CuGenDBv2

Gene ID	HG10003828
Organism	Lagenaria siceraria cv. Hangzhou Gourd (Bottle gourd (Hangzhou Gourd) v1)
Description	Non-specific serine/threonine protein kinase
Genome location	Chr08:9862577..9869064
RNA-Seq Expression	HG10003828
Synteny	HG10003828
Gene Ontology terms	GO:0006521 - regulation of cellular amino acid metabolic process (biological process) GO:0009635 - response to herbicide (biological process) GO:0010998 - regulation of translational initiation by eIF2 alpha phosphorylation (biological process) GO:0018105 - peptidyl-serine phosphorylation (biological process) GO:0005886 - plasma membrane (cellular component) GO:0000049 - tRNA binding (molecular function) GO:0004694 - eukaryotic translation initiation factor 2alpha kinase activity (molecular function) GO:0004712 - protein serine/threonine/tyrosine kinase activity (molecular function) GO:0005524 - ATP binding (molecular function) GO:0106310 - protein serine kinase activity (molecular function)
InterPro domains	NA

Homology

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GenBank top hits

e value

%identity

Alignment

XP_008445744.1 PREDICTED: eIF-2-alpha kinase GCN2 isoform X4 [Cucumis melo]

5.7e-55

97.35

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Query:  MKSSEDSSIYDRVVNAIFDEETLVMKDDRHDCGTAPIQYTDLGTEVRDHVIDATREMFRLHCAKHLEISSMYLLDGSTQINRNTVKLLSHGGDILELCHE
        MK SEDSSIYDRVVNAIFDEETLVMKDDRHDC TA IQYTDLGTEVRDHVIDATREMFRLHCAKHLEISSMYLLDGSTQINRNTVKLLSHGGDILELCHE
Subjt:  MKSSEDSSIYDRVVNAIFDEETLVMKDDRHDCGTAPIQYTDLGTEVRDHVIDATREMFRLHCAKHLEISSMYLLDGSTQINRNTVKLLSHGGDILELCHE

Query:  LRLPFLNWLVSSQ
        LRLPFLNWLVSSQ
Subjt:  LRLPFLNWLVSSQ

XP_038885257.1 eIF-2-alpha kinase GCN2 isoform X1 [Benincasa hispida]

9.4e-58

100

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Query:  MKSSEDSSIYDRVVNAIFDEETLVMKDDRHDCGTAPIQYTDLGTEVRDHVIDATREMFRLHCAKHLEISSMYLLDGSTQINRNTVKLLSHGGDILELCHE
        MKSSEDSSIYDRVVNAIFDEETLVMKDDRHDCGTAPIQYTDLGTEVRDHVIDATREMFRLHCAKHLEISSMYLLDGSTQINRNTVKLLSHGGDILELCHE
Subjt:  MKSSEDSSIYDRVVNAIFDEETLVMKDDRHDCGTAPIQYTDLGTEVRDHVIDATREMFRLHCAKHLEISSMYLLDGSTQINRNTVKLLSHGGDILELCHE

Query:  LRLPFLNWLVSSQ
        LRLPFLNWLVSSQ
Subjt:  LRLPFLNWLVSSQ

XP_038885258.1 eIF-2-alpha kinase GCN2 isoform X2 [Benincasa hispida]

9.4e-58

100

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Query:  MKSSEDSSIYDRVVNAIFDEETLVMKDDRHDCGTAPIQYTDLGTEVRDHVIDATREMFRLHCAKHLEISSMYLLDGSTQINRNTVKLLSHGGDILELCHE
        MKSSEDSSIYDRVVNAIFDEETLVMKDDRHDCGTAPIQYTDLGTEVRDHVIDATREMFRLHCAKHLEISSMYLLDGSTQINRNTVKLLSHGGDILELCHE
Subjt:  MKSSEDSSIYDRVVNAIFDEETLVMKDDRHDCGTAPIQYTDLGTEVRDHVIDATREMFRLHCAKHLEISSMYLLDGSTQINRNTVKLLSHGGDILELCHE

