CuGenDBv2

Gene ID	HG10012433
Organism	Lagenaria siceraria cv. Hangzhou Gourd (Bottle gourd (Hangzhou Gourd) v1)
Description	DNA topoisomerase
Genome location	Chr01:21175552..21196839
RNA-Seq Expression	HG10012433
Synteny	HG10012433
Gene Ontology terms	GO:0006265 - DNA topological change (biological process) GO:0005634 - nucleus (cellular component) GO:0003677 - DNA binding (molecular function) GO:0003917 - DNA topoisomerase type I activity (molecular function)
InterPro domains	IPR000380 - DNA topoisomerase, type IA IPR003601 - DNA topoisomerase, type IA, domain 2 IPR003602 - DNA topoisomerase, type IA, DNA-binding domain IPR013497 - DNA topoisomerase, type IA, central IPR013824 - DNA topoisomerase, type IA, central region, subdomain 1 IPR013825 - DNA topoisomerase, type IA, central region, subdomain 2 IPR013826 - DNA topoisomerase, type IA, central region, subdomain 3 IPR023405 - DNA topoisomerase, type IA, core domain IPR023406 - DNA topoisomerase, type IA, active site

Homology

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GenBank top hits

e value

%identity

Alignment

KAA0067650.1 DNA topoisomerase 3-beta [Cucumis melo var. makuwa]

0.0e+00

92.77

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Query:  MVASTVLMVAEKPSIALSIASALSHGQMSTRKGSTDVHEFDGRFLGYHAHYKVTSVIGHVFSIDFPAGFQDWKTTDPLDLFQASVIKTESNPKFLLGPLV
        MVASTVLMVAEKPSIALSIASALSHGQMSTRKGST+VHEFDGRFLG+HA+YKVTSVIGH+FSIDF AGFQDWKTT+PLDLFQASVIKTESNPK  +   +
Subjt:  MVASTVLMVAEKPSIALSIASALSHGQMSTRKGSTDVHEFDGRFLGYHAHYKVTSVIGHVFSIDFPAGFQDWKTTDPLDLFQASVIKTESNPKFLLGPLV

Query:  --------CFVLLI----RFLLVLLAVIECTGFGGNEIRKKVYRARFSSVTEKDILKALDNLVQPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYG
                C VL +        +   VIECTGFGGN  RKKVYRARFSSVTEKDILKALDNLV+PNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYG
Subjt:  --------CFVLLI----RFLLVLLAVIECTGFGGNEIRKKVYRARFSSVTEKDILKALDNLVQPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYG

Query:  NLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYIMQNGYELNLDWERGKLFDCDVTAMFQKRVMEDGIAEVTEISEKQENKVRPSGLNTVNL
        NLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYIMQNGYELNLDWERGKLFDCDVTAMFQKRV+EDGIAEVTEISEKQENKVRPSGLNTVNL
Subjt:  NLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYIMQNGYELNLDWERGKLFDCDVTAMFQKRVMEDGIAEVTEISEKQENKVRPSGLNTVNL

Query:  LKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHSLVKNPEWGDYVRMFLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAW
        LKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLH+LVKNPEWGDYVRM LSDGYSKPRSGTDVGDHPPITPMC ATEDMLGRDAW
Subjt:  LKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHSLVKNPEWGDYVRMFLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAW

Query:  RLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVIVKGFTSIMPWLAVNEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELISLMEKHG
        RLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRV VKGFTSIMPWLAVNEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELISLMEKHG
Subjt:  RLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVIVKGFTSIMPWLAVNEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELISLMEKHG

Query:  IGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEQQITLVAKGQADHSSVVQNVLQQFKQKYSYFVEKIDHMDALF
        IGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIE QITLVAKGQADHSSVV++VLQQFKQKYSYFV+KID MDALF
Subjt:  IGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEQQITLVAKGQADHSSVVQNVLQQFKQKYSYFVEKIDHMDALF

Query:  EAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCSICEEVYYLPQKGAIKLYKELTCPLDNFELLIFSLPGPEGKSFPLCPYCYNSPPFEGIDTLYGA
        EAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYC ICEEVYYLPQKG IKLYKELTCPLDNFELLI SLPGPEGKSFPLCPYCYNSPPFEGIDTLYGA
Subjt:  EAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCSICEEVYYLPQKGAIKLYKELTCPLDNFELLIFSLPGPEGKSFPLCPYCYNSPPFEGIDTLYGA

Query:  AKTNPSSGALSKGMGMPCFLCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPQGAHRISTTNEKCADCDSTIIEVDFNKKTTP
        +KTNPSSG  SKGMGMPCFLCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPQGAHRISTT++KCADCDSTIIEVDFNKKTTP
Subjt:  AKTNPSSGALSKGMGMPCFLCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPQGAHRISTTNEKCADCDSTIIEVDFNKKTTP

Query:  LEDGATLFVGCILCDEFLHSLLEMKHGKSFFRGRGSRGRGRGRGRGRG-GR-GRGRNSGKPMDPKMSFRDF
        LEDGATLFVGCILCDEFLHSLLEMKHG SF R R SRGRGRGRGRGRG GR GRGRNSGKPMDPKMSFRDF
Subjt:  LEDGATLFVGCILCDEFLHSLLEMKHGKSFFRGRGSRGRGRGRGRGRG-GR-GRGRNSGKPMDPKMSFRDF

XP_004147675.1 DNA topoisomerase 3-beta isoform X1 [Cucumis sativus]

0.0e+00

92.41

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Query:  MVASTVLMVAEKPSIALSIASALSHGQMSTRKGSTDVHEFDGRFLGYHAHYKVTSVIGHVFSIDFPAGFQDWKTTDPLDLFQASVIKTESNPKFLLGPLV
        MVA TVLMVAEKPSIALSIASALSHGQMSTRKGST+VHEFDGRFLG+HA+YKVTSVIGHVFSIDF AGFQDWK+TDPLDLFQASVIKTESNPK  +   +
Subjt:  MVASTVLMVAEKPSIALSIASALSHGQMSTRKGSTDVHEFDGRFLGYHAHYKVTSVIGHVFSIDFPAGFQDWKTTDPLDLFQASVIKTESNPKFLLGPLV

Query:  --------CFVLLI----RFLLVLLAVIECTGFGGNEIRKKVYRARFSSVTEKDILKALDNLVQPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYG
                C VL +        +   VIECTGFGGN  RKKVYRARFSSVTEKDILKALDNLV+PNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYG
Subjt:  --------CFVLLI----RFLLVLLAVIECTGFGGNEIRKKVYRARFSSVTEKDILKALDNLVQPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYG

Query:  NLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYIMQNGYELNLDWERGKLFDCDVTAMFQKRVMEDGIAEVTEISEKQENKVRPSGLNTVNL
        NLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYI+Q GYELNLDWERGKLFDCDVTAMFQKRV+EDGIAEVTEISEKQENKVRPSGLNTVNL
Subjt:  NLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYIMQNGYELNLDWERGKLFDCDVTAMFQKRVMEDGIAEVTEISEKQENKVRPSGLNTVNL

Query:  LKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHSLVKNPEWGDYVRMFLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAW
        LKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLH+LVKNPEWGDYVRM LSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAW
Subjt:  LKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHSLVKNPEWGDYVRMFLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAW

Query:  RLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVIVKGFTSIMPWLAVNEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELISLMEKHG
        RLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRV VKGFTSIMPWLAVNEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELISLMEKHG
Subjt:  RLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVIVKGFTSIMPWLAVNEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELISLMEKHG

Query:  IGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEQQITLVAKGQADHSSVVQNVLQQFKQKYSYFVEKIDHMDALF
        IGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIE QITLVAKGQADHSSVVQ+VLQQF+QKYSYFV+KIDHMDALF
Subjt:  IGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEQQITLVAKGQADHSSVVQNVLQQFKQKYSYFVEKIDHMDALF

Query:  EAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCSICEEVYYLPQKGAIKLYKELTCPLDNFELLIFSLPGPEGKSFPLCPYCYNSPPFEGIDTLYGA
        EAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYC ICEEVYYLPQKG IKLYKELTCPLDNFELLI+SLPGPEGKSFPLCPYCYNSPPFEGI+TLYGA
Subjt:  EAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCSICEEVYYLPQKGAIKLYKELTCPLDNFELLIFSLPGPEGKSFPLCPYCYNSPPFEGIDTLYGA

Query:  AKTNPSSGALSKGMGMPCFLCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPQGAHRISTTNEKCADCDSTIIEVDFNKKTTP
        +K NPSSG  SKGMGMPCF+CPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLP+GAHRISTT +KCADCDSTIIEVDFNKKTTP
Subjt:  AKTNPSSGALSKGMGMPCFLCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPQGAHRISTTNEKCADCDSTIIEVDFNKKTTP

Query:  LEDGATLFVGCILCDEFLHSLLEMKHGKSFFRGRGSRGRGRGRGRGRGGRGRGRNSGKPMDPKMSFRDF
        LEDGATLFVGCILCDEFLHSLLEMKHGKSF R RGSRGRGRGRGRGRG  GRGR+SGKPMDPKMSFRDF
Subjt:  LEDGATLFVGCILCDEFLHSLLEMKHGKSFFRGRGSRGRGRGRGRGRGGRGRGRNSGKPMDPKMSFRDF

XP_008439059.1 PREDICTED: DNA topoisomerase 3-beta [Cucumis melo]

0.0e+00

92.75

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Query:  MVASTVLMVAEKPSIALSIASALSHGQMSTRKGSTDVHEFDGRFLGYHAHYKVTSVIGHVFSIDFPAGFQDWKTTDPLDLFQASVIKTESNPKFLLGPLV
        MVASTVLMVAEKPSIALSIASALSHGQMSTRKGST+VHEFDGRFLG+HA+YKVTSVIGH+FSIDF AGFQDWKTT+PLDLFQASVIKTESNPK  +   +
Subjt:  MVASTVLMVAEKPSIALSIASALSHGQMSTRKGSTDVHEFDGRFLGYHAHYKVTSVIGHVFSIDFPAGFQDWKTTDPLDLFQASVIKTESNPKFLLGPLV

Query:  --------CFVLLI----RFLLVLLAVIECTGFGGNEIRKKVYRARFSSVTEKDILKALDNLVQPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYG
                C VL +        +   VIECTGFGGN  RKKVYRARFSSVTEKDILKALDNLV+PNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYG
Subjt:  --------CFVLLI----RFLLVLLAVIECTGFGGNEIRKKVYRARFSSVTEKDILKALDNLVQPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYG

Query:  NLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYIMQNGYELNLDWERGKLFDCDVTAMFQKRVMEDGIAEVTEISEKQENKVRPSGLNTVNL
        NLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYIMQNGYELNLDWERGKLFDCDVTAMFQKRV+EDGIAEVTEISEKQENKVRPSGLNTVNL
Subjt:  NLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYIMQNGYELNLDWERGKLFDCDVTAMFQKRVMEDGIAEVTEISEKQENKVRPSGLNTVNL

