; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; CuGenDBv2

HG10019412 (gene) of Bottle gourd (Hangzhou Gourd) v1 genome

Gene IDHG10019412
OrganismLagenaria siceraria cv. Hangzhou Gourd (Bottle gourd (Hangzhou Gourd) v1)
DescriptionDNA topoisomerase 2
Genome locationChr04:21569631..21576678
RNA-Seq ExpressionHG10019412
SyntenyHG10019412
Gene Ontology termsGO:0006265 - DNA topological change (biological process)
GO:0043231 - intracellular membrane-bounded organelle (cellular component)
GO:0003677 - DNA binding (molecular function)
GO:0046872 - metal ion binding (molecular function)
GO:0005524 - ATP binding (molecular function)
GO:0003918 - DNA topoisomerase type II (ATP-hydrolyzing) activity (molecular function)
InterPro domainsIPR013506 - DNA topoisomerase, type IIA, subunit B, domain 2
IPR036890 - Histidine kinase/HSP90-like ATPase superfamily
IPR034157 - DNA topoisomerase 2, TOPRIM domain
IPR031660 - C-terminal associated domain of TOPRIM
IPR020568 - Ribosomal protein S5 domain 2-type fold
IPR018522 - DNA topoisomerase, type IIA, conserved site
IPR014721 - Ribosomal protein S5 domain 2-type fold, subgroup
IPR013760 - DNA topoisomerase, type IIA-like domain superfamily
IPR013759 - DNA topoisomerase, type IIA, subunit B, C-terminal
IPR013758 - DNA topoisomerase, type IIA, subunit A/ C-terminal, alpha-beta
IPR013757 - Type IIA DNA topoisomerase subunit A, alpha-helical domain superfamily
IPR006171 - TOPRIM domain
IPR003594 - Histidine kinase/HSP90-like ATPase
IPR002205 - DNA topoisomerase, type IIA, subunit A/C-terminal
IPR001241 - DNA topoisomerase, type IIA
IPR001154 - DNA topoisomerase II, eukaryotic-type


Homology Show/hide homology
GenBank top hitse value%identityAlignment
KAA0048368.1 DNA topoisomerase 2 [Cucumis melo var. makuwa]0.0e+0093.94Show/hide
Query:  MAVEKKRPLQNSNATNVDSNPAGPKKTIEEMYQKKSQLEHILLRPDTYVGSIEKHTQSLWVYENDKMVHRSISYVPGLYKIFDEILVNAADNKQRDPSMD
        M VEKKRPLQNSN  NVDSNPAGPKKTIEEMYQKKSQLEHILLRPDTYVGSIEKHTQ+LWVYENDKMVHRSISYVPGLYKIFDEILVNAADNKQRDPSMD
Subjt:  MAVEKKRPLQNSNATNVDSNPAGPKKTIEEMYQKKSQLEHILLRPDTYVGSIEKHTQSLWVYENDKMVHRSISYVPGLYKIFDEILVNAADNKQRDPSMD

Query:  SVKVNIDVEQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFNDNMGKKSE
        SVKVNIDVEQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADG+RLKKYKQVFNDNMGKKSE
Subjt:  SVKVNIDVEQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFNDNMGKKSE

Query:  PIITKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASTFQTEPPKRYHIKPNERWEIVV
        PIITKCKEGDNWT+VTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSAS+FQ EPPKRYHIKPNERWEIVV
Subjt:  PIITKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASTFQTEPPKRYHIKPNERWEIVV

Query:  TLSEGQFQQVSFVNGISTIKGGTHVDYITNQIANYVMTVVNKKNKNANVKAHNVKSYLWVFINALIDNPSFDSQTKETLTKRPNSFGSACELTPEFLKNV
        TLSEGQFQQVSFVNGI+TIKGGTHV+YITNQIANYVMT VNKKNKNANVKAHNVK+YLWVFINALIDNPSFDSQTKETLTKR NSFGSACELTPEFLKNV
Subjt:  TLSEGQFQQVSFVNGISTIKGGTHVDYITNQIANYVMTVVNKKNKNANVKAHNVKSYLWVFINALIDNPSFDSQTKETLTKRPNSFGSACELTPEFLKNV

Query:  ATKSGIMDSVLSWVNFKQSKDLKKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQIT
        ATKSGIMDSVLSWVNFKQSKDLKKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQIT
Subjt:  ATKSGIMDSVLSWVNFKQSKDLKKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQIT

Query:  ENKEIQYIKQILGLQQGKEYSNAKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLRVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWRESLR
        ENKEIQYIKQILGLQQGKEY+NAKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLRVPSFLVEFITPIVKATH+NGTVLSFYTMPEYESW+ESLR
Subjt:  ENKEIQYIKQILGLQQGKEYSNAKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLRVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWRESLR

Query:  GNASGWSIKYYKGLGTSTSKEGREYFEQLTKHKKDFIWQDDNDGEAIELAFSKKKIEDRKNWLRQFEPGTHLDQTGRLIKYSDFVNKELILFSMADLQRS
        GNASGWSIKYYKGLGTSTSKEGREYFEQLTKHKKDFIWQDDNDGEAIELAFSKKKIEDRKNWLRQFEPGTHLDQTG+LIKYSDFVNKELILFSMADLQRS
Subjt:  GNASGWSIKYYKGLGTSTSKEGREYFEQLTKHKKDFIWQDDNDGEAIELAFSKKKIEDRKNWLRQFEPGTHLDQTGRLIKYSDFVNKELILFSMADLQRS

Query:  IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT
        IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT
Subjt:  IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT

Query:  RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDIIRNVRRMLDGETMLPMDPWYRGFSGTIEKTATKEGGTSYTVS
        RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDIIRNVRRMLDGETMLPMDPWYRGFSGTIEKTATKEGGT+YT+S
Subjt:  RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDIIRNVRRMLDGETMLPMDPWYRGFSGTIEKTATKEGGTSYTVS

Query:  GIIEEVSDTTLRIIELPVRRWTNDYKDFLDSVTRVASKHDKDKEKAAKDPFIEQADHHSDDKIVSIDVHLTEENMLLAIQEGLKKKFKLTTTVSTSNMHL
        GIIEEVSDTTLRI+ELPVRRWT+DYKDFLDSVTRVASKH  DKEKAAKDPFIEQADHHSDDKIVSIDVHLTEENMLLAIQEGLKKKFKLTTTVSTSNMHL
Subjt:  GIIEEVSDTTLRIIELPVRRWTNDYKDFLDSVTRVASKHDKDKEKAAKDPFIEQADHHSDDKIVSIDVHLTEENMLLAIQEGLKKKFKLTTTVSTSNMHL

Query:  FDANGVIKKYDTPEQILEEFFPLRLEFYEKRKRNLLENLEMELLKLENKVRFILAVVNGEIIVSNRRKVDLFHELQAKGFTPFPKKTKSAEPEVAGASNE
        FDANGVIKKYDTPEQILEEFFPLRLEFYEKRKR LL+NLEMELLKLENKVRFILAVVN EI VSNR+KVDLFHELQAKGFTPFPKKTKS EPE+AGASNE
Subjt:  FDANGVIKKYDTPEQILEEFFPLRLEFYEKRKRNLLENLEMELLKLENKVRFILAVVNGEIIVSNRRKVDLFHELQAKGFTPFPKKTKSAEPEVAGASNE

Query:  TDEAEESPEVVKGERVSDYEYLLAMAIGTLTIEKVQELCNDRDKLKGEVDDLRKATPKSLWLNDLDSLEKELDEMDRNDAQAMEVRKQQRDKSNIDLKPK
        TDEAEESPEVVKGER+SDYEYLLA+ IGTLTIEKVQELCNDRDKLKGEVDDLRKATPKSLWLNDLDSLEKELDE+DRNDAQ ME+RKQQRDK+N DLKPK
Subjt:  TDEAEESPEVVKGERVSDYEYLLAMAIGTLTIEKVQELCNDRDKLKGEVDDLRKATPKSLWLNDLDSLEKELDEMDRNDAQAMEVRKQQRDKSNIDLKPK

Query:  ISRNAPKAPRNSKKTSNAETVPESMDTTSSSTTTEVANNPVVKPKGKAAPRKAPAKKKQPQGKAAVLD-DEDDEVLELKDRLAAYKIESSPEPSEVSVME
        ISRNAPKAPRNSKKTSN ETV ESMDTT SSTTTEVANNPVVKPKGKAAPRKAPAKKK   GKAAV D D+DDEVLELKDRLAAYKIESSPEPSEVS ME
Subjt:  ISRNAPKAPRNSKKTSNAETVPESMDTTSSSTTTEVANNPVVKPKGKAAPRKAPAKKKQPQGKAAVLD-DEDDEVLELKDRLAAYKIESSPEPSEVSVME

Query:  TEVPQVQAAKKKEPSKRAAAKKKTTAKSAQISASDD-DEDDFEIKEVAPPAAKKGGGR----KAAANAKTTKPPAAAAKLGQKLITQMLEPAENSGISPE
        TEV +VQAAKKKEPSKRA AKKKTTAKSAQIS SDD D+DDFEIKEV P AAKKGGGR     AAAN KTTK PAA  KLGQKLITQMLEPAENSGISPE
Subjt:  TEVPQVQAAKKKEPSKRAAAKKKTTAKSAQISASDD-DEDDFEIKEVAPPAAKKGGGR----KAAANAKTTKPPAAAAKLGQKLITQMLEPAENSGISPE

Query:  KKVRKIRASPFNKKSGSILGRTIGEEEEEAGNED--KVVGSASSETTEEVARFPAARGRSQRANRTQVRYVVSDSDND-VSEASDFDEEASLDEEASLDE
        KKVRKIRASPFNKKSGS+LGR I EEEEE G ED  KV+GSASSET+EEVA F  A GRS+RANRTQVRYV+SDSD++ VS+ SDFDE     +EASLDE
Subjt:  KKVRKIRASPFNKKSGSILGRTIGEEEEEAGNED--KVVGSASSETTEEVARFPAARGRSQRANRTQVRYVVSDSDND-VSEASDFDEEASLDEEASLDE

Query:  D
        D
Subjt:  D
KAG7018075.1 DNA topoisomerase 2 [Cucurbita argyrosperma subsp. argyrosperma]0.0e+0092.27Show/hide
Query:  MAVEKKRPLQNSNATNVDSNPAGPKKTIEEMYQKKSQLEHILLRPDTYVGSIEKHTQSLWVYENDKMVHRSISYVPGLYKIFDEILVNAADNKQRDPSMD
        MAVEKKRPLQNSNA NVDS+PAGPKKTIEEMYQKK+QLEHILLRPDTYVGSIEKHTQ+LWVYENDKMVHRS++YVPGLYKIFDEILVNAADNKQRDPSMD
Subjt:  MAVEKKRPLQNSNATNVDSNPAGPKKTIEEMYQKKSQLEHILLRPDTYVGSIEKHTQSLWVYENDKMVHRSISYVPGLYKIFDEILVNAADNKQRDPSMD

Query:  SVKVNIDVEQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFNDNMGKKSE
        S+KV ID EQN ISVFNNGDGVPVE+HQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADG+RLKKYKQVF+DNMGKKSE
Subjt:  SVKVNIDVEQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFNDNMGKKSE

Query:  PIITKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASTFQTEPPKRYHIKPNERWEIVV
        PIITKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVD YLKSA+ FQTEPPKRYHI+PNERWEIVV
Subjt:  PIITKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASTFQTEPPKRYHIKPNERWEIVV

Query:  TLSEGQFQQVSFVNGISTIKGGTHVDYITNQIANYVMTVVNKKNKNANVKAHNVKSYLWVFINALIDNPSFDSQTKETLTKRPNSFGSACELTPEFLKNV
        TLSEGQFQQVSFVNGI+TIKGGTHVDYITNQIANYVMTVVNKKNKNANVKAHNVKSYLWVFINALIDNP+FDSQTKETLT R +SFGSACELTP+FLKNV
Subjt:  TLSEGQFQQVSFVNGISTIKGGTHVDYITNQIANYVMTVVNKKNKNANVKAHNVKSYLWVFINALIDNPSFDSQTKETLTKRPNSFGSACELTPEFLKNV

Query:  ATKSGIMDSVLSWVNFKQSKDLKKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQIT
        ATKSGIMDSVLSWVNFKQSKDLKKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQIT
Subjt:  ATKSGIMDSVLSWVNFKQSKDLKKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQIT

Query:  ENKEIQYIKQILGLQQGKEYSNAKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLRVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWRESLR
        ENKEIQYIKQILGLQQGKEY+NAKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLRVPSFLVEFITPIVKATHRNGTVLSFYTMPEYE+W+++LR
Subjt:  ENKEIQYIKQILGLQQGKEYSNAKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLRVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWRESLR

Query:  GNASGWSIKYYKGLGTSTSKEGREYFEQLTKHKKDFIWQDDNDGEAIELAFSKKKIEDRKNWLRQFEPGTHLDQTGRLIKYSDFVNKELILFSMADLQRS
        GNASGWSIKYYKGLGTSTSKEGREYFEQL KHKKDFIWQD++DGEAIELAFSKKKIE+RKNWLRQFE GTHLDQ+ +LIKYSDFVNKELILFSMADLQRS
Subjt:  GNASGWSIKYYKGLGTSTSKEGREYFEQLTKHKKDFIWQDDNDGEAIELAFSKKKIEDRKNWLRQFEPGTHLDQTGRLIKYSDFVNKELILFSMADLQRS

Query:  IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT
        IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLSN T
Subjt:  IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT

Query:  RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDIIRNVRRMLDGETMLPMDPWYRGFSGTIEKTATKEGGTSYTVS
        RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSY+PNYNPRDIIRNVRRML+GE MLPMDPWYRGFSGTIEKTATKEGGTSYTVS
Subjt:  RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDIIRNVRRMLDGETMLPMDPWYRGFSGTIEKTATKEGGTSYTVS

Query:  GIIEEVSDTTLRIIELPVRRWTNDYKDFLDSVTRVASKHDKDKEKAAKDPFIEQADHHSDDKIVSIDVHLTEENMLLAIQEGLKKKFKLTTTVSTSNMHL
        GIIEEVSDTTLRI ELPVRRWTNDYKDFLDSVTRV++K+DKDKEKAAKDPFIEQADHHSDDK VSIDVHLTEENM+LA+QEGLKKKFKLTTTVSTSNMHL
Subjt:  GIIEEVSDTTLRIIELPVRRWTNDYKDFLDSVTRVASKHDKDKEKAAKDPFIEQADHHSDDKIVSIDVHLTEENMLLAIQEGLKKKFKLTTTVSTSNMHL

Query:  FDANGVIKKYDTPEQILEEFFPLRLEFYEKRKRNLLENLEMELLKLENKVRFILAVVNGEIIVSNRRKVDLFHELQAKGFTPFPKKTKSAEPEVAGASNE
        FDANGVIKKYDTPEQILEEFFPLRLEF+EKRKRNLLENLE ELLKLENKVRFILAVVNGEIIVSNRR+VDLFHELQ KGFTPFPKKTKS EPEVAGASNE
Subjt:  FDANGVIKKYDTPEQILEEFFPLRLEFYEKRKRNLLENLEMELLKLENKVRFILAVVNGEIIVSNRRKVDLFHELQAKGFTPFPKKTKSAEPEVAGASNE

Query:  TDEAEESPEVVKGERVSDYEYLLAMAIGTLTIEKVQELCNDRDKLKGEVDDLRKATPKSLWLNDLDSLEKELDEMDRNDAQAMEVRKQQRDKSNIDLKPK
        TDEAEESPEVVKGERVSDYEYLLA+AIGTLTIEKVQELCN+RDK KGEV++LRKATPKSLWL DLD LEKELDEMDRNDAQA EVRKQQR K+N D+KPK
Subjt:  TDEAEESPEVVKGERVSDYEYLLAMAIGTLTIEKVQELCNDRDKLKGEVDDLRKATPKSLWLNDLDSLEKELDEMDRNDAQAMEVRKQQRDKSNIDLKPK

Query:  ISRNAPKAPRNSKKTSNAETVPESMD-TTSSSTTTEVANNPVVKPKGKAAPRKAPAKKKQPQGKAAVL-DDEDDEVLELKDRLAAYKIESSPEPSEVSVM
        ISRNAPKAPRNSKKTSN+ET+ ESMD TTSSSTTTEVANNPVVKPKGKAAPRKAPAKK   QGKAAVL DD+DDEVLELKDRLAAYK+ESSPEPSEVS M
Subjt:  ISRNAPKAPRNSKKTSNAETVPESMD-TTSSSTTTEVANNPVVKPKGKAAPRKAPAKKKQPQGKAAVL-DDEDDEVLELKDRLAAYKIESSPEPSEVSVM

Query:  ETEVPQVQ-AAKKKEPSKRAAAKKKTTAKSAQISASDDDEDDFEIKEVAPPAAKKGGGRKAAANAKTTKPPAA------AAKLGQKLITQMLEPAENSGI
        ETEVP+VQ AAKKKEPSKRAAAKKKTTAKSAQIS  D D+ DFEIKE+APPAAKKGGGRKAAANAKTTK           A+LGQKLITQMLEP ENSGI
Subjt:  ETEVPQVQ-AAKKKEPSKRAAAKKKTTAKSAQISASDDDEDDFEIKEVAPPAAKKGGGRKAAANAKTTKPPAA------AAKLGQKLITQMLEPAENSGI

Query:  SPEKKVRKIRASPFNKKSGSILGRTIGEEE---EEAGNEDKVVGSASSETT-EEVARFPAARGRSQRANRTQVRYVVSDSDND-VSEASDFDEEASLDEE
        SPEKKVRKIR SPFNKKSGS+LGR IGEEE   EEAGNE K++GSASSETT EEVAR P ARGRSQR NRTQVRYVVSDSD++ V E SDFDEEA+LDE+
Subjt:  SPEKKVRKIRASPFNKKSGSILGRTIGEEE---EEAGNEDKVVGSASSETT-EEVARFPAARGRSQRANRTQVRYVVSDSDND-VSEASDFDEEASLDEE
XP_008461811.1 PREDICTED: DNA topoisomerase 2 [Cucumis melo]0.0e+0093.94Show/hide
Query:  MAVEKKRPLQNSNATNVDSNPAGPKKTIEEMYQKKSQLEHILLRPDTYVGSIEKHTQSLWVYENDKMVHRSISYVPGLYKIFDEILVNAADNKQRDPSMD
        M VEKKRPLQNSN  NVDSNPAGPKKTIEEMYQKKSQLEHILLRPDTYVGSIEKHTQ+LWVYENDKMVHRSISYVPGLYKIFDEILVNAADNKQRDPSMD
Subjt:  MAVEKKRPLQNSNATNVDSNPAGPKKTIEEMYQKKSQLEHILLRPDTYVGSIEKHTQSLWVYENDKMVHRSISYVPGLYKIFDEILVNAADNKQRDPSMD

Query:  SVKVNIDVEQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFNDNMGKKSE
        SVKVNIDVEQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADG+RLKKYKQVFNDNMGKKSE
Subjt:  SVKVNIDVEQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFNDNMGKKSE

Query:  PIITKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASTFQTEPPKRYHIKPNERWEIVV
        PIITKCKEGDNWT+VTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSAS+FQ EPPKRYHIKPNERWEIVV
Subjt:  PIITKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASTFQTEPPKRYHIKPNERWEIVV

Query:  TLSEGQFQQVSFVNGISTIKGGTHVDYITNQIANYVMTVVNKKNKNANVKAHNVKSYLWVFINALIDNPSFDSQTKETLTKRPNSFGSACELTPEFLKNV
        TLSEGQFQQVSFVNGI+TIKGGTHV+YITNQIANYVMT VNKKNKNANVKAHNVK+YLWVFINALIDNPSFDSQTKETLTKR NSFGSACELTPEFLKNV
Subjt:  TLSEGQFQQVSFVNGISTIKGGTHVDYITNQIANYVMTVVNKKNKNANVKAHNVKSYLWVFINALIDNPSFDSQTKETLTKRPNSFGSACELTPEFLKNV

Query:  ATKSGIMDSVLSWVNFKQSKDLKKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQIT
        ATKSGIMDSVLSWVNFKQSKDLKKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQIT
Subjt:  ATKSGIMDSVLSWVNFKQSKDLKKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQIT

Query:  ENKEIQYIKQILGLQQGKEYSNAKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLRVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWRESLR
        ENKEIQYIKQILGLQQGKEY+NAKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLRVPSFLVEFITPIVKATH+NGTVLSFYTMPEYESW+ESLR
Subjt:  ENKEIQYIKQILGLQQGKEYSNAKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLRVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWRESLR

Query:  GNASGWSIKYYKGLGTSTSKEGREYFEQLTKHKKDFIWQDDNDGEAIELAFSKKKIEDRKNWLRQFEPGTHLDQTGRLIKYSDFVNKELILFSMADLQRS
        GNASGWSIKYYKGLGTSTSKEGREYFEQLTKHKKDFIWQDDNDGEAIELAFSKKKIEDRKNWLRQFEPGTHLDQTG+LIKYSDFVNKELILFSMADLQRS
Subjt:  GNASGWSIKYYKGLGTSTSKEGREYFEQLTKHKKDFIWQDDNDGEAIELAFSKKKIEDRKNWLRQFEPGTHLDQTGRLIKYSDFVNKELILFSMADLQRS

Query:  IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT
        IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT
Subjt:  IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT

Query:  RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDIIRNVRRMLDGETMLPMDPWYRGFSGTIEKTATKEGGTSYTVS
        RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDIIRNVRRMLDGETMLPMDPWYRGFSGTIEKTATKEGGT+YT+S
Subjt:  RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDIIRNVRRMLDGETMLPMDPWYRGFSGTIEKTATKEGGTSYTVS

Query:  GIIEEVSDTTLRIIELPVRRWTNDYKDFLDSVTRVASKHDKDKEKAAKDPFIEQADHHSDDKIVSIDVHLTEENMLLAIQEGLKKKFKLTTTVSTSNMHL
        GIIEEVSDTTLRI+ELPVRRWT+DYKDFLDSVTRVASKH  DKEKAAKDPFIEQADHHSDDKIVSIDVHLTEENMLLAIQEGLKKKFKLTTTVSTSNMHL
Subjt:  GIIEEVSDTTLRIIELPVRRWTNDYKDFLDSVTRVASKHDKDKEKAAKDPFIEQADHHSDDKIVSIDVHLTEENMLLAIQEGLKKKFKLTTTVSTSNMHL

Query:  FDANGVIKKYDTPEQILEEFFPLRLEFYEKRKRNLLENLEMELLKLENKVRFILAVVNGEIIVSNRRKVDLFHELQAKGFTPFPKKTKSAEPEVAGASNE
        FDANGVIKKYDTPEQILEEFFPLRLEFYEKRKR LL+NLEMELLKLENKVRFILAVVN EI VSNR+KVDLFHELQAKGFTPFPKKTKS EPE+AGASNE
Subjt:  FDANGVIKKYDTPEQILEEFFPLRLEFYEKRKRNLLENLEMELLKLENKVRFILAVVNGEIIVSNRRKVDLFHELQAKGFTPFPKKTKSAEPEVAGASNE

Query:  TDEAEESPEVVKGERVSDYEYLLAMAIGTLTIEKVQELCNDRDKLKGEVDDLRKATPKSLWLNDLDSLEKELDEMDRNDAQAMEVRKQQRDKSNIDLKPK
        TDEAEESPEVVKGER+SDYEYLLA+ IGTLTIEKVQELCNDRDKLKGEVDDLRKATPKSLWLNDLDSLEKELDE+DRNDAQ ME+RKQQRDK+N DLKPK
Subjt:  TDEAEESPEVVKGERVSDYEYLLAMAIGTLTIEKVQELCNDRDKLKGEVDDLRKATPKSLWLNDLDSLEKELDEMDRNDAQAMEVRKQQRDKSNIDLKPK

Query:  ISRNAPKAPRNSKKTSNAETVPESMDTTSSSTTTEVANNPVVKPKGKAAPRKAPAKKKQPQGKAAVLD-DEDDEVLELKDRLAAYKIESSPEPSEVSVME
        ISRNAPKAPRNSKKTSN ETV ESMDTT SSTTTEVANNPVVKPKGKAAPRKAPAKKK   GKAAV D D+DDEVLELKDRLAAYKIESSPEPSEVS ME
Subjt:  ISRNAPKAPRNSKKTSNAETVPESMDTTSSSTTTEVANNPVVKPKGKAAPRKAPAKKKQPQGKAAVLD-DEDDEVLELKDRLAAYKIESSPEPSEVSVME

Query:  TEVPQVQAAKKKEPSKRAAAKKKTTAKSAQISASDD-DEDDFEIKEVAPPAAKKGGGR----KAAANAKTTKPPAAAAKLGQKLITQMLEPAENSGISPE
        TEV +VQAAKKKEPSKRA AKKKTTAKSAQIS SDD D+DDFEIKEV P AAKKGGGR     AAAN KTTK PAA  KLGQKLITQMLEPAENSGISPE
Subjt:  TEVPQVQAAKKKEPSKRAAAKKKTTAKSAQISASDD-DEDDFEIKEVAPPAAKKGGGR----KAAANAKTTKPPAAAAKLGQKLITQMLEPAENSGISPE

Query:  KKVRKIRASPFNKKSGSILGRTIGEEEEEAGNED--KVVGSASSETTEEVARFPAARGRSQRANRTQVRYVVSDSDND-VSEASDFDEEASLDEEASLDE
        KKVRKIRASPFNKKSGS+LGR I EEEEE G ED  KV+GSASSET+EEVA F  A GRS+RANRTQVRYV+SDSD++ VS+ SDFDE     +EASLDE
Subjt:  KKVRKIRASPFNKKSGSILGRTIGEEEEEAGNED--KVVGSASSETTEEVARFPAARGRSQRANRTQVRYVVSDSDND-VSEASDFDEEASLDEEASLDE

Query:  D
        D
Subjt:  D
XP_011651769.2 DNA topoisomerase 2 [Cucumis sativus]0.0e+0092.84Show/hide
Query:  MAVEKKRPLQNSNATNVDSNPAGPKKTIEEMYQKKSQLEHILLRPDTYVGSIEKHTQSLWVYENDKMVHRSISYVPGLYKIFDEILVNAADNKQRDPSMD
        M VEKKRPLQNSNA NVDSNPAGPKKTIEEMYQKKSQLEHILLRPDTYVGSIEKHTQ+LWVYEN+KMVHRSISYVPGLYKIFDEILVNAADNKQRDPSMD
Subjt:  MAVEKKRPLQNSNATNVDSNPAGPKKTIEEMYQKKSQLEHILLRPDTYVGSIEKHTQSLWVYENDKMVHRSISYVPGLYKIFDEILVNAADNKQRDPSMD

Query:  SVKVNIDVEQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFNDNMGKKSE
        SVKVNIDVEQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFS+EFVIETADG+RLKKYKQVFNDNMGKKSE
Subjt:  SVKVNIDVEQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFNDNMGKKSE

Query:  PIITKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASTFQTEPPKRYHIKPNERWEIVV
        PIITKCK GDNWT+VTFKPDL KFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPV+SFQDYVDLYLKSAS+ Q EPPKRYHI+PNERWEIVV
Subjt:  PIITKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASTFQTEPPKRYHIKPNERWEIVV

Query:  TLSEGQFQQVSFVNGISTIKGGTHVDYITNQIANYVMTVVNKKNKNANVKAHNVKSYLWVFINALIDNPSFDSQTKETLTKRPNSFGSACELTPEFLKNV
        TLSEGQFQQVSFVNGI+TIKGGTHV+YITNQIAN+VMT VNKKNKNANVKAHNVKSYLWVFINALIDNPSFDSQTKETLTKR NSFGSACELTP+FLKNV
Subjt:  TLSEGQFQQVSFVNGISTIKGGTHVDYITNQIANYVMTVVNKKNKNANVKAHNVKSYLWVFINALIDNPSFDSQTKETLTKRPNSFGSACELTPEFLKNV

Query:  ATKSGIMDSVLSWVNFKQSKDLKKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQIT
        ATKSGIMDSVLSWVNFKQSKDLKKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQIT
Subjt:  ATKSGIMDSVLSWVNFKQSKDLKKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQIT

Query:  ENKEIQYIKQILGLQQGKEYSNAKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLRVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWRESLR
        ENKEIQYIKQILGLQQGKEY+NA+ALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLRVPSFLVEFITPIVKATH+NGTVLSFYTMPEYE+W+ESLR
Subjt:  ENKEIQYIKQILGLQQGKEYSNAKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLRVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWRESLR

Query:  GNASGWSIKYYKGLGTSTSKEGREYFEQLTKHKKDFIWQDDNDGEAIELAFSKKKIEDRKNWLRQFEPGTHLDQTGRLIKYSDFVNKELILFSMADLQRS
        GNASGWSIKYYKGLGTSTSKEGREYFEQLTKHKKDFIWQDDNDGEAIELAFSKKKIEDRKNWLRQFEPGTHLDQTG+LIKYSDFVNKELILFSMADLQRS
Subjt:  GNASGWSIKYYKGLGTSTSKEGREYFEQLTKHKKDFIWQDDNDGEAIELAFSKKKIEDRKNWLRQFEPGTHLDQTGRLIKYSDFVNKELILFSMADLQRS

Query:  IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT
        IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT
Subjt:  IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT

Query:  RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDIIRNVRRMLDGETMLPMDPWYRGFSGTIEKTATKEGGTSYTVS
        RFLFP+DDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDIIRNVRRML+GETMLPMDPWYRGFSGTIEKTATKEGGT+YTVS
Subjt:  RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDIIRNVRRMLDGETMLPMDPWYRGFSGTIEKTATKEGGTSYTVS

Query:  GIIEEVSDTTLRIIELPVRRWTNDYKDFLDSVTRVASKHDKDKEKAAKDPFIEQADHHSDDKIVSIDVHLTEENMLLAIQEGLKKKFKLTTTVSTSNMHL
        GIIEEVSDTTLRI+ELPVRRWT+DYKDFLDSVTRVASKHDKDKEKAAKDPFIEQADHHSDDKIVSIDVHLTEENMLLAIQEGLKKKFKLTTTVSTSNMHL
Subjt:  GIIEEVSDTTLRIIELPVRRWTNDYKDFLDSVTRVASKHDKDKEKAAKDPFIEQADHHSDDKIVSIDVHLTEENMLLAIQEGLKKKFKLTTTVSTSNMHL

Query:  FDANGVIKKYDTPEQILEEFFPLRLEFYEKRKRNLLENLEMELLKLENKVRFILAVVNGEIIVSNRRKVDLFHELQAKGFTPFPKKTKSAEPEVAGASNE
        FDANGVIKKYDTPEQILEEFFPLRLEFYEKRKR LL+NLEMELLKLENKVRFILAVVN EI VSNR+KVDLFHELQAKGFTPFPKKTKS EPE+AGASNE
Subjt:  FDANGVIKKYDTPEQILEEFFPLRLEFYEKRKRNLLENLEMELLKLENKVRFILAVVNGEIIVSNRRKVDLFHELQAKGFTPFPKKTKSAEPEVAGASNE

Query:  TDEAEESPEVVKGERVSDYEYLLAMAIGTLTIEKVQELCNDRDKLKGEVDDLRKATPKSLWLNDLDSLEKELDEMDRNDAQAMEVRKQQRDKSNIDLKPK
        TDEAEESPEVVKGER+SDYEYLLA+ IGTLTIEKVQELC+DRDKLKGEVDDLRKATPKSLWLNDLD LEKELDEMDRNDAQ ME+RKQQR+K+NIDLKPK
Subjt:  TDEAEESPEVVKGERVSDYEYLLAMAIGTLTIEKVQELCNDRDKLKGEVDDLRKATPKSLWLNDLDSLEKELDEMDRNDAQAMEVRKQQRDKSNIDLKPK

Query:  ISRNAPKAPRNSKKTSNAETVPESMDTTSSSTTTEVANNPVVKPKGKAAPRKAPAKKKQPQGKAAVL----DDEDDEVLELKDRLAAYKIESSPEPSEVS
        +SRNAPKAPRNSKKTSN ETV ESMDTT SSTTTEVANNPVVKPKGKAAPRKAPAKKK   GKAAVL    DDEDDEVLELKDRLAAYKIESSPEPSEVS
Subjt:  ISRNAPKAPRNSKKTSNAETVPESMDTTSSSTTTEVANNPVVKPKGKAAPRKAPAKKKQPQGKAAVL----DDEDDEVLELKDRLAAYKIESSPEPSEVS

Query:  VMETEVPQV--QAAKKKEPSKRAAAKKKTTAKSAQISASDDDED-DFEIKEVAPPAAKKGGGR------KAAANAKTTKPPAAAAKLGQKLITQMLEP-A
         METEV +V  QAAKKKEPSKRA AKKKTTAKSAQIS SDDD D DFEIKEV PPAAKKGGGR       AA N+KTTKPPAA AKLGQKLITQMLEP A
Subjt:  VMETEVPQV--QAAKKKEPSKRAAAKKKTTAKSAQISASDDDED-DFEIKEVAPPAAKKGGGR------KAAANAKTTKPPAAAAKLGQKLITQMLEP-A

Query:  ENSGISPEKKVRKIRASPFNKKSGSILGRTIGEEEE-EAGNEDKVVGSASSETTEEVARFPAARGRSQRANR-TQVRYVVSDSDNDV-SEASDFDEEASL
        ENSGISPEKKVRKIRASPFNKKSGS+LGRTIGEEEE E  +E K++GSAS ET+EEV     ARGRS+RANR TQVRYV+SDSD +V S+ SDFDE    
Subjt:  ENSGISPEKKVRKIRASPFNKKSGSILGRTIGEEEE-EAGNEDKVVGSASSETTEEVARFPAARGRSQRANR-TQVRYVVSDSDNDV-SEASDFDEEASL

Query:  DEEASLDED
         +EASLDED
Subjt:  DEEASLDED
XP_038905935.1 DNA topoisomerase 2 [Benincasa hispida]0.0e+0093.26Show/hide
Query:  MAVEKKRPLQNSNATNVDSNP-AGPKKTIEEMYQKKSQLEHILLRPDTYVGSIEKHTQSLWVYENDKMVHRSISYVPGLYKIFDEILVNAADNKQRDPSM
        MAVEKKRPLQNSNA NVDS+P AGPKKTIEEMYQKKSQLEHILLRPDTYVGSIEKHTQ+LWVYENDKMVHRS+SYVPGLYKIFDEILVNAADNKQRDPSM
Subjt:  MAVEKKRPLQNSNATNVDSNP-AGPKKTIEEMYQKKSQLEHILLRPDTYVGSIEKHTQSLWVYENDKMVHRSISYVPGLYKIFDEILVNAADNKQRDPSM

Query:  DSVKVNIDVEQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFNDNMGKKS
        DSVKV+IDVEQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADGKR+KKYKQVFNDNMGKKS
Subjt:  DSVKVNIDVEQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFNDNMGKKS

Query:  EPIITKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASTFQTEPPKRYHIKPNERWEIV
        EPIITKCK GDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVP+KSFQDYVDLYLKSASTFQTEPPKRYHIKPN+RWEIV
Subjt:  EPIITKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASTFQTEPPKRYHIKPNERWEIV

Query:  VTLSEGQFQQVSFVNGISTIKGGTHVDYITNQIANYVMTVVNKKNKNANVKAHNVKSYLWVFINALIDNPSFDSQTKETLTKRPNSFGSACELTPEFLKN
        VTLSEGQFQQVSFVNGISTIKGGTHVDYITNQI+NYVMT VNKKNKNANVKAHNVK+YLWVFINALIDNPSFDSQTKETLTKR NSFGS CELTPEFLKN
Subjt:  VTLSEGQFQQVSFVNGISTIKGGTHVDYITNQIANYVMTVVNKKNKNANVKAHNVKSYLWVFINALIDNPSFDSQTKETLTKRPNSFGSACELTPEFLKN

Query:  VATKSGIMDSVLSWVNFKQSKDLKKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQI
        VATKSGIMDSVLSWVNFKQSKDLKKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREA+SKQI
Subjt:  VATKSGIMDSVLSWVNFKQSKDLKKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQI

Query:  TENKEIQYIKQILGLQQGKEYSNAKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLRVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWRESL
        TENKEIQYIKQILGLQQGKEY+NAKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLRVPSFLVEFITPIVKATH+NGTVLSFYTMPEYESW+ESL
Subjt:  TENKEIQYIKQILGLQQGKEYSNAKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLRVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWRESL

Query:  RGNASGWSIKYYKGLGTSTSKEGREYFEQLTKHKKDFIWQDDNDGEAIELAFSKKKIEDRKNWLRQFEPGTHLDQTGRLIKYSDFVNKELILFSMADLQR
        RGNASGWSIKYYKGLGTSTSKEGREYFEQLTKHKKDFIWQDDNDGEAIELAFSKKKIEDRKNWLRQFEPGTHLDQT +LIKYSDFVNKELILFSMADLQR
Subjt:  RGNASGWSIKYYKGLGTSTSKEGREYFEQLTKHKKDFIWQDDNDGEAIELAFSKKKIEDRKNWLRQFEPGTHLDQTGRLIKYSDFVNKELILFSMADLQR

Query:  SIPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLSNV
        SIPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRN GGKDHASSRYIYTKLSNV
Subjt:  SIPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLSNV

Query:  TRFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDIIRNVRRMLDGETMLPMDPWYRGFSGTIEKTATKEGGTSYTV
        TRFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDII+NVRRMLDG TMLPMDPWYRGFSGTIEKTATKEGGTSYTV
Subjt:  TRFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDIIRNVRRMLDGETMLPMDPWYRGFSGTIEKTATKEGGTSYTV

Query:  SGIIEEVSDTTLRIIELPVRRWTNDYKDFLDSVTRVASKHDKDKEKAAKDPFIEQADHHSDDKIVSIDVHLTEENMLLAIQEGLKKKFKLTTTVSTSNMH
        SGIIEEVSDT LRI+ELPVRRWTNDYKDFLDSVT+VA+KHDKDKEKAAK+PFIEQADHHSDDKIVSIDVHLTEENMLLAIQEGLKKKFKLTTTVSTSNMH
Subjt:  SGIIEEVSDTTLRIIELPVRRWTNDYKDFLDSVTRVASKHDKDKEKAAKDPFIEQADHHSDDKIVSIDVHLTEENMLLAIQEGLKKKFKLTTTVSTSNMH

Query:  LFDANGVIKKYDTPEQILEEFFPLRLEFYEKRKRNLLENLEMELLKLENKVRFILAVVNGEIIVSNRRKVDLFHELQAKGFTPFPKKTKSAEPEVAGASN
        LFDANGVIKKYDTPEQILEEFFPLRL+FYEKRKRNLLENLEMELLKLENKVRFIL VVN EIIV NRRKVDLFHELQAKGFTPFPKK KS EPEVAGAS+
Subjt:  LFDANGVIKKYDTPEQILEEFFPLRLEFYEKRKRNLLENLEMELLKLENKVRFILAVVNGEIIVSNRRKVDLFHELQAKGFTPFPKKTKSAEPEVAGASN

Query:  ETDEAEESPEVVKGERVSDYEYLLAMAIGTLTIEKVQELCNDRDKLKGEVDDLRKATPKSLWLNDLDSLEKELDEMDRNDAQAMEVRKQQRDKSNIDLKP
        E DEAEESPEVVK  RVSDYEYLL++ IGTLTIEKVQELCN+RDKLKGEVDDLRKATPK+LWLNDLDSLEKELDEMD NDAQAME RK+QRDK N DLKP
Subjt:  ETDEAEESPEVVKGERVSDYEYLLAMAIGTLTIEKVQELCNDRDKLKGEVDDLRKATPKSLWLNDLDSLEKELDEMDRNDAQAMEVRKQQRDKSNIDLKP

Query:  KISRNAPKAPRNSKKTSNAETVPESMDTTSSSTTTEVANNPVVKPKGKAAPRKAPAKKKQPQGKAAVLDDEDDEVLELKDRLAAYKIESSPEPSEVSVME
        KISRNAPKAPRN KKTSNAE V ESMDTT SSTT EVANNPVVKPKGKAAPRKAPAKK    GKAAVLDD+DDEVLELKDRLAAYKIESSPEPSEVS ME
Subjt:  KISRNAPKAPRNSKKTSNAETVPESMDTTSSSTTTEVANNPVVKPKGKAAPRKAPAKKKQPQGKAAVLDDEDDEVLELKDRLAAYKIESSPEPSEVSVME

Query:  TEVPQVQAAKKKEPSKRAAAKKKTTAKSAQISAS----DDDEDDFEIKEVAPPAAKKGGGR-----KAAANAKTTKPPAAAAKLGQKLITQMLEPAENSG
        TEVPQVQAAKKKEP+KRAAAKKKTTAKSAQ+S S    DDD+DDFE+KEVAPPA KKGGGR      AA NAKTTKPPAAAAKLGQKLIT+MLEPAENSG
Subjt:  TEVPQVQAAKKKEPSKRAAAKKKTTAKSAQISAS----DDDEDDFEIKEVAPPAAKKGGGR-----KAAANAKTTKPPAAAAKLGQKLITQMLEPAENSG

