSLGPVITF

Query:  MTSPDMNVILKGVVASSVIFLSATTTGALHWFVSPYVHKIRWKPGSDSFEVEVMSWLATYIPRTIRFADIRPPETNRPFVTFKANGNFYFVDKEHCHNKA
        MTSPDMNVILKGVVASSVIFLSATTTGALHWFVSPYVHKIRWKPGSDSFEVEVMSWLATYIPRTIRFADIRPPETNRPFVTFKANGNFYFVDKEHCHNKA
Subjt:  MTSPDMNVILKGVVASSVIFLSATTTGALHWFVSPYVHKIRWKPGSDSFEVEVMSWLATYIPRTIRFADIRPPETNRPFVTFKANGNFYFVDKEHCHNKA

Query:  LLARLTPQQRESAFRNL
        LLARLTPQQRESAFRNL
Subjt:  LLARLTPQQRESAFRNL

KGN51656.2 hypothetical protein Csa_009117, partial [Cucumis sativus]

3.5e-123

96.61

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Query:  MTRAALFHLLRSQSKHISRRNYYSGYHLQRSTAWINEKFVPTSNFLSQKNAVQKRWASQAPTREDDGKISIGPERG--SEEDEKDVAYIGPISSTIKKVK
        MTRAALFHLLRSQSKHISRRNYYSGYHLQRSTAWINEKFVPTSNFLSQKNAVQKRWASQA TREDDGKISIGP RG  +EEDEKDVAYIGPISSTIKKVK
Subjt:  MTRAALFHLLRSQSKHISRRNYYSGYHLQRSTAWINEKFVPTSNFLSQKNAVQKRWASQAPTREDDGKISIGPERG--SEEDEKDVAYIGPISSTIKKVK

Query:  LLSLSTCCLSVSLGPVITFMTSPDMNVILKGVVASSVIFLSATTTGALHWFVSPYVHKIRWKPGSDSFEVEVMSWLATYIPRTIRFADIRPPETNRPFVT
        LLSLSTCCLSVSLGPVITFMTSPDMNVILKGVVASSVIFLSATTTGALHWFVSPYVHKIRWKPGSDSFEVEVMSWLATYIPRTIRFADIRPPETNRPFVT
Subjt:  LLSLSTCCLSVSLGPVITFMTSPDMNVILKGVVASSVIFLSATTTGALHWFVSPYVHKIRWKPGSDSFEVEVMSWLATYIPRTIRFADIRPPETNRPFVT

Query:  FKANGNFYFVDKEHCHNKALLARLTPQQRESAFRNL
        FKANG+FYFVDKEHC NKALLARLTPQQRESA RNL
Subjt:  FKANGNFYFVDKEHCHNKALLARLTPQQRESAFRNL

XP_004143808.1 uncharacterized protein LOC101213359 [Cucumis sativus]

3.5e-123

96.61

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Query:  MTRAALFHLLRSQSKHISRRNYYSGYHLQRSTAWINEKFVPTSNFLSQKNAVQKRWASQAPTREDDGKISIGPERG--SEEDEKDVAYIGPISSTIKKVK
        MTRAALFHLLRSQSKHISRRNYYSGYHLQRSTAWINEKFVPTSNFLSQKNAVQKRWASQA TREDDGKISIGP RG  +EEDEKDVAYIGPISSTIKKVK
Subjt:  MTRAALFHLLRSQSKHISRRNYYSGYHLQRSTAWINEKFVPTSNFLSQKNAVQKRWASQAPTREDDGKISIGPERG--SEEDEKDVAYIGPISSTIKKVK

Query:  LLSLSTCCLSVSLGPVITFMTSPDMNVILKGVVASSVIFLSATTTGALHWFVSPYVHKIRWKPGSDSFEVEVMSWLATYIPRTIRFADIRPPETNRPFVT
        LLSLSTCCLSVSLGPVITFMTSPDMNVILKGVVASSVIFLSATTTGALHWFVSPYVHKIRWKPGSDSFEVEVMSWLATYIPRTIRFADIRPPETNRPFVT
Subjt:  LLSLSTCCLSVSLGPVITFMTSPDMNVILKGVVASSVIFLSATTTGALHWFVSPYVHKIRWKPGSDSFEVEVMSWLATYIPRTIRFADIRPPETNRPFVT

