; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; CuGenDBv2

CmoCh01G006940 (gene) of Cucurbita moschata (Rifu) v1 genome

Gene IDCmoCh01G006940
OrganismCucurbita moschata Rifu (Cucurbita moschata (Rifu) v1)
DescriptionnudC domain-containing protein 2-like
Genome locationCmo_Chr01:3541674..3543604
RNA-Seq ExpressionCmoCh01G006940
SyntenyCmoCh01G006940
Gene Ontology termsGO:0006457 - protein folding (biological process)
GO:0005737 - cytoplasm (cellular component)
GO:0051082 - unfolded protein binding (molecular function)
InterPro domainsIPR007052 - CS domain
IPR008978 - HSP20-like chaperone
IPR037898 - NudC family


Homology Show/hide homology
GenBank top hitse value%identityAlignment
KAG6607306.1 NudC domain-containing protein 2, partial [Cucurbita argyrosperma subsp. sororia]3.5e-9099.37Show/hide
Query:  MAEKLAPEKRHSFLHNGQEVFEWDQTLEEVNMYINLPPNVHSKQFYCKIQSRHVELGIKGNPPYLNHELTCPVKTDSSFWTLEDGIMHITLQKRDKGQTW
        MAEKLAPEKRHSFLHNGQEVFEWDQTLEEVNMYINLPPNVHSKQFYCKIQSRHVELGIKGNPPYLNHELTCPVKTDSSFWTLEDGIMHITLQKRDKGQTW
Subjt:  MAEKLAPEKRHSFLHNGQEVFEWDQTLEEVNMYINLPPNVHSKQFYCKIQSRHVELGIKGNPPYLNHELTCPVKTDSSFWTLEDGIMHITLQKRDKGQTW

Query:  ASPIQGQGRLDPYSTDLEQKRLMLQRFQEENPGFDFSQAQFSGNCPDPRTFMGGIHSD
        ASPIQGQG+LDPYSTDLEQKRLMLQRFQEENPGFDFSQAQFSGNCPDPRTFMGGIHSD
Subjt:  ASPIQGQGRLDPYSTDLEQKRLMLQRFQEENPGFDFSQAQFSGNCPDPRTFMGGIHSD

KAG7036985.1 NudC domain-containing protein 2 [Cucurbita argyrosperma subsp. argyrosperma]1.7e-8998.73Show/hide
Query:  MAEKLAPEKRHSFLHNGQEVFEWDQTLEEVNMYINLPPNVHSKQFYCKIQSRHVELGIKGNPPYLNHELTCPVKTDSSFWTLEDGIMHITLQKRDKGQTW
        MAEKLAPEKRHSFLHNGQEVFEWDQTLEEVNMYINLPPNVHSKQFYCKIQSRHVELGIKGNPPYLNHELTCPVKTDSSFWTLEDGIMHITLQKRDKGQTW
Subjt:  MAEKLAPEKRHSFLHNGQEVFEWDQTLEEVNMYINLPPNVHSKQFYCKIQSRHVELGIKGNPPYLNHELTCPVKTDSSFWTLEDGIMHITLQKRDKGQTW

Query:  ASPIQGQGRLDPYSTDLEQKRLMLQRFQEENPGFDFSQAQFSGNCPDPRTFMGGIHSD
        ASPIQG G+LDPYSTDLEQKRLMLQRFQEENPGFDFSQAQFSGNCPDPRTFMGGIHSD
Subjt:  ASPIQGQGRLDPYSTDLEQKRLMLQRFQEENPGFDFSQAQFSGNCPDPRTFMGGIHSD

XP_022948776.1 nudC domain-containing protein 2-like [Cucurbita moschata]1.2e-90100Show/hide
Query:  MAEKLAPEKRHSFLHNGQEVFEWDQTLEEVNMYINLPPNVHSKQFYCKIQSRHVELGIKGNPPYLNHELTCPVKTDSSFWTLEDGIMHITLQKRDKGQTW
        MAEKLAPEKRHSFLHNGQEVFEWDQTLEEVNMYINLPPNVHSKQFYCKIQSRHVELGIKGNPPYLNHELTCPVKTDSSFWTLEDGIMHITLQKRDKGQTW
Subjt:  MAEKLAPEKRHSFLHNGQEVFEWDQTLEEVNMYINLPPNVHSKQFYCKIQSRHVELGIKGNPPYLNHELTCPVKTDSSFWTLEDGIMHITLQKRDKGQTW