Query:  ISPEKKVRKIRASPFNKKSGSILGRTIG------EEEEEAGNEDKVVGSASSETT-EEVARFPAARGRSQRANRTQVRYVVSDSDND-VSEASDFDEE
        ISPEKKVRKIRASPFNKKSGSILGRTIG      EEEEE+G E+KV+GSASSETT EEVA    ARGRS RANRTQVRYVVSD D++ VSE SD DE+
Subjt:  ISPEKKVRKIRASPFNKKSGSILGRTIG------EEEEEAGNEDKVVGSASSETT-EEVARFPAARGRSQRANRTQVRYVVSDSDND-VSEASDFDEE
TrEMBL top hitse value%identityAlignment
A0A1S3CFK5 DNA topoisomerase 20.0e+0093.94Show/hide
Query:  MAVEKKRPLQNSNATNVDSNPAGPKKTIEEMYQKKSQLEHILLRPDTYVGSIEKHTQSLWVYENDKMVHRSISYVPGLYKIFDEILVNAADNKQRDPSMD
        M VEKKRPLQNSN  NVDSNPAGPKKTIEEMYQKKSQLEHILLRPDTYVGSIEKHTQ+LWVYENDKMVHRSISYVPGLYKIFDEILVNAADNKQRDPSMD
Subjt:  MAVEKKRPLQNSNATNVDSNPAGPKKTIEEMYQKKSQLEHILLRPDTYVGSIEKHTQSLWVYENDKMVHRSISYVPGLYKIFDEILVNAADNKQRDPSMD

Query:  SVKVNIDVEQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFNDNMGKKSE
        SVKVNIDVEQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADG+RLKKYKQVFNDNMGKKSE
Subjt:  SVKVNIDVEQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFNDNMGKKSE

Query:  PIITKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASTFQTEPPKRYHIKPNERWEIVV
        PIITKCKEGDNWT+VTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSAS+FQ EPPKRYHIKPNERWEIVV
Subjt:  PIITKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASTFQTEPPKRYHIKPNERWEIVV

Query:  TLSEGQFQQVSFVNGISTIKGGTHVDYITNQIANYVMTVVNKKNKNANVKAHNVKSYLWVFINALIDNPSFDSQTKETLTKRPNSFGSACELTPEFLKNV
        TLSEGQFQQVSFVNGI+TIKGGTHV+YITNQIANYVMT VNKKNKNANVKAHNVK+YLWVFINALIDNPSFDSQTKETLTKR NSFGSACELTPEFLKNV
Subjt:  TLSEGQFQQVSFVNGISTIKGGTHVDYITNQIANYVMTVVNKKNKNANVKAHNVKSYLWVFINALIDNPSFDSQTKETLTKRPNSFGSACELTPEFLKNV

Query:  ATKSGIMDSVLSWVNFKQSKDLKKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQIT
        ATKSGIMDSVLSWVNFKQSKDLKKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQIT
Subjt:  ATKSGIMDSVLSWVNFKQSKDLKKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQIT

Query:  ENKEIQYIKQILGLQQGKEYSNAKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLRVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWRESLR
        ENKEIQYIKQILGLQQGKEY+NAKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLRVPSFLVEFITPIVKATH+NGTVLSFYTMPEYESW+ESLR
Subjt:  ENKEIQYIKQILGLQQGKEYSNAKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLRVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWRESLR

Query:  GNASGWSIKYYKGLGTSTSKEGREYFEQLTKHKKDFIWQDDNDGEAIELAFSKKKIEDRKNWLRQFEPGTHLDQTGRLIKYSDFVNKELILFSMADLQRS
        GNASGWSIKYYKGLGTSTSKEGREYFEQLTKHKKDFIWQDDNDGEAIELAFSKKKIEDRKNWLRQFEPGTHLDQTG+LIKYSDFVNKELILFSMADLQRS
Subjt:  GNASGWSIKYYKGLGTSTSKEGREYFEQLTKHKKDFIWQDDNDGEAIELAFSKKKIEDRKNWLRQFEPGTHLDQTGRLIKYSDFVNKELILFSMADLQRS

Query:  IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT
        IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT
Subjt:  IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT

Query:  RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDIIRNVRRMLDGETMLPMDPWYRGFSGTIEKTATKEGGTSYTVS
        RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDIIRNVRRMLDGETMLPMDPWYRGFSGTIEKTATKEGGT+YT+S
Subjt:  RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDIIRNVRRMLDGETMLPMDPWYRGFSGTIEKTATKEGGTSYTVS

Query:  GIIEEVSDTTLRIIELPVRRWTNDYKDFLDSVTRVASKHDKDKEKAAKDPFIEQADHHSDDKIVSIDVHLTEENMLLAIQEGLKKKFKLTTTVSTSNMHL
        GIIEEVSDTTLRI+ELPVRRWT+DYKDFLDSVTRVASKH  DKEKAAKDPFIEQADHHSDDKIVSIDVHLTEENMLLAIQEGLKKKFKLTTTVSTSNMHL
Subjt:  GIIEEVSDTTLRIIELPVRRWTNDYKDFLDSVTRVASKHDKDKEKAAKDPFIEQADHHSDDKIVSIDVHLTEENMLLAIQEGLKKKFKLTTTVSTSNMHL

Query:  FDANGVIKKYDTPEQILEEFFPLRLEFYEKRKRNLLENLEMELLKLENKVRFILAVVNGEIIVSNRRKVDLFHELQAKGFTPFPKKTKSAEPEVAGASNE
        FDANGVIKKYDTPEQILEEFFPLRLEFYEKRKR LL+NLEMELLKLENKVRFILAVVN EI VSNR+KVDLFHELQAKGFTPFPKKTKS EPE+AGASNE
Subjt:  FDANGVIKKYDTPEQILEEFFPLRLEFYEKRKRNLLENLEMELLKLENKVRFILAVVNGEIIVSNRRKVDLFHELQAKGFTPFPKKTKSAEPEVAGASNE

Query:  TDEAEESPEVVKGERVSDYEYLLAMAIGTLTIEKVQELCNDRDKLKGEVDDLRKATPKSLWLNDLDSLEKELDEMDRNDAQAMEVRKQQRDKSNIDLKPK
        TDEAEESPEVVKGER+SDYEYLLA+ IGTLTIEKVQELCNDRDKLKGEVDDLRKATPKSLWLNDLDSLEKELDE+DRNDAQ ME+RKQQRDK+N DLKPK
Subjt:  TDEAEESPEVVKGERVSDYEYLLAMAIGTLTIEKVQELCNDRDKLKGEVDDLRKATPKSLWLNDLDSLEKELDEMDRNDAQAMEVRKQQRDKSNIDLKPK

Query:  ISRNAPKAPRNSKKTSNAETVPESMDTTSSSTTTEVANNPVVKPKGKAAPRKAPAKKKQPQGKAAVLD-DEDDEVLELKDRLAAYKIESSPEPSEVSVME
        ISRNAPKAPRNSKKTSN ETV ESMDTT SSTTTEVANNPVVKPKGKAAPRKAPAKKK   GKAAV D D+DDEVLELKDRLAAYKIESSPEPSEVS ME
Subjt:  ISRNAPKAPRNSKKTSNAETVPESMDTTSSSTTTEVANNPVVKPKGKAAPRKAPAKKKQPQGKAAVLD-DEDDEVLELKDRLAAYKIESSPEPSEVSVME

Query:  TEVPQVQAAKKKEPSKRAAAKKKTTAKSAQISASDD-DEDDFEIKEVAPPAAKKGGGR----KAAANAKTTKPPAAAAKLGQKLITQMLEPAENSGISPE
        TEV +VQAAKKKEPSKRA AKKKTTAKSAQIS SDD D+DDFEIKEV P AAKKGGGR     AAAN KTTK PAA  KLGQKLITQMLEPAENSGISPE
Subjt:  TEVPQVQAAKKKEPSKRAAAKKKTTAKSAQISASDD-DEDDFEIKEVAPPAAKKGGGR----KAAANAKTTKPPAAAAKLGQKLITQMLEPAENSGISPE

Query:  KKVRKIRASPFNKKSGSILGRTIGEEEEEAGNED--KVVGSASSETTEEVARFPAARGRSQRANRTQVRYVVSDSDND-VSEASDFDEEASLDEEASLDE
        KKVRKIRASPFNKKSGS+LGR I EEEEE G ED  KV+GSASSET+EEVA F  A GRS+RANRTQVRYV+SDSD++ VS+ SDFDE     +EASLDE
Subjt:  KKVRKIRASPFNKKSGSILGRTIGEEEEEAGNED--KVVGSASSETTEEVARFPAARGRSQRANRTQVRYVVSDSDND-VSEASDFDEEASLDEEASLDE

Query:  D
        D
Subjt:  D
A0A5A7TZH5 DNA topoisomerase 20.0e+0093.94Show/hide
Query:  MAVEKKRPLQNSNATNVDSNPAGPKKTIEEMYQKKSQLEHILLRPDTYVGSIEKHTQSLWVYENDKMVHRSISYVPGLYKIFDEILVNAADNKQRDPSMD
        M VEKKRPLQNSN  NVDSNPAGPKKTIEEMYQKKSQLEHILLRPDTYVGSIEKHTQ+LWVYENDKMVHRSISYVPGLYKIFDEILVNAADNKQRDPSMD
Subjt:  MAVEKKRPLQNSNATNVDSNPAGPKKTIEEMYQKKSQLEHILLRPDTYVGSIEKHTQSLWVYENDKMVHRSISYVPGLYKIFDEILVNAADNKQRDPSMD

Query:  SVKVNIDVEQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFNDNMGKKSE
        SVKVNIDVEQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADG+RLKKYKQVFNDNMGKKSE
Subjt:  SVKVNIDVEQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFNDNMGKKSE

Query:  PIITKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASTFQTEPPKRYHIKPNERWEIVV
        PIITKCKEGDNWT+VTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSAS+FQ EPPKRYHIKPNERWEIVV
Subjt:  PIITKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASTFQTEPPKRYHIKPNERWEIVV

Query:  TLSEGQFQQVSFVNGISTIKGGTHVDYITNQIANYVMTVVNKKNKNANVKAHNVKSYLWVFINALIDNPSFDSQTKETLTKRPNSFGSACELTPEFLKNV
        TLSEGQFQQVSFVNGI+TIKGGTHV+YITNQIANYVMT VNKKNKNANVKAHNVK+YLWVFINALIDNPSFDSQTKETLTKR NSFGSACELTPEFLKNV
Subjt:  TLSEGQFQQVSFVNGISTIKGGTHVDYITNQIANYVMTVVNKKNKNANVKAHNVKSYLWVFINALIDNPSFDSQTKETLTKRPNSFGSACELTPEFLKNV

Query:  ATKSGIMDSVLSWVNFKQSKDLKKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQIT
        ATKSGIMDSVLSWVNFKQSKDLKKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQIT
Subjt:  ATKSGIMDSVLSWVNFKQSKDLKKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQIT

Query:  ENKEIQYIKQILGLQQGKEYSNAKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLRVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWRESLR
        ENKEIQYIKQILGLQQGKEY+NAKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLRVPSFLVEFITPIVKATH+NGTVLSFYTMPEYESW+ESLR
Subjt:  ENKEIQYIKQILGLQQGKEYSNAKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLRVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWRESLR

Query:  GNASGWSIKYYKGLGTSTSKEGREYFEQLTKHKKDFIWQDDNDGEAIELAFSKKKIEDRKNWLRQFEPGTHLDQTGRLIKYSDFVNKELILFSMADLQRS
        GNASGWSIKYYKGLGTSTSKEGREYFEQLTKHKKDFIWQDDNDGEAIELAFSKKKIEDRKNWLRQFEPGTHLDQTG+LIKYSDFVNKELILFSMADLQRS
Subjt:  GNASGWSIKYYKGLGTSTSKEGREYFEQLTKHKKDFIWQDDNDGEAIELAFSKKKIEDRKNWLRQFEPGTHLDQTGRLIKYSDFVNKELILFSMADLQRS

Query:  IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT
        IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT
Subjt:  IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT

Query:  RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDIIRNVRRMLDGETMLPMDPWYRGFSGTIEKTATKEGGTSYTVS
        RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDIIRNVRRMLDGETMLPMDPWYRGFSGTIEKTATKEGGT+YT+S
Subjt:  RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDIIRNVRRMLDGETMLPMDPWYRGFSGTIEKTATKEGGTSYTVS

Query:  GIIEEVSDTTLRIIELPVRRWTNDYKDFLDSVTRVASKHDKDKEKAAKDPFIEQADHHSDDKIVSIDVHLTEENMLLAIQEGLKKKFKLTTTVSTSNMHL
        GIIEEVSDTTLRI+ELPVRRWT+DYKDFLDSVTRVASKH  DKEKAAKDPFIEQADHHSDDKIVSIDVHLTEENMLLAIQEGLKKKFKLTTTVSTSNMHL
Subjt:  GIIEEVSDTTLRIIELPVRRWTNDYKDFLDSVTRVASKHDKDKEKAAKDPFIEQADHHSDDKIVSIDVHLTEENMLLAIQEGLKKKFKLTTTVSTSNMHL

Query:  FDANGVIKKYDTPEQILEEFFPLRLEFYEKRKRNLLENLEMELLKLENKVRFILAVVNGEIIVSNRRKVDLFHELQAKGFTPFPKKTKSAEPEVAGASNE
        FDANGVIKKYDTPEQILEEFFPLRLEFYEKRKR LL+NLEMELLKLENKVRFILAVVN EI VSNR+KVDLFHELQAKGFTPFPKKTKS EPE+AGASNE
Subjt:  FDANGVIKKYDTPEQILEEFFPLRLEFYEKRKRNLLENLEMELLKLENKVRFILAVVNGEIIVSNRRKVDLFHELQAKGFTPFPKKTKSAEPEVAGASNE

Query:  TDEAEESPEVVKGERVSDYEYLLAMAIGTLTIEKVQELCNDRDKLKGEVDDLRKATPKSLWLNDLDSLEKELDEMDRNDAQAMEVRKQQRDKSNIDLKPK
        TDEAEESPEVVKGER+SDYEYLLA+ IGTLTIEKVQELCNDRDKLKGEVDDLRKATPKSLWLNDLDSLEKELDE+DRNDAQ ME+RKQQRDK+N DLKPK
Subjt:  TDEAEESPEVVKGERVSDYEYLLAMAIGTLTIEKVQELCNDRDKLKGEVDDLRKATPKSLWLNDLDSLEKELDEMDRNDAQAMEVRKQQRDKSNIDLKPK

Query:  ISRNAPKAPRNSKKTSNAETVPESMDTTSSSTTTEVANNPVVKPKGKAAPRKAPAKKKQPQGKAAVLD-DEDDEVLELKDRLAAYKIESSPEPSEVSVME
        ISRNAPKAPRNSKKTSN ETV ESMDTT SSTTTEVANNPVVKPKGKAAPRKAPAKKK   GKAAV D D+DDEVLELKDRLAAYKIESSPEPSEVS ME
Subjt:  ISRNAPKAPRNSKKTSNAETVPESMDTTSSSTTTEVANNPVVKPKGKAAPRKAPAKKKQPQGKAAVLD-DEDDEVLELKDRLAAYKIESSPEPSEVSVME

Query:  TEVPQVQAAKKKEPSKRAAAKKKTTAKSAQISASDD-DEDDFEIKEVAPPAAKKGGGR----KAAANAKTTKPPAAAAKLGQKLITQMLEPAENSGISPE
        TEV +VQAAKKKEPSKRA AKKKTTAKSAQIS SDD D+DDFEIKEV P AAKKGGGR     AAAN KTTK PAA  KLGQKLITQMLEPAENSGISPE
Subjt:  TEVPQVQAAKKKEPSKRAAAKKKTTAKSAQISASDD-DEDDFEIKEVAPPAAKKGGGR----KAAANAKTTKPPAAAAKLGQKLITQMLEPAENSGISPE

Query:  KKVRKIRASPFNKKSGSILGRTIGEEEEEAGNED--KVVGSASSETTEEVARFPAARGRSQRANRTQVRYVVSDSDND-VSEASDFDEEASLDEEASLDE
        KKVRKIRASPFNKKSGS+LGR I EEEEE G ED  KV+GSASSET+EEVA F  A GRS+RANRTQVRYV+SDSD++ VS+ SDFDE     +EASLDE
Subjt:  KKVRKIRASPFNKKSGSILGRTIGEEEEEAGNED--KVVGSASSETTEEVARFPAARGRSQRANRTQVRYVVSDSDND-VSEASDFDEEASLDEEASLDE

Query:  D
        D
Subjt:  D
A0A6J1F3D6 DNA topoisomerase 20.0e+0092.32Show/hide
Query:  MAVEKKRPLQNSNATNVDSNPAGPKKTIEEMYQKKSQLEHILLRPDTYVGSIEKHTQSLWVYENDKMVHRSISYVPGLYKIFDEILVNAADNKQRDPSMD
        MAVEKKRPLQNSNA NVDS+PAGPKKTIEEMYQKK+QLEHILLRPDTYVGSIEKHTQ+LWVYENDKMVHRS++YVPGLYKIFDEILVNAADNKQRDPSMD
Subjt:  MAVEKKRPLQNSNATNVDSNPAGPKKTIEEMYQKKSQLEHILLRPDTYVGSIEKHTQSLWVYENDKMVHRSISYVPGLYKIFDEILVNAADNKQRDPSMD

Query:  SVKVNIDVEQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFNDNMGKKSE
        S+KV ID EQN ISVFNNGDGVPVE+HQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADG+RLKKYKQVF+DNMGKKSE
Subjt:  SVKVNIDVEQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFNDNMGKKSE

Query:  PIITKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASTFQTEPPKRYHIKPNERWEIVV
        PIITKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVD YLKSA+ FQTEPPKRYHI+PNERWEIVV
Subjt:  PIITKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASTFQTEPPKRYHIKPNERWEIVV

Query:  TLSEGQFQQVSFVNGISTIKGGTHVDYITNQIANYVMTVVNKKNKNANVKAHNVKSYLWVFINALIDNPSFDSQTKETLTKRPNSFGSACELTPEFLKNV
        TLSEGQFQQVSFVNGI+TIKGGTHVDYITNQIANYVMTVVNKKNKNANVKAHNVKSYLWVFINALIDNP+FDSQTKETLT R +SFGSACELTP+FLKNV
Subjt:  TLSEGQFQQVSFVNGISTIKGGTHVDYITNQIANYVMTVVNKKNKNANVKAHNVKSYLWVFINALIDNPSFDSQTKETLTKRPNSFGSACELTPEFLKNV

Query:  ATKSGIMDSVLSWVNFKQSKDLKKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQIT
        ATKSGIMDSVLSWVNFKQSKDLKKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQIT
Subjt:  ATKSGIMDSVLSWVNFKQSKDLKKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQIT

Query:  ENKEIQYIKQILGLQQGKEYSNAKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLRVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWRESLR
        ENKEIQYIKQILGLQQGKEY+NAKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLRVPSFLVEFITPIVKATHRNGTVLSFYTMPEYE+W+++LR
Subjt:  ENKEIQYIKQILGLQQGKEYSNAKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLRVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWRESLR

Query:  GNASGWSIKYYKGLGTSTSKEGREYFEQLTKHKKDFIWQDDNDGEAIELAFSKKKIEDRKNWLRQFEPGTHLDQTGRLIKYSDFVNKELILFSMADLQRS
        GNASGWSIKYYKGLGTSTSKEGREYFEQL KHKKDFIWQD++DGEAIELAFSKKKIE+RKNWLRQFE GTHLDQ+ +LIKYSDFVNKELILFSMADLQRS
Subjt:  GNASGWSIKYYKGLGTSTSKEGREYFEQLTKHKKDFIWQDDNDGEAIELAFSKKKIEDRKNWLRQFEPGTHLDQTGRLIKYSDFVNKELILFSMADLQRS

Query:  IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT
        IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLSN T
Subjt:  IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT

Query:  RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDIIRNVRRMLDGETMLPMDPWYRGFSGTIEKTATKEGGTSYTVS
        RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSY+PNYNPRDIIRNVRRML+GE MLPMDPWYRGFSGTIEKTATKEGGTSYTVS
Subjt:  RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDIIRNVRRMLDGETMLPMDPWYRGFSGTIEKTATKEGGTSYTVS

Query:  GIIEEVSDTTLRIIELPVRRWTNDYKDFLDSVTRVASKHDKDKEKAAKDPFIEQADHHSDDKIVSIDVHLTEENMLLAIQEGLKKKFKLTTTVSTSNMHL
        GIIEEVSDTTLRI ELPVRRWTNDYKDFLDSVTRV++K+DKDKEKAAKDPFIEQADHHSDDK VSIDVHLTEENM+LA+QEGLKKKFKLTTTVSTSNMHL
Subjt:  GIIEEVSDTTLRIIELPVRRWTNDYKDFLDSVTRVASKHDKDKEKAAKDPFIEQADHHSDDKIVSIDVHLTEENMLLAIQEGLKKKFKLTTTVSTSNMHL

