CuGenDBv2

Gene ID	IVF0017102
Organism	Cucumis melo ssp. agrestis cv. IVF77 (Melon (IVF77) v1)
Description	endonuclease MutS2 isoform X1
Genome location	chr07:15692210..15695845
RNA-Seq Expression	IVF0017102
Synteny	IVF0017102
Gene Ontology terms	GO:0006298 - mismatch repair (biological process) GO:0045910 - negative regulation of DNA recombination (biological process) GO:0090305 - nucleic acid phosphodiester bond hydrolysis (biological process) GO:0004519 - endonuclease activity (molecular function) GO:0005524 - ATP binding (molecular function) GO:0016887 - ATPase activity (molecular function) GO:0030983 - mismatched DNA binding (molecular function)
InterPro domains	IPR045076 - DNA mismatch repair MutS family

Homology

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GenBank top hits

e value

%identity

Alignment

XP_004137269.1 uncharacterized protein LOC101220812 isoform X1 [Cucumis sativus]

5.49e-96

79.44

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Query:  RHPLTWTWISYSTLP--VPVISRNRAASLHFSLSANTPVSNDTSDNITQHSIRLDSLRALEWDKLCDSVASFARTSLGRQAIKAQLWSSNWTYEETW---
        RHPLTWTWISYSTLP  VPVI RNR ASLHFSLSAN  VSND  DN TQHSIRLDSLRALEWDKLCDSVASFARTSLGRQAIKAQLWSSNWTYEE+    
Subjt:  RHPLTWTWISYSTLP--VPVISRNRAASLHFSLSANTPVSNDTSDNITQHSIRLDSLRALEWDKLCDSVASFARTSLGRQAIKAQLWSSNWTYEETW---

Query:  -------------GCSLDLSGVDLNLVKSAIEHAQRSLPMDGNEAIAIAALLQ----------TAIKEDADWSTRFMPLTNVIMGMVVNQSLIKLILNAV
                     GCSLDLSGV+L+LVKSAIEHAQRSL MDGNEAIAIAALLQ          TAIKED DWSTRFMPLTNVIMGMVVNQSLIKLILNAV
Subjt:  -------------GCSLDLSGVDLNLVKSAIEHAQRSLPMDGNEAIAIAALLQ----------TAIKEDADWSTRFMPLTNVIMGMVVNQSLIKLILNAV

Query:  DEDGSVKDSAVCSL
        DEDGSVKDSA  +L
Subjt:  DEDGSVKDSAVCSL

XP_008462895.1 PREDICTED: endonuclease MutS2 isoform X1 [Cucumis melo]

2.13e-112

85.84

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Query:  MFCASLFRHPLTWTWISYSTLPVPVISRNRAASLHFSLSANTPVSNDTSDNITQHSIRLDSLRALEWDKLCDSVASFARTSLGRQAIKAQLWSSNWTYEE
        MFCASLFRHPLTWTWISYSTLPVPVISRNRAASLHFSLSANTPVSNDTSDNITQHSIRLDSLRALEWDKLCDSVASFARTSLGRQAIKAQLWSSNWTYEE
Subjt:  MFCASLFRHPLTWTWISYSTLPVPVISRNRAASLHFSLSANTPVSNDTSDNITQHSIRLDSLRALEWDKLCDSVASFARTSLGRQAIKAQLWSSNWTYEE

Query:  TW----------------GCSLDLSGVDLNLVKSAIEHAQRSLPMDGNEAIAIAALLQ----------TAIKEDADWSTRFMPLTNVIMGMVVNQSLIKL
        +                 GCSLDLSGVDLNLVKSAIEHAQRSLPMDGNEAIAIAALLQ          TAIKEDADWSTRFMPLTNVIMGMVVNQSLIKL
Subjt:  TW----------------GCSLDLSGVDLNLVKSAIEHAQRSLPMDGNEAIAIAALLQ----------TAIKEDADWSTRFMPLTNVIMGMVVNQSLIKL

