CuGenDBv2

Gene ID	Cucsat.G603
Organism	Cucumis sativus L. var. sativus cv. B10 (Cucumber (B10) v3)
Description	DNA topoisomerase
Genome location	ctg1:11691315..11706796
RNA-Seq Expression	Cucsat.G603
Synteny	Cucsat.G603
Gene Ontology terms	GO:0006265 - DNA topological change (biological process) GO:0055085 - transmembrane transport (biological process) GO:0005634 - nucleus (cellular component) GO:0016021 - integral component of membrane (cellular component) GO:0003677 - DNA binding (molecular function) GO:0022857 - transmembrane transporter activity (molecular function) GO:0003917 - DNA topoisomerase type I activity (molecular function)
InterPro domains	IPR003602 - DNA topoisomerase, type IA, DNA-binding domain IPR034144 - DNA topoisomerase 3-like, TOPRIM domain IPR023406 - DNA topoisomerase, type IA, active site IPR023405 - DNA topoisomerase, type IA, core domain IPR013826 - DNA topoisomerase, type IA, central region, subdomain 3 IPR013825 - DNA topoisomerase, type IA, central region, subdomain 2 IPR013824 - DNA topoisomerase, type IA, central region, subdomain 1 IPR013497 - DNA topoisomerase, type IA, central IPR006171 - TOPRIM domain IPR003601 - DNA topoisomerase, type IA, domain 2 IPR000380 - DNA topoisomerase, type IA

Homology

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GenBank top hits

e value

%identity

Alignment

KAA0067650.1 DNA topoisomerase 3-beta [Cucumis melo var. makuwa]

0.0

97.13

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Query:  MVAPTVLMVAEKPSIALSIASALSHGQMSTRKGSTEVHEFDGRFLGHHAYYKVTSVIGHVFSIDFQAGFQDWKSTDPLDLFQASVIKTESNPKAHICQHL
        MVA TVLMVAEKPSIALSIASALSHGQMSTRKGSTEVHEFDGRFLGHHAYYKVTSVIGH+FSIDFQAGFQDWK+T+PLDLFQASVIKTESNPKAHI QHL
Subjt:  MVAPTVLMVAEKPSIALSIASALSHGQMSTRKGSTEVHEFDGRFLGHHAYYKVTSVIGHVFSIDFQAGFQDWKSTDPLDLFQASVIKTESNPKAHICQHL

Query:  SREARGCDCLVLWLDCDREGENICFEVIECSGFGGNGTRKKVYRARFSSVTEKDILKALDNLVEPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYG
        SREARGCDCLVLWLDCDREGENICFEVIEC+GFGGNGTRKKVYRARFSSVTEKDILKALDNLVEPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYG
Subjt:  SREARGCDCLVLWLDCDREGENICFEVIECSGFGGNGTRKKVYRARFSSVTEKDILKALDNLVEPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYG

Query:  NLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYILQTGYELNLDWERGKLFDCDVTAMFQKRVIEDGIAEVTEISEKQENKVRPSGLNTVNL
        NLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYI+Q GYELNLDWERGKLFDCDVTAMFQKRVIEDGIAEVTEISEKQENKVRPSGLNTVNL
Subjt:  NLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYILQTGYELNLDWERGKLFDCDVTAMFQKRVIEDGIAEVTEISEKQENKVRPSGLNTVNL

Query:  LKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAW
        LKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMC ATEDMLGRDAW
Subjt:  LKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAW

Query:  RLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAVNEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELISLMEKHG
        RLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAVNEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELISLMEKHG
Subjt:  RLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAVNEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELISLMEKHG

Query:  IGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVVQSVLQQFRQKYSYFVKKIDHMDALF
        IGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVV+SVLQQF+QKYSYFVKKID MDALF
Subjt:  IGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVVQSVLQQFRQKYSYFVKKIDHMDALF

Query:  EAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKGTIKLYKELTCPLDNFELLIYSLPGPEGKSFPLCPYCYNSPPFEGINTLYGA
        EAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKGTIKLYKELTCPLDNFELLI SLPGPEGKSFPLCPYCYNSPPFEGI+TLYGA
Subjt:  EAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKGTIKLYKELTCPLDNFELLIYSLPGPEGKSFPLCPYCYNSPPFEGINTLYGA

Query:  SKANPSSGTSSKGMGMPCFMCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPKGAHRISTTRDKCADCDSTIIEVDFNKKTTP
        SK NPSSGTSSKGMGMPCF+CPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLP+GAHRISTT DKCADCDSTIIEVDFNKKTTP
Subjt:  SKANPSSGTSSKGMGMPCFMCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPKGAHRISTTRDKCADCDSTIIEVDFNKKTTP

Query:  LEDGATLFVGCILCDEFLHSLLEMKHGKSFIRNRGSRGRGRGRGRGRG----GRGRGSGKPMDPKMSFRDF
        LEDGATLFVGCILCDEFLHSLLEMKHG SFIRNR SRGRGRGRGRGRG    GRGR SGKPMDPKMSFRDF
Subjt:  LEDGATLFVGCILCDEFLHSLLEMKHGKSFIRNRGSRGRGRGRGRGRG----GRGRGSGKPMDPKMSFRDF

XP_004147675.1 DNA topoisomerase 3-beta isoform X1 [Cucumis sativus]

0.0

99.77

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Query:  MVAPTVLMVAEKPSIALSIASALSHGQMSTRKGSTEVHEFDGRFLGHHAYYKVTSVIGHVFSIDFQAGFQDWKSTDPLDLFQASVIKTESNPKAHICQHL
        MVAPTVLMVAEKPSIALSIASALSHGQMSTRKGSTEVHEFDGRFLGHHAYYKVTSVIGHVFSIDFQAGFQDWKSTDPLDLFQASVIKTESNPKAHICQHL
Subjt:  MVAPTVLMVAEKPSIALSIASALSHGQMSTRKGSTEVHEFDGRFLGHHAYYKVTSVIGHVFSIDFQAGFQDWKSTDPLDLFQASVIKTESNPKAHICQHL

Query:  SREARGCDCLVLWLDCDREGENICFEVIECSGFGGNGTRKKVYRARFSSVTEKDILKALDNLVEPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYG
        SREARGCDCLVLWLDCDREGENICFEVIEC+GFGGNGTRKKVYRARFSSVTEKDILKALDNLVEPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYG
Subjt:  SREARGCDCLVLWLDCDREGENICFEVIECSGFGGNGTRKKVYRARFSSVTEKDILKALDNLVEPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYG

Query:  NLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYILQTGYELNLDWERGKLFDCDVTAMFQKRVIEDGIAEVTEISEKQENKVRPSGLNTVNL
        NLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYILQTGYELNLDWERGKLFDCDVTAMFQKRVIEDGIAEVTEISEKQENKVRPSGLNTVNL
Subjt:  NLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYILQTGYELNLDWERGKLFDCDVTAMFQKRVIEDGIAEVTEISEKQENKVRPSGLNTVNL

Query:  LKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAW
        LKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAW
Subjt:  LKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAW

Query:  RLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAVNEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELISLMEKHG
        RLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAVNEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELISLMEKHG
Subjt:  RLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAVNEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELISLMEKHG

Query:  IGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVVQSVLQQFRQKYSYFVKKIDHMDALF
        IGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVVQSVLQQFRQKYSYFVKKIDHMDALF
Subjt:  IGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVVQSVLQQFRQKYSYFVKKIDHMDALF

Query:  EAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKGTIKLYKELTCPLDNFELLIYSLPGPEGKSFPLCPYCYNSPPFEGINTLYGA
        EAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKGTIKLYKELTCPLDNFELLIYSLPGPEGKSFPLCPYCYNSPPFEGINTLYGA
Subjt:  EAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKGTIKLYKELTCPLDNFELLIYSLPGPEGKSFPLCPYCYNSPPFEGINTLYGA

Query:  SKANPSSGTSSKGMGMPCFMCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPKGAHRISTTRDKCADCDSTIIEVDFNKKTTP
        SKANPSSGTSSKGMGMPCFMCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPKGAHRISTTRDKCADCDSTIIEVDFNKKTTP
Subjt:  SKANPSSGTSSKGMGMPCFMCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPKGAHRISTTRDKCADCDSTIIEVDFNKKTTP

Query:  LEDGATLFVGCILCDEFLHSLLEMKHGKSFIRNRGSRGRGRGRGRGRGGRGRGSGKPMDPKMSFRDF
        LEDGATLFVGCILCDEFLHSLLEMKHGKSFIRNRGSRGRGRGRGRGRGGRGR SGKPMDPKMSFRDF
Subjt:  LEDGATLFVGCILCDEFLHSLLEMKHGKSFIRNRGSRGRGRGRGRGRGGRGRGSGKPMDPKMSFRDF

XP_008439059.1 PREDICTED: DNA topoisomerase 3-beta [Cucumis melo]

0.0

97.35

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Query:  MVAPTVLMVAEKPSIALSIASALSHGQMSTRKGSTEVHEFDGRFLGHHAYYKVTSVIGHVFSIDFQAGFQDWKSTDPLDLFQASVIKTESNPKAHICQHL
        MVA TVLMVAEKPSIALSIASALSHGQMSTRKGSTEVHEFDGRFLGHHAYYKVTSVIGH+FSIDFQAGFQDWK+T+PLDLFQASVIKTESNPKAHI QHL
Subjt:  MVAPTVLMVAEKPSIALSIASALSHGQMSTRKGSTEVHEFDGRFLGHHAYYKVTSVIGHVFSIDFQAGFQDWKSTDPLDLFQASVIKTESNPKAHICQHL

Query:  SREARGCDCLVLWLDCDREGENICFEVIECSGFGGNGTRKKVYRARFSSVTEKDILKALDNLVEPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYG
        SREARGCDCLVLWLDCDREGENICFEVIEC+GFGGNGTRKKVYRARFSSVTEKDILKALDNLVEPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYG
Subjt:  SREARGCDCLVLWLDCDREGENICFEVIECSGFGGNGTRKKVYRARFSSVTEKDILKALDNLVEPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYG

Query:  NLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYILQTGYELNLDWERGKLFDCDVTAMFQKRVIEDGIAEVTEISEKQENKVRPSGLNTVNL
        NLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYI+Q GYELNLDWERGKLFDCDVTAMFQKRVIEDGIAEVTEISEKQENKVRPSGLNTVNL
Subjt:  NLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYILQTGYELNLDWERGKLFDCDVTAMFQKRVIEDGIAEVTEISEKQENKVRPSGLNTVNL

Query:  LKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAW
        LKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMC ATEDMLGRDAW
Subjt:  LKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAW

Query:  RLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAVNEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELISLMEKHG
        RLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAVNEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELISLMEKHG
Subjt:  RLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAVNEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELISLMEKHG

Query:  IGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVVQSVLQQFRQKYSYFVKKIDHMDALF
        IGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVV+SVLQQF+QKYSYFVKKID MDALF
Subjt:  IGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVVQSVLQQFRQKYSYFVKKIDHMDALF

Query:  EAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKGTIKLYKELTCPLDNFELLIYSLPGPEGKSFPLCPYCYNSPPFEGINTLYGA
        EAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKGTIKLYKELTCPLDNFELLI SLPGPEGKSFPLCPYCYNSPPFEGI+TLYGA
Subjt:  EAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKGTIKLYKELTCPLDNFELLIYSLPGPEGKSFPLCPYCYNSPPFEGINTLYGA

Query:  SKANPSSGTSSKGMGMPCFMCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPKGAHRISTTRDKCADCDSTIIEVDFNKKTTP
        SK NPSSGTSSKGMGMPCF+CPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLP+GAHRISTT DKCADCDSTIIEVDFNKKTTP
Subjt:  SKANPSSGTSSKGMGMPCFMCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPKGAHRISTTRDKCADCDSTIIEVDFNKKTTP

Query:  LEDGATLFVGCILCDEFLHSLLEMKHGKSFIRNRGSRGRGRGRGRGRG--GRGRGSGKPMDPKMSFRDF
        LEDGATLFVGCILCDEFLHSLLEMKHG SFIRNR SRGRGRGRGRGRG  GRGR SGKPMDPKMSFRDF
Subjt:  LEDGATLFVGCILCDEFLHSLLEMKHGKSFIRNRGSRGRGRGRGRGRG--GRGRGSGKPMDPKMSFRDF

XP_023528530.1 DNA topoisomerase 3-beta isoform X1 [Cucurbita pepo subsp. pepo]

0.0

93.55

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Query:  MVAPTVLMVAEKPSIALSIASALSHGQMSTRKGSTEVHEFDGRFLGHHAYYKVTSVIGHVFSIDFQAGFQDWKSTDPLDLFQASVIKTESNPKAHICQHL
        MVA +VLMVAEKPSIALSIASALSHGQMSTRKGSTEVHEFDGRFLGHHA+YKVTSVIGHVFSIDF A FQDWK+TDPLDLFQASVIK ESNPKAHI QHL
Subjt:  MVAPTVLMVAEKPSIALSIASALSHGQMSTRKGSTEVHEFDGRFLGHHAYYKVTSVIGHVFSIDFQAGFQDWKSTDPLDLFQASVIKTESNPKAHICQHL

Query:  SREARGCDCLVLWLDCDREGENICFEVIECSGFGGNGTRKKVYRARFSSVTEKDILKALDNLVEPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYG
        SREARGCDCLVLWLDCDREGENICFEVIEC+GFGGN  RKKVYRARFSSVTEKDILKALDNLVEPNRNEALAVDARQEIDLKVGV+FTRFQTTFFQGKYG
Subjt:  SREARGCDCLVLWLDCDREGENICFEVIECSGFGGNGTRKKVYRARFSSVTEKDILKALDNLVEPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYG

Query:  NLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYILQTGYELNLDWERGKLFDCDVTAMFQKRVIEDGIAEVTEISEKQENKVRPSGLNTVNL
        NLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYI+Q GYELNLDWERG+LFDCDV  MFQKRV+EDGIAEVT+ISEKQE+KVRPSGLNTVNL
Subjt:  NLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYILQTGYELNLDWERGKLFDCDVTAMFQKRVIEDGIAEVTEISEKQENKVRPSGLNTVNL

Query:  LKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAW
        LKVASSALG+GPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLH+LVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPM LATEDM+GRDAW
Subjt:  LKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAW

Query:  RLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAVNEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELISLMEKHG
        RLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGS V VKGFTSIMPWLAVNEKKLPQFLKG+KIEVA+VDLYQGNT+PPDYLSESELISLMEKHG
Subjt:  RLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAVNEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELISLMEKHG

Query:  IGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVVQSVLQQFRQKYSYFVKKIDHMDALF
        IGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIE QIT VAKGQADH SVVQ+VLQQF+QKYSYFVKKIDHMDALF
Subjt:  IGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVVQSVLQQFRQKYSYFVKKIDHMDALF

Query:  EAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKGTIKLYKELTCPLDNFELLIYSLPGPEGKSFPLCPYCYNSPPFEGINTLYGA
        EAQFSPLA+SGRALSKCGKCLRYMKFISSQPQRLYCG CEEVYYLPQ+G IKLYKELTCPLDNFELLI+SLPGPEGKSFPLCPYCYNSPPFEGI+TLYGA
Subjt:  EAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKGTIKLYKELTCPLDNFELLIYSLPGPEGKSFPLCPYCYNSPPFEGINTLYGA

Query:  SKANPSSGTSSKGMGMPCFMCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPKGAHRISTTRDKCADCDSTIIEVDFNKKTTP
        +K NPSSG SSKGMGMPCF+CPHPTCRHSLITQGVCACPECSGTLVLDPV APNWKLNCNKCNCLVFLP+GAHRI+TT +KCA+CDSTIIEVDFNKKTTP
Subjt:  SKANPSSGTSSKGMGMPCFMCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPKGAHRISTTRDKCADCDSTIIEVDFNKKTTP

Query:  LEDGATLFVGCILCDEFLHSLLEMKHGKSFIRNRGSRGRGRGRGRGRG-GRGRGSGKPMDPKMSFRDF
        LE GATLFVGCILCDEFLHSLLEMKHGKSF R RGSRGRGRGRGRGRG GRGR SGK MDPKMSFRDF
Subjt:  LEDGATLFVGCILCDEFLHSLLEMKHGKSFIRNRGSRGRGRGRGRGRG-GRGRGSGKPMDPKMSFRDF

XP_038891105.1 DNA topoisomerase 3-beta isoform X1 [Benincasa hispida]

0.0

94.93

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Query:  MVAPTVLMVAEKPSIALSIASALSHGQMSTRKGSTEVHEFDGRFLGHHAYYKVTSVIGHVFSIDFQAGFQDWKSTDPLDLFQASVIKTESNPKAHICQHL
        MVA TVLMVAEKPSIALSIASALSHGQMSTRKGST+VHEFDGRFLGHHA+YKVTSVIGHVFSIDF AGFQDWKSTDPLDLFQASVIKTESNPKAHI QHL
Subjt:  MVAPTVLMVAEKPSIALSIASALSHGQMSTRKGSTEVHEFDGRFLGHHAYYKVTSVIGHVFSIDFQAGFQDWKSTDPLDLFQASVIKTESNPKAHICQHL

Query:  SREARGCDCLVLWLDCDREGENICFEVIECSGFGGNGTRKKVYRARFSSVTEKDILKALDNLVEPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYG
        SREARGCDCLVLWLDCDREGENICFEVIEC+GFGGN  RKKVYRARFSSVTEKDILKALDNLV+PN+NEALAVDARQEIDLKVGVAFTRFQTTFFQGKYG
Subjt:  SREARGCDCLVLWLDCDREGENICFEVIECSGFGGNGTRKKVYRARFSSVTEKDILKALDNLVEPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYG

Query:  NLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYILQTGYELNLDWERGKLFDCDVTAMFQKRVIEDGIAEVTEISEKQENKVRPSGLNTVNL
        NLDSRLISYGPCQTPTLGFCVQRHLQITTF PEKFWSVCPYI+Q GYELNLDWERGKLFDCDVTAMFQKRVIEDGIAEVTEISEKQENKVRPSGLNTVNL
Subjt:  NLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYILQTGYELNLDWERGKLFDCDVTAMFQKRVIEDGIAEVTEISEKQENKVRPSGLNTVNL

Query:  LKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAW
        LKVASSALGFGPQ+AMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTL+KN EWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAW
Subjt:  LKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAW

Query:  RLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAVNEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELISLMEKHG
        RLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGE+FNCTGSRV VKGFTSIMPWLAVNEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELISLMEKHG
Subjt:  RLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAVNEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELISLMEKHG

Query:  IGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVVQSVLQQFRQKYSYFVKKIDHMDALF
        IGTDASIPVHINNIGERNYVQVQAGRRL PTNLGITL+RGYQCIDPDLCLPDIRSFIE QITLVAKGQADHSSVVQ+VLQQF+QKY YFVKKIDHMDALF
Subjt:  IGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVVQSVLQQFRQKYSYFVKKIDHMDALF

Query:  EAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKGTIKLYKELTCPLDNFELLIYSLPGPEGKSFPLCPYCYNSPPFEGINTLYGA
        EAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKG IKLYKELTCPLDNFELLI+SLPGPEGKSFPLCPYCYNSPPFEGI+TLYGA
Subjt:  EAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKGTIKLYKELTCPLDNFELLIYSLPGPEGKSFPLCPYCYNSPPFEGINTLYGA

Query:  SKANPSSGTSSKGMGMPCFMCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPKGAHRISTTRDKCADCDSTIIEVDFNKKTTP
        +K NPSSG SSKGMGMPCF+C HPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLP+GAHRIST  +KCADCDSTIIEVDFNKKTTP
Subjt:  SKANPSSGTSSKGMGMPCFMCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPKGAHRISTTRDKCADCDSTIIEVDFNKKTTP