Query:  LRLPFLNWLVSSQ
        LRLPFLNWLVSSQ
Subjt:  LRLPFLNWLVSSQ

XP_038885259.1 eIF-2-alpha kinase GCN2 isoform X3 [Benincasa hispida]

9.4e-58

100

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Query:  MKSSEDSSIYDRVVNAIFDEETLVMKDDRHDCGTAPIQYTDLGTEVRDHVIDATREMFRLHCAKHLEISSMYLLDGSTQINRNTVKLLSHGGDILELCHE
        MKSSEDSSIYDRVVNAIFDEETLVMKDDRHDCGTAPIQYTDLGTEVRDHVIDATREMFRLHCAKHLEISSMYLLDGSTQINRNTVKLLSHGGDILELCHE
Subjt:  MKSSEDSSIYDRVVNAIFDEETLVMKDDRHDCGTAPIQYTDLGTEVRDHVIDATREMFRLHCAKHLEISSMYLLDGSTQINRNTVKLLSHGGDILELCHE

Query:  LRLPFLNWLVSSQ
        LRLPFLNWLVSSQ
Subjt:  LRLPFLNWLVSSQ

XP_038885260.1 eIF-2-alpha kinase GCN2 isoform X4 [Benincasa hispida]

9.4e-58

100

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Query:  MKSSEDSSIYDRVVNAIFDEETLVMKDDRHDCGTAPIQYTDLGTEVRDHVIDATREMFRLHCAKHLEISSMYLLDGSTQINRNTVKLLSHGGDILELCHE
        MKSSEDSSIYDRVVNAIFDEETLVMKDDRHDCGTAPIQYTDLGTEVRDHVIDATREMFRLHCAKHLEISSMYLLDGSTQINRNTVKLLSHGGDILELCHE
Subjt:  MKSSEDSSIYDRVVNAIFDEETLVMKDDRHDCGTAPIQYTDLGTEVRDHVIDATREMFRLHCAKHLEISSMYLLDGSTQINRNTVKLLSHGGDILELCHE

Query:  LRLPFLNWLVSSQ
        LRLPFLNWLVSSQ
Subjt:  LRLPFLNWLVSSQ

TrEMBL top hits

e value

%identity

Alignment

A0A1S3BCY3 Non-specific serine/threonine protein kinase

2.7e-55

97.35

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Query:  MKSSEDSSIYDRVVNAIFDEETLVMKDDRHDCGTAPIQYTDLGTEVRDHVIDATREMFRLHCAKHLEISSMYLLDGSTQINRNTVKLLSHGGDILELCHE
        MK SEDSSIYDRVVNAIFDEETLVMKDDRHDC TA IQYTDLGTEVRDHVIDATREMFRLHCAKHLEISSMYLLDGSTQINRNTVKLLSHGGDILELCHE
Subjt:  MKSSEDSSIYDRVVNAIFDEETLVMKDDRHDCGTAPIQYTDLGTEVRDHVIDATREMFRLHCAKHLEISSMYLLDGSTQINRNTVKLLSHGGDILELCHE

Query:  LRLPFLNWLVSSQ
        LRLPFLNWLVSSQ
Subjt:  LRLPFLNWLVSSQ

A0A1S3BDF8 Non-specific serine/threonine protein kinase

2.7e-55

97.35

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Query:  MKSSEDSSIYDRVVNAIFDEETLVMKDDRHDCGTAPIQYTDLGTEVRDHVIDATREMFRLHCAKHLEISSMYLLDGSTQINRNTVKLLSHGGDILELCHE
        MK SEDSSIYDRVVNAIFDEETLVMKDDRHDC TA IQYTDLGTEVRDHVIDATREMFRLHCAKHLEISSMYLLDGSTQINRNTVKLLSHGGDILELCHE
Subjt:  MKSSEDSSIYDRVVNAIFDEETLVMKDDRHDCGTAPIQYTDLGTEVRDHVIDATREMFRLHCAKHLEISSMYLLDGSTQINRNTVKLLSHGGDILELCHE

