CuGenDBv2

Gene ID	Lag0017113
Organism	Luffa acutangula AG-4 (Sponge gourd (AG-4) v1)
Description	3-hydroxy-3-methylglutaryl-coenzyme A reductase
Genome location	chr5:310151..310546
RNA-Seq Expression	Lag0017113
Synteny	Lag0017113
Gene Ontology terms	GO:0008299 - isoprenoid biosynthetic process (biological process) GO:0015936 - coenzyme A metabolic process (biological process) GO:0016126 - sterol biosynthetic process (biological process) GO:0005778 - peroxisomal membrane (cellular component) GO:0005789 - endoplasmic reticulum membrane (cellular component) GO:0016021 - integral component of membrane (cellular component) GO:0004420 - hydroxymethylglutaryl-CoA reductase (NADPH) activity (molecular function)
InterPro domains	IPR002202 - Hydroxymethylglutaryl-CoA reductase, class I/II IPR009029 - Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain superfamily IPR023074 - Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain superfamily IPR023076 - Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site

Homology

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GenBank top hits

e value

%identity

Alignment

PIA56946.1 hypothetical protein AQUCO_00700952v1 [Aquilegia coerulea]

5.3e-28

78.57

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Query:  LTVVNFGWDGSRSTNSIVCFQVGTVGGGTQLASQSACLDLLGVRGASKEAPGSNSRLLATIVAGSVLAGELSLMSALAAGQLVKSHMKYNRSTNDVSK
        +  VN G D   S  S+   +VGTVGGGTQLASQSACL+LLGV+GASKEAPGSNSRLLA+IVAGSVLAGELSLMSALAAGQLVKSHMKYNRS+ D+SK
Subjt:  LTVVNFGWDGSRSTNSIVCFQVGTVGGGTQLASQSACLDLLGVRGASKEAPGSNSRLLATIVAGSVLAGELSLMSALAAGQLVKSHMKYNRSTNDVSK

RVW78829.1 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1 [Vitis vinifera]

8.3e-29

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Query:  CFQVGTVGGGTQLASQSACLDLLGVRGASKEAPGSNSRLLATIVAGSVLAGELSLMSALAAGQLVKSHMKYNRSTNDVSK
        C QVGTVGGGTQLASQSACL+LLGV+GASKE+PGSNSRLLATIVAGSVLAGELSLMSA+AAGQLVKSH+KYNRS+ DVSK
Subjt:  CFQVGTVGGGTQLASQSACLDLLGVRGASKEAPGSNSRLLATIVAGSVLAGELSLMSALAAGQLVKSHMKYNRSTNDVSK

XP_010266284.1 PREDICTED: 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1-like [Nelumbo nucifera]

4.1e-28

78.57

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Query:  LTVVNFGWDGSRSTNSIVCFQVGTVGGGTQLASQSACLDLLGVRGASKEAPGSNSRLLATIVAGSVLAGELSLMSALAAGQLVKSHMKYNRSTNDVSK
        +  VN G D   S  S+   +VGTVGGGTQLASQSACL+LLGV+GASKE+PGSNSRLLAT+VAGSVLAGELSLMSALAAGQLVKSHMKYNRS+ DVSK
Subjt:  LTVVNFGWDGSRSTNSIVCFQVGTVGGGTQLASQSACLDLLGVRGASKEAPGSNSRLLATIVAGSVLAGELSLMSALAAGQLVKSHMKYNRSTNDVSK

XP_027919759.1 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1-like [Vigna unguiculata]

4.1e-28

87.65

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Query:  QVGTVGGGTQLASQSACLDLLGVRGASKEAPGSNSRLLATIVAGSVLAGELSLMSALAAGQLVKSHMKYNRSTNDVSKYLP
        +VGTVGGGTQLASQSACL+LLGV+GASKE PG+NSRLLATIVAGSVLAGELSLMSA+AAGQLVKSHMKYNRS  D+SK LP
Subjt:  QVGTVGGGTQLASQSACLDLLGVRGASKEAPGSNSRLLATIVAGSVLAGELSLMSALAAGQLVKSHMKYNRSTNDVSKYLP

XP_030539496.1 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1-like [Rhodamnia argentea]

5.3e-28

91.03

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Query:  QVGTVGGGTQLASQSACLDLLGVRGASKEAPGSNSRLLATIVAGSVLAGELSLMSALAAGQLVKSHMKYNRSTNDVSK
        +VGTVGGGTQLASQSACL+LLGV+GA++EAPGSNSRLLAT+VAGSVLAGELSLMSALAAGQLVKSHMKYNRST DVSK
Subjt:  QVGTVGGGTQLASQSACLDLLGVRGASKEAPGSNSRLLATIVAGSVLAGELSLMSALAAGQLVKSHMKYNRSTNDVSK