Query:  ASPIQGQGRLDPYSTDLEQKRLMLQRFQEENPGFDFSQAQFSGNCPDPRTFMGGIHSD
        ASPIQGQGRLDPYSTDLEQKRLMLQRFQEENPGFDFSQAQFSGNCPDPRTFMGGIHSD
Subjt:  ASPIQGQGRLDPYSTDLEQKRLMLQRFQEENPGFDFSQAQFSGNCPDPRTFMGGIHSD

XP_022998001.1 nudC domain-containing protein 2-like [Cucurbita maxima]1.2e-8796.2Show/hide
Query:  MAEKLAPEKRHSFLHNGQEVFEWDQTLEEVNMYINLPPNVHSKQFYCKIQSRHVELGIKGNPPYLNHELTCPVKTDSSFWTLEDGIMHITLQKRDKGQTW
        MAEKLAPEKRHSF+HNGQ+VFEWDQTLEEVN+YINLPPNVHSKQFYCKIQSRHVELGIK NPPYLNHELTCPVKTDSSFWTLEDGIMHITLQKRDKGQTW
Subjt:  MAEKLAPEKRHSFLHNGQEVFEWDQTLEEVNMYINLPPNVHSKQFYCKIQSRHVELGIKGNPPYLNHELTCPVKTDSSFWTLEDGIMHITLQKRDKGQTW

Query:  ASPIQGQGRLDPYSTDLEQKRLMLQRFQEENPGFDFSQAQFSGNCPDPRTFMGGIHSD
        ASPIQGQG+LDPYSTDLEQKRLMLQRFQEENPGFDFS+AQFSGNCPDPRTFMGGIHSD
Subjt:  ASPIQGQGRLDPYSTDLEQKRLMLQRFQEENPGFDFSQAQFSGNCPDPRTFMGGIHSD

XP_023523271.1 nudC domain-containing protein 2-like isoform X2 [Cucurbita pepo subsp. pepo]3.8e-8998.1Show/hide
Query:  MAEKLAPEKRHSFLHNGQEVFEWDQTLEEVNMYINLPPNVHSKQFYCKIQSRHVELGIKGNPPYLNHELTCPVKTDSSFWTLEDGIMHITLQKRDKGQTW
        MAEKLAPEKRHSFLHNGQEVFEWDQTLEEVN+YINLPPNVHSKQFYCKIQSRHVELGIKGNPPYL+HELTCPVKTDSSFWTLEDGIMHITLQKRDKGQTW
Subjt:  MAEKLAPEKRHSFLHNGQEVFEWDQTLEEVNMYINLPPNVHSKQFYCKIQSRHVELGIKGNPPYLNHELTCPVKTDSSFWTLEDGIMHITLQKRDKGQTW

Query:  ASPIQGQGRLDPYSTDLEQKRLMLQRFQEENPGFDFSQAQFSGNCPDPRTFMGGIHSD
        ASPIQGQG+LDPYSTDLEQKRLMLQRFQEENPGFDFSQAQFSGNCPDPRTFMGGIHSD
Subjt:  ASPIQGQGRLDPYSTDLEQKRLMLQRFQEENPGFDFSQAQFSGNCPDPRTFMGGIHSD

TrEMBL top hitse value%identityAlignment
A0A0A0LV57 CS domain-containing protein7.3e-8696.77Show/hide
Query:  MAEKLAPEKRHSFLHNGQEVFEWDQTLEEVNMYINLPPNVHSKQFYCKIQSRHVELGIKGNPPYLNHELTCPVKTDSSFWTLEDGIMHITLQKRDKGQTW
        MAEKLAPEKRHSFLHNGQEVFEWDQTLEEVN+YINLPPNV+SKQFYCKIQSRHVELGIKGNPPYLNHELTCPVKTDSSFWTLED IMHITLQKRDKGQTW
Subjt:  MAEKLAPEKRHSFLHNGQEVFEWDQTLEEVNMYINLPPNVHSKQFYCKIQSRHVELGIKGNPPYLNHELTCPVKTDSSFWTLEDGIMHITLQKRDKGQTW

