CuGenDBv2

Gene ID	HG10007870
Organism	Lagenaria siceraria cv. Hangzhou Gourd (Bottle gourd (Hangzhou Gourd) v1)
Description	multisubstrate pseudouridine synthase 7 isoform X1
Genome location	Chr10:16268330..16272317
RNA-Seq Expression	HG10007870
Synteny	HG10007870
Gene Ontology terms	GO:0001522 - pseudouridine synthesis (biological process) GO:0008033 - tRNA processing (biological process) GO:0003723 - RNA binding (molecular function) GO:0009982 - pseudouridine synthase activity (molecular function)
InterPro domains	IPR001656 - Pseudouridine synthase, TruD IPR020103 - Pseudouridine synthase, catalytic domain superfamily IPR042214 - Pseudouridine synthase, TruD, catalytic domain

Homology

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GenBank top hits

e value

%identity

Alignment

KAA0062573.1 pseudouridylate synthase 7-like protein isoform X1 [Cucumis melo var. makuwa]

1.9e-47

80.99

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Query:  QSALWGERL-VSLACWWIDKVVVGDLVYCKENHTETTAVQNFEEYENEDCGDANSYDSCHLEEMCKLDPPTERNKLVKAVTAEDILTGNFTINDVVLPLP
        QS LW     + +  + IDKVVVGDLVYCKENHTET AVQN EEYE+EDCGDANSYDSCHLEEMCKL  PTERNKLVKAVTAED+L+GNFTI+DVVLPLP
Subjt:  QSALWGERL-VSLACWWIDKVVVGDLVYCKENHTETTAVQNFEEYENEDCGDANSYDSCHLEEMCKLDPPTERNKLVKAVTAEDILTGNFTINDVVLPLP

Query:  GSRVIYPTNDIAEVYNDLATK
        GSRV+YP NDIAEVYNDLATK
Subjt:  GSRVIYPTNDIAEVYNDLATK

TYK28794.1 pseudouridylate synthase 7-like protein isoform X2 [Cucumis melo var. makuwa]

2.9e-48

90.65

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Query:  IDKVVVGDLVYCKENHTETTAVQNFEEYENEDCGDANSYDSCHLEEMCKLDPPTERNKLVKAVTAEDILTGNFTINDVVLPLPGSRVIYPTNDIAEVYND
        IDKVVVGDLVYCKENHTET AVQN EEYE+EDCGDANSYDSCHLEEMCKL  PTERNKLVKAVTAED+L+GNFTI+DVVLPLPGSRV+YP NDIAEVYND
Subjt:  IDKVVVGDLVYCKENHTETTAVQNFEEYENEDCGDANSYDSCHLEEMCKLDPPTERNKLVKAVTAEDILTGNFTINDVVLPLPGSRVIYPTNDIAEVYND

Query:  LATKVLY
        LATKVLY
Subjt:  LATKVLY

XP_038878530.1 pseudouridylate synthase 7 homolog isoform X1 [Benincasa hispida]

1.3e-51

85.95

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Query:  QSALWGERL-VSLACWWIDKVVVGDLVYCKENHTETTAVQNFEEYENEDCGDANSYDSCHLEEMCKLDPPTERNKLVKAVTAEDILTGNFTINDVVLPLP
        QS LW     + +  + IDKVVVGDLVYCKENHTET AVQNFEEYENEDCGDANSYDSCHLEEMCKLDPPTERNKLVKAVTAED+L+GNFTI+DVVLPLP
Subjt:  QSALWGERL-VSLACWWIDKVVVGDLVYCKENHTETTAVQNFEEYENEDCGDANSYDSCHLEEMCKLDPPTERNKLVKAVTAEDILTGNFTINDVVLPLP

Query:  GSRVIYPTNDIAEVYNDLATK
        GSRVIYPTNDIAEVYNDLATK
Subjt:  GSRVIYPTNDIAEVYNDLATK

XP_038878531.1 pseudouridylate synthase 7 homolog isoform X2 [Benincasa hispida]

1.3e-51

85.95

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Query:  QSALWGERL-VSLACWWIDKVVVGDLVYCKENHTETTAVQNFEEYENEDCGDANSYDSCHLEEMCKLDPPTERNKLVKAVTAEDILTGNFTINDVVLPLP
        QS LW     + +  + IDKVVVGDLVYCKENHTET AVQNFEEYENEDCGDANSYDSCHLEEMCKLDPPTERNKLVKAVTAED+L+GNFTI+DVVLPLP
Subjt:  QSALWGERL-VSLACWWIDKVVVGDLVYCKENHTETTAVQNFEEYENEDCGDANSYDSCHLEEMCKLDPPTERNKLVKAVTAEDILTGNFTINDVVLPLP

Query:  GSRVIYPTNDIAEVYNDLATK
        GSRVIYPTNDIAEVYNDLATK
Subjt:  GSRVIYPTNDIAEVYNDLATK

XP_038878534.1 multisubstrate pseudouridine synthase 7 isoform X4 [Benincasa hispida]

