CuGenDBv2

Gene ID	CmoCh09G010170
Organism	Cucurbita moschata Rifu (Cucurbita moschata (Rifu) v1)
Description	NAD-dependent protein deacetylase SRT1
Genome location	Cmo_Chr09:5411127..5413585
RNA-Seq Expression	CmoCh09G010170
Synteny	CmoCh09G010170
Gene Ontology terms	GO:0000122 - negative regulation of transcription by RNA polymerase II (biological process) GO:0070932 - histone H3 deacetylation (biological process) GO:0005634 - nucleus (cellular component) GO:0005739 - mitochondrion (cellular component) GO:0003714 - transcription corepressor activity (molecular function) GO:0004407 - histone deacetylase activity (molecular function) GO:0016740 - transferase activity (molecular function) GO:0046872 - metal ion binding (molecular function) GO:0070403 - NAD+ binding (molecular function)
InterPro domains	IPR003000 - Sirtuin family IPR026590 - Sirtuin family, catalytic core domain IPR029035 - DHS-like NAD/FAD-binding domain superfamily

Homology

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GenBank top hits

e value

%identity

Alignment

KAG6592099.1 NAD-dependent protein deacetylase SRT1, partial [Cucurbita argyrosperma subsp. sororia]

7.6e-35

100

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Query:  MSLGYAEKLSFIEDVGKVGMTEHFDPPHVLEEKIERLTMMIQKSKHLVVFTGAGISTSCGIPDFRGPKGIWTLQ
        MSLGYAEKLSFIEDVGKVGMTEHFDPPHVLEEKIERLTMMIQKSKHLVVFTGAGISTSCGIPDFRGPKGIWTLQ
Subjt:  MSLGYAEKLSFIEDVGKVGMTEHFDPPHVLEEKIERLTMMIQKSKHLVVFTGAGISTSCGIPDFRGPKGIWTLQ

KAG7030271.1 NAD-dependent protein deacetylase SRT1 [Cucurbita argyrosperma subsp. argyrosperma]

7.6e-35

100

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Query:  MSLGYAEKLSFIEDVGKVGMTEHFDPPHVLEEKIERLTMMIQKSKHLVVFTGAGISTSCGIPDFRGPKGIWTLQ
        MSLGYAEKLSFIEDVGKVGMTEHFDPPHVLEEKIERLTMMIQKSKHLVVFTGAGISTSCGIPDFRGPKGIWTLQ
Subjt:  MSLGYAEKLSFIEDVGKVGMTEHFDPPHVLEEKIERLTMMIQKSKHLVVFTGAGISTSCGIPDFRGPKGIWTLQ

XP_022936498.1 NAD-dependent protein deacetylase SRT1 isoform X1 [Cucurbita moschata]

7.6e-35

100

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Query:  MSLGYAEKLSFIEDVGKVGMTEHFDPPHVLEEKIERLTMMIQKSKHLVVFTGAGISTSCGIPDFRGPKGIWTLQ
        MSLGYAEKLSFIEDVGKVGMTEHFDPPHVLEEKIERLTMMIQKSKHLVVFTGAGISTSCGIPDFRGPKGIWTLQ
Subjt:  MSLGYAEKLSFIEDVGKVGMTEHFDPPHVLEEKIERLTMMIQKSKHLVVFTGAGISTSCGIPDFRGPKGIWTLQ

XP_022975852.1 NAD-dependent protein deacetylase SRT1 isoform X1 [Cucurbita maxima]

7.6e-35

100

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Query:  MSLGYAEKLSFIEDVGKVGMTEHFDPPHVLEEKIERLTMMIQKSKHLVVFTGAGISTSCGIPDFRGPKGIWTLQ
        MSLGYAEKLSFIEDVGKVGMTEHFDPPHVLEEKIERLTMMIQKSKHLVVFTGAGISTSCGIPDFRGPKGIWTLQ
Subjt:  MSLGYAEKLSFIEDVGKVGMTEHFDPPHVLEEKIERLTMMIQKSKHLVVFTGAGISTSCGIPDFRGPKGIWTLQ

