CuGenDBv2

Gene ID	CmoCh06G014320
Organism	Cucurbita moschata Rifu (Cucurbita moschata (Rifu) v1)
Description	NEDD8-activating enzyme E1 catalytic subunit
Genome location	Cmo_Chr06:10386789..10387136
RNA-Seq Expression	CmoCh06G014320
Synteny	CmoCh06G014320
Gene Ontology terms	GO:0016567 - protein ubiquitination (biological process) GO:0045116 - protein neddylation (biological process) GO:0005634 - nucleus (cellular component) GO:0005737 - cytoplasm (cellular component) GO:0005524 - ATP binding (molecular function) GO:0019781 - NEDD8 activating enzyme activity (molecular function)
InterPro domains	IPR000594 - THIF-type NAD/FAD binding fold IPR030468 - NEDD8-activating enzyme E1 catalytic subunit IPR035985 - Ubiquitin-activating enzyme

Homology

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GenBank top hits

e value

%identity

Alignment

XP_004134149.1 NEDD8-activating enzyme E1 catalytic subunit [Cucumis sativus]

3.5e-25

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Query:  RDLDKLLHRPGNLIGANFEPGSRLRDDLQQYVQVLVIGDGA-----SEDLAVSGFRNLEVIDMDRIEVTNLNPQFLFRFQ
        RDLDKLL RPGNLIGANFEPGS+LRDDLQQYV+VLVIG G       +DLA+SGFRNLEVIDMDRIEVTNLN QFLFR +
Subjt:  RDLDKLLHRPGNLIGANFEPGSRLRDDLQQYVQVLVIGDGA-----SEDLAVSGFRNLEVIDMDRIEVTNLNPQFLFRFQ

XP_022138079.1 NEDD8-activating enzyme E1 catalytic subunit isoform X1 [Momordica charantia]

2.1e-25

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Query:  RDLDKLLHRPGNLIGANFEPGSRLRDDLQQYVQVLVIGDGA-----SEDLAVSGFRNLEVIDMDRIEVTNLNPQFLFRFQ
        RDLDKLL RPGNLIGANFEPGS+LRDDLQQYV+VLV+G G       +DLA+SGFRNLEVIDMDRIEVTNLN QFLFR Q
Subjt:  RDLDKLLHRPGNLIGANFEPGSRLRDDLQQYVQVLVIGDGA-----SEDLAVSGFRNLEVIDMDRIEVTNLNPQFLFRFQ

XP_022138080.1 NEDD8-activating enzyme E1 catalytic subunit isoform X2 [Momordica charantia]

2.1e-25

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Query:  RDLDKLLHRPGNLIGANFEPGSRLRDDLQQYVQVLVIGDGA-----SEDLAVSGFRNLEVIDMDRIEVTNLNPQFLFRFQ
        RDLDKLL RPGNLIGANFEPGS+LRDDLQQYV+VLV+G G       +DLA+SGFRNLEVIDMDRIEVTNLN QFLFR Q
Subjt:  RDLDKLLHRPGNLIGANFEPGSRLRDDLQQYVQVLVIGDGA-----SEDLAVSGFRNLEVIDMDRIEVTNLNPQFLFRFQ

XP_022138081.1 NEDD8-activating enzyme E1 catalytic subunit isoform X3 [Momordica charantia]

2.1e-25

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Query:  RDLDKLLHRPGNLIGANFEPGSRLRDDLQQYVQVLVIGDGA-----SEDLAVSGFRNLEVIDMDRIEVTNLNPQFLFRFQ
        RDLDKLL RPGNLIGANFEPGS+LRDDLQQYV+VLV+G G       +DLA+SGFRNLEVIDMDRIEVTNLN QFLFR Q
Subjt:  RDLDKLLHRPGNLIGANFEPGSRLRDDLQQYVQVLVIGDGA-----SEDLAVSGFRNLEVIDMDRIEVTNLNPQFLFRFQ

XP_022138082.1 NEDD8-activating enzyme E1 catalytic subunit isoform X4 [Momordica charantia]

2.1e-25

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Query:  RDLDKLLHRPGNLIGANFEPGSRLRDDLQQYVQVLVIGDGA-----SEDLAVSGFRNLEVIDMDRIEVTNLNPQFLFRFQ
        RDLDKLL RPGNLIGANFEPGS+LRDDLQQYV+VLV+G G       +DLA+SGFRNLEVIDMDRIEVTNLN QFLFR Q
Subjt:  RDLDKLLHRPGNLIGANFEPGSRLRDDLQQYVQVLVIGDGA-----SEDLAVSGFRNLEVIDMDRIEVTNLNPQFLFRFQ

