CuGenDBv2

Gene ID	Lag0018586
Organism	Luffa acutangula AG-4 (Sponge gourd (AG-4) v1)
Description	dihydrofolate synthetase isoform X1
Genome location	chr5:30044260..30056990
RNA-Seq Expression	Lag0018586
Synteny	Lag0018586
Gene Ontology terms	GO:0006761 - dihydrofolate biosynthetic process (biological process) GO:0009793 - embryo development ending in seed dormancy (biological process) GO:0046901 - tetrahydrofolylpolyglutamate biosynthetic process (biological process) GO:0005759 - mitochondrial matrix (cellular component) GO:0005829 - cytosol (cellular component) GO:0004326 - tetrahydrofolylpolyglutamate synthase activity (molecular function) GO:0005524 - ATP binding (molecular function) GO:0008841 - dihydrofolate synthase activity (molecular function) GO:0046872 - metal ion binding (molecular function)
InterPro domains	IPR001645 - Folylpolyglutamate synthetase IPR013221 - Mur ligase, central IPR018109 - Folylpolyglutamate synthetase, conserved site IPR036565 - Mur-like, catalytic domain superfamily IPR036615 - Mur ligase, C-terminal domain superfamily

Homology

Show/hide homology

GenBank top hits

e value

%identity

Alignment

KAG6576673.1 Dihydrofolate synthetase, partial [Cucurbita argyrosperma subsp. sororia]

1.3e-251

83.36

Show/hide

Query:  FKHHHHCPPQILGRLLLNYFAGERPSISRRIGSKQCFDTHSEDQEITEFMEYLDSLKNYEKLGVPRGAGTDSDDGFDLGRMRRMMERLGNPQSKFKTNGR
        FK+HHH  PQI GRLLLNYF GE PSIS RIGSKQCF  HSEDQ++TEFMEYLDSLKNYEKLGVP GAGT+S+DGFDLGRM+R+MERLGNPQSKFK    
Subjt:  FKHHHHCPPQILGRLLLNYFAGERPSISRRIGSKQCFDTHSEDQEITEFMEYLDSLKNYEKLGVPRGAGTDSDDGFDLGRMRRMMERLGNPQSKFKTNGR

Query:  IIIGHSHCGNQGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISLERSGEMVSGKALNSLFKRNKEFLDQSVELENGHISHFEVLTAMAFSLFAQEK
        I I     G +GKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISL RSGEMVSGKALN LFKRNKE LDQSV+LENG ISHFEVLTAMAFSLFAQE 
Subjt:  IIIGHSHCGNQGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISLERSGEMVSGKALNSLFKRNKEFLDQSVELENGHISHFEVLTAMAFSLFAQEK

Query:  VDVAVIEAGLGGARDATNIICSSRLAAAVITSIGEEYVAVLGGSLESIATAKAGIIKHGCPTILAGPFLPSIECILRDKALSMSSSVLSASDPGNKSTIK
        VDVAVIEAGLGGARDATNIICSSRLAAAVITSIGEE++A LGGSLESIA AKAGIIKHGCPTIL GPF+P+IECILRDKALSMSS V+SASDPGN+STIK
Subjt:  VDVAVIEAGLGGARDATNIICSSRLAAAVITSIGEEYVAVLGGSLESIATAKAGIIKHGCPTILAGPFLPSIECILRDKALSMSSSVLSASDPGNKSTIK

Query:  GVNLLNGRLCQCCDIVIQIDNE--SYWMSTSRMLGSHQLQNAATATCVILTLRNLGWRISDVSIRNGLEQTFLVGRSHFLSAEEAEILGLPGATILLDGA
        GV+LLNGRLCQCCD++IQ DNE    +    RMLG HQLQNAATATCVILTLRNLGWRIS+ SIR+GLE+TFLVGRSHFLSA+EA ILGLPG  ILLDGA
Subjt:  GVNLLNGRLCQCCDIVIQIDNE--SYWMSTSRMLGSHQLQNAATATCVILTLRNLGWRISDVSIRNGLEQTFLVGRSHFLSAEEAEILGLPGATILLDGA