Query:  ILNAVDEDGSVKDSAVCSL
        ILNAVDEDGSVKDSA  +L
Subjt:  ILNAVDEDGSVKDSAVCSL

XP_008462896.1 PREDICTED: endonuclease MutS2 isoform X2 [Cucumis melo]

2.08e-112

85.84

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Query:  MFCASLFRHPLTWTWISYSTLPVPVISRNRAASLHFSLSANTPVSNDTSDNITQHSIRLDSLRALEWDKLCDSVASFARTSLGRQAIKAQLWSSNWTYEE
        MFCASLFRHPLTWTWISYSTLPVPVISRNRAASLHFSLSANTPVSNDTSDNITQHSIRLDSLRALEWDKLCDSVASFARTSLGRQAIKAQLWSSNWTYEE
Subjt:  MFCASLFRHPLTWTWISYSTLPVPVISRNRAASLHFSLSANTPVSNDTSDNITQHSIRLDSLRALEWDKLCDSVASFARTSLGRQAIKAQLWSSNWTYEE

Query:  TW----------------GCSLDLSGVDLNLVKSAIEHAQRSLPMDGNEAIAIAALLQ----------TAIKEDADWSTRFMPLTNVIMGMVVNQSLIKL
        +                 GCSLDLSGVDLNLVKSAIEHAQRSLPMDGNEAIAIAALLQ          TAIKEDADWSTRFMPLTNVIMGMVVNQSLIKL
Subjt:  TW----------------GCSLDLSGVDLNLVKSAIEHAQRSLPMDGNEAIAIAALLQ----------TAIKEDADWSTRFMPLTNVIMGMVVNQSLIKL

Query:  ILNAVDEDGSVKDSAVCSL
        ILNAVDEDGSVKDSA  +L
Subjt:  ILNAVDEDGSVKDSAVCSL

XP_008462897.1 PREDICTED: endonuclease MutS2 isoform X3 [Cucumis melo]

1.26e-112

85.84

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Query:  MFCASLFRHPLTWTWISYSTLPVPVISRNRAASLHFSLSANTPVSNDTSDNITQHSIRLDSLRALEWDKLCDSVASFARTSLGRQAIKAQLWSSNWTYEE
        MFCASLFRHPLTWTWISYSTLPVPVISRNRAASLHFSLSANTPVSNDTSDNITQHSIRLDSLRALEWDKLCDSVASFARTSLGRQAIKAQLWSSNWTYEE
Subjt:  MFCASLFRHPLTWTWISYSTLPVPVISRNRAASLHFSLSANTPVSNDTSDNITQHSIRLDSLRALEWDKLCDSVASFARTSLGRQAIKAQLWSSNWTYEE

Query:  TW----------------GCSLDLSGVDLNLVKSAIEHAQRSLPMDGNEAIAIAALLQ----------TAIKEDADWSTRFMPLTNVIMGMVVNQSLIKL
        +                 GCSLDLSGVDLNLVKSAIEHAQRSLPMDGNEAIAIAALLQ          TAIKEDADWSTRFMPLTNVIMGMVVNQSLIKL
Subjt:  TW----------------GCSLDLSGVDLNLVKSAIEHAQRSLPMDGNEAIAIAALLQ----------TAIKEDADWSTRFMPLTNVIMGMVVNQSLIKL

Query:  ILNAVDEDGSVKDSAVCSL
        ILNAVDEDGSVKDSA  +L
Subjt:  ILNAVDEDGSVKDSAVCSL

XP_011653396.1 uncharacterized protein LOC101220812 isoform X2 [Cucumis sativus]

5.38e-96

79.44

Show/hide

Query:  RHPLTWTWISYSTLP--VPVISRNRAASLHFSLSANTPVSNDTSDNITQHSIRLDSLRALEWDKLCDSVASFARTSLGRQAIKAQLWSSNWTYEETW---
        RHPLTWTWISYSTLP  VPVI RNR ASLHFSLSAN  VSND  DN TQHSIRLDSLRALEWDKLCDSVASFARTSLGRQAIKAQLWSSNWTYEE+    
Subjt:  RHPLTWTWISYSTLP--VPVISRNRAASLHFSLSANTPVSNDTSDNITQHSIRLDSLRALEWDKLCDSVASFARTSLGRQAIKAQLWSSNWTYEETW---