Query:  LEDGATLFVGCILCDEFLHSLLEMKHGKSFIRNRGSRGRGRGRGRGRGGRGRGSGKPMDPKMSFRDF
        LE GATLFVGCILCDEFLHSLLEMKHGKS  R RGSRGRGRGRGRG  GRGR SG+PMDPKMSFRDF
Subjt:  LEDGATLFVGCILCDEFLHSLLEMKHGKSFIRNRGSRGRGRGRGRGRGGRGRGSGKPMDPKMSFRDF

TrEMBL top hits

e value

%identity

Alignment

A0A0A0L9C7 DNA topoisomerase

0.0

99.77

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Query:  MVAPTVLMVAEKPSIALSIASALSHGQMSTRKGSTEVHEFDGRFLGHHAYYKVTSVIGHVFSIDFQAGFQDWKSTDPLDLFQASVIKTESNPKAHICQHL
        MVAPTVLMVAEKPSIALSIASALSHGQMSTRKGSTEVHEFDGRFLGHHAYYKVTSVIGHVFSIDFQAGFQDWKSTDPLDLFQASVIKTESNPKAHICQHL
Subjt:  MVAPTVLMVAEKPSIALSIASALSHGQMSTRKGSTEVHEFDGRFLGHHAYYKVTSVIGHVFSIDFQAGFQDWKSTDPLDLFQASVIKTESNPKAHICQHL

Query:  SREARGCDCLVLWLDCDREGENICFEVIECSGFGGNGTRKKVYRARFSSVTEKDILKALDNLVEPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYG
        SREARGCDCLVLWLDCDREGENICFEVIEC+GFGGNGTRKKVYRARFSSVTEKDILKALDNLVEPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYG
Subjt:  SREARGCDCLVLWLDCDREGENICFEVIECSGFGGNGTRKKVYRARFSSVTEKDILKALDNLVEPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYG

Query:  NLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYILQTGYELNLDWERGKLFDCDVTAMFQKRVIEDGIAEVTEISEKQENKVRPSGLNTVNL
        NLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYILQTGYELNLDWERGKLFDCDVTAMFQKRVIEDGIAEVTEISEKQENKVRPSGLNTVNL
Subjt:  NLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYILQTGYELNLDWERGKLFDCDVTAMFQKRVIEDGIAEVTEISEKQENKVRPSGLNTVNL

Query:  LKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAW
        LKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAW
Subjt:  LKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAW

Query:  RLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAVNEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELISLMEKHG
        RLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAVNEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELISLMEKHG
Subjt:  RLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAVNEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELISLMEKHG

Query:  IGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVVQSVLQQFRQKYSYFVKKIDHMDALF
        IGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVVQSVLQQFRQKYSYFVKKIDHMDALF
Subjt:  IGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVVQSVLQQFRQKYSYFVKKIDHMDALF

Query:  EAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKGTIKLYKELTCPLDNFELLIYSLPGPEGKSFPLCPYCYNSPPFEGINTLYGA
        EAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKGTIKLYKELTCPLDNFELLIYSLPGPEGKSFPLCPYCYNSPPFEGINTLYGA
Subjt:  EAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKGTIKLYKELTCPLDNFELLIYSLPGPEGKSFPLCPYCYNSPPFEGINTLYGA

Query:  SKANPSSGTSSKGMGMPCFMCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPKGAHRISTTRDKCADCDSTIIEVDFNKKTTP
        SKANPSSGTSSKGMGMPCFMCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPKGAHRISTTRDKCADCDSTIIEVDFNKKTTP
Subjt:  SKANPSSGTSSKGMGMPCFMCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPKGAHRISTTRDKCADCDSTIIEVDFNKKTTP

Query:  LEDGATLFVGCILCDEFLHSLLEMKHGKSFIRNRGSRGRGRGRGRGRGGRGRGSGKPMDPKMSFRDF
        LEDGATLFVGCILCDEFLHSLLEMKHGKSFIRNRGSRGRGRGRGRGRGGRGR SGKPMDPKMSFRDF
Subjt:  LEDGATLFVGCILCDEFLHSLLEMKHGKSFIRNRGSRGRGRGRGRGRGGRGRGSGKPMDPKMSFRDF

A0A1S3AYH7 DNA topoisomerase

0.0

97.35

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Query:  MVAPTVLMVAEKPSIALSIASALSHGQMSTRKGSTEVHEFDGRFLGHHAYYKVTSVIGHVFSIDFQAGFQDWKSTDPLDLFQASVIKTESNPKAHICQHL
        MVA TVLMVAEKPSIALSIASALSHGQMSTRKGSTEVHEFDGRFLGHHAYYKVTSVIGH+FSIDFQAGFQDWK+T+PLDLFQASVIKTESNPKAHI QHL
Subjt:  MVAPTVLMVAEKPSIALSIASALSHGQMSTRKGSTEVHEFDGRFLGHHAYYKVTSVIGHVFSIDFQAGFQDWKSTDPLDLFQASVIKTESNPKAHICQHL

Query:  SREARGCDCLVLWLDCDREGENICFEVIECSGFGGNGTRKKVYRARFSSVTEKDILKALDNLVEPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYG
        SREARGCDCLVLWLDCDREGENICFEVIEC+GFGGNGTRKKVYRARFSSVTEKDILKALDNLVEPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYG
Subjt:  SREARGCDCLVLWLDCDREGENICFEVIECSGFGGNGTRKKVYRARFSSVTEKDILKALDNLVEPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYG

Query:  NLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYILQTGYELNLDWERGKLFDCDVTAMFQKRVIEDGIAEVTEISEKQENKVRPSGLNTVNL
        NLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYI+Q GYELNLDWERGKLFDCDVTAMFQKRVIEDGIAEVTEISEKQENKVRPSGLNTVNL
Subjt:  NLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYILQTGYELNLDWERGKLFDCDVTAMFQKRVIEDGIAEVTEISEKQENKVRPSGLNTVNL

Query:  LKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAW
        LKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMC ATEDMLGRDAW
Subjt:  LKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAW

Query:  RLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAVNEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELISLMEKHG
        RLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAVNEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELISLMEKHG
Subjt:  RLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAVNEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELISLMEKHG

Query:  IGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVVQSVLQQFRQKYSYFVKKIDHMDALF
        IGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVV+SVLQQF+QKYSYFVKKID MDALF
Subjt:  IGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVVQSVLQQFRQKYSYFVKKIDHMDALF

Query:  EAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKGTIKLYKELTCPLDNFELLIYSLPGPEGKSFPLCPYCYNSPPFEGINTLYGA
        EAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKGTIKLYKELTCPLDNFELLI SLPGPEGKSFPLCPYCYNSPPFEGI+TLYGA
Subjt:  EAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKGTIKLYKELTCPLDNFELLIYSLPGPEGKSFPLCPYCYNSPPFEGINTLYGA

Query:  SKANPSSGTSSKGMGMPCFMCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPKGAHRISTTRDKCADCDSTIIEVDFNKKTTP
        SK NPSSGTSSKGMGMPCF+CPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLP+GAHRISTT DKCADCDSTIIEVDFNKKTTP
Subjt:  SKANPSSGTSSKGMGMPCFMCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPKGAHRISTTRDKCADCDSTIIEVDFNKKTTP

Query:  LEDGATLFVGCILCDEFLHSLLEMKHGKSFIRNRGSRGRGRGRGRGRG--GRGRGSGKPMDPKMSFRDF
        LEDGATLFVGCILCDEFLHSLLEMKHG SFIRNR SRGRGRGRGRGRG  GRGR SGKPMDPKMSFRDF
Subjt:  LEDGATLFVGCILCDEFLHSLLEMKHGKSFIRNRGSRGRGRGRGRGRG--GRGRGSGKPMDPKMSFRDF

A0A5A7VKD3 DNA topoisomerase

0.0

97.13

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Query:  MVAPTVLMVAEKPSIALSIASALSHGQMSTRKGSTEVHEFDGRFLGHHAYYKVTSVIGHVFSIDFQAGFQDWKSTDPLDLFQASVIKTESNPKAHICQHL
        MVA TVLMVAEKPSIALSIASALSHGQMSTRKGSTEVHEFDGRFLGHHAYYKVTSVIGH+FSIDFQAGFQDWK+T+PLDLFQASVIKTESNPKAHI QHL
Subjt:  MVAPTVLMVAEKPSIALSIASALSHGQMSTRKGSTEVHEFDGRFLGHHAYYKVTSVIGHVFSIDFQAGFQDWKSTDPLDLFQASVIKTESNPKAHICQHL

Query:  SREARGCDCLVLWLDCDREGENICFEVIECSGFGGNGTRKKVYRARFSSVTEKDILKALDNLVEPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYG
        SREARGCDCLVLWLDCDREGENICFEVIEC+GFGGNGTRKKVYRARFSSVTEKDILKALDNLVEPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYG
Subjt:  SREARGCDCLVLWLDCDREGENICFEVIECSGFGGNGTRKKVYRARFSSVTEKDILKALDNLVEPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYG

Query:  NLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYILQTGYELNLDWERGKLFDCDVTAMFQKRVIEDGIAEVTEISEKQENKVRPSGLNTVNL
        NLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYI+Q GYELNLDWERGKLFDCDVTAMFQKRVIEDGIAEVTEISEKQENKVRPSGLNTVNL
Subjt:  NLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYILQTGYELNLDWERGKLFDCDVTAMFQKRVIEDGIAEVTEISEKQENKVRPSGLNTVNL

Query:  LKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAW
        LKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMC ATEDMLGRDAW
Subjt:  LKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAW

Query:  RLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAVNEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELISLMEKHG
        RLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAVNEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELISLMEKHG
Subjt:  RLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAVNEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELISLMEKHG

Query:  IGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVVQSVLQQFRQKYSYFVKKIDHMDALF
        IGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVV+SVLQQF+QKYSYFVKKID MDALF
Subjt:  IGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVVQSVLQQFRQKYSYFVKKIDHMDALF

Query:  EAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKGTIKLYKELTCPLDNFELLIYSLPGPEGKSFPLCPYCYNSPPFEGINTLYGA
        EAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKGTIKLYKELTCPLDNFELLI SLPGPEGKSFPLCPYCYNSPPFEGI+TLYGA
Subjt:  EAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKGTIKLYKELTCPLDNFELLIYSLPGPEGKSFPLCPYCYNSPPFEGINTLYGA