Query:  FKANGNFYFVDKEHCHNKALLARLTPQQRESAFRNL
        FKANG+FYFVDKEHC NKALLARLTPQQRESA RNL
Subjt:  FKANGNFYFVDKEHCHNKALLARLTPQQRESAFRNL

XP_008465660.1 PREDICTED: uncharacterized protein LOC103503301 [Cucumis melo]

5.6e-129

100

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Query:  MTRAALFHLLRSQSKHISRRNYYSGYHLQRSTAWINEKFVPTSNFLSQKNAVQKRWASQAPTREDDGKISIGPERGSEEDEKDVAYIGPISSTIKKVKLL
        MTRAALFHLLRSQSKHISRRNYYSGYHLQRSTAWINEKFVPTSNFLSQKNAVQKRWASQAPTREDDGKISIGPERGSEEDEKDVAYIGPISSTIKKVKLL
Subjt:  MTRAALFHLLRSQSKHISRRNYYSGYHLQRSTAWINEKFVPTSNFLSQKNAVQKRWASQAPTREDDGKISIGPERGSEEDEKDVAYIGPISSTIKKVKLL

Query:  SLSTCCLSVSLGPVITFMTSPDMNVILKGVVASSVIFLSATTTGALHWFVSPYVHKIRWKPGSDSFEVEVMSWLATYIPRTIRFADIRPPETNRPFVTFK
        SLSTCCLSVSLGPVITFMTSPDMNVILKGVVASSVIFLSATTTGALHWFVSPYVHKIRWKPGSDSFEVEVMSWLATYIPRTIRFADIRPPETNRPFVTFK
Subjt:  SLSTCCLSVSLGPVITFMTSPDMNVILKGVVASSVIFLSATTTGALHWFVSPYVHKIRWKPGSDSFEVEVMSWLATYIPRTIRFADIRPPETNRPFVTFK

Query:  ANGNFYFVDKEHCHNKALLARLTPQQRESAFRNL
        ANGNFYFVDKEHCHNKALLARLTPQQRESAFRNL
Subjt:  ANGNFYFVDKEHCHNKALLARLTPQQRESAFRNL

XP_038890893.1 uncharacterized protein LOC120080328 [Benincasa hispida]

1.6e-115

89.41

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Query:  MTRAALFHLLRSQSKHISRRNYYSGYHLQRSTAWINEKFVPTSNFLSQKNAVQKRWASQAPTREDDGKISIGPERG--SEEDEKDVAYIGPISSTIKKVK
        MTRAALFHLLRSQSK++SRRN++SGYHLQRS+AWINEK VPTSNFLS ++AVQKRWASQA TREDD KISIGP RG  +EE+EKDVAY+GPISSTIKKVK
Subjt:  MTRAALFHLLRSQSKHISRRNYYSGYHLQRSTAWINEKFVPTSNFLSQKNAVQKRWASQAPTREDDGKISIGPERG--SEEDEKDVAYIGPISSTIKKVK

Query:  LLSLSTCCLSVSLGPVITFMTSPDMNVILKGVVASSVIFLSATTTGALHWFVSPYVHKIRWKPGSDSFEVEVMSWLATYIPRTIRFADIRPPETNRPFVT
        LLSLSTCCLSVSLGPVITFMTSPDMNVI+KG VASSVIFLSA+TT ALHWFVSPYVHKIRWKPGSDSFEVE+MSWLATYIPRTIRFADIRPPETNRPFVT
Subjt:  LLSLSTCCLSVSLGPVITFMTSPDMNVILKGVVASSVIFLSATTTGALHWFVSPYVHKIRWKPGSDSFEVEVMSWLATYIPRTIRFADIRPPETNRPFVT