Query:  -------------GCSLDLSGVDLNLVKSAIEHAQRSLPMDGNEAIAIAALLQ----------TAIKEDADWSTRFMPLTNVIMGMVVNQSLIKLILNAV
                     GCSLDLSGV+L+LVKSAIEHAQRSL MDGNEAIAIAALLQ          TAIKED DWSTRFMPLTNVIMGMVVNQSLIKLILNAV
Subjt:  -------------GCSLDLSGVDLNLVKSAIEHAQRSLPMDGNEAIAIAALLQ----------TAIKEDADWSTRFMPLTNVIMGMVVNQSLIKLILNAV

Query:  DEDGSVKDSAVCSL
        DEDGSVKDSA  +L
Subjt:  DEDGSVKDSAVCSL

TrEMBL top hits

e value

%identity

Alignment

A0A0A0KVU2 Uncharacterized protein

1.1e-80

77.83

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Query:  MFCASLFRHPLTWTWISYSTLP--VPVISRNRAASLHFSLSANTPVSNDTSDNITQHSIRLDSLRALEWDKLCDSVASFARTSLGRQAIKAQLWSSNWTY
        M C    RHPLTWTWISYSTLP  VPVI RNR ASLHFSLSAN  VSND  DN TQHSIRLDSLRALEWDKLCDSVASFARTSLGRQAIKAQLWSSNWTY
Subjt:  MFCASLFRHPLTWTWISYSTLP--VPVISRNRAASLHFSLSANTPVSNDTSDNITQHSIRLDSLRALEWDKLCDSVASFARTSLGRQAIKAQLWSSNWTY

Query:  EET----------------WGCSLDLSGVDLNLVKSAIEHAQRSLPMDGNEAIAIAALLQ----------TAIKEDADWSTRFMPLTNVIMGMVVNQSLI
        EE+                 GCSLDLSGV+L+LVKSAIEHAQRSL MDGNEAIAIAALLQ          TAIKED DWSTRFMPLTNVIMGMVVNQSLI
Subjt:  EET----------------WGCSLDLSGVDLNLVKSAIEHAQRSLPMDGNEAIAIAALLQ----------TAIKEDADWSTRFMPLTNVIMGMVVNQSLI

Query:  KLILNAVDEDGSVKDSAVCSL
        KLILNAVDEDGSVKDSA  +L
Subjt:  KLILNAVDEDGSVKDSAVCSL

A0A1S3CHX9 endonuclease MutS2 isoform X2

8.9e-94

85.84

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Query:  MFCASLFRHPLTWTWISYSTLPVPVISRNRAASLHFSLSANTPVSNDTSDNITQHSIRLDSLRALEWDKLCDSVASFARTSLGRQAIKAQLWSSNWTYEE
        MFCASLFRHPLTWTWISYSTLPVPVISRNRAASLHFSLSANTPVSNDTSDNITQHSIRLDSLRALEWDKLCDSVASFARTSLGRQAIKAQLWSSNWTYEE
Subjt:  MFCASLFRHPLTWTWISYSTLPVPVISRNRAASLHFSLSANTPVSNDTSDNITQHSIRLDSLRALEWDKLCDSVASFARTSLGRQAIKAQLWSSNWTYEE

Query:  T----------------WGCSLDLSGVDLNLVKSAIEHAQRSLPMDGNEAIAIAALLQ----------TAIKEDADWSTRFMPLTNVIMGMVVNQSLIKL
        +                 GCSLDLSGVDLNLVKSAIEHAQRSLPMDGNEAIAIAALLQ          TAIKEDADWSTRFMPLTNVIMGMVVNQSLIKL
Subjt:  T----------------WGCSLDLSGVDLNLVKSAIEHAQRSLPMDGNEAIAIAALLQ----------TAIKEDADWSTRFMPLTNVIMGMVVNQSLIKL

