CuGenDBv2

Gene ID	Lag0015765
Organism	Luffa acutangula AG-4 (Sponge gourd (AG-4) v1)
Description	Nicalin
Genome location	chr12:23369568..23374046
RNA-Seq Expression	Lag0015765
Synteny	Lag0015765
Gene Ontology terms	GO:0009966 - regulation of signal transduction (biological process) GO:0005789 - endoplasmic reticulum membrane (cellular component)
InterPro domains	IPR016574 - Nicalin

Homology

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GenBank top hits

e value

%identity

Alignment

XP_008463652.1 PREDICTED: nicalin-1 [Cucumis melo]

2.7e-55

68.97

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Query:  IPSSVTGVHQYTMISWLPGLKSDGDASHLPTIAIVASYDTFGAAPELSVSGSDSNGSGIVALLEIARLFSQPYE------------------------AR
        I S++T +       WLPGLKSDGDAS LPTIAIVASYDTFGAAPELSV GSDSNGSGIVALLEIARLFS  Y                           
Subjt:  IPSSVTGVHQYTMISWLPGLKSDGDASHLPTIAIVASYDTFGAAPELSVSGSDSNGSGIVALLEIARLFSQPYE------------------------AR

Query:  KLLQGFDHRFRESIDYTICLNNIGSWDEKLWLYVSKPPENAYIKQIFEDFSNVAEDLGFKFDMKHKEINISNPR
        K LQ FDHR RE IDY ICLN+IGSWD+KLWL+VSKPPENAYIKQIFEDFSNVAEDLGFK D+KHK+INISNPR
Subjt:  KLLQGFDHRFRESIDYTICLNNIGSWDEKLWLYVSKPPENAYIKQIFEDFSNVAEDLGFKFDMKHKEINISNPR

XP_022927448.1 nicalin-1-like [Cucurbita moschata]

2.1e-55

68.39

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Query:  IPSSVTGVHQYTMISWLPGLKSDGDASHLPTIAIVASYDTFGAAPELSVSGSDSNGSGIVALLEIARLFSQPYE------------------------AR
        + S++T +       WLPGLKSDGDA+ LPTIAIVASYDTFGAAPELSV GSDSNGSGIVALLEIARLFS  Y                           
Subjt:  IPSSVTGVHQYTMISWLPGLKSDGDASHLPTIAIVASYDTFGAAPELSVSGSDSNGSGIVALLEIARLFSQPYE------------------------AR

Query:  KLLQGFDHRFRESIDYTICLNNIGSWDEKLWLYVSKPPENAYIKQIFEDFSNVAEDLGFKFDMKHKEINISNPR
        K LQ FDHR RESIDY ICLN+IGSWD+KLWL+VSKPPENAYIKQIFEDFSNVAEDLGFK D+KHK+INISNPR
Subjt:  KLLQGFDHRFRESIDYTICLNNIGSWDEKLWLYVSKPPENAYIKQIFEDFSNVAEDLGFKFDMKHKEINISNPR

XP_023520704.1 nicalin-1-like [Cucurbita pepo subsp. pepo]

1.6e-55

68.39

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Query:  IPSSVTGVHQYTMISWLPGLKSDGDASHLPTIAIVASYDTFGAAPELSVSGSDSNGSGIVALLEIARLFSQPYEA------------------------R
        + S++T +       WLPGLKSDGDA+ LPTIAIVASYDTFGAAPELSV GSDSNGSGIVALLEIARLFS  Y +                         
Subjt:  IPSSVTGVHQYTMISWLPGLKSDGDASHLPTIAIVASYDTFGAAPELSVSGSDSNGSGIVALLEIARLFSQPYEA------------------------R

Query:  KLLQGFDHRFRESIDYTICLNNIGSWDEKLWLYVSKPPENAYIKQIFEDFSNVAEDLGFKFDMKHKEINISNPR
        K LQ FDHR RESIDY ICLN+IGSWD+KLWL+VSKPPENAYIKQIFEDFSNVAEDLGFK D+KHK+INISNPR
Subjt:  KLLQGFDHRFRESIDYTICLNNIGSWDEKLWLYVSKPPENAYIKQIFEDFSNVAEDLGFKFDMKHKEINISNPR

XP_038894419.1 nicalin-1 isoform X1 [Benincasa hispida]

