CuGenDBv2

Gene ID	IVF0004425
Organism	Cucumis melo ssp. agrestis cv. IVF77 (Melon (IVF77) v1)
Description	ATP-dependent zinc metalloprotease FtsH
Genome location	chr02:11011983..11013509
RNA-Seq Expression	IVF0004425
Synteny	IVF0004425
Gene Ontology terms	GO:0006508 - proteolysis (biological process) GO:0042981 - regulation of apoptotic process (biological process) GO:0009534 - chloroplast thylakoid (cellular component) GO:0016021 - integral component of membrane (cellular component) GO:0004176 - ATP-dependent peptidase activity (molecular function) GO:0004222 - metalloendopeptidase activity (molecular function) GO:0005524 - ATP binding (molecular function) GO:0016887 - ATPase activity (molecular function)
InterPro domains	IPR003593 - AAA+ ATPase domain IPR003959 - ATPase, AAA-type, core IPR027417 - P-loop containing nucleoside triphosphate hydrolase

Homology

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GenBank top hits

e value

%identity

Alignment

TYK21958.1 putative inactive ATP-dependent zinc metalloprotease FTSHI 5 [Cucumis melo var. makuwa]

4.76e-55

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Query:  QGVLIVGERGTGKTSLALAIAAEAKVPVVTVEAQELEPGLWVGQSASNVRELFQTARDLAPVIIFVEDFDLFAGVRGKFIHTKEQDHEAFINQLLVELDG
        +GVLIVGERGTGKTSLALAIAAEAKVPVVTVEAQELEPGLWVGQSASNVRELFQTARDLAPVIIFVEDFDLFAGVRGKFIHTKEQDHEAFINQLLVELDG
Subjt:  QGVLIVGERGTGKTSLALAIAAEAKVPVVTVEAQELEPGLWVGQSASNVRELFQTARDLAPVIIFVEDFDLFAGVRGKFIHTKEQDHEAFINQLLVELDG

XP_006368058.1 PREDICTED: probable inactive ATP-dependent zinc metalloprotease FTSHI 5, chloroplastic, partial [Solanum tuberosum]

1.38e-56

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Query:  QGVLIVGERGTGKTSLALAIAAEAKVPVVTVEAQELEPGLWVGQSASNVRELFQTARDLAPVIIFVEDFDLFAGVRGKFIHTKEQDHEAFINQLLVELDG
        +GVLIVGERGTGKT+LALAIAAEAKVP+V V+AQ+LE GLWVGQSASNVRELFQTARDLAPVIIFVEDFDLFAGVRGKFIHTK+QDHEAFINQLLVELDG
Subjt:  QGVLIVGERGTGKTSLALAIAAEAKVPVVTVEAQELEPGLWVGQSASNVRELFQTARDLAPVIIFVEDFDLFAGVRGKFIHTKEQDHEAFINQLLVELDG

XP_008443775.1 PREDICTED: probable inactive ATP-dependent zinc metalloprotease FTSHI 5, chloroplastic [Cucumis melo]

5.90e-55

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Query:  QGVLIVGERGTGKTSLALAIAAEAKVPVVTVEAQELEPGLWVGQSASNVRELFQTARDLAPVIIFVEDFDLFAGVRGKFIHTKEQDHEAFINQLLVELDG
        +GVLIVGERGTGKTSLALAIAAEAKVPVVTVEAQELEPGLWVGQSASNVRELFQTARDLAPVIIFVEDFDLFAGVRGKFIHTKEQDHEAFINQLLVELDG
Subjt:  QGVLIVGERGTGKTSLALAIAAEAKVPVVTVEAQELEPGLWVGQSASNVRELFQTARDLAPVIIFVEDFDLFAGVRGKFIHTKEQDHEAFINQLLVELDG

XP_022158670.1 probable inactive ATP-dependent zinc metalloprotease FTSHI 5, chloroplastic [Momordica charantia]

