CuGenDBv2

Gene ID	HG10019912
Organism	Lagenaria siceraria cv. Hangzhou Gourd (Bottle gourd (Hangzhou Gourd) v1)
Description	DNA topoisomerase
Genome location	Chr04:26840691..26841443
RNA-Seq Expression	HG10019912
Synteny	HG10019912
Gene Ontology terms	GO:0006265 - DNA topological change (biological process) GO:0005634 - nucleus (cellular component) GO:0005694 - chromosome (cellular component) GO:0003677 - DNA binding (molecular function) GO:0003917 - DNA topoisomerase type I activity (molecular function) GO:0008270 - zinc ion binding (molecular function)
InterPro domains	IPR000380 - DNA topoisomerase, type IA IPR023405 - DNA topoisomerase, type IA, core domain

Homology

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GenBank top hits

e value

%identity

Alignment

XP_022154286.1 DNA topoisomerase 3-alpha [Momordica charantia]

1.5e-45

92.86

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Query:  MSSGRPITVLNVAEKPSVAKSVATILSRNQGLRVREGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELDFEERYRKWHSCDPVQLFHAPIRKFVPE
        MS GRPITVLNVAEKPSVAK+VATILSRNQGLRVR+GRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMEL+FEERYRKWHSCDP  LFHAP+RKFVPE
Subjt:  MSSGRPITVLNVAEKPSVAKSVATILSRNQGLRVREGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELDFEERYRKWHSCDPVQLFHAPIRKFVPE

XP_022934066.1 DNA topoisomerase 3-alpha isoform X1 [Cucurbita moschata]

4.4e-45

92.86

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Query:  MSSGRPITVLNVAEKPSVAKSVATILSRNQGLRVREGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELDFEERYRKWHSCDPVQLFHAPIRKFVPE
        M+ GRPITVLNVAEKPSVAKSVATILSRNQGLRVREGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMEL+FEERYRKWHSCDPV+LF+AP+RK VPE
Subjt:  MSSGRPITVLNVAEKPSVAKSVATILSRNQGLRVREGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELDFEERYRKWHSCDPVQLFHAPIRKFVPE

XP_022934067.1 DNA topoisomerase 3-alpha isoform X2 [Cucurbita moschata]

4.4e-45

92.86

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Query:  MSSGRPITVLNVAEKPSVAKSVATILSRNQGLRVREGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELDFEERYRKWHSCDPVQLFHAPIRKFVPE
        M+ GRPITVLNVAEKPSVAKSVATILSRNQGLRVREGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMEL+FEERYRKWHSCDPV+LF+AP+RK VPE
Subjt:  MSSGRPITVLNVAEKPSVAKSVATILSRNQGLRVREGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELDFEERYRKWHSCDPVQLFHAPIRKFVPE

XP_038904101.1 DNA topoisomerase 3-alpha isoform X1 [Benincasa hispida]

6.9e-46

93.88

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Query:  MSSGRPITVLNVAEKPSVAKSVATILSRNQGLRVREGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELDFEERYRKWHSCDPVQLFHAPIRKFVPE
        MS GRPITVLNVAEKPSVAKSVATILSRNQGLRVR+GRSRYNKIFEFNYAIRGQSCNM+VTSVTGHLMEL+FEERYRKWHSCDPVQLFHAP+RK VPE
Subjt:  MSSGRPITVLNVAEKPSVAKSVATILSRNQGLRVREGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELDFEERYRKWHSCDPVQLFHAPIRKFVPE

XP_038904102.1 DNA topoisomerase 3-alpha isoform X2 [Benincasa hispida]

6.9e-46

93.88

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Query:  MSSGRPITVLNVAEKPSVAKSVATILSRNQGLRVREGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELDFEERYRKWHSCDPVQLFHAPIRKFVPE
        MS GRPITVLNVAEKPSVAKSVATILSRNQGLRVR+GRSRYNKIFEFNYAIRGQSCNM+VTSVTGHLMEL+FEERYRKWHSCDPVQLFHAP+RK VPE
Subjt:  MSSGRPITVLNVAEKPSVAKSVATILSRNQGLRVREGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELDFEERYRKWHSCDPVQLFHAPIRKFVPE