TrEMBL top hits

e value

%identity

Alignment

A0A5D3D1R8 NEDD8-activating enzyme E1 catalytic subunit

1.7e-25

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Query:  RDLDKLLHRPGNLIGANFEPGSRLRDDLQQYVQVLVIGDGA-----SEDLAVSGFRNLEVIDMDRIEVTNLNPQFLFRFQ
        RDLDKLL RPGNLIGANFEPGS+LRDDLQQYV+VLVIG G       +DLA+SGFRNLEVIDMDRIEVTNLN QFLFR +
Subjt:  RDLDKLLHRPGNLIGANFEPGSRLRDDLQQYVQVLVIGDGA-----SEDLAVSGFRNLEVIDMDRIEVTNLNPQFLFRFQ

A0A6J1C8F5 NEDD8-activating enzyme E1 catalytic subunit

1.0e-25

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Query:  RDLDKLLHRPGNLIGANFEPGSRLRDDLQQYVQVLVIGDGA-----SEDLAVSGFRNLEVIDMDRIEVTNLNPQFLFRFQ
        RDLDKLL RPGNLIGANFEPGS+LRDDLQQYV+VLV+G G       +DLA+SGFRNLEVIDMDRIEVTNLN QFLFR Q
Subjt:  RDLDKLLHRPGNLIGANFEPGSRLRDDLQQYVQVLVIGDGA-----SEDLAVSGFRNLEVIDMDRIEVTNLNPQFLFRFQ

A0A6J1C8P8 NEDD8-activating enzyme E1 catalytic subunit

1.0e-25

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Query:  RDLDKLLHRPGNLIGANFEPGSRLRDDLQQYVQVLVIGDGA-----SEDLAVSGFRNLEVIDMDRIEVTNLNPQFLFRFQ
        RDLDKLL RPGNLIGANFEPGS+LRDDLQQYV+VLV+G G       +DLA+SGFRNLEVIDMDRIEVTNLN QFLFR Q
Subjt:  RDLDKLLHRPGNLIGANFEPGSRLRDDLQQYVQVLVIGDGA-----SEDLAVSGFRNLEVIDMDRIEVTNLNPQFLFRFQ

A0A6J1C926 NEDD8-activating enzyme E1 catalytic subunit

1.0e-25

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Query:  RDLDKLLHRPGNLIGANFEPGSRLRDDLQQYVQVLVIGDGA-----SEDLAVSGFRNLEVIDMDRIEVTNLNPQFLFRFQ
        RDLDKLL RPGNLIGANFEPGS+LRDDLQQYV+VLV+G G       +DLA+SGFRNLEVIDMDRIEVTNLN QFLFR Q
Subjt:  RDLDKLLHRPGNLIGANFEPGSRLRDDLQQYVQVLVIGDGA-----SEDLAVSGFRNLEVIDMDRIEVTNLNPQFLFRFQ

A0A6J1CA17 NEDD8-activating enzyme E1 catalytic subunit

1.0e-25

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Query:  RDLDKLLHRPGNLIGANFEPGSRLRDDLQQYVQVLVIGDGA-----SEDLAVSGFRNLEVIDMDRIEVTNLNPQFLFRFQ
        RDLDKLL RPGNLIGANFEPGS+LRDDLQQYV+VLV+G G       +DLA+SGFRNLEVIDMDRIEVTNLN QFLFR Q
Subjt:  RDLDKLLHRPGNLIGANFEPGSRLRDDLQQYVQVLVIGDGA-----SEDLAVSGFRNLEVIDMDRIEVTNLNPQFLFRFQ

SwissProt top hits

e value

%identity

Alignment

O65041 NEDD8-activating enzyme E1 catalytic subunit

1.1e-21

66.25

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Query:  RDLDKLLHRPGNLIGANFEPGSRLRDDLQQYVQVLVIGDGA-----SEDLAVSGFRNLEVIDMDRIEVTNLNPQFLFRFQ
        RDLDKLL R GNL+   F PG  LRDD++ YV++LVIG G       +DLA+SGFRNLEVIDMDRIEVTNLN QFLFR +
Subjt:  RDLDKLLHRPGNLIGANFEPGSRLRDDLQQYVQVLVIGDGA-----SEDLAVSGFRNLEVIDMDRIEVTNLNPQFLFRFQ

Q54QG9 NEDD8-activating enzyme E1 catalytic subunit

1.8e-11

44.44

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Query:  DLDKLLHRPGNLIGANFEPGSR----LRDDLQQYVQVLVIGDGA-----SEDLAVSGFRNLEVIDMDRIEVTNLNPQFLFR
        D++K++ R G     +FEP ++    + + LQ   +VLVIG G       ++LA+SGFRN++VIDMD I+++NLN QFLFR
Subjt:  DLDKLLHRPGNLIGANFEPGSR----LRDDLQQYVQVLVIGDGA-----SEDLAVSGFRNLEVIDMDRIEVTNLNPQFLFR