Query:  FKANGNFYFVDKEHCHNKALLARLTPQQRESAFRNL
        FKANG+FYFVDKEHCHNKALLARLTPQQ ESAF+NL
Subjt:  FKANGNFYFVDKEHCHNKALLARLTPQQRESAFRNL

TrEMBL top hits

e value

%identity

Alignment

A0A0A0KQP8 Uncharacterized protein

1.7e-123

96.61

Show/hide

Query:  MTRAALFHLLRSQSKHISRRNYYSGYHLQRSTAWINEKFVPTSNFLSQKNAVQKRWASQAPTREDDGKISIGPERG--SEEDEKDVAYIGPISSTIKKVK
        MTRAALFHLLRSQSKHISRRNYYSGYHLQRSTAWINEKFVPTSNFLSQKNAVQKRWASQA TREDDGKISIGP RG  +EEDEKDVAYIGPISSTIKKVK
Subjt:  MTRAALFHLLRSQSKHISRRNYYSGYHLQRSTAWINEKFVPTSNFLSQKNAVQKRWASQAPTREDDGKISIGPERG--SEEDEKDVAYIGPISSTIKKVK

Query:  LLSLSTCCLSVSLGPVITFMTSPDMNVILKGVVASSVIFLSATTTGALHWFVSPYVHKIRWKPGSDSFEVEVMSWLATYIPRTIRFADIRPPETNRPFVT
        LLSLSTCCLSVSLGPVITFMTSPDMNVILKGVVASSVIFLSATTTGALHWFVSPYVHKIRWKPGSDSFEVEVMSWLATYIPRTIRFADIRPPETNRPFVT
Subjt:  LLSLSTCCLSVSLGPVITFMTSPDMNVILKGVVASSVIFLSATTTGALHWFVSPYVHKIRWKPGSDSFEVEVMSWLATYIPRTIRFADIRPPETNRPFVT

Query:  FKANGNFYFVDKEHCHNKALLARLTPQQRESAFRNL
        FKANG+FYFVDKEHC NKALLARLTPQQRESA RNL
Subjt:  FKANGNFYFVDKEHCHNKALLARLTPQQRESAFRNL

A0A1S3CPD9 uncharacterized protein LOC103503301

2.7e-129

100

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Query:  MTRAALFHLLRSQSKHISRRNYYSGYHLQRSTAWINEKFVPTSNFLSQKNAVQKRWASQAPTREDDGKISIGPERGSEEDEKDVAYIGPISSTIKKVKLL
        MTRAALFHLLRSQSKHISRRNYYSGYHLQRSTAWINEKFVPTSNFLSQKNAVQKRWASQAPTREDDGKISIGPERGSEEDEKDVAYIGPISSTIKKVKLL
Subjt:  MTRAALFHLLRSQSKHISRRNYYSGYHLQRSTAWINEKFVPTSNFLSQKNAVQKRWASQAPTREDDGKISIGPERGSEEDEKDVAYIGPISSTIKKVKLL

Query:  SLSTCCLSVSLGPVITFMTSPDMNVILKGVVASSVIFLSATTTGALHWFVSPYVHKIRWKPGSDSFEVEVMSWLATYIPRTIRFADIRPPETNRPFVTFK
        SLSTCCLSVSLGPVITFMTSPDMNVILKGVVASSVIFLSATTTGALHWFVSPYVHKIRWKPGSDSFEVEVMSWLATYIPRTIRFADIRPPETNRPFVTFK
Subjt:  SLSTCCLSVSLGPVITFMTSPDMNVILKGVVASSVIFLSATTTGALHWFVSPYVHKIRWKPGSDSFEVEVMSWLATYIPRTIRFADIRPPETNRPFVTFK

Query:  ANGNFYFVDKEHCHNKALLARLTPQQRESAFRNL
        ANGNFYFVDKEHCHNKALLARLTPQQRESAFRNL
Subjt:  ANGNFYFVDKEHCHNKALLARLTPQQRESAFRNL