5.90e-55

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Query:  QGVLIVGERGTGKTSLALAIAAEAKVPVVTVEAQELEPGLWVGQSASNVRELFQTARDLAPVIIFVEDFDLFAGVRGKFIHTKEQDHEAFINQLLVELDG
        +GVLIVGERGTGKTSLALAIAAEAKVPVVTVEAQELEPGLWVGQSASNVRELFQTARDLAPVIIFVEDFDLFAGVRGKFIHTKEQDHEAFINQLLVELDG
Subjt:  QGVLIVGERGTGKTSLALAIAAEAKVPVVTVEAQELEPGLWVGQSASNVRELFQTARDLAPVIIFVEDFDLFAGVRGKFIHTKEQDHEAFINQLLVELDG

XP_038878867.1 probable inactive ATP-dependent zinc metalloprotease FTSHI 5, chloroplastic [Benincasa hispida]

5.89e-55

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Query:  QGVLIVGERGTGKTSLALAIAAEAKVPVVTVEAQELEPGLWVGQSASNVRELFQTARDLAPVIIFVEDFDLFAGVRGKFIHTKEQDHEAFINQLLVELDG
        +GVLIVGERGTGKTSLALAIAAEAKVPVVTVEAQELEPGLWVGQSASNVRELFQTARDLAPVIIFVEDFDLFAGVRGKFIHTKEQDHEAFINQLLVELDG
Subjt:  QGVLIVGERGTGKTSLALAIAAEAKVPVVTVEAQELEPGLWVGQSASNVRELFQTARDLAPVIIFVEDFDLFAGVRGKFIHTKEQDHEAFINQLLVELDG

TrEMBL top hits

e value

%identity

Alignment

A0A0A0LY88 AAA domain-containing protein

1.4e-58

92.42

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Query:  MKYFLPSLDTTCSVAVFSKTIFISPHILSILFQGVLIVGERGTGKTSLALAIAAEAKVPVVTVEAQELEPGLWVGQSASNVRELFQTARDLAPVIIFVED
        +K+   SLDTTCSVAVFSKTI ISPH LSIL QGVLIVGE GTGKTSLALAIAAEAKVPVVTV+AQELEPGLWVGQSASNVRELFQTARDLAPVIIFVED
Subjt:  MKYFLPSLDTTCSVAVFSKTIFISPHILSILFQGVLIVGERGTGKTSLALAIAAEAKVPVVTVEAQELEPGLWVGQSASNVRELFQTARDLAPVIIFVED

Query:  FDLFAGVRGKFIHTKEQDHEAFINQLLVELDG
        FDLFAGVRGKFIHTKEQDHEAFINQLLVELDG
Subjt:  FDLFAGVRGKFIHTKEQDHEAFINQLLVELDG

A0A1S3B9K0 probable inactive ATP-dependent zinc metalloprotease FTSHI 5, chloroplastic

1.6e-46

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Query:  QGVLIVGERGTGKTSLALAIAAEAKVPVVTVEAQELEPGLWVGQSASNVRELFQTARDLAPVIIFVEDFDLFAGVRGKFIHTKEQDHEAFINQLLVELDG
        +GVLIVGERGTGKTSLALAIAAEAKVPVVTVEAQELEPGLWVGQSASNVRELFQTARDLAPVIIFVEDFDLFAGVRGKFIHTKEQDHEAFINQLLVELDG
Subjt:  QGVLIVGERGTGKTSLALAIAAEAKVPVVTVEAQELEPGLWVGQSASNVRELFQTARDLAPVIIFVEDFDLFAGVRGKFIHTKEQDHEAFINQLLVELDG

