CuGenDBv2

Gene ID	IVF0024332
Organism	Cucumis melo ssp. agrestis cv. IVF77 (Melon (IVF77) v1)
Description	Omega-protein
Genome location	chr04:2391945..2398965
RNA-Seq Expression	IVF0024332
Synteny	IVF0024332
Gene Ontology terms	GO:0006265 - DNA topological change (biological process) GO:0005694 - chromosome (cellular component) GO:0003677 - DNA binding (molecular function) GO:0003729 - mRNA binding (molecular function) GO:0003917 - DNA topoisomerase type I activity (molecular function) GO:0046872 - metal ion binding (molecular function)
InterPro domains	IPR000380 - DNA topoisomerase, type IA IPR013497 - DNA topoisomerase, type IA, central IPR013498 - DNA topoisomerase, type IA, zn finger IPR013824 - DNA topoisomerase, type IA, central region, subdomain 1 IPR023405 - DNA topoisomerase, type IA, core domain IPR025589 - Topoisomerase C-terminal repeat

Homology

Show/hide homology

GenBank top hits

e value

%identity

Alignment

KAA0038737.1 DNA topoisomerase 1 isoform X2 [Cucumis melo var. makuwa]

1.81e-214

100

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Query:  MEELGIGRPSTYATTLKVLKDRKYVSVKSRVLHPEFRGRMVSAFLSHHFSEVTDYSFTADMENELDNVSAGLTEWKGLLRDYWTRFSSYFERVNSVHIHQ
        MEELGIGRPSTYATTLKVLKDRKYVSVKSRVLHPEFRGRMVSAFLSHHFSEVTDYSFTADMENELDNVSAGLTEWKGLLRDYWTRFSSYFERVNSVHIHQ
Subjt:  MEELGIGRPSTYATTLKVLKDRKYVSVKSRVLHPEFRGRMVSAFLSHHFSEVTDYSFTADMENELDNVSAGLTEWKGLLRDYWTRFSSYFERVNSVHIHQ

Query:  VEKMLEKKYGDFLFSFLPDNSRACPSCQEGTLIFKLSRFGPGYFIGCDQHPRCKHIAKTLHGEDEDNDNSFKEPKLLGLHPDLNEKILLKKGPFGFYVQL
        VEKMLEKKYGDFLFSFLPDNSRACPSCQEGTLIFKLSRFGPGYFIGCDQHPRCKHIAKTLHGEDEDNDNSFKEPKLLGLHPDLNEKILLKKGPFGFYVQL
Subjt:  VEKMLEKKYGDFLFSFLPDNSRACPSCQEGTLIFKLSRFGPGYFIGCDQHPRCKHIAKTLHGEDEDNDNSFKEPKLLGLHPDLNEKILLKKGPFGFYVQL

Query:  GEDRKGFLPKRASLSQIKDVSSITLEDAVERLCYPVTLGKHPKDGEPVIIKMARVGFAVGHRRTTASIPENLKPNDIDLAKALELLSSSSIRRSGRSKSN
        GEDRKGFLPKRASLSQIKDVSSITLEDAVERLCYPVTLGKHPKDGEPVIIKMARVGFAVGHRRTTASIPENLKPNDIDLAKALELLSSSSIRRSGRSKSN
Subjt:  GEDRKGFLPKRASLSQIKDVSSITLEDAVERLCYPVTLGKHPKDGEPVIIKMARVGFAVGHRRTTASIPENLKPNDIDLAKALELLSSSSIRRSGRSKSN

Query:  PKVASC
        PKVASC
Subjt:  PKVASC

XP_011652536.2 uncharacterized protein LOC101210581 isoform X1 [Cucumis sativus]

5.74e-197

91.18

Show/hide

Query:  MEELGIGRPSTYATTLKVLKDRKYVSVKSRVLHPEFRGRMVSAFLSHHFSEVTDYSFTADMENELDNVSAGLTEWKGLLRDYWTRFSSYFERVNSVHIHQ
        MEELGIGRPSTYATT+KVL+DRKYVSVKSRVLHPEFRGRMVSAFL HHFSEVTDYSFTADMENELDNVSAGLTEWKGLLRDYWTRFSSYFE VNSVHIHQ
Subjt:  MEELGIGRPSTYATTLKVLKDRKYVSVKSRVLHPEFRGRMVSAFLSHHFSEVTDYSFTADMENELDNVSAGLTEWKGLLRDYWTRFSSYFERVNSVHIHQ

Query:  VEKMLEKKYGDFLFSFLPDNSRACPSCQEGTLIFKLSRFGPGYFIGCDQHPRCKHIAKTLHGEDEDNDNSFKEPKLLGLHPDLNEKILLKKGPFGFYVQL
        VEKMLEKKYG F+FSFLPDNSR CPSCQEGTL FKLSRFG GYF+GCDQHP+CK+IAKT HGEDEDNDNS KEPKLLGLHPDLNEKILLKKGPFG YVQL
Subjt:  VEKMLEKKYGDFLFSFLPDNSRACPSCQEGTLIFKLSRFGPGYFIGCDQHPRCKHIAKTLHGEDEDNDNSFKEPKLLGLHPDLNEKILLKKGPFGFYVQL