Query:  LKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHSLVKNPEWGDYVRMFLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAW
        LKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLH+LVKNPEWGDYVRM LSDGYSKPRSGTDVGDHPPITPMC ATEDMLGRDAW
Subjt:  LKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHSLVKNPEWGDYVRMFLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAW

Query:  RLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVIVKGFTSIMPWLAVNEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELISLMEKHG
        RLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRV VKGFTSIMPWLAVNEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELISLMEKHG
Subjt:  RLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVIVKGFTSIMPWLAVNEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELISLMEKHG

Query:  IGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEQQITLVAKGQADHSSVVQNVLQQFKQKYSYFVEKIDHMDALF
        IGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIE QITLVAKGQADHSSVV++VLQQFKQKYSYFV+KID MDALF
Subjt:  IGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEQQITLVAKGQADHSSVVQNVLQQFKQKYSYFVEKIDHMDALF

Query:  EAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCSICEEVYYLPQKGAIKLYKELTCPLDNFELLIFSLPGPEGKSFPLCPYCYNSPPFEGIDTLYGA
        EAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYC ICEEVYYLPQKG IKLYKELTCPLDNFELLI SLPGPEGKSFPLCPYCYNSPPFEGIDTLYGA
Subjt:  EAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCSICEEVYYLPQKGAIKLYKELTCPLDNFELLIFSLPGPEGKSFPLCPYCYNSPPFEGIDTLYGA

Query:  AKTNPSSGALSKGMGMPCFLCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPQGAHRISTTNEKCADCDSTIIEVDFNKKTTP
        +KTNPSSG  SKGMGMPCFLCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPQGAHRISTT++KCADCDSTIIEVDFNKKTTP
Subjt:  AKTNPSSGALSKGMGMPCFLCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPQGAHRISTTNEKCADCDSTIIEVDFNKKTTP

Query:  LEDGATLFVGCILCDEFLHSLLEMKHGKSFFRGRGSRGRGRGRGRGRGGRGRGRNSGKPMDPKMSFRDF
        LEDGATLFVGCILCDEFLHSLLEMKHG SF R R SRGRGRGRGRGRG  GRGRNSGKPMDPKMSFRDF
Subjt:  LEDGATLFVGCILCDEFLHSLLEMKHGKSFFRGRGSRGRGRGRGRGRGGRGRGRNSGKPMDPKMSFRDF

XP_023528530.1 DNA topoisomerase 3-beta isoform X1 [Cucurbita pepo subsp. pepo]

0.0e+00

92.06

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Query:  MVASTVLMVAEKPSIALSIASALSHGQMSTRKGSTDVHEFDGRFLGYHAHYKVTSVIGHVFSIDFPAGFQDWKTTDPLDLFQASVIKTESNPKFLLGPLV
        MVAS+VLMVAEKPSIALSIASALSHGQMSTRKGST+VHEFDGRFLG+HAHYKVTSVIGHVFSIDFPA FQDWK TDPLDLFQASVIK ESNPK  +   +
Subjt:  MVASTVLMVAEKPSIALSIASALSHGQMSTRKGSTDVHEFDGRFLGYHAHYKVTSVIGHVFSIDFPAGFQDWKTTDPLDLFQASVIKTESNPKFLLGPLV

Query:  --------CFVLLI----RFLLVLLAVIECTGFGGNEIRKKVYRARFSSVTEKDILKALDNLVQPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYG
                C VL +        +   VIECTGFGGN+ RKKVYRARFSSVTEKDILKALDNLV+PNRNEALAVDARQEIDLKVGV+FTRFQTTFFQGKYG
Subjt:  --------CFVLLI----RFLLVLLAVIECTGFGGNEIRKKVYRARFSSVTEKDILKALDNLVQPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYG

Query:  NLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYIMQNGYELNLDWERGKLFDCDVTAMFQKRVMEDGIAEVTEISEKQENKVRPSGLNTVNL
        NLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYIMQNGYELNLDWERG+LFDCDV  MFQKRVMEDGIAEVT+ISEKQE+KVRPSGLNTVNL
Subjt:  NLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYIMQNGYELNLDWERGKLFDCDVTAMFQKRVMEDGIAEVTEISEKQENKVRPSGLNTVNL

Query:  LKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHSLVKNPEWGDYVRMFLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAW
        LKVASSALG+GPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHSLVKNPEWGDYVRM LSDGYSKPRSGTDVGDHPPITPM LATEDM+GRDAW
Subjt:  LKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHSLVKNPEWGDYVRMFLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAW

Query:  RLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVIVKGFTSIMPWLAVNEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELISLMEKHG
        RLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGS V+VKGFTSIMPWLAVNEKKLPQFLKG+KIEVA+VDLYQGNT+PPDYLSESELISLMEKHG
Subjt:  RLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVIVKGFTSIMPWLAVNEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELISLMEKHG

Query:  IGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEQQITLVAKGQADHSSVVQNVLQQFKQKYSYFVEKIDHMDALF
        IGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEQQIT VAKGQADH SVVQNVLQQFKQKYSYFV+KIDHMDALF
Subjt:  IGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEQQITLVAKGQADHSSVVQNVLQQFKQKYSYFVEKIDHMDALF

Query:  EAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCSICEEVYYLPQKGAIKLYKELTCPLDNFELLIFSLPGPEGKSFPLCPYCYNSPPFEGIDTLYGA
        EAQFSPLA+SGRALSKCGKCLRYMKFISSQPQRLYC  CEEVYYLPQ+GAIKLYKELTCPLDNFELLIFSLPGPEGKSFPLCPYCYNSPPFEGIDTLYGA
Subjt:  EAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCSICEEVYYLPQKGAIKLYKELTCPLDNFELLIFSLPGPEGKSFPLCPYCYNSPPFEGIDTLYGA

Query:  AKTNPSSGALSKGMGMPCFLCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPQGAHRISTTNEKCADCDSTIIEVDFNKKTTP
        AKTNPSSGA SKGMGMPCFLCPHPTCRHSLITQGVCACPECSGTLVLDPV APNWKLNCNKCNCLVFLPQGAHRI+TTNEKCA+CDSTIIEVDFNKKTTP
Subjt:  AKTNPSSGALSKGMGMPCFLCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPQGAHRISTTNEKCADCDSTIIEVDFNKKTTP

Query:  LEDGATLFVGCILCDEFLHSLLEMKHGKSFFRGRGSRGRGRGRGRGRGGRGRGRNSGKPMDPKMSFRDF
        LE GATLFVGCILCDEFLHSLLEMKHGKSFFRGRGSRGRGRGRGRGR GRGRGR+SGK MDPKMSFRDF
Subjt:  LEDGATLFVGCILCDEFLHSLLEMKHGKSFFRGRGSRGRGRGRGRGRGGRGRGRNSGKPMDPKMSFRDF

XP_038891105.1 DNA topoisomerase 3-beta isoform X1 [Benincasa hispida]

0.0e+00

93.79

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Query:  MVASTVLMVAEKPSIALSIASALSHGQMSTRKGSTDVHEFDGRFLGYHAHYKVTSVIGHVFSIDFPAGFQDWKTTDPLDLFQASVIKTESNPKFLLGPLV
        MVASTVLMVAEKPSIALSIASALSHGQMSTRKGSTDVHEFDGRFLG+HAHYKVTSVIGHVFSIDFPAGFQDWK+TDPLDLFQASVIKTESNPK  +   +
Subjt:  MVASTVLMVAEKPSIALSIASALSHGQMSTRKGSTDVHEFDGRFLGYHAHYKVTSVIGHVFSIDFPAGFQDWKTTDPLDLFQASVIKTESNPKFLLGPLV

Query:  --------CFVLLI----RFLLVLLAVIECTGFGGNEIRKKVYRARFSSVTEKDILKALDNLVQPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYG
                C VL +        +   VIECTGFGGNEIRKKVYRARFSSVTEKDILKALDNLVQPN+NEALAVDARQEIDLKVGVAFTRFQTTFFQGKYG
Subjt:  --------CFVLLI----RFLLVLLAVIECTGFGGNEIRKKVYRARFSSVTEKDILKALDNLVQPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYG

Query:  NLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYIMQNGYELNLDWERGKLFDCDVTAMFQKRVMEDGIAEVTEISEKQENKVRPSGLNTVNL
        NLDSRLISYGPCQTPTLGFCVQRHLQITTF PEKFWSVCPYIMQNGYELNLDWERGKLFDCDVTAMFQKRV+EDGIAEVTEISEKQENKVRPSGLNTVNL
Subjt:  NLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYIMQNGYELNLDWERGKLFDCDVTAMFQKRVMEDGIAEVTEISEKQENKVRPSGLNTVNL

Query:  LKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHSLVKNPEWGDYVRMFLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAW
        LKVASSALGFGPQ+AMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLH+L+KN EWGDYVRM LSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAW
Subjt:  LKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHSLVKNPEWGDYVRMFLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAW

Query:  RLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVIVKGFTSIMPWLAVNEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELISLMEKHG
        RLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGE+FNCTGSRVIVKGFTSIMPWLAVNEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELISLMEKHG
Subjt:  RLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVIVKGFTSIMPWLAVNEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELISLMEKHG

Query:  IGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEQQITLVAKGQADHSSVVQNVLQQFKQKYSYFVEKIDHMDALF
        IGTDASIPVHINNIGERNYVQVQAGRRL PTNLGITL+RGYQCIDPDLCLPDIRSFIEQQITLVAKGQADHSSVVQNVLQQFKQKY YFV+KIDHMDALF
Subjt:  IGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEQQITLVAKGQADHSSVVQNVLQQFKQKYSYFVEKIDHMDALF

Query:  EAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCSICEEVYYLPQKGAIKLYKELTCPLDNFELLIFSLPGPEGKSFPLCPYCYNSPPFEGIDTLYGA
        EAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYC ICEEVYYLPQKGAIKLYKELTCPLDNFELLIFSLPGPEGKSFPLCPYCYNSPPFEGIDTLYGA
Subjt:  EAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCSICEEVYYLPQKGAIKLYKELTCPLDNFELLIFSLPGPEGKSFPLCPYCYNSPPFEGIDTLYGA

Query:  AKTNPSSGALSKGMGMPCFLCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPQGAHRISTTNEKCADCDSTIIEVDFNKKTTP
        AKTNPSSGA SKGMGMPCFLC HPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPQGAHRIST NEKCADCDSTIIEVDFNKKTTP
Subjt:  AKTNPSSGALSKGMGMPCFLCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPQGAHRISTTNEKCADCDSTIIEVDFNKKTTP