Query:  SKANPSSGTSSKGMGMPCFMCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPKGAHRISTTRDKCADCDSTIIEVDFNKKTTP
        SK NPSSGTSSKGMGMPCF+CPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLP+GAHRISTT DKCADCDSTIIEVDFNKKTTP
Subjt:  SKANPSSGTSSKGMGMPCFMCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPKGAHRISTTRDKCADCDSTIIEVDFNKKTTP

Query:  LEDGATLFVGCILCDEFLHSLLEMKHGKSFIRNRGSRGRGRGRGRGRG----GRGRGSGKPMDPKMSFRDF
        LEDGATLFVGCILCDEFLHSLLEMKHG SFIRNR SRGRGRGRGRGRG    GRGR SGKPMDPKMSFRDF
Subjt:  LEDGATLFVGCILCDEFLHSLLEMKHGKSFIRNRGSRGRGRGRGRGRG----GRGRGSGKPMDPKMSFRDF

A0A6J1GWS0 DNA topoisomerase

0.0

93.43

Show/hide

Query:  MVAPTVLMVAEKPSIALSIASALSHGQMSTRKGSTEVHEFDGRFLGHHAYYKVTSVIGHVFSIDFQAGFQDWKSTDPLDLFQASVIKTESNPKAHICQHL
        MVA +VLMVAEKPSIALSIASALSHGQMSTRKGSTEVHEFDGRFLGHHA+YKVTSVIGHVFSIDF A FQDWK+TDPLDLFQASVIKTESNPKAHI QHL
Subjt:  MVAPTVLMVAEKPSIALSIASALSHGQMSTRKGSTEVHEFDGRFLGHHAYYKVTSVIGHVFSIDFQAGFQDWKSTDPLDLFQASVIKTESNPKAHICQHL

Query:  SREARGCDCLVLWLDCDREGENICFEVIECSGFGGNGTRKKVYRARFSSVTEKDILKALDNLVEPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYG
        SREARGCDCLVLWLDCDREGENICFEVIEC+GFGGN  RKKVYRARFSSVTEKDILKALDNLVEPNRNEALAVDARQEIDLKVGV+FTRFQTTFFQGKYG
Subjt:  SREARGCDCLVLWLDCDREGENICFEVIECSGFGGNGTRKKVYRARFSSVTEKDILKALDNLVEPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYG

Query:  NLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYILQTGYELNLDWERGKLFDCDVTAMFQKRVIEDGIAEVTEISEKQENKVRPSGLNTVNL
        NLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYI+Q GYELNLDWERG+LFDCDV  MFQKRV+EDGIAEVT+ISEKQE+KVRPSGLNTVNL
Subjt:  NLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYILQTGYELNLDWERGKLFDCDVTAMFQKRVIEDGIAEVTEISEKQENKVRPSGLNTVNL

Query:  LKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAW
        LKVASSALG+GPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLH+LVKNPEWGDYVR+LLSDGYSKPRSGTDVGDHPPITPM LATEDM+GRDAW
Subjt:  LKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAW

Query:  RLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAVNEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELISLMEKHG
        RLYQYVCQHFIGSLSSDCKY+RTKIQFSIAGEIFNCTGS V VKGFTSIMPWLAVNEKKLPQFLKG+KIEVA+VDLYQGNT+PPDYLSESELISLMEKHG
Subjt:  RLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAVNEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELISLMEKHG

Query:  IGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVVQSVLQQFRQKYSYFVKKIDHMDALF
        IGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIE QIT VAKGQADH SVVQ+VLQQF+QKYSYFVKKIDHMDALF
Subjt:  IGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVVQSVLQQFRQKYSYFVKKIDHMDALF

Query:  EAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKGTIKLYKELTCPLDNFELLIYSLPGPEGKSFPLCPYCYNSPPFEGINTLYGA
        EAQFSPLA+SGRALSKCGKCLRYMKFISSQPQRLYCG CEEVYYLPQ+G IKLYKELTCPLDNFELLI+SLPGPEGKSFPLCPYCYNSPPFEGI+TLYGA
Subjt:  EAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKGTIKLYKELTCPLDNFELLIYSLPGPEGKSFPLCPYCYNSPPFEGINTLYGA

Query:  SKANPSSGTSSKGMGMPCFMCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPKGAHRISTTRDKCADCDSTIIEVDFNKKTTP
        +K NPSSG SSKGMGMPCF+CPHPTCRHSLITQGVCACPECSGTLVLDPV APNWKLNCNKCNCLVFLP+GAHRI+TT +KCA+CDSTIIEVDFNKKTTP
Subjt:  SKANPSSGTSSKGMGMPCFMCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPKGAHRISTTRDKCADCDSTIIEVDFNKKTTP

Query:  LEDGATLFVGCILCDEFLHSLLEMKHGKSFIRNRGSRGRGRGRGRGRGGRGRGSGKPMDPKMSFRDF
        LE GATLFVGCILCDEFLHSLLEMKHGKSF R RGSRGRGRGRGRGRG RGR SGK MDPKMSFRDF
Subjt:  LEDGATLFVGCILCDEFLHSLLEMKHGKSFIRNRGSRGRGRGRGRGRGGRGRGSGKPMDPKMSFRDF

A0A6J1IRJ0 DNA topoisomerase

0.0

93.54

Show/hide

Query:  MVAPTVLMVAEKPSIALSIASALSHGQMSTRKGSTEVHEFDGRFLGHHAYYKVTSVIGHVFSIDFQAGFQDWKSTDPLDLFQASVIKTESNPKAHICQHL
        MVA +VLMVAEKPSIALSIASALSHGQMSTRKGSTEVHEFDGRFLGHHA+YKVTSVIGHVFSIDF A FQDWK+TDPLDLFQASVIKTESNPKAHI QHL
Subjt:  MVAPTVLMVAEKPSIALSIASALSHGQMSTRKGSTEVHEFDGRFLGHHAYYKVTSVIGHVFSIDFQAGFQDWKSTDPLDLFQASVIKTESNPKAHICQHL

Query:  SREARGCDCLVLWLDCDREGENICFEVIECSGFGGNGTRKKVYRARFSSVTEKDILKALDNLVEPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYG
        SREARGCDCLVLWLDCDREGENICFEVIEC+GFGGN  RKKVYRARFSSVTEKDILKALDNLVEPNRNEALAVDARQEIDLKVGV+FTRFQTTFFQGKYG
Subjt:  SREARGCDCLVLWLDCDREGENICFEVIECSGFGGNGTRKKVYRARFSSVTEKDILKALDNLVEPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYG

Query:  NLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYILQTGYELNLDWERGKLFDCDVTAMFQKRVIEDGIAEVTEISEKQENKVRPSGLNTVNL
        NLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYI+Q GYELNLDWERG+LFDCDV  MFQKRV+EDGIAEVT+ISEKQE+KVRPSGLNTVNL
Subjt:  NLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYILQTGYELNLDWERGKLFDCDVTAMFQKRVIEDGIAEVTEISEKQENKVRPSGLNTVNL

Query:  LKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAW
        LKVASSALG+GPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLH+LVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPM LATEDM+GRDAW
Subjt:  LKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAW

Query:  RLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAVNEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELISLMEKHG
        RLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGS V VKGFTSIMPWLAVNEKKLPQFLKG+KIEVA+VDLYQGNT+PPDYLSESELISLMEKHG
Subjt:  RLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAVNEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELISLMEKHG

Query:  IGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVVQSVLQQFRQKYSYFVKKIDHMDALF
        IGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIE QIT VAKGQADH SVVQ+VLQQF+QKYSYFVKKIDHMDALF
Subjt:  IGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVVQSVLQQFRQKYSYFVKKIDHMDALF

Query:  EAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKGTIKLYKELTCPLDNFELLIYSLPGPEGKSFPLCPYCYNSPPFEGINTLYGA
        EAQFSPLA+SGRALSKCGKCLRYMKFISSQPQRLYCG CEEVYYLPQ+G IKLYKELTCPLDNFELLI+SLPGPEGKSFPLCPYCYNSPPFEGI+ LYGA
Subjt:  EAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKGTIKLYKELTCPLDNFELLIYSLPGPEGKSFPLCPYCYNSPPFEGINTLYGA

Query:  SKANPSSGTSSKGMGMPCFMCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPKGAHRISTTRDKCADCDSTIIEVDFNKKTTP
        +K NPSSG SSKGMGMPCF+CPHPTCRHSLITQGVCACPECSGTLVLDPV APNWKLNCNKCNCLVFLP+GAHRI+TT +KCA+CDSTIIEVDFNKKTTP
Subjt:  SKANPSSGTSSKGMGMPCFMCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPKGAHRISTTRDKCADCDSTIIEVDFNKKTTP

Query:  LEDGATLFVGCILCDEFLHSLLEMKHGKSFIRNRGSRGRGRGRGRGRGGRGRGSGKPMDPKMSFRDF
        LE GATLFVGCILCDEFLHSLLEMKHGKSF R RGSRGRGRGRGRGRG RGR SGK MDPKMSFRDF
Subjt:  LEDGATLFVGCILCDEFLHSLLEMKHGKSFIRNRGSRGRGRGRGRGRGGRGRGSGKPMDPKMSFRDF

SwissProt top hits

e value

%identity

Alignment

F4ISQ7 DNA topoisomerase 3-beta

0.0e+00

77.15

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Query:  VLMVAEKPSIALSIASALSHGQMSTRKGSTEVHEFDGRFLGHHAYYKVTSVIGHVFSIDFQAGFQDWKSTDPLDLFQASVIKTESNPKAHICQHLSREAR
        VLMVAEKPSIALSIAS LSHGQMSTR+GSTEVHEFDG F G  A+Y+VTSVIGHVFS+DF   +Q+W + DP DLF A +IK ESNPKAHIC+HLS EAR
Subjt:  VLMVAEKPSIALSIASALSHGQMSTRKGSTEVHEFDGRFLGHHAYYKVTSVIGHVFSIDFQAGFQDWKSTDPLDLFQASVIKTESNPKAHICQHLSREAR