1.2e-55

68.39

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Query:  IPSSVTGVHQYTMISWLPGLKSDGDASHLPTIAIVASYDTFGAAPELSVSGSDSNGSGIVALLEIARLFSQPYE------------------------AR
        + S++T +       WLPGLKSDGDAS LPTIAIVASYDTFGAAPELSV GSDSNGSG+VALLEIARLFS  Y                           
Subjt:  IPSSVTGVHQYTMISWLPGLKSDGDASHLPTIAIVASYDTFGAAPELSVSGSDSNGSGIVALLEIARLFSQPYE------------------------AR

Query:  KLLQGFDHRFRESIDYTICLNNIGSWDEKLWLYVSKPPENAYIKQIFEDFSNVAEDLGFKFDMKHKEINISNPR
        K LQ FDHR RESIDY ICLN+IGSWD+KLWL+VSKPPENAYIKQIFEDFSNVAEDLGFK D+KHK+INISNPR
Subjt:  KLLQGFDHRFRESIDYTICLNNIGSWDEKLWLYVSKPPENAYIKQIFEDFSNVAEDLGFKFDMKHKEINISNPR

XP_038894420.1 nicalin-1 isoform X2 [Benincasa hispida]

1.2e-55

68.39

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Query:  IPSSVTGVHQYTMISWLPGLKSDGDASHLPTIAIVASYDTFGAAPELSVSGSDSNGSGIVALLEIARLFSQPYE------------------------AR
        + S++T +       WLPGLKSDGDAS LPTIAIVASYDTFGAAPELSV GSDSNGSG+VALLEIARLFS  Y                           
Subjt:  IPSSVTGVHQYTMISWLPGLKSDGDASHLPTIAIVASYDTFGAAPELSVSGSDSNGSGIVALLEIARLFSQPYE------------------------AR

Query:  KLLQGFDHRFRESIDYTICLNNIGSWDEKLWLYVSKPPENAYIKQIFEDFSNVAEDLGFKFDMKHKEINISNPR
        K LQ FDHR RESIDY ICLN+IGSWD+KLWL+VSKPPENAYIKQIFEDFSNVAEDLGFK D+KHK+INISNPR
Subjt:  KLLQGFDHRFRESIDYTICLNNIGSWDEKLWLYVSKPPENAYIKQIFEDFSNVAEDLGFKFDMKHKEINISNPR

TrEMBL top hits

e value

%identity

Alignment

A0A0A0LYB7 Uncharacterized protein

3.9e-55

67.82

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Query:  IPSSVTGVHQYTMISWLPGLKSDGDASHLPTIAIVASYDTFGAAPELSVSGSDSNGSGIVALLEIARLFSQPYE------------------------AR
        + S++T +       WLPGLKSDGDAS LPTIAIVASYDTFGAAP+LSV GSDSNGSGIVALLEIARLFS  Y                           
Subjt:  IPSSVTGVHQYTMISWLPGLKSDGDASHLPTIAIVASYDTFGAAPELSVSGSDSNGSGIVALLEIARLFSQPYE------------------------AR

Query:  KLLQGFDHRFRESIDYTICLNNIGSWDEKLWLYVSKPPENAYIKQIFEDFSNVAEDLGFKFDMKHKEINISNPR
        K LQ FDHR RE IDY ICLN+IGSWD+KLWL+VSKPPENAYIKQIFEDFSNVAEDLGFK D+KHK+INISNPR
Subjt:  KLLQGFDHRFRESIDYTICLNNIGSWDEKLWLYVSKPPENAYIKQIFEDFSNVAEDLGFKFDMKHKEINISNPR

A0A1S3CJR5 nicalin-1

1.3e-55

68.97

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Query:  IPSSVTGVHQYTMISWLPGLKSDGDASHLPTIAIVASYDTFGAAPELSVSGSDSNGSGIVALLEIARLFSQPYE------------------------AR
        I S++T +       WLPGLKSDGDAS LPTIAIVASYDTFGAAPELSV GSDSNGSGIVALLEIARLFS  Y                           
Subjt:  IPSSVTGVHQYTMISWLPGLKSDGDASHLPTIAIVASYDTFGAAPELSVSGSDSNGSGIVALLEIARLFSQPYE------------------------AR