Query:  LRLPFLNWLVSSQ
        LRLPFLNWLVSSQ
Subjt:  LRLPFLNWLVSSQ

A0A1S3BE48 eIF-2-alpha kinase GCN2 isoform X4

2.7e-55

97.35

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Query:  MKSSEDSSIYDRVVNAIFDEETLVMKDDRHDCGTAPIQYTDLGTEVRDHVIDATREMFRLHCAKHLEISSMYLLDGSTQINRNTVKLLSHGGDILELCHE
        MK SEDSSIYDRVVNAIFDEETLVMKDDRHDC TA IQYTDLGTEVRDHVIDATREMFRLHCAKHLEISSMYLLDGSTQINRNTVKLLSHGGDILELCHE
Subjt:  MKSSEDSSIYDRVVNAIFDEETLVMKDDRHDCGTAPIQYTDLGTEVRDHVIDATREMFRLHCAKHLEISSMYLLDGSTQINRNTVKLLSHGGDILELCHE

Query:  LRLPFLNWLVSSQ
        LRLPFLNWLVSSQ
Subjt:  LRLPFLNWLVSSQ

A0A1S3BE99 Non-specific serine/threonine protein kinase

2.7e-55

97.35

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Query:  MKSSEDSSIYDRVVNAIFDEETLVMKDDRHDCGTAPIQYTDLGTEVRDHVIDATREMFRLHCAKHLEISSMYLLDGSTQINRNTVKLLSHGGDILELCHE
        MK SEDSSIYDRVVNAIFDEETLVMKDDRHDC TA IQYTDLGTEVRDHVIDATREMFRLHCAKHLEISSMYLLDGSTQINRNTVKLLSHGGDILELCHE
Subjt:  MKSSEDSSIYDRVVNAIFDEETLVMKDDRHDCGTAPIQYTDLGTEVRDHVIDATREMFRLHCAKHLEISSMYLLDGSTQINRNTVKLLSHGGDILELCHE

Query:  LRLPFLNWLVSSQ
        LRLPFLNWLVSSQ
Subjt:  LRLPFLNWLVSSQ

A0A1S4DWM3 Non-specific serine/threonine protein kinase

2.7e-55

97.35

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Query:  MKSSEDSSIYDRVVNAIFDEETLVMKDDRHDCGTAPIQYTDLGTEVRDHVIDATREMFRLHCAKHLEISSMYLLDGSTQINRNTVKLLSHGGDILELCHE
        MK SEDSSIYDRVVNAIFDEETLVMKDDRHDC TA IQYTDLGTEVRDHVIDATREMFRLHCAKHLEISSMYLLDGSTQINRNTVKLLSHGGDILELCHE
Subjt:  MKSSEDSSIYDRVVNAIFDEETLVMKDDRHDCGTAPIQYTDLGTEVRDHVIDATREMFRLHCAKHLEISSMYLLDGSTQINRNTVKLLSHGGDILELCHE

Query:  LRLPFLNWLVSSQ
        LRLPFLNWLVSSQ
Subjt:  LRLPFLNWLVSSQ

SwissProt top hits

e value

%identity

Alignment

Q9LX30 eIF-2-alpha kinase GCN2

1.3e-30

55.08

Show/hide

Query:  MKSSEDSSIYDRVVNAIFDEETLVMKD-----DRHDCGTAPIQYTDLGTEVRDHVIDATREMFRLHCAKHLEISSMYLLDGSTQINRNTVKLLSHGGDIL
        M++SEDSS+YDRVV+ IFDEE L MK       R     + IQYT++ TE+RD+V++ T+E+FR HCAKHLE+  M LL    Q +R TVKLL++GGD+L
Subjt:  MKSSEDSSIYDRVVNAIFDEETLVMKD-----DRHDCGTAPIQYTDLGTEVRDHVIDATREMFRLHCAKHLEISSMYLLDGSTQINRNTVKLLSHGGDIL