Q5R4A0 NEDD8-activating enzyme E1 catalytic subunit

2.8e-09

47.3

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Query:  KLLHRPGNLIGANFEPGSRLRDDLQQYVQVLVIGDGA-----SEDLAVSGFRNLEVIDMDRIEVTNLNPQFLFR
        K L R G     +FEP +     L    +VLVIG G       ++LA+SGFR + VIDMD I+V+NLN QFLFR
Subjt:  KLLHRPGNLIGANFEPGSRLRDDLQQYVQVLVIGDGA-----SEDLAVSGFRNLEVIDMDRIEVTNLNPQFLFR

Q8C878 NEDD8-activating enzyme E1 catalytic subunit

2.8e-09

47.3

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Query:  KLLHRPGNLIGANFEPGSRLRDDLQQYVQVLVIGDGA-----SEDLAVSGFRNLEVIDMDRIEVTNLNPQFLFR
        K L R G     +FEP +     L    +VLVIG G       ++LA+SGFR + VIDMD I+V+NLN QFLFR
Subjt:  KLLHRPGNLIGANFEPGSRLRDDLQQYVQVLVIGDGA-----SEDLAVSGFRNLEVIDMDRIEVTNLNPQFLFR

Q8TBC4 NEDD8-activating enzyme E1 catalytic subunit

2.8e-09

47.3

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Query:  KLLHRPGNLIGANFEPGSRLRDDLQQYVQVLVIGDGA-----SEDLAVSGFRNLEVIDMDRIEVTNLNPQFLFR
        K L R G     +FEP +     L    +VLVIG G       ++LA+SGFR + VIDMD I+V+NLN QFLFR
Subjt:  KLLHRPGNLIGANFEPGSRLRDDLQQYVQVLVIGDGA-----SEDLAVSGFRNLEVIDMDRIEVTNLNPQFLFR

Arabidopsis top hits

e value

%identity

Alignment

AT2G21470.1 SUMO-activating enzyme 2

6.6e-06

52.17

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Query:  QVLVIGDGA-----SEDLAVSGFRNLEVIDMDRIEVTNLNPQFLFR
        +VL++G G       + LA+SGF ++ +IDMD IEV+NLN QFLFR
Subjt:  QVLVIGDGA-----SEDLAVSGFRNLEVIDMDRIEVTNLNPQFLFR

AT2G21470.2 SUMO-activating enzyme 2

6.6e-06

52.17

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Query:  QVLVIGDGA-----SEDLAVSGFRNLEVIDMDRIEVTNLNPQFLFR
        +VL++G G       + LA+SGF ++ +IDMD IEV+NLN QFLFR
Subjt:  QVLVIGDGA-----SEDLAVSGFRNLEVIDMDRIEVTNLNPQFLFR

AT2G21470.3 SUMO-activating enzyme 2

6.6e-06

52.17

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Query:  QVLVIGDGA-----SEDLAVSGFRNLEVIDMDRIEVTNLNPQFLFR
        +VL++G G       + LA+SGF ++ +IDMD IEV+NLN QFLFR
Subjt:  QVLVIGDGA-----SEDLAVSGFRNLEVIDMDRIEVTNLNPQFLFR

AT5G19180.1 E1 C-terminal related 1

7.8e-23

66.25

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Query:  RDLDKLLHRPGNLIGANFEPGSRLRDDLQQYVQVLVIGDGA-----SEDLAVSGFRNLEVIDMDRIEVTNLNPQFLFRFQ
        RDLDKLL R GNL+   F PG  LRDD++ YV++LVIG G       +DLA+SGFRNLEVIDMDRIEVTNLN QFLFR +
Subjt:  RDLDKLLHRPGNLIGANFEPGSRLRDDLQQYVQVLVIGDGA-----SEDLAVSGFRNLEVIDMDRIEVTNLNPQFLFRFQ

Sequences

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CDS sequence

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GAAAGGGACCTCGACAAGCTCCTCCATAGGCCCGGTAACCTCATTGGCGCCAATTTTGAGCCCGGTTCTCGATTGAGGGATGATCTTCAACAGTACGTTCAAGTG
TTGGTCATTGGAGATGGAGCGTCGGAAGATTTGGCTGTGTCGGGTTTTCGGAATCTGGAAGTCATTGACATGGATCGCATCGAAGTTACAAATCTCAATCCTCAG
TTTCTCTTCAGGTTCCAACGATTTTCACGGTTCTATGCGTAG

mRNA sequence

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Protein sequence

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ERDLDKLLHRPGNLIGANFEPGSRLRDDLQQYVQVLVIGDGASEDLAVSGFRNLEVIDMDRIEVTNLNPQFLFRFQRFSRFYA

CmoCh06G014320 (gene) of Cucurbita moschata (Rifu) v1 genome