Query:  GEDRKGFLPKRASLSQIKDVSSITLEDAVERLCYPVTLGKHPKDGEPVIIKMARVGFAVGHRRTTASIPENLKPNDIDLAKALELLSSSSIRRSGRSKSN
        GEDRKG+LPKRASLSQIKDV+SITLEDAVERLCYPVTLG HPKDG+PVIIKMARVGFAVGH RT AS+PENLKPND+DLAKALELLSSS++RRSGRSK  
Subjt:  GEDRKGFLPKRASLSQIKDVSSITLEDAVERLCYPVTLGKHPKDGEPVIIKMARVGFAVGHRRTTASIPENLKPNDIDLAKALELLSSSSIRRSGRSKSN

Query:  PKVASC
        PKVASC
Subjt:  PKVASC

XP_016903546.1 PREDICTED: DNA topoisomerase 1 isoform X2 [Cucumis melo]

5.73e-213

100

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Query:  MEELGIGRPSTYATTLKVLKDRKYVSVKSRVLHPEFRGRMVSAFLSHHFSEVTDYSFTADMENELDNVSAGLTEWKGLLRDYWTRFSSYFERVNSVHIHQ
        MEELGIGRPSTYATTLKVLKDRKYVSVKSRVLHPEFRGRMVSAFLSHHFSEVTDYSFTADMENELDNVSAGLTEWKGLLRDYWTRFSSYFERVNSVHIHQ
Subjt:  MEELGIGRPSTYATTLKVLKDRKYVSVKSRVLHPEFRGRMVSAFLSHHFSEVTDYSFTADMENELDNVSAGLTEWKGLLRDYWTRFSSYFERVNSVHIHQ

Query:  VEKMLEKKYGDFLFSFLPDNSRACPSCQEGTLIFKLSRFGPGYFIGCDQHPRCKHIAKTLHGEDEDNDNSFKEPKLLGLHPDLNEKILLKKGPFGFYVQL
        VEKMLEKKYGDFLFSFLPDNSRACPSCQEGTLIFKLSRFGPGYFIGCDQHPRCKHIAKTLHGEDEDNDNSFKEPKLLGLHPDLNEKILLKKGPFGFYVQL
Subjt:  VEKMLEKKYGDFLFSFLPDNSRACPSCQEGTLIFKLSRFGPGYFIGCDQHPRCKHIAKTLHGEDEDNDNSFKEPKLLGLHPDLNEKILLKKGPFGFYVQL

Query:  GEDRKGFLPKRASLSQIKDVSSITLEDAVERLCYPVTLGKHPKDGEPVIIKMARVGFAVGHRRTTASIPENLKPNDIDLAKALELLSSSSIRRSGRSKSN
        GEDRKGFLPKRASLSQIKDVSSITLEDAVERLCYPVTLGKHPKDGEPVIIKMARVGFAVGHRRTTASIPENLKPNDIDLAKALELLSSSSIRRSGRSKSN
Subjt:  GEDRKGFLPKRASLSQIKDVSSITLEDAVERLCYPVTLGKHPKDGEPVIIKMARVGFAVGHRRTTASIPENLKPNDIDLAKALELLSSSSIRRSGRSKSN

Query:  PKVASC
        PKVASC
Subjt:  PKVASC

XP_022144286.1 uncharacterized protein LOC111013976 [Momordica charantia]

5.22e-171

82.08

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Query:  MEELGIGRPSTYATTLKVLKDRKYVSVKSRVLHPEFRGRMVSAFLSHHFSEVTDYSFTADMENELDNVSAGLTEWKGLLRDYWTRFSSYFERVNSVHIHQ
        MEELGIGRPSTYATTLKVL+DR YVSVKSRVLHPEFRGRMVSAFL HHFSEVTDYSFTADME ELDNVSAGLTEWKGLLRDYWTRFSSY E  NSVHIHQ
Subjt:  MEELGIGRPSTYATTLKVLKDRKYVSVKSRVLHPEFRGRMVSAFLSHHFSEVTDYSFTADMENELDNVSAGLTEWKGLLRDYWTRFSSYFERVNSVHIHQ

Query:  VEKMLEKKYGDFLFSFLPDNSRACPSCQEGTLIFKLSRFGPGYFIGCDQHPRCKHIAKTLHGEDED----NDNSFKEPKLLGLHPDLNEKILLKKGPFGF
        VEKMLEKK+GDFLFSFLPDN R CPSC EGTLIFK+SRFG GYFIGCDQHP+CK+IAKTL+GEDE+    N+NS +EPKLLGLHP  NEKILLK GP+GF
Subjt:  VEKMLEKKYGDFLFSFLPDNSRACPSCQEGTLIFKLSRFGPGYFIGCDQHPRCKHIAKTLHGEDED----NDNSFKEPKLLGLHPDLNEKILLKKGPFGF