A0A5A7TAZ9 Uncharacterized protein

1.6e-116

97.7

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Query:  SRRNYYSGYHLQRSTAWINEKFVPTSNFLSQKNAVQKRWASQAPTREDDGKISIGPERGSEEDEKDVAYIGPISSTIKKVKLLSLSTCCLSVSLGPVITF
        S+ ++ SGYHLQRSTAWINEKFVPTSNFLSQKNAVQKRWASQAPTREDDGKISIGPERGSEEDEKDVAYIGPISSTIKKVKLLSLSTCCLSVSLGPVITF
Subjt:  SRRNYYSGYHLQRSTAWINEKFVPTSNFLSQKNAVQKRWASQAPTREDDGKISIGPERGSEEDEKDVAYIGPISSTIKKVKLLSLSTCCLSVSLGPVITF

Query:  MTSPDMNVILKGVVASSVIFLSATTTGALHWFVSPYVHKIRWKPGSDSFEVEVMSWLATYIPRTIRFADIRPPETNRPFVTFKANGNFYFVDKEHCHNKA
        MTSPDMNVILKGVVASSVIFLSATTTGALHWFVSPYVHKIRWKPGSDSFEVEVMSWLATYIPRTIRFADIRPPETNRPFVTFKANGNFYFVDKEHCHNKA
Subjt:  MTSPDMNVILKGVVASSVIFLSATTTGALHWFVSPYVHKIRWKPGSDSFEVEVMSWLATYIPRTIRFADIRPPETNRPFVTFKANGNFYFVDKEHCHNKA

Query:  LLARLTPQQRESAFRNL
        LLARLTPQQRESAFRNL
Subjt:  LLARLTPQQRESAFRNL

A0A6J1HK45 uncharacterized protein LOC111464841 isoform X1

9.1e-109

85.59

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Query:  MTRAALFHLLRSQSKHISRRNYYSGYHLQRSTAWINEKFVPTSNFLSQKNAVQKRWASQAPTREDDGKISIGPERG--SEEDEKDVAYIGPISSTIKKVK
        MTRAALF LLRSQSKH+S+RN +SGYHLQ S+AWI++    TS+F+S+ +AVQKRWASQA TRED+ KISIGP RG   EEDEKDVAYIGPISSTIKKVK
Subjt:  MTRAALFHLLRSQSKHISRRNYYSGYHLQRSTAWINEKFVPTSNFLSQKNAVQKRWASQAPTREDDGKISIGPERG--SEEDEKDVAYIGPISSTIKKVK

Query:  LLSLSTCCLSVSLGPVITFMTSPDMNVILKGVVASSVIFLSATTTGALHWFVSPYVHKIRWKPGSDSFEVEVMSWLATYIPRTIRFADIRPPETNRPFVT
        LLSLSTCCLSVSLGPVITFMTSPDMNVILKG VASSVIF SATTTG LHWFVSPYVHKIRWKPGSDSFEVE+MSWLATYIPRTIRFADIRPPETNRPFVT
Subjt:  LLSLSTCCLSVSLGPVITFMTSPDMNVILKGVVASSVIFLSATTTGALHWFVSPYVHKIRWKPGSDSFEVEVMSWLATYIPRTIRFADIRPPETNRPFVT

Query:  FKANGNFYFVDKEHCHNKALLARLTPQQRESAFRNL
        FKANG+FYFVD+EHC NKALLARLTPQQ+ESAF+NL
Subjt:  FKANGNFYFVDKEHCHNKALLARLTPQQRESAFRNL

A0A6J1HPF5 uncharacterized protein LOC111464841 isoform X2

9.1e-109

85.59

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Query:  MTRAALFHLLRSQSKHISRRNYYSGYHLQRSTAWINEKFVPTSNFLSQKNAVQKRWASQAPTREDDGKISIGPERG--SEEDEKDVAYIGPISSTIKKVK
        MTRAALF LLRSQSKH+S+RN +SGYHLQ S+AWI++    TS+F+S+ +AVQKRWASQA TRED+ KISIGP RG   EEDEKDVAYIGPISSTIKKVK
Subjt:  MTRAALFHLLRSQSKHISRRNYYSGYHLQRSTAWINEKFVPTSNFLSQKNAVQKRWASQAPTREDDGKISIGPERG--SEEDEKDVAYIGPISSTIKKVK