Query:  LEDGATLFVGCILCDEFLHSLLEMKHGKSFFRGRGSRGRGRGRGRGRGGRGRGRNSGKPMDPKMSFRDF
        LE GATLFVGCILCDEFLHSLLEMKHGKS FRGRGS  RGRGRGRGRGGRGRGRNSG+PMDPKMSFRDF
Subjt:  LEDGATLFVGCILCDEFLHSLLEMKHGKSFFRGRGSRGRGRGRGRGRGGRGRGRNSGKPMDPKMSFRDF

TrEMBL top hits

e value

%identity

Alignment

A0A0A0L9C7 DNA topoisomerase

0.0e+00

92.41

Show/hide

Query:  MVASTVLMVAEKPSIALSIASALSHGQMSTRKGSTDVHEFDGRFLGYHAHYKVTSVIGHVFSIDFPAGFQDWKTTDPLDLFQASVIKTESNPKFLLGPLV
        MVA TVLMVAEKPSIALSIASALSHGQMSTRKGST+VHEFDGRFLG+HA+YKVTSVIGHVFSIDF AGFQDWK+TDPLDLFQASVIKTESNPK  +   +
Subjt:  MVASTVLMVAEKPSIALSIASALSHGQMSTRKGSTDVHEFDGRFLGYHAHYKVTSVIGHVFSIDFPAGFQDWKTTDPLDLFQASVIKTESNPKFLLGPLV

Query:  --------CFVLLI----RFLLVLLAVIECTGFGGNEIRKKVYRARFSSVTEKDILKALDNLVQPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYG
                C VL +        +   VIECTGFGGN  RKKVYRARFSSVTEKDILKALDNLV+PNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYG
Subjt:  --------CFVLLI----RFLLVLLAVIECTGFGGNEIRKKVYRARFSSVTEKDILKALDNLVQPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYG

Query:  NLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYIMQNGYELNLDWERGKLFDCDVTAMFQKRVMEDGIAEVTEISEKQENKVRPSGLNTVNL
        NLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYI+Q GYELNLDWERGKLFDCDVTAMFQKRV+EDGIAEVTEISEKQENKVRPSGLNTVNL
Subjt:  NLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYIMQNGYELNLDWERGKLFDCDVTAMFQKRVMEDGIAEVTEISEKQENKVRPSGLNTVNL

Query:  LKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHSLVKNPEWGDYVRMFLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAW
        LKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLH+LVKNPEWGDYVRM LSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAW
Subjt:  LKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHSLVKNPEWGDYVRMFLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAW

Query:  RLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVIVKGFTSIMPWLAVNEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELISLMEKHG
        RLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRV VKGFTSIMPWLAVNEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELISLMEKHG
Subjt:  RLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVIVKGFTSIMPWLAVNEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELISLMEKHG

Query:  IGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEQQITLVAKGQADHSSVVQNVLQQFKQKYSYFVEKIDHMDALF
        IGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIE QITLVAKGQADHSSVVQ+VLQQF+QKYSYFV+KIDHMDALF
Subjt:  IGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEQQITLVAKGQADHSSVVQNVLQQFKQKYSYFVEKIDHMDALF

Query:  EAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCSICEEVYYLPQKGAIKLYKELTCPLDNFELLIFSLPGPEGKSFPLCPYCYNSPPFEGIDTLYGA
        EAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYC ICEEVYYLPQKG IKLYKELTCPLDNFELLI+SLPGPEGKSFPLCPYCYNSPPFEGI+TLYGA
Subjt:  EAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCSICEEVYYLPQKGAIKLYKELTCPLDNFELLIFSLPGPEGKSFPLCPYCYNSPPFEGIDTLYGA

Query:  AKTNPSSGALSKGMGMPCFLCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPQGAHRISTTNEKCADCDSTIIEVDFNKKTTP
        +K NPSSG  SKGMGMPCF+CPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLP+GAHRISTT +KCADCDSTIIEVDFNKKTTP
Subjt:  AKTNPSSGALSKGMGMPCFLCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPQGAHRISTTNEKCADCDSTIIEVDFNKKTTP

Query:  LEDGATLFVGCILCDEFLHSLLEMKHGKSFFRGRGSRGRGRGRGRGRGGRGRGRNSGKPMDPKMSFRDF
        LEDGATLFVGCILCDEFLHSLLEMKHGKSF R RGSRGRGRGRGRGRG  GRGR+SGKPMDPKMSFRDF
Subjt:  LEDGATLFVGCILCDEFLHSLLEMKHGKSFFRGRGSRGRGRGRGRGRGGRGRGRNSGKPMDPKMSFRDF

A0A1S3AYH7 DNA topoisomerase

0.0e+00

92.75

Show/hide

Query:  MVASTVLMVAEKPSIALSIASALSHGQMSTRKGSTDVHEFDGRFLGYHAHYKVTSVIGHVFSIDFPAGFQDWKTTDPLDLFQASVIKTESNPKFLLGPLV
        MVASTVLMVAEKPSIALSIASALSHGQMSTRKGST+VHEFDGRFLG+HA+YKVTSVIGH+FSIDF AGFQDWKTT+PLDLFQASVIKTESNPK  +   +
Subjt:  MVASTVLMVAEKPSIALSIASALSHGQMSTRKGSTDVHEFDGRFLGYHAHYKVTSVIGHVFSIDFPAGFQDWKTTDPLDLFQASVIKTESNPKFLLGPLV

Query:  --------CFVLLI----RFLLVLLAVIECTGFGGNEIRKKVYRARFSSVTEKDILKALDNLVQPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYG
                C VL +        +   VIECTGFGGN  RKKVYRARFSSVTEKDILKALDNLV+PNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYG
Subjt:  --------CFVLLI----RFLLVLLAVIECTGFGGNEIRKKVYRARFSSVTEKDILKALDNLVQPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYG

Query:  NLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYIMQNGYELNLDWERGKLFDCDVTAMFQKRVMEDGIAEVTEISEKQENKVRPSGLNTVNL
        NLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYIMQNGYELNLDWERGKLFDCDVTAMFQKRV+EDGIAEVTEISEKQENKVRPSGLNTVNL
Subjt:  NLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYIMQNGYELNLDWERGKLFDCDVTAMFQKRVMEDGIAEVTEISEKQENKVRPSGLNTVNL

Query:  LKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHSLVKNPEWGDYVRMFLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAW
        LKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLH+LVKNPEWGDYVRM LSDGYSKPRSGTDVGDHPPITPMC ATEDMLGRDAW
Subjt:  LKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHSLVKNPEWGDYVRMFLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAW

Query:  RLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVIVKGFTSIMPWLAVNEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELISLMEKHG
        RLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRV VKGFTSIMPWLAVNEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELISLMEKHG
Subjt:  RLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVIVKGFTSIMPWLAVNEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELISLMEKHG

Query:  IGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEQQITLVAKGQADHSSVVQNVLQQFKQKYSYFVEKIDHMDALF
        IGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIE QITLVAKGQADHSSVV++VLQQFKQKYSYFV+KID MDALF
Subjt:  IGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEQQITLVAKGQADHSSVVQNVLQQFKQKYSYFVEKIDHMDALF

Query:  EAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCSICEEVYYLPQKGAIKLYKELTCPLDNFELLIFSLPGPEGKSFPLCPYCYNSPPFEGIDTLYGA
        EAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYC ICEEVYYLPQKG IKLYKELTCPLDNFELLI SLPGPEGKSFPLCPYCYNSPPFEGIDTLYGA
Subjt:  EAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCSICEEVYYLPQKGAIKLYKELTCPLDNFELLIFSLPGPEGKSFPLCPYCYNSPPFEGIDTLYGA

Query:  AKTNPSSGALSKGMGMPCFLCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPQGAHRISTTNEKCADCDSTIIEVDFNKKTTP
        +KTNPSSG  SKGMGMPCFLCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPQGAHRISTT++KCADCDSTIIEVDFNKKTTP
Subjt:  AKTNPSSGALSKGMGMPCFLCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPQGAHRISTTNEKCADCDSTIIEVDFNKKTTP

Query:  LEDGATLFVGCILCDEFLHSLLEMKHGKSFFRGRGSRGRGRGRGRGRGGRGRGRNSGKPMDPKMSFRDF
        LEDGATLFVGCILCDEFLHSLLEMKHG SF R R SRGRGRGRGRGRG  GRGRNSGKPMDPKMSFRDF
Subjt:  LEDGATLFVGCILCDEFLHSLLEMKHGKSFFRGRGSRGRGRGRGRGRGGRGRGRNSGKPMDPKMSFRDF

A0A5A7VKD3 DNA topoisomerase

0.0e+00

92.77

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Query:  MVASTVLMVAEKPSIALSIASALSHGQMSTRKGSTDVHEFDGRFLGYHAHYKVTSVIGHVFSIDFPAGFQDWKTTDPLDLFQASVIKTESNPKFLLGPLV
        MVASTVLMVAEKPSIALSIASALSHGQMSTRKGST+VHEFDGRFLG+HA+YKVTSVIGH+FSIDF AGFQDWKTT+PLDLFQASVIKTESNPK  +   +
Subjt:  MVASTVLMVAEKPSIALSIASALSHGQMSTRKGSTDVHEFDGRFLGYHAHYKVTSVIGHVFSIDFPAGFQDWKTTDPLDLFQASVIKTESNPKFLLGPLV

Query:  --------CFVLLI----RFLLVLLAVIECTGFGGNEIRKKVYRARFSSVTEKDILKALDNLVQPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYG
                C VL +        +   VIECTGFGGN  RKKVYRARFSSVTEKDILKALDNLV+PNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYG
Subjt:  --------CFVLLI----RFLLVLLAVIECTGFGGNEIRKKVYRARFSSVTEKDILKALDNLVQPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYG

Query:  NLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYIMQNGYELNLDWERGKLFDCDVTAMFQKRVMEDGIAEVTEISEKQENKVRPSGLNTVNL
        NLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYIMQNGYELNLDWERGKLFDCDVTAMFQKRV+EDGIAEVTEISEKQENKVRPSGLNTVNL
Subjt:  NLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYIMQNGYELNLDWERGKLFDCDVTAMFQKRVMEDGIAEVTEISEKQENKVRPSGLNTVNL

Query:  LKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHSLVKNPEWGDYVRMFLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAW
        LKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLH+LVKNPEWGDYVRM LSDGYSKPRSGTDVGDHPPITPMC ATEDMLGRDAW
Subjt:  LKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHSLVKNPEWGDYVRMFLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAW

Query:  RLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVIVKGFTSIMPWLAVNEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELISLMEKHG
        RLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRV VKGFTSIMPWLAVNEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELISLMEKHG
Subjt:  RLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVIVKGFTSIMPWLAVNEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELISLMEKHG

Query:  IGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEQQITLVAKGQADHSSVVQNVLQQFKQKYSYFVEKIDHMDALF
        IGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIE QITLVAKGQADHSSVV++VLQQFKQKYSYFV+KID MDALF
Subjt:  IGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEQQITLVAKGQADHSSVVQNVLQQFKQKYSYFVEKIDHMDALF

Query:  EAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCSICEEVYYLPQKGAIKLYKELTCPLDNFELLIFSLPGPEGKSFPLCPYCYNSPPFEGIDTLYGA
        EAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYC ICEEVYYLPQKG IKLYKELTCPLDNFELLI SLPGPEGKSFPLCPYCYNSPPFEGIDTLYGA
Subjt:  EAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCSICEEVYYLPQKGAIKLYKELTCPLDNFELLIFSLPGPEGKSFPLCPYCYNSPPFEGIDTLYGA

Query:  AKTNPSSGALSKGMGMPCFLCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPQGAHRISTTNEKCADCDSTIIEVDFNKKTTP
        +KTNPSSG  SKGMGMPCFLCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPQGAHRISTT++KCADCDSTIIEVDFNKKTTP
Subjt:  AKTNPSSGALSKGMGMPCFLCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPQGAHRISTTNEKCADCDSTIIEVDFNKKTTP

Query:  LEDGATLFVGCILCDEFLHSLLEMKHGKSFFRGRGSRGRGRGRGRGRG-GR-GRGRNSGKPMDPKMSFRDF
        LEDGATLFVGCILCDEFLHSLLEMKHG SF R R SRGRGRGRGRGRG GR GRGRNSGKPMDPKMSFRDF
Subjt:  LEDGATLFVGCILCDEFLHSLLEMKHGKSFFRGRGSRGRGRGRGRGRG-GR-GRGRNSGKPMDPKMSFRDF

A0A6J1GWS0 DNA topoisomerase

0.0e+00

91.83

Show/hide

Query:  MVASTVLMVAEKPSIALSIASALSHGQMSTRKGSTDVHEFDGRFLGYHAHYKVTSVIGHVFSIDFPAGFQDWKTTDPLDLFQASVIKTESNPKFLLGPLV
        MVAS+VLMVAEKPSIALSIASALSHGQMSTRKGST+VHEFDGRFLG+HAHYKVTSVIGHVFSIDFPA FQDWK TDPLDLFQASVIKTESNPK  +   +
Subjt:  MVASTVLMVAEKPSIALSIASALSHGQMSTRKGSTDVHEFDGRFLGYHAHYKVTSVIGHVFSIDFPAGFQDWKTTDPLDLFQASVIKTESNPKFLLGPLV

Query:  --------CFVLLI----RFLLVLLAVIECTGFGGNEIRKKVYRARFSSVTEKDILKALDNLVQPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYG
                C VL +        +   VIECTGFGGNE RKKVYRARFSSVTEKDILKALDNLV+PNRNEALAVDARQEIDLKVGV+FTRFQTTFFQGKYG
Subjt:  --------CFVLLI----RFLLVLLAVIECTGFGGNEIRKKVYRARFSSVTEKDILKALDNLVQPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYG

Query:  NLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYIMQNGYELNLDWERGKLFDCDVTAMFQKRVMEDGIAEVTEISEKQENKVRPSGLNTVNL
        NLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYIMQNGYELNLDWERG+LFDCDV  MFQKRVMEDGIAEVT+ISEKQE+KVRPSGLNTVNL
Subjt:  NLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYIMQNGYELNLDWERGKLFDCDVTAMFQKRVMEDGIAEVTEISEKQENKVRPSGLNTVNL

Query:  LKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHSLVKNPEWGDYVRMFLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAW
        LKVASSALG+GPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHSLVKNPEWGDYVR+ LSDGYSKPRSGTDVGDHPPITPM LATEDM+GRDAW
Subjt:  LKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHSLVKNPEWGDYVRMFLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAW

Query:  RLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVIVKGFTSIMPWLAVNEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELISLMEKHG
        RLYQYVCQHFIGSLSSDCKY+RTKIQFSIAGEIFNCTGS V+VKGFTSIMPWLAVNEKKLPQFLKG+KIEVA+VDLYQGNT+PPDYLSESELISLMEKHG
Subjt:  RLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVIVKGFTSIMPWLAVNEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELISLMEKHG

Query:  IGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEQQITLVAKGQADHSSVVQNVLQQFKQKYSYFVEKIDHMDALF
        IGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEQQIT VAKGQADH SVVQNVLQQFKQKYSYFV+KIDHMDALF
Subjt:  IGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEQQITLVAKGQADHSSVVQNVLQQFKQKYSYFVEKIDHMDALF

Query:  EAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCSICEEVYYLPQKGAIKLYKELTCPLDNFELLIFSLPGPEGKSFPLCPYCYNSPPFEGIDTLYGA
        EAQFSPLA+SGRALSKCGKCLRYMKFISSQPQRLYC  CEEVYYLPQ+GAIKLYKELTCPLDNFELLIFSLPGPEGKSFPLCPYCYNSPPFEGIDTLYGA
Subjt:  EAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCSICEEVYYLPQKGAIKLYKELTCPLDNFELLIFSLPGPEGKSFPLCPYCYNSPPFEGIDTLYGA

Query:  AKTNPSSGALSKGMGMPCFLCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPQGAHRISTTNEKCADCDSTIIEVDFNKKTTP
        AKTNPSSGA SKGMGMPCFLCPHPTCRHSLITQGVCACPECSGTLVLDPV APNWKLNCNKCNCLVFLPQGAHRI+TTNEKCA+CDSTIIEVDFNKKTTP
Subjt:  AKTNPSSGALSKGMGMPCFLCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPQGAHRISTTNEKCADCDSTIIEVDFNKKTTP

Query:  LEDGATLFVGCILCDEFLHSLLEMKHGKSFFRGRGSRGRGRGRGRGRGGRGRGRNSGKPMDPKMSFRDF
        LE GATLFVGCILCDEFLHSLLEMKHGKSFFRGRGSRGRGRGRGR   GRGRGR+SGK MDPKMSFRDF
Subjt:  LEDGATLFVGCILCDEFLHSLLEMKHGKSFFRGRGSRGRGRGRGRGRGGRGRGRNSGKPMDPKMSFRDF

A0A6J1IRJ0 DNA topoisomerase

0.0e+00

91.94

Show/hide

Query:  MVASTVLMVAEKPSIALSIASALSHGQMSTRKGSTDVHEFDGRFLGYHAHYKVTSVIGHVFSIDFPAGFQDWKTTDPLDLFQASVIKTESNPKFLLGPLV
        MVAS+VLMVAEKPSIALSIASALSHGQMSTRKGST+VHEFDGRFLG+HAHYKVTSVIGHVFSIDFPA FQDWK TDPLDLFQASVIKTESNPK  +   +
Subjt:  MVASTVLMVAEKPSIALSIASALSHGQMSTRKGSTDVHEFDGRFLGYHAHYKVTSVIGHVFSIDFPAGFQDWKTTDPLDLFQASVIKTESNPKFLLGPLV

Query:  --------CFVLLI----RFLLVLLAVIECTGFGGNEIRKKVYRARFSSVTEKDILKALDNLVQPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYG
                C VL +        +   VIECTGFGGNE RKKVYRARFSSVTEKDILKALDNLV+PNRNEALAVDARQEIDLKVGV+FTRFQTTFFQGKYG
Subjt:  --------CFVLLI----RFLLVLLAVIECTGFGGNEIRKKVYRARFSSVTEKDILKALDNLVQPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYG

Query:  NLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYIMQNGYELNLDWERGKLFDCDVTAMFQKRVMEDGIAEVTEISEKQENKVRPSGLNTVNL
        NLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYIMQNGYELNLDWERG+LFDCDV  MFQKRVMEDGIAEVT+ISEKQE+KVRPSGLNTVNL
Subjt:  NLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYIMQNGYELNLDWERGKLFDCDVTAMFQKRVMEDGIAEVTEISEKQENKVRPSGLNTVNL

Query:  LKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHSLVKNPEWGDYVRMFLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAW
        LKVASSALG+GPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHSLVKNPEWGDYVRM LSDGYSKPRSGTDVGDHPPITPM LATEDM+GRDAW
Subjt:  LKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHSLVKNPEWGDYVRMFLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAW

Query:  RLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVIVKGFTSIMPWLAVNEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELISLMEKHG
        RLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGS V+VKGFTSIMPWLAVNEKKLPQFLKG+KIEVA+VDLYQGNT+PPDYLSESELISLMEKHG
Subjt:  RLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVIVKGFTSIMPWLAVNEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELISLMEKHG

Query:  IGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEQQITLVAKGQADHSSVVQNVLQQFKQKYSYFVEKIDHMDALF
        IGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEQQIT VAKGQADH SVVQNVLQQFKQKYSYFV+KIDHMDALF
Subjt:  IGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEQQITLVAKGQADHSSVVQNVLQQFKQKYSYFVEKIDHMDALF

Query:  EAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCSICEEVYYLPQKGAIKLYKELTCPLDNFELLIFSLPGPEGKSFPLCPYCYNSPPFEGIDTLYGA
        EAQFSPLA+SGRALSKCGKCLRYMKFISSQPQRLYC  CEEVYYLPQ+GAIKLYKELTCPLDNFELLIFSLPGPEGKSFPLCPYCYNSPPFEGID LYGA
Subjt:  EAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCSICEEVYYLPQKGAIKLYKELTCPLDNFELLIFSLPGPEGKSFPLCPYCYNSPPFEGIDTLYGA

Query:  AKTNPSSGALSKGMGMPCFLCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPQGAHRISTTNEKCADCDSTIIEVDFNKKTTP
        AKTNPSSGA SKGMGMPCFLCPHPTCRHSLITQGVCACPECSGTLVLDPV APNWKLNCNKCNCLVFLPQGAHRI+TTNEKCA+CDSTIIEVDFNKKTTP
Subjt:  AKTNPSSGALSKGMGMPCFLCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPQGAHRISTTNEKCADCDSTIIEVDFNKKTTP

Query:  LEDGATLFVGCILCDEFLHSLLEMKHGKSFFRGRGSRGRGRGRGRGRGGRGRGRNSGKPMDPKMSFRDF
        LE GATLFVGCILCDEFLHSLLEMKHGKSFFRGRGSRGRGRGRGR   GRGRGR+SGK MDPKMSFRDF
Subjt:  LEDGATLFVGCILCDEFLHSLLEMKHGKSFFRGRGSRGRGRGRGRGRGGRGRGRNSGKPMDPKMSFRDF