Query:  HTKDSAKALVDTIQMTFPEARLALVVAMASDKDHIGFAREFLKGGKLESIVLTEANIGGAKSRTTSAALLRDCWIQASNELGISVSLETKDASVSSMSKL
        HTKDSAKALVDTIQM+FP+A+LALVVAMASDKDH GFA EFL+GGKLESIVL+EANIGG KSRTTSAALLRDCWIQASNE+GI +SLETKDA VSS SKL
Subjt:  HTKDSAKALVDTIQMTFPEARLALVVAMASDKDHIGFAREFLKGGKLESIVLTEANIGGAKSRTTSAALLRDCWIQASNELGISVSLETKDASVSSMSKL

Query:  ENRPILTTETSLLHAIKITVENLKQRTEGQQRGLIVVTGSLNAISMVLSSIHS
        ENRP+LTTETSLL AIKI  E LKQR +G +RGL+VVTGSL+A+SMVLSS+HS
Subjt:  ENRPILTTETSLLHAIKITVENLKQRTEGQQRGLIVVTGSLNAISMVLSSIHS

XP_022141068.1 dihydrofolate synthetase isoform X1 [Momordica charantia]

1.9e-253

84.99

Show/hide

Query:  FKHHHHCPPQILGRLLLNYFAGERPSISRRIGSKQCFDTHSEDQEITEFMEYLDSLKNYEKLGVPRGAGTDSDDGFDLGRMRRMMERLGNPQSKFKTNGR
        FK+H    PQILG LLLN+  GE PSIS RIGSKQCF THSED E+TEFMEYLDSLKNYEKLGVPRGAGTDSDDGFDLGRMRR+MERLGNPQSKFK    
Subjt:  FKHHHHCPPQILGRLLLNYFAGERPSISRRIGSKQCFDTHSEDQEITEFMEYLDSLKNYEKLGVPRGAGTDSDDGFDLGRMRRMMERLGNPQSKFKTNGR

Query:  IIIGHSHCGNQGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISLERSGEMVSGKALNSLFKRNKEFLDQSVELENGHISHFEVLTAMAFSLFAQEK
        I I     G +GKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISL RSGEMVSGKALNSLFKRNKEFLDQSVE ENG ISHFEVLTAMAFSLFAQE 
Subjt:  IIIGHSHCGNQGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISLERSGEMVSGKALNSLFKRNKEFLDQSVELENGHISHFEVLTAMAFSLFAQEK

Query:  VDVAVIEAGLGGARDATNIICSSRLAAAVITSIGEEYVAVLGGSLESIATAKAGIIKHGCPTILAGPFLPSIECILRDKALSMSSSVLSASDPGNKSTIK
        VDVAVIEAGLGGARDATNIICSSRLAAAVITSIGEE++A LGGSLESIA AKAGIIKHGCPTIL GPFLPSIECIL DKALSMSS V+SAS PG++STIK
Subjt:  VDVAVIEAGLGGARDATNIICSSRLAAAVITSIGEEYVAVLGGSLESIATAKAGIIKHGCPTILAGPFLPSIECILRDKALSMSSSVLSASDPGNKSTIK

Query:  GVNLLNGRLCQCCDIVIQIDNESYWM--STSRMLGSHQLQNAATATCVILTLRNLGWRISDVSIRNGLEQTFLVGRSHFLSAEEAEILGLPGATILLDGA
        GV+LL+GRLCQCCDIVIQIDNE   +     RMLG HQLQNAATATC ILTLRNLGWRISD SI+ GLEQTFLVGRSHFLSA+EA +LGLPGATILLDGA
Subjt:  GVNLLNGRLCQCCDIVIQIDNESYWM--STSRMLGSHQLQNAATATCVILTLRNLGWRISDVSIRNGLEQTFLVGRSHFLSAEEAEILGLPGATILLDGA

Query:  HTKDSAKALVDTIQMTFPEARLALVVAMASDKDHIGFAREFLKGGKLESIVLTEANIGGAKSRTTSAALLRDCWIQASNELGISVSLETKDASVSSMSKL
        HTKDSAKALVDTIQMTFPEARLALVVAMASDKDH+GFAREFL+GGKLESI+LTEANIGG KSRTTSAA+LRDCWIQA+NELGI +SLETKDA VSS SKL
Subjt:  HTKDSAKALVDTIQMTFPEARLALVVAMASDKDHIGFAREFLKGGKLESIVLTEANIGGAKSRTTSAALLRDCWIQASNELGISVSLETKDASVSSMSKL