Query:  GCDCLVLWLDCDREGENICFEVIECSGFGGNGTRKKVYRARFSSVTEKDILKALDNLVEPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYGNLDSR
        GC  +VLWLDCDREGENICFEVIE +GF    +++KVYRARFSSVTEKDI KA+DNLVEPNR+EALAVDARQEIDLKVGVAF+RFQT++FQGKY NLD R
Subjt:  GCDCLVLWLDCDREGENICFEVIECSGFGGNGTRKKVYRARFSSVTEKDILKALDNLVEPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYGNLDSR

Query:  LISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYILQTGYELNLDWERGKLFDCDVTAMFQKRVIEDGIAEVTEISEKQENKVRPSGLNTVNLLKVAS
        +ISYGPCQTPTLGFCVQR++ I TFKPEKFW++ PYI + GYEL L+WER +LFD +   +FQK V+E   A+V ++SEKQE K RP+GLNTVNLLKVAS
Subjt:  LISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYILQTGYELNLDWERGKLFDCDVTAMFQKRVIEDGIAEVTEISEKQENKVRPSGLNTVNLLKVAS

Query:  SALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAWRLYQY
        SALGFGPQ AM LAERLYTQGFISYPRTESTAYPSSFDF  TL   V NP WG YV+ LLSDG+  P+SGTD GDHPPITPM  ATE M+G DAWRLYQY
Subjt:  SALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAWRLYQY

Query:  VCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAVNEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELISLMEKHGIGTDA
        VCQHF+G++S +CKYIRTK++ SI GE F+CTG RVT KGFT+IMPW AV+EKKLP FLKGE+IEV RV+LY+GNT PPDYL+ESELISLMEKHGIGTDA
Subjt:  VCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAVNEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELISLMEKHGIGTDA

Query:  SIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVVQSVLQQFRQKYSYFVKKIDHMDALFEAQFS
        SI VHINNIGERNYVQVQ+GR++VPT LGITLIRGYQCIDPDLCLPDIRSFIE QITLVAKGQADHS VVQ V+QQFR+K+SYFV++I+HMDALFEAQFS
Subjt:  SIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVVQSVLQQFRQKYSYFVKKIDHMDALFEAQFS

Query:  PLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKGTIKLYKELTCPLDNFELLIYSLPGPEGKSFPLCPYCYNSPPFEGINTLYGASKANP
        PLADSGRALSKCGKCLRYMK I++ P RL+CG CEEVYYLPQKGT+KLYKELTCPLDNFEL+IYS+PGPEGKSFPLCPYCYNSPPFEGI+TL+GASK   
Subjt:  PLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKGTIKLYKELTCPLDNFELLIYSLPGPEGKSFPLCPYCYNSPPFEGINTLYGASKANP

Query:  SSGTSSKGMGMPCFMCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPKGAHRISTTRDKCADCDSTIIEVDFNKKTTPLEDGA
        +   +  G GMPC +CPHPTC+HS+  QGVCACPEC GTLVLDPVS P WKLNCN C+C+V LP+GAHRI+TT ++C +CDS IIE+DFNKKTTPLE+GA
Subjt:  SSGTSSKGMGMPCFMCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPKGAHRISTTRDKCADCDSTIIEVDFNKKTTPLEDGA

Query:  TLFVGCILCDEFLHSLLEMKHGKSFIRNRGSRGRGRGRGRGRGGRGRGSGKPMDPKMSFRDF
        TL  GC+LCDE L SL+E+KHG+SF+R RG RGRGRGRGRGRGGR RGS K +DPKMSFRDF
Subjt:  TLFVGCILCDEFLHSLLEMKHGKSFIRNRGSRGRGRGRGRGRGGRGRGSGKPMDPKMSFRDF

O95985 DNA topoisomerase 3-beta-1

2.0e-265

52.65

Show/hide

Query:  TVLMVAEKPSIALSIASALSHGQMSTRK---GSTEVHEFDGRFLGHHAYYKVTSVIGHVFSIDFQAGFQDWKSTDPLDLF-QASVIKTESNPKAHICQHL
        TVLMVAEKPS+A SIA  LS G +S+ K   G+  VHE+ G F G    +K+TSV GHV ++DF   +  W   DP +LF QA   K E+NPK ++ + L
Subjt:  TVLMVAEKPSIALSIASALSHGQMSTRK---GSTEVHEFDGRFLGHHAYYKVTSVIGHVFSIDFQAGFQDWKSTDPLDLF-QASVIKTESNPKAHICQHL

Query:  SREARGCDCLVLWLDCDREGENICFEVIEC---SGFGGNGTRKKVYRARFSSVTEKDILKALDNLVEPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQG
          E RGCD +VLWLDCD+EGENICFEV++         +G  K V+RARFSS+T+ DI  A+  L EP+ NEAL+VDARQE+DL++G AFTRFQT +FQG
Subjt:  SREARGCDCLVLWLDCDREGENICFEVIEC---SGFGGNGTRKKVYRARFSSVTEKDILKALDNLVEPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQG

Query:  KYGNLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYI-LQTGYELNLDWERGKLFDCDVTAMFQKRVIEDGIAEVTEISEKQENKVRPSGLN
        KYG+LDS LIS+GPCQTPTLGFCV+RH +I +FKPE +W +   +       L LDW+R ++FD ++  MF      +  A+V   S K++ K RP  LN
Subjt:  KYGNLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYI-LQTGYELNLDWERGKLFDCDVTAMFQKRVIEDGIAEVTEISEKQENKVRPSGLN

Query:  TVNLLKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMCLATEDMLG
        TV +L+VASS+LG GPQ AMQ AERLYTQG+ISYPRTE+T YP +FD KG+L     +P W D V+ LL++G ++PR G D GDHPPITPM  ATE  LG
Subjt:  TVNLLKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMCLATEDMLG

Query:  RDAWRLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAVN-EKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELISL
         DAWRLY+Y+ +HFI ++S DCKY+++ I F I  E+F C+G  V   GFT +MPW +V  E+ LP   +G+   V  V + +  T PPDYL+E+ELI+L
Subjt:  RDAWRLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAVN-EKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELISL

Query:  MEKHGIGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVVQSVLQQFRQKYSYFVKKIDH
        MEKHGIGTDASIPVHINNI +RNYV V++GRRL PTNLGI L+ GY  ID +L LP IRS +E Q+ L+A+G+AD+  V+   L  F++K+ YFV  I  
Subjt:  MEKHGIGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVVQSVLQQFRQKYSYFVKKIDH

Query:  MDALFEAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKGTIKLYKELTCPLDNFELLIYSLPGPEGKSFPLCPYCYNSPPFEGIN
        MD L E  FSPLA +G+ LS+CGKC R+MK+I ++P RL+C  C+E Y LPQ GTIKLYKEL CPLD+FEL+++S  G  GKS+PLCPYCYN PPF  + 
Subjt:  MDALFEAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKGTIKLYKELTCPLDNFELLIYSLPGPEGKSFPLCPYCYNSPPFEGIN

Query:  TLYGASKANPSSGTSSKGMGMPCFMCPHPTCRHSLITQGVCACPEC-SGTLVLDPVSAPNWKLNCNKCNCLVFLPKGAHRISTTRDKCADCDSTIIEVDF
                        KGMG  C  C HP+C+HSL   G+  C EC SG LVLDP S P WK+ CNKCN +    + AHR+  + D C+ C++ +++VDF
Subjt:  TLYGASKANPSSGTSSKGMGMPCFMCPHPTCRHSLITQGVCACPEC-SGTLVLDPVSAPNWKLNCNKCNCLVFLPKGAHRISTTRDKCADCDSTIIEVDF

Query:  NKKTTPLEDGATLFVGCILCDEFLHSLLEMKHGKS-FIRNRGSRGRGRGRGRGRGGRGRGSGKPMDPK
        NK  +PL    T  +GC+ CD     L+E+KH  S    +RG  GR +GRGRGR  R  G   P  PK
Subjt:  NKKTTPLEDGATLFVGCILCDEFLHSLLEMKHGKS-FIRNRGSRGRGRGRGRGRGGRGRGSGKPMDPK

O96651 DNA topoisomerase 3-beta

1.3e-237

48.42

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Query:  TVLMVAEKPSIALSIASALSHGQMSTRKGS---TEVHEFDGRFLGH-HAYYKVTSVIGHVFSIDFQAGFQDWKSTDPLDLFQASVIKTESNPKAHICQHL
        +VLMVAEKPS+A S+A  LS+G+ + ++G+      HE+ G F      ++++TSV GHV S+DF   +  W   DP+ LF  +  K E+NPK ++ + L
Subjt:  TVLMVAEKPSIALSIASALSHGQMSTRKGS---TEVHEFDGRFLGH-HAYYKVTSVIGHVFSIDFQAGFQDWKSTDPLDLFQASVIKTESNPKAHICQHL

Query:  SREARGCDCLVLWLDCDREGENICFEVIECSGFGGNG--TRKKVYRARFSSVTEKDILKALDNLVEPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGK
        + EARGCD LVLWLDCD+EGENICFEV++      N   + +  YRA FS++TEKDI KA++ L  PN NEA +VDARQE+DL++G AFTRFQT FFQ +
Subjt:  SREARGCDCLVLWLDCDREGENICFEVIECSGFGGNG--TRKKVYRARFSSVTEKDILKALDNLVEPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGK

Query:  YGNLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYILQTGYELNLDWERGKLFDCDVTAMFQKRVIEDGIAEVTEISEKQENKVRPSGLNTV
        YG+LDS LISYGPCQTPTLGFCV+RH  I TFKPE FW +   +L    E+ L+W RG++F  D+  M   RV E   A V  ++ K+  K +P  LNTV
Subjt:  YGNLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYILQTGYELNLDWERGKLFDCDVTAMFQKRVIEDGIAEVTEISEKQENKVRPSGLNTV

Query:  NLLKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRD
         L+++ SS LG GP  AMQ+AERLYTQG+ISYPRTE+  YP++FD    LH L  + ++G+  R +L D    PR G D GDHPPITPM L       RD
Subjt:  NLLKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRD

Query:  AWRLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAV-NEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELISLME
         WR+Y+++C+HF+G++S D KY  T  + S+  E F+CT S +   GFT +M W A   ++  P F++G ++ +  V L +  T PPDYL+ESELI+LME
Subjt:  AWRLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAV-NEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELISLME

Query:  KHGIGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVVQSVLQQFRQKYSYFVKKIDHMD
        +HGIGTDASIPVHINNI +RNYV ++ GR+L+PT LGI L+ GYQ IDP+L LP +R+ +E  +TL+A+G A+   V++  ++ F+ K+ YFVK ID MD
Subjt:  KHGIGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVVQSVLQQFRQKYSYFVKKIDHMD

Query:  ALFEAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKGTIKLYKELTCPLDNFELLIYSLPGPEGKSFPLCPYCYNSPPFEGINTL
        ALFE  FSPLA+SG+A S+CGKC RYMK+I ++P RL+C  C+E Y LP  G +K+Y+E  CPLD+F+LL +S  G +G+S+P CPYCYN PPF  +  L
Subjt:  ALFEAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKGTIKLYKELTCPLDNFELLIYSLPGPEGKSFPLCPYCYNSPPFEGINTL

Query:  YGASKANPSSGTSSKGMGMPCFMCPHPTCRHSLITQGVCACPEC-SGTLVLDPVSAPNWKLNCNKCNCLVFLPKGAHRISTTRDKCADCDSTIIEVDFNK
         G                  C  C +  C HSL T G+ +C EC +G LVLD   AP WKL CN+C+ ++   KGA +I+    KC +C +  + V +  
Subjt:  YGASKANPSSGTSSKGMGMPCFMCPHPTCRHSLITQGVCACPEC-SGTLVLDPVSAPNWKLNCNKCNCLVFLPKGAHRISTTRDKCADCDSTIIEVDFNK

Query:  KTTPLEDGATLFVGCILCDEFLHSLLEMKHGKSFIRNRGSRGRGRGRGRGRGGRGRG
          +  +DG+    GCI C      L+E KH     R   S G  RG   GRGG G G
Subjt:  KTTPLEDGATLFVGCILCDEFLHSLLEMKHGKSFIRNRGSRGRGRGRGRGRGGRGRG

Q0J0S6 DNA topoisomerase 3-beta

0.0e+00

73.16

Show/hide

Query:  VAPTVLMVAEKPSIALSIASALSHGQMSTRKGSTEVHEFDGRFLGHHAYYKVTSVIGHVFSIDFQAGFQDWKSTDPLDLFQASVIKTESNPKAHICQHLS
        +APTVLMVAEKPSIALSIASALS G+MSTRKGST+VHEFDG F G HA++KVTSVIGHV S+DF   +Q+W+ TDP+DLF A V+++E NPKAHI +HL+
Subjt:  VAPTVLMVAEKPSIALSIASALSHGQMSTRKGSTEVHEFDGRFLGHHAYYKVTSVIGHVFSIDFQAGFQDWKSTDPLDLFQASVIKTESNPKAHICQHLS

Query:  REARGCDCLVLWLDCDREGENICFEVIECSGFGGNGTRKKVYRARFSSVTEKDILKALDNLVEPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYGN
        +EARGC  LVLWLDCDREGENIC+EVI+C+G   +   ++++RA+FSSVTEKDI+ A++NLV P+++EALAVDARQEIDLKVGVAFTRFQT +FQGKYGN
Subjt:  REARGCDCLVLWLDCDREGENICFEVIECSGFGGNGTRKKVYRARFSSVTEKDILKALDNLVEPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYGN

Query:  LDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYILQTGYELNLDWERGKLFDCDVTAMFQKRVIEDGIAEVTEISEKQENKVRPSGLNTVNLL
        LDSR+ISYGPCQTPTLGFCVQR+ QITTFKPEKFWS+  Y+++ G E+ L+W+R KLFD DVT MFQK V  DGI +VT+IS K+E K RP GLNTVNLL
Subjt:  LDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYILQTGYELNLDWERGKLFDCDVTAMFQKRVIEDGIAEVTEISEKQENKVRPSGLNTVNLL

Query:  KVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAWR
        KVASSALG GPQ AM LAERLYTQGFISYPRTESTAYPSSFDF+  L  L  NP W + VR LL  G+ KP+ G D GDHPPITPM LATE+ LG DAWR
Subjt:  KVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAWR

Query:  LYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAVNEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELISLMEKHGI
        LYQY+CQHFIG++S DC+Y RT I+F+  GE F+C G+RVT KGFTSIMPWLAV+E  +P + KG+ + + +VD+Y+G+TTPPDYLSESELISLMEK+GI
Subjt:  LYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAVNEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELISLMEKHGI

Query:  GTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVVQSVLQQFRQKYSYFVKKIDHMDALFE
        GTDASIPVH+NNI ERNYVQV +GRRLVPT LG TLIRGYQCID DLCLPDIR FIE QITL+AKG+ADH  VVQ VLQQF +KYSYFVKKI++MDALFE
Subjt:  GTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVVQSVLQQFRQKYSYFVKKIDHMDALFE

Query:  AQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKGTIKLYKELTCPLDNFELLIYSLPGPEGKSFPLCPYCYNSPPFEGINTLYGAS
        AQFSPLADSGR LSKCGKC RYMK+IS+QP RLYC  CEEVYYLPQ G+IKLYKE+ CPLD FELL++S+ GP+ KSFPLCP+CYNSPPFEGI+ L+GA 
Subjt:  AQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKGTIKLYKELTCPLDNFELLIYSLPGPEGKSFPLCPYCYNSPPFEGINTLYGAS

Query:  KANPSSGTSSKGMGMPCFMCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPKGAHRISTTRDKCADCDSTIIEVDFNKKTTPL
        K +  +G   KG GMPCF+C HPTC+ S+ITQGVCACPEC+GTL+LDPVSAP W+L CN+CNC+V LP  AH+ISTT  KC  C+STIIEVDFNKKTTPL
Subjt:  KANPSSGTSSKGMGMPCFMCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPKGAHRISTTRDKCADCDSTIIEVDFNKKTTPL

Query:  EDGATLFVGCILCDEFLHSLLEMKHGKSFIRNRGSRGRGRGRGRGRG-GRG-RGSGKPMDPKMSFRDF
        +DGATL  GCILCDE LHSL+EMKHGKSF   RG RGRGRGRGRGRG  RG RGS +  DPKMSFRDF
Subjt:  EDGATLFVGCILCDEFLHSLLEMKHGKSFIRNRGSRGRGRGRGRGRG-GRG-RGSGKPMDPKMSFRDF

Q9Z321 DNA topoisomerase 3-beta-1

3.0e-266

53.28

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Query:  TVLMVAEKPSIALSIASALSHGQMSTRK---GSTEVHEFDGRFLGHHAYYKVTSVIGHVFSIDFQAGFQDWKSTDPLDLF-QASVIKTESNPKAHICQHL
        TVLMVAEKPS+A SIA  LS G MS+ K   G+  VH++ G F G   ++K+TSV GHV ++DF   +  W   DP +LF QA   K E+NPK ++ + L
Subjt:  TVLMVAEKPSIALSIASALSHGQMSTRK---GSTEVHEFDGRFLGHHAYYKVTSVIGHVFSIDFQAGFQDWKSTDPLDLF-QASVIKTESNPKAHICQHL

Query:  SREARGCDCLVLWLDCDREGENICFEVIEC----SGFGGNGTRKKVYRARFSSVTEKDILKALDNLVEPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQ
          E RGCD +VLWLDCD+EGENICFEV++          NG  K V+RARFSS+T+ DI  A+  L EP+ NEAL+VDARQE+DL++G AFTRFQT +FQ
Subjt:  SREARGCDCLVLWLDCDREGENICFEVIEC----SGFGGNGTRKKVYRARFSSVTEKDILKALDNLVEPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQ

Query:  GKYGNLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYILQTGYE-LNLDWERGKLFDCDVTAMFQKRVIEDGIAEVTEISEKQENKVRPSGL
        GKYG+LDS LIS+GPCQTPTLGFCV+RH +I +FKPE +W +   +     E L LDW+R ++FD ++  MF      +  A V   S K++ K RP  L
Subjt:  GKYGNLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYILQTGYE-LNLDWERGKLFDCDVTAMFQKRVIEDGIAEVTEISEKQENKVRPSGL

Query:  NTVNLLKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMCLATEDML
        NTV +L+VASSALG GPQ AMQ+AERLYTQG+ISYPRTE+T YP +FD KG+L     +P W D V+ LL++G ++PR G D GDHPPITPM  ATE  L
Subjt:  NTVNLLKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMCLATEDML

Query:  GRDAWRLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAVN-EKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELIS
        G DAWRLY+Y+ +HFI ++S DCKY+++ I F I  E F C G  V   GFT IMPW +V  E+ LP   KG+   V  V + +  T+PPDYL+E+ELI+
Subjt:  GRDAWRLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAVN-EKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELIS

Query:  LMEKHGIGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVVQSVLQQFRQKYSYFVKKID
        LMEKHGIGTDASIPVHINNI +RNYV V++GRRL PTNLGI L+ GY  ID +L LP IRS +E Q+ L+A+G+AD+  V+   L  F++K+ YFV  I 
Subjt:  LMEKHGIGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVVQSVLQQFRQKYSYFVKKID

Query:  HMDALFEAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKGTIKLYKELTCPLDNFELLIYSLPGPEGKSFPLCPYCYNSPPFEGI
         MD L E  FSPLA +G+ LS+CGKC R+MK+I ++P RL+C  C+E Y LPQ GTIKLYKEL CPLD+FEL+++S  G  GKS+PLCPYCYN PPF  +
Subjt:  HMDALFEAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKGTIKLYKELTCPLDNFELLIYSLPGPEGKSFPLCPYCYNSPPFEGI