SwissProt top hits

e value

%identity

Alignment

F4ISQ7 DNA topoisomerase 3-beta

0.0e+00

73.5

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Query:  VLMVAEKPSIALSIASALSHGQMSTRKGSTDVHEFDGRFLGYHAHYKVTSVIGHVFSIDFPAGFQDWKTTDPLDLFQASVIKTESNPK-----FLLGPLV
        VLMVAEKPSIALSIAS LSHGQMSTR+GST+VHEFDG F G+ AHY+VTSVIGHVFS+DFP  +Q+W T DP DLF A +IK ESNPK      L     
Subjt:  VLMVAEKPSIALSIASALSHGQMSTRKGSTDVHEFDGRFLGYHAHYKVTSVIGHVFSIDFPAGFQDWKTTDPLDLFQASVIKTESNPK-----FLLGPLV

Query:  CFVLLIRFL-------LVLLAVIECTGFGGNEIRKKVYRARFSSVTEKDILKALDNLVQPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYGNLDSR
            ++ +L        +   VIE TGF   + ++KVYRARFSSVTEKDI KA+DNLV+PNR+EALAVDARQEIDLKVGVAF+RFQT++FQGKY NLD R
Subjt:  CFVLLIRFL-------LVLLAVIECTGFGGNEIRKKVYRARFSSVTEKDILKALDNLVQPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYGNLDSR

Query:  LISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYIMQNGYELNLDWERGKLFDCDVTAMFQKRVMEDGIAEVTEISEKQENKVRPSGLNTVNLLKVAS
        +ISYGPCQTPTLGFCVQR++ I TFKPEKFW++ PYI ++GYEL L+WER +LFD +   +FQK V+E   A+V ++SEKQE K RP+GLNTVNLLKVAS
Subjt:  LISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYIMQNGYELNLDWERGKLFDCDVTAMFQKRVMEDGIAEVTEISEKQENKVRPSGLNTVNLLKVAS

Query:  SALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHSLVKNPEWGDYVRMFLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAWRLYQY
        SALGFGPQ AM LAERLYTQGFISYPRTESTAYPSSFDF  TL + V NP WG YV+  LSDG+  P+SGTD GDHPPITPM  ATE M+G DAWRLYQY
Subjt:  SALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHSLVKNPEWGDYVRMFLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAWRLYQY

Query:  VCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVIVKGFTSIMPWLAVNEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELISLMEKHGIGTDA
        VCQHF+G++S +CKYIRTK++ SI GE F+CTG RV  KGFT+IMPW AV+EKKLP FLKGE+IEV RV+LY+GNT PPDYL+ESELISLMEKHGIGTDA
Subjt:  VCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVIVKGFTSIMPWLAVNEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELISLMEKHGIGTDA

Query:  SIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEQQITLVAKGQADHSSVVQNVLQQFKQKYSYFVEKIDHMDALFEAQFS
        SI VHINNIGERNYVQVQ+GR++VPT LGITLIRGYQCIDPDLCLPDIRSFIEQQITLVAKGQADHS VVQ+V+QQF++K+SYFV++I+HMDALFEAQFS
Subjt:  SIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEQQITLVAKGQADHSSVVQNVLQQFKQKYSYFVEKIDHMDALFEAQFS

Query:  PLADSGRALSKCGKCLRYMKFISSQPQRLYCSICEEVYYLPQKGAIKLYKELTCPLDNFELLIFSLPGPEGKSFPLCPYCYNSPPFEGIDTLYGAAKTNP
        PLADSGRALSKCGKCLRYMK I++ P RL+C  CEEVYYLPQKG +KLYKELTCPLDNFEL+I+S+PGPEGKSFPLCPYCYNSPPFEGIDTL+GA+KT  
Subjt:  PLADSGRALSKCGKCLRYMKFISSQPQRLYCSICEEVYYLPQKGAIKLYKELTCPLDNFELLIFSLPGPEGKSFPLCPYCYNSPPFEGIDTLYGAAKTNP

Query:  SSGALSKGMGMPCFLCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPQGAHRISTTNEKCADCDSTIIEVDFNKKTTPLEDGA
        +      G GMPC LCPHPTC+HS+  QGVCACPEC GTLVLDPVS P WKLNCN C+C+V LP+GAHRI+TT+ +C +CDS IIE+DFNKKTTPLE+GA
Subjt:  SSGALSKGMGMPCFLCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPQGAHRISTTNEKCADCDSTIIEVDFNKKTTPLEDGA

Query:  TLFVGCILCDEFLHSLLEMKHGKSFFRGRGSRGRGRGRGRGRGGRGRGRNSGKPMDPKMSFRDF
        TL  GC+LCDE L SL+E+KHG+SF R RG RGRGRGRGRGRG    GR   K +DPKMSFRDF
Subjt:  TLFVGCILCDEFLHSLLEMKHGKSFFRGRGSRGRGRGRGRGRGGRGRGRNSGKPMDPKMSFRDF

O95985 DNA topoisomerase 3-beta-1

1.9e-246

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Query:  TVLMVAEKPSIALSIASALSHGQMSTRK---GSTDVHEFDGRFLGYHAHYKVTSVIGHVFSIDFPAGFQDWKTTDPLDLF-QASVIKTESNPKFLL----
        TVLMVAEKPS+A SIA  LS G +S+ K   G+  VHE+ G F G    +K+TSV GHV ++DF   +  W   DP +LF QA   K E+NPK  +    
Subjt:  TVLMVAEKPSIALSIASALSHGQMSTRK---GSTDVHEFDGRFLGYHAHYKVTSVIGHVFSIDFPAGFQDWKTTDPLDLF-QASVIKTESNPKFLL----

Query:  -------------------GPLVCFVLLIRFLLVLLAVIECTGFGGNEIRKKVYRARFSSVTEKDILKALDNLVQPNRNEALAVDARQEIDLKVGVAFTR
                           G  +CF +L   L V+         GG    K V+RARFSS+T+ DI  A+  L +P+ NEAL+VDARQE+DL++G AFTR
Subjt:  -------------------GPLVCFVLLIRFLLVLLAVIECTGFGGNEIRKKVYRARFSSVTEKDILKALDNLVQPNRNEALAVDARQEIDLKVGVAFTR

Query:  FQTTFFQGKYGNLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYI-MQNGYELNLDWERGKLFDCDVTAMFQKRVMEDGIAEVTEISEKQEN
        FQT +FQGKYG+LDS LIS+GPCQTPTLGFCV+RH +I +FKPE +W +   +       L LDW+R ++FD ++  MF      +  A+V   S K++ 
Subjt:  FQTTFFQGKYGNLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYI-MQNGYELNLDWERGKLFDCDVTAMFQKRVMEDGIAEVTEISEKQEN

Query:  KVRPSGLNTVNLLKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHSLVKNPEWGDYVRMFLSDGYSKPRSGTDVGDHPPITPMC
        K RP  LNTV +L+VASS+LG GPQ AMQ AERLYTQG+ISYPRTE+T YP +FD KG+L     +P W D V+  L++G ++PR G D GDHPPITPM 
Subjt:  KVRPSGLNTVNLLKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHSLVKNPEWGDYVRMFLSDGYSKPRSGTDVGDHPPITPMC

Query:  LATEDMLGRDAWRLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVIVKGFTSIMPWLAVN-EKKLPQFLKGEKIEVARVDLYQGNTTPPDYL
         ATE  LG DAWRLY+Y+ +HFI ++S DCKY+++ I F I  E+F C+G  V+  GFT +MPW +V  E+ LP   +G+   V  V + +  T PPDYL
Subjt:  LATEDMLGRDAWRLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVIVKGFTSIMPWLAVN-EKKLPQFLKGEKIEVARVDLYQGNTTPPDYL

Query:  SESELISLMEKHGIGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEQQITLVAKGQADHSSVVQNVLQQFKQKYS
        +E+ELI+LMEKHGIGTDASIPVHINNI +RNYV V++GRRL PTNLGI L+ GY  ID +L LP IRS +E+Q+ L+A+G+AD+  V+ + L  FK+K+ 
Subjt:  SESELISLMEKHGIGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEQQITLVAKGQADHSSVVQNVLQQFKQKYS

Query:  YFVEKIDHMDALFEAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCSICEEVYYLPQKGAIKLYKELTCPLDNFELLIFSLPGPEGKSFPLCPYCYN
        YFV+ I  MD L E  FSPLA +G+ LS+CGKC R+MK+I ++P RL+CS C+E Y LPQ G IKLYKEL CPLD+FEL+++S  G  GKS+PLCPYCYN
Subjt:  YFVEKIDHMDALFEAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCSICEEVYYLPQKGAIKLYKELTCPLDNFELLIFSLPGPEGKSFPLCPYCYN

Query:  SPPFEGIDTLYGAAKTNPSSGALSKGMGMPCFLCPHPTCRHSLITQGVCACPEC-SGTLVLDPVSAPNWKLNCNKCNCLVFLPQGAHRISTTNEKCADCD
         PPF                  + KGMG  C  C HP+C+HSL   G+  C EC SG LVLDP S P WK+ CNKCN +    + AHR+  + + C+ C+
Subjt:  SPPFEGIDTLYGAAKTNPSSGALSKGMGMPCFLCPHPTCRHSLITQGVCACPEC-SGTLVLDPVSAPNWKLNCNKCNCLVFLPQGAHRISTTNEKCADCD

Query:  STIIEVDFNKKTTPLEDGATLFVGCILCDEFLHSLLEMKHGKSFF-RGRGSRGRGRGRGRGRGGRGRGRNSGKPMDPKMS
        + +++VDFNK  +PL    T  +GC+ CD     L+E+KH  S     RG  GR +GRGRGR  R  G+ + +    KMS
Subjt:  STIIEVDFNKKTTPLEDGATLFVGCILCDEFLHSLLEMKHGKSFF-RGRGSRGRGRGRGRGRGGRGRGRNSGKPMDPKMS

O96651 DNA topoisomerase 3-beta

3.4e-219

46.45

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Query:  TVLMVAEKPSIALSIASALSHGQMSTRKGS---TDVHEFDGRFLGY-HAHYKVTSVIGHVFSIDFPAGFQDWKTTDPLDLFQASVIKTESNPKFLLGPLV
        +VLMVAEKPS+A S+A  LS+G+ + ++G+      HE+ G F      H+++TSV GHV S+DF   +  W   DP+ LF  +  K E+NPK  +   +
Subjt:  TVLMVAEKPSIALSIASALSHGQMSTRKGS---TDVHEFDGRFLGY-HAHYKVTSVIGHVFSIDFPAGFQDWKTTDPLDLFQASVIKTESNPKFLLGPLV

Query:  CFVLLIRFLLVLLAVIECTGFGGN---EIRKKV-------------YRARFSSVTEKDILKALDNLVQPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQ
              R    L+  ++C   G N   E+   V             YRA FS++TEKDI KA++ L  PN NEA +VDARQE+DL++G AFTRFQT FFQ
Subjt:  CFVLLIRFLLVLLAVIECTGFGGN---EIRKKV-------------YRARFSSVTEKDILKALDNLVQPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQ

Query:  GKYGNLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYIMQNGYELNLDWERGKLFDCDVTAMFQKRVMEDGIAEVTEISEKQENKVRPSGLN
         +YG+LDS LISYGPCQTPTLGFCV+RH  I TFKPE FW +   ++    E+ L+W RG++F  D+  M   RV E   A V  ++ K+  K +P  LN
Subjt:  GKYGNLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYIMQNGYELNLDWERGKLFDCDVTAMFQKRVMEDGIAEVTEISEKQENKVRPSGLN

Query:  TVNLLKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHSLVKNPEWGDYVRMFLSDGYSKPRSGTDVGDHPPITPMCLATEDMLG
        TV L+++ SS LG GP  AMQ+AERLYTQG+ISYPRTE+  YP++FD    LH L  + ++G+  R  L D    PR G D GDHPPITPM L       
Subjt:  TVNLLKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHSLVKNPEWGDYVRMFLSDGYSKPRSGTDVGDHPPITPMCLATEDMLG

Query:  RDAWRLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVIVKGFTSIMPWLAV-NEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELISL
        RD WR+Y+++C+HF+G++S D KY  T  + S+  E F+CT S +I  GFT +M W A   ++  P F++G ++ +  V L +  T PPDYL+ESELI+L
Subjt:  RDAWRLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVIVKGFTSIMPWLAV-NEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELISL

Query:  MEKHGIGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEQQITLVAKGQADHSSVVQNVLQQFKQKYSYFVEKIDH
        ME+HGIGTDASIPVHINNI +RNYV ++ GR+L+PT LGI L+ GYQ IDP+L LP +R+ +E+ +TL+A+G A+   V+++ ++ FK K+ YFV+ ID 
Subjt:  MEKHGIGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEQQITLVAKGQADHSSVVQNVLQQFKQKYSYFVEKIDH

Query:  MDALFEAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCSICEEVYYLPQKGAIKLYKELTCPLDNFELLIFSLPGPEGKSFPLCPYCYNSPPFEGID
        MDALFE  FSPLA+SG+A S+CGKC RYMK+I ++P RL+CS C+E Y LP  G +K+Y+E  CPLD+F+LL FS  G +G+S+P CPYCYN PPF  + 
Subjt:  MDALFEAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCSICEEVYYLPQKGAIKLYKELTCPLDNFELLIFSLPGPEGKSFPLCPYCYNSPPFEGID

Query:  TLYGAAKTNPSSGALSKGMGMPCFLCPHPTCRHSLITQGVCACPEC-SGTLVLDPVSAPNWKLNCNKCNCLVFLPQGAHRISTTNEKCADCDSTIIEVDF
         L G                  C  C +  C HSL T G+ +C EC +G LVLD   AP WKL CN+C+ ++   +GA +I+    KC +C +  + V +
Subjt:  TLYGAAKTNPSSGALSKGMGMPCFLCPHPTCRHSLITQGVCACPEC-SGTLVLDPVSAPNWKLNCNKCNCLVFLPQGAHRISTTNEKCADCDSTIIEVDF

Query:  NKKTTPLEDGATLFVGCILCDEFLHSLLEMKHGKSFFRGRGSRGRGRGRGRGRGGRGRG
            +  +DG+    GCI C      L+E KH     R   S G  RG   GRGG G G
Subjt:  NKKTTPLEDGATLFVGCILCDEFLHSLLEMKHGKSFFRGRGSRGRGRGRGRGRGGRGRG

Q0J0S6 DNA topoisomerase 3-beta

0.0e+00

70.74

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Query:  VASTVLMVAEKPSIALSIASALSHGQMSTRKGSTDVHEFDGRFLGYHAHYKVTSVIGHVFSIDFPAGFQDWKTTDPLDLFQASVIKTESNPK-----FLL
        +A TVLMVAEKPSIALSIASALS G+MSTRKGSTDVHEFDG F G HA +KVTSVIGHV S+DFP  +Q+W+ TDP+DLF A V+++E NPK      L 
Subjt:  VASTVLMVAEKPSIALSIASALSHGQMSTRKGSTDVHEFDGRFLGYHAHYKVTSVIGHVFSIDFPAGFQDWKTTDPLDLFQASVIKTESNPK-----FLL

Query:  GPLVCFVLLIRFL-------LVLLAVIECTGFGGNEIRKKVYRARFSSVTEKDILKALDNLVQPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYGN
                L+ +L        +   VI+CTG   +E+ ++++RA+FSSVTEKDI+ A++NLV P+++EALAVDARQEIDLKVGVAFTRFQT +FQGKYGN
Subjt:  GPLVCFVLLIRFL-------LVLLAVIECTGFGGNEIRKKVYRARFSSVTEKDILKALDNLVQPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYGN

Query:  LDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYIMQNGYELNLDWERGKLFDCDVTAMFQKRVMEDGIAEVTEISEKQENKVRPSGLNTVNLL
        LDSR+ISYGPCQTPTLGFCVQR+ QITTFKPEKFWS+  Y++++G E+ L+W+R KLFD DVT MFQK V  DGI +VT+IS K+E K RP GLNTVNLL
Subjt:  LDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYIMQNGYELNLDWERGKLFDCDVTAMFQKRVMEDGIAEVTEISEKQENKVRPSGLNTVNLL

Query:  KVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHSLVKNPEWGDYVRMFLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAWR
        KVASSALG GPQ AM LAERLYTQGFISYPRTESTAYPSSFDF+  L +L  NP W + VR  L  G+ KP+ G D GDHPPITPM LATE+ LG DAWR
Subjt:  KVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHSLVKNPEWGDYVRMFLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAWR

Query:  LYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVIVKGFTSIMPWLAVNEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELISLMEKHGI
        LYQY+CQHFIG++S DC+Y RT I+F+  GE F+C G+RV  KGFTSIMPWLAV+E  +P + KG+ + + +VD+Y+G+TTPPDYLSESELISLMEK+GI
Subjt:  LYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVIVKGFTSIMPWLAVNEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELISLMEKHGI

Query:  GTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEQQITLVAKGQADHSSVVQNVLQQFKQKYSYFVEKIDHMDALFE
        GTDASIPVH+NNI ERNYVQV +GRRLVPT LG TLIRGYQCID DLCLPDIR FIEQQITL+AKG+ADH  VVQ+VLQQF +KYSYFV+KI++MDALFE
Subjt:  GTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEQQITLVAKGQADHSSVVQNVLQQFKQKYSYFVEKIDHMDALFE

Query:  AQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCSICEEVYYLPQKGAIKLYKELTCPLDNFELLIFSLPGPEGKSFPLCPYCYNSPPFEGIDTLYGAA
        AQFSPLADSGR LSKCGKC RYMK+IS+QP RLYC  CEEVYYLPQ G+IKLYKE+ CPLD FELL+FS+ GP+ KSFPLCP+CYNSPPFEGID L+GA 
Subjt:  AQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCSICEEVYYLPQKGAIKLYKELTCPLDNFELLIFSLPGPEGKSFPLCPYCYNSPPFEGIDTLYGAA

Query:  KTNPSSGALSKGMGMPCFLCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPQGAHRISTTNEKCADCDSTIIEVDFNKKTTPL
        K +  +G + KG GMPCFLC HPTC+ S+ITQGVCACPEC+GTL+LDPVSAP W+L CN+CNC+V LP  AH+ISTT++KC  C+STIIEVDFNKKTTPL
Subjt:  KTNPSSGALSKGMGMPCFLCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPQGAHRISTTNEKCADCDSTIIEVDFNKKTTPL

Query:  EDGATLFVGCILCDEFLHSLLEMKHGKSFFRGRGSRGRGRGRGRGRGGRGRGRNSGKPMDPKMSFRDF
        +DGATL  GCILCDE LHSL+EMKHGKSFF  RG RGRGRGRGRGRG     R S +  DPKMSFRDF
Subjt:  EDGATLFVGCILCDEFLHSLLEMKHGKSFFRGRGSRGRGRGRGRGRGGRGRGRNSGKPMDPKMSFRDF

Q9Z321 DNA topoisomerase 3-beta-1

2.7e-248

50.57

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Query:  TVLMVAEKPSIALSIASALSHGQMSTRK---GSTDVHEFDGRFLGYHAHYKVTSVIGHVFSIDFPAGFQDWKTTDPLDLF-QASVIKTESNPKFLL----
        TVLMVAEKPS+A SIA  LS G MS+ K   G+  VH++ G F G   H+K+TSV GHV ++DF   +  W   DP +LF QA   K E+NPK  +    
Subjt:  TVLMVAEKPSIALSIASALSHGQMSTRK---GSTDVHEFDGRFLGYHAHYKVTSVIGHVFSIDFPAGFQDWKTTDPLDLF-QASVIKTESNPKFLL----

Query:  -------------------GPLVCFVLLIRFLLVLLAVIECTGFGGNEIRKKVYRARFSSVTEKDILKALDNLVQPNRNEALAVDARQEIDLKVGVAFTR
                           G  +CF +L   L V+           +   K V+RARFSS+T+ DI  A+  L +P+ NEAL+VDARQE+DL++G AFTR
Subjt:  -------------------GPLVCFVLLIRFLLVLLAVIECTGFGGNEIRKKVYRARFSSVTEKDILKALDNLVQPNRNEALAVDARQEIDLKVGVAFTR

Query:  FQTTFFQGKYGNLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYIMQNGYE-LNLDWERGKLFDCDVTAMFQKRVMEDGIAEVTEISEKQEN
        FQT +FQGKYG+LDS LIS+GPCQTPTLGFCV+RH +I +FKPE +W +   +  +  E L LDW+R ++FD ++  MF      +  A V   S K++ 
Subjt:  FQTTFFQGKYGNLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYIMQNGYE-LNLDWERGKLFDCDVTAMFQKRVMEDGIAEVTEISEKQEN

Query:  KVRPSGLNTVNLLKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHSLVKNPEWGDYVRMFLSDGYSKPRSGTDVGDHPPITPMC
        K RP  LNTV +L+VASSALG GPQ AMQ+AERLYTQG+ISYPRTE+T YP +FD KG+L     +P W D V+  L++G ++PR G D GDHPPITPM 
Subjt:  KVRPSGLNTVNLLKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHSLVKNPEWGDYVRMFLSDGYSKPRSGTDVGDHPPITPMC

Query:  LATEDMLGRDAWRLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVIVKGFTSIMPWLAVN-EKKLPQFLKGEKIEVARVDLYQGNTTPPDYL
         ATE  LG DAWRLY+Y+ +HFI ++S DCKY+++ I F I  E F C G  VI  GFT IMPW +V  E+ LP   KG+   V  V + +  T+PPDYL
Subjt:  LATEDMLGRDAWRLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVIVKGFTSIMPWLAVN-EKKLPQFLKGEKIEVARVDLYQGNTTPPDYL

