CuGenDBv2

Gene ID	Lag0001885
Organism	Luffa acutangula AG-4 (Sponge gourd (AG-4) v1)
Description	Non-specific serine/threonine protein kinase
Genome location	chr4:36519744..36521870
RNA-Seq Expression	Lag0001885
Synteny	Lag0001885
Gene Ontology terms	GO:0006521 - regulation of cellular amino acid metabolic process (biological process) GO:0009635 - response to herbicide (biological process) GO:0010998 - regulation of translational initiation by eIF2 alpha phosphorylation (biological process) GO:0018105 - peptidyl-serine phosphorylation (biological process) GO:0005886 - plasma membrane (cellular component) GO:0000049 - tRNA binding (molecular function) GO:0004694 - eukaryotic translation initiation factor 2alpha kinase activity (molecular function) GO:0004712 - protein serine/threonine/tyrosine kinase activity (molecular function) GO:0005524 - ATP binding (molecular function) GO:0106310 - protein serine kinase activity (molecular function)
InterPro domains	NA

Homology

Show/hide homology

GenBank top hits

e value

%identity

Alignment

KAG6592986.1 eIF-2-alpha kinase GCN2, partial [Cucurbita argyrosperma subsp. sororia]

1.1e-46

79.85

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Query:  VGCTHTDNNSQSLEDKVTSNEKKGPYVHGYIDLFSGSGELWSWSFDMDEKLNSQTQTPAADSLKLGAVRENKLDKVQNLLVRQDSKRGELPSPSSNLGTL
        VGC++TDNNSQ L DKVTSNE KGPYVHGYIDLFSGSGELWSWSFDMDEK  SQ Q P ADSLKLG V+E  LDKVQNLL +Q+SKRGEL SPS NLGTL
Subjt:  VGCTHTDNNSQSLEDKVTSNEKKGPYVHGYIDLFSGSGELWSWSFDMDEKLNSQTQTPAADSLKLGAVRENKLDKVQNLLVRQDSKRGELPSPSSNLGTL

Query:  VEESEDDSQSITSSHSRRSLILQTAGDDIEGEKQ
         EESED+S SITSSHSRRSLI+Q AGD  E EKQ
Subjt:  VEESEDDSQSITSSHSRRSLILQTAGDDIEGEKQ

XP_022150409.1 eIF-2-alpha kinase GCN2 isoform X1 [Momordica charantia]

2.8e-47

75.18

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Query:  LSEVGCTHTDNNSQSLEDKVTSNEKKGPYVHGYIDLFSGSGELWSWSFDMDEKLNSQTQTPAADSLKLGAVRENKLDKVQNLLVRQDSKRGELPSPSSNL
        L  VGC+H+D NSQ L D VTS+ KKGPYVHGYIDLFSGSGELWSWSFDM+E LNSQ Q    DSLKLG V+E KL+K QNL   + SKRGELPSPSSNL
Subjt:  LSEVGCTHTDNNSQSLEDKVTSNEKKGPYVHGYIDLFSGSGELWSWSFDMDEKLNSQTQTPAADSLKLGAVRENKLDKVQNLLVRQDSKRGELPSPSSNL

Query:  GTLVEESEDDSQSITSSHSRRSLILQTAGDDIEGEKQ
        GTL EESEDDSQSITSSHSRRSL++Q AGD I+ EKQ
Subjt:  GTLVEESEDDSQSITSSHSRRSLILQTAGDDIEGEKQ

XP_022150410.1 eIF-2-alpha kinase GCN2 isoform X2 [Momordica charantia]

2.8e-47

75.18

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Query:  LSEVGCTHTDNNSQSLEDKVTSNEKKGPYVHGYIDLFSGSGELWSWSFDMDEKLNSQTQTPAADSLKLGAVRENKLDKVQNLLVRQDSKRGELPSPSSNL
        L  VGC+H+D NSQ L D VTS+ KKGPYVHGYIDLFSGSGELWSWSFDM+E LNSQ Q    DSLKLG V+E KL+K QNL   + SKRGELPSPSSNL
Subjt:  LSEVGCTHTDNNSQSLEDKVTSNEKKGPYVHGYIDLFSGSGELWSWSFDMDEKLNSQTQTPAADSLKLGAVRENKLDKVQNLLVRQDSKRGELPSPSSNL

Query:  GTLVEESEDDSQSITSSHSRRSLILQTAGDDIEGEKQ
        GTL EESEDDSQSITSSHSRRSL++Q AGD I+ EKQ
Subjt:  GTLVEESEDDSQSITSSHSRRSLILQTAGDDIEGEKQ

