CuGenDBv2

Gene ID	HG10019911
Organism	Lagenaria siceraria cv. Hangzhou Gourd (Bottle gourd (Hangzhou Gourd) v1)
Description	DNA topoisomerase
Genome location	Chr04:26818109..26839530
RNA-Seq Expression	HG10019911
Synteny	HG10019911
Gene Ontology terms	GO:0006265 - DNA topological change (biological process) GO:0005634 - nucleus (cellular component) GO:0005694 - chromosome (cellular component) GO:0003677 - DNA binding (molecular function) GO:0008270 - zinc ion binding (molecular function) GO:0003917 - DNA topoisomerase type I activity (molecular function)
InterPro domains	IPR006171 - TOPRIM domain IPR036875 - Zinc finger, CCHC-type superfamily IPR023406 - DNA topoisomerase, type IA, active site IPR023405 - DNA topoisomerase, type IA, core domain IPR013826 - DNA topoisomerase, type IA, central region, subdomain 3 IPR013825 - DNA topoisomerase, type IA, central region, subdomain 2 IPR013824 - DNA topoisomerase, type IA, central region, subdomain 1 IPR013498 - DNA topoisomerase, type IA, zn finger IPR013497 - DNA topoisomerase, type IA, central IPR010666 - Zinc finger, GRF-type IPR003602 - DNA topoisomerase, type IA, DNA-binding domain IPR003601 - DNA topoisomerase, type IA, domain 2 IPR001878 - Zinc finger, CCHC-type IPR000380 - DNA topoisomerase, type IA

Homology

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GenBank top hits

e value

%identity

Alignment

XP_008443145.1 PREDICTED: DNA topoisomerase 3-alpha isoform X1 [Cucumis melo]

0.0e+00

89.26

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Query:  MDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTTANHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLL
        +DIKRTLEQEARR QWLVLWLDCDREGENIAFEVVEVCT  NHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQT+LL
Subjt:  MDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTTANHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLL

Query:  KDAFNIDSVADDKNIVLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMCIQESTATVVNVRRQETLKY
        KDAFNIDSV DD+NIVLSYGPCQFPTLGFVVERYWEIQ+HEPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMC+QESTATVVNVRRQETLKY
Subjt:  KDAFNIDSVADDKNIVLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMCIQESTATVVNVRRQETLKY

Query:  PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHGIVQEQQEHQMWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHP
        PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHGIV+EQQEHQ+WGAYAQRLLDP SGLWRNPSGGGHDDKAHPPIHP
Subjt:  PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHGIVQEQQEHQMWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHP

Query:  TKFSAGERGWSQDHHRLYELVVRHFLACVSQPA------VEHKHAHGLVEFAANEV-ARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGVTRPPP
        TKFSAGERGWSQDHHRLYELVVRHFLACVSQPA      VE   A  L   +   + ARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGVTRPPP
Subjt:  TKFSAGERGWSQDHHRLYELVVRHFLACVSQPA------VEHKHAHGLVEFAANEV-ARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGVTRPPP

Query:  LLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYAMKDANTRFTPTN----LVMSLDFVHHYNLWKPHLRAIMEHEMKAVSEGTKRKDEVLATCLQQMKS
        LLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYA KDANTRFTPT+    LVM  D +  YNLWKPHLRAIMEHEMKAVSEGTKRKDEVLA+CLQQMK+
Subjt:  LLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYAMKDANTRFTPTN----LVMSLDFVHHYNLWKPHLRAIMEHEMKAVSEGTKRKDEVLATCLQQMKS

Query:  CFLDARVNKQKLLEAMEVFFERSNGTGGDENRAVGEVVQRCGLCQDSDMVLKRNRDGNYMVGCMAFPQCRNVVWLPGSIAEAAVTSDCCNSCTPGPVYLI
        CFLDARVNKQKLLEAMEVFFERSNG+GGDENRAVGEVVQ CGLCQ+SDMVLKRNRDGNYMVGC+AFPQCRNVVWLPGSIAEA VTSD C  CTPGPVYLI
Subjt:  CFLDARVNKQKLLEAMEVFFERSNGTGGDENRAVGEVVQRCGLCQDSDMVLKRNRDGNYMVGCMAFPQCRNVVWLPGSIAEAAVTSDCCNSCTPGPVYLI

Query:  QFKFRQLEIPPNYNANHLGCIGGCDDILRQLTEICGTGSRVSGMYLLCTRGRGTSSSSLQRDNTGQNVCIFCQQVGHSSNGCPSQVVGSRSARRRQSGDS
        QFKFRQLEIPPNYNANHLGC+GGCDDILRQLTEICGTGSRVS       RGRGTSSS++QRDN GQ+VCIFCQQVGHSSN CPSQ VGS SAR RQSG+S
Subjt:  QFKFRQLEIPPNYNANHLGCIGGCDDILRQLTEICGTGSRVSGMYLLCTRGRGTSSSSLQRDNTGQNVCIFCQQVGHSSNGCPSQVVGSRSARRRQSGDS

Query:  SVSCSNCGTPCVLRTANTTNNRGRKFYKCQSQECNFFVWEDNVDNGNGGNSVPRSNIRSSGSAASNPNPGRNTGHGRGRSR----------GQIAATFVS
        SVSCS+CGTPCVLRTANTTNNRGRKFYKCQSQECNFFVWEDNVDN NGGNS  RSN+RSSGSA SNPNPG+NTG GRGRSR          GQIAATFVS
Subjt:  SVSCSNCGTPCVLRTANTTNNRGRKFYKCQSQECNFFVWEDNVDNGNGGNSVPRSNIRSSGSAASNPNPGRNTGHGRGRSR----------GQIAATFVS

Query:  ATGEPISDRRCFVCGDPSHFANVCPNRGA
        ATGEPISDRRCFVCGDPSHFANVCPNRGA
Subjt:  ATGEPISDRRCFVCGDPSHFANVCPNRGA

XP_011652135.2 DNA topoisomerase 3-alpha isoform X1 [Cucumis sativus]

0.0e+00

88.81

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Query:  MDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTTANHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLL
        +DIKRTLEQE+RR QWLVLWLDCDREGENIAFEVVEVCT  NHHLNIKRAHFSALIERDIH+AVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQT+LL
Subjt:  MDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTTANHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLL

Query:  KDAFNIDSVADDKNIVLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMCIQESTATVVNVRRQETLKY
        KDAFNIDSV DD+NIVLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMC+QESTATVVNVRRQETLKY
Subjt:  KDAFNIDSVADDKNIVLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMCIQESTATVVNVRRQETLKY

Query:  PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHGIVQEQQEHQMWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHP
        PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHGIV+EQQEHQ+WGAYAQRLLDP S LWRNPSGGGHDDKAHPPIHP
Subjt:  PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHGIVQEQQEHQMWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHP

Query:  TKFSAGERGWSQDHHRLYELVVRHFLACVSQPA------VEHKHAHGLVEFAANEV-ARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGVTRPPP
        TKFSAGERGWSQDHHRLYELVVRHFLACVSQPA      VE   A  L   +   + ARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGVTRPPP
Subjt:  TKFSAGERGWSQDHHRLYELVVRHFLACVSQPA------VEHKHAHGLVEFAANEV-ARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGVTRPPP

Query:  LLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYAMKDANTRFTPTN----LVMSLDFVHHYNLWKPHLRAIMEHEMKAVSEGTKRKDEVLATCLQQMKS
        LLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYA KDANTRFTPTN    LVM  D +  YNLWKP+LRAIMEHEMKAVSEGTKRKDEVLA+CLQQMK+
Subjt:  LLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYAMKDANTRFTPTN----LVMSLDFVHHYNLWKPHLRAIMEHEMKAVSEGTKRKDEVLATCLQQMKS

Query:  CFLDARVNKQKLLEAMEVFFERSNGTGGDENRAVGEVVQRCGLCQDSDMVLKRNRDGNYMVGCMAFPQCRNVVWLPGSIAEAAVTSDCCNSCTPGPVYLI
        CFLDARVNKQKLLEAMEVFFERSNG+GGDENRAVGEVVQ CGLCQDSDMVLKRNRDGNYMVGC+AFPQCRNVVWLPGSIAEA VTSD C  CTPGPVYLI
Subjt:  CFLDARVNKQKLLEAMEVFFERSNGTGGDENRAVGEVVQRCGLCQDSDMVLKRNRDGNYMVGCMAFPQCRNVVWLPGSIAEAAVTSDCCNSCTPGPVYLI

Query:  QFKFRQLEIPPNYNANHLGCIGGCDDILRQLTEICGTGSRVSGMYLLCTRGRGTSSSSLQRDNTGQNVCIFCQQVGHSSNGCPSQVVGSRSARRRQSGDS
        QFKFRQLEIPPNYNANHLGC+GGCDDILRQLTEICGTGSRVS       RGRGTSSS++QRDN GQ+VCIFCQQVGHSSN CPSQ VGSRSA+RRQSG+S
Subjt:  QFKFRQLEIPPNYNANHLGCIGGCDDILRQLTEICGTGSRVSGMYLLCTRGRGTSSSSLQRDNTGQNVCIFCQQVGHSSNGCPSQVVGSRSARRRQSGDS

Query:  SVSCSNCGTPCVLRTANTTNNRGRKFYKCQSQECNFFVWEDNVDNGNGGNSVPRSNIRSSGSAASNPNPGRNTGHGRGRSR------------GQIAATF
        SVSCS+CG+PCVLRTANT NNRGRKFYKCQSQECNFFVWEDNVDNGNGGNSV RSN+RSSGSA SN NPG+NTG GRGR R            GQIAATF
Subjt:  SVSCSNCGTPCVLRTANTTNNRGRKFYKCQSQECNFFVWEDNVDNGNGGNSVPRSNIRSSGSAASNPNPGRNTGHGRGRSR------------GQIAATF

Query:  VSATGEPISDRRCFVCGDPSHFANVCPNRGA
        VSATGEPISDRRCFVCGDPSHFANVCPNRGA
Subjt:  VSATGEPISDRRCFVCGDPSHFANVCPNRGA

XP_023526238.1 DNA topoisomerase 3-alpha isoform X1 [Cucurbita pepo subsp. pepo]

0.0e+00

88.3

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Query:  MDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTTANHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLL
        MDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTT N HLNIKRAHFSALIERDIHEAVQNLVQPNK+FADAVDARQEIDLRIGASFTRFQTMLL
Subjt:  MDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTTANHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLL

Query:  KDAFNIDSVADDKNIVLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMCIQESTATVVNVRRQETLKY
        KDAFNIDSV DD+N+VLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNS DGISTFSWTRGNLFDYTCAVV YEMC++ESTATVVNV+RQETLKY
Subjt:  KDAFNIDSVADDKNIVLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMCIQESTATVVNVRRQETLKY

Query:  PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHGIVQEQQEHQMWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHP
        PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHGIVQEQQEHQ+WGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHP
Subjt:  PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHGIVQEQQEHQMWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHP

Query:  TKFSAGERGWSQDHHRLYELVVRHFLACVSQPA------VEHKHAHGLVEFAANEV-ARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGVTRPPP
        TKFSAGERGWSQDHHRLYELVVRHFLACVSQPA      VE   A  L   +   + ARNYLDVYRFESWGGSTIPTY SGQQFVPTTLTLDSGVTRPPP
Subjt:  TKFSAGERGWSQDHHRLYELVVRHFLACVSQPA------VEHKHAHGLVEFAANEV-ARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGVTRPPP

Query:  LLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYAMKDANTRFTPTN----LVMSLDFVHHYNLWKPHLRAIMEHEMKAVSEGTKRKDEVLATCLQQMKS
        LLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYA KDANTRFTPTN    LVM  D +  Y LWKPHLRA+MEHEMKAVSEG KRKDEVLATCLQQMKS
Subjt:  LLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYAMKDANTRFTPTN----LVMSLDFVHHYNLWKPHLRAIMEHEMKAVSEGTKRKDEVLATCLQQMKS

Query:  CFLDARVNKQKLLEAMEVFFERSNGTGGDENRAVGEVVQRCGLCQDSDMVLKRNRDGNYMVGCMAFPQCRNVVWLPGSIAEAAVTSDCCNSCTPGPVYLI
        CFLDAR NKQKL EAMEVFFERSNG+GGDEN AVGEVVQRC LCQDSDMVLKRNRDGNYMVGC+ FPQCRNVVWLPGSIAEAAVTS+ CNSCTPGPVYLI
Subjt:  CFLDARVNKQKLLEAMEVFFERSNGTGGDENRAVGEVVQRCGLCQDSDMVLKRNRDGNYMVGCMAFPQCRNVVWLPGSIAEAAVTSDCCNSCTPGPVYLI

Query:  QFKFRQLEIPPNYNANHLGCIGGCDDILRQLTEICGTGSRVSGMYLLCTRGRGTSSSSLQRDNTGQNVCIFCQQVGHSSNGCPSQVVGSRSARRRQSGDS
        QFKFRQLEIPPNYN NHLGCIGGCDDILRQLTEICGTGSR+S       RGRGTSSSS+QR NT  +VC+FCQQ+ HSSN CPSQVVGSRSARRRQ+G+S
Subjt:  QFKFRQLEIPPNYNANHLGCIGGCDDILRQLTEICGTGSRVSGMYLLCTRGRGTSSSSLQRDNTGQNVCIFCQQVGHSSNGCPSQVVGSRSARRRQSGDS

Query:  SVSCSNCGTPCVLRTANTTNNRGRKFYKCQSQECNFFVWEDNVDNGNGGNSVPRSNIRSSGSAASNPNPGRNTGHGRGR----------SRGQIAATFVS
        S SCSNCGTPCVLRTANTTNNRGRKFYKCQSQECNFF WED+VD+ NGGNS  RSNIRSSGSAASN NPGRNTG GRGR           +GQIAATFVS
Subjt:  SVSCSNCGTPCVLRTANTTNNRGRKFYKCQSQECNFFVWEDNVDNGNGGNSVPRSNIRSSGSAASNPNPGRNTGHGRGR----------SRGQIAATFVS

Query:  ATGEPISDRRCFVCGDPSHFANVCPNRGA
        ATGEPISDRRCFVCGDPSHFANVCPNRGA
Subjt:  ATGEPISDRRCFVCGDPSHFANVCPNRGA

XP_038904101.1 DNA topoisomerase 3-alpha isoform X1 [Benincasa hispida]

0.0e+00

91.45

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Query:  MDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTTANHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLL
        MDIKRTLEQEARRCQWL+LWLDCDREGENIAFEVVEVCT  N HLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLL
Subjt:  MDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTTANHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLL

Query:  KDAFNIDSVADDKNIVLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMCIQESTATVVNVRRQETLKY
        KDAFNIDSV DD+NIVLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNS DGISTFSWTRGNLFDYTCAVVFYEMC+QE TATVVNVRRQETLKY
Subjt:  KDAFNIDSVADDKNIVLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMCIQESTATVVNVRRQETLKY

Query:  PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHGIVQEQQEHQMWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHP
        PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHGIVQEQQEHQ+WGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHP
Subjt:  PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHGIVQEQQEHQMWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHP

Query:  TKFSAGERGWSQDHHRLYELVVRHFLACVSQPA------VEHKHAHGLVEFAANEV-ARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGVTRPPP
        TKFSAGERGWSQDHHRLYELVVRHFLACVSQPA      VE   A  L   +   + ARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGVTRPPP
Subjt:  TKFSAGERGWSQDHHRLYELVVRHFLACVSQPA------VEHKHAHGLVEFAANEV-ARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGVTRPPP

Query:  LLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYAMKDANTRFTPTN----LVMSLDFVHHYNLWKPHLRAIMEHEMKAVSEGTKRKDEVLATCLQQMKS
        LLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYA KDANTRFTPTN    LVM  D +  YNLWKPHLRAIMEHEMKAVSEGTKRKDEVLATCLQQMKS
Subjt:  LLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYAMKDANTRFTPTN----LVMSLDFVHHYNLWKPHLRAIMEHEMKAVSEGTKRKDEVLATCLQQMKS

Query:  CFLDARVNKQKLLEAMEVFFERSNGTGGDENRAVGEVVQRCGLCQDSDMVLKRNRDGNYMVGCMAFPQCRNVVWLPGSIAEAAVTSDCCNSCTPGPVYLI
        CFLDARVNKQKLLEAMEVFFERSNG+GGDENRAVGEVVQRCGLCQDS+MVLKRNRDGNYMVGC+AFPQCRNVVWLPGSIAEAAVTSDCCN CTPGPVYLI
Subjt:  CFLDARVNKQKLLEAMEVFFERSNGTGGDENRAVGEVVQRCGLCQDSDMVLKRNRDGNYMVGCMAFPQCRNVVWLPGSIAEAAVTSDCCNSCTPGPVYLI

Query:  QFKFRQLEIPPNYNANHLGCIGGCDDILRQLTEICGTGSRVSGMYLLCTRGRGTSSSSLQRDNTGQNVCIFCQQVGHSSNGCPSQVVGSRSARRRQSGDS
        QFKFRQLEIPPNYNANHLGCIGGCDDILRQLTEICGTGSRVS       RGRGTSSSS+QRDNT Q+VCIFCQQVGHSSN CPSQVVGSRSA RRQSG+ 
Subjt:  QFKFRQLEIPPNYNANHLGCIGGCDDILRQLTEICGTGSRVSGMYLLCTRGRGTSSSSLQRDNTGQNVCIFCQQVGHSSNGCPSQVVGSRSARRRQSGDS

Query:  SVSCSNCGTPCVLRTANTTNNRGRKFYKCQSQECNFFVWEDNVDNGNGGNSVPRSNIRSSGSAASNPNPGRNTGHGRGRSRGQIAATFVSATGEPISDRR
        SVSCSNCGTPCVLRTANTTNNRGRKFYKCQSQECNFFVWEDNVDN NGGNS  RSNIR+SGSAA NPNPGRNTG GRGR   +IAATFVSATGEPISDRR
Subjt:  SVSCSNCGTPCVLRTANTTNNRGRKFYKCQSQECNFFVWEDNVDNGNGGNSVPRSNIRSSGSAASNPNPGRNTGHGRGRSRGQIAATFVSATGEPISDRR

Query:  CFVCGDPSHFANVCPNRGA
        CFVCGD SHFANVCPNRGA
Subjt:  CFVCGDPSHFANVCPNRGA

XP_038904103.1 DNA topoisomerase 3-alpha isoform X3 [Benincasa hispida]

0.0e+00

91.45

Show/hide

Query:  MDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTTANHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLL
        MDIKRTLEQEARRCQWL+LWLDCDREGENIAFEVVEVCT  N HLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLL
Subjt:  MDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTTANHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLL

Query:  KDAFNIDSVADDKNIVLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMCIQESTATVVNVRRQETLKY
        KDAFNIDSV DD+NIVLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNS DGISTFSWTRGNLFDYTCAVVFYEMC+QE TATVVNVRRQETLKY
Subjt:  KDAFNIDSVADDKNIVLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMCIQESTATVVNVRRQETLKY

Query:  PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHGIVQEQQEHQMWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHP
        PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHGIVQEQQEHQ+WGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHP
Subjt:  PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHGIVQEQQEHQMWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHP

Query:  TKFSAGERGWSQDHHRLYELVVRHFLACVSQPA------VEHKHAHGLVEFAANEV-ARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGVTRPPP
        TKFSAGERGWSQDHHRLYELVVRHFLACVSQPA      VE   A  L   +   + ARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGVTRPPP
Subjt:  TKFSAGERGWSQDHHRLYELVVRHFLACVSQPA------VEHKHAHGLVEFAANEV-ARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGVTRPPP

Query:  LLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYAMKDANTRFTPTN----LVMSLDFVHHYNLWKPHLRAIMEHEMKAVSEGTKRKDEVLATCLQQMKS
        LLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYA KDANTRFTPTN    LVM  D +  YNLWKPHLRAIMEHEMKAVSEGTKRKDEVLATCLQQMKS
Subjt:  LLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYAMKDANTRFTPTN----LVMSLDFVHHYNLWKPHLRAIMEHEMKAVSEGTKRKDEVLATCLQQMKS

Query:  CFLDARVNKQKLLEAMEVFFERSNGTGGDENRAVGEVVQRCGLCQDSDMVLKRNRDGNYMVGCMAFPQCRNVVWLPGSIAEAAVTSDCCNSCTPGPVYLI
        CFLDARVNKQKLLEAMEVFFERSNG+GGDENRAVGEVVQRCGLCQDS+MVLKRNRDGNYMVGC+AFPQCRNVVWLPGSIAEAAVTSDCCN CTPGPVYLI
Subjt:  CFLDARVNKQKLLEAMEVFFERSNGTGGDENRAVGEVVQRCGLCQDSDMVLKRNRDGNYMVGCMAFPQCRNVVWLPGSIAEAAVTSDCCNSCTPGPVYLI