Query:  FDANGVIKKYDTPEQILEEFFPLRLEFYEKRKRNLLENLEMELLKLENKVRFILAVVNGEIIVSNRRKVDLFHELQAKGFTPFPKKTKSAEPEVAGASNE
        FDANGVIKKYDTPEQILEEFFPLRLEF+EKRKRNLLENLE ELLKLENKVRFILAVVNGEIIVSNRR+VDLFHELQ KGFTPFPKKTKS EPEVAGASNE
Subjt:  FDANGVIKKYDTPEQILEEFFPLRLEFYEKRKRNLLENLEMELLKLENKVRFILAVVNGEIIVSNRRKVDLFHELQAKGFTPFPKKTKSAEPEVAGASNE

Query:  TDEAEESPEVVKGERVSDYEYLLAMAIGTLTIEKVQELCNDRDKLKGEVDDLRKATPKSLWLNDLDSLEKELDEMDRNDAQAMEVRKQQRDKSNIDLKPK
        TDEAEESPEVVKGERVSDYEYLLA+AIGTLTIEKVQELCN+RDK KGEV++LRKATPKSLWL DLD LEKELDEMDRNDAQA EVRKQQR K+N D+KPK
Subjt:  TDEAEESPEVVKGERVSDYEYLLAMAIGTLTIEKVQELCNDRDKLKGEVDDLRKATPKSLWLNDLDSLEKELDEMDRNDAQAMEVRKQQRDKSNIDLKPK

Query:  ISRNAPKAPRNSKKTSNAETVPESMD-TTSSSTTTEVANNPVVKPKGKAAPRKAPAKKKQPQGKAAVL-DDEDDEVLELKDRLAAYKIESSPEPSEVSVM
        ISRNAPKAPRNSKKTSN+ET+ ESMD TTSSSTTTEVANNPVVKPKGKAAPRKAPAKK    GK AVL DD+DDEVLELKDRLAAYK+ESSPEPSEVS M
Subjt:  ISRNAPKAPRNSKKTSNAETVPESMD-TTSSSTTTEVANNPVVKPKGKAAPRKAPAKKKQPQGKAAVL-DDEDDEVLELKDRLAAYKIESSPEPSEVSVM

Query:  ETEVPQVQ-AAKKKEPSKRAAAKKKTTAKSAQISASDDDEDDFEIKEVAPPAAKKGGGRKAAANA---KTTKPPAAAAKLGQKLITQMLEPAENSGISPE
        ETEVP+VQ AAKKKEPSKRAAAKKKTTAKSAQIS  D D+ DFEIKE+APPAAKKGGGRKAAANA   KTTK     A+LGQKLITQMLEP ENSGISPE
Subjt:  ETEVPQVQ-AAKKKEPSKRAAAKKKTTAKSAQISASDDDEDDFEIKEVAPPAAKKGGGRKAAANA---KTTKPPAAAAKLGQKLITQMLEPAENSGISPE

Query:  KKVRKIRASPFNKKSGSILGRTIGEEE---EEAGNEDKVVGSASSETT-EEVARFPAARGRSQRANRTQVRYVVSDSDND-VSEASDFDEEASLDEE
        KKVRKIR SPFNKKSGS+LGR IGEEE   EEAGNE K++GSASSETT EEVAR P ARGRSQR NRTQVRYVVSDSD++ V E SDFDEEA+LDE+
Subjt:  KKVRKIRASPFNKKSGSILGRTIGEEE---EEAGNEDKVVGSASSETT-EEVARFPAARGRSQRANRTQVRYVVSDSDND-VSEASDFDEEASLDEE
A0A6J1F9E0 DNA topoisomerase 20.0e+0092.38Show/hide
Query:  MAVEKKRPLQNSNATNVDSNPAGPKKTIEEMYQKKSQLEHILLRPDTYVGSIEKHTQSLWVYENDKMVHRSISYVPGLYKIFDEILVNAADNKQRDPSMD
        MAVEKKRPLQNSNA NVDS+PAGPKKTIEEMYQKK+QLEHILLRPDTYVGSIEKHTQ+LWVYENDKMVHRS++YVPGLYKIFDEILVNAADNKQRDPSMD
Subjt:  MAVEKKRPLQNSNATNVDSNPAGPKKTIEEMYQKKSQLEHILLRPDTYVGSIEKHTQSLWVYENDKMVHRSISYVPGLYKIFDEILVNAADNKQRDPSMD

Query:  SVKVNIDVEQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFNDNMGKKSE
        S+KV ID EQN ISVFNNGDGVPVE+HQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADG+RLKKYKQVF+DNMGKKSE
Subjt:  SVKVNIDVEQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFNDNMGKKSE

Query:  PIITKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASTFQTEPPKRYHIKPNERWEIVV
        PIITKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVD YLKSA+ FQTEPPKRYHI+PNERWEIVV
Subjt:  PIITKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASTFQTEPPKRYHIKPNERWEIVV

Query:  TLSEGQFQQVSFVNGISTIKGGTHVDYITNQIANYVMTVVNKKNKNANVKAHNVKSYLWVFINALIDNPSFDSQTKETLTKRPNSFGSACELTPEFLKNV
        TLSEGQFQQVSFVNGI+TIKGGTHVDYITNQIANYVMTVVNKKNKNANVKAHNVKSYLWVFINALIDNP+FDSQTKETLT R +SFGSACELTP+FLKNV
Subjt:  TLSEGQFQQVSFVNGISTIKGGTHVDYITNQIANYVMTVVNKKNKNANVKAHNVKSYLWVFINALIDNPSFDSQTKETLTKRPNSFGSACELTPEFLKNV

Query:  ATKSGIMDSVLSWVNFKQSKDLKKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQIT
        ATKSGIMDSVLSWVNFKQSKDLKKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQIT
Subjt:  ATKSGIMDSVLSWVNFKQSKDLKKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQIT

Query:  ENKEIQYIKQILGLQQGKEYSNAKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLRVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWRESLR
        ENKEIQYIKQILGLQQGKEY+NAKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLRVPSFLVEFITPIVKATHRNGTVLSFYTMPEYE+W+++LR
Subjt:  ENKEIQYIKQILGLQQGKEYSNAKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLRVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWRESLR

Query:  GNASGWSIKYYKGLGTSTSKEGREYFEQLTKHKKDFIWQDDNDGEAIELAFSKKKIEDRKNWLRQFEPGTHLDQTGRLIKYSDFVNKELILFSMADLQRS
        GNASGWSIKYYKGLGTSTSKEGREYFEQL KHKKDFIWQD++DGEAIELAFSKKKIE+RKNWLRQFE GTHLDQ+ +LIKYSDFVNKELILFSMADLQRS
Subjt:  GNASGWSIKYYKGLGTSTSKEGREYFEQLTKHKKDFIWQDDNDGEAIELAFSKKKIEDRKNWLRQFEPGTHLDQTGRLIKYSDFVNKELILFSMADLQRS

Query:  IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT
        IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLSN T
Subjt:  IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT

Query:  RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDIIRNVRRMLDGETMLPMDPWYRGFSGTIEKTATKEGGTSYTVS
        RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSY+PNYNPRDIIRNVRRML+GE MLPMDPWYRGFSGTIEKTATKEGGTSYTVS
Subjt:  RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDIIRNVRRMLDGETMLPMDPWYRGFSGTIEKTATKEGGTSYTVS

Query:  GIIEEVSDTTLRIIELPVRRWTNDYKDFLDSVTRVASKHDKDKEKAAKDPFIEQADHHSDDKIVSIDVHLTEENMLLAIQEGLKKKFKLTTTVSTSNMHL
        GIIEEVSDTTLRI ELPVRRWTNDYKDFLDSVTRV++K+DKDKEKAAKDPFIEQADHHSDDK VSIDVHLTEENM+LA+QEGLKKKFKLTTTVSTSNMHL
Subjt:  GIIEEVSDTTLRIIELPVRRWTNDYKDFLDSVTRVASKHDKDKEKAAKDPFIEQADHHSDDKIVSIDVHLTEENMLLAIQEGLKKKFKLTTTVSTSNMHL

Query:  FDANGVIKKYDTPEQILEEFFPLRLEFYEKRKRNLLENLEMELLKLENKVRFILAVVNGEIIVSNRRKVDLFHELQAKGFTPFPKKTKSAEPEVAGASNE
        FDANGVIKKYDTPEQILEEFFPLRLEF+EKRKRNLLENLE ELLKLENKVRFILAVVNGEIIVSNRR+VDLFHELQ KGFTPFPKKTKS EPEVAGASNE
Subjt:  FDANGVIKKYDTPEQILEEFFPLRLEFYEKRKRNLLENLEMELLKLENKVRFILAVVNGEIIVSNRRKVDLFHELQAKGFTPFPKKTKSAEPEVAGASNE

Query:  TDEAEESPEVVKGERVSDYEYLLAMAIGTLTIEKVQELCNDRDKLKGEVDDLRKATPKSLWLNDLDSLEKELDEMDRNDAQAMEVRKQQRDKSNIDLKPK
        TDEAEESPEVVKGERVSDYEYLLA+AIGTLTIEKVQELCN+RDK KGEV++LRKATPKSLWL DLD LEKELDEMDRNDAQA EVRKQQR K+N D+KPK
Subjt:  TDEAEESPEVVKGERVSDYEYLLAMAIGTLTIEKVQELCNDRDKLKGEVDDLRKATPKSLWLNDLDSLEKELDEMDRNDAQAMEVRKQQRDKSNIDLKPK

Query:  ISRNAPKAPRNSKKTSNAETVPESMD-TTSSSTTTEVANNPVVKPKGKAAPRKAPAKKKQPQGKAAVL-DDEDDEVLELKDRLAAYKIESSPEPSEVSVM
        ISRNAPKAPRNSKKTSN+ET+ ESMD TTSSSTTTEVANNPVVKPKGKAAPRKAPAKK   QGK AVL DD+DDEVLELKDRLAAYK+ESSPEPSEVS M
Subjt:  ISRNAPKAPRNSKKTSNAETVPESMD-TTSSSTTTEVANNPVVKPKGKAAPRKAPAKKKQPQGKAAVL-DDEDDEVLELKDRLAAYKIESSPEPSEVSVM

Query:  ETEVPQVQ-AAKKKEPSKRAAAKKKTTAKSAQISASDDDEDDFEIKEVAPPAAKKGGGRKAAANA---KTTKPPAAAAKLGQKLITQMLEPAENSGISPE
        ETEVP+VQ AAKKKEPSKRAAAKKKTTAKSAQIS  D D+ DFEIKE+APPAAKKGGGRKAAANA   KTTK     A+LGQKLITQMLEP ENSGISPE
Subjt:  ETEVPQVQ-AAKKKEPSKRAAAKKKTTAKSAQISASDDDEDDFEIKEVAPPAAKKGGGRKAAANA---KTTKPPAAAAKLGQKLITQMLEPAENSGISPE

Query:  KKVRKIRASPFNKKSGSILGRTIGEEE---EEAGNEDKVVGSASSETT-EEVARFPAARGRSQRANRTQVRYVVSDSDND-VSEASDFDEEASLDEE
        KKVRKIR SPFNKKSGS+LGR IGEEE   EEAGNE K++GSASSETT EEVAR P ARGRSQR NRTQVRYVVSDSD++ V E SDFDEEA+LDE+
Subjt:  KKVRKIRASPFNKKSGSILGRTIGEEE---EEAGNEDKVVGSASSETT-EEVARFPAARGRSQRANRTQVRYVVSDSDND-VSEASDFDEEASLDEE
A0A6J1IWX9 DNA topoisomerase 20.0e+0092.32Show/hide
Query:  MAVEKKRPLQNSNATNVDSNPAGPKKTIEEMYQKKSQLEHILLRPDTYVGSIEKHTQSLWVYENDKMVHRSISYVPGLYKIFDEILVNAADNKQRDPSMD
        MAVE KRPLQNSNA NVDS+PAGPKKTIEEMYQKK+QLEHILLRPDTYVGSIEKHTQ+LW+YENDKMVHRS++YVPGLYKIFDEILVNAADNKQRDPSMD
Subjt:  MAVEKKRPLQNSNATNVDSNPAGPKKTIEEMYQKKSQLEHILLRPDTYVGSIEKHTQSLWVYENDKMVHRSISYVPGLYKIFDEILVNAADNKQRDPSMD

Query:  SVKVNIDVEQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFNDNMGKKSE
        S+KV ID EQNCISVFNNGDGVPVE+HQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADG+RLKKYKQVF+DNMGKKSE
Subjt:  SVKVNIDVEQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFNDNMGKKSE

Query:  PIITKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASTFQTEPPKRYHIKPNERWEIVV
        PIITKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVD YLKSA+ FQTEPPKRYHI+PNERWEIVV
Subjt:  PIITKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASTFQTEPPKRYHIKPNERWEIVV

Query:  TLSEGQFQQVSFVNGISTIKGGTHVDYITNQIANYVMTVVNKKNKNANVKAHNVKSYLWVFINALIDNPSFDSQTKETLTKRPNSFGSACELTPEFLKNV
        TLSEGQFQQVSFVNGI+TIKGGTHVDYITNQIANYVMTVVNKKNKNANVKAHNVKSYLWVFINALIDNP+FDSQTKETLT R +SFGSACELTP+FLKNV
Subjt:  TLSEGQFQQVSFVNGISTIKGGTHVDYITNQIANYVMTVVNKKNKNANVKAHNVKSYLWVFINALIDNPSFDSQTKETLTKRPNSFGSACELTPEFLKNV

Query:  ATKSGIMDSVLSWVNFKQSKDLKKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQIT
        ATKSGIMDSVLSWVNFKQSKDLKKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQIT
Subjt:  ATKSGIMDSVLSWVNFKQSKDLKKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQIT

Query:  ENKEIQYIKQILGLQQGKEYSNAKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLRVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWRESLR
        ENKEIQYIKQILGLQQGKEY+NAKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLRVPSFLVEFITPIVKATHRNGTVLSFYTMPEYE+W+++LR
Subjt:  ENKEIQYIKQILGLQQGKEYSNAKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLRVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWRESLR

Query:  GNASGWSIKYYKGLGTSTSKEGREYFEQLTKHKKDFIWQDDNDGEAIELAFSKKKIEDRKNWLRQFEPGTHLDQTGRLIKYSDFVNKELILFSMADLQRS
        GNASGWSIKYYKGLGTSTSKEGREYFEQL KHKKDFIWQD++DGEAIELAFSKKKIE+RKNWLRQFE GTHLDQ+ +LIKYSDFVNKELILFSMADLQRS
Subjt:  GNASGWSIKYYKGLGTSTSKEGREYFEQLTKHKKDFIWQDDNDGEAIELAFSKKKIEDRKNWLRQFEPGTHLDQTGRLIKYSDFVNKELILFSMADLQRS

Query:  IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT
        IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLSN T
Subjt:  IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT

Query:  RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDIIRNVRRMLDGETMLPMDPWYRGFSGTIEKTATKEGGTSYTVS
        RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSY+PNYNPRDIIRNVRRMLDGE MLPMDPWYRGFSGTIEKTATKEGGTSYTVS
Subjt:  RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDIIRNVRRMLDGETMLPMDPWYRGFSGTIEKTATKEGGTSYTVS

Query:  GIIEEVSDTTLRIIELPVRRWTNDYKDFLDSVTRVASKHDKDKEKAAKDPFIEQADHHSDDKIVSIDVHLTEENMLLAIQEGLKKKFKLTTTVSTSNMHL
        GIIEEVSDTTLRI ELPVRRWTNDYKDFLDSVTRV++K+DKDKEKAAKDPFIEQADHHSDDK VSI+VHLTEENM+LA+QEGLKKKFKLTTTVSTSNMHL
Subjt:  GIIEEVSDTTLRIIELPVRRWTNDYKDFLDSVTRVASKHDKDKEKAAKDPFIEQADHHSDDKIVSIDVHLTEENMLLAIQEGLKKKFKLTTTVSTSNMHL

Query:  FDANGVIKKYDTPEQILEEFFPLRLEFYEKRKRNLLENLEMELLKLENKVRFILAVVNGEIIVSNRRKVDLFHELQAKGFTPFPKKTKSAEPEVAGASNE
        FDANGVIKKYDTPEQILEEFFPLRLEF+EKRKRNLLENLE ELLKLENKVRFILAVVNGEIIVSNRR+VDLFHELQ KGFTPFPKKTKS EPEVAGASNE
Subjt:  FDANGVIKKYDTPEQILEEFFPLRLEFYEKRKRNLLENLEMELLKLENKVRFILAVVNGEIIVSNRRKVDLFHELQAKGFTPFPKKTKSAEPEVAGASNE

Query:  TDEAEESPEVVKGERVSDYEYLLAMAIGTLTIEKVQELCNDRDKLKGEVDDLRKATPKSLWLNDLDSLEKELDEMDRNDAQAMEVRKQQRDKSNIDLKPK
        TDEAEESPEVVKGERVSDYEYLLA+AIGTLTIEKVQELCN+RDK KGEV++LRKATPKSLWL DLD LEKELDEMDRNDAQA EVRKQQR K+N D+KPK
Subjt:  TDEAEESPEVVKGERVSDYEYLLAMAIGTLTIEKVQELCNDRDKLKGEVDDLRKATPKSLWLNDLDSLEKELDEMDRNDAQAMEVRKQQRDKSNIDLKPK

Query:  ISRNAPKAPRNSKKTSNAETVPESMD-TTSSSTTTEVANNPVVKPKGKAAPRKAPAKKKQPQGKAAVLDDE-DDEVLELKDRLAAYKIESSPEPSEVSVM
        ISRNAPKAPRNSKKTSN+ET+ ESMD  TSSSTTTEVANNPVVKPKGKAAPRKAPAKK   QGKAAVLDD+ DDEVLELKDRLAAYK+ESSPEPSEVS M
Subjt:  ISRNAPKAPRNSKKTSNAETVPESMD-TTSSSTTTEVANNPVVKPKGKAAPRKAPAKKKQPQGKAAVLDDE-DDEVLELKDRLAAYKIESSPEPSEVSVM

Query:  ETEVPQVQ-AAKKKEPSKRAAAKKKTTAKSAQISASDDDEDDFEIKEVAPPAAKKGGGRKAAANA---KTTKPPAAAAKLGQKLITQMLEPAENSGISPE
        ETEVP+VQ AAKKKEPSKRAAAKKKTTAKSAQIS  D D+ DFEIKE+APPAAKKGGGRKAAANA   KTTK     A+LGQKLITQMLEP ENSGISPE
Subjt:  ETEVPQVQ-AAKKKEPSKRAAAKKKTTAKSAQISASDDDEDDFEIKEVAPPAAKKGGGRKAAANA---KTTKPPAAAAKLGQKLITQMLEPAENSGISPE

Query:  KKVRKIRASPFNKKSGSILGRTIGEEE---EEAGNEDKVVGSASSETT-EEVARFPAARGRSQRANRTQVRYVVSDSDND-VSEASDFDEEASLDEE
        KKVRKIR SPFNKKSGS+LGR IGEEE   EEAGNE K++GSASSETT EEVAR P ARGRSQR NRTQVRYVVSDSD++ V E SDFDEEA LDE+
Subjt:  KKVRKIRASPFNKKSGSILGRTIGEEE---EEAGNEDKVVGSASSETT-EEVARFPAARGRSQRANRTQVRYVVSDSDND-VSEASDFDEEASLDEE
SwissProt top hitse value%identityAlignment
O24308 DNA topoisomerase 20.0e+0062.82Show/hide
Query:  KKRPLQNSNATNVDSNPAGPKKTIEEMYQKKSQLEHILLRPDTYVGSIEKHTQSLWVYENDKMVHRSISYVPGLYKIFDEILVNAADNKQRDPSMDSVKV
        +KRPLQ SNA N+      P KTIEEMYQKK+QLEHILLRPDTYVGSIEKHTQ+LWVYEND+MVHR++SYVPGLYKIFDEILVNAADNKQRDPSMDS+KV
Subjt:  KKRPLQNSNATNVDSNPAGPKKTIEEMYQKKSQLEHILLRPDTYVGSIEKHTQSLWVYENDKMVHRSISYVPGLYKIFDEILVNAADNKQRDPSMDSVKV

Query:  NIDVEQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFNDNMGKKSEPIIT
         ID E N +SV+NNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDD  KKTTGGRNGYGAKLTNIFSTEF+IETADG+RLKKYKQVF++NMG K EP+IT
Subjt:  NIDVEQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFNDNMGKKSEPIIT

Query:  KCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASTFQTEPPKRYHIKPNERWEIVVTLSE
        KCK  +NWTKVTFKPDL KF M +LE+DVVALMKKRVLD+AGC GKTVKVELNG  +  KSF+DY DL+LK A   +  P  R H K  +RWEI ++LS+
Subjt:  KCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASTFQTEPPKRYHIKPNERWEIVVTLSE