TrEMBL top hits

e value

%identity

Alignment

A0A6J1DNA0 DNA topoisomerase

7.4e-46

92.86

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Query:  MSSGRPITVLNVAEKPSVAKSVATILSRNQGLRVREGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELDFEERYRKWHSCDPVQLFHAPIRKFVPE
        MS GRPITVLNVAEKPSVAK+VATILSRNQGLRVR+GRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMEL+FEERYRKWHSCDP  LFHAP+RKFVPE
Subjt:  MSSGRPITVLNVAEKPSVAKSVATILSRNQGLRVREGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELDFEERYRKWHSCDPVQLFHAPIRKFVPE

A0A6J1F0T9 DNA topoisomerase

2.2e-45

92.86

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Query:  MSSGRPITVLNVAEKPSVAKSVATILSRNQGLRVREGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELDFEERYRKWHSCDPVQLFHAPIRKFVPE
        M+ GRPITVLNVAEKPSVAKSVATILSRNQGLRVREGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMEL+FEERYRKWHSCDPV+LF+AP+RK VPE
Subjt:  MSSGRPITVLNVAEKPSVAKSVATILSRNQGLRVREGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELDFEERYRKWHSCDPVQLFHAPIRKFVPE

A0A6J1F1M3 DNA topoisomerase

2.2e-45

92.86

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Query:  MSSGRPITVLNVAEKPSVAKSVATILSRNQGLRVREGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELDFEERYRKWHSCDPVQLFHAPIRKFVPE
        M+ GRPITVLNVAEKPSVAKSVATILSRNQGLRVREGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMEL+FEERYRKWHSCDPV+LF+AP+RK VPE
Subjt:  MSSGRPITVLNVAEKPSVAKSVATILSRNQGLRVREGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELDFEERYRKWHSCDPVQLFHAPIRKFVPE

A0A6J1IXM8 DNA topoisomerase

2.2e-45

92.86

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Query:  MSSGRPITVLNVAEKPSVAKSVATILSRNQGLRVREGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELDFEERYRKWHSCDPVQLFHAPIRKFVPE
        M+ GRPITVLNVAEKPSVAKSVATILSRNQGLRVREGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMEL+FEERYRKWHSCDPV+LF+AP+RK VPE
Subjt:  MSSGRPITVLNVAEKPSVAKSVATILSRNQGLRVREGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELDFEERYRKWHSCDPVQLFHAPIRKFVPE

A0A6J1J603 DNA topoisomerase

2.2e-45

92.86

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Query:  MSSGRPITVLNVAEKPSVAKSVATILSRNQGLRVREGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELDFEERYRKWHSCDPVQLFHAPIRKFVPE
        M+ GRPITVLNVAEKPSVAKSVATILSRNQGLRVREGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMEL+FEERYRKWHSCDPV+LF+AP+RK VPE
Subjt:  MSSGRPITVLNVAEKPSVAKSVATILSRNQGLRVREGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELDFEERYRKWHSCDPVQLFHAPIRKFVPE

SwissProt top hits

e value

%identity

Alignment

C7J0A2 DNA topoisomerase 3-alpha

7.4e-35

71.88

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Query:  GRPITVLNVAEKPSVAKSVATILSR-NQGLRVREGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELDFEERYRKWHSCDPVQLFHAPIRKFVPE
        G  I VLNVAEKPSVAKSVA ILSR + G+R REGRSRYN++FEF+Y+I G++C+MLVTSVTGHLMEL+F++R+R+WHSCDP  LFHAP+RK VP+
Subjt:  GRPITVLNVAEKPSVAKSVATILSR-NQGLRVREGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELDFEERYRKWHSCDPVQLFHAPIRKFVPE

O70157 DNA topoisomerase 3-alpha

1.5e-19

51.11

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Query:  VLNVAEKPSVAKSVATILSRNQGLRVREGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELDFEERYRKWHSCDPVQLFHAPIRKFVPE
        VL VAEK   AK +A +LS N  +R +EG S++NKI+EF+Y + GQ+  M++TSV+GHL+  DF+ ++RKW SC+P+ LF A I K+ PE
Subjt:  VLNVAEKPSVAKSVATILSRNQGLRVREGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELDFEERYRKWHSCDPVQLFHAPIRKFVPE

Q13472 DNA topoisomerase 3-alpha

8.8e-20

52.22

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Query:  VLNVAEKPSVAKSVATILSRNQGLRVREGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELDFEERYRKWHSCDPVQLFHAPIRKFVPE
        VL VAEK   AK +A +LS N  +R REG S++NKI+EF+Y + GQ+  M++TSV+GHL+  DF+ ++RKW SC+P+ LF A I K+ PE
Subjt:  VLNVAEKPSVAKSVATILSRNQGLRVREGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELDFEERYRKWHSCDPVQLFHAPIRKFVPE