Query:  LLSLSTCCLSVSLGPVITFMTSPDMNVILKGVVASSVIFLSATTTGALHWFVSPYVHKIRWKPGSDSFEVEVMSWLATYIPRTIRFADIRPPETNRPFVT
        LLSLSTCCLSVSLGPVITFMTSPDMNVILKG VASSVIF SATTTG LHWFVSPYVHKIRWKPGSDSFEVE+MSWLATYIPRTIRFADIRPPETNRPFVT
Subjt:  LLSLSTCCLSVSLGPVITFMTSPDMNVILKGVVASSVIFLSATTTGALHWFVSPYVHKIRWKPGSDSFEVEVMSWLATYIPRTIRFADIRPPETNRPFVT

Query:  FKANGNFYFVDKEHCHNKALLARLTPQQRESAFRNL
        FKANG+FYFVD+EHC NKALLARLTPQQ+ESAF+NL
Subjt:  FKANGNFYFVDKEHCHNKALLARLTPQQRESAFRNL

SwissProt top hits	e value	%identity	Alignment
No hits found

Arabidopsis top hits

e value

%identity

Alignment

AT2G35790.1 unknown protein

1.4e-77

64.02

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Query:  MTRAALFHLLRSQSKHISRRNYYSGYHLQRSTAWINEKFVPTSNFLSQKNAVQKRWAS-QAPTREDDG--KISIGPERGSEEDEKDVAYIGPISSTIKKV
        M R+AL HLLRSQS+ +S   + SGYH  RS A      V         +  Q+ WAS  A TREDD   KISIGP+   EE +  V Y GPISSTIKKV
Subjt:  MTRAALFHLLRSQSKHISRRNYYSGYHLQRSTAWINEKFVPTSNFLSQKNAVQKRWAS-QAPTREDDG--KISIGPERGSEEDEKDVAYIGPISSTIKKV

Query:  KLLSLSTCCLSVSLGPVITFMTSPDMNVILKGVVASSVIFLSATTTGALHWFVSPYVHKIRWKPGSDSFEVEVMSWLATYIPRTIRFADIRPPETNRPFV
        KLLSLSTCCLSVSLGPVITFMTSP +NVI+KG VAS+VIFLSA+TT ALHWFVSPYVHK+RW+PGSD+FEVE+M+WL T+  +T++F+DIR P+T RP+V
Subjt:  KLLSLSTCCLSVSLGPVITFMTSPDMNVILKGVVASSVIFLSATTTGALHWFVSPYVHKIRWKPGSDSFEVEVMSWLATYIPRTIRFADIRPPETNRPFV

Query:  TFKANGNFYFVDKEHCHNKALLARLTPQQ--RESAFRNL
        +FKA+GNFYFVD +HC NKALLARLTP +   +SAF+NL
Subjt:  TFKANGNFYFVDKEHCHNKALLARLTPQQ--RESAFRNL

Sequences

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CDS sequence

Show/hide CDS sequence

ATGACGAGGGCCGCTCTCTTCCATTTGCTACGATCACAATCCAAACATATCTCGCGAAGAAATTACTATTCAGGTTATCATCTCCAACGATCAACAGCATGGATC
AATGAAAAATTTGTACCCACTAGCAACTTTCTTTCGCAGAAAAATGCAGTCCAGAAGAGATGGGCATCTCAAGCTCCAACAAGAGAAGATGATGGCAAGATCAGC
ATTGGACCTGAAAGAGGATCCGAGGAAGATGAAAAAGATGTTGCTTATATTGGGCCAATCTCGTCGACCATCAAGAAAGTCAAGCTTCTATCTTTATCTACATGC
TGCCTCTCTGTATCACTCGGACCAGTCATAACCTTCATGACGTCCCCTGACATGAATGTGATTCTGAAAGGTGTTGTTGCATCATCTGTGATATTCCTCAGTGCT
ACTACTACTGGAGCACTTCACTGGTTCGTGAGCCCTTATGTTCATAAAATTAGATGGAAACCAGGTTCAGACAGTTTTGAGGTTGAGGTTATGTCGTGGCTGGCA
ACTTACATTCCACGAACCATTCGATTTGCTGATATTCGACCACCCGAAACAAACCGTCCCTTTGTGACCTTCAAGGCTAATGGGAACTTCTACTTTGTAGACAAA
GAGCACTGTCATAATAAGGCACTCTTAGCCAGACTGACTCCTCAGCAACGTGAATCGGCTTTTAGAAACTTATGA