TrEMBL top hits

e value

%identity

Alignment

A0A1U8AT56 3-hydroxy-3-methylglutaryl coenzyme A reductase

2.0e-28

78.57

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Query:  LTVVNFGWDGSRSTNSIVCFQVGTVGGGTQLASQSACLDLLGVRGASKEAPGSNSRLLATIVAGSVLAGELSLMSALAAGQLVKSHMKYNRSTNDVSK
        +  VN G D   S  S+   +VGTVGGGTQLASQSACL+LLGV+GASKE+PGSNSRLLAT+VAGSVLAGELSLMSALAAGQLVKSHMKYNRS+ DVSK
Subjt:  LTVVNFGWDGSRSTNSIVCFQVGTVGGGTQLASQSACLDLLGVRGASKEAPGSNSRLLATIVAGSVLAGELSLMSALAAGQLVKSHMKYNRSTNDVSK

A0A2G5EME1 3-hydroxy-3-methylglutaryl coenzyme A reductase

2.6e-28

78.57

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Query:  LTVVNFGWDGSRSTNSIVCFQVGTVGGGTQLASQSACLDLLGVRGASKEAPGSNSRLLATIVAGSVLAGELSLMSALAAGQLVKSHMKYNRSTNDVSK
        +  VN G D   S  S+   +VGTVGGGTQLASQSACL+LLGV+GASKEAPGSNSRLLA+IVAGSVLAGELSLMSALAAGQLVKSHMKYNRS+ D+SK
Subjt:  LTVVNFGWDGSRSTNSIVCFQVGTVGGGTQLASQSACLDLLGVRGASKEAPGSNSRLLATIVAGSVLAGELSLMSALAAGQLVKSHMKYNRSTNDVSK

A0A438H358 Hydroxymethylglutaryl-CoA reductase (NADPH)

4.0e-29

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Query:  CFQVGTVGGGTQLASQSACLDLLGVRGASKEAPGSNSRLLATIVAGSVLAGELSLMSALAAGQLVKSHMKYNRSTNDVSK
        C QVGTVGGGTQLASQSACL+LLGV+GASKE+PGSNSRLLATIVAGSVLAGELSLMSA+AAGQLVKSH+KYNRS+ DVSK
Subjt:  CFQVGTVGGGTQLASQSACLDLLGVRGASKEAPGSNSRLLATIVAGSVLAGELSLMSALAAGQLVKSHMKYNRSTNDVSK

A0A4D6L123 3-hydroxy-3-methylglutaryl coenzyme A reductase

2.0e-28

87.65

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Query:  QVGTVGGGTQLASQSACLDLLGVRGASKEAPGSNSRLLATIVAGSVLAGELSLMSALAAGQLVKSHMKYNRSTNDVSKYLP
        +VGTVGGGTQLASQSACL+LLGV+GASKE PG+NSRLLATIVAGSVLAGELSLMSA+AAGQLVKSHMKYNRS  D+SK LP
Subjt:  QVGTVGGGTQLASQSACLDLLGVRGASKEAPGSNSRLLATIVAGSVLAGELSLMSALAAGQLVKSHMKYNRSTNDVSKYLP

A0A7J6WDH5 3-hydroxy-3-methylglutaryl coenzyme A reductase

2.6e-28

78.57

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Query:  LTVVNFGWDGSRSTNSIVCFQVGTVGGGTQLASQSACLDLLGVRGASKEAPGSNSRLLATIVAGSVLAGELSLMSALAAGQLVKSHMKYNRSTNDVSK
        +  VN G D   S  S+   +VGTVGGGTQLASQSACL+LLGV+GASKEAPGSNSRLLA+IVAGSVLAGELSLMSALAAGQLVKSHMKYNRS+ D+SK
Subjt:  LTVVNFGWDGSRSTNSIVCFQVGTVGGGTQLASQSACLDLLGVRGASKEAPGSNSRLLATIVAGSVLAGELSLMSALAAGQLVKSHMKYNRSTNDVSK

SwissProt top hits

e value

%identity

Alignment

A0A0A1C930 3-hydroxy-3-methylglutaryl coenzyme A reductase 2-A

5.9e-30

88.46

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Query:  QVGTVGGGTQLASQSACLDLLGVRGASKEAPGSNSRLLATIVAGSVLAGELSLMSALAAGQLVKSHMKYNRSTNDVSK
        +VGTVGGGTQLASQSACL+LLGV+GASKE+PGSNSRLLA+IVAGSVLAGELSLMSALAAGQLVKSHMKYNRS+ D++K
Subjt:  QVGTVGGGTQLASQSACLDLLGVRGASKEAPGSNSRLLATIVAGSVLAGELSLMSALAAGQLVKSHMKYNRSTNDVSK

P29057 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1

2.3e-29

87.18

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Query:  QVGTVGGGTQLASQSACLDLLGVRGASKEAPGSNSRLLATIVAGSVLAGELSLMSALAAGQLVKSHMKYNRSTNDVSK
        +VGTVGGGTQLASQSACL+LLGV+GA+KE+PGSNSRLLA IVAGSVLAGELSLMSA+AAGQLVKSHMKYNRS+ D+SK
Subjt:  QVGTVGGGTQLASQSACLDLLGVRGASKEAPGSNSRLLATIVAGSVLAGELSLMSALAAGQLVKSHMKYNRSTNDVSK