XP_023536490.1 NAD-dependent protein deacetylase SRT1 isoform X1 [Cucurbita pepo subsp. pepo]

7.6e-35

100

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Query:  MSLGYAEKLSFIEDVGKVGMTEHFDPPHVLEEKIERLTMMIQKSKHLVVFTGAGISTSCGIPDFRGPKGIWTLQ
        MSLGYAEKLSFIEDVGKVGMTEHFDPPHVLEEKIERLTMMIQKSKHLVVFTGAGISTSCGIPDFRGPKGIWTLQ
Subjt:  MSLGYAEKLSFIEDVGKVGMTEHFDPPHVLEEKIERLTMMIQKSKHLVVFTGAGISTSCGIPDFRGPKGIWTLQ

TrEMBL top hits

e value

%identity

Alignment

A0A1S3CI81 NAD-dependent protein deacetylase SRT1 isoform X1

1.2e-33

95.95

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Query:  MSLGYAEKLSFIEDVGKVGMTEHFDPPHVLEEKIERLTMMIQKSKHLVVFTGAGISTSCGIPDFRGPKGIWTLQ
        MSLGYAEKLS+IEDVG+VGMTEHFDPPHVLEEKIERLT MIQKSKHLVVFTGAGISTSCGIPDFRGPKGIWTLQ
Subjt:  MSLGYAEKLSFIEDVGKVGMTEHFDPPHVLEEKIERLTMMIQKSKHLVVFTGAGISTSCGIPDFRGPKGIWTLQ

A0A6J1CGI6 NAD-dependent protein deacetylase SRT1

8.2e-35

98.65

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Query:  MSLGYAEKLSFIEDVGKVGMTEHFDPPHVLEEKIERLTMMIQKSKHLVVFTGAGISTSCGIPDFRGPKGIWTLQ
        MSLGYAEKLS+IEDVGKVGMTEHFDPPHVLEEKIERLTMMIQKSKHLVVFTGAGISTSCGIPDFRGPKGIWTLQ
Subjt:  MSLGYAEKLSFIEDVGKVGMTEHFDPPHVLEEKIERLTMMIQKSKHLVVFTGAGISTSCGIPDFRGPKGIWTLQ

A0A6J1FDE4 NAD-dependent protein deacetylase SRT1 isoform X1

3.7e-35

100

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Query:  MSLGYAEKLSFIEDVGKVGMTEHFDPPHVLEEKIERLTMMIQKSKHLVVFTGAGISTSCGIPDFRGPKGIWTLQ
        MSLGYAEKLSFIEDVGKVGMTEHFDPPHVLEEKIERLTMMIQKSKHLVVFTGAGISTSCGIPDFRGPKGIWTLQ
Subjt:  MSLGYAEKLSFIEDVGKVGMTEHFDPPHVLEEKIERLTMMIQKSKHLVVFTGAGISTSCGIPDFRGPKGIWTLQ

A0A6J1IE68 NAD-dependent protein deacetylase SRT1 isoform X1

3.7e-35

100

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Query:  MSLGYAEKLSFIEDVGKVGMTEHFDPPHVLEEKIERLTMMIQKSKHLVVFTGAGISTSCGIPDFRGPKGIWTLQ
        MSLGYAEKLSFIEDVGKVGMTEHFDPPHVLEEKIERLTMMIQKSKHLVVFTGAGISTSCGIPDFRGPKGIWTLQ
Subjt:  MSLGYAEKLSFIEDVGKVGMTEHFDPPHVLEEKIERLTMMIQKSKHLVVFTGAGISTSCGIPDFRGPKGIWTLQ

A0A6P5SWY7 NAD-dependent protein deacetylase SRT1 isoform X1

1.5e-33

93.24

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Query:  MSLGYAEKLSFIEDVGKVGMTEHFDPPHVLEEKIERLTMMIQKSKHLVVFTGAGISTSCGIPDFRGPKGIWTLQ
        MSLGYAEKLS+IEDVG+VGMTEHFDPPHVL+EKIERLTM++QKSKHLVVFTGAGISTSCGIPDFRGPKGIWTLQ
Subjt:  MSLGYAEKLSFIEDVGKVGMTEHFDPPHVLEEKIERLTMMIQKSKHLVVFTGAGISTSCGIPDFRGPKGIWTLQ