Query:  ASPIQGQGRLDPYSTDLEQKRLMLQRFQEENPGFDFSQAQFSGNCPDPRTFMGGI
        ASPIQGQG+LDPYS+DLEQKRLMLQRFQEENPGFDFSQAQFSGNCPDPRTFMGGI
Subjt:  ASPIQGQGRLDPYSTDLEQKRLMLQRFQEENPGFDFSQAQFSGNCPDPRTFMGGI

A0A445AMU9 CS domain-containing protein3.6e-8592.41Show/hide
Query:  MAEKLAPEKRHSFLHNGQEVFEWDQTLEEVNMYINLPPNVHSKQFYCKIQSRHVELGIKGNPPYLNHELTCPVKTDSSFWTLEDGIMHITLQKRDKGQTW
        MAEKLAPEKRH+F+H+GQ+VFEWDQTLEEVN+YINLPPNVHSKQFYCKIQS+HVE+GIKGNPPYLNH+LTCPVKTDSSFWTLEDGIMHITLQKRDKGQTW
Subjt:  MAEKLAPEKRHSFLHNGQEVFEWDQTLEEVNMYINLPPNVHSKQFYCKIQSRHVELGIKGNPPYLNHELTCPVKTDSSFWTLEDGIMHITLQKRDKGQTW

Query:  ASPIQGQGRLDPYSTDLEQKRLMLQRFQEENPGFDFSQAQFSGNCPDPRTFMGGIHSD
        ASPI GQG+LDPY+TDLEQKRLMLQRFQEENPGFDFSQAQFSGNCPDPRTFMGGI SD
Subjt:  ASPIQGQGRLDPYSTDLEQKRLMLQRFQEENPGFDFSQAQFSGNCPDPRTFMGGIHSD

A0A6J1DD50 nudC domain-containing protein 21.9e-8694.94Show/hide
Query:  MAEKLAPEKRHSFLHNGQEVFEWDQTLEEVNMYINLPPNVHSKQFYCKIQSRHVELGIKGNPPYLNHELTCPVKTDSSFWTLEDGIMHITLQKRDKGQTW
        M EKLAPEKRHSFLHNGQEVFEWDQTLEEVNMYINLPPNVHSKQFYCK+QSRHVE+GIKGNPPYLNH+LT PVKTDSSFWTLEDGIMHITLQKRDKGQTW
Subjt:  MAEKLAPEKRHSFLHNGQEVFEWDQTLEEVNMYINLPPNVHSKQFYCKIQSRHVELGIKGNPPYLNHELTCPVKTDSSFWTLEDGIMHITLQKRDKGQTW

Query:  ASPIQGQGRLDPYSTDLEQKRLMLQRFQEENPGFDFSQAQFSGNCPDPRTFMGGIHSD
        ASPIQGQG+LDPYSTDLEQKRLMLQRFQEENPGFDFSQAQF+GNCPDPRTFMGGI SD
Subjt:  ASPIQGQGRLDPYSTDLEQKRLMLQRFQEENPGFDFSQAQFSGNCPDPRTFMGGIHSD

A0A6J1GA51 nudC domain-containing protein 2-like5.8e-91100Show/hide
Query:  MAEKLAPEKRHSFLHNGQEVFEWDQTLEEVNMYINLPPNVHSKQFYCKIQSRHVELGIKGNPPYLNHELTCPVKTDSSFWTLEDGIMHITLQKRDKGQTW
        MAEKLAPEKRHSFLHNGQEVFEWDQTLEEVNMYINLPPNVHSKQFYCKIQSRHVELGIKGNPPYLNHELTCPVKTDSSFWTLEDGIMHITLQKRDKGQTW
Subjt:  MAEKLAPEKRHSFLHNGQEVFEWDQTLEEVNMYINLPPNVHSKQFYCKIQSRHVELGIKGNPPYLNHELTCPVKTDSSFWTLEDGIMHITLQKRDKGQTW

Query:  ASPIQGQGRLDPYSTDLEQKRLMLQRFQEENPGFDFSQAQFSGNCPDPRTFMGGIHSD
        ASPIQGQGRLDPYSTDLEQKRLMLQRFQEENPGFDFSQAQFSGNCPDPRTFMGGIHSD
Subjt:  ASPIQGQGRLDPYSTDLEQKRLMLQRFQEENPGFDFSQAQFSGNCPDPRTFMGGIHSD