Query:  GQFQQVSFVNGISTIKGGTHVDYITNQIANYVMTVVNKKNKNANVKAHNVKSYLWVFINALIDNPSFDSQTKETLTKRPNSFGSACELTPEFLKNVATKS
        GQFQQVSFVN I+TIKGGTHVDYITNQI  Y+M  VNKK K+ANVKAH VK++LWVF+N+LIDNP+FDSQTKETLT R  SFGS C++    LK+V  KS
Subjt:  GQFQQVSFVNGISTIKGGTHVDYITNQIANYVMTVVNKKNKNANVKAHNVKSYLWVFINALIDNPSFDSQTKETLTKRPNSFGSACELTPEFLKNVATKS

Query:  GIMDSVLSWVNFKQSKDLKKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQITENKE
        GI+D++LSW +FKQSKDLKKTDG KT+++ G  K EDAN AGG+NSEKCTLILTEGDSAKALAMAGL VVGRD YGVFPLRGKLLNVREASSKQI +N+E
Subjt:  GIMDSVLSWVNFKQSKDLKKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQITENKE

Query:  IQYIKQILGLQQGKEYSNAKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLRVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWRESLRGNAS
        IQ IK+ILGLQQ KEY+N K+LRYGHLMIM DQDHDGSHIKGLLINFIHSFWPSLL+VPSFLVEF TP+++A+H N T+ SFY+MPEYE+W+E L  +A+
Subjt:  IQYIKQILGLQQGKEYSNAKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLRVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWRESLRGNAS

Query:  GWSIKYYKGLGTSTSKEGREYFEQLTKHKKDFIWQDDNDGEAIELAFSKKKIEDRKNWLRQFEPGTHLDQTGRLIKYSDFVNKELILFSMADLQRSIPSM
         W IKYYKGLGTST +EGREYF  L +H+KDFIW D+ DG AIELAFSKKK E RK W+R FEPGT  D   +LI Y DFVNKELILFS AD        
Subjt:  GWSIKYYKGLGTSTSKEGREYFEQLTKHKKDFIWQDDNDGEAIELAFSKKKIEDRKNWLRQFEPGTHLDQTGRLIKYSDFVNKELILFSMADLQRSIPSM

Query:  VDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVTRFLF
                   LF SFK+   KE KV+QF GYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLL PNGQFGT N GGKDHAS+RYIYT+LS VTR LF
Subjt:  VDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVTRFLF

Query:  PKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDIIRNVRRMLDGETMLPMDPWYRGFSGTIEKTATKEGGTSYTVSGIIE
         + DDKLL YLNEDG+SIEP WYMPIIP VLVNGSEGIGTGWSSY+PNYNPR+II NVRR+L+GE ++PMDPWY+GF GTIEK+A KEGG  Y V+G + 
Subjt:  PKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDIIRNVRRMLDGETMLPMDPWYRGFSGTIEKTATKEGGTSYTVSGIIE

Query:  EVSDTTLRIIELPVRRWTNDYKDFLDSVTRVASKHDKDKEKAAKDPFIEQADHHSDDKIVSIDVHLTEENMLLAIQEGLKKKFKLTTTVSTSNMHLFDAN
        E+ + T RI ELP+R+WT DYK FL+S+T        D     KDP IE    + DD IV I++ +  E +   +QEGL KKFKLT+T+STSNMHLFDA 
Subjt:  EVSDTTLRIIELPVRRWTNDYKDFLDSVTRVASKHDKDKEKAAKDPFIEQADHHSDDKIVSIDVHLTEENMLLAIQEGLKKKFKLTTTVSTSNMHLFDAN

Query:  GVIKKYDTPEQILEEFFPLRLEFYEKRKRNLLENLEMELLKLENKVRFILAVVNGEIIVSNRRKVDLFHELQAKGFTPFPKKTKSAEPEVAGASNETDEA
        G  KK+DTPEQILEEFFPLRL++YEK K  +L NL   LL L+NKVRFIL VVNGEIIVSNR+K +L  EL+ KGFTP P+K KS +P+VAGA+++  E 
Subjt:  GVIKKYDTPEQILEEFFPLRLEFYEKRKRNLLENLEMELLKLENKVRFILAVVNGEIIVSNRRKVDLFHELQAKGFTPFPKKTKSAEPEVAGASNETDEA

Query:  EESPE--------VVKGERVSDYEYLLAMAIGTLTIEKVQELCNDRDKLKGEVDDLRKATPKSLWLNDLDSLEKELDEMDRNDAQAMEVRKQQRDKSNID
        +E  E         V+G    DY+ LL++ IGTLT+E VQ+L +++ + + E + L      SLWL DLD  EK+LDE+D   A+    R  Q  K    
Subjt:  EESPE--------VVKGERVSDYEYLLAMAIGTLTIEKVQELCNDRDKLKGEVDDLRKATPKSLWLNDLDSLEKELDEMDRNDAQAMEVRKQQRDKSNID

Query:  LKPKISRNAPKAPRNSKKTSNAETVPESMDTTSSSTTTEVANNP--VVKPKGKAAPRKAPAKKKQPQGKAAVLDDEDDEVLELKDRLAAYKIESSPEPSE
           K ++  P+  +N+KK  + E  PE+ +++        A  P  V KPKG+AAP+K   K            + +D++  L++RLAAY IESS E S+
Subjt:  LKPKISRNAPKAPRNSKKTSNAETVPESMDTTSSSTTTEVANNP--VVKPKGKAAPRKAPAKKKQPQGKAAVLDDEDDEVLELKDRLAAYKIESSPEPSE

Query:  VSVMETEVPQVQAAKKKEPSKRAAAKKKTTA------KSAQISASDDDEDDFEIKEVAPPAAKKGGGRKAAANAK------TTKPPAAAAK--------L
           ME+E  Q +AA KK+ +KR  AKKK++          +++  DDD+DDFE  +      KKGG + AA NAK        K PAA  K         
Subjt:  VSVMETEVPQVQAAKKKEPSKRAAAKKKTTA------KSAQISASDDDEDDFEIKEVAPPAAKKGGGRKAAANAK------TTKPPAAAAK--------L

Query:  GQKLITQMLEPAENSGISPEKKVRKIRASPFNKKSGSILGRTIGEEEEEAGNEDKVVGSASS-----ETTEEVARFPAARGRSQRANRTQVRYVVSDSDN
        GQKL+T ML+PAE +G SPEKKVRK+R SPFNKKSGSILGR     ++ +   D   GSAS+     +   E+A  P AR R QRANRTQ++Y +S+S++
Subjt:  GQKLITQMLEPAENSGISPEKKVRKIRASPFNKKSGSILGRTIGEEEEEAGNEDKVVGSASS-----ETTEEVARFPAARGRSQRANRTQVRYVVSDSDN

Query:  DVSEASDFDEEASLDEE
        +  E SD D E S  EE
Subjt:  DVSEASDFDEEASLDEE
O42130 DNA topoisomerase 2-alpha0.0e+0046.27Show/hide
Query:  RPLQNSNATNVDSNPAGPKKTIEEMYQKKSQLEHILLRPDTYVGSIEKHTQSLWVYENDKMVH-RSISYVPGLYKIFDEILVNAADNKQRDPSMDSVKVN
        RPL + N     ++ A  + ++E +YQKK+QLEHILLRPDTY+GS+E  TQ +WV++ D  ++ R +++VPGLYKIFDEILVNAADNKQRD SM  +KV 
Subjt:  RPLQNSNATNVDSNPAGPKKTIEEMYQKKSQLEHILLRPDTYVGSIEKHTQSLWVYENDKMVH-RSISYVPGLYKIFDEILVNAADNKQRDPSMDSVKVN

Query:  IDVEQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFNDNMGKKSEPIITK
        ID E N ISV+NNG G+PV  H+ EKVYVP LIFG LLTSSNYDD EKK TGGRNGYGAKL NIFST+F +ETA  +  K +KQ + DNMGK  E +  K
Subjt:  IDVEQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFNDNMGKKSEPIITK

Query:  CKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASTFQTEPPKRYHIKPNERWEIVVTLSEG
          +G+++T VTF+PDL+KF MT L+ D+VALM +R  D+AG   K VKV LNG+R+PVK F+ YVDLYLK          K  H + N RWE+ +TLSE 
Subjt:  CKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASTFQTEPPKRYHIKPNERWEIVVTLSEG

Query:  QFQQVSFVNGISTIKGGTHVDYITNQIANYVMTVVNKKNKN-ANVKAHNVKSYLWVFINALIDNPSFDSQTKETLTKRPNSFGSACELTPEFLKNVATKS
         FQQVSFVN I+T KGG HVDY+ +QI   ++ VV KKNKN   VK   VK+++W+F+N+LI+NP+FDSQTKE +T +  SFGS C+L+ +F+K  A   
Subjt:  QFQQVSFVNGISTIKGGTHVDYITNQIANYVMTVVNKKNKN-ANVKAHNVKSYLWVFINALIDNPSFDSQTKETLTKRPNSFGSACELTPEFLKNVATKS

Query:  GIMDSVLSWVNFKQSKDL-KKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQITENK
        GI++S+L+WV FK    L KK    K  KI G+ KL+DAN AG KNS  CTLILTEGDSAK LA++GLGVVGRD YGVFPLRGK+LNVREAS KQI EN 
Subjt:  GIMDSVLSWVNFKQSKDL-KKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQITENK

Query:  EIQYIKQILGLQQGKEY---SNAKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLRVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWRESLR
        EI  I +I+GLQ  K Y    + K+LRYG +MIMTDQD DGSHIKGLLINFIH  WPSLLR  +FL EFITPI+K + +N   + FY++PE+E W+ S +
Subjt:  EIQYIKQILGLQQGKEY---SNAKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLRVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWRESLR

Query:  GNASGWSIKYYKGLGTSTSKEGREYFEQLTKHKKDFIWQDDNDGEAIELAFSKKKIEDRKNWLRQFE-----------PGTHL-DQTGRLIKYSDFVNKE
         N + W IKYYKGLGTSTSKE +EYF  + +H+  F +    D  AI LAFSKKK+E+RK WL  F            P  +L  +    + Y+DF+NKE
Subjt:  GNASGWSIKYYKGLGTSTSKEGREYFEQLTKHKKDFIWQDDNDGEAIELAFSKKKIEDRKNWLRQFE-----------PGTHL-DQTGRLIKYSDFVNKE

Query:  LILFSMADLQRSIPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHAS
        L+LFS +D +RSIPS+VDGLKPGQRK+LF  FKRN  +E K +Q +G V+E S+YHHGE SL  TII +AQ+FVGSNN+NLL P GQFGTR HGGKD AS
Subjt:  LILFSMADLQRSIPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHAS

Query:  SRYIYTKLSNVTRFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDIIRNVRRMLDGETMLPMDPWYRGFSGTIEKT
         RYI+T LS + R LFP  DD +L +L +D Q +EP WYMPIIP VL+NG+EGIGTGWS  +PN++ R+ + N+R +LDG+  LPM P Y+ F GTI++ 
Subjt:  SRYIYTKLSNVTRFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDIIRNVRRMLDGETMLPMDPWYRGFSGTIEKT

Query:  ATKEGGTSYTVSGIIEEVSDTTLRIIELPVRRWTNDYKDFLDSVTRVASKHDKDKEKAAKDPFIEQADHHSDDKIVSIDVHLTEENMLLAIQEGLKKKFK
            G   Y +SG +  +  TT+ I ELPVR WT  YK+      +V        EK    P I     +  D  V   V ++EE +  A   GL K FK
Subjt:  ATKEGGTSYTVSGIIEEVSDTTLRIIELPVRRWTNDYKDFLDSVTRVASKHDKDKEKAAKDPFIEQADHHSDDKIVSIDVHLTEENMLLAIQEGLKKKFK

Query:  LTTTVSTSNMHLFDANGVIKKYDTPEQILEEFFPLRLEFYEKRKRNLLENLEMELLKLENKVRFILAVVNGEIIVSNRRKVDLFHELQAKGFTPFPKKTK
        L T ++ ++M LFD  G +KKY++P+ IL+EFF LRL +Y  RK  L+  L  E  KL N+ RFIL  ++G+I++ N+ K +L   L  +G+   P K  
Subjt:  LTTTVSTSNMHLFDANGVIKKYDTPEQILEEFFPLRLEFYEKRKRNLLENLEMELLKLENKVRFILAVVNGEIIVSNRRKVDLFHELQAKGFTPFPKKTK

Query:  SAEPEVAGASNETDEAEESPEVVKGERVSDYEYLLAMAIGTLTIEKVQELCNDRDKLKGEVDDLRKATPKSLWLNDLDSLEKELDEMDRNDAQAMEVRKQ
         A  E+   + E +E +ES E        D+ YLL M +  LT EK  ELC  RD    E++DL+  +P  LW  DL +  +ELD        A+E ++ 
Subjt:  SAEPEVAGASNETDEAEESPEVVKGERVSDYEYLLAMAIGTLTIEKVQELCNDRDKLKGEVDDLRKATPKSLWLNDLDSLEKELDEMDRNDAQAMEVRKQ

Query:  QRDKSNIDLKP-KISRNAPKAPRNSKKTSNAETVPESMDTTSSSTTTEVANNPVVKPKGKAAPR---KAPAKKKQPQGKAAVLDDEDDEVLELKDRLAAY
        Q + + I  KP K+        +   K   AE +P       S     V      + K +A  R   K  ++K +   K       D E   LK RLA  
Subjt:  QRDKSNIDLKP-KISRNAPKAPRNSKKTSNAETVPESMDTTSSSTTTEVANNPVVKPKGKAAPR---KAPAKKKQPQGKAAVLDDEDDEVLELKDRLAAY

Query:  KIESSPEPSEVSVMETEVPQVQAAKKKEPSKRAAAKKKTTAKSAQISASDDDEDDFEIKEVAPPAAKKGGGRKAAANAKTTKPPAAAAKL----GQKLIT
        +                  + +   K++ +      KK        S SD + DDFE+     P+ ++   R+AAA  K      + A L          
Subjt:  KIESSPEPSEVSVMETEVPQVQAAKKKEPSKRAAAKKKTTAKSAQISASDDDEDDFEIKEVAPPAAKKGGGRKAAANAKTTKPPAAAAKL----GQKLIT

Query:  QMLEPAENSGISPEKKVRKIRASPFNKKSGSILGRTIGEE--------EEEAGNEDKVVGSASSETTEEVARFPAARGRSQRANRTQ
        +  E   +S  + +KK  K +A P  KK  +   + + +           E+ ++D      S    + V + PAA  +   A   Q
Subjt:  QMLEPAENSGISPEKKVRKIRASPFNKKSGSILGRTIGEE--------EEEAGNEDKVVGSASSETTEEVARFPAARGRSQRANRTQ
P08096 DNA topoisomerase 20.0e+0048.41Show/hide
Query:  MAVEKKRPLQNSNATNVDSNPAGPKKTIEEMYQKKSQLEHILLRPDTYVGSIEKHTQSLWVY--ENDKMVHRSISYVPGLYKIFDEILVNAADNKQRDPS
        M   ++ PL  +N  N +SN       +   YQ+ +  EH+L RPDTY+GSIE  T  +WV+  E +K+ +++++YVPGLYKIFDEI+VNAADNK RDP+
Subjt:  MAVEKKRPLQNSNATNVDSNPAGPKKTIEEMYQKKSQLEHILLRPDTYVGSIEKHTQSLWVY--ENDKMVHRSISYVPGLYKIFDEILVNAADNKQRDPS

Query:  MDSVKVNIDVEQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFNDNMGKK
        M+++KV +D E N IS++NNG G+P+EIH +EK+Y+PELIFG+LLTSSNYDD +KK TGGRNGYGAKL NIFSTEFV+ETAD +R+KKYKQ + DNM +K
Subjt:  MDSVKVNIDVEQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFNDNMGKK

Query:  SEPIITKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASTFQTEPPKRYHIKPNERWEI
        SEP+IT  K+ D +TK+TFKPDLAKF M  ++DD+V+++K+R+ D+AG + +T KV LN +R+ +  F+ YV++YL S +    EPP+  +   N+RW++
Subjt:  SEPIITKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASTFQTEPPKRYHIKPNERWEI

Query:  VVTLSEGQFQQVSFVNGISTIKGGTHVDYITNQIANYVMTVVNKKNKNANVKAHNVKSYLWVFINALIDNPSFDSQTKETLTKRPNSFGSACELTPEFLK
           +S+GQF+QVSFVN ISTI+GGTHV+Y+ N+I + +  VV K+NK A VKA  +K+Y+ VF+N  I+NPSFDSQTKETLT + ++FGS C L+ +FLK
Subjt:  VVTLSEGQFQQVSFVNGISTIKGGTHVDYITNQIANYVMTVVNKKNKNANVKAHNVKSYLWVFINALIDNPSFDSQTKETLTKRPNSFGSACELTPEFLK

Query:  NVATKSGIMDSVLSWVNFKQSKDLKKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQ
         +  KS +++ VL +   K  + L K DG    +I+G+ KLEDAN AG K S KC LILTEGDSAK+LA++GL VVGRD+YGVFPLRGKLLNVREAS  Q
Subjt:  NVATKSGIMDSVLSWVNFKQSKDLKKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQ

Query:  ITENKEIQYIKQILGLQQGKEYSNAKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLRVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWRES
        I  NKEIQ IK+I+G    K Y++ K LRYGHLMIMTDQDHDGSHIKGL+IN++ S +PSLL++P FL++FITPI+K T R   V +FYT+PEYE W+E+
Subjt:  ITENKEIQYIKQILGLQQGKEYSNAKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLRVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWRES

Query:  LRGNASGWSIKYYKGLGTSTSKEGREYFEQLTKHKKDFIWQDDNDGEAIELAFSKKKIEDRKNWLRQFEPGTHLDQTGRLIKYSDFVNKELILFSMADLQ
           N  GW IKYYKGLGTS   + + YF  L +H K F    + D E IE+AF+KKK + RK WLR + PG ++D T   I   DF+N+ELI FSMAD  
Subjt:  LRGNASGWSIKYYKGLGTSTSKEGREYFEQLTKHKKDFIWQDDNDGEAIELAFSKKKIEDRKNWLRQFEPGTHLDQTGRLIKYSDFVNKELILFSMADLQ

Query:  RSIPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLSN
        RSIPS+VDGLKPGQRK+++  FKRN + E KVS+ +GYV+  +AYHHGE S+  TI+ +AQ+FVGSNNINLL+PNGQFGTR+ GGK+ ++SRY+ T LS 
Subjt:  RSIPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLSN

Query:  VTRFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDIIRNVRRMLDGETMLPMDPWYRGFSGTIEKTATKEGGTSYT
        + R LF  +DD+LLNY N++GQ IEP +Y+PI+P VLVNG+EGIGTGWS+++PNYNP+DI  N+R ML+GE +  M PWYRGF G+I K A       Y 
Subjt:  VTRFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDIIRNVRRMLDGETMLPMDPWYRGFSGTIEKTATKEGGTSYT

Query:  VSGIIEEVSDTTLRIIELPVRRWTNDYKDFLDSVTRVASKHDKDKEKAAKDPFIEQADHHSDDKIVSIDVHLTEENMLLAIQEGLKKKFKLTTTVSTSNM
        +SGII ++ +  + I ELP+R WT D K++L++      K  K         FI   + H  +  V  +V LTE  M  A+ E L+ KFKL+ T +TSNM
Subjt:  VSGIIEEVSDTTLRIIELPVRRWTNDYKDFLDSVTRVASKHDKDKEKAAKDPFIEQADHHSDDKIVSIDVHLTEENMLLAIQEGLKKKFKLTTTVSTSNM

Query:  HLFDANGVIKKYDTPEQILEEFFPLRLEFYEKRKRNLLENLEMELLKLENKVRFILAVVNGEIIVSNRRKVDLFHELQAKGFTPF--PKKTKSAEPEVAG
          FDA+G IKKYD+ E IL EF+ +RL  Y++RK +++  LE    +  N+ RFI  ++ GE++VS ++K DL  EL+ K F P   PKK    + EV  
Subjt:  HLFDANGVIKKYDTPEQILEEFFPLRLEFYEKRKRNLLENLEMELLKLENKVRFILAVVNGEIIVSNRRKVDLFHELQAKGFTPF--PKKTKSAEPEVAG

Query:  ASNETDEAEESPEVVKGERVSDYEYLLAMAIGTLTIEKVQELCNDRDKLKGEVDDLRKATPKSLWLNDLDSLEKELDE-MDRNDAQAMEVRKQQRDKSN-
          N   E E+S +V + E    Y YLL+M + +LT E+  EL   +D++  E+D L K TPK LWL+DLD+ E   ++ MD    + +E  +  RD  N 
Subjt:  ASNETDEAEESPEVVKGERVSDYEYLLAMAIGTLTIEKVQELCNDRDKLKGEVDDLRKATPKSLWLNDLDSLEKELDE-MDRNDAQAMEVRKQQRDKSN-