Query:  QFKFRQLEIPPNYNANHLGCIGGCDDILRQLTEICGTGSRVSGMYLLCTRGRGTSSSSLQRDNTGQNVCIFCQQVGHSSNGCPSQVVGSRSARRRQSGDS
        QFKFRQLEIPPNYNANHLGCIGGCDDILRQLTEICGTGSRVS       RGRGTSSSS+QRDNT Q+VCIFCQQVGHSSN CPSQVVGSRSA RRQSG+ 
Subjt:  QFKFRQLEIPPNYNANHLGCIGGCDDILRQLTEICGTGSRVSGMYLLCTRGRGTSSSSLQRDNTGQNVCIFCQQVGHSSNGCPSQVVGSRSARRRQSGDS

Query:  SVSCSNCGTPCVLRTANTTNNRGRKFYKCQSQECNFFVWEDNVDNGNGGNSVPRSNIRSSGSAASNPNPGRNTGHGRGRSRGQIAATFVSATGEPISDRR
        SVSCSNCGTPCVLRTANTTNNRGRKFYKCQSQECNFFVWEDNVDN NGGNS  RSNIR+SGSAA NPNPGRNTG GRGR   +IAATFVSATGEPISDRR
Subjt:  SVSCSNCGTPCVLRTANTTNNRGRKFYKCQSQECNFFVWEDNVDNGNGGNSVPRSNIRSSGSAASNPNPGRNTGHGRGRSRGQIAATFVSATGEPISDRR

Query:  CFVCGDPSHFANVCPNRGA
        CFVCGD SHFANVCPNRGA
Subjt:  CFVCGDPSHFANVCPNRGA

TrEMBL top hits

e value

%identity

Alignment

A0A0A0LBG7 DNA topoisomerase

0.0e+00

88.69

Show/hide

Query:  MDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTTANHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLL
        +DIKRTLEQE+RR QWLVLWLDCDREGENIAFEVVEVCT  NHHLNIKRAHFSALIERDIH+AVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQT+LL
Subjt:  MDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTTANHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLL

Query:  KDAFNIDSVADDKNIVLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMCIQESTATVVNVRRQETLKY
        KDAFNIDSV DD+NIVLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMC+QESTATVVNVRRQETLKY
Subjt:  KDAFNIDSVADDKNIVLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMCIQESTATVVNVRRQETLKY

Query:  PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHGIVQEQQEHQMWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHP
        PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHGIV+EQQEHQ+WGAYAQRLLDP S LWRNPSGGGHDDKAHPPIHP
Subjt:  PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHGIVQEQQEHQMWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHP

Query:  TKFSAGERGWSQDHHRLYELVVRHFLACVSQPA------VEHKHAHGLVEFAANEV-ARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGVTRPPP
        TKFSAGERGWSQDHHRLYELVVRHFLACVSQPA      VE   A  L   +   + ARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGVTRPPP
Subjt:  TKFSAGERGWSQDHHRLYELVVRHFLACVSQPA------VEHKHAHGLVEFAANEV-ARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGVTRPPP

Query:  LLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYAMKDANTRFTPTN----LVMSLDFVHHYNLWKPHLRAIMEHEMKAVSEGTKRKDEVLATCLQQMKS
        LLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYA KDANTRFTPTN    LVM  D +  YNLWKP+LRAIMEHEMKAVSEGTKRKDEVLA+CLQQMK+
Subjt:  LLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYAMKDANTRFTPTN----LVMSLDFVHHYNLWKPHLRAIMEHEMKAVSEGTKRKDEVLATCLQQMKS

Query:  CFLDARVNKQKLLEAMEVFFERSNGTGGDENRAVGEVVQRCGLCQDSDMVLKRNRDGNYMVGCMAFPQCRNVVWLPGSIAEAAVTSDCCNSCTPGPVYLI
        CFLDARVNKQKLLEAMEVFFERSNG+GGDENRAVGEVVQ CGLCQDSDMVLKRNRDGNYMVGC+ FPQCRNVVWLPGSIAEA VTSD C  CTPGPVYLI
Subjt:  CFLDARVNKQKLLEAMEVFFERSNGTGGDENRAVGEVVQRCGLCQDSDMVLKRNRDGNYMVGCMAFPQCRNVVWLPGSIAEAAVTSDCCNSCTPGPVYLI

Query:  QFKFRQLEIPPNYNANHLGCIGGCDDILRQLTEICGTGSRVSGMYLLCTRGRGTSSSSLQRDNTGQNVCIFCQQVGHSSNGCPSQVVGSRSARRRQSGDS
        QFKFRQLEIPPNYNANHLGC+GGCDDILRQLTEICGTGSRVS       RGRGTSSS++QRDN GQ+VCIFCQQVGHSSN CPSQ VGSRSA+RRQSG+S
Subjt:  QFKFRQLEIPPNYNANHLGCIGGCDDILRQLTEICGTGSRVSGMYLLCTRGRGTSSSSLQRDNTGQNVCIFCQQVGHSSNGCPSQVVGSRSARRRQSGDS

Query:  SVSCSNCGTPCVLRTANTTNNRGRKFYKCQSQECNFFVWEDNVDNGNGGNSVPRSNIRSSGSAASNPNPGRNTGHGRGRSR------------GQIAATF
        SVSCS+CG+PCVLRTANT NNRGRKFYKCQSQECNFFVWEDNVDNGNGGNSV RSN+RSSGSA SN NPG+NTG GRGR R            GQIAATF
Subjt:  SVSCSNCGTPCVLRTANTTNNRGRKFYKCQSQECNFFVWEDNVDNGNGGNSVPRSNIRSSGSAASNPNPGRNTGHGRGRSR------------GQIAATF

Query:  VSATGEPISDRRCFVCGDPSHFANVCPNRGA
        VSATGEPISDRRCFVCGDPSHFANVCPNRGA
Subjt:  VSATGEPISDRRCFVCGDPSHFANVCPNRGA

A0A1S3B7B9 DNA topoisomerase

0.0e+00

89.26

Show/hide

Query:  MDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTTANHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLL
        +DIKRTLEQEARR QWLVLWLDCDREGENIAFEVVEVCT  NHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQT+LL
Subjt:  MDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTTANHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLL

Query:  KDAFNIDSVADDKNIVLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMCIQESTATVVNVRRQETLKY
        KDAFNIDSV DD+NIVLSYGPCQFPTLGFVVERYWEIQ+HEPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMC+QESTATVVNVRRQETLKY
Subjt:  KDAFNIDSVADDKNIVLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMCIQESTATVVNVRRQETLKY

Query:  PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHGIVQEQQEHQMWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHP
        PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHGIV+EQQEHQ+WGAYAQRLLDP SGLWRNPSGGGHDDKAHPPIHP
Subjt:  PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHGIVQEQQEHQMWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHP

Query:  TKFSAGERGWSQDHHRLYELVVRHFLACVSQPA------VEHKHAHGLVEFAANEV-ARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGVTRPPP
        TKFSAGERGWSQDHHRLYELVVRHFLACVSQPA      VE   A  L   +   + ARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGVTRPPP
Subjt:  TKFSAGERGWSQDHHRLYELVVRHFLACVSQPA------VEHKHAHGLVEFAANEV-ARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGVTRPPP

Query:  LLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYAMKDANTRFTPTN----LVMSLDFVHHYNLWKPHLRAIMEHEMKAVSEGTKRKDEVLATCLQQMKS
        LLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYA KDANTRFTPT+    LVM  D +  YNLWKPHLRAIMEHEMKAVSEGTKRKDEVLA+CLQQMK+
Subjt:  LLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYAMKDANTRFTPTN----LVMSLDFVHHYNLWKPHLRAIMEHEMKAVSEGTKRKDEVLATCLQQMKS

Query:  CFLDARVNKQKLLEAMEVFFERSNGTGGDENRAVGEVVQRCGLCQDSDMVLKRNRDGNYMVGCMAFPQCRNVVWLPGSIAEAAVTSDCCNSCTPGPVYLI
        CFLDARVNKQKLLEAMEVFFERSNG+GGDENRAVGEVVQ CGLCQ+SDMVLKRNRDGNYMVGC+AFPQCRNVVWLPGSIAEA VTSD C  CTPGPVYLI
Subjt:  CFLDARVNKQKLLEAMEVFFERSNGTGGDENRAVGEVVQRCGLCQDSDMVLKRNRDGNYMVGCMAFPQCRNVVWLPGSIAEAAVTSDCCNSCTPGPVYLI

Query:  QFKFRQLEIPPNYNANHLGCIGGCDDILRQLTEICGTGSRVSGMYLLCTRGRGTSSSSLQRDNTGQNVCIFCQQVGHSSNGCPSQVVGSRSARRRQSGDS
        QFKFRQLEIPPNYNANHLGC+GGCDDILRQLTEICGTGSRVS       RGRGTSSS++QRDN GQ+VCIFCQQVGHSSN CPSQ VGS SAR RQSG+S
Subjt:  QFKFRQLEIPPNYNANHLGCIGGCDDILRQLTEICGTGSRVSGMYLLCTRGRGTSSSSLQRDNTGQNVCIFCQQVGHSSNGCPSQVVGSRSARRRQSGDS

Query:  SVSCSNCGTPCVLRTANTTNNRGRKFYKCQSQECNFFVWEDNVDNGNGGNSVPRSNIRSSGSAASNPNPGRNTGHGRGRSR----------GQIAATFVS
        SVSCS+CGTPCVLRTANTTNNRGRKFYKCQSQECNFFVWEDNVDN NGGNS  RSN+RSSGSA SNPNPG+NTG GRGRSR          GQIAATFVS
Subjt:  SVSCSNCGTPCVLRTANTTNNRGRKFYKCQSQECNFFVWEDNVDNGNGGNSVPRSNIRSSGSAASNPNPGRNTGHGRGRSR----------GQIAATFVS

Query:  ATGEPISDRRCFVCGDPSHFANVCPNRGA
        ATGEPISDRRCFVCGDPSHFANVCPNRGA
Subjt:  ATGEPISDRRCFVCGDPSHFANVCPNRGA

A0A6J1DNA0 DNA topoisomerase

0.0e+00

88.17

Show/hide

Query:  MDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTTANHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLL
        MDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVV+VCT  N HL IKRAHFSALIERDIHEAVQNLVQPN+WFADAVDARQEIDLRIGASFTRFQTMLL
Subjt:  MDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTTANHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLL

Query:  KDAFNIDSVADDKNIVLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMCIQESTATVVNVRRQETLKY
        KDAF IDSV DDKN++LSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFSWTRG+LFDYTCAVV YEMC+QESTATVVNVRRQETLKY
Subjt:  KDAFNIDSVADDKNIVLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMCIQESTATVVNVRRQETLKY

Query:  PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHGIVQEQQEHQMWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHP
        PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETD FSQRTDLH IVQEQQ HQ+WGAYAQRLLDPGSGLWRNPS GGHDDKAHPPIHP
Subjt:  PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHGIVQEQQEHQMWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHP

Query:  TKFSAGERGWSQDHHRLYELVVRHFLACVSQPA------VEHKHAHGLVEFAANEV-ARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGVTRPPP
        TKFSAGERGWSQDHH+LYELVVRHFLACVSQPA      VE   A  L   +   + ARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGVTRPPP
Subjt:  TKFSAGERGWSQDHHRLYELVVRHFLACVSQPA------VEHKHAHGLVEFAANEV-ARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGVTRPPP

Query:  LLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYAMKDANTRFTPTN----LVMSLDFVHHYNLWKPHLRAIMEHEMKAVSEGTKRKDEVLATCLQQMKS
        LLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYA KD NTRFTPTN    LVM  D +  Y LWKP+LRA+MEHEMKAVSEGTKRK EVLA  LQQMK+
Subjt:  LLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYAMKDANTRFTPTN----LVMSLDFVHHYNLWKPHLRAIMEHEMKAVSEGTKRKDEVLATCLQQMKS

Query:  CFLDARVNKQKLLEAMEVFFERSNGTGGDENRAVGEVVQRCGLCQDSDMVLKRNRDGNYMVGCMAFPQCRNVVWLPGSIAEAAVTSDCCNSCTPGPVYLI
        CFLDAR+NK KLLEAMEVFFERSNG+GGDE+  VG VV+RCGLCQDSDMVLKRNRDGNYMVGC+ FPQCRNVVWLPGSIAEAAVT DCCNSCTPGPVYLI
Subjt:  CFLDARVNKQKLLEAMEVFFERSNGTGGDENRAVGEVVQRCGLCQDSDMVLKRNRDGNYMVGCMAFPQCRNVVWLPGSIAEAAVTSDCCNSCTPGPVYLI

Query:  QFKFRQLEIPPNYNANHLGCIGGCDDILRQLTEICGTGSRVSGMYLLCTRGRG-TSSSSLQRDNTGQNVCIFCQQVGHSSNGCPSQVVGSRSARRRQSGD
        QFKFR LEIPPNYNANHLGCIGGCDDILRQLTEICGTGSR+SG      RGRG TSSSS QR NTGQ VCI CQQVGHSSN CPSQVVGSRSARRRQSG+
Subjt:  QFKFRQLEIPPNYNANHLGCIGGCDDILRQLTEICGTGSRVSGMYLLCTRGRG-TSSSSLQRDNTGQNVCIFCQQVGHSSNGCPSQVVGSRSARRRQSGD

Query:  SSVSCSNCGTPCVLRTANTTNNRGRKFYKCQSQECNFFVWEDNVDNGNGGNSVPRSNIRSSGSAASNPNPGRNTGHGRGRSRGQIAATFVSATGEPISDR
        SSVSCSNCGTPCVLRTANT NNRGRKFY CQSQ+CNFFVWEDN+D+GNGGNS PRSNIR S S ASNPNPG+NTGHGRGR RG IA TFVSATGEPISDR
Subjt:  SSVSCSNCGTPCVLRTANTTNNRGRKFYKCQSQECNFFVWEDNVDNGNGGNSVPRSNIRSSGSAASNPNPGRNTGHGRGRSRGQIAATFVSATGEPISDR

Query:  RCFVCGDPSHFANVCPNRGA
        RCFVCGDPSHFANVCPNRGA
Subjt:  RCFVCGDPSHFANVCPNRGA

A0A6J1F0T9 DNA topoisomerase

0.0e+00

88.58

Show/hide

Query:  MDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTTANHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLL
        MDIKRTLEQEA RCQWLVLWLDCDREGENIAFEVVEVCT  N HLNIKRAHFSALIERDIHEAVQNLVQPNK++ADAVDARQEIDLRIGASFTRFQTMLL
Subjt:  MDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTTANHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLL

Query:  KDAFNIDSVADDKNIVLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMCIQESTATVVNVRRQETLKY
        KDAFNIDSV DD+N+VLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNS DGISTFSWTRGNLFDYTCAVV YEMC++ESTATVVNV+RQETLKY
Subjt:  KDAFNIDSVADDKNIVLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMCIQESTATVVNVRRQETLKY

Query:  PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHGIVQEQQEHQMWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHP
        PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHGIVQEQQEHQ+WGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHP
Subjt:  PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHGIVQEQQEHQMWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHP

Query:  TKFSAGERGWSQDHHRLYELVVRHFLACVSQPA------VEHKHAHGLVEFAANEV-ARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGVTRPPP
        TKFSAGERGWSQDHHRLYELVVRHFLACVSQPA      VE   A  L   +   + ARNYLDVYRFESWGGSTIPTY SGQQFVPTTLTLDSGVTRPPP
Subjt:  TKFSAGERGWSQDHHRLYELVVRHFLACVSQPA------VEHKHAHGLVEFAANEV-ARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGVTRPPP

Query:  LLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYAMKDANTRFTPTN----LVMSLDFVHHYNLWKPHLRAIMEHEMKAVSEGTKRKDEVLATCLQQMKS
        LLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYA KDANTRFTPTN    LVM  D +  Y LWKPHLRA+MEHEMKAVSEG KRKDEVLATCLQQMKS
Subjt:  LLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYAMKDANTRFTPTN----LVMSLDFVHHYNLWKPHLRAIMEHEMKAVSEGTKRKDEVLATCLQQMKS

Query:  CFLDARVNKQKLLEAMEVFFERSNGTGGDENRAVGEVVQRCGLCQDSDMVLKRNRDGNYMVGCMAFPQCRNVVWLPGSIAEAAVTSDCCNSCTPGPVYLI
        CFLDAR NKQKL EAMEVFFERSNG+GGDEN AVGEVVQRC LCQDSDMVLKRNRDGNYMVGC+ FPQCRNVVWLPGSIAEAAVTS+ CNSCTPGPVYLI
Subjt:  CFLDARVNKQKLLEAMEVFFERSNGTGGDENRAVGEVVQRCGLCQDSDMVLKRNRDGNYMVGCMAFPQCRNVVWLPGSIAEAAVTSDCCNSCTPGPVYLI

Query:  QFKFRQLEIPPNYNANHLGCIGGCDDILRQLTEICGTGSRVSGMYLLCTRGRGTSSSSLQRDNTGQNVCIFCQQVGHSSNGCPSQVVGSRSARRRQSGDS
        QFKFRQLEIPPNYN NHLGCIGGCDDILRQLTEICGTGSR+S       RGRGTSSSS+QR NT Q+VC+FCQQ+ HSSN CPSQVVGSRSARRRQ+G+S
Subjt:  QFKFRQLEIPPNYNANHLGCIGGCDDILRQLTEICGTGSRVSGMYLLCTRGRGTSSSSLQRDNTGQNVCIFCQQVGHSSNGCPSQVVGSRSARRRQSGDS

Query:  SVSCSNCGTPCVLRTANTTNNRGRKFYKCQSQECNFFVWEDNVDNGNGGNSVPRSNIRSSGSAASNPNPGRNTGHGRGR----SRGQIAATFVSATGEPI
        S SCSNCGTPCVLRTANTTNNRGRKFYKCQSQECNFF WED+VD+ NGGNS  RSNIRSSGSAASN NPGRNTG GRGR     +GQIAATFVSA GEPI
Subjt:  SVSCSNCGTPCVLRTANTTNNRGRKFYKCQSQECNFFVWEDNVDNGNGGNSVPRSNIRSSGSAASNPNPGRNTGHGRGR----SRGQIAATFVSATGEPI

Query:  SDRRCFVCGDPSHFANVCPNRGA
        SDRRCFVCGDPSHFANVCPNRGA
Subjt:  SDRRCFVCGDPSHFANVCPNRGA

A0A6J1IXM8 DNA topoisomerase

0.0e+00

88.7

Show/hide

Query:  MDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTTANHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLL
        MDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTT N HLNIKRAHFSALIERDIHEAVQNLVQPNK+FADAVDARQEIDLRIGASFTRFQTMLL
Subjt:  MDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTTANHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLL

Query:  KDAFNIDSVADDKNIVLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMCIQESTATVVNVRRQETLKY
        KDAFNIDSV DD+N+VLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNS DGISTFSWTRGNLFDYTCAVV YEMC++ESTATVVNVRRQETLKY
Subjt:  KDAFNIDSVADDKNIVLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMCIQESTATVVNVRRQETLKY

Query:  PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHGIVQEQQEHQMWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHP
        PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHGIVQEQQEHQ+WGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHP
Subjt:  PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHGIVQEQQEHQMWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHP

Query:  TKFSAGERGWSQDHHRLYELVVRHFLACVSQPA------VEHKHAHGLVEFAANEV-ARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGVTRPPP
        TKFSAGERGWSQDHHRLYELVVRHFLACVSQPA      VE   A  L   +   + ARNYLDVYRFESWGGSTIPTY SGQQFVPTTLTLDSGVTRPPP
Subjt:  TKFSAGERGWSQDHHRLYELVVRHFLACVSQPA------VEHKHAHGLVEFAANEV-ARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGVTRPPP

Query:  LLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYAMKDANTRFTPTN----LVMSLDFVHHYNLWKPHLRAIMEHEMKAVSEGTKRKDEVLATCLQQMKS
        LLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYA KDANTRFTPTN    LVM  D +  Y LWKPHLRA+MEHEMKAVSEG KRKDEVLATCLQQMKS
Subjt:  LLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYAMKDANTRFTPTN----LVMSLDFVHHYNLWKPHLRAIMEHEMKAVSEGTKRKDEVLATCLQQMKS

Query:  CFLDARVNKQKLLEAMEVFFERSNGTGGDENRAVGEVVQRCGLCQDSDMVLKRNRDGNYMVGCMAFPQCRNVVWLPGSIAEAAVTSDCCNSCTPGPVYLI
        CFLDAR NKQKL EAMEVFFERSNG+GGDEN AVGEVVQRC LCQDSDMVLKRNRDGNYMVGC+ FPQCRNVVWLPGSIAEAAVTS+ CNSCTPGPVYLI
Subjt:  CFLDARVNKQKLLEAMEVFFERSNGTGGDENRAVGEVVQRCGLCQDSDMVLKRNRDGNYMVGCMAFPQCRNVVWLPGSIAEAAVTSDCCNSCTPGPVYLI