Query:  ENRPILTTETSLLHAIKITVENLKQRTEGQQRGLIVVTGSLNAISMVLSSIHS
        E+RPILTTETSLLHA+KI  E LKQRTEG + GL VVTGSL+A+SMVLSS+HS
Subjt:  ENRPILTTETSLLHAIKITVENLKQRTEGQQRGLIVVTGSLNAISMVLSSIHS

XP_022922898.1 dihydrofolate synthetase isoform X1 [Cucurbita moschata]

1.3e-251

83.36

Show/hide

Query:  FKHHHHCPPQILGRLLLNYFAGERPSISRRIGSKQCFDTHSEDQEITEFMEYLDSLKNYEKLGVPRGAGTDSDDGFDLGRMRRMMERLGNPQSKFKTNGR
        FK+HHH  PQI GRLLLNYF GE PSIS RIGSKQCF  HSEDQ++TEFMEYLDSLKNYEKLGVP GAGTDS+DGFDLGRM+R+MERLGNPQSKFK    
Subjt:  FKHHHHCPPQILGRLLLNYFAGERPSISRRIGSKQCFDTHSEDQEITEFMEYLDSLKNYEKLGVPRGAGTDSDDGFDLGRMRRMMERLGNPQSKFKTNGR

Query:  IIIGHSHCGNQGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISLERSGEMVSGKALNSLFKRNKEFLDQSVELENGHISHFEVLTAMAFSLFAQEK
        I I     G +GKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISL RSGEMVSGKALN LFKRNKE LDQSV+LENG ISHFEVLTAMAFSLFAQE 
Subjt:  IIIGHSHCGNQGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISLERSGEMVSGKALNSLFKRNKEFLDQSVELENGHISHFEVLTAMAFSLFAQEK

Query:  VDVAVIEAGLGGARDATNIICSSRLAAAVITSIGEEYVAVLGGSLESIATAKAGIIKHGCPTILAGPFLPSIECILRDKALSMSSSVLSASDPGNKSTIK
        VDVAVIEAGLGGARDATNIICSSRLAAAVITSIGEE++A LGGSLESIA AKAGIIKHGCPTIL GPF+P+IECILRDKALSMSS V+SASDPGN+S+IK
Subjt:  VDVAVIEAGLGGARDATNIICSSRLAAAVITSIGEEYVAVLGGSLESIATAKAGIIKHGCPTILAGPFLPSIECILRDKALSMSSSVLSASDPGNKSTIK

Query:  GVNLLNGRLCQCCDIVIQIDNE--SYWMSTSRMLGSHQLQNAATATCVILTLRNLGWRISDVSIRNGLEQTFLVGRSHFLSAEEAEILGLPGATILLDGA
        GV+LLNGRLCQCCD++IQ DNE    +    RMLG HQLQNAATATCVILTLRNLGWRIS+ SIR+GLE+TFLVGRSHFLSA+EA ILGLPG  ILLDGA
Subjt:  GVNLLNGRLCQCCDIVIQIDNE--SYWMSTSRMLGSHQLQNAATATCVILTLRNLGWRISDVSIRNGLEQTFLVGRSHFLSAEEAEILGLPGATILLDGA

Query:  HTKDSAKALVDTIQMTFPEARLALVVAMASDKDHIGFAREFLKGGKLESIVLTEANIGGAKSRTTSAALLRDCWIQASNELGISVSLETKDASVSSMSKL
        HTKDSAKALVDTIQM+FP+A+LALVVAMASDKDH GFA EFL+GGKLESIVL+EANIGG+KSRTTSAALLRDCWIQASNE+GI +SLETKDA VSS SKL
Subjt:  HTKDSAKALVDTIQMTFPEARLALVVAMASDKDHIGFAREFLKGGKLESIVLTEANIGGAKSRTTSAALLRDCWIQASNELGISVSLETKDASVSSMSKL

Query:  ENRPILTTETSLLHAIKITVENLKQRTEGQQRGLIVVTGSLNAISMVLSSIHS
        ENRP+LTTETSLL AIKI  E LKQR +G +RGL+VVTGSL+A+SMVLSS+HS
Subjt:  ENRPILTTETSLLHAIKITVENLKQRTEGQQRGLIVVTGSLNAISMVLSSIHS