Query:  IDLKPKISRNAPKAPRNSKKTSNAETVPESMDTTSSSTTTEVANNPVVKPKGKAAPRKAPAKKKQPQGKAAVLDDEDDEVLELKDRLAAYKIESSPEPSE
           KP+      + PR    +S++  V +   + S  +TT      ++    + A  K P K         V  +++   L +++   +         S 
Subjt:  IDLKPKISRNAPKAPRNSKKTSNAETVPESMDTTSSSTTTEVANNPVVKPKGKAAPRKAPAKKKQPQGKAAVLDDEDDEVLELKDRLAAYKIESSPEPSE

Query:  VSVMETEVPQVQAAKKKEPSKRAAAK-----KKTTAKSAQISASDDDEDDFEIKEVAP------PAAKKGGGRKAAANAK
         S   ++    + A  K+P K+ AA      +KT    A    S DDEDD     + P       A+ K  G+KA++  K
Subjt:  VSVMETEVPQVQAAKKKEPSKRAAAK-----KKTTAKSAQISASDDDEDDFEIKEVAP------PAAKKGGGRKAAANAK
P30182 DNA topoisomerase 20.0e+0063.85Show/hide
Query:  KRPLQNSNATNVDSNPAGPK-----KTIEEMYQKKSQLEHILLRPDTYVGSIEKHTQSLWVYENDKMVHRSISYVPGLYKIFDEILVNAADNKQRDPSMD
        K PLQNSNA NV   PA  +     KTIEEMYQKKSQLEHILLRPDTY+GSIEKHTQ+LWVYE D+MV R ++YVPGLYKIFDEILVNAADNKQRD  MD
Subjt:  KRPLQNSNATNVDSNPAGPK-----KTIEEMYQKKSQLEHILLRPDTYVGSIEKHTQSLWVYENDKMVHRSISYVPGLYKIFDEILVNAADNKQRDPSMD

Query:  SVKVNIDVEQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFNDNMGKKSE
        SV+V IDVEQN ISV N+G GVPVEIHQEE +YVPE+IFGHLLTSSNYDD  KKTTGGRNGYGAKLTNIFSTEF+IETADGKRLKKYKQVF +NMGKKSE
Subjt:  SVKVNIDVEQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFNDNMGKKSE

Query:  PIITKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASTFQTEPP-KRYHIKPNERWEIV
        P+ITKC + +NWTKVTFKPDL KFNMT LEDDVVALM KRV D+AGCLGK+VKVELNG+++PVKSF DYVDLYL +A+  +TE P  R   K N+RWE+ 
Subjt:  PIITKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASTFQTEPP-KRYHIKPNERWEIV

Query:  VTLSEGQFQQVSFVNGISTIKGGTHVDYITNQIANYVMTVVNKKNKNANVKAHNVKSYLWVFINALIDNPSFDSQTKETLTKRPNSFGSACELTPEFLKN
        V+LSEGQFQQVSFVN I+TIKGGTHVDY+T+QI N+++  VNKKNKNANVKAHNVK++LWVF+NALIDNP+FDSQTKETLT R +SFGS CEL+ +FLK 
Subjt:  VTLSEGQFQQVSFVNGISTIKGGTHVDYITNQIANYVMTVVNKKNKNANVKAHNVKSYLWVFINALIDNPSFDSQTKETLTKRPNSFGSACELTPEFLKN

Query:  VATKSGIMDSVLSWVNFKQSKDLKKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQI
        V  KSG+++++LSW +FKQ+KDLKK+DGAKT ++  +EKL+DA  AGGKNS  CTLILTEGDSAK+LA+AG  V+G ++ GVFPLRGKLLNVREAS+ QI
Subjt:  VATKSGIMDSVLSWVNFKQSKDLKKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQI

Query:  TENKEIQYIKQILGLQQGKEYSNAKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLRVPSFLVEFITPIVKATHRNGT--VLSFYTMPEYESWRE
        T NKEI+ +K+ILGL+Q  +Y N  +LRYG +MIMTDQDHDGSHIKGLLINFIHSFWPSLL+VPSFLVEFITPIVKAT R GT  VLSFY+MPEYE W+E
Subjt:  TENKEIQYIKQILGLQQGKEYSNAKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLRVPSFLVEFITPIVKATHRNGT--VLSFYTMPEYESWRE

Query:  SLRGNASGWSIKYYKGLGTSTSKEGREYFEQLTKHKKDFIWQDDNDGEAIELAFSKKKIEDRKNWLRQFEPGTHLDQTGRLIKYSDFVNKELILFSMADL
        SL+GNA+GW IKYYKGLGTST++EG+EYF  L  HKKDF+W+D+ DGEAIELAFSKKKIE RKNWL  + PG HLDQ    + YSDFVNKELILFSMADL
Subjt:  SLRGNASGWSIKYYKGLGTSTSKEGREYFEQLTKHKKDFIWQDDNDGEAIELAFSKKKIEDRKNWLRQFEPGTHLDQTGRLIKYSDFVNKELILFSMADL

Query:  QRSIPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLS
        QRSIPSMVDGLKPGQRKILF +FK+   KE KV+Q  GYVS  SAYHHGEQSLAS IIGMAQD+VGSNNINLLLPNGQFGTR  GGKD AS+RYI+TKLS
Subjt:  QRSIPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLS

Query:  NVTRFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDIIRNVRRMLDGETMLPMDPWYRGFSGTIEKTATKEGGTSY
         VTR LFPKDDD LL+YLNEDGQ IEPTWYMPIIPTVLVNG+EGIGTGWS+++PNYNPR+I+ NVRR+L+GE+M+PMDPWYRGF GTIEKTA+KEGG +Y
Subjt:  NVTRFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDIIRNVRRMLDGETMLPMDPWYRGFSGTIEKTATKEGGTSY

Query:  TVSGIIEEVSDTTLRIIELPVRRWTNDYKDFLDSVTRVASKHDKDKEKAAKDPFIEQADHHSDDKIVSIDVHLTEENMLLAIQEGLKKKFKLTTTVSTSN
        T++G+ EEV +TT+RI ELP+RRW +DYK+FL S+     K D         PF +    ++D+K V  D+ L+EENML A QEG  KKFKLTTT++TSN
Subjt:  TVSGIIEEVSDTTLRIIELPVRRWTNDYKDFLDSVTRVASKHDKDKEKAAKDPFIEQADHHSDDKIVSIDVHLTEENMLLAIQEGLKKKFKLTTTVSTSN

Query:  MHLFDANGVIKKYDTPEQILEEFFPLRLEFYEKRKRNLLENLEMELLKLENKVRFILAVVNGEIIVSNRRKVDLFHELQAKGFTPFPKKTKSAEPEVAGA
        MHLFD  GVIKKY TPEQILEEFF LR E+YEKRK  +++N+E+ELLKLENK RFILAV++GEIIV+ R+K D+  +L+ KGFTPFP+K +S E  +AGA
Subjt:  MHLFDANGVIKKYDTPEQILEEFFPLRLEFYEKRKRNLLENLEMELLKLENKVRFILAVVNGEIIVSNRRKVDLFHELQAKGFTPFPKKTKSAEPEVAGA

Query:  SNETDEAEESPEVVKGERV-------SDYEYLLAMAIGTLTIEKVQELCNDRDKLKGEVDDLRKATPKSLWLNDLDSLEKELDEMDRNDAQAMEV--RKQ
         ++ D AEE  E++            S+Y+YLLAMAI +LTIEKV+EL  DRDK+   V D++K TPKSLWL+DL+SL+KEL+++D  DAQ  +     Q
Subjt:  SNETDEAEESPEVVKGERV-------SDYEYLLAMAIGTLTIEKVQELCNDRDKLKGEVDDLRKATPKSLWLNDLDSLEKELDEMDRNDAQAMEV--RKQ

Query:  QRDKSNIDLKPKISRNAPKAPRNSKKTSNAETVPESMDTTSSSTTTEVANN--PVVKPKGKAAPRKAPAKKKQPQGKAAVLDDEDD--EVLELKDRLAAY
        ++ ++      K+ R APK P   K T  A    ES  T +S +  +  NN   VVKPK +   +K  ++ +  +   + +D +++  EV++ K R  A 
Subjt:  QRDKSNIDLKPKISRNAPKAPRNSKKTSNAETVPESMDTTSSSTTTEVANN--PVVKPKGKAAPRKAPAKKKQPQGKAAVLDDEDD--EVLELKDRLAAY

Query:  KIESSPEPSEVSVMETEVPQVQAAKKKEPSKRAAAKKKTTAKSAQISASDDDEDDFEIKEVAPPAAKKGGGRKAAANAKTTKPPAAAAKLGQKLI--TQM
        K   +P  ++  V E E+  +     +     A A    TA++++  A DDD+DD  + EVAP    K GGRK AA  K  KPPAA  K G++ +  T++
Subjt:  KIESSPEPSEVSVMETEVPQVQAAKKKEPSKRAAAKKKTTAKSAQISASDDDEDDFEIKEVAPPAAKKGGGRKAAANAKTTKPPAAAAKLGQKLI--TQM

Query:  LEPAENSGISPEKKVRKIRASPFNKKSGSILGRTIGEEEEEAGNEDKVVGSASSETTEEVARFPAARGRSQRANRTQVRYVVSDSDNDVSEASDFDE-EA
        L      G+SPEKKVRK+R+SPFNKKS S++ R    +EEE  + + V G++SSE +       +A  R QRANR ++ YV+SDS+++ +  S+FD+ E 
Subjt:  LEPAENSGISPEKKVRKIRASPFNKKSGSILGRTIGEEEEEAGNEDKVVGSASSETTEEVARFPAARGRSQRANRTQVRYVVSDSDNDVSEASDFDE-EA

Query:  SLDEE
          D+E
Subjt:  SLDEE
Q55BP5 Probable DNA topoisomerase 20.0e+0046.7Show/hide
Query:  EKKRPLQNSNATNVDSNPAGPKKTIEEMYQKKSQLEHILLRPDTYVGSIEKHTQSLWVYENDKMVHRSISYVPGLYKIFDEILVNAADNKQRDPSMDSVK
        +K     N N     ++ A   K+IEE+YQKK  L+ ILLRPDTY+GS E+  + LWV+E+ +MVHR +S+VPG+YKIFDEILVNAADNKQR+ +M  +K
Subjt:  EKKRPLQNSNATNVDSNPAGPKKTIEEMYQKKSQLEHILLRPDTYVGSIEKHTQSLWVYENDKMVHRSISYVPGLYKIFDEILVNAADNKQRDPSMDSVK

Query:  VNIDVEQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFNDNMGKKSEPII
        V ID E+  ISV N+G G+P+++H E K+Y+PELIFG+LLTSS+YDD+EK+ TGGRNG+GAKL NIFST+F++E AD K  K YKQ F +NM  K +P I
Subjt:  VNIDVEQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFNDNMGKKSEPII

Query:  TKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASTFQTEPPKRYHIKPNERWEIVVTLS
        T  +   ++TK+TF P+L +F M   +DD+VAL+ KRV D+AGC   T+KV LN + + ++SF+ Y++LY       +   PK Y+ K ++RWE+ VTLS
Subjt:  TKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASTFQTEPPKRYHIKPNERWEIVVTLS

Query:  -EGQFQQVSFVNGISTIKGGTHVDYITNQIANYVMTVVNKKNK-NANVKAHNVKSYLWVFINALIDNPSFDSQTKETLTKRPNSFGSACELTPEFLKNVA
         E QF QVSFVN I T+KGGTHV +  + I   +   VNKKNK +A++K   +K++L VF+N LI+NP FDSQTKETLT + +SFGS CE + +F+K V 
Subjt:  -EGQFQQVSFVNGISTIKGGTHVDYITNQIANYVMTVVNKKNK-NANVKAHNVKSYLWVFINALIDNPSFDSQTKETLTKRPNSFGSACELTPEFLKNVA

Query:  -TKSGIMDSVLSWVNFKQSKDLKK--TDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQ
         +KSGI+ S+L +  FK    LK+  + G K  K+S I KL+DAN AGG  SE CTLILTEGDSAK+LA AG+ VVG+D YG FPL+GKLLNVR+ S+K 
Subjt:  -TKSGIMDSVLSWVNFKQSKDLKK--TDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQ

Query:  ITENKEIQYIKQILGLQQGKEYSNAKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLRVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWRES
        +  N EI  I  ILGL+ GK Y     LRYGHLMIMTDQDHDGSHIKGL+IN +H FWP+LLR+P FLVEFITPIVK    N   +SFYTMPE+  WRE+
Subjt:  ITENKEIQYIKQILGLQQGKEYSNAKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLRVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWRES

Query:  LRGNASGWSIKYYKGLGTSTSKEGREYFEQLTKHKKDFIWQDDNDGEAIELAFSKKKIEDRKNWLRQFEPGTHLDQTG-RLIKYSDFVNKELILFSMADL
           N  GW +KYYKGLGTST  EG+EYF  L +HK DF W D+   + IELAFSK + +DRK W+ +   GT L+Q G + + YSDF+NKEL+LFS+AD 
Subjt:  LRGNASGWSIKYYKGLGTSTSKEGREYFEQLTKHKKDFIWQDDNDGEAIELAFSKKKIEDRKNWLRQFEPGTHLDQTG-RLIKYSDFVNKELILFSMADL

Query:  QRSIPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLS
        +RSIP++VDGLK   RK L+  FKRN  KE KV+Q  GYVSEHSAYHHGE SL STI+GMAQ+FVGSNNINLL P G +GTR  GGKD +S+RYI+T+L+
Subjt:  QRSIPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLS

Query:  NVTRFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDIIRNVRRMLDGETMLPMDPWYRGFSGTIE-KTATKEGGTS
        ++ R ++  DDD +L+ + +DG+ ++P +Y+P+IP +LVNG  GIGTGWSS +PNYNPRD+I+N+R  +DG+ + P+ PWYRGF G+IE    +K  G  
Subjt:  NVTRFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDIIRNVRRMLDGETMLPMDPWYRGFSGTIE-KTATKEGGTS

Query:  YTVSGIIEEVSDTTLRIIELPVRRWTNDYKDFLDSV----TRVASKHDKDKEKA------AKDPFIEQADHHSDD----KIVSIDV------------HL
        Y   GI +++SD    I ELP+  WT DY++ LD +    TR   K +K+K+ A      AK    +++    DD    K+    V            H 
Subjt:  YTVSGIIEEVSDTTLRIIELPVRRWTNDYKDFLDSV----TRVASKHDKDKEKA------AKDPFIEQADHHSDD----KIVSIDV------------HL

Query:  TEENMLLAIQEGLKKKFKLTTTVSTSNMHLFDANGVIKKYDTPEQILEEFFPLRLEFYEKRKRNLLENLEMELLKLENKVRFILAVVNGEIIVSNRRKVD
          + +    +  ++K FKL +T++ +NM +FD  G I+++ T   + E FFPLR++ Y+ RK  L E L  E  +L NK RFILAVVN E+++SN +KVD
Subjt:  TEENMLLAIQEGLKKKFKLTTTVSTSNMHLFDANGVIKKYDTPEQILEEFFPLRLEFYEKRKRNLLENLEMELLKLENKVRFILAVVNGEIIVSNRRKVD

Query:  LFHELQAKGFTPFPKK--TKSAEPEVAGASNETDE------AEESPEVVKGERVSD---YEYLLAMAIGTLTIEKVQELCNDRDKLKGEVDDLRKATPKS
        L ++L+   F     K   KSA  ++    N  DE      ++E  +  + E+  D   Y+YLL++ + +LT+E+V++L  +RD  K E D L     + 
Subjt:  LFHELQAKGFTPFPKK--TKSAEPEVAGASNETDE------AEESPEVVKGERVSD---YEYLLAMAIGTLTIEKVQELCNDRDKLKGEVDDLRKATPKS

Query:  LWLNDLDSLEKELDEMDRNDAQAMEVRKQQRDKSNIDLKPKISRNAPKAPRNSKKTSNAETV-------------------PESMDTTSSSTTTEVANN-
        ++  DLD+LEK LD+ D  D       +  + ++     P+  + + K  +++K+    + V                    +S DTTS+ST+T  ++N 
Subjt:  LWLNDLDSLEKELDEMDRNDAQAMEVRKQQRDKSNIDLKPKISRNAPKAPRNSKKTSNAETV-------------------PESMDTTSSSTTTEVANN-

Query:  -PVVKPKGKAAPRKAPAKKKQP-QGKAAVLDDEDDEVLELKDRLAAYKIESSPEPSEVSVMETEVPQVQAAKKKEPSKRA----------AAKKKTTAKS
         P+     K   +  PA KK       +  D +DD V+  K +    K     E S+ S  E++    Q +  + P KR+          A KK TT+KS
Subjt:  -PVVKPKGKAAPRKAPAKKKQP-QGKAAVLDDEDDEVLELKDRLAAYKIESSPEPSEVSVMETEVPQVQAAKKKEPSKRA----------AAKKKTTAKS

Query:  AQI-SASDDDE
          I   S DDE
Subjt:  AQI-SASDDDE
Arabidopsis top hitse value%identityAlignment
AT3G10270.1 DNA GYRASE B13.3e-2323.65Show/hide
Query:  GLYKIFDEILVNAADNKQRDPSMDSVKVNIDV---EQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDTEK--KTTGGRNGYGAKLTNIFS
        GL+ +  EIL NA D  Q           IDV     + +S+ +NG G+P ++H        E +   L     +         +GG +G G  + N  S
Subjt:  GLYKIFDEILVNAADNKQRDPSMDSVKVNIDV---EQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDTEK--KTTGGRNGYGAKLTNIFS

Query:  TEF-VIETADGKRLKKYKQVFNDNMGKKSEPIIT-KC------KEGDNWTKVTFKPDLAKFNMT-HLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVP
            VI   DG    +++Q ++     + +P+ T  C        G   T + F PD   F      + + +A   + +  L   +  ++K E +     
Subjt:  TEF-VIETADGKRLKKYKQVFNDNMGKKSEPIIT-KC------KEGDNWTKVTFKPDLAKFNMT-HLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVP

Query:  VKSFQDYVDLYLKSASTFQTEPPKRYHIKPNERWEIVVTLSEGQFQ---------QVSFVNGISTIKGGTHVDYITNQIANYVMTVVNK-----------
        V S   Y     +  S   T+  K  H     R EI  +  +   Q          + + N I TI GGTH++ +   +   + ++  K           
Subjt:  VKSFQDYVDLYLKSASTFQTEPPKRYHIKPNERWEIVVTLSEGQFQ---------QVSFVNGISTIKGGTHVDYITNQIANYVMTVVNK-----------

Query:  -------------------------KNKNANVKAHNVKSYLWVFINALIDNPSFDSQTKETL----------TKRPNSFGSACELTPEFLKNVATKSGIM
                                   K+ ++   +V+  L   ++  + NP F+ QTK  L                     EL P+ L+++ +KS  +
Subjt:  -------------------------KNKNANVKAHNVKSYLWVFINALIDNPSFDSQTKETL----------TKRPNSFGSACELTPEFLKNVATKSGIM

Query:  DSVLSWVNFKQSKDLKKTDGA-KTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQITENKEIQ
        ++  + +  K++++L ++    K+  + G  KL D +      SE   + + EGDSA   A  G     R F  + PLRGK+LN+       + +N+EIQ
Subjt:  DSVLSWVNFKQSKDLKKTDGA-KTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQITENKEIQ

Query:  YIKQILGLQQGKEYSNAKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLRVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWRESLRGNASGW
         +   LGL    E  N + LRY  ++I+TD D DG+HI+ LL+ F   +  +L       V  + P+ K   R       Y     +    S  GNAS +
Subjt:  YIKQILGLQQGKEYSNAKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLRVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWRESLRGNASGW

Query:  SIKYYKGLG
        +I+ +KGLG
Subjt:  SIKYYKGLG
AT3G23890.1 topoisomerase II0.0e+0063.85Show/hide
Query:  KRPLQNSNATNVDSNPAGPK-----KTIEEMYQKKSQLEHILLRPDTYVGSIEKHTQSLWVYENDKMVHRSISYVPGLYKIFDEILVNAADNKQRDPSMD
        K PLQNSNA NV   PA  +     KTIEEMYQKKSQLEHILLRPDTY+GSIEKHTQ+LWVYE D+MV R ++YVPGLYKIFDEILVNAADNKQRD  MD
Subjt:  KRPLQNSNATNVDSNPAGPK-----KTIEEMYQKKSQLEHILLRPDTYVGSIEKHTQSLWVYENDKMVHRSISYVPGLYKIFDEILVNAADNKQRDPSMD