A0A5D3DES8 Putative inactive ATP-dependent zinc metalloprotease FTSHI 5

1.6e-46

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Query:  QGVLIVGERGTGKTSLALAIAAEAKVPVVTVEAQELEPGLWVGQSASNVRELFQTARDLAPVIIFVEDFDLFAGVRGKFIHTKEQDHEAFINQLLVELDG
        +GVLIVGERGTGKTSLALAIAAEAKVPVVTVEAQELEPGLWVGQSASNVRELFQTARDLAPVIIFVEDFDLFAGVRGKFIHTKEQDHEAFINQLLVELDG
Subjt:  QGVLIVGERGTGKTSLALAIAAEAKVPVVTVEAQELEPGLWVGQSASNVRELFQTARDLAPVIIFVEDFDLFAGVRGKFIHTKEQDHEAFINQLLVELDG

A0A6J1DWH2 probable inactive ATP-dependent zinc metalloprotease FTSHI 5, chloroplastic

1.6e-46

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Query:  QGVLIVGERGTGKTSLALAIAAEAKVPVVTVEAQELEPGLWVGQSASNVRELFQTARDLAPVIIFVEDFDLFAGVRGKFIHTKEQDHEAFINQLLVELDG
        +GVLIVGERGTGKTSLALAIAAEAKVPVVTVEAQELEPGLWVGQSASNVRELFQTARDLAPVIIFVEDFDLFAGVRGKFIHTKEQDHEAFINQLLVELDG
Subjt:  QGVLIVGERGTGKTSLALAIAAEAKVPVVTVEAQELEPGLWVGQSASNVRELFQTARDLAPVIIFVEDFDLFAGVRGKFIHTKEQDHEAFINQLLVELDG

A0A6J1JID9 probable inactive ATP-dependent zinc metalloprotease FTSHI 5, chloroplastic isoform X2

2.3e-45

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Query:  QGVLIVGERGTGKTSLALAIAAEAKVPVVTVEAQELEPGLWVGQSASNVRELFQTARDLAPVIIFVEDFDLFAGVRGKFIHTKEQDHEAFINQLLVELDG
        +GVLIVGERGTGKTSLA+AIAAEAKVPVVTV+AQELEPGLWVGQSASNVRELFQTARDLAPVIIFVEDFD+FAGVRGK+IHTKEQDHEAFINQLLVELDG
Subjt:  QGVLIVGERGTGKTSLALAIAAEAKVPVVTVEAQELEPGLWVGQSASNVRELFQTARDLAPVIIFVEDFDLFAGVRGKFIHTKEQDHEAFINQLLVELDG

SwissProt top hits

e value

%identity

Alignment

A1TZE0 ATP-dependent zinc metalloprotease FtsH

4.9e-16

43.27

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Query:  SILFQGVLIVGERGTGKTSLALAIAAEAKVPVVTVEAQELEPGLWVGQSASNVRELFQTARDLAPVIIFVEDFDLFAGVRGKFIHTKEQDHEAFINQLLV
        +++ +GVL+VG  GTGKT LA AIA EA+VP  ++ A E    ++VG  A+ VR++FQTAR  AP +IF+++ D     RG  +     + E  +NQ+L 
Subjt:  SILFQGVLIVGERGTGKTSLALAIAAEAKVPVVTVEAQELEPGLWVGQSASNVRELFQTARDLAPVIIFVEDFDLFAGVRGKFIHTKEQDHEAFINQLLV

Query:  ELDG
        E+DG
Subjt:  ELDG

A9NE17 ATP-dependent zinc metalloprotease FtsH

4.9e-16

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Query:  QGVLIVGERGTGKTSLALAIAAEAKVPVVTVEAQELEPGLWVGQSASNVRELFQTARDLAPVIIFVEDFDLFAGVRGKFIHTKEQDHEAFINQLLVELDG
        +GVL+VG+ GTGKT LA A+A EA+VP  ++   +    L+VG  AS VR+LF+ A+  AP IIF+++ D     RG  +     + E  +NQLLVE+DG
Subjt:  QGVLIVGERGTGKTSLALAIAAEAKVPVVTVEAQELEPGLWVGQSASNVRELFQTARDLAPVIIFVEDFDLFAGVRGKFIHTKEQDHEAFINQLLVELDG

