CuGenDBv2

Gene ID	Lag0010517
Organism	Luffa acutangula AG-4 (Sponge gourd (AG-4) v1)
Description	tyrosyl-DNA phosphodiesterase 1 isoform X2
Genome location	chr1:375770..381511
RNA-Seq Expression	Lag0010517
Synteny	Lag0010517
Gene Ontology terms	GO:0006281 - DNA repair (biological process) GO:0005634 - nucleus (cellular component) GO:0016020 - membrane (cellular component) GO:0008081 - phosphoric diester hydrolase activity (molecular function)
InterPro domains	IPR010347 - Tyrosyl-DNA phosphodiesterase I

Homology

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GenBank top hits

e value

%identity

Alignment

KAG6603760.1 Tyrosyl-DNA phosphodiesterase 1, partial [Cucurbita argyrosperma subsp. sororia]

1.7e-20

26.53

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Query:  SDNRTTSLFSNGSHPSPNFSSHNRSAYLLLLIFCLFTFSNYFSIFLCGKKVGHLLQCGSEAIHNFHFPDDRWPMTFKLLSVKGLPPWANTSCVRITDV-I
        S ++T SL  NGS P P+FS++    Y     F LF FSNYFS+F  GKKVG+L+              +      K+   +G P     S V ++D  I
Subjt:  SDNRTTSLFSNGSHPSPNFSSHNRSAYLLLLIFCLFTFSNYFSIFLCGKKVGHLLQCGSEAIHNFHFPDDRWPMTFKLLSVKGLPPWANTSCVRITDV-I

Query:  QRKKPANWVYQNSSARGCAFEDELVDYLSALKCPRQQGCVKCGYYVTKFMR--EILHNPKTLIAALFNTKNPFTQEQLDEVFRMWDLNYCNKYVAGGVDK
         RK        + SA+       LV+  + +      G  K G   +  +R  E++          +    P T+   +++ +       +  ++    K
Subjt:  QRKKPANWVYQNSSARGCAFEDELVDYLSALKCPRQQGCVKCGYYVTKFMR--EILHNPKTLIAALFNTKNPFTQEQLDEVFRMWDLNYCNKYVAGGVDK

Query:  DVGFAGFSDNRTTSLFSNGSHPSPNFSSHNRSAYLLLLIFCLFTFSNYFSIFLCGKKVGHLLQCGSEAIHNFHFPDDRWPMTFKLLSVKGLPPWANTSCV
         V   G  +N+ T +  +    S                                           EAI NFH PDD+ PMTF+LLSVKGLPPWANTSCV
Subjt:  DVGFAGFSDNRTTSLFSNGSHPSPNFSSHNRSAYLLLLIFCLFTFSNYFSIFLCGKKVGHLLQCGSEAIHNFHFPDDRWPMTFKLLSVKGLPPWANTSCV

Query:  RITDVIQ----------------------------------------------RKKPANWVY--------------------------------------
        RI+DVIQ                                              RKKPANW+                                       
Subjt:  RITDVIQ----------------------------------------------RKKPANWVY--------------------------------------

Query:  -----------------QNSSARGCAFEDELVDYLSALKCP
                         QNSS RGCAFED+LVDYLSALK P
Subjt:  -----------------QNSSARGCAFEDELVDYLSALKCP

KGN49134.1 hypothetical protein Csa_003275 [Cucumis sativus]

1.9e-16

36.57

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Query:  EAIHNFHFPDDRWPMTFKLLSVKGLPPWANTSCVRITDVIQ----------------------------------------------RKKPANWVY----
        EAI NFH PDDR PMTF+LLSVKGLPPWANTSCVRITD+IQ                                              RKKPANW+     
Subjt:  EAIHNFHFPDDRWPMTFKLLSVKGLPPWANTSCVRITDVIQ----------------------------------------------RKKPANWVY----

Query:  ---------------------------------------------------QNSSARGCAFEDELVDYLSALKCP
                                                           QNSS+RGCAFED+LVDYLSALK P
Subjt:  ---------------------------------------------------QNSSARGCAFEDELVDYLSALKCP

XP_008439959.1 PREDICTED: tyrosyl-DNA phosphodiesterase 1 isoform X2 [Cucumis melo]