Query:  SVKVNIDVEQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFNDNMGKKSE
        SV+V IDVEQN ISV N+G GVPVEIHQEE +YVPE+IFGHLLTSSNYDD  KKTTGGRNGYGAKLTNIFSTEF+IETADGKRLKKYKQVF +NMGKKSE
Subjt:  SVKVNIDVEQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFNDNMGKKSE

Query:  PIITKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASTFQTEPP-KRYHIKPNERWEIV
        P+ITKC + +NWTKVTFKPDL KFNMT LEDDVVALM KRV D+AGCLGK+VKVELNG+++PVKSF DYVDLYL +A+  +TE P  R   K N+RWE+ 
Subjt:  PIITKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASTFQTEPP-KRYHIKPNERWEIV

Query:  VTLSEGQFQQVSFVNGISTIKGGTHVDYITNQIANYVMTVVNKKNKNANVKAHNVKSYLWVFINALIDNPSFDSQTKETLTKRPNSFGSACELTPEFLKN
        V+LSEGQFQQVSFVN I+TIKGGTHVDY+T+QI N+++  VNKKNKNANVKAHNVK++LWVF+NALIDNP+FDSQTKETLT R +SFGS CEL+ +FLK 
Subjt:  VTLSEGQFQQVSFVNGISTIKGGTHVDYITNQIANYVMTVVNKKNKNANVKAHNVKSYLWVFINALIDNPSFDSQTKETLTKRPNSFGSACELTPEFLKN

Query:  VATKSGIMDSVLSWVNFKQSKDLKKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQI
        V  KSG+++++LSW +FKQ+KDLKK+DGAKT ++  +EKL+DA  AGGKNS  CTLILTEGDSAK+LA+AG  V+G ++ GVFPLRGKLLNVREAS+ QI
Subjt:  VATKSGIMDSVLSWVNFKQSKDLKKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQI

Query:  TENKEIQYIKQILGLQQGKEYSNAKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLRVPSFLVEFITPIVKATHRNGT--VLSFYTMPEYESWRE
        T NKEI+ +K+ILGL+Q  +Y N  +LRYG +MIMTDQDHDGSHIKGLLINFIHSFWPSLL+VPSFLVEFITPIVKAT R GT  VLSFY+MPEYE W+E
Subjt:  TENKEIQYIKQILGLQQGKEYSNAKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLRVPSFLVEFITPIVKATHRNGT--VLSFYTMPEYESWRE

Query:  SLRGNASGWSIKYYKGLGTSTSKEGREYFEQLTKHKKDFIWQDDNDGEAIELAFSKKKIEDRKNWLRQFEPGTHLDQTGRLIKYSDFVNKELILFSMADL
        SL+GNA+GW IKYYKGLGTST++EG+EYF  L  HKKDF+W+D+ DGEAIELAFSKKKIE RKNWL  + PG HLDQ    + YSDFVNKELILFSMADL
Subjt:  SLRGNASGWSIKYYKGLGTSTSKEGREYFEQLTKHKKDFIWQDDNDGEAIELAFSKKKIEDRKNWLRQFEPGTHLDQTGRLIKYSDFVNKELILFSMADL

Query:  QRSIPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLS
        QRSIPSMVDGLKPGQRKILF +FK+   KE KV+Q  GYVS  SAYHHGEQSLAS IIGMAQD+VGSNNINLLLPNGQFGTR  GGKD AS+RYI+TKLS
Subjt:  QRSIPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLS

Query:  NVTRFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDIIRNVRRMLDGETMLPMDPWYRGFSGTIEKTATKEGGTSY
         VTR LFPKDDD LL+YLNEDGQ IEPTWYMPIIPTVLVNG+EGIGTGWS+++PNYNPR+I+ NVRR+L+GE+M+PMDPWYRGF GTIEKTA+KEGG +Y
Subjt:  NVTRFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDIIRNVRRMLDGETMLPMDPWYRGFSGTIEKTATKEGGTSY

Query:  TVSGIIEEVSDTTLRIIELPVRRWTNDYKDFLDSVTRVASKHDKDKEKAAKDPFIEQADHHSDDKIVSIDVHLTEENMLLAIQEGLKKKFKLTTTVSTSN
        T++G+ EEV +TT+RI ELP+RRW +DYK+FL S+     K D         PF +    ++D+K V  D+ L+EENML A QEG  KKFKLTTT++TSN
Subjt:  TVSGIIEEVSDTTLRIIELPVRRWTNDYKDFLDSVTRVASKHDKDKEKAAKDPFIEQADHHSDDKIVSIDVHLTEENMLLAIQEGLKKKFKLTTTVSTSN

Query:  MHLFDANGVIKKYDTPEQILEEFFPLRLEFYEKRKRNLLENLEMELLKLENKVRFILAVVNGEIIVSNRRKVDLFHELQAKGFTPFPKKTKSAEPEVAGA
        MHLFD  GVIKKY TPEQILEEFF LR E+YEKRK  +++N+E+ELLKLENK RFILAV++GEIIV+ R+K D+  +L+ KGFTPFP+K +S E  +AGA
Subjt:  MHLFDANGVIKKYDTPEQILEEFFPLRLEFYEKRKRNLLENLEMELLKLENKVRFILAVVNGEIIVSNRRKVDLFHELQAKGFTPFPKKTKSAEPEVAGA

Query:  SNETDEAEESPEVVKGERV-------SDYEYLLAMAIGTLTIEKVQELCNDRDKLKGEVDDLRKATPKSLWLNDLDSLEKELDEMDRNDAQAMEV--RKQ
         ++ D AEE  E++            S+Y+YLLAMAI +LTIEKV+EL  DRDK+   V D++K TPKSLWL+DL+SL+KEL+++D  DAQ  +     Q
Subjt:  SNETDEAEESPEVVKGERV-------SDYEYLLAMAIGTLTIEKVQELCNDRDKLKGEVDDLRKATPKSLWLNDLDSLEKELDEMDRNDAQAMEV--RKQ

Query:  QRDKSNIDLKPKISRNAPKAPRNSKKTSNAETVPESMDTTSSSTTTEVANN--PVVKPKGKAAPRKAPAKKKQPQGKAAVLDDEDD--EVLELKDRLAAY
        ++ ++      K+ R APK P   K T  A    ES  T +S +  +  NN   VVKPK +   +K  ++ +  +   + +D +++  EV++ K R  A 
Subjt:  QRDKSNIDLKPKISRNAPKAPRNSKKTSNAETVPESMDTTSSSTTTEVANN--PVVKPKGKAAPRKAPAKKKQPQGKAAVLDDEDD--EVLELKDRLAAY

Query:  KIESSPEPSEVSVMETEVPQVQAAKKKEPSKRAAAKKKTTAKSAQISASDDDEDDFEIKEVAPPAAKKGGGRKAAANAKTTKPPAAAAKLGQKLI--TQM
        K   +P  ++  V E E+  +     +     A A    TA++++  A DDD+DD  + EVAP    K GGRK AA  K  KPPAA  K G++ +  T++
Subjt:  KIESSPEPSEVSVMETEVPQVQAAKKKEPSKRAAAKKKTTAKSAQISASDDDEDDFEIKEVAPPAAKKGGGRKAAANAKTTKPPAAAAKLGQKLI--TQM

Query:  LEPAENSGISPEKKVRKIRASPFNKKSGSILGRTIGEEEEEAGNEDKVVGSASSETTEEVARFPAARGRSQRANRTQVRYVVSDSDNDVSEASDFDE-EA
        L      G+SPEKKVRK+R+SPFNKKS S++ R    +EEE  + + V G++SSE +       +A  R QRANR ++ YV+SDS+++ +  S+FD+ E 
Subjt:  LEPAENSGISPEKKVRKIRASPFNKKSGSILGRTIGEEEEEAGNEDKVVGSASSETTEEVARFPAARGRSQRANRTQVRYVVSDSDNDVSEASDFDE-EA

Query:  SLDEE
          D+E
Subjt:  SLDEE
AT3G23890.2 topoisomerase II0.0e+0064.34Show/hide
Query:  KRPLQNSNATNVDSNPAGPK-----KTIEEMYQKKSQLEHILLRPDTYVGSIEKHTQSLWVYENDKMVHRSISYVPGLYKIFDEILVNAADNKQRDPSMD
        K PLQNSNA NV   PA  +     KTIEEMYQKKSQLEHILLRPDTY+GSIEKHTQ+LWVYE D+MV R ++YVPGLYKIFDEILVNAADNKQRD  MD
Subjt:  KRPLQNSNATNVDSNPAGPK-----KTIEEMYQKKSQLEHILLRPDTYVGSIEKHTQSLWVYENDKMVHRSISYVPGLYKIFDEILVNAADNKQRDPSMD

Query:  SVKVNIDVEQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFNDNMGKKSE
        SV+V IDVEQN ISV N+G GVPVEIHQEE +YVPE+IFGHLLTSSNYDD  KKTTGGRNGYGAKLTNIFSTEF+IETADGKRLKKYKQVF +NMGKKSE
Subjt:  SVKVNIDVEQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFNDNMGKKSE

Query:  PIITKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASTFQTEPP-KRYHIKPNERWEIV
        P+ITKC + +NWTKVTFKPDL KFNMT LEDDVVALM KRV D+AGCLGK+VKVELNG+++PVKSF DYVDLYL +A+  +TE P  R   K N+RWE+ 
Subjt:  PIITKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASTFQTEPP-KRYHIKPNERWEIV

Query:  VTLSEGQFQQVSFVNGISTIKGGTHVDYITNQIANYVMTVVNKKNKNANVKAHNVKSYLWVFINALIDNPSFDSQTKETLTKRPNSFGSACELTPEFLKN
        V+LSEGQFQQVSFVN I+TIKGGTHVDY+T+QI N+++  VNKKNKNANVKAHNVK++LWVF+NALIDNP+FDSQTKETLT R +SFGS CEL+ +FLK 
Subjt:  VTLSEGQFQQVSFVNGISTIKGGTHVDYITNQIANYVMTVVNKKNKNANVKAHNVKSYLWVFINALIDNPSFDSQTKETLTKRPNSFGSACELTPEFLKN

Query:  VATKSGIMDSVLSWVNFKQSKDLKKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQI
        V  KSG+++++LSW +FKQ+KDLKK+DGAKT ++  +EKL+DA  AGGKNS  CTLILTEGDSAK+LA+AG  V+G ++ GVFPLRGKLLNVREAS+ QI
Subjt:  VATKSGIMDSVLSWVNFKQSKDLKKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQI

Query:  TENKEIQYIKQILGLQQGKEYSNAKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLRVPSFLVEFITPIVKATHRNGT--VLSFYTMPEYESWRE
        T NKEI+ +K+ILGL+Q  +Y N  +LRYG +MIMTDQDHDGSHIKGLLINFIHSFWPSLL+VPSFLVEFITPIVKAT R GT  VLSFY+MPEYE W+E
Subjt:  TENKEIQYIKQILGLQQGKEYSNAKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLRVPSFLVEFITPIVKATHRNGT--VLSFYTMPEYESWRE

Query:  SLRGNASGWSIKYYKGLGTSTSKEGREYFEQLTKHKKDFIWQDDNDGEAIELAFSKKKIEDRKNWLRQFEPGTHLDQTGRLIKYSDFVNKELILFSMADL
        SL+GNA+GW IKYYKGLGTST++EG+EYF  L  HKKDF+W+D+ DGEAIELAFSKKKIE RKNWL  + PG HLDQ    + YSDFVNKELILFSMADL
Subjt:  SLRGNASGWSIKYYKGLGTSTSKEGREYFEQLTKHKKDFIWQDDNDGEAIELAFSKKKIEDRKNWLRQFEPGTHLDQTGRLIKYSDFVNKELILFSMADL

Query:  QRSIPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLS
        QRSIPSMVDGLKPGQRKILF +FK+   KE KV+Q  GYVS  SAYHHGEQSLAS IIGMAQD+VGSNNINLLLPNGQFGTR  GGKD AS+RYI+TKLS
Subjt:  QRSIPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLS

Query:  NVTRFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDIIRNVRRMLDGETMLPMDPWYRGFSGTIEKTATKEGGTSY
         VTR LFPKDDD LL+YLNEDGQ IEPTWYMPIIPTVLVNG+EGIGTGWS+++PNYNPR+I+ NVRR+L+GE+M+PMDPWYRGF GTIEKTA+KEGG +Y
Subjt:  NVTRFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDIIRNVRRMLDGETMLPMDPWYRGFSGTIEKTATKEGGTSY

Query:  TVSGIIEEVSDTTLRIIELPVRRWTNDYKDFLDSVTRVASKHDKDKEKAAKDPFIEQADHHSDDKIVSIDVHLTEENMLLAIQEGLKKKFKLTTTVSTSN
        T++G+ EEV +TT+RI ELP+RRW +DYK+FL S+     K D         PF +    ++D+K V  D+ L+EENML A QEG  KKFKLTTT++TSN
Subjt:  TVSGIIEEVSDTTLRIIELPVRRWTNDYKDFLDSVTRVASKHDKDKEKAAKDPFIEQADHHSDDKIVSIDVHLTEENMLLAIQEGLKKKFKLTTTVSTSN

Query:  MHLFDANGVIKKYDTPEQILEEFFPLRLEFYEKRKRNLLENLEMELLKLENKVRFILAVVNGEIIVSNRRKVDLFHELQAKGFTPFPKKTKSAEPEVAGA
        MHLFD  GVIKKY TPEQILEEFF LR E+YEKRK  +++N+E+ELLKLENK RFILAV++GEIIV+ R+K D+  +L+ KGFTPFP+K +S E  +AGA
Subjt:  MHLFDANGVIKKYDTPEQILEEFFPLRLEFYEKRKRNLLENLEMELLKLENKVRFILAVVNGEIIVSNRRKVDLFHELQAKGFTPFPKKTKSAEPEVAGA

Query:  SNETDEAEESPEVVKGERV-------SDYEYLLAMAIGTLTIEKVQELCNDRDKLKGEVDDLRKATPKSLWLNDLDSLEKELDEMDRNDAQAMEV--RKQ
         ++ D AEE  E++            S+Y+YLLAMAI +LTIEKV+EL  DRDK+   V D++K TPKSLWL+DL+SL+KEL+++D  DAQ  +     Q
Subjt:  SNETDEAEESPEVVKGERV-------SDYEYLLAMAIGTLTIEKVQELCNDRDKLKGEVDDLRKATPKSLWLNDLDSLEKELDEMDRNDAQAMEV--RKQ

Query:  QRDKSNIDLKPKISRNAPKAPRNSKKTSNAETVPESMDTTSSSTTTEVANN--PVVKPKGKAAPRKAPAKKKQPQGKAAVLDDEDDEVLELKDRLAAYKI
        ++ ++      K+ R APK P   K T  A    ES  T +S +  +  NN   VVKPKG+       AKKK P   AA  + E+DE+L+L  RLA Y  
Subjt:  QRDKSNIDLKPKISRNAPKAPRNSKKTSNAETVPESMDTTSSSTTTEVANN--PVVKPKGKAAPRKAPAKKKQPQGKAAVLDDEDDEVLELKDRLAAYKI

Query:  ESSPEPSEVSVMETEVPQVQAAKKKEPSKRAAAKKKTTAKSAQISASDDDEDDFEIKEVAPPAAKKGGGRKAAANAKTTKPPAAAAKLGQKLI--TQMLE
         S+P                            A    TA++++  A DDD+DD  + EVAP    K GGRK AA  K  KPPAA  K G++ +  T++L 
Subjt:  ESSPEPSEVSVMETEVPQVQAAKKKEPSKRAAAKKKTTAKSAQISASDDDEDDFEIKEVAPPAAKKGGGRKAAANAKTTKPPAAAAKLGQKLI--TQMLE

Query:  PAENSGISPEKKVRKIRASPFNKKSGSILGRTIGEEEEEAGNEDKVVGSASSETTEEVARFPAARGRSQRANRTQVRYVVSDSDNDVSEASDFDE-EASL
             G+SPEKKVRK+R+SPFNKKS S++ R    +EEE  + + V G++SSE +       +A  R QRANR ++ YV+SDS+++ +  S+FD+ E   
Subjt:  PAENSGISPEKKVRKIRASPFNKKSGSILGRTIGEEEEEAGNEDKVVGSASSETTEEVARFPAARGRSQRANRTQVRYVVSDSDNDVSEASDFDE-EASL

Query:  DEE
        D+E
Subjt:  DEE
AT5G04130.1 DNA GYRASE B21.0e-2723.7Show/hide
Query:  ATNVDSNPAGPKKTIEEMYQKKSQLEHILLRPDTYVGSIEKHTQSLWVYENDKMVHRSISYVPGLYKIFDEILVNAADNKQRDPSMDSVKVNIDVE-QNC
        +T         K    E  Q    L+ +  RP  Y+GS                         GL+ +  EIL NA D  Q   +    KV++ +     
Subjt:  ATNVDSNPAGPKKTIEEMYQKKSQLEHILLRPDTYVGSIEKHTQSLWVYENDKMVHRSISYVPGLYKIFDEILVNAADNKQRDPSMDSVKVNIDVE-QNC

Query:  ISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDTEK--KTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFNDNMGKKSEPIIT-KCK--
        +SV +NG G+P ++H   K    E +   L     +  T      +GG +G G  + N  S    +E +  +   ++KQ ++     + +PI T  C+  
Subjt:  ISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDTEK--KTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFNDNMGKKSEPIIT-KCK--

Query:  ----EGDNWTKVTFKPDLAKFNMT-HLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASTFQTEPPKRYHIKPNERWEIVVTL
            +G   T + F PD   F      + + +A   + +  L   +  ++K E +       S   +     +  S   T+     H     R EI    
Subjt:  ----EGDNWTKVTFKPDLAKFNMT-HLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASTFQTEPPKRYHIKPNERWEIVVTL

Query:  SEGQFQ---------QVSFVNGISTIKGGTHVDYITNQIANYVMTVVNK----KNKNANVKAHNVKSYLWVFINALIDNPSFDSQTKETL----------
         +   Q          + + N I TI GGTH++ +   +   + T+  K    K K+ ++   +V+  L   ++  + NP F+ QTK  L          
Subjt:  SEGQFQ---------QVSFVNGISTIKGGTHVDYITNQIANYVMTVVNK----KNKNANVKAHNVKSYLWVFINALIDNPSFDSQTKETL----------

Query:  TKRPNSFGSACELTPEFLKNVATKSGIMDSVLSWVNFKQSKDLKKTDGA-KTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDF
                   EL P+ L+++ +KS  +++  + +  K++++L ++    K+  + G  KL D +    + SE   + + EGDSA   A  G     R F
Subjt:  TKRPNSFGSACELTPEFLKNVATKSGIMDSVLSWVNFKQSKDLKKTDGA-KTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDF

Query:  YGVFPLRGKLLNVREASSKQITENKEIQYIKQILGLQQGKEYSNAKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLRVPSFLVEFITPIVKATH
          + PLRGK+LN+       + +N+EIQ +   LGL    E    + LRY  ++I+TD D DG+HI+ LL+ F   +  +L       V  + P+ K   
Subjt:  YGVFPLRGKLLNVREASSKQITENKEIQYIKQILGLQQGKEYSNAKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLRVPSFLVEFITPIVKATH

Query:  RNGTVLSFYTMPEYESWRESLRGNASGWSIKYYKGLG
        R       Y   + +    +   NAS ++I+ +KGLG
Subjt:  RNGTVLSFYTMPEYESWRESLRGNASGWSIKYYKGLG