B3DV46 ATP-dependent zinc metalloprotease FtsH 1

5.8e-17

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Query:  QGVLIVGERGTGKTSLALAIAAEAKVPVVTVEAQELEPGLWVGQSASNVRELFQTARDLAPVIIFVEDFDLFAGVRGKFIHTKEQDHEAFINQLLVELDG
        +GVL+VG  GTGKT LA A+A EAKVP  ++   E    ++VG  A+ VR+LF  A+  AP I+F+++ D     RG  I     +HE  +NQLLVE+DG
Subjt:  QGVLIVGERGTGKTSLALAIAAEAKVPVVTVEAQELEPGLWVGQSASNVRELFQTARDLAPVIIFVEDFDLFAGVRGKFIHTKEQDHEAFINQLLVELDG

F4J3N2 Probable inactive ATP-dependent zinc metalloprotease FTSHI 5, chloroplastic

4.6e-46

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Query:  QGVLIVGERGTGKTSLALAIAAEAKVPVVTVEAQELEPGLWVGQSASNVRELFQTARDLAPVIIFVEDFDLFAGVRGKFIHTKEQDHEAFINQLLVELDG
        +GVLIVGERGTGKTSLALAIAAEA+VPVV VEAQELE GLWVGQSA+NVRELFQTARDLAPVIIFVEDFDLFAGVRGKF+HTK+QDHE+FINQLLVELDG
Subjt:  QGVLIVGERGTGKTSLALAIAAEAKVPVVTVEAQELEPGLWVGQSASNVRELFQTARDLAPVIIFVEDFDLFAGVRGKFIHTKEQDHEAFINQLLVELDG

Q9SD67 ATP-dependent zinc metalloprotease FTSH 7, chloroplastic

6.4e-16

48.51

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Query:  QGVLIVGERGTGKTSLALAIAAEAKVPVVTVEAQELEPGLWVGQSASNVRELFQTARDLAPVIIFVEDFDLFAGVR-GKFIHTKEQDHEAFINQLLVELD
        +GVL+VG  GTGKT LA A+A EA+VP ++  A E    L+VG  AS VR+LF  A+  AP IIF+++ D  A  R GKF      + E  +NQLL E+D
Subjt:  QGVLIVGERGTGKTSLALAIAAEAKVPVVTVEAQELEPGLWVGQSASNVRELFQTARDLAPVIIFVEDFDLFAGVR-GKFIHTKEQDHEAFINQLLVELD

Query:  G
        G
Subjt:  G

Arabidopsis top hits

e value

%identity

Alignment

AT1G06430.1 FTSH protease 8

1.7e-16

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Query:  QGVLIVGERGTGKTSLALAIAAEAKVPVVTVEAQELEPGLWVGQSASNVRELFQTARDLAPVIIFVEDFDLFAGVRGKFIHTKEQDHEAFINQLLVELDG
        +GVL+VG  GTGKT LA AIA EA VP  ++   E    ++VG  AS VR+LF+ A++ AP I+FV++ D     RG  I     + E  +NQLL E+DG
Subjt:  QGVLIVGERGTGKTSLALAIAAEAKVPVVTVEAQELEPGLWVGQSASNVRELFQTARDLAPVIIFVEDFDLFAGVRGKFIHTKEQDHEAFINQLLVELDG

AT2G30950.1 FtsH extracellular protease family

2.3e-16

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Query:  QGVLIVGERGTGKTSLALAIAAEAKVPVVTVEAQELEPGLWVGQSASNVRELFQTARDLAPVIIFVEDFDLFAGVRGKFIHTKEQDHEAFINQLLVELDG
        +GVL++G  GTGKT LA AIA EA VP  ++   E    ++VG  AS VR+LF+ A++ AP I+FV++ D     RG  I     + E  +NQLL E+DG
Subjt:  QGVLIVGERGTGKTSLALAIAAEAKVPVVTVEAQELEPGLWVGQSASNVRELFQTARDLAPVIIFVEDFDLFAGVRGKFIHTKEQDHEAFINQLLVELDG