Query:  QFKFRQLEIPPNYNANHLGCIGGCDDILRQLTEICGTGSRVSGMYLLCTRGRGTSSSSLQRDNTGQNVCIFCQQVGHSSNGCPSQVVGSRSARRRQSGDS
        QFKFRQLEIPPNYN NHLGCIGGCDDILRQLTEICGTGSR+S       RGRGTSSSS+QR NT Q+VC+FCQQ+ HSSN CPSQVVGSRSAR RQ+G+S
Subjt:  QFKFRQLEIPPNYNANHLGCIGGCDDILRQLTEICGTGSRVSGMYLLCTRGRGTSSSSLQRDNTGQNVCIFCQQVGHSSNGCPSQVVGSRSARRRQSGDS

Query:  SVSCSNCGTPCVLRTANTTNNRGRKFYKCQSQECNFFVWEDNVDNGNGGNSVPRSNIRSSGSAASNPNPGRNTGHGR----GRSRGQIAATFVSATGEPI
        S SCSNCGTPCVLRTANTTNNRGRKFYKCQSQECNFF WED+VD+ NGGNS  +SNIRSS SAASN NPGRNTG GR    G+ +GQIAATFVSATGEPI
Subjt:  SVSCSNCGTPCVLRTANTTNNRGRKFYKCQSQECNFFVWEDNVDNGNGGNSVPRSNIRSSGSAASNPNPGRNTGHGR----GRSRGQIAATFVSATGEPI

Query:  SDRRCFVCGDPSHFANVCPNRGA
        SDRRCFVCGDPSHFANVCPNRGA
Subjt:  SDRRCFVCGDPSHFANVCPNRGA

SwissProt top hits

e value

%identity

Alignment

C7J0A2 DNA topoisomerase 3-alpha

1.6e-306

63.58

Show/hide

Query:  DIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTTANHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLLK
        DIKRTLE+EAR+CQWLVLWLDCDREGENIA+EV+++C  AN  LNI RA FSALI+R+IHEAVQ+L +PNK FADAVDARQEIDLRIGASFTRFQTMLLK
Subjt:  DIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTTANHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLLK

Query:  DAFNIDSVADDKNIVLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMCIQESTATVVNVRRQETLKYP
        DAF +D   DD+NI+LSYGPCQFPTLGF+VER+WEIQ+HEPEEFWTINCSH SD+G ++F W RG+LFDY+ AVV YEMC++E  ATV NVR QE LKYP
Subjt:  DAFNIDSVADDKNIVLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMCIQESTATVVNVRRQETLKYP

Query:  PHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHGIVQEQQEHQMWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHPT
        P+PL+TIEL+KRASRYFRMSSEHTMKVAE+LYQAGFISYPRTETD FS  TDLH IV EQ  H  WG YAQRLLDP + LWRNPS GGHDDKAHPPIHPT
Subjt:  PHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHGIVQEQQEHQMWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHPT

Query:  KFSAGERGWSQDHHRLYELVVRHFLACVSQPAV------------EHKHAHGLVEFAANEVARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGVT
        KFSAGE  W+ +H +LYELVVRHFLAC SQPAV            E  +A G V      +A+NYLDVYRF+SWGG+ +PTY+ GQQFVPTTLTLDSG+T
Subjt:  KFSAGERGWSQDHHRLYELVVRHFLACVSQPAV------------EHKHAHGLVEFAANEVARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGVT

Query:  RPPPLLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYAMKDANTRFTPTN----LVMSLDFVHHYNLWKPHLRAIMEHEMKAVSEGTKRKDEVLATCLQ
        RPPPLL+EADLL CMDK GIGTDATMHDHIKKLLDR YA KDANTRF+PTN    LVM  D +  Y LWKP+LR++ME +MK+VS GTK K EVL  CLQ
Subjt:  RPPPLLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYAMKDANTRFTPTN----LVMSLDFVHHYNLWKPHLRAIMEHEMKAVSEGTKRKDEVLATCLQ

Query:  QMKSCFLDARVNKQKLLEAMEVFFERSNGTGGDENRAVGEVVQRCGLCQDSDMVLKRNRDGNYMVGCMAFPQCRNVVWLPGSIAEAAVTSDCCNSCTPGP
        QMK+CFLDAR NK KL +AM  FF RS+    +   ++ E V+ C  C +S+M LK+   G +MVGC  FPQCRNVVWLP S++ AAVT   C +C PGP
Subjt:  QMKSCFLDARVNKQKLLEAMEVFFERSNGTGGDENRAVGEVVQRCGLCQDSDMVLKRNRDGNYMVGCMAFPQCRNVVWLPGSIAEAAVTSDCCNSCTPGP

Query:  VYLIQFKFRQLEIPPNYNANHLGCIGGCDDILRQLTEICGTGSRVSGMYLLCTRGRGTSSSSLQRDNTGQNVCIFCQQVGHSSNGCPSQV--VGSRSARR
        VY IQFKFR+ +IPPN++ +HLGCIGGCDDIL++L E+   GS          R +  ++S +++ ++ Q++          +NG    V   G RS   
Subjt:  VYLIQFKFRQLEIPPNYNANHLGCIGGCDDILRQLTEICGTGSRVSGMYLLCTRGRGTSSSSLQRDNTGQNVCIFCQQVGHSSNGCPSQV--VGSRSARR

Query:  RQSGDSS--VSCSNCGTPCVLRTANTTNNRGRKFYKCQSQECNFFVWEDNVDN----GNGGNS-VPRSNIRSSGSAASNPNPGRNTGHG-RGRSRGQIAA
        + SG++S  V C++C  PCVLRTANT  NRGRKFYKCQ+  C FF WED+V+N    G GG     RS+ R S ++AS    G   G G RGR R     
Subjt:  RQSGDSS--VSCSNCGTPCVLRTANTTNNRGRKFYKCQSQECNFFVWEDNVDN----GNGGNS-VPRSNIRSSGSAASNPNPGRNTGHG-RGRSRGQIAA

Query:  TFVSATGEPISDRRCFVCGDPSHFANVCPNRG
         FV+ATGEP+    CF+CGDP+HFANVCPN G
Subjt:  TFVSATGEPISDRRCFVCGDPSHFANVCPNRG

O70157 DNA topoisomerase 3-alpha

5.4e-158

39.61

Show/hide

Query:  MDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTTANHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLL
        +DIK+TLE+E   CQ LV+W DCDREGENI FE++ VC     +L + RA FS +    +  A +NL +P++  +DAVD RQE+DLRIGA+FTRFQT+ L
Subjt:  MDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTTANHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLL

Query:  KDAFNIDSVADDKNIVLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMCIQESTATVVNVRRQETLKY
        +  F  + +A+    ++SYG CQFPTLGFVVER+  IQ+  PE F  I  +H+  DG   F+W R  LF++T  +V Y++C+++  ATVV VR +   K+
Subjt:  KDAFNIDSVADDKNIVLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMCIQESTATVVNVRRQETLKY

Query:  PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHGIVQEQQEHQMWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHP
         P  L+T+ELEK ASR  R++++ TM++AE LY  G+ISYPRTET+ F +  +L  +V++Q     WGA+AQ +L+ G      P  G   D+AHPPIHP
Subjt:  PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHGIVQEQQEHQMWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHP

Query:  TKFSAGERGWSQDHHRLYELVVRHFLACVSQP------------AVEHKHAHGLVEFAANEVARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGV
        TK+++G +G   D  RLYE +VRHFLAC SQ             A E   AHGL+      +ARNYLDVY ++ W    +P Y  G  F P+T+ +  G 
Subjt:  TKFSAGERGWSQDHHRLYELVVRHFLACVSQP------------AVEHKHAHGLVEFAANEVARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGV

Query:  TRPPPLLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYAMKDANTRFTPTNLVMSLDFVHH---YNLWKPHLRAIMEHEMKAVSEGTKRKDEVLATCLQ
        T PP LL+EADL++ M+K GIGTDAT  +HI+ +  R Y    ++ RF P +L M L   +    Y + KP LRA +E ++K + EG K K +VL   +Q
Subjt:  TRPPPLLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYAMKDANTRFTPTNLVMSLDFVHH---YNLWKPHLRAIMEHEMKAVSEGTKRKDEVLATCLQ

Query:  QMKSCFLDARVNKQKLLEAMEVFF-ERSNGTGGDE-NRAVGEVVQRCGLCQDSDMVLKRNRDGNYMVGCMAFPQCRNVVWLPGSIAEAAVTSDCCNSCTP
        + K  F++A    +KL EA+  +  ER+     +E   A+ E V++C  C + DMVLK  + G + + CM FP+CR+ VW P S+ EA+  +  C+ C P
Subjt:  QMKSCFLDARVNKQKLLEAMEVFF-ERSNGTGGDE-NRAVGEVVQRCGLCQDSDMVLKRNRDGNYMVGCMAFPQCRNVVWLPGSIAEAAVTSDCCNSCTP

Query:  GPVYLIQFKFRQLEIPPNYNANHLGCIGGCDDILRQLTEICGTGSRVSGMYLLCTRGRGTSSSSLQRDNTGQNVCIFCQQVGHSSNGCPSQVVGSRSARR
         PVY ++ KF++  +PP      +GCIGGCD+ L+   EI G     +        G   +S +L R ++ Q+      Q   + +  PS+ V       
Subjt:  GPVYLIQFKFRQLEIPPNYNANHLGCIGGCDDILRQLTEICGTGSRVSGMYLLCTRGRGTSSSSLQRDNTGQNVCIFCQQVGHSSNGCPSQVVGSRSARR

Query:  RQSGDSSVSCSNCGTPCVLRTANTTN-NRGRKFYKCQSQECNFFVWEDNVDNGNGG-----NSVPRSNIRSSGSAASNPNP----GRNTGHGRGRSRGQI
          +G+S+    NCG   VL T      N+GR FYKC + +CNFF+W D+  +  GG     +  P S++    S  S+ +     G ++  G     GQ 
Subjt:  RQSGDSSVSCSNCGTPCVLRTANTTN-NRGRKFYKCQSQECNFFVWEDNVDNGNGG-----NSVPRSNIRSSGSAASNPNP----GRNTGHGRGRSRGQI