A0A6J1K923 nudC domain-containing protein 2-like6.0e-8896.2Show/hide
Query:  MAEKLAPEKRHSFLHNGQEVFEWDQTLEEVNMYINLPPNVHSKQFYCKIQSRHVELGIKGNPPYLNHELTCPVKTDSSFWTLEDGIMHITLQKRDKGQTW
        MAEKLAPEKRHSF+HNGQ+VFEWDQTLEEVN+YINLPPNVHSKQFYCKIQSRHVELGIK NPPYLNHELTCPVKTDSSFWTLEDGIMHITLQKRDKGQTW
Subjt:  MAEKLAPEKRHSFLHNGQEVFEWDQTLEEVNMYINLPPNVHSKQFYCKIQSRHVELGIKGNPPYLNHELTCPVKTDSSFWTLEDGIMHITLQKRDKGQTW

Query:  ASPIQGQGRLDPYSTDLEQKRLMLQRFQEENPGFDFSQAQFSGNCPDPRTFMGGIHSD
        ASPIQGQG+LDPYSTDLEQKRLMLQRFQEENPGFDFS+AQFSGNCPDPRTFMGGIHSD
Subjt:  ASPIQGQGRLDPYSTDLEQKRLMLQRFQEENPGFDFSQAQFSGNCPDPRTFMGGIHSD

SwissProt top hitse value%identityAlignment
Q5M823 NudC domain-containing protein 24.7e-2142.06Show/hide
Query:  EWDQTLEEVNMYINLPPNVHSKQFYCKIQSRHVELGIKGNPPYLNHELTCPVKTDSSFWTLEDGIM---HITLQKRDKGQTWASPIQGQGRLDPYSTDLE
        +W QTLEEV + + +PP   ++   C +QSRHV L + G    L  +L      D   WTLED  M    +T  KRD    W S ++ +   DP+  D  
Subjt:  EWDQTLEEVNMYINLPPNVHSKQFYCKIQSRHVELGIKGNPPYLNHELTCPVKTDSSFWTLEDGIM---HITLQKRDKGQTWASPIQGQGRLDPYSTDLE

Query:  QKRLMLQRFQEENPGFDFSQAQFSGN
        Q++L L+RFQ+ENPGFDFS A+ SGN
Subjt:  QKRLMLQRFQEENPGFDFSQAQFSGN

Q8WVJ2 NudC domain-containing protein 22.7e-2140Show/hide
Query:  EKRHSFLHNGQEVFEWDQTLEEVNMYINLPPNVHSKQFYCKIQSRHVELGIKGNPPYLNHELTCPVKTDSSFWTLEDGIM---HITLQKRDKGQTWASPI
        E+R   +  G    +W QTLEEV + + +PP   ++   C +QSRHV L + G    L  +L      D   WTLED  M    +T  KRD    W S +
Subjt:  EKRHSFLHNGQEVFEWDQTLEEVNMYINLPPNVHSKQFYCKIQSRHVELGIKGNPPYLNHELTCPVKTDSSFWTLEDGIM---HITLQKRDKGQTWASPI

Query:  QGQGRLDPYSTDLEQKRLMLQRFQEENPGFDFSQAQFSGN
        + +   DP+  D  Q++L L+RFQ+ENPGFDFS A+ SGN
Subjt:  QGQGRLDPYSTDLEQKRLMLQRFQEENPGFDFSQAQFSGN

Q9CQ48 NudC domain-containing protein 22.7e-2140Show/hide
Query:  EKRHSFLHNGQEVFEWDQTLEEVNMYINLPPNVHSKQFYCKIQSRHVELGIKGNPPYLNHELTCPVKTDSSFWTLEDGIM---HITLQKRDKGQTWASPI
        E+R   +  G    +W QTLEEV + + +PP   ++   C +QSRHV L + G    L  +L      D   WTLED  M    +T  KRD    W S +
Subjt:  EKRHSFLHNGQEVFEWDQTLEEVNMYINLPPNVHSKQFYCKIQSRHVELGIKGNPPYLNHELTCPVKTDSSFWTLEDGIM---HITLQKRDKGQTWASPI