AT3G04340.1 FtsH extracellular protease family

3.2e-47

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Query:  QGVLIVGERGTGKTSLALAIAAEAKVPVVTVEAQELEPGLWVGQSASNVRELFQTARDLAPVIIFVEDFDLFAGVRGKFIHTKEQDHEAFINQLLVELDG
        +GVLIVGERGTGKTSLALAIAAEA+VPVV VEAQELE GLWVGQSA+NVRELFQTARDLAPVIIFVEDFDLFAGVRGKF+HTK+QDHE+FINQLLVELDG
Subjt:  QGVLIVGERGTGKTSLALAIAAEAKVPVVTVEAQELEPGLWVGQSASNVRELFQTARDLAPVIIFVEDFDLFAGVRGKFIHTKEQDHEAFINQLLVELDG

AT3G47060.1 FTSH protease 7

4.6e-17

48.51

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Query:  QGVLIVGERGTGKTSLALAIAAEAKVPVVTVEAQELEPGLWVGQSASNVRELFQTARDLAPVIIFVEDFDLFAGVR-GKFIHTKEQDHEAFINQLLVELD
        +GVL+VG  GTGKT LA A+A EA+VP ++  A E    L+VG  AS VR+LF  A+  AP IIF+++ D  A  R GKF      + E  +NQLL E+D
Subjt:  QGVLIVGERGTGKTSLALAIAAEAKVPVVTVEAQELEPGLWVGQSASNVRELFQTARDLAPVIIFVEDFDLFAGVR-GKFIHTKEQDHEAFINQLLVELD

Query:  G
        G
Subjt:  G

AT5G58870.1 FTSH protease 9

1.0e-16

47.52

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Query:  QGVLIVGERGTGKTSLALAIAAEAKVPVVTVEAQELEPGLWVGQSASNVRELFQTARDLAPVIIFVEDFDLFAGVR-GKFIHTKEQDHEAFINQLLVELD
        +GVL+VG  GTGKT LA A+A E+ VP ++  A E    L+VG  AS VR+LF  A+  AP IIF+++ D  A  R GKF      + E  +NQLL E+D
Subjt:  QGVLIVGERGTGKTSLALAIAAEAKVPVVTVEAQELEPGLWVGQSASNVRELFQTARDLAPVIIFVEDFDLFAGVR-GKFIHTKEQDHEAFINQLLVELD

Query:  G
        G
Subjt:  G

Sequences

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CDS sequence

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ATGAAATATTTCCTTCCATCCTTGGATACCACATGTTCAGTTGCAGTGTTTTCTAAAACAATTTTTATATCTCCTCATATTTTGAGCATCTTATTTCAGGGGGTTTTAAT
TGTTGGTGAGAGGGGAACAGGAAAGACATCTCTTGCACTGGCCATAGCTGCAGAAGCAAAAGTACCAGTTGTTACAGTTGAAGCCCAAGAATTAGAGCCTGGACTATGGG
TTGGGCAGAGTGCATCCAATGTCCGGGAATTATTCCAAACTGCAAGAGATTTGGCACCTGTTATCATATTTGTGGAGGATTTTGACCTCTTTGCTGGAGTTCGTGGCAAG
TTTATTCATACCAAAGAACAGGATCACGAGGCTTTCATTAACCAACTTCTTGTGGAGCTTGATGGGTAA

mRNA sequence

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Protein sequence

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MKYFLPSLDTTCSVAVFSKTIFISPHILSILFQGVLIVGERGTGKTSLALAIAAEAKVPVVTVEAQELEPGLWVGQSASNVRELFQTARDLAPVIIFVEDFDLFAGVRGK
FIHTKEQDHEAFINQLLVELDG

IVF0004425 (gene) of Melon (IVF77) v1 genome