XP_023004333.1 eIF-2-alpha kinase GCN2 isoform X1 [Cucurbita maxima]

1.1e-46

79.85

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Query:  VGCTHTDNNSQSLEDKVTSNEKKGPYVHGYIDLFSGSGELWSWSFDMDEKLNSQTQTPAADSLKLGAVRENKLDKVQNLLVRQDSKRGELPSPSSNLGTL
        VGC++TDNNSQ L DKVTSNE KGPYVHGYIDLFSGSGELWSWSFDMDEK  SQ Q P ADSLKLG V+E  LDKVQNLL +Q+SKRGEL SPS NLGTL
Subjt:  VGCTHTDNNSQSLEDKVTSNEKKGPYVHGYIDLFSGSGELWSWSFDMDEKLNSQTQTPAADSLKLGAVRENKLDKVQNLLVRQDSKRGELPSPSSNLGTL

Query:  VEESEDDSQSITSSHSRRSLILQTAGDDIEGEKQ
         EESED+S SITSSHSRRSLI+Q AGD  E EKQ
Subjt:  VEESEDDSQSITSSHSRRSLILQTAGDDIEGEKQ

XP_023004335.1 eIF-2-alpha kinase GCN2 isoform X2 [Cucurbita maxima]

1.1e-46

79.85

Show/hide

Query:  VGCTHTDNNSQSLEDKVTSNEKKGPYVHGYIDLFSGSGELWSWSFDMDEKLNSQTQTPAADSLKLGAVRENKLDKVQNLLVRQDSKRGELPSPSSNLGTL
        VGC++TDNNSQ L DKVTSNE KGPYVHGYIDLFSGSGELWSWSFDMDEK  SQ Q P ADSLKLG V+E  LDKVQNLL +Q+SKRGEL SPS NLGTL
Subjt:  VGCTHTDNNSQSLEDKVTSNEKKGPYVHGYIDLFSGSGELWSWSFDMDEKLNSQTQTPAADSLKLGAVRENKLDKVQNLLVRQDSKRGELPSPSSNLGTL

Query:  VEESEDDSQSITSSHSRRSLILQTAGDDIEGEKQ
         EESED+S SITSSHSRRSLI+Q AGD  E EKQ
Subjt:  VEESEDDSQSITSSHSRRSLILQTAGDDIEGEKQ

TrEMBL top hits

e value

%identity

Alignment

A0A1S3BE48 eIF-2-alpha kinase GCN2 isoform X4

5.7e-46

76.47

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Query:  VGCTHTDNNSQSLEDKVTSNEKKGPYVHGYIDLFSGSGELWSWSFDMDEKLNSQTQTPAADSLKLGAVRENKLDKVQNLLVRQDSKRGELPSPSSNLGTL
        VGC+HT + SQ L DK+TSNEKKGPYV+GYIDLFSGSGELWSWSFDMDEKLNSQ Q   A+SLKLG V+E KLDKVQNLL RQ+SKRGEL SPSSNLGTL
Subjt:  VGCTHTDNNSQSLEDKVTSNEKKGPYVHGYIDLFSGSGELWSWSFDMDEKLNSQTQTPAADSLKLGAVRENKLDKVQNLLVRQDSKRGELPSPSSNLGTL

Query:  VEESEDDSQSITSSHSRRSLILQTAGDDIEGEKQGE
         EE+E DSQSI SS+S RSLI+Q   D  EGEKQ E
Subjt:  VEESEDDSQSITSSHSRRSLILQTAGDDIEGEKQGE

A0A6J1D8E1 Non-specific serine/threonine protein kinase

1.4e-47

75.18

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Query:  LSEVGCTHTDNNSQSLEDKVTSNEKKGPYVHGYIDLFSGSGELWSWSFDMDEKLNSQTQTPAADSLKLGAVRENKLDKVQNLLVRQDSKRGELPSPSSNL
        L  VGC+H+D NSQ L D VTS+ KKGPYVHGYIDLFSGSGELWSWSFDM+E LNSQ Q    DSLKLG V+E KL+K QNL   + SKRGELPSPSSNL
Subjt:  LSEVGCTHTDNNSQSLEDKVTSNEKKGPYVHGYIDLFSGSGELWSWSFDMDEKLNSQTQTPAADSLKLGAVRENKLDKVQNLLVRQDSKRGELPSPSSNL

Query:  GTLVEESEDDSQSITSSHSRRSLILQTAGDDIEGEKQ
        GTL EESEDDSQSITSSHSRRSL++Q AGD I+ EKQ
Subjt:  GTLVEESEDDSQSITSSHSRRSLILQTAGDDIEGEKQ