Query:  YVQLGEDRKGFLPKRASLSQIKDVSSITLEDAVERLCYPVTLGKHPKDGEPVIIKMARVGFAVGHRRTTASIPENLKPNDIDLAKALELLSSSSIRRSGR
        YVQLGEDRKG+LPKRAS+SQIK V SITLEDA+E L YP+TLG HPKDG+PVIIK+A+ GF+V HRRT A+IP+NLKPN I L KALELLSS+ +RR GR
Subjt:  YVQLGEDRKGFLPKRASLSQIKDVSSITLEDAVERLCYPVTLGKHPKDGEPVIIKMARVGFAVGHRRTTASIPENLKPNDIDLAKALELLSSSSIRRSGR

Query:  SKSNPKV
         KS PKV
Subjt:  SKSNPKV

XP_031737510.1 uncharacterized protein LOC101210581 isoform X2 [Cucumis sativus]

3.90e-201

91.18

Show/hide

Query:  MEELGIGRPSTYATTLKVLKDRKYVSVKSRVLHPEFRGRMVSAFLSHHFSEVTDYSFTADMENELDNVSAGLTEWKGLLRDYWTRFSSYFERVNSVHIHQ
        MEELGIGRPSTYATT+KVL+DRKYVSVKSRVLHPEFRGRMVSAFL HHFSEVTDYSFTADMENELDNVSAGLTEWKGLLRDYWTRFSSYFE VNSVHIHQ
Subjt:  MEELGIGRPSTYATTLKVLKDRKYVSVKSRVLHPEFRGRMVSAFLSHHFSEVTDYSFTADMENELDNVSAGLTEWKGLLRDYWTRFSSYFERVNSVHIHQ

Query:  VEKMLEKKYGDFLFSFLPDNSRACPSCQEGTLIFKLSRFGPGYFIGCDQHPRCKHIAKTLHGEDEDNDNSFKEPKLLGLHPDLNEKILLKKGPFGFYVQL
        VEKMLEKKYG F+FSFLPDNSR CPSCQEGTL FKLSRFG GYF+GCDQHP+CK+IAKT HGEDEDNDNS KEPKLLGLHPDLNEKILLKKGPFG YVQL
Subjt:  VEKMLEKKYGDFLFSFLPDNSRACPSCQEGTLIFKLSRFGPGYFIGCDQHPRCKHIAKTLHGEDEDNDNSFKEPKLLGLHPDLNEKILLKKGPFGFYVQL

Query:  GEDRKGFLPKRASLSQIKDVSSITLEDAVERLCYPVTLGKHPKDGEPVIIKMARVGFAVGHRRTTASIPENLKPNDIDLAKALELLSSSSIRRSGRSKSN
        GEDRKG+LPKRASLSQIKDV+SITLEDAVERLCYPVTLG HPKDG+PVIIKMARVGFAVGH RT AS+PENLKPND+DLAKALELLSSS++RRSGRSK  
Subjt:  GEDRKGFLPKRASLSQIKDVSSITLEDAVERLCYPVTLGKHPKDGEPVIIKMARVGFAVGHRRTTASIPENLKPNDIDLAKALELLSSSSIRRSGRSKSN

Query:  PKVASC
        PKVASC
Subjt:  PKVASC

TrEMBL top hits

e value

%identity

Alignment

A0A1S4E5M8 Omega-protein

1.0e-176

100

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Query:  MEELGIGRPSTYATTLKVLKDRKYVSVKSRVLHPEFRGRMVSAFLSHHFSEVTDYSFTADMENELDNVSAGLTEWKGLLRDYWTRFSSYFERVNSVHIHQ
        MEELGIGRPSTYATTLKVLKDRKYVSVKSRVLHPEFRGRMVSAFLSHHFSEVTDYSFTADMENELDNVSAGLTEWKGLLRDYWTRFSSYFERVNSVHIHQ
Subjt:  MEELGIGRPSTYATTLKVLKDRKYVSVKSRVLHPEFRGRMVSAFLSHHFSEVTDYSFTADMENELDNVSAGLTEWKGLLRDYWTRFSSYFERVNSVHIHQ

Query:  VEKMLEKKYGDFLFSFLPDNSRACPSCQEGTLIFKLSRFGPGYFIGCDQHPRCKHIAKTLHGEDEDNDNSFKEPKLLGLHPDLNEKILLKKGPFGFYVQL
        VEKMLEKKYGDFLFSFLPDNSRACPSCQEGTLIFKLSRFGPGYFIGCDQHPRCKHIAKTLHGEDEDNDNSFKEPKLLGLHPDLNEKILLKKGPFGFYVQL
Subjt:  VEKMLEKKYGDFLFSFLPDNSRACPSCQEGTLIFKLSRFGPGYFIGCDQHPRCKHIAKTLHGEDEDNDNSFKEPKLLGLHPDLNEKILLKKGPFGFYVQL

Query:  GEDRKGFLPKRASLSQIKDVSSITLEDAVERLCYPVTLGKHPKDGEPVIIKMARVGFAVGHRRTTASIPENLKPNDIDLAKALELLSSSSIRRSGRSKSN
        GEDRKGFLPKRASLSQIKDVSSITLEDAVERLCYPVTLGKHPKDGEPVIIKMARVGFAVGHRRTTASIPENLKPNDIDLAKALELLSSSSIRRSGRSKSN
Subjt:  GEDRKGFLPKRASLSQIKDVSSITLEDAVERLCYPVTLGKHPKDGEPVIIKMARVGFAVGHRRTTASIPENLKPNDIDLAKALELLSSSSIRRSGRSKSN