XP_023553540.1 dihydrofolate synthetase [Cucurbita pepo subsp. pepo]

2.7e-252

83.73

Show/hide

Query:  FKHHHHCPPQILGRLLLNYFAGERPSISRRIGSKQCFDTHSEDQEITEFMEYLDSLKNYEKLGVPRGAGTDSDDGFDLGRMRRMMERLGNPQSKFKTNGR
        FK+HHH  PQI GRLLLNYF GE PSIS RIGSKQCF  HSEDQ++TEFMEYLDSLKNYEKLGVP GAGTDS+DGFDLGRM+R+MERLGNPQSKFK    
Subjt:  FKHHHHCPPQILGRLLLNYFAGERPSISRRIGSKQCFDTHSEDQEITEFMEYLDSLKNYEKLGVPRGAGTDSDDGFDLGRMRRMMERLGNPQSKFKTNGR

Query:  IIIGHSHCGNQGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISLERSGEMVSGKALNSLFKRNKEFLDQSVELENGHISHFEVLTAMAFSLFAQEK
        I I     G +GKGSTAAFLS+ILRAEGYSVGCYTSPHIETIRERISL RSGEMVSGKALN LFKRNKE LDQSV+LENG ISHFEVLTAMAFSLFAQE 
Subjt:  IIIGHSHCGNQGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISLERSGEMVSGKALNSLFKRNKEFLDQSVELENGHISHFEVLTAMAFSLFAQEK

Query:  VDVAVIEAGLGGARDATNIICSSRLAAAVITSIGEEYVAVLGGSLESIATAKAGIIKHGCPTILAGPFLPSIECILRDKALSMSSSVLSASDPGNKSTIK
        VDVAVIEAGLGGARDATNIICSSRLAAAVITSIGEE++A LGGSLESIA AKAGIIKHGCPTIL GPF+P+IECILRDKALSMSS V+SASDPGN+STIK
Subjt:  VDVAVIEAGLGGARDATNIICSSRLAAAVITSIGEEYVAVLGGSLESIATAKAGIIKHGCPTILAGPFLPSIECILRDKALSMSSSVLSASDPGNKSTIK

Query:  GVNLLNGRLCQCCDIVIQIDNE--SYWMSTSRMLGSHQLQNAATATCVILTLRNLGWRISDVSIRNGLEQTFLVGRSHFLSAEEAEILGLPGATILLDGA
        GV+LLNGRLCQCCD++IQ DNE    +    RMLG HQLQNAATATCVILTLRNLGWRISD SIR+GLE+TFLVGRSHFLSA+EA +LGLPG TILLDGA
Subjt:  GVNLLNGRLCQCCDIVIQIDNE--SYWMSTSRMLGSHQLQNAATATCVILTLRNLGWRISDVSIRNGLEQTFLVGRSHFLSAEEAEILGLPGATILLDGA

Query:  HTKDSAKALVDTIQMTFPEARLALVVAMASDKDHIGFAREFLKGGKLESIVLTEANIGGAKSRTTSAALLRDCWIQASNELGISVSLETKDASVSSMSKL
        HTKDSAKALVDTIQM+FP+A+LALVVAMASDKDH GFA EFL+GGKLESIVL+EANIGG KSRTTSAALLRDCWIQASNE+GI +SLETKDA VSS SKL
Subjt:  HTKDSAKALVDTIQMTFPEARLALVVAMASDKDHIGFAREFLKGGKLESIVLTEANIGGAKSRTTSAALLRDCWIQASNELGISVSLETKDASVSSMSKL

Query:  ENRPILTTETSLLHAIKITVENLKQRTEGQQRGLIVVTGSLNAISMVLSSIHS
        ENRP+LTTETSLL AIKI  E LKQR EG +RGL+VVTGSL+A+SMVLSS+HS
Subjt:  ENRPILTTETSLLHAIKITVENLKQRTEGQQRGLIVVTGSLNAISMVLSSIHS

XP_038905573.1 dihydrofolate synthetase [Benincasa hispida]