A0A6J1D9Z7 Non-specific serine/threonine protein kinase

1.4e-47

75.18

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Query:  LSEVGCTHTDNNSQSLEDKVTSNEKKGPYVHGYIDLFSGSGELWSWSFDMDEKLNSQTQTPAADSLKLGAVRENKLDKVQNLLVRQDSKRGELPSPSSNL
        L  VGC+H+D NSQ L D VTS+ KKGPYVHGYIDLFSGSGELWSWSFDM+E LNSQ Q    DSLKLG V+E KL+K QNL   + SKRGELPSPSSNL
Subjt:  LSEVGCTHTDNNSQSLEDKVTSNEKKGPYVHGYIDLFSGSGELWSWSFDMDEKLNSQTQTPAADSLKLGAVRENKLDKVQNLLVRQDSKRGELPSPSSNL

Query:  GTLVEESEDDSQSITSSHSRRSLILQTAGDDIEGEKQ
        GTL EESEDDSQSITSSHSRRSL++Q AGD I+ EKQ
Subjt:  GTLVEESEDDSQSITSSHSRRSLILQTAGDDIEGEKQ

A0A6J1KUA6 Non-specific serine/threonine protein kinase

5.2e-47

79.85

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Query:  VGCTHTDNNSQSLEDKVTSNEKKGPYVHGYIDLFSGSGELWSWSFDMDEKLNSQTQTPAADSLKLGAVRENKLDKVQNLLVRQDSKRGELPSPSSNLGTL
        VGC++TDNNSQ L DKVTSNE KGPYVHGYIDLFSGSGELWSWSFDMDEK  SQ Q P ADSLKLG V+E  LDKVQNLL +Q+SKRGEL SPS NLGTL
Subjt:  VGCTHTDNNSQSLEDKVTSNEKKGPYVHGYIDLFSGSGELWSWSFDMDEKLNSQTQTPAADSLKLGAVRENKLDKVQNLLVRQDSKRGELPSPSSNLGTL

Query:  VEESEDDSQSITSSHSRRSLILQTAGDDIEGEKQ
         EESED+S SITSSHSRRSLI+Q AGD  E EKQ
Subjt:  VEESEDDSQSITSSHSRRSLILQTAGDDIEGEKQ

A0A6J1KZ64 Non-specific serine/threonine protein kinase

5.2e-47

79.85

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Query:  VGCTHTDNNSQSLEDKVTSNEKKGPYVHGYIDLFSGSGELWSWSFDMDEKLNSQTQTPAADSLKLGAVRENKLDKVQNLLVRQDSKRGELPSPSSNLGTL
        VGC++TDNNSQ L DKVTSNE KGPYVHGYIDLFSGSGELWSWSFDMDEK  SQ Q P ADSLKLG V+E  LDKVQNLL +Q+SKRGEL SPS NLGTL
Subjt:  VGCTHTDNNSQSLEDKVTSNEKKGPYVHGYIDLFSGSGELWSWSFDMDEKLNSQTQTPAADSLKLGAVRENKLDKVQNLLVRQDSKRGELPSPSSNLGTL

Query:  VEESEDDSQSITSSHSRRSLILQTAGDDIEGEKQ
         EESED+S SITSSHSRRSLI+Q AGD  E EKQ
Subjt:  VEESEDDSQSITSSHSRRSLILQTAGDDIEGEKQ

SwissProt top hits

e value

%identity

Alignment

Q9LX30 eIF-2-alpha kinase GCN2

1.2e-05

34.78

Show/hide

Query:  VGCTHTDNNSQSLEDKVTSNEKK----GPYVHGYIDLFSGSGELWSWSFDMDEK--LNSQTQTPAADSLKLGAVRENKLDKVQNLLVRQDSKRGE--LPS
        V C     ++Q +E  + SN  K    GP+V+G+IDLFSG  +  +WS   DE   + S  Q+   D+ +   +   K DK  NL   +D  + E  LP+
Subjt:  VGCTHTDNNSQSLEDKVTSNEKK----GPYVHGYIDLFSGSGELWSWSFDMDEK--LNSQTQTPAADSLKLGAVRENKLDKVQNLLVRQDSKRGE--LPS

Query:  PSSNLGTLVEESEDDSQSITSSHSRRSLILQTAGDDIE
        P + L T+ EE+ DD+ SI+S  S +S       DD+E
Subjt:  PSSNLGTLVEESEDDSQSITSSHSRRSLILQTAGDDIE