Query:  PKVASC
        PKVASC
Subjt:  PKVASC

A0A5A7TAX8 Omega-protein

1.0e-176

100

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Query:  MEELGIGRPSTYATTLKVLKDRKYVSVKSRVLHPEFRGRMVSAFLSHHFSEVTDYSFTADMENELDNVSAGLTEWKGLLRDYWTRFSSYFERVNSVHIHQ
        MEELGIGRPSTYATTLKVLKDRKYVSVKSRVLHPEFRGRMVSAFLSHHFSEVTDYSFTADMENELDNVSAGLTEWKGLLRDYWTRFSSYFERVNSVHIHQ
Subjt:  MEELGIGRPSTYATTLKVLKDRKYVSVKSRVLHPEFRGRMVSAFLSHHFSEVTDYSFTADMENELDNVSAGLTEWKGLLRDYWTRFSSYFERVNSVHIHQ

Query:  VEKMLEKKYGDFLFSFLPDNSRACPSCQEGTLIFKLSRFGPGYFIGCDQHPRCKHIAKTLHGEDEDNDNSFKEPKLLGLHPDLNEKILLKKGPFGFYVQL
        VEKMLEKKYGDFLFSFLPDNSRACPSCQEGTLIFKLSRFGPGYFIGCDQHPRCKHIAKTLHGEDEDNDNSFKEPKLLGLHPDLNEKILLKKGPFGFYVQL
Subjt:  VEKMLEKKYGDFLFSFLPDNSRACPSCQEGTLIFKLSRFGPGYFIGCDQHPRCKHIAKTLHGEDEDNDNSFKEPKLLGLHPDLNEKILLKKGPFGFYVQL

Query:  GEDRKGFLPKRASLSQIKDVSSITLEDAVERLCYPVTLGKHPKDGEPVIIKMARVGFAVGHRRTTASIPENLKPNDIDLAKALELLSSSSIRRSGRSKSN
        GEDRKGFLPKRASLSQIKDVSSITLEDAVERLCYPVTLGKHPKDGEPVIIKMARVGFAVGHRRTTASIPENLKPNDIDLAKALELLSSSSIRRSGRSKSN
Subjt:  GEDRKGFLPKRASLSQIKDVSSITLEDAVERLCYPVTLGKHPKDGEPVIIKMARVGFAVGHRRTTASIPENLKPNDIDLAKALELLSSSSIRRSGRSKSN

Query:  PKVASC
        PKVASC
Subjt:  PKVASC

A0A6J1CSY4 Omega-protein

1.1e-143

82.08

Show/hide

Query:  MEELGIGRPSTYATTLKVLKDRKYVSVKSRVLHPEFRGRMVSAFLSHHFSEVTDYSFTADMENELDNVSAGLTEWKGLLRDYWTRFSSYFERVNSVHIHQ
        MEELGIGRPSTYATTLKVL+DR YVSVKSRVLHPEFRGRMVSAFL HHFSEVTDYSFTADME ELDNVSAGLTEWKGLLRDYWTRFSSY E  NSVHIHQ
Subjt:  MEELGIGRPSTYATTLKVLKDRKYVSVKSRVLHPEFRGRMVSAFLSHHFSEVTDYSFTADMENELDNVSAGLTEWKGLLRDYWTRFSSYFERVNSVHIHQ

Query:  VEKMLEKKYGDFLFSFLPDNSRACPSCQEGTLIFKLSRFGPGYFIGCDQHPRCKHIAKTLHGEDED----NDNSFKEPKLLGLHPDLNEKILLKKGPFGF
        VEKMLEKK+GDFLFSFLPDN R CPSC EGTLIFK+SRFG GYFIGCDQHP+CK+IAKTL+GEDE+    N+NS +EPKLLGLHP  NEKILLK GP+GF
Subjt:  VEKMLEKKYGDFLFSFLPDNSRACPSCQEGTLIFKLSRFGPGYFIGCDQHPRCKHIAKTLHGEDED----NDNSFKEPKLLGLHPDLNEKILLKKGPFGF

Query:  YVQLGEDRKGFLPKRASLSQIKDVSSITLEDAVERLCYPVTLGKHPKDGEPVIIKMARVGFAVGHRRTTASIPENLKPNDIDLAKALELLSSSSIRRSGR
        YVQLGEDRKG+LPKRAS+SQIK V SITLEDA+E L YP+TLG HPKDG+PVIIK+A+ GF+V HRRT A+IP+NLKPN I L KALELLSS+ +RR GR
Subjt:  YVQLGEDRKGFLPKRASLSQIKDVSSITLEDAVERLCYPVTLGKHPKDGEPVIIKMARVGFAVGHRRTTASIPENLKPNDIDLAKALELLSSSSIRRSGR