7.5e-52

83.87

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Query:  QSALWGERL-VSLACWWIDKVVVGDLVYCKENHTETTAVQNFEEYENEDCGDANSYDSCHLEEMCKLDPPTERNKLVKAVTAEDILTGNFTINDVVLPLP
        QS LW     + +  + IDKVVVGDLVYCKENHTET AVQNFEEYENEDCGDANSYDSCHLEEMCKLDPPTERNKLVKAVTAED+L+GNFTI+DVVLPLP
Subjt:  QSALWGERL-VSLACWWIDKVVVGDLVYCKENHTETTAVQNFEEYENEDCGDANSYDSCHLEEMCKLDPPTERNKLVKAVTAEDILTGNFTINDVVLPLP

Query:  GSRVIYPTNDIAEVYNDLATKVLY
        GSRVIYPTNDIAEVYNDLATK ++
Subjt:  GSRVIYPTNDIAEVYNDLATKVLY

TrEMBL top hits

e value

%identity

Alignment

A0A0A0LY46 TRUD domain-containing protein

3.2e-48

79.84

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Query:  QSALWGERL-VSLACWWIDKVVVGDLVYCKENHTETTAVQNFEEYENEDCGDANSYDSCHLEEMCKLDPPTERNKLVKAVTAEDILTGNFTINDVVLPLP
        QS LW     + +  + IDKVVVGDLVYCKENHTET AVQN EEYE+EDCGDANSYDSCHLEE+CKL  PTER+KLVKAVTA D+L+GNFTI+DVVLPLP
Subjt:  QSALWGERL-VSLACWWIDKVVVGDLVYCKENHTETTAVQNFEEYENEDCGDANSYDSCHLEEMCKLDPPTERNKLVKAVTAEDILTGNFTINDVVLPLP

Query:  GSRVIYPTNDIAEVYNDLATKVLY
        GSRV+YPTNDIAEVYNDLATKVLY
Subjt:  GSRVIYPTNDIAEVYNDLATKVLY

A0A1S3CHJ1 pseudouridylate synthase 7 homolog isoform X1

9.2e-48

80.99

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Query:  QSALWGERL-VSLACWWIDKVVVGDLVYCKENHTETTAVQNFEEYENEDCGDANSYDSCHLEEMCKLDPPTERNKLVKAVTAEDILTGNFTINDVVLPLP
        QS LW     + +  + IDKVVVGDLVYCKENHTET AVQN EEYE+EDCGDANSYDSCHLEEMCKL  PTERNKLVKAVTAED+L+GNFTI+DVVLPLP
Subjt:  QSALWGERL-VSLACWWIDKVVVGDLVYCKENHTETTAVQNFEEYENEDCGDANSYDSCHLEEMCKLDPPTERNKLVKAVTAEDILTGNFTINDVVLPLP

Query:  GSRVIYPTNDIAEVYNDLATK
        GSRV+YP NDIAEVYNDLATK
Subjt:  GSRVIYPTNDIAEVYNDLATK

A0A1S3CI40 pseudouridylate synthase 7 homolog isoform X2

9.2e-48

80.99

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Query:  QSALWGERL-VSLACWWIDKVVVGDLVYCKENHTETTAVQNFEEYENEDCGDANSYDSCHLEEMCKLDPPTERNKLVKAVTAEDILTGNFTINDVVLPLP
        QS LW     + +  + IDKVVVGDLVYCKENHTET AVQN EEYE+EDCGDANSYDSCHLEEMCKL  PTERNKLVKAVTAED+L+GNFTI+DVVLPLP
Subjt:  QSALWGERL-VSLACWWIDKVVVGDLVYCKENHTETTAVQNFEEYENEDCGDANSYDSCHLEEMCKLDPPTERNKLVKAVTAEDILTGNFTINDVVLPLP

Query:  GSRVIYPTNDIAEVYNDLATK
        GSRV+YP NDIAEVYNDLATK
Subjt:  GSRVIYPTNDIAEVYNDLATK

A0A5A7V3D9 Pseudouridylate synthase 7-like protein isoform X1

9.2e-48

80.99

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Query:  QSALWGERL-VSLACWWIDKVVVGDLVYCKENHTETTAVQNFEEYENEDCGDANSYDSCHLEEMCKLDPPTERNKLVKAVTAEDILTGNFTINDVVLPLP
        QS LW     + +  + IDKVVVGDLVYCKENHTET AVQN EEYE+EDCGDANSYDSCHLEEMCKL  PTERNKLVKAVTAED+L+GNFTI+DVVLPLP
Subjt:  QSALWGERL-VSLACWWIDKVVVGDLVYCKENHTETTAVQNFEEYENEDCGDANSYDSCHLEEMCKLDPPTERNKLVKAVTAEDILTGNFTINDVVLPLP