Q8T2T7 DNA topoisomerase 3

6.5e-23

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Query:  VLNVAEKPSVAKSVATILSRNQGLRVREGRSRYNKIFEFNYAIRG-QSCNMLVTSVTGHLMELDFEERYRKWHSCDPVQLFHAPIRKFVP
        +LNVAEKPS AK +A ILS N+   VREG S+YNK+++F Y I     C M  TSVTGHLME+D  E+++ W SCDP+QLF APIRK VP
Subjt:  VLNVAEKPSVAKSVATILSRNQGLRVREGRSRYNKIFEFNYAIRG-QSCNMLVTSVTGHLMELDFEERYRKWHSCDPVQLFHAPIRKFVP

Q9LVP1 DNA topoisomerase 3-alpha

1.3e-34

74.74

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Query:  GRPITVLNVAEKPSVAKSVATILSRNQGLRVREGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELDFEERYRKWHSCDPVQLFHAPIRKFVPE
        G P+TVLNVAEKPSVAKSVA ILSR    R REGRSRYNKIFEF+YAI GQ C ML+TSV GHLMEL+F +RYRKWHSCDP  L+ AP+ K VPE
Subjt:  GRPITVLNVAEKPSVAKSVATILSRNQGLRVREGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELDFEERYRKWHSCDPVQLFHAPIRKFVPE

Arabidopsis top hits

e value

%identity

Alignment

AT2G32000.1 DNA topoisomerase, type IA, core

2.1e-13

44.32

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Query:  ITVLNVAEKPSVAKSVATILSRNQGLRVREGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELDFEERYRKWHSCDPVQLFHAPIRK
        + VL VAEKPS+A S+A++LS  Q +  R G +   ++ EF+   RG   +  VTSV GH+  +DF E+Y+ W + DP  LF API K
Subjt:  ITVLNVAEKPSVAKSVATILSRNQGLRVREGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELDFEERYRKWHSCDPVQLFHAPIRK

AT5G63920.1 topoisomerase 3alpha

9.0e-36

74.74

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Query:  GRPITVLNVAEKPSVAKSVATILSRNQGLRVREGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELDFEERYRKWHSCDPVQLFHAPIRKFVPE
        G P+TVLNVAEKPSVAKSVA ILSR    R REGRSRYNKIFEF+YAI GQ C ML+TSV GHLMEL+F +RYRKWHSCDP  L+ AP+ K VPE
Subjt:  GRPITVLNVAEKPSVAKSVATILSRNQGLRVREGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELDFEERYRKWHSCDPVQLFHAPIRKFVPE

Sequences

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CDS sequence

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ATGTCCAGCGGCCGTCCGATTACCGTCCTCAATGTGGCAGAGAAGCCATCGGTGGCGAAATCCGTGGCCACCATACTCTCCAGGAACCAGGGTCTTCGAGTTCGCGAAGG
TCGCTCTCGCTACAACAAGATTTTCGAGTTCAACTACGCCATTCGAGGCCAGTCTTGCAATATGCTCGTCACCTCCGTCACTGGCCACCTCATGGAGCTCGATTTTGAAG
AACGGTACCGGAAATGGCACTCCTGCGATCCAGTTCAGCTCTTCCACGCTCCCATCCGCAAATTTGTCCCCGAGTGGTCCTGGATCATCCTATCTCTGATCTTAGTTATG
GCCTTTTGGAAAGGTCTACAGTTAGGCCAATTTCCGCCTACGGCAAGTTTCAAGTGGCTGTTCTTGATTTTCGTCAGTGCATCTTCCTTTCGGGGTTACCACATCAGAGT
TGCAGTCGTTGAAGGTTTTCGCTTAACAACTAGCTGA

mRNA sequence

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Protein sequence

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MSSGRPITVLNVAEKPSVAKSVATILSRNQGLRVREGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELDFEERYRKWHSCDPVQLFHAPIRKFVPEWSWIILSLILVM
AFWKGLQLGQFPPTASFKWLFLIFVSASSFRGYHIRVAVVEGFRLTTS

HG10019912 (gene) of Bottle gourd (Hangzhou Gourd) v1 genome