Query:  AATFVSATGEPISDRRCFVCGDP
        A T       P   R+   C  P
Subjt:  AATFVSATGEPISDRRCFVCGDP

Q13472 DNA topoisomerase 3-alpha

1.8e-161

39.9

Show/hide

Query:  MDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTTANHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLL
        +DIK+TLE+E R+CQ LV+W DCDREGENI FE++ VC     +L + RA FS +    +  A +NL +P++  +DAVD RQE+DLRIGA+FTRFQT+ L
Subjt:  MDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTTANHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLL

Query:  KDAFNIDSVADDKNIVLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMCIQESTATVVNVRRQETLKY
        +  F  + +A+    ++SYG CQFPTLGFVVER+  IQ+  PE F  I  +H+  DGI  F+W R  LF++T  +V Y++C+++  ATVV VR +   K+
Subjt:  KDAFNIDSVADDKNIVLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMCIQESTATVVNVRRQETLKY

Query:  PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHGIVQEQQEHQMWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHP
         P  L+T+ELEK ASR  R++++ TM++AE LY  G+ISYPRTET+ F +  +L  +V++Q     WGA+AQ +L+ G      P  G   D+AHPPIHP
Subjt:  PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHGIVQEQQEHQMWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHP

Query:  TKFSAGERGWSQDHHRLYELVVRHFLACVSQP------------AVEHKHAHGLVEFAANEVARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGV
        TK++   +G   D  RLYE +VRHFLAC SQ             A E   AHGL+      +ARNYLDVY ++ W    +P Y  G  F P+T+ +  G 
Subjt:  TKFSAGERGWSQDHHRLYELVVRHFLACVSQP------------AVEHKHAHGLVEFAANEVARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGV

Query:  TRPPPLLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYAMKDANTRFTPTNLVMSLDFVHH---YNLWKPHLRAIMEHEMKAVSEGTKRKDEVLATCLQ
        T PP LL+EADL++ M+K GIGTDAT  +HI+ +  R Y     + RF P +L M L   +    Y + KP LRA +E ++K + +G K K  VL   +Q
Subjt:  TRPPPLLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYAMKDANTRFTPTNLVMSLDFVHH---YNLWKPHLRAIMEHEMKAVSEGTKRKDEVLATCLQ

Query:  QMKSCFLDARVNKQKLLEAMEVFFERSNGT----GGDENRAVGEVVQRCGLCQDSDMVLKRNRDGNYMVGCMAFPQCRNVVWLPGSIAEAAVTSDCCNSC
        + K  F++A    +KL EA+  +F   NGT      D   A+ E +++C  C + DMVLK  ++G + + CM FP+CR+ VWLP S+ EA+  S  C  C
Subjt:  QMKSCFLDARVNKQKLLEAMEVFFERSNGT----GGDENRAVGEVVQRCGLCQDSDMVLKRNRDGNYMVGCMAFPQCRNVVWLPGSIAEAAVTSDCCNSC

Query:  TPGPVYLIQFKFRQLEIPPNYNANHLGCIGGCDDILRQLTEICGTGSRVSGMYLLCTRGRGTSSSSLQRDNTGQNVCIFCQQVGHSSNGCPSQVVGSRSA
         P PVY ++ KF++  +PP      + CIGGCDD LR++ ++  +G            GR  ++ SL R +  Q+      Q   S     S+ +     
Subjt:  TPGPVYLIQFKFRQLEIPPNYNANHLGCIGGCDDILRQLTEICGTGSRVSGMYLLCTRGRGTSSSSLQRDNTGQNVCIFCQQVGHSSNGCPSQVVGSRSA

Query:  RRRQSGDSSVSCSNCGTPCVLRTANTTN-NRGRKFYKCQSQECNFFVWEDNVDNGNGGNSVPRSNIRSSGSAASNP-----------NPGRNTGHGRGRS
            +G+S+    NCG   VL T      NRGR+F+KC    CNFF+W D+ + G GG   P    R  G++   P           NPG  +G G    
Subjt:  RRRQSGDSSVSCSNCGTPCVLRTANTTN-NRGRKFYKCQSQECNFFVWEDNVDNGNGGNSVPRSNIRSSGSAASNP-----------NPGRNTGHGRGRS

Query:  RGQIAATFVSATGEPISDRRCFVCGDP
          Q + T       P   R+   C  P
Subjt:  RGQIAATFVSATGEPISDRRCFVCGDP

Q8T2T7 DNA topoisomerase 3

3.1e-121

41.13

Show/hide

Query:  IKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTTANHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLLKD
        +K+TLE+E ++   L+LWLDCDREGENIAFEV+EVC  A       RAHFSA+I R+I  A +NL +PN+  + AVD R EIDLRIGA+FTRFQT+ LK 
Subjt:  IKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTTANHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLLKD

Query:  AFNIDSVADDK---------NI------------VLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGIS------TFSWTRGNLFDYTCAV
         F I S +D++         NI            ++SYGPCQFPTLGFVVERY+ I + +PE+FW ++  H   D  S      TFSW R  LFDYT A 
Subjt:  AFNIDSVADDK---------NI------------VLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGIS------TFSWTRGNLFDYTCAV

Query:  VFYEMCIQESTATVVNVRRQETLKYPPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHGIVQEQQEHQMWGAYAQRLL
        + YE C+  + ATVV+V  +E+ +Y P PL TIEL+K AS+  R+SS  TM+ AE+LY  G ISYPRTETD F   TDL G++  Q  +  WGAYA RL+
Subjt:  VFYEMCIQESTATVVNVRRQETLKYPPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHGIVQEQQEHQMWGAYAQRLL

Query:  DPGSGLWRNPSGGGHDDKAHPPIHPTKFSAGERGWSQDHHRLYELVVRHFLACVSQPAVEHK-------HAHGLVEFAANEVARNYLDVYRFESWGGSTI
        +    ++  P  G ++D +HPPIHPT  + G  G   +  ++Y+ + R FLAC S+ +V                E     +   YL+VY F+      I
Subjt:  DPGSGLWRNPSGGGHDDKAHPPIHPTKFSAGERGWSQDHHRLYELVVRHFLACVSQPAVEHK-------HAHGLVEFAANEVARNYLDVYRFESWGGSTI

Query:  PTYVSGQQFVPTTLTLDSGVTRPPPLLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYAMKDANTRFTPTNLVMSLDFVHHYNLW-----KPHLRAIME
        PTY  G++F P  + L  G T  P  ++EA+LL+ MD   IGTDATM  HI+ + DRFY  K+ + +F P+NL +SL  V  Y L      KP+LRA +E
Subjt:  PTYVSGQQFVPTTLTLDSGVTRPPPLLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYAMKDANTRFTPTNLVMSLDFVHHYNLW-----KPHLRAIME

Query:  HEMKAVSEGTKRKDEVLATCLQQMKSCFLDARVNKQKLLEAMEVFFERSNGTGGDENRAVGEVVQRCGLCQDSDMVLKRNRDGNYMVGCMAFPQCRNVVW
         ++  +S G K K EVL + +++ K  +  A  N      +   ++E ++  GG E R +     RCG C +  M  K +++       +  PQC +   
Subjt:  HEMKAVSEGTKRKDEVLATCLQQMKSCFLDARVNKQKLLEAMEVFFERSNGTGGDENRAVGEVVQRCGLCQDSDMVLKRNRDGNYMVGCMAFPQCRNVVW

Query:  LP--GSIAEAAVTSDCCNSC
        LP  G I++   +     +C
Subjt:  LP--GSIAEAAVTSDCCNSC

Q9LVP1 DNA topoisomerase 3-alpha

0.0e+00

66.59

Show/hide

Query:  DIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTTANHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLLK
        DIK+TLE+EAR+  WLVLWLDCDREGENIAFEVV+VC    H+L I+RAHFSALI+RDIHEAVQNL  PN+ FA+AVDARQEIDLRIGASFTRFQTMLL+
Subjt:  DIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTTANHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLLK

Query:  DAFNIDSVADDKNIVLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMCIQESTATVVNV-RRQETLKY
        D F IDS  ++++ V+SYGPCQFPTLGF+VERYWEIQ+HEPEEFWTINCSH S++G++TF+W RG+LFDY  AV+ YEMC++E TATV+NV   +E  KY
Subjt:  DAFNIDSVADDKNIVLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMCIQESTATVVNV-RRQETLKY

Query:  PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHGIVQEQQEHQMWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHP
        PP+PLNTIELEKRASRYFR+SSEHTMKVAE+LYQAGFISYPRTETD FS RTDL  +V+EQ  H  WG+YAQRLL+P  GLWRNP+ GGHDDKAHPPIHP
Subjt:  PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHGIVQEQQEHQMWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHP

Query:  TKFSAGERGWSQDHHRLYELVVRHFLACVSQPAVEHKHAHGLVE-------FAANE---VARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGVTR
        TKFS+GE  WS+DH  +YELVVRH+LACVSQPAV    A   VE       F+A+    +A+NYL+VYRFESWGGS IP Y  GQQF+PTTLTLD+ VTR
Subjt:  TKFSAGERGWSQDHHRLYELVVRHFLACVSQPAVEHKHAHGLVE-------FAANE---VARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGVTR

Query:  PPPLLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYAMKDANTRFTPTN----LVMSLDFVHHYNLWKPHLRAIMEHEMKAVSEGTKRKDEVLATCLQQ
        PPPLL EADLLSCMDK GIGTDATMHDHIKKLLDR YA KDANTRF+PTN    LVM  D +  Y LWKP+LRA+MEH+M  VS G K K EVL TCLQQ
Subjt:  PPPLLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYAMKDANTRFTPTN----LVMSLDFVHHYNLWKPHLRAIMEHEMKAVSEGTKRKDEVLATCLQQ

Query:  MKSCFLDARVNKQKLLEAMEVFFERSNGTGGDENRAVGEVVQRCGLCQDSDMVLKRNRDGNYMVGCMAFPQCRNVVWLPGSIAEAAVTSDCCNSCTPGPV
        MK+CFLDARV K KLLEAM +FFERSN T   E++  GEVV+RC LC +SDM L++NRDGN+MVGCM +PQCRN VWLPG   EA+VT++ C SC PGPV
Subjt:  MKSCFLDARVNKQKLLEAMEVFFERSNGTGGDENRAVGEVVQRCGLCQDSDMVLKRNRDGNYMVGCMAFPQCRNVVWLPGSIAEAAVTSDCCNSCTPGPV