Query:  SKSNPKV
         KS PKV
Subjt:  SKSNPKV

A0A6J1IF86 Omega-protein

4.8e-142

79.87

Show/hide

Query:  MEELGIGRPSTYATTLKVLKDRKYVSVKSRVLHPEFRGRMVSAFLSHHFSEVTDYSFTADMENELDNVSAGLTEWKGLLRDYWTRFSSYFERVNSVHIHQ
        MEELGIGRPSTYA+TLKVL+DR Y+SVKSRVLHPEFRGRMVSAFL HHFSEVTDYSFTADMENELDNVSAGLTEWKGLLRDYWTRFS+Y ER N+VHIHQ
Subjt:  MEELGIGRPSTYATTLKVLKDRKYVSVKSRVLHPEFRGRMVSAFLSHHFSEVTDYSFTADMENELDNVSAGLTEWKGLLRDYWTRFSSYFERVNSVHIHQ

Query:  VEKMLEKKYGDFLFSFLPDNSRACPSCQEGTLIFKLSRFGPGYFIGCDQHPRCKHIAKTLHGEDED-----NDNSFKEPKLLGLHPDLNEKILLKKGPFG
        VEKMLEKKY DFLFSFLPDN R CPSC EGTLIFK+SR+G GYFIGCDQHPRCK+IAKTL+GEDE+     N+ S +EPKLLGLHP  +EKILLK GP+G
Subjt:  VEKMLEKKYGDFLFSFLPDNSRACPSCQEGTLIFKLSRFGPGYFIGCDQHPRCKHIAKTLHGEDED-----NDNSFKEPKLLGLHPDLNEKILLKKGPFG

Query:  FYVQLGEDRKGFLPKRASLSQIKDVSSITLEDAVERLCYPVTLGKHPKDGEPVIIKMARVGFAVGHRRTTASIPENLKPNDIDLAKALELLSSSSIRRSG
        FYVQLGEDRKG++PKR S+SQIKDV SITLEDA+E L YP+TLG HPKDG  V+IK+ + GF V HRRT AS+P+NLKPND+DLAKALELLSS  +RR G
Subjt:  FYVQLGEDRKGFLPKRASLSQIKDVSSITLEDAVERLCYPVTLGKHPKDGEPVIIKMARVGFAVGHRRTTASIPENLKPNDIDLAKALELLSSSSIRRSG

Query:  RSKSNPKV
        R KS PKV
Subjt:  RSKSNPKV

A0A6J1IMZ7 Omega-protein

4.8e-142

79.87

Show/hide

Query:  MEELGIGRPSTYATTLKVLKDRKYVSVKSRVLHPEFRGRMVSAFLSHHFSEVTDYSFTADMENELDNVSAGLTEWKGLLRDYWTRFSSYFERVNSVHIHQ
        MEELGIGRPSTYA+TLKVL+DR Y+SVKSRVLHPEFRGRMVSAFL HHFSEVTDYSFTADMENELDNVSAGLTEWKGLLRDYWTRFS+Y ER N+VHIHQ
Subjt:  MEELGIGRPSTYATTLKVLKDRKYVSVKSRVLHPEFRGRMVSAFLSHHFSEVTDYSFTADMENELDNVSAGLTEWKGLLRDYWTRFSSYFERVNSVHIHQ

Query:  VEKMLEKKYGDFLFSFLPDNSRACPSCQEGTLIFKLSRFGPGYFIGCDQHPRCKHIAKTLHGEDED-----NDNSFKEPKLLGLHPDLNEKILLKKGPFG
        VEKMLEKKY DFLFSFLPDN R CPSC EGTLIFK+SR+G GYFIGCDQHPRCK+IAKTL+GEDE+     N+ S +EPKLLGLHP  +EKILLK GP+G
Subjt:  VEKMLEKKYGDFLFSFLPDNSRACPSCQEGTLIFKLSRFGPGYFIGCDQHPRCKHIAKTLHGEDED-----NDNSFKEPKLLGLHPDLNEKILLKKGPFG

Query:  FYVQLGEDRKGFLPKRASLSQIKDVSSITLEDAVERLCYPVTLGKHPKDGEPVIIKMARVGFAVGHRRTTASIPENLKPNDIDLAKALELLSSSSIRRSG
        FYVQLGEDRKG++PKR S+SQIKDV SITLEDA+E L YP+TLG HPKDG  V+IK+ + GF V HRRT AS+P+NLKPND+DLAKALELLSS  +RR G
Subjt:  FYVQLGEDRKGFLPKRASLSQIKDVSSITLEDAVERLCYPVTLGKHPKDGEPVIIKMARVGFAVGHRRTTASIPENLKPNDIDLAKALELLSSSSIRRSG

Query:  RSKSNPKV
        R KS PKV
Subjt:  RSKSNPKV

SwissProt top hits

e value

%identity

Alignment

Q1RIM1 DNA topoisomerase 1

4.3e-47

36.86

Show/hide

Query:  MEELGIGRPSTYATTLKVLKDRKYVSVKSRVLHPEFRGRMVSAFLSHHFSEVTDYSFTADMENELDNVSAGLTEWKGLLRDYWTRFSSYFERVNSVHIHQ
        +EELGIGRPSTYAT L VL+DRKYV+++ +   PE  GR+V+ FL   F +  +Y FTA +ENELD ++AG  EWK  L ++W  F+   E VN  +I +
Subjt:  MEELGIGRPSTYATTLKVLKDRKYVSVKSRVLHPEFRGRMVSAFLSHHFSEVTDYSFTADMENELDNVSAGLTEWKGLLRDYWTRFSSYFERVNSVHIHQ