Query:  NTLYGASKANPSSGTSSKGMGMPCFMCPHPTCRHSLITQGVCACPEC-SGTLVLDPVSAPNWKLNCNKCNCLVFLPKGAHRISTTRDKCADCDSTIIEVD
                         KGMG  C  C HPTC+HSL   G+  C EC +G LVLDP S P WK+ CN CN +    + AHR+  + D C  C++ +++VD
Subjt:  NTLYGASKANPSSGTSSKGMGMPCFMCPHPTCRHSLITQGVCACPEC-SGTLVLDPVSAPNWKLNCNKCNCLVFLPKGAHRISTTRDKCADCDSTIIEVD

Query:  FNKKTTPLEDGATLFVGCILCDEFLHSLLEMKHGKS-FIRNRGSRGRGRGRGRGRGGRGRGSGKPMDPK
        FNK  +PL    T   GCI CD     L+E+KH  S    +RG  GR +GRGRGRG R  G   P  PK
Subjt:  FNKKTTPLEDGATLFVGCILCDEFLHSLLEMKHGKS-FIRNRGSRGRGRGRGRGRGGRGRGSGKPMDPK

Arabidopsis top hits

e value

%identity

Alignment

AT2G32000.1 DNA topoisomerase, type IA, core

0.0e+00

77.15

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Query:  VLMVAEKPSIALSIASALSHGQMSTRKGSTEVHEFDGRFLGHHAYYKVTSVIGHVFSIDFQAGFQDWKSTDPLDLFQASVIKTESNPKAHICQHLSREAR
        VLMVAEKPSIALSIAS LSHGQMSTR+GSTEVHEFDG F G  A+Y+VTSVIGHVFS+DF   +Q+W + DP DLF A +IK ESNPKAHIC+HLS EAR
Subjt:  VLMVAEKPSIALSIASALSHGQMSTRKGSTEVHEFDGRFLGHHAYYKVTSVIGHVFSIDFQAGFQDWKSTDPLDLFQASVIKTESNPKAHICQHLSREAR

Query:  GCDCLVLWLDCDREGENICFEVIECSGFGGNGTRKKVYRARFSSVTEKDILKALDNLVEPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYGNLDSR
        GC  +VLWLDCDREGENICFEVIE +GF    +++KVYRARFSSVTEKDI KA+DNLVEPNR+EALAVDARQEIDLKVGVAF+RFQT++FQGKY NLD R
Subjt:  GCDCLVLWLDCDREGENICFEVIECSGFGGNGTRKKVYRARFSSVTEKDILKALDNLVEPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYGNLDSR

Query:  LISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYILQTGYELNLDWERGKLFDCDVTAMFQKRVIEDGIAEVTEISEKQENKVRPSGLNTVNLLKVAS
        +ISYGPCQTPTLGFCVQR++ I TFKPEKFW++ PYI + GYEL L+WER +LFD +   +FQK V+E   A+V ++SEKQE K RP+GLNTVNLLKVAS
Subjt:  LISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYILQTGYELNLDWERGKLFDCDVTAMFQKRVIEDGIAEVTEISEKQENKVRPSGLNTVNLLKVAS

Query:  SALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAWRLYQY
        SALGFGPQ AM LAERLYTQGFISYPRTESTAYPSSFDF  TL   V NP WG YV+ LLSDG+  P+SGTD GDHPPITPM  ATE M+G DAWRLYQY
Subjt:  SALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAWRLYQY

Query:  VCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAVNEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELISLMEKHGIGTDA
        VCQHF+G++S +CKYIRTK++ SI GE F+CTG RVT KGFT+IMPW AV+EKKLP FLKGE+IEV RV+LY+GNT PPDYL+ESELISLMEKHGIGTDA
Subjt:  VCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAVNEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELISLMEKHGIGTDA

Query:  SIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVVQSVLQQFRQKYSYFVKKIDHMDALFEAQFS
        SI VHINNIGERNYVQVQ+GR++VPT LGITLIRGYQCIDPDLCLPDIRSFIE QITLVAKGQADHS VVQ V+QQFR+K+SYFV++I+HMDALFEAQFS
Subjt:  SIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVVQSVLQQFRQKYSYFVKKIDHMDALFEAQFS

Query:  PLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKGTIKLYKELTCPLDNFELLIYSLPGPEGKSFPLCPYCYNSPPFEGINTLYGASKANP
        PLADSGRALSKCGKCLRYMK I++ P RL+CG CEEVYYLPQKGT+KLYKELTCPLDNFEL+IYS+PGPEGKSFPLCPYCYNSPPFEGI+TL+GASK   
Subjt:  PLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKGTIKLYKELTCPLDNFELLIYSLPGPEGKSFPLCPYCYNSPPFEGINTLYGASKANP

Query:  SSGTSSKGMGMPCFMCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPKGAHRISTTRDKCADCDSTIIEVDFNKKTTPLEDGA
        +   +  G GMPC +CPHPTC+HS+  QGVCACPEC GTLVLDPVS P WKLNCN C+C+V LP+GAHRI+TT ++C +CDS IIE+DFNKKTTPLE+GA
Subjt:  SSGTSSKGMGMPCFMCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPKGAHRISTTRDKCADCDSTIIEVDFNKKTTPLEDGA

Query:  TLFVGCILCDEFLHSLLEMKHGKSFIRNRGSRGRGRGRGRGRGGRGRGSGKPMDPKMSFRDF
        TL  GC+LCDE L SL+E+KHG+SF+R RG RGRGRGRGRGRGGR RGS K +DPKMSFRDF
Subjt:  TLFVGCILCDEFLHSLLEMKHGKSFIRNRGSRGRGRGRGRGRGGRGRGSGKPMDPKMSFRDF

AT2G32000.2 DNA topoisomerase, type IA, core

0.0e+00

76.11

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Query:  HVFSI---DFQAGFQDWKSTDPLDLFQASVIKTESNPKAHICQHLSREARGCDCLVLWLDCDREGENICFEVIECSGFGGNGTRKKVYRARFSSVTEKDI
        H+ S+   DF   +Q+W + DP DLF A +IK ESNPKAHIC+HLS EARGC  +VLWLDCDREGENICFEVIE +GF    +++KVYRARFSSVTEKDI
Subjt:  HVFSI---DFQAGFQDWKSTDPLDLFQASVIKTESNPKAHICQHLSREARGCDCLVLWLDCDREGENICFEVIECSGFGGNGTRKKVYRARFSSVTEKDI

Query:  LKALDNLVEPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYGNLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYILQTGYELNLDWER
         KA+DNLVEPNR+EALAVDARQEIDLKVGVAF+RFQT++FQGKY NLD R+ISYGPCQTPTLGFCVQR++ I TFKPEKFW++ PYI + GYEL L+WER
Subjt:  LKALDNLVEPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYGNLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYILQTGYELNLDWER

Query:  GKLFDCDVTAMFQKRVIEDGIAEVTEISEKQENKVRPSGLNTVNLLKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNP
         +LFD +   +FQK V+E   A+V ++SEKQE K RP+GLNTVNLLKVASSALGFGPQ AM LAERLYTQGFISYPRTESTAYPSSFDF  TL   V NP
Subjt:  GKLFDCDVTAMFQKRVIEDGIAEVTEISEKQENKVRPSGLNTVNLLKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNP

Query:  EWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAWRLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAV
         WG YV+ LLSDG+  P+SGTD GDHPPITPM  ATE M+G DAWRLYQYVCQHF+G++S +CKYIRTK++ SI GE F+CTG RVT KGFT+IMPW AV
Subjt:  EWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAWRLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAV

Query:  NEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELISLMEKHGIGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRS
        +EKKLP FLKGE+IEV RV+LY+GNT PPDYL+ESELISLMEKHGIGTDASI VHINNIGERNYVQVQ+GR++VPT LGITLIRGYQCIDPDLCLPDIRS
Subjt:  NEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELISLMEKHGIGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRS

Query:  FIEHQITLVAKGQADHSSVVQSVLQQFRQKYSYFVKKIDHMDALFEAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKGTIKLYK
        FIE QITLVAKGQADHS VVQ V+QQFR+K+SYFV++I+HMDALFEAQFSPLADSGRALSKCGKCLRYMK I++ P RL+CG CEEVYYLPQKGT+KLYK
Subjt:  FIEHQITLVAKGQADHSSVVQSVLQQFRQKYSYFVKKIDHMDALFEAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKGTIKLYK

Query:  ELTCPLDNFELLIYSLPGPEGKSFPLCPYCYNSPPFEGINTLYGASKANPSSGTSSKGMGMPCFMCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNW
        ELTCPLDNFEL+IYS+PGPEGKSFPLCPYCYNSPPFEGI+TL+GASK   +   +  G GMPC +CPHPTC+HS+  QGVCACPEC GTLVLDPVS P W
Subjt:  ELTCPLDNFELLIYSLPGPEGKSFPLCPYCYNSPPFEGINTLYGASKANPSSGTSSKGMGMPCFMCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNW

Query:  KLNCNKCNCLVFLPKGAHRISTTRDKCADCDSTIIEVDFNKKTTPLEDGATLFVGCILCDEFLHSLLEMKHGKSFIRNRGSRGRGRGRGRGRGGRGRGSG
        KLNCN C+C+V LP+GAHRI+TT ++C +CDS IIE+DFNKKTTPLE+GATL  GC+LCDE L SL+E+KHG+SF+R RG RGRGRGRGRGRGGR RGS 
Subjt:  KLNCNKCNCLVFLPKGAHRISTTRDKCADCDSTIIEVDFNKKTTPLEDGATLFVGCILCDEFLHSLLEMKHGKSFIRNRGSRGRGRGRGRGRGGRGRGSG

Query:  KPMDPKMSFRDF
        K +DPKMSFRDF
Subjt:  KPMDPKMSFRDF

AT5G63920.1 topoisomerase 3alpha

2.6e-111

36.72

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Query:  TVLMVAEKPSIALSIASALSHGQMSTRKGST---EVHEFDGRFLGHHAYYKVTSVIGHVFSIDFQAGFQDWKSTDPLDLFQASVIKTESNPKAHICQHLS
        TVL VAEKPS+A S+A  LS G   TR+G +   ++ EFD    G      +TSVIGH+  ++F   ++ W S DP DL+QA V+K     K  I + L 
Subjt:  TVLMVAEKPSIALSIASALSHGQMSTRKGST---EVHEFDGRFLGHHAYYKVTSVIGHVFSIDFQAGFQDWKSTDPLDLFQASVIKTESNPKAHICQHLS