P48021 3-hydroxy-3-methylglutaryl-coenzyme A reductase

1.3e-29

88.46

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Query:  QVGTVGGGTQLASQSACLDLLGVRGASKEAPGSNSRLLATIVAGSVLAGELSLMSALAAGQLVKSHMKYNRSTNDVSK
        +VGTVGGGTQLASQSACL+LLGV+GASKEAPGSN+RLLATIVAGSVLAGELSLMSA+AAGQLV SHMKYNRS  DV+K
Subjt:  QVGTVGGGTQLASQSACLDLLGVRGASKEAPGSNSRLLATIVAGSVLAGELSLMSALAAGQLVKSHMKYNRSTNDVSK

Q00583 3-hydroxy-3-methylglutaryl-coenzyme A reductase 3

1.7e-29

75.51

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Query:  LTVVNFGWDGSRSTNSIVCFQVGTVGGGTQLASQSACLDLLGVRGASKEAPGSNSRLLATIVAGSVLAGELSLMSALAAGQLVKSHMKYNRSTNDVSK
        +  VN G D   S  S+   ++GTVGGGTQLASQSACL+LLGV+GASK++PGSNSRLLATIVAGSVLAGELSLMSA+AAGQLV SHMKYNRS  DVSK
Subjt:  LTVVNFGWDGSRSTNSIVCFQVGTVGGGTQLASQSACLDLLGVRGASKEAPGSNSRLLATIVAGSVLAGELSLMSALAAGQLVKSHMKYNRSTNDVSK

U5JCC6 3-hydroxy-3-methylglutaryl coenzyme A reductase 2-B

2.3e-29

88.46

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Query:  QVGTVGGGTQLASQSACLDLLGVRGASKEAPGSNSRLLATIVAGSVLAGELSLMSALAAGQLVKSHMKYNRSTNDVSK
        +VGTVGGGTQLASQSACL+LLGV+GASKE+PG NSRLLA+IVAGSVLAGELSLMSALAAGQLVKSHMK+NRS+ DVSK
Subjt:  QVGTVGGGTQLASQSACLDLLGVRGASKEAPGSNSRLLATIVAGSVLAGELSLMSALAAGQLVKSHMKYNRSTNDVSK

Arabidopsis top hits

e value

%identity

Alignment

AT1G76490.1 hydroxy methylglutaryl CoA reductase 1

3.3e-28

81.82

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Query:  QVGTVGGGTQLASQSACLDLLGVRGASKEAPGSNSRLLATIVAGSVLAGELSLMSALAAGQLVKSHMKYNRSTNDVS
        +VGTVGGGTQLASQSACL+LLGV+GAS E+PG N+R LATIVAG+VLAGELSLMSA+AAGQLV+SHMKYNRS+ D+S
Subjt:  QVGTVGGGTQLASQSACLDLLGVRGASKEAPGSNSRLLATIVAGSVLAGELSLMSALAAGQLVKSHMKYNRSTNDVS

AT2G17370.1 3-hydroxy-3-methylglutaryl-CoA reductase 2

5.7e-28

76.54

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Query:  SIVCFQVGTVGGGTQLASQSACLDLLGVRGASKEAPGSNSRLLATIVAGSVLAGELSLMSALAAGQLVKSHMKYNRSTNDV
        S+ C +VGTVGGGTQLASQ+ACL+LLGV+G++ E PGSN++ LA IVAGSVLAGELSLMSA+AAGQLVKSHMKYNRS+ D+
Subjt:  SIVCFQVGTVGGGTQLASQSACLDLLGVRGASKEAPGSNSRLLATIVAGSVLAGELSLMSALAAGQLVKSHMKYNRSTNDV

Sequences

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CDS sequence

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ATGCATGGTATCCTCCAGAAGAACCCAGCCAAGAGCCAACAATATCTTGAAACTGAAAGTCTGACTGACATGCATGCCACGTTAACCGTAGTTAATTTTGGATGGGATGG
GTCAAGGTCGACTAACTCAATTGTTTGCTTCCAGGTGGGTACGGTTGGGGGTGGGACTCAACTGGCATCGCAGTCAGCTTGTCTGGACCTACTTGGAGTGAGGGGAGCCA
GCAAGGAAGCCCCAGGCTCCAACTCTAGGCTGCTCGCAACCATAGTGGCTGGCTCTGTCCTGGCTGGGGAACTTTCGCTTATGTCGGCTCTGGCGGCTGGGCAGCTTGTA
AAGAGTCACATGAAGTACAATAGGTCTACCAATGATGTCTCTAAATACTTACCAAGGCCTACTTGA

mRNA sequence

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Protein sequence

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MHGILQKNPAKSQQYLETESLTDMHATLTVVNFGWDGSRSTNSIVCFQVGTVGGGTQLASQSACLDLLGVRGASKEAPGSNSRLLATIVAGSVLAGELSLMSALAAGQLV
KSHMKYNRSTNDVSKYLPRPT

Lag0017113 (gene) of Sponge gourd (AG-4) v1 genome