Query:  GSRVIYPTNDIAEVYNDLATK
        GSRV+YP NDIAEVYNDLATK
Subjt:  GSRVIYPTNDIAEVYNDLATK

A0A5D3DZ61 Pseudouridylate synthase 7-like protein isoform X2

1.4e-48

90.65

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Query:  IDKVVVGDLVYCKENHTETTAVQNFEEYENEDCGDANSYDSCHLEEMCKLDPPTERNKLVKAVTAEDILTGNFTINDVVLPLPGSRVIYPTNDIAEVYND
        IDKVVVGDLVYCKENHTET AVQN EEYE+EDCGDANSYDSCHLEEMCKL  PTERNKLVKAVTAED+L+GNFTI+DVVLPLPGSRV+YP NDIAEVYND
Subjt:  IDKVVVGDLVYCKENHTETTAVQNFEEYENEDCGDANSYDSCHLEEMCKLDPPTERNKLVKAVTAEDILTGNFTINDVVLPLPGSRVIYPTNDIAEVYND

Query:  LATKVLY
        LATKVLY
Subjt:  LATKVLY

SwissProt top hits

e value

%identity

Alignment

O74343 Multisubstrate pseudouridine synthase 7

5.4e-05

29.2

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Query:  FSRCQYYDRGVPP---QSALWGERLVSLACWWI----DKVVVGDLVYCKENHTETTAVQNFEEYENEDCGDANSYDSCHLEEMCKLDPPTERNKLVKAVT
        F R   + R + P   QS +W      +A W I    D+ VVGDLVY     TE+  +       + +  D        LE++     P       + + 
Subjt:  FSRCQYYDRGVPP---QSALWGERLVSLACWWI----DKVVVGDLVYCKENHTETTAVQNFEEYENEDCGDANSYDSCHLEEMCKLDPPTERNKLVKAVT

Query:  AEDILTGNFTINDVVLPLPGSRVIYPTNDIAEVYNDL
         +++   NF+I D+VLPLPG  VIYP N+  ++Y  +
Subjt:  AEDILTGNFTINDVVLPLPGSRVIYPTNDIAEVYNDL

Arabidopsis top hits

e value

%identity

Alignment

AT3G04820.1 Pseudouridine synthase family protein

1.3e-17

38.3

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Query:  RVVSGIPFSRCQYYDRGVPPQSALWGERL-VSLACWWIDKVVVGDLVYCKENHTETTAVQNFEEYENEDCGDANSYDSCHLEEMCKLDPPTERNKLVKAV
        + + GIP +    Y      QS LW     + +  +   +VV+GDLV  K +  +   V +     NE   +A   D   +++   +D P ER+ LVK V
Subjt:  RVVSGIPFSRCQYYDRGVPPQSALWGERL-VSLACWWIDKVVVGDLVYCKENHTETTAVQNFEEYENEDCGDANSYDSCHLEEMCKLDPPTERNKLVKAV

Query:  TAEDILTGNFTINDVVLPLPGSRVIYPTNDIAEVYNDLATK
        + ED+  G ++ +D+VLPLPGSRVIYP+NDIAE+Y+DLA K
Subjt:  TAEDILTGNFTINDVVLPLPGSRVIYPTNDIAEVYNDLATK

Sequences

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CDS sequence

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ATGTCTTCGGCTGCTAGACCTCATGCCGTTCACACCACCATGGCTAGACAAGGACAGACCAGAGTGGTTACCATTAAAAGGAAGACCTGGACCATATTCTTTGGCGCTGT
GACTTCGCGAGTGGTGTCTGGGATTCCTTTCTCCAGATGTCAGTACTATGATCGAGGAGTTCCTCCTCAATCCGCCTTATGGGGAGAAAGACTGGTTTCTTTGGCGTGCT
GGTGGATTGACAAAGTGGTTGTTGGAGACTTGGTATACTGTAAAGAAAACCATACTGAAACAACTGCAGTTCAAAATTTTGAAGAATATGAAAATGAGGACTGTGGCGAT
GCTAATTCATACGATTCTTGTCATTTAGAGGAAATGTGCAAGCTAGATCCTCCAACAGAAAGAAATAAGCTAGTGAAGGCTGTAACTGCAGAAGATATCCTCACTGGAAA
CTTTACTATTAATGACGTTGTTCTTCCGTTGCCTGGGTCAAGAGTAATCTATCCCACAAATGATATTGCTGAAGTGTATAATGATTTAGCAACTAAGGTCCTTTATTATT
CTTAG

mRNA sequence

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Protein sequence

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MSSAARPHAVHTTMARQGQTRVVTIKRKTWTIFFGAVTSRVVSGIPFSRCQYYDRGVPPQSALWGERLVSLACWWIDKVVVGDLVYCKENHTETTAVQNFEEYENEDCGD
ANSYDSCHLEEMCKLDPPTERNKLVKAVTAEDILTGNFTINDVVLPLPGSRVIYPTNDIAEVYNDLATKVLYYS

HG10007870 (gene) of Bottle gourd (Hangzhou Gourd) v1 genome