Query:  SESELISLMEKHGIGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEQQITLVAKGQADHSSVVQNVLQQFKQKYS
        +E+ELI+LMEKHGIGTDASIPVHINNI +RNYV V++GRRL PTNLGI L+ GY  ID +L LP IRS +E+Q+ L+A+G+AD+  V+ + L  FK+K+ 
Subjt:  SESELISLMEKHGIGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEQQITLVAKGQADHSSVVQNVLQQFKQKYS

Query:  YFVEKIDHMDALFEAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCSICEEVYYLPQKGAIKLYKELTCPLDNFELLIFSLPGPEGKSFPLCPYCYN
        YFV+ I  MD L E  FSPLA +G+ LS+CGKC R+MK+I ++P RL+CS C+E Y LPQ G IKLYKEL CPLD+FEL+++S  G  GKS+PLCPYCYN
Subjt:  YFVEKIDHMDALFEAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCSICEEVYYLPQKGAIKLYKELTCPLDNFELLIFSLPGPEGKSFPLCPYCYN

Query:  SPPFEGIDTLYGAAKTNPSSGALSKGMGMPCFLCPHPTCRHSLITQGVCACPEC-SGTLVLDPVSAPNWKLNCNKCNCLVFLPQGAHRISTTNEKCADCD
         PPF                  + KGMG  C  C HPTC+HSL   G+  C EC +G LVLDP S P WK+ CN CN +    + AHR+  + + C  C+
Subjt:  SPPFEGIDTLYGAAKTNPSSGALSKGMGMPCFLCPHPTCRHSLITQGVCACPEC-SGTLVLDPVSAPNWKLNCNKCNCLVFLPQGAHRISTTNEKCADCD

Query:  STIIEVDFNKKTTPLEDGATLFVGCILCDEFLHSLLEMKHGKSFF-RGRGSRGRGRGRGRGRGGRGRGRNSGKPMDPKMS
        + +++VDFNK  +PL    T   GCI CD     L+E+KH  S     RG  GR +GRGRGRG R  G+ + +    KMS
Subjt:  STIIEVDFNKKTTPLEDGATLFVGCILCDEFLHSLLEMKHGKSFF-RGRGSRGRGRGRGRGRGGRGRGRNSGKPMDPKMS

Arabidopsis top hits

e value

%identity

Alignment

AT2G32000.1 DNA topoisomerase, type IA, core

0.0e+00

73.5

Show/hide

Query:  VLMVAEKPSIALSIASALSHGQMSTRKGSTDVHEFDGRFLGYHAHYKVTSVIGHVFSIDFPAGFQDWKTTDPLDLFQASVIKTESNPK-----FLLGPLV
        VLMVAEKPSIALSIAS LSHGQMSTR+GST+VHEFDG F G+ AHY+VTSVIGHVFS+DFP  +Q+W T DP DLF A +IK ESNPK      L     
Subjt:  VLMVAEKPSIALSIASALSHGQMSTRKGSTDVHEFDGRFLGYHAHYKVTSVIGHVFSIDFPAGFQDWKTTDPLDLFQASVIKTESNPK-----FLLGPLV

Query:  CFVLLIRFL-------LVLLAVIECTGFGGNEIRKKVYRARFSSVTEKDILKALDNLVQPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYGNLDSR
            ++ +L        +   VIE TGF   + ++KVYRARFSSVTEKDI KA+DNLV+PNR+EALAVDARQEIDLKVGVAF+RFQT++FQGKY NLD R
Subjt:  CFVLLIRFL-------LVLLAVIECTGFGGNEIRKKVYRARFSSVTEKDILKALDNLVQPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYGNLDSR

Query:  LISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYIMQNGYELNLDWERGKLFDCDVTAMFQKRVMEDGIAEVTEISEKQENKVRPSGLNTVNLLKVAS
        +ISYGPCQTPTLGFCVQR++ I TFKPEKFW++ PYI ++GYEL L+WER +LFD +   +FQK V+E   A+V ++SEKQE K RP+GLNTVNLLKVAS
Subjt:  LISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYIMQNGYELNLDWERGKLFDCDVTAMFQKRVMEDGIAEVTEISEKQENKVRPSGLNTVNLLKVAS

Query:  SALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHSLVKNPEWGDYVRMFLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAWRLYQY
        SALGFGPQ AM LAERLYTQGFISYPRTESTAYPSSFDF  TL + V NP WG YV+  LSDG+  P+SGTD GDHPPITPM  ATE M+G DAWRLYQY
Subjt:  SALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHSLVKNPEWGDYVRMFLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAWRLYQY

Query:  VCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVIVKGFTSIMPWLAVNEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELISLMEKHGIGTDA
        VCQHF+G++S +CKYIRTK++ SI GE F+CTG RV  KGFT+IMPW AV+EKKLP FLKGE+IEV RV+LY+GNT PPDYL+ESELISLMEKHGIGTDA
Subjt:  VCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVIVKGFTSIMPWLAVNEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELISLMEKHGIGTDA

Query:  SIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEQQITLVAKGQADHSSVVQNVLQQFKQKYSYFVEKIDHMDALFEAQFS
        SI VHINNIGERNYVQVQ+GR++VPT LGITLIRGYQCIDPDLCLPDIRSFIEQQITLVAKGQADHS VVQ+V+QQF++K+SYFV++I+HMDALFEAQFS
Subjt:  SIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEQQITLVAKGQADHSSVVQNVLQQFKQKYSYFVEKIDHMDALFEAQFS

Query:  PLADSGRALSKCGKCLRYMKFISSQPQRLYCSICEEVYYLPQKGAIKLYKELTCPLDNFELLIFSLPGPEGKSFPLCPYCYNSPPFEGIDTLYGAAKTNP
        PLADSGRALSKCGKCLRYMK I++ P RL+C  CEEVYYLPQKG +KLYKELTCPLDNFEL+I+S+PGPEGKSFPLCPYCYNSPPFEGIDTL+GA+KT  
Subjt:  PLADSGRALSKCGKCLRYMKFISSQPQRLYCSICEEVYYLPQKGAIKLYKELTCPLDNFELLIFSLPGPEGKSFPLCPYCYNSPPFEGIDTLYGAAKTNP

Query:  SSGALSKGMGMPCFLCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPQGAHRISTTNEKCADCDSTIIEVDFNKKTTPLEDGA
        +      G GMPC LCPHPTC+HS+  QGVCACPEC GTLVLDPVS P WKLNCN C+C+V LP+GAHRI+TT+ +C +CDS IIE+DFNKKTTPLE+GA
Subjt:  SSGALSKGMGMPCFLCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPQGAHRISTTNEKCADCDSTIIEVDFNKKTTPLEDGA

Query:  TLFVGCILCDEFLHSLLEMKHGKSFFRGRGSRGRGRGRGRGRGGRGRGRNSGKPMDPKMSFRDF
        TL  GC+LCDE L SL+E+KHG+SF R RG RGRGRGRGRGRG    GR   K +DPKMSFRDF
Subjt:  TLFVGCILCDEFLHSLLEMKHGKSFFRGRGSRGRGRGRGRGRGGRGRGRNSGKPMDPKMSFRDF

AT2G32000.2 DNA topoisomerase, type IA, core

0.0e+00

72.24

Show/hide

Query:  HVFSI---DFPAGFQDWKTTDPLDLFQASVIKTESNPK-----FLLGPLVCFVLLIRFL-------LVLLAVIECTGFGGNEIRKKVYRARFSSVTEKDI
        H+ S+   DFP  +Q+W T DP DLF A +IK ESNPK      L         ++ +L        +   VIE TGF   + ++KVYRARFSSVTEKDI
Subjt:  HVFSI---DFPAGFQDWKTTDPLDLFQASVIKTESNPK-----FLLGPLVCFVLLIRFL-------LVLLAVIECTGFGGNEIRKKVYRARFSSVTEKDI

Query:  LKALDNLVQPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYGNLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYIMQNGYELNLDWER
         KA+DNLV+PNR+EALAVDARQEIDLKVGVAF+RFQT++FQGKY NLD R+ISYGPCQTPTLGFCVQR++ I TFKPEKFW++ PYI ++GYEL L+WER
Subjt:  LKALDNLVQPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYGNLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSVCPYIMQNGYELNLDWER

Query:  GKLFDCDVTAMFQKRVMEDGIAEVTEISEKQENKVRPSGLNTVNLLKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHSLVKNP
         +LFD +   +FQK V+E   A+V ++SEKQE K RP+GLNTVNLLKVASSALGFGPQ AM LAERLYTQGFISYPRTESTAYPSSFDF  TL + V NP
Subjt:  GKLFDCDVTAMFQKRVMEDGIAEVTEISEKQENKVRPSGLNTVNLLKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHSLVKNP

Query:  EWGDYVRMFLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAWRLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVIVKGFTSIMPWLAV
         WG YV+  LSDG+  P+SGTD GDHPPITPM  ATE M+G DAWRLYQYVCQHF+G++S +CKYIRTK++ SI GE F+CTG RV  KGFT+IMPW AV
Subjt:  EWGDYVRMFLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAWRLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVIVKGFTSIMPWLAV

Query:  NEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELISLMEKHGIGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRS
        +EKKLP FLKGE+IEV RV+LY+GNT PPDYL+ESELISLMEKHGIGTDASI VHINNIGERNYVQVQ+GR++VPT LGITLIRGYQCIDPDLCLPDIRS
Subjt:  NEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELISLMEKHGIGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRS

Query:  FIEQQITLVAKGQADHSSVVQNVLQQFKQKYSYFVEKIDHMDALFEAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCSICEEVYYLPQKGAIKLYK
        FIEQQITLVAKGQADHS VVQ+V+QQF++K+SYFV++I+HMDALFEAQFSPLADSGRALSKCGKCLRYMK I++ P RL+C  CEEVYYLPQKG +KLYK
Subjt:  FIEQQITLVAKGQADHSSVVQNVLQQFKQKYSYFVEKIDHMDALFEAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCSICEEVYYLPQKGAIKLYK

Query:  ELTCPLDNFELLIFSLPGPEGKSFPLCPYCYNSPPFEGIDTLYGAAKTNPSSGALSKGMGMPCFLCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNW
        ELTCPLDNFEL+I+S+PGPEGKSFPLCPYCYNSPPFEGIDTL+GA+KT  +      G GMPC LCPHPTC+HS+  QGVCACPEC GTLVLDPVS P W
Subjt:  ELTCPLDNFELLIFSLPGPEGKSFPLCPYCYNSPPFEGIDTLYGAAKTNPSSGALSKGMGMPCFLCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNW

Query:  KLNCNKCNCLVFLPQGAHRISTTNEKCADCDSTIIEVDFNKKTTPLEDGATLFVGCILCDEFLHSLLEMKHGKSFFRGRGSRGRGRGRGRGRGGRGRGRN
        KLNCN C+C+V LP+GAHRI+TT+ +C +CDS IIE+DFNKKTTPLE+GATL  GC+LCDE L SL+E+KHG+SF R RG RGRGRGRGRGRG    GR 
Subjt:  KLNCNKCNCLVFLPQGAHRISTTNEKCADCDSTIIEVDFNKKTTPLEDGATLFVGCILCDEFLHSLLEMKHGKSFFRGRGSRGRGRGRGRGRGGRGRGRN

Query:  SGKPMDPKMSFRDF
          K +DPKMSFRDF
Subjt:  SGKPMDPKMSFRDF

AT5G63920.1 topoisomerase 3alpha

1.5e-92

34.34

Show/hide

Query:  TVLMVAEKPSIALSIASALSHGQMSTRKGST---DVHEFDGRFLGYHAHYKVTSVIGHVFSIDFPAGFQDWKTTDPLDLFQASVIKTESNPKFLLGPLVC
        TVL VAEKPS+A S+A  LS G   TR+G +    + EFD    G      +TSVIGH+  ++F   ++ W + DP DL+QA V+K     K  +   + 
Subjt:  TVLMVAEKPSIALSIASALSHGQMSTRKGST---DVHEFDGRFLGYHAHYKVTSVIGHVFSIDFPAGFQDWKTTDPLDLFQASVIKTESNPKFLLGPLVC

Query:  FVLLIRFLLVLLAVIECTGFGGN----------EIRKKVY--RARFSSVTEKDILKALDNLVQPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKY--
                LVL   ++C   G N           ++  ++  RA FS++ ++DI +A+ NL  PN+  A AVDARQEIDL++G +FTRFQT   + ++  
Subjt:  FVLLIRFLLVLLAVIECTGFGGN----------EIRKKVY--RARFSSVTEKDILKALDNLVQPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKY--

Query:  ---GNLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSV-CPYIMQNGYELNLDWERGKLFDCDVTAMFQKRVMEDGIAEVTEISEKQEN-KVRPSG
           G   SR+ISYGPCQ PTLGF V+R+ +I   +PE+FW++ C +  + G     +W RG LFD     +  +  +E+  A V  +   +E  K  P  
Subjt:  ---GNLDSRLISYGPCQTPTLGFCVQRHLQITTFKPEKFWSV-CPYIMQNGYELNLDWERGKLFDCDVTAMFQKRVMEDGIAEVTEISEKQEN-KVRPSG

Query:  LNTVNLLKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHSLVKNPEWGDYVRMFLSD----GYSKPRSGTDVGDHPPITPMCLA
        LNT+ L K AS       +  M++AE LY  GFISYPRTE+ ++ S  D +  +    ++P WG Y +  L        +    G D   HPPI P   +
Subjt:  LNTVNLLKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHSLVKNPEWGDYVRMFLSD----GYSKPRSGTDVGDHPPITPMCLA

Query:  T-EDMLGRDAWRLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVIVKGFTSIMPWLAVNEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSE
        + E    RD   +Y+ V +H++  +S       T ++  IAGE F+ +G  ++ K +  +  + +     +P + KG++     + L    T PP  L E
Subjt:  T-EDMLGRDAWRLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVIVKGFTSIMPWLAVNEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSE

Query:  SELISLMEKHGIGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEQQITLVAKGQADHSSVVQNVLQQFK
        ++L+S M+K GIGTDA++  HI  + +R Y    A  R  PTNLG  L+ GY  +  +L  P++R+ +E  +  V+ G+   + V++  LQQ K
Subjt:  SELISLMEKHGIGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEQQITLVAKGQADHSSVVQNVLQQFK

Sequences

Show/hide sequences

CDS sequence

Show/hide CDS sequence

ATGGTTGCTTCAACGGTTCTTATGGTGGCAGAGAAGCCTAGCATTGCGCTCTCAATTGCTTCTGCACTCTCTCATGGCCAAATGTCTACAAGAAAGGGTAGCACAGATGT
ACATGAATTCGATGGGAGATTTCTTGGGTATCATGCTCATTATAAAGTGACATCAGTTATCGGACATGTTTTCAGTATAGATTTCCCTGCTGGATTTCAAGATTGGAAGA
CCACTGATCCTTTGGATCTTTTTCAAGCTTCAGTAATTAAGACAGAGTCAAACCCAAAGTTTCTTTTGGGACCACTGGTTTGTTTTGTTTTGCTTATTAGATTTCTATTG
GTTCTGCTTGCAGTTATTGAGTGCACTGGATTTGGTGGCAATGAAATTAGGAAAAAAGTGTATCGTGCAAGGTTTTCTTCCGTTACTGAAAAAGATATTCTGAAGGCTTT
GGATAACCTTGTTCAACCTAATAGAAATGAGGCACTGGCTGTTGATGCTCGACAAGAGATAGATTTGAAAGTTGGAGTAGCCTTTACACGATTTCAGACTACCTTTTTTC
AGGGAAAATATGGAAACCTTGATTCCAGACTCATCTCCTATGGGCCATGCCAAACTCCCACGCTTGGGTTTTGTGTACAGCGTCATTTGCAAATAACTACCTTTAAGCCA
GAAAAATTTTGGTCTGTGTGCCCTTATATTATGCAAAACGGCTATGAACTTAATCTGGACTGGGAACGGGGCAAGTTATTCGACTGTGATGTTACTGCAATGTTTCAAAA
GCGAGTAATGGAAGATGGAATTGCAGAAGTAACAGAAATATCAGAGAAGCAAGAAAACAAAGTTCGACCTTCTGGACTAAATACAGTTAACCTTCTGAAGGTTGCTTCAA
GCGCACTAGGATTTGGACCTCAAATGGCAATGCAACTAGCCGAACGATTGTATACGCAAGGGTTCATCAGCTATCCACGTACAGAAAGTACGGCTTATCCTTCTTCATTT
GACTTCAAAGGGACTCTACATTCCCTAGTGAAAAATCCAGAATGGGGTGATTATGTACGGATGTTTCTATCTGATGGATACAGTAAACCACGATCAGGAACTGACGTAGG
TGATCATCCTCCTATTACTCCAATGTGTTTAGCAACTGAAGATATGCTAGGGAGAGATGCTTGGAGATTGTACCAATACGTGTGTCAACACTTCATTGGGTCTCTGTCTT
CTGACTGCAAGTATATTAGGACGAAGATACAGTTTTCAATAGCTGGAGAAATATTCAATTGTACTGGGTCACGTGTTATAGTAAAAGGATTCACCTCCATTATGCCATGG
TTAGCAGTAAATGAAAAAAAACTACCTCAGTTTCTGAAGGGAGAGAAAATAGAAGTTGCAAGAGTGGATCTTTATCAGGGGAACACCACGCCTCCTGATTACTTAAGTGA
GAGTGAGTTGATTTCTCTCATGGAGAAGCATGGAATTGGCACAGATGCATCTATACCTGTACACATTAACAACATAGGCGAGCGCAACTATGTTCAGGTTCAAGCTGGGA
GGAGGTTGGTTCCAACTAACTTGGGCATCACTTTAATCAGAGGTTATCAATGCATTGATCCAGATCTCTGTTTACCAGATATTCGAAGTTTCATTGAGCAACAGATCACT
CTTGTTGCCAAAGGTCAAGCAGATCATTCTAGTGTTGTGCAGAATGTATTGCAACAGTTCAAGCAAAAGTATAGCTACTTCGTTGAGAAGATTGATCATATGGATGCTCT
GTTTGAAGCACAATTTTCTCCCCTTGCTGATTCAGGACGTGCTTTGAGCAAATGTGGCAAATGCCTACGGTATATGAAGTTTATTTCTTCTCAACCACAGCGTCTGTACT
GCAGTATATGTGAGGAGGTTTATTATCTTCCTCAAAAGGGAGCAATAAAGCTGTACAAGGAACTTACATGCCCGTTGGACAACTTCGAGCTCTTGATTTTTTCCTTACCT
GGCCCAGAAGGCAAGTCATTTCCTCTTTGCCCATACTGCTACAATAGTCCTCCATTTGAGGGTATTGACACATTATATGGTGCTGCTAAAACCAACCCAAGTTCCGGAGC
ATTGAGCAAGGGAATGGGCATGCCATGCTTCCTCTGTCCGCACCCAACATGTCGACATTCTTTAATAACCCAAGGAGTTTGTGCTTGCCCGGAATGTAGCGGGACGCTTG
TCCTAGATCCAGTGAGTGCACCCAACTGGAAACTCAACTGCAATAAGTGCAATTGTCTTGTCTTCCTTCCTCAGGGTGCTCATAGGATTTCCACCACAAATGAGAAGTGT
GCTGATTGTGACTCTACAATTATAGAAGTGGACTTCAACAAGAAAACAACACCATTGGAGGATGGAGCTACGTTGTTTGTTGGCTGCATTCTTTGCGATGAGTTTCTCCA
TTCACTTCTGGAGATGAAGCATGGTAAATCATTTTTCAGAGGCAGAGGTTCTAGAGGAAGAGGAAGAGGAAGGGGAAGGGGAAGAGGAGGAAGAGGAAGAGGACGTAATT
CAGGGAAACCGATGGACCCGAAAATGAGTTTCCGAGATTTCTAA

mRNA sequence

Show/hide mRNA sequence

Protein sequence

Show/hide protein sequence

MVASTVLMVAEKPSIALSIASALSHGQMSTRKGSTDVHEFDGRFLGYHAHYKVTSVIGHVFSIDFPAGFQDWKTTDPLDLFQASVIKTESNPKFLLGPLVCFVLLIRFLL
VLLAVIECTGFGGNEIRKKVYRARFSSVTEKDILKALDNLVQPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYGNLDSRLISYGPCQTPTLGFCVQRHLQITTFKP
EKFWSVCPYIMQNGYELNLDWERGKLFDCDVTAMFQKRVMEDGIAEVTEISEKQENKVRPSGLNTVNLLKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSF
DFKGTLHSLVKNPEWGDYVRMFLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAWRLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVIVKGFTSIMPW
LAVNEKKLPQFLKGEKIEVARVDLYQGNTTPPDYLSESELISLMEKHGIGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEQQIT
LVAKGQADHSSVVQNVLQQFKQKYSYFVEKIDHMDALFEAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCSICEEVYYLPQKGAIKLYKELTCPLDNFELLIFSLP
GPEGKSFPLCPYCYNSPPFEGIDTLYGAAKTNPSSGALSKGMGMPCFLCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPQGAHRISTTNEKC
ADCDSTIIEVDFNKKTTPLEDGATLFVGCILCDEFLHSLLEMKHGKSFFRGRGSRGRGRGRGRGRGGRGRGRNSGKPMDPKMSFRDF

HG10012433 (gene) of Bottle gourd (Hangzhou Gourd) v1 genome