mRNA sequence

Show/hide mRNA sequence

CCATTTTGCAGTTTGGAAGTAGAGCAAGGGAAGAGTTTTTGCTTCTGGAGAATGACGAGGGCCGCTCTCTTCCATTTGCTACGATCACAATCCAAACATATCTCG
CGAAGAAATTACTATTCAGGTTATCATCTCCAACGATCAACAGCATGGATCAATGAAAAATTTGTACCCACTAGCAACTTTCTTTCGCAGAAAAATGCAGTCCAG
AAGAGATGGGCATCTCAAGCTCCAACAAGAGAAGATGATGGCAAGATCAGCATTGGACCTGAAAGAGGATCCGAGGAAGATGAAAAAGATGTTGCTTATATTGGG
CCAATCTCGTCGACCATCAAGAAAGTCAAGCTTCTATCTTTATCTACATGCTGCCTCTCTGTATCACTCGGACCAGTCATAACCTTCATGACGTCCCCTGACATG
AATGTGATTCTGAAAGGTGTTGTTGCATCATCTGTGATATTCCTCAGTGCTACTACTACTGGAGCACTTCACTGGTTCGTGAGCCCTTATGTTCATAAAATTAGA
TGGAAACCAGGTTCAGACAGTTTTGAGGTTGAGGTTATGTCGTGGCTGGCAACTTACATTCCACGAACCATTCGATTTGCTGATATTCGACCACCCGAAACAAAC
CGTCCCTTTGTGACCTTCAAGGCTAATGGGAACTTCTACTTTGTAGACAAAGAGCACTGTCATAATAAGGCACTCTTAGCCAGACTGACTCCTCAGCAACGTGAA
TCGGCTTTTAGAAACTTATGATTGTCTTGGAGATTTTTCCTTTTCTTCATTGAGTTGAAGGCCAATGAGATGGCTGAACTGTTGTCATAAATCATGTATACTTTC
ACCATAGACAAATTGCTGCTCATTGTACCGTTTAGATCAATTTTGGCAGAATATGGTCTTTTTTAAACACAATTCATGTGTACAACCTTTGATAACTGATAGATG
ATAGAACCATATATTACGTGGTTTGGAATTTTAAAAATAGTTTCTATTAACATTTTCCTTATGTATTTTGAAAAGATACTCATATAGTATAACCTTTCATAAATT
TTTTTACTACGTAATCCATTTTGATCCAAATTACTTTTTGGACTGAATTTAAGATTTGTTTAAAGTTTAGCGATAATGCAATCTTTAATTCTTAACCTAAAAGTT
CAAACTTTTTGTTGATAGGAAGATTTATACCTAAGAAACTAACCCCTTATATGAAATTTAAATCATCCAAAGAGCAAAGAAAAATAAAATATTC

Protein sequence

Show/hide protein sequence

MTRAALFHLLRSQSKHISRRNYYSGYHLQRSTAWINEKFVPTSNFLSQKNAVQKRWASQAPTREDDGKISIGPERGSEEDEKDVAYIGPISSTIKKVKLLSLSTC
CLSVSLGPVITFMTSPDMNVILKGVVASSVIFLSATTTGALHWFVSPYVHKIRWKPGSDSFEVEVMSWLATYIPRTIRFADIRPPETNRPFVTFKANGNFYFVDK
EHCHNKALLARLTPQQRESAFRNL

Cmc09g0244201 (gene) of Melon (Charmono) v1.1 genome