Query:  YLIQFKFRQLEIPPNYNANHLGCIGGCDDILRQLTEICGTGSRVSGMYLLCTRGRGTS-SSSLQRDNTGQ-NVCIFCQQVGHSSNGCPSQVVGSRSAR--
        Y I FKFRQ+ IPP ++ NHLGC+GGCDDIL+QL +ICGTGSR         R  GT+ S+++Q  NT Q NVCI CQQ GH+S  CPS+V  SR++R  
Subjt:  YLIQFKFRQLEIPPNYNANHLGCIGGCDDILRQLTEICGTGSRVSGMYLLCTRGRGTS-SSSLQRDNTGQ-NVCIFCQQVGHSSNGCPSQVVGSRSAR--

Query:  --RRQSGDSSVSCSNCGTPCVLRTANTTNNRGRKFYKCQSQECNFFVWEDNVDNGNGGNSVPRSNIRSSGSAASNPNPGRNTGHGRGRSRG---QIAATF
            ++ +S+VSC+ CG+ CVLRTANT  NRGR+F+ C +Q C+FF WED+++N + GN+   SN   SG   S    GR  G   G+S G       +F
Subjt:  --RRQSGDSSVSCSNCGTPCVLRTANTTNNRGRKFYKCQSQECNFFVWEDNVDNGNGGNSVPRSNIRSSGSAASNPNPGRNTGHGRGRSRG---QIAATF

Query:  VSATGEPISDRRCFVCGDPSHFANVCPNR
        VSATGEP+S  RCF CGDPSHFAN CPNR
Subjt:  VSATGEPISDRRCFVCGDPSHFANVCPNR

Arabidopsis top hits

e value

%identity

Alignment

AT2G32000.1 DNA topoisomerase, type IA, core

1.5e-81

34.97

Show/hide

Query:  IKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVC--TTANHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLL
        I R L  EAR C ++VLWLDCDREGENI FEV+E       +    + RA FS++ E+DI +A+ NLV+PN+  A AVDARQEIDL++G +F+RFQT   
Subjt:  IKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVC--TTANHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLL

Query:  KDAF-NIDSVADDKNIVLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMCIQESTATVVNVRRQETLK
        +  + N+D        V+SYGPCQ PTLGF V+RY  I + +PE+FW +      D       W R  LFD   A VF ++ ++  TA V++V  ++ +K
Subjt:  KDAF-NIDSVADDKNIVLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMCIQESTATVVNVRRQETLK

Query:  YPPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHGIVQEQQEHQMWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIH
          P  LNT+ L K AS       +  M +AE LY  GFISYPRTE+  +    D    ++ Q  + +WG Y QRLL  G  + ++    G D   HPPI 
Subjt:  YPPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHGIVQEQQEHQMWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIH

Query:  PTKFSAGERGWSQDHHRLYELVVRHFLACVSQPAVEHKHAHGLVEFA----------ANEVARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGVT
        P + +A E     D  RLY+ V +HFL  VS      K+    VE +               + +  +  + +     +P+++ G++     + L  G T
Subjt:  PTKFSAGERGWSQDHHRLYELVVRHFLACVSQPAVEHKHAHGLVEFA----------ANEVARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGVT

Query:  RPPPLLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYAMKDANTRFTPTNLVMSLDFVHHY-----NLWKPHLRAIMEHEMKAVSEGTKRKDEVLATCL
         PP  L+E++L+S M+K GIGTDA++  HI  + +R Y    +  +  PT L ++L  +  Y     +L  P +R+ +E ++  V++G      V+   +
Subjt:  RPPPLLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYAMKDANTRFTPTNLVMSLDFVHHY-----NLWKPHLRAIMEHEMKAVSEGTKRKDEVLATCL

Query:  QQMKSCFLDARVNKQKLLEAMEVFFERSNGTGGDENRAVGEVVQRCGLC
        QQ +  F        + +E M+  FE       D  RA    + +CG C
Subjt:  QQMKSCFLDARVNKQKLLEAMEVFFERSNGTGGDENRAVGEVVQRCGLC

AT2G32000.2 DNA topoisomerase, type IA, core

1.5e-81

34.97

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Query:  IKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVC--TTANHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLL
        I R L  EAR C ++VLWLDCDREGENI FEV+E       +    + RA FS++ E+DI +A+ NLV+PN+  A AVDARQEIDL++G +F+RFQT   
Subjt:  IKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVC--TTANHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLL

Query:  KDAF-NIDSVADDKNIVLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMCIQESTATVVNVRRQETLK
        +  + N+D        V+SYGPCQ PTLGF V+RY  I + +PE+FW +      D       W R  LFD   A VF ++ ++  TA V++V  ++ +K
Subjt:  KDAF-NIDSVADDKNIVLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMCIQESTATVVNVRRQETLK

Query:  YPPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHGIVQEQQEHQMWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIH
          P  LNT+ L K AS       +  M +AE LY  GFISYPRTE+  +    D    ++ Q  + +WG Y QRLL  G  + ++    G D   HPPI 
Subjt:  YPPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHGIVQEQQEHQMWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIH

Query:  PTKFSAGERGWSQDHHRLYELVVRHFLACVSQPAVEHKHAHGLVEFA----------ANEVARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGVT
        P + +A E     D  RLY+ V +HFL  VS      K+    VE +               + +  +  + +     +P+++ G++     + L  G T
Subjt:  PTKFSAGERGWSQDHHRLYELVVRHFLACVSQPAVEHKHAHGLVEFA----------ANEVARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGVT

Query:  RPPPLLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYAMKDANTRFTPTNLVMSLDFVHHY-----NLWKPHLRAIMEHEMKAVSEGTKRKDEVLATCL
         PP  L+E++L+S M+K GIGTDA++  HI  + +R Y    +  +  PT L ++L  +  Y     +L  P +R+ +E ++  V++G      V+   +
Subjt:  RPPPLLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYAMKDANTRFTPTNLVMSLDFVHHY-----NLWKPHLRAIMEHEMKAVSEGTKRKDEVLATCL

Query:  QQMKSCFLDARVNKQKLLEAMEVFFERSNGTGGDENRAVGEVVQRCGLC
        QQ +  F        + +E M+  FE       D  RA    + +CG C
Subjt:  QQMKSCFLDARVNKQKLLEAMEVFFERSNGTGGDENRAVGEVVQRCGLC

AT4G31210.1 DNA topoisomerase, type IA, core

2.3e-18

22.46

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Query:  LVLWLDCDREGENIAFEVVEVCT---TANHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLLKDAFNIDSVADDK
        L+L  D DREGE IA+ ++E+       +  + + R  F  + E  I  A+Q+  + +     A  AR+ +D  IG              FNI  +   K
Subjt:  LVLWLDCDREGENIAFEVVEVCT---TANHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLLKDAFNIDSVADDK

Query:  -NIVLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFSWTRGNL---------FDYTCAVVFYEMCIQESTATVVNVRRQETLKYPPH
             S G  Q   L  V +R  EI   +P+E+WT+       D  +TFS    +L                   E  I+     V   +   T K PP 
Subjt:  -NIVLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFSWTRGNL---------FDYTCAVVFYEMCIQESTATVVNVRRQETLKYPPH

Query:  PLNTIELEKRASRYFRMSSEHTMKVAEDLYQ---------AGFISYPRTETDCFSQRT--DLHGIVQEQQEHQMWGAYAQRLLDPGSGLWRNPSGGGHDD
        P  T  L++ A+     S+ HTMK+A+ LY+         AG I+Y RT+    +     D+  +V E+          ++                +  
Subjt:  PLNTIELEKRASRYFRMSSEHTMKVAEDLYQ---------AGFISYPRTETDCFSQRT--DLHGIVQEQQEHQMWGAYAQRLLDPGSGLWRNPSGGGHDD

Query:  KAHPPIHPTKF----SAGERGWSQDHHRLYELVVRHFLACVSQPA---------------VEHKHAHGLVEF----------AANEVARNYLDVYRFESW
        +AH  I PT      S        D  +LY L+    +AC  +PA               +  + +   VEF           A  +  N  D       
Subjt:  KAHPPIHPTKF----SAGERGWSQDHHRLYELVVRHFLACVSQPA---------------VEHKHAHGLVEF----------AANEVARNYLDVYRFESW

Query:  GGSTIPTYVSGQQFVPTTLTLDSGVTRPPPLLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYAMKDANTRFTPTNLVMSLDFVHHY--NLWKPHLRAI
           T+ +   G       + L    T+ PP  SE  L+  +++ GIG  +T     + L  R Y        +      M   F+ HY   +      A 
Subjt:  GGSTIPTYVSGQQFVPTTLTLDSGVTRPPPLLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYAMKDANTRFTPTNLVMSLDFVHHY--NLWKPHLRAI

Query:  MEHEMKAVSEGTKRKDEVLATCLQQMKS-CFLDARVNKQKLLEAMEVFFERSNGTGGDENRAVGEVVQR-CGLCQDSDMVLKRNRDG-NYMVGCMAFPQC
        ME E+  VS G      +L     +  + C     V + ++ + +E  +E       D   ++     R C  C +  +  K ++ G  Y +GC   P C
Subjt:  MEHEMKAVSEGTKRKDEVLATCLQQMKS-CFLDARVNKQKLLEAMEVFFERSNGTGGDENRAVGEVVQR-CGLCQDSDMVLKRNRDG-NYMVGCMAFPQC

Query:  R
        +
Subjt:  R

AT5G13920.1 GRF zinc finger / Zinc knuckle protein

4.5e-06

38.16

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Query:  CIFCQQVGHSSNGCPSQVVGSRSARRRQSGDSSVSCSNCGTPCVLRTANTTNNRGRKFYKC-QSQECNFFVWEDNV
        C  C+Q GH  N CP +               ++ C   G  C ++ ANT  N GRKFYKC  +Q C FF W D V
Subjt:  CIFCQQVGHSSNGCPSQVVGSRSARRRQSGDSSVSCSNCGTPCVLRTANTTNNRGRKFYKC-QSQECNFFVWEDNV

AT5G63920.1 topoisomerase 3alpha

0.0e+00

66.59

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Query:  DIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTTANHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLLK
        DIK+TLE+EAR+  WLVLWLDCDREGENIAFEVV+VC    H+L I+RAHFSALI+RDIHEAVQNL  PN+ FA+AVDARQEIDLRIGASFTRFQTMLL+
Subjt:  DIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTTANHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLLK

Query:  DAFNIDSVADDKNIVLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMCIQESTATVVNV-RRQETLKY
        D F IDS  ++++ V+SYGPCQFPTLGF+VERYWEIQ+HEPEEFWTINCSH S++G++TF+W RG+LFDY  AV+ YEMC++E TATV+NV   +E  KY
Subjt:  DAFNIDSVADDKNIVLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMCIQESTATVVNV-RRQETLKY