Query:  VEKMLEKKYGDFLFSFLPDNSRACPSCQEGTLIFKLSRFGPGYFIGCDQHPRCKHIAKTLHGEDEDNDNS-----FKEPKLLGLHPDLNEKILLKKGPFG
        +   +++     +F    D S+ CPSC+ G L  KL +FG   F+ C  +P C      + G D +  +        E K+LG   +   +I LKKGP+G
Subjt:  VEKMLEKKYGDFLFSFLPDNSRACPSCQEGTLIFKLSRFGPGYFIGCDQHPRCKHIAKTLHGEDEDNDNS-----FKEPKLLGLHPDLNEKILLKKGPFG

Query:  FYVQLGE--DRKGFLPKRASLSQIKDVSSITLEDAVERLCYPVTLGKHPKDGEPVIIKMARVGFAVGHRRTTASIPENLKPNDIDLAKALELL
         Y+Q GE  D K   PKR+ L    + + ITL+ A++ L  P+ +G H + GE V++   + G  + +     SIP+     ++ L  A++L+
Subjt:  FYVQLGE--DRKGFLPKRASLSQIKDVSSITLEDAVERLCYPVTLGKHPKDGEPVIIKMARVGFAVGHRRTTASIPENLKPNDIDLAKALELL

Q4UM42 DNA topoisomerase 1

1.1e-50

38.38

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Query:  MEELGIGRPSTYATTLKVLKDRKYVSVKSRVLHPEFRGRMVSAFLSHHFSEVTDYSFTADMENELDNVSAGLTEWKGLLRDYWTRFSSYFERVNSVHIHQ
        +EELGIGRPSTYA+ L VL+DRKYVS++ +   PE  GR+V+ FL   F +  +Y FTA +ENELD ++AG  EWK  L ++W+ F+   E VN   I +
Subjt:  MEELGIGRPSTYATTLKVLKDRKYVSVKSRVLHPEFRGRMVSAFLSHHFSEVTDYSFTADMENELDNVSAGLTEWKGLLRDYWTRFSSYFERVNSVHIHQ

Query:  VEKMLEKKYGDFLFSFLPDNSRACPSCQEGTLIFKLSRFGPGYFIGCDQHPRCKHIAKTLHGED-EDNDNSF----KEPKLLGLHPDLNEKILLKKGPFG
        +   ++K     LFS   + S+ACPSC+ G L  KL +FG   F+ C  +P C      + G D  +ND        E K+LG   D   +I LKKGP+G
Subjt:  VEKMLEKKYGDFLFSFLPDNSRACPSCQEGTLIFKLSRFGPGYFIGCDQHPRCKHIAKTLHGED-EDNDNSF----KEPKLLGLHPDLNEKILLKKGPFG

Query:  FYVQLGEDRKGFLPKRASLSQIKDVSSITLEDAVERLCYPVTLGKHPKDGEPVIIKMARVGFAVGHRRTTASIPENLKPNDIDLAKALELLSSSSIR
         YVQLGE      PKR+ +    + + ITLE A++ L  P+ +G H   GE ++I   + G  + +     SIP+     ++ L  A++L+  +  +
Subjt:  FYVQLGEDRKGFLPKRASLSQIKDVSSITLEDAVERLCYPVTLGKHPKDGEPVIIKMARVGFAVGHRRTTASIPENLKPNDIDLAKALELLSSSSIR

Q68X45 DNA topoisomerase 1

4.6e-49

36.18

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Query:  MEELGIGRPSTYATTLKVLKDRKYVSVKSRVLHPEFRGRMVSAFLSHHFSEVTDYSFTADMENELDNVSAGLTEWKGLLRDYWTRFSSYFERVNSVHIHQ
        +EELGIGRPSTYA+ L VL+DRKYV+++ +   PE  GR+V+ FL   F +  +Y FTA +ENELD ++AG  EWK  L ++W+ F++  E VN   I +
Subjt:  MEELGIGRPSTYATTLKVLKDRKYVSVKSRVLHPEFRGRMVSAFLSHHFSEVTDYSFTADMENELDNVSAGLTEWKGLLRDYWTRFSSYFERVNSVHIHQ

Query:  VEKMLEKKYGDFLFSFLPDNSRACPSCQEGTLIFKLSRFGPGYFIGCDQHPRCKHIAKTLHGEDEDNDNS-----FKEPKLLGLHPDLNEKILLKKGPFG
        +   L+K     LF    + S+ CPSC+ G L  KL +FG   F+ C  +P C      + G D + D         + K+LG   D   +I LK GP+G
Subjt:  VEKMLEKKYGDFLFSFLPDNSRACPSCQEGTLIFKLSRFGPGYFIGCDQHPRCKHIAKTLHGEDEDNDNS-----FKEPKLLGLHPDLNEKILLKKGPFG