7.2e-16

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Query:  EAIHNFHFPDDRWPMTFKLLSVKGLPPWANTSCVRITDVIQ----------------------------------------------RKKPANWVY----
        EAI NFH PDDR PMTF+LLSVKGLPPWANTSCVRITD+IQ                                              RKKPANW+     
Subjt:  EAIHNFHFPDDRWPMTFKLLSVKGLPPWANTSCVRITDVIQ----------------------------------------------RKKPANWVY----

Query:  ---------------------------------------------------QNSSARGCAFEDELVDYLSALKCP
                                                           QNSS RGCAFED+LV+YLSALK P
Subjt:  ---------------------------------------------------QNSSARGCAFEDELVDYLSALKCP

XP_011658164.2 tyrosyl-DNA phosphodiesterase 1 isoform X1 [Cucumis sativus]

1.9e-16

36.57

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Query:  EAIHNFHFPDDRWPMTFKLLSVKGLPPWANTSCVRITDVIQ----------------------------------------------RKKPANWVY----
        EAI NFH PDDR PMTF+LLSVKGLPPWANTSCVRITD+IQ                                              RKKPANW+     
Subjt:  EAIHNFHFPDDRWPMTFKLLSVKGLPPWANTSCVRITDVIQ----------------------------------------------RKKPANWVY----

Query:  ---------------------------------------------------QNSSARGCAFEDELVDYLSALKCP
                                                           QNSS+RGCAFED+LVDYLSALK P
Subjt:  ---------------------------------------------------QNSSARGCAFEDELVDYLSALKCP

XP_031743893.1 tyrosyl-DNA phosphodiesterase 1 isoform X2 [Cucumis sativus]

1.9e-16

36.57

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Query:  EAIHNFHFPDDRWPMTFKLLSVKGLPPWANTSCVRITDVIQ----------------------------------------------RKKPANWVY----
        EAI NFH PDDR PMTF+LLSVKGLPPWANTSCVRITD+IQ                                              RKKPANW+     
Subjt:  EAIHNFHFPDDRWPMTFKLLSVKGLPPWANTSCVRITDVIQ----------------------------------------------RKKPANWVY----

Query:  ---------------------------------------------------QNSSARGCAFEDELVDYLSALKCP
                                                           QNSS+RGCAFED+LVDYLSALK P
Subjt:  ---------------------------------------------------QNSSARGCAFEDELVDYLSALKCP

TrEMBL top hits

e value

%identity

Alignment

A0A0A0KJY5 FHA domain-containing protein

9.2e-17

36.57

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Query:  EAIHNFHFPDDRWPMTFKLLSVKGLPPWANTSCVRITDVIQ----------------------------------------------RKKPANWVY----
        EAI NFH PDDR PMTF+LLSVKGLPPWANTSCVRITD+IQ                                              RKKPANW+     
Subjt:  EAIHNFHFPDDRWPMTFKLLSVKGLPPWANTSCVRITDVIQ----------------------------------------------RKKPANWVY----

Query:  ---------------------------------------------------QNSSARGCAFEDELVDYLSALKCP
                                                           QNSS+RGCAFED+LVDYLSALK P
Subjt:  ---------------------------------------------------QNSSARGCAFEDELVDYLSALKCP

A0A1S3AZK7 tyrosyl-DNA phosphodiesterase 1 isoform X1

3.5e-16

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Query:  EAIHNFHFPDDRWPMTFKLLSVKGLPPWANTSCVRITDVIQ----------------------------------------------RKKPANWVY----
        EAI NFH PDDR PMTF+LLSVKGLPPWANTSCVRITD+IQ                                              RKKPANW+     
Subjt:  EAIHNFHFPDDRWPMTFKLLSVKGLPPWANTSCVRITDVIQ----------------------------------------------RKKPANWVY----

Query:  ---------------------------------------------------QNSSARGCAFEDELVDYLSALKCP
                                                           QNSS RGCAFED+LV+YLSALK P
Subjt:  ---------------------------------------------------QNSSARGCAFEDELVDYLSALKCP