Sequences Show/hide sequences
CDS sequenceShow/hide CDS sequence
ATGGCTGTGGAGAAGAAACGCCCACTGCAGAATAGCAACGCCACCAATGTCGACTCCAATCCGGCAGGTCCAAAGAAAACAATCGAAGAAATGTACCAGAAGAAGTCTCA
GCTCGAGCACATTCTCCTCAGGCCCGATACCTATGTCGGATCTATTGAAAAGCACACCCAAAGCCTCTGGGTTTACGAGAACGACAAAATGGTCCACCGATCCATCTCCT
ACGTGCCTGGTCTTTACAAGATCTTTGATGAAATTTTGGTCAATGCTGCTGATAATAAGCAGAGAGACCCTTCGATGGATTCAGTTAAGGTCAATATTGACGTCGAACAG
AACTGTATCAGTGTGTTCAACAACGGAGATGGAGTTCCGGTTGAAATTCATCAGGAAGAGAAGGTTTATGTGCCTGAGTTGATCTTTGGACATCTCTTGACTAGTAGTAA
CTATGATGACACTGAAAAGAAAACAACTGGTGGACGCAATGGCTATGGTGCGAAACTTACCAATATTTTTTCTACTGAATTTGTGATCGAGACAGCTGATGGAAAACGCC
TAAAGAAGTATAAGCAGGTATTCAATGATAACATGGGGAAAAAATCTGAGCCGATTATAACAAAGTGCAAGGAGGGTGATAATTGGACCAAGGTAACTTTTAAGCCAGAC
TTGGCAAAGTTCAACATGACTCATCTTGAAGATGATGTTGTTGCACTGATGAAGAAGAGAGTGTTGGATTTGGCTGGATGCCTTGGTAAAACCGTGAAGGTTGAGCTGAA
TGGACAAAGGGTCCCTGTTAAATCATTTCAAGATTATGTAGATCTCTACCTCAAATCAGCATCCACATTCCAGACGGAACCTCCAAAAAGGTATCACATTAAGCCTAATG
AGAGATGGGAAATTGTTGTGACCTTAAGTGAGGGCCAGTTCCAGCAGGTCAGCTTTGTGAACGGGATTTCAACTATTAAGGGTGGGACTCATGTTGATTACATCACTAAT
CAAATTGCAAATTATGTGATGACTGTTGTAAATAAGAAGAACAAAAATGCTAACGTGAAGGCCCACAATGTGAAGAGCTATTTGTGGGTTTTTATCAATGCTCTCATTGA
TAATCCATCCTTCGACTCCCAAACCAAGGAAACTTTGACAAAACGTCCAAACAGTTTCGGTTCTGCATGCGAACTTACGCCGGAGTTTTTGAAGAATGTGGCCACAAAAT
CTGGAATTATGGACAGCGTTCTCTCATGGGTTAATTTCAAGCAAAGCAAAGACCTAAAGAAAACAGATGGAGCAAAAACAGAAAAGATTAGTGGTATAGAAAAGTTGGAG
GATGCCAATTGCGCTGGAGGGAAGAACTCAGAAAAATGTACCTTAATTTTGACGGAAGGAGATTCAGCTAAGGCCCTTGCAATGGCTGGGCTCGGTGTAGTAGGGCGAGA
TTTTTATGGTGTATTCCCACTAAGAGGTAAATTGCTCAATGTGAGGGAAGCAAGTAGTAAACAGATCACAGAGAATAAAGAAATTCAATACATCAAGCAAATTCTTGGAC
TTCAGCAAGGGAAGGAATACAGCAATGCTAAGGCTTTGAGATATGGTCATTTGATGATTATGACCGATCAGGATCATGATGGTTCGCACATTAAAGGACTCTTGATCAAC
TTTATTCATTCTTTCTGGCCTTCTCTCCTAAGAGTGCCGTCGTTTTTGGTTGAATTCATAACGCCTATTGTCAAGGCTACTCATAGGAATGGAACTGTTTTGTCATTCTA
TACCATGCCCGAGTATGAGTCTTGGAGAGAGAGCTTGAGAGGCAATGCAAGTGGCTGGTCAATCAAGTACTATAAGGGGTTGGGAACAAGCACATCAAAAGAAGGAAGAG
AGTACTTTGAACAGCTGACAAAGCACAAGAAAGATTTTATTTGGCAAGATGATAATGATGGGGAGGCCATTGAGCTTGCTTTCAGTAAGAAGAAGATTGAAGATAGAAAG
AATTGGCTCCGTCAATTTGAGCCTGGTACCCATCTAGATCAGACAGGAAGATTGATAAAATACAGTGACTTCGTCAACAAGGAGCTTATATTATTTTCCATGGCTGATTT
ACAAAGGTCTATTCCCTCAATGGTTGATGGCCTTAAGCCTGGCCAAAGGAAGATCCTTTTCTGTTCTTTCAAGAGGAACTTTATCAAAGAAGCAAAGGTTTCTCAATTTT
CCGGTTACGTATCTGAGCACTCTGCTTATCATCATGGTGAGCAGAGTCTTGCTAGTACCATCATTGGAATGGCACAGGACTTTGTCGGCAGTAACAACATTAATCTTCTT
CTACCAAATGGACAGTTTGGCACACGGAACCATGGAGGCAAAGATCATGCAAGTTCTAGGTACATTTACACTAAACTTTCAAATGTCACACGGTTCCTTTTCCCGAAAGA
CGATGACAAACTTCTTAACTACTTAAATGAAGATGGCCAGTCGATTGAACCTACCTGGTATATGCCTATCATACCAACCGTTCTTGTCAATGGAAGTGAAGGAATTGGAA
CTGGGTGGAGTTCCTACGTTCCAAATTATAATCCTAGAGACATCATTAGAAATGTAAGACGTATGTTGGATGGTGAAACGATGTTGCCAATGGATCCCTGGTATAGAGGT
TTTTCAGGAACTATAGAGAAAACTGCCACTAAAGAAGGAGGCACTAGTTACACTGTTAGTGGAATTATAGAGGAAGTCAGTGATACGACGTTGAGAATAATTGAATTGCC
AGTCCGCCGATGGACTAATGACTACAAGGACTTTCTTGACTCTGTCACAAGAGTTGCTTCAAAGCATGACAAAGATAAAGAAAAAGCAGCGAAGGATCCTTTTATTGAGC
AAGCTGATCACCACAGCGATGACAAAATTGTTTCCATTGATGTTCACTTGACGGAGGAAAACATGTTATTGGCCATCCAGGAAGGTTTGAAGAAGAAATTCAAATTAACT
ACAACTGTCAGCACTAGCAACATGCACCTGTTTGATGCGAATGGCGTAATTAAGAAATATGACACCCCAGAACAGATTCTTGAGGAATTCTTCCCCCTTAGACTTGAATT
CTACGAGAAAAGAAAGAGGAATCTTTTGGAAAACCTTGAAATGGAGTTGCTTAAACTGGAAAACAAGGTGAGGTTTATCCTTGCTGTTGTGAATGGAGAAATAATAGTAA
GCAATAGAAGAAAGGTTGATTTGTTCCATGAGCTTCAAGCGAAAGGCTTTACACCCTTTCCAAAGAAGACTAAATCTGCTGAGCCGGAGGTTGCTGGGGCATCTAATGAA
ACAGATGAAGCAGAGGAGAGTCCGGAAGTAGTAAAAGGCGAACGAGTTAGTGATTATGAGTATTTACTAGCTATGGCAATTGGAACCTTGACCATTGAGAAGGTTCAGGA
GCTATGTAATGATAGAGACAAGCTGAAAGGGGAAGTGGACGATCTGAGGAAGGCAACCCCCAAGTCTTTGTGGCTGAATGACCTTGATTCTCTTGAGAAAGAACTTGATG
AGATGGATAGAAATGATGCTCAGGCAATGGAGGTAAGAAAACAGCAGAGAGACAAATCAAATATCGATTTAAAGCCAAAAATCTCTAGAAATGCACCAAAAGCTCCACGT
AACAGTAAGAAAACCAGCAATGCAGAAACTGTCCCAGAAAGTATGGACACAACATCTAGTTCTACAACAACGGAAGTTGCTAATAACCCGGTGGTGAAGCCCAAAGGCAA
AGCAGCTCCAAGAAAAGCTCCCGCTAAGAAGAAACAACCACAGGGTAAAGCTGCAGTTCTTGACGACGAGGACGACGAAGTCCTCGAGCTTAAAGACCGTCTTGCAGCTT
ACAAAATCGAGTCATCTCCTGAACCATCAGAAGTTTCAGTCATGGAAACTGAAGTGCCGCAAGTACAAGCAGCCAAGAAGAAAGAACCCAGCAAGAGAGCAGCTGCAAAG
AAGAAAACTACTGCAAAGTCTGCTCAGATCTCTGCTAGTGATGACGACGAGGACGACTTCGAAATAAAGGAGGTAGCCCCTCCGGCAGCCAAGAAGGGAGGAGGAAGAAA
GGCAGCTGCAAATGCCAAAACAACCAAGCCCCCTGCTGCAGCAGCGAAGCTGGGGCAGAAACTGATAACTCAAATGCTGGAACCAGCAGAGAACTCCGGCATCTCACCGG
AGAAGAAAGTGAGGAAGATCAGAGCATCACCTTTTAACAAGAAAAGTGGCTCTATATTGGGAAGAACAATTGGGGAAGAGGAAGAAGAAGCTGGAAATGAAGATAAAGTA
GTGGGTTCTGCTTCTTCTGAGACCACTGAAGAAGTTGCCAGATTTCCGGCGGCGAGAGGAAGATCACAGAGGGCAAACAGAACACAGGTCAGATATGTGGTTAGTGATTC
AGATAATGATGTTTCTGAGGCTTCGGACTTTGATGAAGAAGCCAGCCTTGATGAAGAAGCCAGCCTTGATGAAGATTGA
mRNA sequenceShow/hide mRNA sequence
ATGGCTGTGGAGAAGAAACGCCCACTGCAGAATAGCAACGCCACCAATGTCGACTCCAATCCGGCAGGTCCAAAGAAAACAATCGAAGAAATGTACCAGAAGAAGTCTCA
GCTCGAGCACATTCTCCTCAGGCCCGATACCTATGTCGGATCTATTGAAAAGCACACCCAAAGCCTCTGGGTTTACGAGAACGACAAAATGGTCCACCGATCCATCTCCT
ACGTGCCTGGTCTTTACAAGATCTTTGATGAAATTTTGGTCAATGCTGCTGATAATAAGCAGAGAGACCCTTCGATGGATTCAGTTAAGGTCAATATTGACGTCGAACAG
AACTGTATCAGTGTGTTCAACAACGGAGATGGAGTTCCGGTTGAAATTCATCAGGAAGAGAAGGTTTATGTGCCTGAGTTGATCTTTGGACATCTCTTGACTAGTAGTAA
CTATGATGACACTGAAAAGAAAACAACTGGTGGACGCAATGGCTATGGTGCGAAACTTACCAATATTTTTTCTACTGAATTTGTGATCGAGACAGCTGATGGAAAACGCC
TAAAGAAGTATAAGCAGGTATTCAATGATAACATGGGGAAAAAATCTGAGCCGATTATAACAAAGTGCAAGGAGGGTGATAATTGGACCAAGGTAACTTTTAAGCCAGAC
TTGGCAAAGTTCAACATGACTCATCTTGAAGATGATGTTGTTGCACTGATGAAGAAGAGAGTGTTGGATTTGGCTGGATGCCTTGGTAAAACCGTGAAGGTTGAGCTGAA
TGGACAAAGGGTCCCTGTTAAATCATTTCAAGATTATGTAGATCTCTACCTCAAATCAGCATCCACATTCCAGACGGAACCTCCAAAAAGGTATCACATTAAGCCTAATG
AGAGATGGGAAATTGTTGTGACCTTAAGTGAGGGCCAGTTCCAGCAGGTCAGCTTTGTGAACGGGATTTCAACTATTAAGGGTGGGACTCATGTTGATTACATCACTAAT
CAAATTGCAAATTATGTGATGACTGTTGTAAATAAGAAGAACAAAAATGCTAACGTGAAGGCCCACAATGTGAAGAGCTATTTGTGGGTTTTTATCAATGCTCTCATTGA
TAATCCATCCTTCGACTCCCAAACCAAGGAAACTTTGACAAAACGTCCAAACAGTTTCGGTTCTGCATGCGAACTTACGCCGGAGTTTTTGAAGAATGTGGCCACAAAAT
CTGGAATTATGGACAGCGTTCTCTCATGGGTTAATTTCAAGCAAAGCAAAGACCTAAAGAAAACAGATGGAGCAAAAACAGAAAAGATTAGTGGTATAGAAAAGTTGGAG
GATGCCAATTGCGCTGGAGGGAAGAACTCAGAAAAATGTACCTTAATTTTGACGGAAGGAGATTCAGCTAAGGCCCTTGCAATGGCTGGGCTCGGTGTAGTAGGGCGAGA
TTTTTATGGTGTATTCCCACTAAGAGGTAAATTGCTCAATGTGAGGGAAGCAAGTAGTAAACAGATCACAGAGAATAAAGAAATTCAATACATCAAGCAAATTCTTGGAC
TTCAGCAAGGGAAGGAATACAGCAATGCTAAGGCTTTGAGATATGGTCATTTGATGATTATGACCGATCAGGATCATGATGGTTCGCACATTAAAGGACTCTTGATCAAC
TTTATTCATTCTTTCTGGCCTTCTCTCCTAAGAGTGCCGTCGTTTTTGGTTGAATTCATAACGCCTATTGTCAAGGCTACTCATAGGAATGGAACTGTTTTGTCATTCTA
TACCATGCCCGAGTATGAGTCTTGGAGAGAGAGCTTGAGAGGCAATGCAAGTGGCTGGTCAATCAAGTACTATAAGGGGTTGGGAACAAGCACATCAAAAGAAGGAAGAG
AGTACTTTGAACAGCTGACAAAGCACAAGAAAGATTTTATTTGGCAAGATGATAATGATGGGGAGGCCATTGAGCTTGCTTTCAGTAAGAAGAAGATTGAAGATAGAAAG
AATTGGCTCCGTCAATTTGAGCCTGGTACCCATCTAGATCAGACAGGAAGATTGATAAAATACAGTGACTTCGTCAACAAGGAGCTTATATTATTTTCCATGGCTGATTT
ACAAAGGTCTATTCCCTCAATGGTTGATGGCCTTAAGCCTGGCCAAAGGAAGATCCTTTTCTGTTCTTTCAAGAGGAACTTTATCAAAGAAGCAAAGGTTTCTCAATTTT
CCGGTTACGTATCTGAGCACTCTGCTTATCATCATGGTGAGCAGAGTCTTGCTAGTACCATCATTGGAATGGCACAGGACTTTGTCGGCAGTAACAACATTAATCTTCTT
CTACCAAATGGACAGTTTGGCACACGGAACCATGGAGGCAAAGATCATGCAAGTTCTAGGTACATTTACACTAAACTTTCAAATGTCACACGGTTCCTTTTCCCGAAAGA
CGATGACAAACTTCTTAACTACTTAAATGAAGATGGCCAGTCGATTGAACCTACCTGGTATATGCCTATCATACCAACCGTTCTTGTCAATGGAAGTGAAGGAATTGGAA
CTGGGTGGAGTTCCTACGTTCCAAATTATAATCCTAGAGACATCATTAGAAATGTAAGACGTATGTTGGATGGTGAAACGATGTTGCCAATGGATCCCTGGTATAGAGGT
TTTTCAGGAACTATAGAGAAAACTGCCACTAAAGAAGGAGGCACTAGTTACACTGTTAGTGGAATTATAGAGGAAGTCAGTGATACGACGTTGAGAATAATTGAATTGCC
AGTCCGCCGATGGACTAATGACTACAAGGACTTTCTTGACTCTGTCACAAGAGTTGCTTCAAAGCATGACAAAGATAAAGAAAAAGCAGCGAAGGATCCTTTTATTGAGC
AAGCTGATCACCACAGCGATGACAAAATTGTTTCCATTGATGTTCACTTGACGGAGGAAAACATGTTATTGGCCATCCAGGAAGGTTTGAAGAAGAAATTCAAATTAACT
ACAACTGTCAGCACTAGCAACATGCACCTGTTTGATGCGAATGGCGTAATTAAGAAATATGACACCCCAGAACAGATTCTTGAGGAATTCTTCCCCCTTAGACTTGAATT
CTACGAGAAAAGAAAGAGGAATCTTTTGGAAAACCTTGAAATGGAGTTGCTTAAACTGGAAAACAAGGTGAGGTTTATCCTTGCTGTTGTGAATGGAGAAATAATAGTAA
GCAATAGAAGAAAGGTTGATTTGTTCCATGAGCTTCAAGCGAAAGGCTTTACACCCTTTCCAAAGAAGACTAAATCTGCTGAGCCGGAGGTTGCTGGGGCATCTAATGAA
ACAGATGAAGCAGAGGAGAGTCCGGAAGTAGTAAAAGGCGAACGAGTTAGTGATTATGAGTATTTACTAGCTATGGCAATTGGAACCTTGACCATTGAGAAGGTTCAGGA
GCTATGTAATGATAGAGACAAGCTGAAAGGGGAAGTGGACGATCTGAGGAAGGCAACCCCCAAGTCTTTGTGGCTGAATGACCTTGATTCTCTTGAGAAAGAACTTGATG
AGATGGATAGAAATGATGCTCAGGCAATGGAGGTAAGAAAACAGCAGAGAGACAAATCAAATATCGATTTAAAGCCAAAAATCTCTAGAAATGCACCAAAAGCTCCACGT
AACAGTAAGAAAACCAGCAATGCAGAAACTGTCCCAGAAAGTATGGACACAACATCTAGTTCTACAACAACGGAAGTTGCTAATAACCCGGTGGTGAAGCCCAAAGGCAA
AGCAGCTCCAAGAAAAGCTCCCGCTAAGAAGAAACAACCACAGGGTAAAGCTGCAGTTCTTGACGACGAGGACGACGAAGTCCTCGAGCTTAAAGACCGTCTTGCAGCTT
ACAAAATCGAGTCATCTCCTGAACCATCAGAAGTTTCAGTCATGGAAACTGAAGTGCCGCAAGTACAAGCAGCCAAGAAGAAAGAACCCAGCAAGAGAGCAGCTGCAAAG
AAGAAAACTACTGCAAAGTCTGCTCAGATCTCTGCTAGTGATGACGACGAGGACGACTTCGAAATAAAGGAGGTAGCCCCTCCGGCAGCCAAGAAGGGAGGAGGAAGAAA
GGCAGCTGCAAATGCCAAAACAACCAAGCCCCCTGCTGCAGCAGCGAAGCTGGGGCAGAAACTGATAACTCAAATGCTGGAACCAGCAGAGAACTCCGGCATCTCACCGG
AGAAGAAAGTGAGGAAGATCAGAGCATCACCTTTTAACAAGAAAAGTGGCTCTATATTGGGAAGAACAATTGGGGAAGAGGAAGAAGAAGCTGGAAATGAAGATAAAGTA
GTGGGTTCTGCTTCTTCTGAGACCACTGAAGAAGTTGCCAGATTTCCGGCGGCGAGAGGAAGATCACAGAGGGCAAACAGAACACAGGTCAGATATGTGGTTAGTGATTC
AGATAATGATGTTTCTGAGGCTTCGGACTTTGATGAAGAAGCCAGCCTTGATGAAGAAGCCAGCCTTGATGAAGATTGA
Protein sequenceShow/hide protein sequence
MAVEKKRPLQNSNATNVDSNPAGPKKTIEEMYQKKSQLEHILLRPDTYVGSIEKHTQSLWVYENDKMVHRSISYVPGLYKIFDEILVNAADNKQRDPSMDSVKVNIDVEQ
NCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFNDNMGKKSEPIITKCKEGDNWTKVTFKPD
LAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASTFQTEPPKRYHIKPNERWEIVVTLSEGQFQQVSFVNGISTIKGGTHVDYITN
QIANYVMTVVNKKNKNANVKAHNVKSYLWVFINALIDNPSFDSQTKETLTKRPNSFGSACELTPEFLKNVATKSGIMDSVLSWVNFKQSKDLKKTDGAKTEKISGIEKLE
DANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQITENKEIQYIKQILGLQQGKEYSNAKALRYGHLMIMTDQDHDGSHIKGLLIN
FIHSFWPSLLRVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWRESLRGNASGWSIKYYKGLGTSTSKEGREYFEQLTKHKKDFIWQDDNDGEAIELAFSKKKIEDRK
NWLRQFEPGTHLDQTGRLIKYSDFVNKELILFSMADLQRSIPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLL
LPNGQFGTRNHGGKDHASSRYIYTKLSNVTRFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDIIRNVRRMLDGETMLPMDPWYRG
FSGTIEKTATKEGGTSYTVSGIIEEVSDTTLRIIELPVRRWTNDYKDFLDSVTRVASKHDKDKEKAAKDPFIEQADHHSDDKIVSIDVHLTEENMLLAIQEGLKKKFKLT
TTVSTSNMHLFDANGVIKKYDTPEQILEEFFPLRLEFYEKRKRNLLENLEMELLKLENKVRFILAVVNGEIIVSNRRKVDLFHELQAKGFTPFPKKTKSAEPEVAGASNE
TDEAEESPEVVKGERVSDYEYLLAMAIGTLTIEKVQELCNDRDKLKGEVDDLRKATPKSLWLNDLDSLEKELDEMDRNDAQAMEVRKQQRDKSNIDLKPKISRNAPKAPR
NSKKTSNAETVPESMDTTSSSTTTEVANNPVVKPKGKAAPRKAPAKKKQPQGKAAVLDDEDDEVLELKDRLAAYKIESSPEPSEVSVMETEVPQVQAAKKKEPSKRAAAK
KKTTAKSAQISASDDDEDDFEIKEVAPPAAKKGGGRKAAANAKTTKPPAAAAKLGQKLITQMLEPAENSGISPEKKVRKIRASPFNKKSGSILGRTIGEEEEEAGNEDKV
VGSASSETTEEVARFPAARGRSQRANRTQVRYVVSDSDNDVSEASDFDEEASLDEEASLDED