Query:  KLLQGFDHRFRESIDYTICLNNIGSWDEKLWLYVSKPPENAYIKQIFEDFSNVAEDLGFKFDMKHKEINISNPR
        K LQ FDHR RE IDY ICLN+IGSWD+KLWL+VSKPPENAYIKQIFEDFSNVAEDLGFK D+KHK+INISNPR
Subjt:  KLLQGFDHRFRESIDYTICLNNIGSWDEKLWLYVSKPPENAYIKQIFEDFSNVAEDLGFKFDMKHKEINISNPR

A0A5A7T1R9 Nicalin-1

1.3e-55

68.97

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Query:  IPSSVTGVHQYTMISWLPGLKSDGDASHLPTIAIVASYDTFGAAPELSVSGSDSNGSGIVALLEIARLFSQPYE------------------------AR
        I S++T +       WLPGLKSDGDAS LPTIAIVASYDTFGAAPELSV GSDSNGSGIVALLEIARLFS  Y                           
Subjt:  IPSSVTGVHQYTMISWLPGLKSDGDASHLPTIAIVASYDTFGAAPELSVSGSDSNGSGIVALLEIARLFSQPYE------------------------AR

Query:  KLLQGFDHRFRESIDYTICLNNIGSWDEKLWLYVSKPPENAYIKQIFEDFSNVAEDLGFKFDMKHKEINISNPR
        K LQ FDHR RE IDY ICLN+IGSWD+KLWL+VSKPPENAYIKQIFEDFSNVAEDLGFK D+KHK+INISNPR
Subjt:  KLLQGFDHRFRESIDYTICLNNIGSWDEKLWLYVSKPPENAYIKQIFEDFSNVAEDLGFKFDMKHKEINISNPR

A0A6J1EL15 nicalin-1-like

1.0e-55

68.39

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Query:  IPSSVTGVHQYTMISWLPGLKSDGDASHLPTIAIVASYDTFGAAPELSVSGSDSNGSGIVALLEIARLFSQPYE------------------------AR
        + S++T +       WLPGLKSDGDA+ LPTIAIVASYDTFGAAPELSV GSDSNGSGIVALLEIARLFS  Y                           
Subjt:  IPSSVTGVHQYTMISWLPGLKSDGDASHLPTIAIVASYDTFGAAPELSVSGSDSNGSGIVALLEIARLFSQPYE------------------------AR

Query:  KLLQGFDHRFRESIDYTICLNNIGSWDEKLWLYVSKPPENAYIKQIFEDFSNVAEDLGFKFDMKHKEINISNPR
        K LQ FDHR RESIDY ICLN+IGSWD+KLWL+VSKPPENAYIKQIFEDFSNVAEDLGFK D+KHK+INISNPR
Subjt:  KLLQGFDHRFRESIDYTICLNNIGSWDEKLWLYVSKPPENAYIKQIFEDFSNVAEDLGFKFDMKHKEINISNPR

A0A6J1IC52 nicalin-1-like

3.9e-55

67.82

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Query:  IPSSVTGVHQYTMISWLPGLKSDGDASHLPTIAIVASYDTFGAAPELSVSGSDSNGSGIVALLEIARLFSQPYEA------------------------R
        + S++T +       WLPGLK DGDAS LPTIAIVASYDTFGA+PELSV GSDSNGSGIVALLEIARLFS  Y +                         
Subjt:  IPSSVTGVHQYTMISWLPGLKSDGDASHLPTIAIVASYDTFGAAPELSVSGSDSNGSGIVALLEIARLFSQPYEA------------------------R

Query:  KLLQGFDHRFRESIDYTICLNNIGSWDEKLWLYVSKPPENAYIKQIFEDFSNVAEDLGFKFDMKHKEINISNPR
        K LQ FDHR RESIDY ICLN+IGSWD+KLWL+VSKPPENAYIKQIFEDFSNVAEDLGFK D+KHK+INISNPR
Subjt:  KLLQGFDHRFRESIDYTICLNNIGSWDEKLWLYVSKPPENAYIKQIFEDFSNVAEDLGFKFDMKHKEINISNPR

SwissProt top hits

e value

%identity

Alignment

Q5XIA1 Nicalin

1.2e-13

36.84

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Query:  LPTIAIVASYDTFGAAPELSVSGSDSNGSGIVALLEIARLFSQPYEARKL-----------------LQGFDHRFRESIDYT------------ICLNNI
        LPTI IVA YD FG AP LS+ G+DSNGSGI  LLE+ARLFS+ Y  ++                   QG      +S+D+T            +CL+ +
Subjt:  LPTIAIVASYDTFGAAPELSVSGSDSNGSGIVALLEIARLFSQPYEARKL-----------------LQGFDHRFRESIDYT------------ICLNNI