A0A1S3B014 tyrosyl-DNA phosphodiesterase 1 isoform X2

3.5e-16

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Query:  EAIHNFHFPDDRWPMTFKLLSVKGLPPWANTSCVRITDVIQ----------------------------------------------RKKPANWVY----
        EAI NFH PDDR PMTF+LLSVKGLPPWANTSCVRITD+IQ                                              RKKPANW+     
Subjt:  EAIHNFHFPDDRWPMTFKLLSVKGLPPWANTSCVRITDVIQ----------------------------------------------RKKPANWVY----

Query:  ---------------------------------------------------QNSSARGCAFEDELVDYLSALKCP
                                                           QNSS RGCAFED+LV+YLSALK P
Subjt:  ---------------------------------------------------QNSSARGCAFEDELVDYLSALKCP

A0A6J1GF28 tyrosyl-DNA phosphodiesterase 1 isoform X1

7.8e-16

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Query:  EAIHNFHFPDDRWPMTFKLLSVKGLPPWANTSCVRITDVIQ----------------------------------------------RKKPANWVY----
        EAI NFH PDD+ PMTF+LLSVKGLPPWANTSCVRI+DVIQ                                              RKKPANW+     
Subjt:  EAIHNFHFPDDRWPMTFKLLSVKGLPPWANTSCVRITDVIQ----------------------------------------------RKKPANWVY----

Query:  ---------------------------------------------------QNSSARGCAFEDELVDYLSALKCP
                                                           QNSS RGCAFED+LVDYLSALK P
Subjt:  ---------------------------------------------------QNSSARGCAFEDELVDYLSALKCP

A0A6J1INX7 tyrosyl-DNA phosphodiesterase 1 isoform X1

7.8e-16

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Query:  EAIHNFHFPDDRWPMTFKLLSVKGLPPWANTSCVRITDVIQ----------------------------------------------RKKPANWVY----
        EAI NFH PDD+ PMTF+LLSVKGLPPWANTSCVRI+DVIQ                                              RKKPANW+     
Subjt:  EAIHNFHFPDDRWPMTFKLLSVKGLPPWANTSCVRITDVIQ----------------------------------------------RKKPANWVY----

Query:  ---------------------------------------------------QNSSARGCAFEDELVDYLSALKCP
                                                           QNSS RGCAFED+LVDYLSALK P
Subjt:  ---------------------------------------------------QNSSARGCAFEDELVDYLSALKCP

SwissProt top hits

e value

%identity

Alignment

Q8H1D9 Tyrosyl-DNA phosphodiesterase 1

1.1e-06

60.98

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Query:  EAIHNFHFPDDRWPMTFKLLSVKGLPPWANTSCVRITDVIQ
        EAI  F  P+++ P TF+LLSV  LP WANTSCV I DVI+
Subjt:  EAIHNFHFPDDRWPMTFKLLSVKGLPPWANTSCVRITDVIQ

Arabidopsis top hits

e value

%identity

Alignment

AT5G15170.1 tyrosyl-DNA phosphodiesterase-related

7.7e-08

60.98

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Query:  EAIHNFHFPDDRWPMTFKLLSVKGLPPWANTSCVRITDVIQ
        EAI  F  P+++ P TF+LLSV  LP WANTSCV I DVI+
Subjt:  EAIHNFHFPDDRWPMTFKLLSVKGLPPWANTSCVRITDVIQ