Query:  FYVQLGEDRKGFLPKRASLSQIKDVSSITLEDAVERLCYPVTLGKHPKDGEPVIIKMARVGFAVGHRRTTASIPENLKPNDIDLAKALELLSSSSIRRSG
         Y+QLGE      PKR  +      S ITLE A++ L  P+ +G H   GE +II  ++ G  + +     S+P+     +++L  A++L+ ++  +   
Subjt:  FYVQLGEDRKGFLPKRASLSQIKDVSSITLEDAVERLCYPVTLGKHPKDGEPVIIKMARVGFAVGHRRTTASIPENLKPNDIDLAKALELLSSSSIRRSG

Query:  RSKS
        + +S
Subjt:  RSKS

Q92IH1 DNA topoisomerase 1

8.1e-46

35.23

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Query:  MEELGIGRPSTYATTLKVLKDRKYVSVKSRVLHPEFRGRMVSAFLSHHFSEVTDYSFTADMENELDNVSAGLTEWKGLLRDYWTRFSSYFERVNSVHIHQ
        +EELGIGRPSTYA+ L VL+DRKYV+++ +   PE  GR+V+ FL   F +  +Y FTA +ENELD ++AG  EWK  L ++W+ F+   E VN   I +
Subjt:  MEELGIGRPSTYATTLKVLKDRKYVSVKSRVLHPEFRGRMVSAFLSHHFSEVTDYSFTADMENELDNVSAGLTEWKGLLRDYWTRFSSYFERVNSVHIHQ

Query:  VEKMLEKKYGDFLFSFLPDNSRACPSCQEGTLIFKLSRFGPGYFIGCDQHPRCKHIAKTLHGEDEDNDNSFK------EPKLLGLHPDLNEKILLKKGPF
        +   ++K     LF    + S+ CPSC  G L  KL +FG   F+ C  +P C      + G D +N+N  +      E K+LG   D   +I LKKGP+
Subjt:  VEKMLEKKYGDFLFSFLPDNSRACPSCQEGTLIFKLSRFGPGYFIGCDQHPRCKHIAKTLHGEDEDNDNSFK------EPKLLGLHPDLNEKILLKKGPF

Query:  GFYVQLGEDRKGFLPKRASLSQIKDVSSITLEDAVERLCYPVTLGKHPKDGEPVIIKMARVGFAVGHRRTTASIPENLKPNDIDLAKALELLSSSSIR
        G Y+QLG+      PKR+ +    + + ITL+ A++ L  P+ +G H    E ++I   + G  + +     S+ +     ++ L  A++L+  +  +
Subjt:  GFYVQLGEDRKGFLPKRASLSQIKDVSSITLEDAVERLCYPVTLGKHPKDGEPVIIKMARVGFAVGHRRTTASIPENLKPNDIDLAKALELLSSSSIR

Q9ZDK2 DNA topoisomerase 1

3.5e-49

37.04

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Query:  MEELGIGRPSTYATTLKVLKDRKYVSVKSRVLHPEFRGRMVSAFLSHHFSEVTDYSFTADMENELDNVSAGLTEWKGLLRDYWTRFSSYFERVNSVHIHQ
        +EELGIGRPSTYA+ L VL+DRKYV+++ +   PE  GR+V+ FL   F +  +Y FTA +ENELD ++AG  EWK  L ++W  F+   E VN   I +
Subjt:  MEELGIGRPSTYATTLKVLKDRKYVSVKSRVLHPEFRGRMVSAFLSHHFSEVTDYSFTADMENELDNVSAGLTEWKGLLRDYWTRFSSYFERVNSVHIHQ

Query:  VEKMLEKKYGDFLFSFLPDNSRACPSCQEGTLIFKLSRFGPGYFIGCDQHPRCKHIAKTLHGEDEDNDNS-----FKEPKLLGLHPDLNEKILLKKGPFG
        +   L+K     LF      S+ CPSC+ G L  KL +FG   F+ C  +P C      + G D + D         + K+LG   D   +I LKKGP+G
Subjt:  VEKMLEKKYGDFLFSFLPDNSRACPSCQEGTLIFKLSRFGPGYFIGCDQHPRCKHIAKTLHGEDEDNDNS-----FKEPKLLGLHPDLNEKILLKKGPFG

Query:  FYVQLGEDRKGFLPKRASLSQIKDVSSITLEDAVERLCYPVTLGKHPKDGEPVIIKMARVGFAVGHRRTTASIPENLKPNDIDLAKALELLSSSSIR
         Y+QLGE      PKR  +      S ITLE A++ L  P+ +G H   GE +II  ++ G  + +     S+P+     ++ L  A++L+ ++  +
Subjt:  FYVQLGEDRKGFLPKRASLSQIKDVSSITLEDAVERLCYPVTLGKHPKDGEPVIIKMARVGFAVGHRRTTASIPENLKPNDIDLAKALELLSSSSIR