Arabidopsis top hits

e value

%identity

Alignment

AT3G59410.1 protein kinase family protein

8.8e-07

34.78

Show/hide

Query:  VGCTHTDNNSQSLEDKVTSNEKK----GPYVHGYIDLFSGSGELWSWSFDMDEK--LNSQTQTPAADSLKLGAVRENKLDKVQNLLVRQDSKRGE--LPS
        V C     ++Q +E  + SN  K    GP+V+G+IDLFSG  +  +WS   DE   + S  Q+   D+ +   +   K DK  NL   +D  + E  LP+
Subjt:  VGCTHTDNNSQSLEDKVTSNEKK----GPYVHGYIDLFSGSGELWSWSFDMDEK--LNSQTQTPAADSLKLGAVRENKLDKVQNLLVRQDSKRGE--LPS

Query:  PSSNLGTLVEESEDDSQSITSSHSRRSLILQTAGDDIE
        P + L T+ EE+ DD+ SI+S  S +S       DD+E
Subjt:  PSSNLGTLVEESEDDSQSITSSHSRRSLILQTAGDDIE

AT3G59410.2 protein kinase family protein

8.8e-07

34.78

Show/hide

Query:  VGCTHTDNNSQSLEDKVTSNEKK----GPYVHGYIDLFSGSGELWSWSFDMDEK--LNSQTQTPAADSLKLGAVRENKLDKVQNLLVRQDSKRGE--LPS
        V C     ++Q +E  + SN  K    GP+V+G+IDLFSG  +  +WS   DE   + S  Q+   D+ +   +   K DK  NL   +D  + E  LP+
Subjt:  VGCTHTDNNSQSLEDKVTSNEKK----GPYVHGYIDLFSGSGELWSWSFDMDEK--LNSQTQTPAADSLKLGAVRENKLDKVQNLLVRQDSKRGE--LPS

Query:  PSSNLGTLVEESEDDSQSITSSHSRRSLILQTAGDDIE
        P + L T+ EE+ DD+ SI+S  S +S       DD+E
Subjt:  PSSNLGTLVEESEDDSQSITSSHSRRSLILQTAGDDIE

Sequences

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CDS sequence

Show/hide CDS sequence

ATGCTCAGTGAAGTTGGCTGTACTCATACAGATAACAATTCTCAATCGCTTGAAGACAAAGTAACTTCAAATGAGAAGAAAGGACCTTATGTTCATGGCTATATAGACCT
CTTCAGTGGTTCTGGGGAGTTGTGGAGCTGGAGCTTTGACATGGATGAGAAGCTCAACTCCCAAACACAAACCCCTGCAGCAGATAGCTTGAAACTGGGAGCAGTCCGAG
AAAACAAGCTTGATAAAGTTCAAAACCTATTGGTTAGGCAAGATTCAAAGCGAGGTGAATTGCCATCTCCTTCCTCTAACCTAGGTACCCTCGTGGAAGAAAGTGAAGAT
GACAGTCAGAGCATAACTTCTTCTCACTCAAGAAGATCCCTAATCCTACAGACGGCTGGAGATGATATTGAAGGTGAGAAGCAGGGAGAAAATGGGCCGATTGAGATGAA
GGTTGGGCTAGAGTCTAAACAGAATATGGGCATTCCGTTTGATAATGTGGGGGACAAAGATCACGTTTTGGAGTGGGCTGTTGAGTTTAACCCTTCGGAGGATCTTCTTA
ACGAGGAGGATGATGGCTCCAACCCTTTAGTGGTGAGTTACTCTGAGGATGAGTCGTTTTTATCAACTCTTGCAACTAAAGAAATGGAAACCATGAATTTGAATTCTATG
TTCTCGAAGGAGAAAGCATCGCTACAACAAAACCACTCTCCACAGAAGGATGACCAACAGATAATTCCTTCCGAATCTGAAATAGACATGAAGAATGATTCTTTAGCTGT
GCTGGTAGGGGTGCTTCAGGATCTCTCGGTTATGGGAGATCCGCCTTAG

mRNA sequence

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Protein sequence

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MLSEVGCTHTDNNSQSLEDKVTSNEKKGPYVHGYIDLFSGSGELWSWSFDMDEKLNSQTQTPAADSLKLGAVRENKLDKVQNLLVRQDSKRGELPSPSSNLGTLVEESED
DSQSITSSHSRRSLILQTAGDDIEGEKQGENGPIEMKVGLESKQNMGIPFDNVGDKDHVLEWAVEFNPSEDLLNEEDDGSNPLVVSYSEDESFLSTLATKEMETMNLNSM
FSKEKASLQQNHSPQKDDQQIIPSESEIDMKNDSLAVLVGVLQDLSVMGDPP

Lag0001885 (gene) of Sponge gourd (AG-4) v1 genome