Query:  REARGCDCLVLWLDCDREGENICFEVIE-CSGFGGNGTRKKVYRARFSSVTEKDILKALDNLVEPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKY-
         EAR  D LVLWLDCDREGENI FEV++ C     N     + RA FS++ ++DI +A+ NL +PN+  A AVDARQEIDL++G +FTRFQT   + ++ 
Subjt:  REARGCDCLVLWLDCDREGENICFEVIE-CSGFGGNGTRKKVYRARFSSVTEKDILKALDNLVEPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKY-

Query:  ----GNLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSV-CPYILQTGYELNLDWERGKLFDCDVTAMFQKRVIEDGIAEVTEISEKQEN-KVRPS
            G   SR+ISYGPCQ PTLGF V+R+ +I   +PE+FW++ C +  + G     +W RG LFD     +  +  +E+  A V  +   +E  K  P 
Subjt:  ----GNLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSV-CPYILQTGYELNLDWERGKLFDCDVTAMFQKRVIEDGIAEVTEISEKQEN-KVRPS

Query:  GLNTVNLLKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSD----GYSKPRSGTDVGDHPPITPMCL
         LNT+ L K AS       +  M++AE LY  GFISYPRTE+ ++ S  D +  +    ++P WG Y + LL        +    G D   HPPI P   
Subjt:  GLNTVNLLKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSD----GYSKPRSGTDVGDHPPITPMCL

Query:  AT-EDMLGRDAWRLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAVNEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLS
        ++ E    RD   +Y+ V +H++  +S       T ++  IAGE F+ +G  +  K +  +  + +     +P + KG++     + L    T PP  L 
Subjt:  AT-EDMLGRDAWRLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAVNEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLS

Query:  ESELISLMEKHGIGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVVQSVLQQFRQKY-S
        E++L+S M+K GIGTDA++  HI  + +R Y    A  R  PTNLG  L+ GY  +  +L  P++R+ +EH +  V+ G+   + V+++ LQQ +  +  
Subjt:  ESELISLMEKHGIGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVVQSVLQQFRQKY-S

Query:  YFVKK---IDHMDALFE----AQFSPLADSGRALSKCGKC
          VKK   ++ M   FE       S    +G  + +C  C
Subjt:  YFVKK---IDHMDALFE----AQFSPLADSGRALSKCGKC

Sequences

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CDS sequence

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CCTCTCCTCCTCCATTGTGGCTCTGTTCATTTCCAGTTGAAGTCGAAGCTTCTGCTCAACGATTGTGAAGTTTCACTCAGAAAGTCGCTGAACTCAGCCGTTCAGGTTCC
GGCGACAACCCTAATCATGGTTGCTCCAACGGTTCTTATGGTTGCAGAGAAGCCTAGCATTGCGCTTTCAATTGCTTCTGCACTCTCCCATGGCCAAATGTCTACAAGAA
AGGGCAGCACAGAGGTACATGAATTTGACGGGAGATTTCTTGGGCATCATGCTTATTATAAAGTGACATCTGTTATCGGACATGTTTTCAGTATAGATTTCCAAGCTGGA
TTTCAAGATTGGAAGAGCACCGATCCTTTGGATCTTTTTCAAGCTTCAGTAATTAAGACAGAATCAAACCCAAAGGCTCACATATGTCAACATTTAAGTCGAGAAGCGCG
TGGTTGTGATTGTTTGGTTTTATGGTTGGATTGTGATCGCGAAGGAGAAAATATTTGTTTTGAAGTTATTGAGTGCTCTGGATTTGGTGGCAATGGAACAAGGAAAAAAG
TGTATCGTGCAAGGTTTTCTTCTGTTACTGAGAAAGATATTCTGAAGGCTTTGGATAACCTTGTTGAACCTAATAGAAACGAGGCACTTGCTGTTGATGCTCGACAAGAG
ATAGATTTGAAAGTTGGAGTAGCCTTTACACGATTTCAGACTACCTTTTTTCAGGGAAAATATGGAAACCTCGATTCCAGACTCATTTCCTATGGACCATGCCAAACTCC
CACGCTTGGGTTTTGTGTACAGCGTCATTTGCAAATAACCACCTTTAAACCAGAAAAATTTTGGTCTGTATGCCCTTATATTCTGCAAACCGGCTATGAACTTAATTTGG
ACTGGGAACGTGGCAAGTTATTCGACTGTGATGTTACTGCAATGTTTCAAAAACGAGTAATAGAAGATGGAATTGCAGAAGTAACAGAAATATCAGAGAAGCAAGAAAAC
AAAGTTCGACCTTCTGGACTAAATACAGTTAACCTTCTGAAGGTTGCTTCAAGTGCACTAGGATTTGGACCTCAAATGGCAATGCAACTAGCTGAACGATTGTATACGCA
AGGATTCATCAGCTATCCACGTACAGAAAGTACGGCTTATCCTTCTTCGTTTGACTTCAAAGGCACTCTACATACCCTAGTGAAAAATCCAGAATGGGGTGATTATGTAC
GGATGCTTCTGTCTGATGGATACAGTAAACCACGATCAGGAACTGACGTGGGTGATCATCCTCCCATTACTCCAATGTGTTTAGCAACAGAAGATATGTTAGGGAGAGAT
GCTTGGAGATTGTACCAATATGTGTGTCAACATTTCATTGGATCTCTGTCTTCTGACTGCAAGTATATTAGGACGAAGATACAGTTTTCAATCGCTGGAGAAATATTCAA
CTGTACTGGGTCACGTGTTACAGTAAAAGGATTCACCTCCATTATGCCATGGTTGGCAGTAAATGAAAAAAAACTACCTCAGTTTCTGAAGGGAGAGAAAATTGAAGTTG
CAAGAGTGGATCTTTATCAGGGGAATACCACACCTCCGGATTATTTAAGTGAAAGTGAGTTGATTTCTCTCATGGAGAAGCATGGAATAGGCACAGATGCATCAATACCC
GTACACATTAACAACATAGGCGAGCGCAACTATGTTCAGGTTCAAGCTGGGAGGAGGTTGGTTCCAACTAACTTGGGCATCACCTTAATTAGAGGATATCAATGCATTGA
TCCAGATCTCTGTTTACCAGATATTCGAAGTTTCATCGAGCATCAGATCACTCTTGTTGCCAAAGGTCAAGCAGATCATTCTAGTGTTGTGCAGAGTGTATTGCAACAGT
TCAGGCAAAAGTATAGCTACTTTGTTAAGAAGATTGATCATATGGATGCTCTGTTTGAAGCACAATTTTCTCCCCTTGCCGATTCAGGACGTGCTTTGAGCAAATGTGGA
AAGTGCCTACGGTATATGAAGTTTATTTCTTCCCAACCACAGCGTCTGTACTGTGGTATATGTGAGGAGGTTTATTATCTTCCTCAAAAGGGAACAATAAAGCTGTATAA
GGAACTTACATGCCCTCTGGACAACTTTGAGCTCTTGATTTATTCCTTACCTGGCCCAGAAGGCAAGTCATTTCCTCTTTGCCCATATTGCTACAATAGTCCTCCATTTG
AGGGTATCAACACATTATATGGTGCTTCTAAAGCCAACCCAAGTTCCGGAACATCAAGCAAGGGAATGGGCATGCCATGCTTCATGTGTCCACACCCAACATGTCGACAT
TCTTTAATAACCCAAGGAGTTTGCGCTTGTCCAGAATGTAGCGGGACACTTGTCCTAGATCCTGTGAGTGCACCCAACTGGAAACTCAACTGCAACAAATGCAATTGTCT
TGTCTTCCTTCCTAAAGGTGCTCATAGGATTTCCACCACACGTGACAAGTGTGCTGATTGTGACTCTACAATTATAGAAGTTGACTTCAACAAGAAAACGACACCATTGG
AGGATGGAGCTACACTGTTTGTTGGATGCATTCTTTGCGATGAGTTTCTCCATTCACTTCTGGAGATGAAGCATGGAAAATCATTTATCAGAAACAGAGGTTCGAGAGGA
AGAGGAAGGGGAAGAGGACGGGGAAGGGGAGGAAGAGGACGTGGTTCAGGGAAACCAATGGACCCAAAAATGAGTTTCCGAGACTTCTGA

mRNA sequence

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Protein sequence

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PLLLHCGSVHFQLKSKLLLNDCEVSLRKSLNSAVQVPATTLIMVAPTVLMVAEKPSIALSIASALSHGQMSTRKGSTEVHEFDGRFLGHHAYYKVTSVIGHVFSIDFQAG
FQDWKSTDPLDLFQASVIKTESNPKAHICQHLSREARGCDCLVLWLDCDREGENICFEVIECSGFGGNGTRKKVYRARFSSVTEKDILKALDNLVEPNRNEALAVDARQE
IDLKVGVAFTRFQTTFFQGKYGNLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYILQTGYELNLDWERGKLFDCDVTAMFQKRVIEDGIAEVTEISEKQEN
KVRPSGLNTVNLLKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRD
AWRLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAVNEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELISLMEKHGIGTDASIP
VHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVVQSVLQQFRQKYSYFVKKIDHMDALFEAQFSPLADSGRALSKCG
KCLRYMKFISSQPQRLYCGICEEVYYLPQKGTIKLYKELTCPLDNFELLIYSLPGPEGKSFPLCPYCYNSPPFEGINTLYGASKANPSSGTSSKGMGMPCFMCPHPTCRH
SLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPKGAHRISTTRDKCADCDSTIIEVDFNKKTTPLEDGATLFVGCILCDEFLHSLLEMKHGKSFIRNRGSRG
RGRGRGRGRGGRGRGSGKPMDPKMSFRDF

Cucsat.G603 (gene) of Cucumber (B10) v3 genome