Query:  PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHGIVQEQQEHQMWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHP
        PP+PLNTIELEKRASRYFR+SSEHTMKVAE+LYQAGFISYPRTETD FS RTDL  +V+EQ  H  WG+YAQRLL+P  GLWRNP+ GGHDDKAHPPIHP
Subjt:  PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHGIVQEQQEHQMWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHP

Query:  TKFSAGERGWSQDHHRLYELVVRHFLACVSQPAVEHKHAHGLVE-------FAANE---VARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGVTR
        TKFS+GE  WS+DH  +YELVVRH+LACVSQPAV    A   VE       F+A+    +A+NYL+VYRFESWGGS IP Y  GQQF+PTTLTLD+ VTR
Subjt:  TKFSAGERGWSQDHHRLYELVVRHFLACVSQPAVEHKHAHGLVE-------FAANE---VARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGVTR

Query:  PPPLLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYAMKDANTRFTPTN----LVMSLDFVHHYNLWKPHLRAIMEHEMKAVSEGTKRKDEVLATCLQQ
        PPPLL EADLLSCMDK GIGTDATMHDHIKKLLDR YA KDANTRF+PTN    LVM  D +  Y LWKP+LRA+MEH+M  VS G K K EVL TCLQQ
Subjt:  PPPLLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYAMKDANTRFTPTN----LVMSLDFVHHYNLWKPHLRAIMEHEMKAVSEGTKRKDEVLATCLQQ

Query:  MKSCFLDARVNKQKLLEAMEVFFERSNGTGGDENRAVGEVVQRCGLCQDSDMVLKRNRDGNYMVGCMAFPQCRNVVWLPGSIAEAAVTSDCCNSCTPGPV
        MK+CFLDARV K KLLEAM +FFERSN T   E++  GEVV+RC LC +SDM L++NRDGN+MVGCM +PQCRN VWLPG   EA+VT++ C SC PGPV
Subjt:  MKSCFLDARVNKQKLLEAMEVFFERSNGTGGDENRAVGEVVQRCGLCQDSDMVLKRNRDGNYMVGCMAFPQCRNVVWLPGSIAEAAVTSDCCNSCTPGPV

Query:  YLIQFKFRQLEIPPNYNANHLGCIGGCDDILRQLTEICGTGSRVSGMYLLCTRGRGTS-SSSLQRDNTGQ-NVCIFCQQVGHSSNGCPSQVVGSRSAR--
        Y I FKFRQ+ IPP ++ NHLGC+GGCDDIL+QL +ICGTGSR         R  GT+ S+++Q  NT Q NVCI CQQ GH+S  CPS+V  SR++R  
Subjt:  YLIQFKFRQLEIPPNYNANHLGCIGGCDDILRQLTEICGTGSRVSGMYLLCTRGRGTS-SSSLQRDNTGQ-NVCIFCQQVGHSSNGCPSQVVGSRSAR--

Query:  --RRQSGDSSVSCSNCGTPCVLRTANTTNNRGRKFYKCQSQECNFFVWEDNVDNGNGGNSVPRSNIRSSGSAASNPNPGRNTGHGRGRSRG---QIAATF
            ++ +S+VSC+ CG+ CVLRTANT  NRGR+F+ C +Q C+FF WED+++N + GN+   SN   SG   S    GR  G   G+S G       +F
Subjt:  --RRQSGDSSVSCSNCGTPCVLRTANTTNNRGRKFYKCQSQECNFFVWEDNVDNGNGGNSVPRSNIRSSGSAASNPNPGRNTGHGRGRSRG---QIAATF

Query:  VSATGEPISDRRCFVCGDPSHFANVCPNR
        VSATGEP+S  RCF CGDPSHFAN CPNR
Subjt:  VSATGEPISDRRCFVCGDPSHFANVCPNR

Sequences

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CDS sequence

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ATGGATATAAAGAGGACTTTGGAACAAGAAGCTAGAAGGTGCCAATGGCTCGTCCTTTGGCTTGATTGTGATAGAGAAGGAGAGAATATTGCATTTGAAGTGGTGGAAGT
TTGCACAACAGCGAATCACCATCTTAACATTAAGAGAGCTCACTTCTCTGCTTTGATCGAAAGGGATATTCACGAAGCTGTGCAAAATCTTGTCCAACCGAATAAATGGT
TTGCTGATGCAGTTGATGCTAGACAAGAAATCGATCTAAGAATTGGAGCTTCTTTCACTAGGTTCCAAACTATGCTGTTGAAAGATGCATTTAATATTGATTCTGTCGCA
GATGACAAAAATATTGTGTTGAGTTATGGGCCATGTCAGTTTCCTACTCTTGGCTTTGTTGTTGAGCGGTACTGGGAGATTCAATCCCATGAGCCAGAAGAATTTTGGAC
GATCAACTGTTCACACAATTCTGATGATGGGATTTCTACATTTAGTTGGACAAGAGGGAATCTATTTGATTATACTTGTGCTGTTGTATTCTATGAAATGTGCATACAAG
AATCCACTGCTACGGTTGTAAATGTTAGACGACAAGAGACGTTAAAGTACCCTCCTCATCCATTGAATACAATTGAGCTTGAAAAACGAGCTTCACGATACTTCCGAATG
AGTTCTGAACACACCATGAAGGTGGCCGAAGATCTATACCAAGCAGGTTTCATTAGTTATCCTCGTACAGAGACTGATTGCTTTTCTCAAAGGACCGATCTTCATGGCAT
TGTGCAAGAACAACAAGAACACCAGATGTGGGGAGCGTATGCACAAAGGTTGTTGGATCCTGGATCAGGGCTGTGGAGGAATCCTAGTGGTGGTGGGCATGATGACAAAG
CCCATCCACCTATTCACCCAACAAAGTTCTCAGCTGGGGAACGCGGATGGAGCCAAGATCACCATAGATTATATGAGCTAGTCGTTCGCCATTTCCTTGCATGTGTGTCA
CAGCCAGCTGTAGAACATAAGCATGCTCATGGGTTGGTGGAATTTGCTGCTAATGAAGTGGCAAGAAATTACCTGGATGTTTACCGCTTTGAATCATGGGGAGGTTCAAC
TATTCCAACATACGTTTCCGGGCAACAGTTTGTTCCAACAACATTAACTCTTGATTCGGGAGTCACGAGACCACCTCCCCTTCTGAGTGAAGCTGATTTGCTTTCTTGTA
TGGATAAGGAGGGAATTGGTACAGATGCAACAATGCATGACCACATCAAGAAGCTGTTGGATAGATTTTATGCAATGAAGGATGCAAACACTCGGTTCACACCAACTAAC
CTTGTAATGAGCTTGGATTTTGTCCATCATTATAACCTGTGGAAACCACACCTTAGAGCAATTATGGAGCATGAGATGAAAGCAGTTAGTGAGGGCACTAAGAGAAAAGA
TGAAGTGTTGGCTACATGCTTGCAGCAGATGAAATCTTGCTTCTTAGATGCAAGGGTCAATAAGCAAAAACTTCTTGAAGCTATGGAGGTTTTCTTTGAGAGATCTAATG
GTACTGGCGGGGATGAAAATCGTGCAGTTGGAGAAGTTGTTCAGCGGTGTGGATTGTGTCAGGACTCAGATATGGTGCTTAAAAGAAACAGGGATGGAAATTACATGGTT
GGATGCATGGCCTTTCCCCAGTGTAGAAATGTTGTCTGGCTCCCAGGATCCATTGCAGAAGCTGCAGTAACCTCTGATTGTTGCAATTCATGCACTCCAGGTCCTGTTTA
CTTGATCCAATTTAAGTTTCGCCAGCTGGAAATACCACCAAACTACAATGCTAACCACTTGGGTTGTATCGGTGGTTGTGATGATATTCTTAGGCAACTGACTGAAATCT
GTGGTACTGGATCCCGCGTATCAGGCATGTACCTTTTGTGCACTAGAGGTCGAGGGACTTCATCATCCAGTCTGCAGCGGGATAACACCGGGCAAAATGTATGCATTTTC
TGCCAACAAGTAGGGCATTCCTCAAATGGTTGCCCTTCCCAGGTTGTTGGTTCCAGAAGTGCTCGTCGTCGGCAAAGTGGAGACTCTTCAGTTTCATGTAGTAACTGTGG
CACACCATGCGTCTTACGGACTGCTAATACTACCAATAATAGGGGAAGAAAGTTCTACAAATGTCAATCTCAGGAGTGCAATTTCTTCGTATGGGAAGACAACGTAGACA
ATGGCAATGGAGGAAATAGTGTTCCACGATCAAACATCAGGAGCTCAGGCTCTGCAGCATCTAATCCTAACCCTGGTCGAAACACTGGACATGGTCGTGGTCGCAGTCGG
GGTCAGATTGCAGCGACATTTGTATCAGCAACTGGTGAGCCAATATCTGATAGAAGATGTTTTGTTTGTGGTGATCCGTCACACTTCGCAAATGTTTGCCCTAACCGTGG
TGCTTGA

mRNA sequence

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Protein sequence

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MDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTTANHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLLKDAFNIDSVA
DDKNIVLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMCIQESTATVVNVRRQETLKYPPHPLNTIELEKRASRYFRM
SSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHGIVQEQQEHQMWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHPTKFSAGERGWSQDHHRLYELVVRHFLACVS
QPAVEHKHAHGLVEFAANEVARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGVTRPPPLLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYAMKDANTRFTPTN
LVMSLDFVHHYNLWKPHLRAIMEHEMKAVSEGTKRKDEVLATCLQQMKSCFLDARVNKQKLLEAMEVFFERSNGTGGDENRAVGEVVQRCGLCQDSDMVLKRNRDGNYMV
GCMAFPQCRNVVWLPGSIAEAAVTSDCCNSCTPGPVYLIQFKFRQLEIPPNYNANHLGCIGGCDDILRQLTEICGTGSRVSGMYLLCTRGRGTSSSSLQRDNTGQNVCIF
CQQVGHSSNGCPSQVVGSRSARRRQSGDSSVSCSNCGTPCVLRTANTTNNRGRKFYKCQSQECNFFVWEDNVDNGNGGNSVPRSNIRSSGSAASNPNPGRNTGHGRGRSR
GQIAATFVSATGEPISDRRCFVCGDPSHFANVCPNRGA

HG10019911 (gene) of Bottle gourd (Hangzhou Gourd) v1 genome