Arabidopsis top hits

e value

%identity

Alignment

AT4G31210.1 DNA topoisomerase, type IA, core

5.1e-120

65.78

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Query:  MEELGIGRPSTYATTLKVLKDRKYVSVKSRVLHPEFRGRMVSAFLSHHFSEVTDYSFTADMENELDNVSAGLTEWKGLLRDYWTRFSSYFERVNSVHIHQ
        +EELGIGRPSTYA+  +VL+ RKYV++K+RVL+PEFR RMVSAFL+H+F+E+TDYSFTADME ELDNVS G+TEWKGLLRDYWTRFS+Y +RV +V   Q
Subjt:  MEELGIGRPSTYATTLKVLKDRKYVSVKSRVLHPEFRGRMVSAFLSHHFSEVTDYSFTADMENELDNVSAGLTEWKGLLRDYWTRFSSYFERVNSVHIHQ

Query:  VEKMLEKKYGDFLFSFLPDNSRACPSCQEGTLIFKLSRFGPGYFIGCDQHPRCKHIAKTLHGEDEDND-----NSFKEPKLLGLHPDLNEKILLKKGPFG
        VEKMLEKKY D LFS LP  SR CPSC EGTL FK S+FG GYFIGCDQHP CK IAKTL+GEDED D     N  +EPKLLGLHP+ +EK++LK GP+G
Subjt:  VEKMLEKKYGDFLFSFLPDNSRACPSCQEGTLIFKLSRFGPGYFIGCDQHPRCKHIAKTLHGEDEDND-----NSFKEPKLLGLHPDLNEKILLKKGPFG

Query:  FYVQLGEDRKGFLPKRASLSQIKDVSSITLEDAVERLCYPVTLGKHPKDGEPVIIKMARVGFAVGHRRTTASIPENLKPNDIDLAKALELLSSSSIRRSG
         YVQLGED+KG  PKRA+ + IKDV+SITLE A+E L YP+TLG HP+DG+PV++K+++ GF + HRR  A++P+N +P ++ L +A++LLS  ++R+SG
Subjt:  FYVQLGEDRKGFLPKRASLSQIKDVSSITLEDAVERLCYPVTLGKHPKDGEPVIIKMARVGFAVGHRRTTASIPENLKPNDIDLAKALELLSSSSIRRSG

Query:  R
        R
Subjt:  R

Sequences

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CDS sequence

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ATGGAGGAGCTAGGGATTGGAAGACCTTCCACATATGCAACCACACTAAAAGTTTTAAAGGACAGGAAATACGTGTCAGTGAAAAGTCGTGTTCTACATCCAGAGTTTCG
TGGGCGCATGGTATCGGCATTTCTTTCTCATCATTTCTCTGAGGTCACCGATTATAGTTTTACTGCAGACATGGAAAATGAGCTTGATAATGTCTCGGCTGGTTTAACTG
AATGGAAAGGCCTCCTAAGAGATTATTGGACCCGGTTCAGCTCATATTTTGAACGTGTTAATAGTGTTCATATTCATCAGGTGGAAAAGATGTTGGAGAAGAAATATGGG
GACTTCTTATTTTCTTTTCTTCCTGATAATTCCAGAGCATGTCCAAGTTGTCAGGAGGGCACTCTGATCTTCAAACTTAGTCGGTTTGGTCCTGGCTATTTCATAGGTTG
TGATCAACACCCAAGATGCAAGCATATTGCAAAAACGTTACATGGTGAGGATGAAGACAATGACAACAGTTTTAAAGAGCCAAAATTGCTTGGTCTTCATCCAGATTTGA
ACGAAAAGATTCTTTTGAAGAAAGGTCCATTTGGGTTTTATGTACAACTTGGCGAGGACAGGAAAGGGTTCTTGCCCAAAAGAGCCTCTCTTTCCCAGATAAAGGACGTG
AGTTCTATTACTCTCGAGGATGCTGTTGAACGTTTATGCTACCCGGTTACTTTGGGAAAACATCCAAAGGATGGCGAACCAGTGATAATAAAGATGGCAAGAGTTGGATT
CGCAGTTGGACATCGACGCACGACAGCTTCCATTCCTGAGAATCTGAAGCCAAACGACATCGATTTAGCGAAAGCGTTGGAGCTTCTGTCTAGTAGCAGTATTAGGAGGT
CTGGGCGATCTAAAAGCAACCCCAAGGTTGCAAGCTGTTGA

mRNA sequence

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Protein sequence

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MEELGIGRPSTYATTLKVLKDRKYVSVKSRVLHPEFRGRMVSAFLSHHFSEVTDYSFTADMENELDNVSAGLTEWKGLLRDYWTRFSSYFERVNSVHIHQVEKMLEKKYG
DFLFSFLPDNSRACPSCQEGTLIFKLSRFGPGYFIGCDQHPRCKHIAKTLHGEDEDNDNSFKEPKLLGLHPDLNEKILLKKGPFGFYVQLGEDRKGFLPKRASLSQIKDV
SSITLEDAVERLCYPVTLGKHPKDGEPVIIKMARVGFAVGHRRTTASIPENLKPNDIDLAKALELLSSSSIRRSGRSKSNPKVASC

IVF0024332 (gene) of Melon (IVF77) v1 genome