Query:  GSWDEKLWLYVSKPPENAYIKQIF-EDFSNVA--EDLGFKFDMKHKEINISN
        G     L L+VSKPP    ++ +F  +   VA  +     F M HK+IN+++
Subjt:  GSWDEKLWLYVSKPPENAYIKQIF-EDFSNVA--EDLGFKFDMKHKEINISN

Q5ZJH2 Nicalin

9.2e-14

35.1

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Query:  LPTIAIVASYDTFGAAPELSVSGSDSNGSGIVALLEIARLFSQPYEARKLLQGF-------------------------DHR----FRESIDYTICLNNI
        LPT+ IVA YD+FG AP LS  G+DSNGSG+  LLE+ARLFS+ Y  R+   G+                         DH      ++++ + +CL+ +
Subjt:  LPTIAIVASYDTFGAAPELSVSGSDSNGSGIVALLEIARLFSQPYEARKLLQGF-------------------------DHR----FRESIDYTICLNNI

Query:  GSWDEKLWLYVSKPPENAYIKQIFEDFSNVAEDLGF---KFDMKHKEINIS
        G     L L+VSKPP+   ++  F     +     F   KF M HK+IN++
Subjt:  GSWDEKLWLYVSKPPENAYIKQIFEDFSNVAEDLGF---KFDMKHKEINIS

Q6NZ07 Nicalin-1

1.1e-14

31.08

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Query:  ISWLPGLKSDGDASHLPTIAIVASYDTFGAAPELSVSGSDSNGSGIVALLEIARLFSQPYEARKLLQGF-------------------------DHR---
        I+ L G  +      LPTI +VA YD+FG AP LS  G+DSNGSG+  LLE+ARLFS+ Y  ++   G+                         DH    
Subjt:  ISWLPGLKSDGDASHLPTIAIVASYDTFGAAPELSVSGSDSNGSGIVALLEIARLFSQPYEARKLLQGF-------------------------DHR---

Query:  -FRESIDYTICLNNIGSWDEKLWLYVSKPPEN-----AYIKQIFEDFSNVAEDLGFKFDMKHKEINISNP------------RDPPGTLGFLECVSTPMT
          ++++ + +CL+ +G+ D  L L+VSKPP+        +K++    ++   DL  KF M HK+IN+++             R P  TL  LE   +P  
Subjt:  -FRESIDYTICLNNIGSWDEKLWLYVSKPPEN-----AYIKQIFEDFSNVAEDLGFKFDMKHKEINISNP------------RDPPGTLGFLECVSTPMT

Query:  CYRSSTRQLAISSSVTGVHQYT
           S     ++S S+ G  + T
Subjt:  CYRSSTRQLAISSSVTGVHQYT

Q8VCM8 Nicalin

2.1e-13

36.84

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Query:  LPTIAIVASYDTFGAAPELSVSGSDSNGSGIVALLEIARLFSQPYEARKL-----------------LQGFDHRFRESIDYT------------ICLNNI
        LPTI IVA YD FG AP LS+ G+DSNGSGI  LLE+ARLFS+ Y  ++                   QG      +S+D+T            +CL+ +
Subjt:  LPTIAIVASYDTFGAAPELSVSGSDSNGSGIVALLEIARLFSQPYEARKL-----------------LQGFDHRFRESIDYT------------ICLNNI

Query:  GSWDEKLWLYVSKPPENAYIKQIF-EDFSNVA--EDLGFKFDMKHKEINISN
        G     L L+VSKPP    ++  F  +   VA  +     F M HK+IN+++
Subjt:  GSWDEKLWLYVSKPPENAYIKQIF-EDFSNVA--EDLGFKFDMKHKEINISN

Q969V3 Nicalin

7.1e-14

32.58

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Query:  TGVHQYTMISWL----PGLKSDGDASHLPTIAIVASYDTFGAAPELSVSGSDSNGSGIVALLEIARLFSQPYEARK------------------------
        +GV    +  WL     G  +      LPTI IVA YD FG AP LS+ G+DSNGSG+  LLE+ARLFS+ Y  ++                        
Subjt:  TGVHQYTMISWL----PGLKSDGDASHLPTIAIVASYDTFGAAPELSVSGSDSNGSGIVALLEIARLFSQPYEARK------------------------