SwissProt top hits

e value

%identity

Alignment

B8ARK7 NAD-dependent protein deacetylase SRT1

7.9e-27

75.68

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Query:  MSLGYAEKLSFIEDVGKVGMTEHFDPPHVLEEKIERLTMMIQKSKHLVVFTGAGISTSCGIPDFRGPKGIWTLQ
        MSLGYAEKLS+ EDVG VGM E FD P +L +KIE L +M+++SKHLVVFTGAGISTS GIPDFRGPKG+WTLQ
Subjt:  MSLGYAEKLSFIEDVGKVGMTEHFDPPHVLEEKIERLTMMIQKSKHLVVFTGAGISTSCGIPDFRGPKGIWTLQ

P59941 NAD-dependent protein deacetylase sirtuin-6

8.2e-16

52.7

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Query:  MSLGYAEKLSFIEDVGKVGMTEHFDPPHVLEEKIERLTMMIQKSKHLVVFTGAGISTSCGIPDFRGPKGIWTLQ
        MS+ YA  LS   D GK G+ E FDPP  LE K+  L  ++ +S  +V  TGAGIST+ GIPDFRGP G+WT++
Subjt:  MSLGYAEKLSFIEDVGKVGMTEHFDPPHVLEEKIERLTMMIQKSKHLVVFTGAGISTSCGIPDFRGPKGIWTLQ

Q8N6T7 NAD-dependent protein deacetylase sirtuin-6

4.8e-16

52.7

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Query:  MSLGYAEKLSFIEDVGKVGMTEHFDPPHVLEEKIERLTMMIQKSKHLVVFTGAGISTSCGIPDFRGPKGIWTLQ
        MS+ YA  LS   D GK G+ E FDPP  LE K+  L  ++ +S  +V  TGAGIST+ GIPDFRGP G+WT++
Subjt:  MSLGYAEKLSFIEDVGKVGMTEHFDPPHVLEEKIERLTMMIQKSKHLVVFTGAGISTSCGIPDFRGPKGIWTLQ

Q9FE17 NAD-dependent protein deacetylase SRT1

9.0e-31

85.14

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Query:  MSLGYAEKLSFIEDVGKVGMTEHFDPPHVLEEKIERLTMMIQKSKHLVVFTGAGISTSCGIPDFRGPKGIWTLQ
        MSLGYAEKLSFIEDVG+VGM E FDP H+L+ KIE L  +IQKSKHLVVFTGAGISTSCGIPDFRGPKGIWTLQ
Subjt:  MSLGYAEKLSFIEDVGKVGMTEHFDPPHVLEEKIERLTMMIQKSKHLVVFTGAGISTSCGIPDFRGPKGIWTLQ

Q9VH08 NAD-dependent protein deacetylase Sirt6

4.4e-17

55.41

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Query:  MSLGYAEKLSFIEDVGKVGMTEHFDPPHVLEEKIERLTMMIQKSKHLVVFTGAGISTSCGIPDFRGPKGIWTLQ
        MS  YA+ LS  ++ G +G  E FD   V+ EK + L  +I+KS H+V+ TGAGISTS GIPDFRGPKG+WTL+
Subjt:  MSLGYAEKLSFIEDVGKVGMTEHFDPPHVLEEKIERLTMMIQKSKHLVVFTGAGISTSCGIPDFRGPKGIWTLQ

Arabidopsis top hits

e value

%identity

Alignment

AT5G09230.1 sirtuin 2

1.1e-07

45.83

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Query:  DPPHVLEEKIERLTMMIQKSKHLVVFTGAGISTSCGIPDFRGPKGIWT
        DPP++  E I +L  + ++S  L + TGAG+ST CGIPD+R P G ++
Subjt:  DPPHVLEEKIERLTMMIQKSKHLVVFTGAGISTSCGIPDFRGPKGIWT