Query:  QGQGRLDPYSTDLEQKRLMLQRFQEENPGFDFSQAQFSGN
        + +   DP+  D  Q++L L+RFQ+ENPGFDFS A+ SGN
Subjt:  QGQGRLDPYSTDLEQKRLMLQRFQEENPGFDFSQAQFSGN

Q9LV09 Protein BOBBER 13.9e-1225.62Show/hide
Query:  EVFEWDQTLEEVNMYINLPPNVHSKQFYCKIQSRHVELGIKGNPPYLNHELTCPVKTDSSFWTLED-GIMHITLQKRDKGQTWASPIQGQGRLDPYSTDL
        E + W Q L+EV + I +P    ++   C+I+   +++G+KG  P ++ EL   VK D  +W +ED  ++ I L K D+ + W   ++G+  +D    + 
Subjt:  EVFEWDQTLEEVNMYINLPPNVHSKQFYCKIQSRHVELGIKGNPPYLNHELTCPVKTDSSFWTLED-GIMHITLQKRDKGQTWASPIQGQGRLDPYSTDL

Query:  E-----------------------------------QKRLMLQRFQEENPGFDFSQAQFS
        E                                   QK+ +L++F  E+P  DFS A+F+
Subjt:  E-----------------------------------QKRLMLQRFQEENPGFDFSQAQFS

Q9STN7 Protein BOBBER 28.0e-1327.5Show/hide
Query:  EVFEWDQTLEEVNMYINLPPNVHSKQFYCKIQSRHVELGIKGNPPYLNHELTCPVKTDSSFWTLED-GIMHITLQKRDKGQTWASPIQGQ----------
        E + W Q L+EV + I +P    S+   C+I+   +++G+KG    ++ E    VK D  FW +ED  ++ + L K+D+ + W   ++G+          
Subjt:  EVFEWDQTLEEVNMYINLPPNVHSKQFYCKIQSRHVELGIKGNPPYLNHELTCPVKTDSSFWTLED-GIMHITLQKRDKGQTWASPIQGQ----------

Query:  -----GRLDPYS--------------------TDLEQKRLMLQRFQEENPGFDFSQAQFS
             G LDP +                    +D  +K+ ML++F  +NPG DFS A+F+
Subjt:  -----GRLDPYS--------------------TDLEQKRLMLQRFQEENPGFDFSQAQFS

Arabidopsis top hitse value%identityAlignment
AT4G27890.1 HSP20-like chaperones superfamily protein5.7e-1427.5Show/hide
Query:  EVFEWDQTLEEVNMYINLPPNVHSKQFYCKIQSRHVELGIKGNPPYLNHELTCPVKTDSSFWTLED-GIMHITLQKRDKGQTWASPIQGQ----------
        E + W Q L+EV + I +P    S+   C+I+   +++G+KG    ++ E    VK D  FW +ED  ++ + L K+D+ + W   ++G+          
Subjt:  EVFEWDQTLEEVNMYINLPPNVHSKQFYCKIQSRHVELGIKGNPPYLNHELTCPVKTDSSFWTLED-GIMHITLQKRDKGQTWASPIQGQ----------

Query:  -----GRLDPYS--------------------TDLEQKRLMLQRFQEENPGFDFSQAQFS
             G LDP +                    +D  +K+ ML++F  +NPG DFS A+F+
Subjt:  -----GRLDPYS--------------------TDLEQKRLMLQRFQEENPGFDFSQAQFS

AT5G53400.1 HSP20-like chaperones superfamily protein2.8e-1325.62Show/hide
Query:  EVFEWDQTLEEVNMYINLPPNVHSKQFYCKIQSRHVELGIKGNPPYLNHELTCPVKTDSSFWTLED-GIMHITLQKRDKGQTWASPIQGQGRLDPYSTDL
        E + W Q L+EV + I +P    ++   C+I+   +++G+KG  P ++ EL   VK D  +W +ED  ++ I L K D+ + W   ++G+  +D    + 
Subjt:  EVFEWDQTLEEVNMYINLPPNVHSKQFYCKIQSRHVELGIKGNPPYLNHELTCPVKTDSSFWTLED-GIMHITLQKRDKGQTWASPIQGQGRLDPYSTDL

Query:  E-----------------------------------QKRLMLQRFQEENPGFDFSQAQFS
        E                                   QK+ +L++F  E+P  DFS A+F+
Subjt:  E-----------------------------------QKRLMLQRFQEENPGFDFSQAQFS