Query:  ILNAVDEDGSVKDSAVCSL
        ILNAVDEDGSVKDSA  +L
Subjt:  ILNAVDEDGSVKDSAVCSL

A0A1S3CHZ5 endonuclease MutS2 isoform X1

8.9e-94

85.84

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Query:  MFCASLFRHPLTWTWISYSTLPVPVISRNRAASLHFSLSANTPVSNDTSDNITQHSIRLDSLRALEWDKLCDSVASFARTSLGRQAIKAQLWSSNWTYEE
        MFCASLFRHPLTWTWISYSTLPVPVISRNRAASLHFSLSANTPVSNDTSDNITQHSIRLDSLRALEWDKLCDSVASFARTSLGRQAIKAQLWSSNWTYEE
Subjt:  MFCASLFRHPLTWTWISYSTLPVPVISRNRAASLHFSLSANTPVSNDTSDNITQHSIRLDSLRALEWDKLCDSVASFARTSLGRQAIKAQLWSSNWTYEE

Query:  T----------------WGCSLDLSGVDLNLVKSAIEHAQRSLPMDGNEAIAIAALLQ----------TAIKEDADWSTRFMPLTNVIMGMVVNQSLIKL
        +                 GCSLDLSGVDLNLVKSAIEHAQRSLPMDGNEAIAIAALLQ          TAIKEDADWSTRFMPLTNVIMGMVVNQSLIKL
Subjt:  T----------------WGCSLDLSGVDLNLVKSAIEHAQRSLPMDGNEAIAIAALLQ----------TAIKEDADWSTRFMPLTNVIMGMVVNQSLIKL

Query:  ILNAVDEDGSVKDSAVCSL
        ILNAVDEDGSVKDSA  +L
Subjt:  ILNAVDEDGSVKDSAVCSL

A0A1S3CIG3 endonuclease MutS2 isoform X3

8.9e-94

85.84

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Query:  MFCASLFRHPLTWTWISYSTLPVPVISRNRAASLHFSLSANTPVSNDTSDNITQHSIRLDSLRALEWDKLCDSVASFARTSLGRQAIKAQLWSSNWTYEE
        MFCASLFRHPLTWTWISYSTLPVPVISRNRAASLHFSLSANTPVSNDTSDNITQHSIRLDSLRALEWDKLCDSVASFARTSLGRQAIKAQLWSSNWTYEE
Subjt:  MFCASLFRHPLTWTWISYSTLPVPVISRNRAASLHFSLSANTPVSNDTSDNITQHSIRLDSLRALEWDKLCDSVASFARTSLGRQAIKAQLWSSNWTYEE

Query:  T----------------WGCSLDLSGVDLNLVKSAIEHAQRSLPMDGNEAIAIAALLQ----------TAIKEDADWSTRFMPLTNVIMGMVVNQSLIKL
        +                 GCSLDLSGVDLNLVKSAIEHAQRSLPMDGNEAIAIAALLQ          TAIKEDADWSTRFMPLTNVIMGMVVNQSLIKL
Subjt:  T----------------WGCSLDLSGVDLNLVKSAIEHAQRSLPMDGNEAIAIAALLQ----------TAIKEDADWSTRFMPLTNVIMGMVVNQSLIKL

Query:  ILNAVDEDGSVKDSAVCSL
        ILNAVDEDGSVKDSA  +L
Subjt:  ILNAVDEDGSVKDSAVCSL

A0A5D3BZK6 Endonuclease MutS2 isoform X1

8.9e-94

85.84

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Query:  MFCASLFRHPLTWTWISYSTLPVPVISRNRAASLHFSLSANTPVSNDTSDNITQHSIRLDSLRALEWDKLCDSVASFARTSLGRQAIKAQLWSSNWTYEE
        MFCASLFRHPLTWTWISYSTLPVPVISRNRAASLHFSLSANTPVSNDTSDNITQHSIRLDSLRALEWDKLCDSVASFARTSLGRQAIKAQLWSSNWTYEE
Subjt:  MFCASLFRHPLTWTWISYSTLPVPVISRNRAASLHFSLSANTPVSNDTSDNITQHSIRLDSLRALEWDKLCDSVASFARTSLGRQAIKAQLWSSNWTYEE