AT5G09230.2 sirtuin 2

1.1e-07

45.83

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Query:  DPPHVLEEKIERLTMMIQKSKHLVVFTGAGISTSCGIPDFRGPKGIWT
        DPP++  E I +L  + ++S  L + TGAG+ST CGIPD+R P G ++
Subjt:  DPPHVLEEKIERLTMMIQKSKHLVVFTGAGISTSCGIPDFRGPKGIWT

AT5G09230.3 sirtuin 2

1.1e-07

45.83

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Query:  DPPHVLEEKIERLTMMIQKSKHLVVFTGAGISTSCGIPDFRGPKGIWT
        DPP++  E I +L  + ++S  L + TGAG+ST CGIPD+R P G ++
Subjt:  DPPHVLEEKIERLTMMIQKSKHLVVFTGAGISTSCGIPDFRGPKGIWT

AT5G09230.5 sirtuin 2

1.1e-07

45.83

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Query:  DPPHVLEEKIERLTMMIQKSKHLVVFTGAGISTSCGIPDFRGPKGIWT
        DPP++  E I +L  + ++S  L + TGAG+ST CGIPD+R P G ++
Subjt:  DPPHVLEEKIERLTMMIQKSKHLVVFTGAGISTSCGIPDFRGPKGIWT

AT5G55760.1 sirtuin 1

6.4e-32

85.14

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Query:  MSLGYAEKLSFIEDVGKVGMTEHFDPPHVLEEKIERLTMMIQKSKHLVVFTGAGISTSCGIPDFRGPKGIWTLQ
        MSLGYAEKLSFIEDVG+VGM E FDP H+L+ KIE L  +IQKSKHLVVFTGAGISTSCGIPDFRGPKGIWTLQ
Subjt:  MSLGYAEKLSFIEDVGKVGMTEHFDPPHVLEEKIERLTMMIQKSKHLVVFTGAGISTSCGIPDFRGPKGIWTLQ

Sequences

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CDS sequence

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ATGTCTCTGGGTTACGCAGAGAAGCTTTCGTTCATAGAAGACGTTGGAAAAGTGGGAATGACAGAACATTTTGACCCACCTCACGTTTTAGAAGAAAAGATTGAGCGACT
AACTATGATGATACAAAAGAGCAAGCATCTAGTGGTGTTTACAGGTGCAGGAATATCGACCTCTTGTGGCATACCTGATTTTCGAGGTCCTAAAGGAATATGGACTCTTC
AGGCGAGTTATATCTCCTACGCTATGTCTAATAAGATACGTTTGAGGCTCGAGCAACCTTTTTTTATCTGGATTTATTAA

mRNA sequence

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CTTATGCTTGAAGTACTTGGGAGCATATCGAGGGGCGGAGCGAGAGGGGTCCTGACTTTCGTGTCTGGAGCTTCTCTTTGATCATCTTAGCTTCAGCTTCTGGGGGCGAA
ACTAAGAGAAAGTGGGTCAGCACCGGCAGCACAGACAGCACAGACAGCGCAGACACCATGTCTCTGGGTTACGCAGAGAAGCTTTCGTTCATAGAAGACGTTGGAAAAGT
GGGAATGACAGAACATTTTGACCCACCTCACGTTTTAGAAGAAAAGATTGAGCGACTAACTATGATGATACAAAAGAGCAAGCATCTAGTGGTGTTTACAGGTGCAGGAA
TATCGACCTCTTGTGGCATACCTGATTTTCGAGGTCCTAAAGGAATATGGACTCTTCAGGCGAGTTATATCTCCTACGCTATGTCTAATAAGATACGTTTGAGGCTCGAG
CAACCTTTTTTTATCTGGATTTATTAA

Protein sequence

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MSLGYAEKLSFIEDVGKVGMTEHFDPPHVLEEKIERLTMMIQKSKHLVVFTGAGISTSCGIPDFRGPKGIWTLQASYISYAMSNKIRLRLEQPFFIWIY

CmoCh09G010170 (gene) of Cucurbita moschata (Rifu) v1 genome