AT5G58740.1 HSP20-like chaperones superfamily protein1.5e-8386.71Show/hide
Query:  MAEKLAPEKRHSFLHNGQEVFEWDQTLEEVNMYINLPPNVHSKQFYCKIQSRHVELGIKGNPPYLNHELTCPVKTDSSFWTLEDGIMHITLQKRDKGQTW
        MAEKLAPEKRH F+HNGQ+VFEWDQTLEEVNMYI LPPNVH K F+CKIQS+H+E+GIKGNPPYLNH+L+ PVKTD SFWTLED IMHITLQKR+KGQTW
Subjt:  MAEKLAPEKRHSFLHNGQEVFEWDQTLEEVNMYINLPPNVHSKQFYCKIQSRHVELGIKGNPPYLNHELTCPVKTDSSFWTLEDGIMHITLQKRDKGQTW

Query:  ASPIQGQGRLDPYSTDLEQKRLMLQRFQEENPGFDFSQAQFSGNCPDPRTFMGGIHSD
        ASPI GQG+LDPY+TDLEQKRLMLQRFQEENPGFDFSQAQFSGNCPDPR+FMGGI SD
Subjt:  ASPIQGQGRLDPYSTDLEQKRLMLQRFQEENPGFDFSQAQFSGNCPDPRTFMGGIHSD


Sequences Show/hide sequences
CDS sequenceShow/hide CDS sequence
ATGGCAGAGAAATTGGCTCCAGAAAAGCGCCATAGCTTTCTCCACAACGGTCAGGAAGTGTTTGAATGGGATCAGACTCTGGAGGAGGTTAATATGTATATTAATTTGCC
TCCAAATGTTCATTCAAAGCAATTCTACTGCAAGATTCAGTCTAGACATGTCGAGCTTGGGATTAAGGGGAATCCTCCTTATCTCAATCACGAACTTACTTGCCCTGTGA
AGACGGATTCGTCTTTCTGGACGCTAGAGGATGGCATAATGCACATTACACTGCAGAAGAGGGACAAGGGTCAGACATGGGCTTCTCCCATACAGGGTCAGGGTCGTCTT
GATCCTTACTCCACTGATCTTGAGCAGAAGCGTCTTATGCTCCAAAGGTTTCAGGAGGAGAACCCTGGATTTGACTTCTCACAAGCTCAGTTTTCGGGCAACTGTCCCGA
TCCAAGGACCTTCATGGGTGGAATTCACTCAGATTGA
mRNA sequenceShow/hide mRNA sequence
AACCAAGGGAAAAGCTTCTGTGTGAAACTCGCGGGAAAGGGGAAGAAGGAAGAAGCGAACCCTAAGAAATGGCAGAGAAATTGGCTCCAGAAAAGCGCCATAGCTTTCTC
CACAACGGTCAGGAAGTGTTTGAATGGGATCAGACTCTGGAGGAGGTTAATATGTATATTAATTTGCCTCCAAATGTTCATTCAAAGCAATTCTACTGCAAGATTCAGTC
TAGACATGTCGAGCTTGGGATTAAGGGGAATCCTCCTTATCTCAATCACGAACTTACTTGCCCTGTGAAGACGGATTCGTCTTTCTGGACGCTAGAGGATGGCATAATGC
ACATTACACTGCAGAAGAGGGACAAGGGTCAGACATGGGCTTCTCCCATACAGGGTCAGGGTCGTCTTGATCCTTACTCCACTGATCTTGAGCAGAAGCGTCTTATGCTC
CAAAGGTTTCAGGAGGAGAACCCTGGATTTGACTTCTCACAAGCTCAGTTTTCGGGCAACTGTCCCGATCCAAGGACCTTCATGGGTGGAATTCACTCAGATTGA
Protein sequenceShow/hide protein sequence
MAEKLAPEKRHSFLHNGQEVFEWDQTLEEVNMYINLPPNVHSKQFYCKIQSRHVELGIKGNPPYLNHELTCPVKTDSSFWTLEDGIMHITLQKRDKGQTWASPIQGQGRL
DPYSTDLEQKRLMLQRFQEENPGFDFSQAQFSGNCPDPRTFMGGIHSD