Query:  -LLQGFDHR----FRESIDYTICLNNIGSWDEKLWLYVSKPPENAYIKQIF-EDFSNVA--EDLGFKFDMKHKEINIS
         L    DH      ++++ + +CL+ +G     L L+VSKPP    ++  F  +   VA  +    +F M HK IN++
Subjt:  -LLQGFDHR----FRESIDYTICLNNIGSWDEKLWLYVSKPPENAYIKQIF-EDFSNVA--EDLGFKFDMKHKEINIS

Arabidopsis top hits

e value

%identity

Alignment

AT3G44330.1 INVOLVED IN: protein processing; LOCATED IN: mitochondrion, endoplasmic reticulum, plasma membrane, vacuole; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Nicalin (InterPro:IPR016574), EF-Hand 1, calcium-binding site (InterPro:IPR018247), Nicastrin (InterPro:IPR008710); Has 245 Blast hits to 243 proteins in 99 species: Archae - 6; Bacteria - 10; Metazoa - 139; Fungi - 0; Plants - 46; Viruses - 0; Other Eukaryotes - 44 (source: NCBI BLink).

2.4e-49

56.91

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Query:  SGTRQLAIPSSVTGVHQYTMISWLPGLKSDGDASHLPTIAIVASYDTFGAAPELSVSGSDSNGSGIVALLEIARLFSQPYE-------------------
        S  R++A P ++T +       WLPGL+++GD+S LPTIA+VASYDTFGAAP LSV GSDSNGSG+VALLE+ARLFS  Y                    
Subjt:  SGTRQLAIPSSVTGVHQYTMISWLPGLKSDGDASHLPTIAIVASYDTFGAAPELSVSGSDSNGSGIVALLEIARLFSQPYE-------------------

Query:  -----ARKLLQGFDHRFRESIDYTICLNNIGSWDEKLWLYVSKPPENAYIKQIFEDFSNVAEDLGFKFDMKHKEINISNPR
              +K L+  D R RESIDY ICLN++GSWD +L ++VSKPP+NAYIKQIFE FSNVAEDLGF+  +KHK+INISN R
Subjt:  -----ARKLLQGFDHRFRESIDYTICLNNIGSWDEKLWLYVSKPPENAYIKQIFEDFSNVAEDLGFKFDMKHKEINISNPR

Sequences

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CDS sequence

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ATGAAGTGTGACCGATCAGGCACTAGGCAACTGGCTATCCCTAGCTCAGTCACTGGCGTTCACCAATACACAATGATCAGTTGGCTGCCTGGATTAAAATCTGATGGAGA
TGCTAGTCACCTCCCAACAATTGCTATTGTAGCATCATATGATACATTCGGCGCTGCTCCTGAATTATCTGTGTCGGGGAGCGATAGCAATGGAAGTGGAATTGTTGCAC
TTCTTGAAATTGCAAGGTTATTTTCTCAACCTTATGAAGCGAGGAAGTTGCTTCAAGGCTTTGATCACCGTTTCCGTGAGAGTATTGACTATACTATTTGCTTAAATAAT
ATTGGCTCATGGGATGAAAAATTATGGCTGTATGTCTCCAAGCCTCCAGAAAATGCCTACATCAAGCAAATCTTTGAAGATTTCTCAAATGTTGCTGAGGATTTGGGCTT
TAAATTTGATATGAAGCACAAGGAGATAAATATTTCGAACCCTCGAGATCCTCCCGGAACTCTGGGTTTTTTGGAATGTGTTTCAACTCCAATGACGTGCTACCGATCAA
GCACTAGGCAACTAGCTATCTCTAGCTCAGTCACTGGCGTTCACCAATACACAATGATATAG

mRNA sequence

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Protein sequence

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MKCDRSGTRQLAIPSSVTGVHQYTMISWLPGLKSDGDASHLPTIAIVASYDTFGAAPELSVSGSDSNGSGIVALLEIARLFSQPYEARKLLQGFDHRFRESIDYTICLNN
IGSWDEKLWLYVSKPPENAYIKQIFEDFSNVAEDLGFKFDMKHKEINISNPRDPPGTLGFLECVSTPMTCYRSSTRQLAISSSVTGVHQYTMI

Lag0015765 (gene) of Sponge gourd (AG-4) v1 genome