Query:  ELCHELRLPFLNWLVSSQ
        ELC+ELRLPF++W+  +Q
Subjt:  ELCHELRLPFLNWLVSSQ

Arabidopsis top hits

e value

%identity

Alignment

AT3G59410.1 protein kinase family protein

9.4e-32

55.08

Show/hide

Query:  MKSSEDSSIYDRVVNAIFDEETLVMKD-----DRHDCGTAPIQYTDLGTEVRDHVIDATREMFRLHCAKHLEISSMYLLDGSTQINRNTVKLLSHGGDIL
        M++SEDSS+YDRVV+ IFDEE L MK       R     + IQYT++ TE+RD+V++ T+E+FR HCAKHLE+  M LL    Q +R TVKLL++GGD+L
Subjt:  MKSSEDSSIYDRVVNAIFDEETLVMKD-----DRHDCGTAPIQYTDLGTEVRDHVIDATREMFRLHCAKHLEISSMYLLDGSTQINRNTVKLLSHGGDIL

Query:  ELCHELRLPFLNWLVSSQ
        ELC+ELRLPF++W+  +Q
Subjt:  ELCHELRLPFLNWLVSSQ

AT3G59410.2 protein kinase family protein

9.4e-32

55.08

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Query:  MKSSEDSSIYDRVVNAIFDEETLVMKD-----DRHDCGTAPIQYTDLGTEVRDHVIDATREMFRLHCAKHLEISSMYLLDGSTQINRNTVKLLSHGGDIL
        M++SEDSS+YDRVV+ IFDEE L MK       R     + IQYT++ TE+RD+V++ T+E+FR HCAKHLE+  M LL    Q +R TVKLL++GGD+L
Subjt:  MKSSEDSSIYDRVVNAIFDEETLVMKD-----DRHDCGTAPIQYTDLGTEVRDHVIDATREMFRLHCAKHLEISSMYLLDGSTQINRNTVKLLSHGGDIL

Query:  ELCHELRLPFLNWLVSSQ
        ELC+ELRLPF++W+  +Q
Subjt:  ELCHELRLPFLNWLVSSQ

Sequences

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CDS sequence

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ATGAAATCATCAGAAGACTCAAGTATATATGACAGAGTTGTTAATGCTATTTTCGACGAAGAGACATTAGTGATGAAAGATGACAGACATGATTGTGGTACTGCCCCTAT
CCAATACACAGATTTGGGCACTGAAGTTCGTGATCATGTTATTGATGCCACAAGGGAGATGTTCAGGCTGCATTGTGCAAAGCATTTGGAAATAAGTTCCATGTATTTGT
TGGATGGCTCTACGCAAATCAATAGGAACACGGTCAAACTTTTGAGCCATGGAGGAGATATACTTGAACTCTGCCATGAGCTGCGTTTACCTTTTCTTAATTGGCTTGTC
TCCAGTCAGGATGAAGAGAATTCTTCATGGTGTCAGGTCATTAGAAGCCTTCACGGTAAAAATTCTTATAATTGGCACACGGTGGGGAAGAATGGCAACAGTCTGAGAAG
CCTTTGGATTAGCATTTCTAGAAATTGGCTGAAAGTTGAAGTATTGGCTACTTTTAAACTTGGCAATGGCACCAGAATTGCTTTTTGGTTGGACCCTTGGAATGATTTGG
TCCCTTTGTGTAGTTGCTTTCCAAGGTTGTATAGGAACCAAAGGGTATTTCATGACAAACAACTTAGGTGGATGGAACGGTTCGAGGTGGCTCACTTGAATGCTCCATCT
TGGTGCACGTTATCCAAGCTTTTTGAAGACTTCTCCATTCAAGATCTAAGTTTAATTTGGCACACCTTTATTTTTCCAGATTAA

mRNA sequence

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Protein sequence

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MKSSEDSSIYDRVVNAIFDEETLVMKDDRHDCGTAPIQYTDLGTEVRDHVIDATREMFRLHCAKHLEISSMYLLDGSTQINRNTVKLLSHGGDILELCHELRLPFLNWLV
SSQDEENSSWCQVIRSLHGKNSYNWHTVGKNGNSLRSLWISISRNWLKVEVLATFKLGNGTRIAFWLDPWNDLVPLCSCFPRLYRNQRVFHDKQLRWMERFEVAHLNAPS
WCTLSKLFEDFSIQDLSLIWHTFIFPD

HG10003828 (gene) of Bottle gourd (Hangzhou Gourd) v1 genome