Sequences

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CDS sequence

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ATGATAGTGTGGATCGGAGCCATTCACAATTTTCATTTTCCGGATGACAGATGGCCAATGACTTTCAAACTTTTGAGCGTTAAAGGCCTGCCACCATGGGCTAATACATC
ATGTGTGAGGATTACTGATGTTATACAGAGGAAGAAGCCTGCAAATTGGGTTTATCAAAATTCATCTGCAAGAGGATGTGCATTTGAAGATGAGCTGGTTGATTATCTTA
GCGCTTTGAAGTGTCCTCGCCAACAAGGTTGCGTTAAATGTGGGTACTACGTGACGAAGTTTATGAGAGAAATTCTACATAATCCAAAGACTCTCATCGCTGCCCTCTTT
AATACTAAGAATCCGTTCACACAAGAACAGTTGGACGAGGTATTCAGGATGTGGGATTTGAATTACTGCAATAAATATGTTGCAGGTGGGGTCGACAAAGATGTCGGGTT
TGCAGGATTTTCTGACAACAGAACGACCTCTCTGTTCAGCAATGGCTCGCATCCAAGTCCCAACTTTTCATCTCACAATCGATCGGCTTATTTGCTCTTACTCATCTTTT
GTTTATTTACTTTCTCTAATTACTTTTCTATATTCTTATGCGGGAAGAAGGTTGGGCATTTGTTACAGTGTGGATCGGAGGCCATTCACAATTTTCATTTTCCGGATGAC
AGATGGCCAATGACTTTCAAACTTTTGAGCGTTAAAGGCCTGCCACCATGGGCTAATACATCATGTGTGAGGATTACTGATGTTATACAGAGGAAGAAGCCTGCAAATTG
GGTTTATCAAAATTCATCTGCAAGAGGATGTGCATTTGAAGATGAGCTGGTTGATTATCTTAGCGCTTTGAAGTGTCCTCGCCAACAAGGTTGCGTTAAATGTGGGTACT
ACGTGACGAAGTTTATGAGAGAAATTCTACATAATCCAAAGACTCTCATCGCTGCCCTCTTTAATACTAAGAATCCGTTCACACAAGAACAGTTGGACGAGGTATTCAGG
ATGTGGGATTTGAATTACTGCAATAAATATGTTGCAGGTGGGGTCGACAAAGATGTCGGGTTTGCAGGATTTTCTGACAACAGAACGACCTCTCTGTTCAGCAATGGCTC
GCATCCAAGTCCCAACTTTTCATCTCACAATCGATCGGCTTATTTGCTCTTACTCATCTTTTGTTTATTTACTTTCTCTAATTACTTTTCTATATTCTTATGCGGGAAGA
AGGTTGGGCATTTGTTACAGTGTGGATCGGAGGCCATTCACAATTTTCATTTTCCGGATGACAGATGGCCAATGACTTTCAAACTTTTGAGCGTTAAAGGCCTGCCACCA
TGGGCTAATACATCATGTGTGAGGATTACTGATGTTATACAGAGGAAGAAGCCTGCAAATTGGGTTTATCAAAATTCATCTGCAAGAGGATGTGCATTTGAAGATGAGCT
GGTTGATTATCTTAGCGCTTTGAAGTGTCCTCGCCAACAAGGTTGCGTTAAATGTGGGTACTACGTGACGAAGTTTATGAGAGAAATTCTACATAATCCAAAGACTCTCA
TCGCTGCCCTCTTTAATACTAAGAATCCGTTCACACAAGAACAGTTGGACGAGGTATTCAGGATGTGGGATTTGAATTACTGCAATAAATATGTTGCAGGTGGGGTCGAC
AAAGATGTCGGGTTTGAAACTGTCATCGTTGTAATCCGTGATCGTATAGGAAAATCACAGAGGCGATTGATGATGGTTTTAAACCGTTATTGTTGTAATCCGTGA

mRNA sequence

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Protein sequence

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MIVWIGAIHNFHFPDDRWPMTFKLLSVKGLPPWANTSCVRITDVIQRKKPANWVYQNSSARGCAFEDELVDYLSALKCPRQQGCVKCGYYVTKFMREILHNPKTLIAALF
NTKNPFTQEQLDEVFRMWDLNYCNKYVAGGVDKDVGFAGFSDNRTTSLFSNGSHPSPNFSSHNRSAYLLLLIFCLFTFSNYFSIFLCGKKVGHLLQCGSEAIHNFHFPDD
RWPMTFKLLSVKGLPPWANTSCVRITDVIQRKKPANWVYQNSSARGCAFEDELVDYLSALKCPRQQGCVKCGYYVTKFMREILHNPKTLIAALFNTKNPFTQEQLDEVFR
MWDLNYCNKYVAGGVDKDVGFAGFSDNRTTSLFSNGSHPSPNFSSHNRSAYLLLLIFCLFTFSNYFSIFLCGKKVGHLLQCGSEAIHNFHFPDDRWPMTFKLLSVKGLPP
WANTSCVRITDVIQRKKPANWVYQNSSARGCAFEDELVDYLSALKCPRQQGCVKCGYYVTKFMREILHNPKTLIAALFNTKNPFTQEQLDEVFRMWDLNYCNKYVAGGVD
KDVGFETVIVVIRDRIGKSQRRLMMVLNRYCCNP

Lag0010517 (gene) of Sponge gourd (AG-4) v1 genome