Query:  T----------------WGCSLDLSGVDLNLVKSAIEHAQRSLPMDGNEAIAIAALLQ----------TAIKEDADWSTRFMPLTNVIMGMVVNQSLIKL
        +                 GCSLDLSGVDLNLVKSAIEHAQRSLPMDGNEAIAIAALLQ          TAIKEDADWSTRFMPLTNVIMGMVVNQSLIKL
Subjt:  T----------------WGCSLDLSGVDLNLVKSAIEHAQRSLPMDGNEAIAIAALLQ----------TAIKEDADWSTRFMPLTNVIMGMVVNQSLIKL

Query:  ILNAVDEDGSVKDSAVCSL
        ILNAVDEDGSVKDSA  +L
Subjt:  ILNAVDEDGSVKDSAVCSL

SwissProt top hits	e value	%identity	Alignment
No hits found

Arabidopsis top hits

e value

%identity

Alignment

AT5G54090.1 DNA mismatch repair protein MutS, type 2

6.2e-31

40.93

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Query:  SRNRAASLHFSLSANTPVSNDTSDNITQHSIRLDSLRALEWDKLCDSVASFARTSLGRQAIKAQLWSSNWTYEET----------------WGCSLDLSG
        +RNR      S S+ T V +  S + T      DSLR LEWDKLCD VASFARTSLGR+A K +LWS + ++ E+                    LDLS 
Subjt:  SRNRAASLHFSLSANTPVSNDTSDNITQHSIRLDSLRALEWDKLCDSVASFARTSLGRQAIKAQLWSSNWTYEET----------------WGCSLDLSG

Query:  VDLNLVKSAIEHAQRSLPMDGNEAIAIAAL----------LQTAIKEDADWSTRFMPLTNVIMGMVVNQSLIKLILNAVDEDGSVKDSAVCSL
        + ++LV+S I HA+R L +  ++A+ +A+L          L+ AIK+D DW  RFMPL+ +I+  V+N+S +KL+   +D DG++KDSA  +L
Subjt:  VDLNLVKSAIEHAQRSLPMDGNEAIAIAAL----------LQTAIKEDADWSTRFMPLTNVIMGMVVNQSLIKLILNAVDEDGSVKDSAVCSL

Sequences

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CDS sequence

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ATGTTCTGTGCATCTCTTTTCCGGCATCCCCTCACCTGGACCTGGATCAGCTATTCTACACTGCCGGTGCCGGTTATATCCCGGAATCGAGCTGCGTCCCTACACTTCTC
CCTCTCTGCAAACACTCCCGTCAGCAATGACACTAGTGATAACATAACCCAACATTCAATCCGCCTGGACAGTCTCAGAGCGCTAGAATGGGATAAGCTTTGCGATTCAG
TTGCTTCCTTCGCGCGCACTTCTCTGGGGCGTCAAGCTATCAAGGCCCAACTTTGGTCTTCGAACTGGACATATGAAGAAACATGGGGCTGCAGCTTAGATTTAAGTGGC
GTCGACCTTAATCTGGTGAAATCGGCAATAGAACATGCTCAAAGGAGTCTGCCAATGGATGGAAATGAAGCAATAGCTATTGCAGCTCTTCTACAAACAGCAATCAAAGA
AGATGCTGATTGGTCTACACGTTTTATGCCTCTAACAAACGTGATAATGGGAATGGTTGTAAATCAATCATTGATTAAACTGATACTGAATGCTGTAGATGAAGATGGCT
CGGTTAAAGATTCTGCGGTTTGCTCCTTATAA

mRNA sequence

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Protein sequence

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MFCASLFRHPLTWTWISYSTLPVPVISRNRAASLHFSLSANTPVSNDTSDNITQHSIRLDSLRALEWDKLCDSVASFARTSLGRQAIKAQLWSSNWTYEETWGCSLDLSG
VDLNLVKSAIEHAQRSLPMDGNEAIAIAALLQTAIKEDADWSTRFMPLTNVIMGMVVNQSLIKLILNAVDEDGSVKDSAVCSL

IVF0017102 (gene) of Melon (IVF77) v1 genome