3.0e-251

83.73

Show/hide

Query:  FKHHHHCPPQILGRLLLNYFAGERPSISRRIGSKQCFDTHSEDQEITEFMEYLDSLKNYEKLGVPRGAGTDSDDGFDLGRMRRMMERLGNPQSKFKTNGR
        FK+HHHC PQILG LLLN+F GE PSIS RIGSKQCF TH EDQ +TEFMEYLDSLKNYEKLGVP+GAGTDSDDGFDLGRMRR+MERLGNPQSKFK    
Subjt:  FKHHHHCPPQILGRLLLNYFAGERPSISRRIGSKQCFDTHSEDQEITEFMEYLDSLKNYEKLGVPRGAGTDSDDGFDLGRMRRMMERLGNPQSKFKTNGR

Query:  IIIGHSHCGNQGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISLERSGEMVSGKALNSLFKRNKEFLDQSVELENGHISHFEVLTAMAFSLFAQEK
        I I     G +GKGSTAAFLSNILRAEGYS GCYTSPHIETIRERISL RSGEMVSGKALNSLFKRNKEF DQSVELENG ISHFEVLTAMAF LFAQE 
Subjt:  IIIGHSHCGNQGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISLERSGEMVSGKALNSLFKRNKEFLDQSVELENGHISHFEVLTAMAFSLFAQEK

Query:  VDVAVIEAGLGGARDATNIICSSRLAAAVITSIGEEYVAVLGGSLESIATAKAGIIKHGCPTILAGPFLPSIECILRDKALSMSSSVLSASDPGNKSTIK
        VD+AVIEAGLGGARDATNIICSS LAAAVITSIGEE++A LGGSLESIATAKAGIIK GCP IL GPFLPSIE ILRDKALSMSS V+SAS PGN+STIK
Subjt:  VDVAVIEAGLGGARDATNIICSSRLAAAVITSIGEEYVAVLGGSLESIATAKAGIIKHGCPTILAGPFLPSIECILRDKALSMSSSVLSASDPGNKSTIK

Query:  GVNLLNGRLCQCCDIVIQIDNESYWM--STSRMLGSHQLQNAATATCVILTLRNLGWRISDVSIRNGLEQTFLVGRSHFLSAEEAEILGLPGATILLDGA
        GV+LLNG +CQCCD+VIQID+E   +     RMLG HQLQNAATATCVIL LRNLGWRISD S+R+GLEQTFLVGRSHFL A+EA +LGLPGATILLDGA
Subjt:  GVNLLNGRLCQCCDIVIQIDNESYWM--STSRMLGSHQLQNAATATCVILTLRNLGWRISDVSIRNGLEQTFLVGRSHFLSAEEAEILGLPGATILLDGA

Query:  HTKDSAKALVDTIQMTFPEARLALVVAMASDKDHIGFAREFLKGGKLESIVLTEANIGGAKSRTTSAALLRDCWIQASNELGISVSLETKDASVSSMSKL
        HTKDSAKALVDTIQM FPEARLALVVAMASDKDHIGFAREFL+GGKLESIVLTEA+IGG KSRTTSA  LRDCWIQASNELGI +SLETKDA VS  SKL
Subjt:  HTKDSAKALVDTIQMTFPEARLALVVAMASDKDHIGFAREFLKGGKLESIVLTEANIGGAKSRTTSAALLRDCWIQASNELGISVSLETKDASVSSMSKL

Query:  ENRPILTTETSLLHAIKITVENLKQRTEGQQRGLIVVTGSLNAISMVLSSIHS
        ENRP+LTTETSLLHAIK+  E LKQRTEG+Q GL+VVTGSL+A+SMVLS +HS
Subjt:  ENRPILTTETSLLHAIKITVENLKQRTEGQQRGLIVVTGSLNAISMVLSSIHS

TrEMBL top hits

e value

%identity

Alignment

A0A0A0L7A4 Mur_ligase_M domain-containing protein

1.9e-251

83.36

Show/hide

Query:  FKHHHHCPPQILGRLLLNYFAGERPSISRRIGSKQCFDTHSEDQEITEFMEYLDSLKNYEKLGVPRGAGTDSDDGFDLGRMRRMMERLGNPQSKFKTNGR
        FK+HHHC PQILG LLLN+F GE PSIS R GSKQCF THSEDQ +T+FMEYLDSLKNYEKLGVPRG+GTDSDDGFDLGRMRR+MERLGNPQS+FK    
Subjt:  FKHHHHCPPQILGRLLLNYFAGERPSISRRIGSKQCFDTHSEDQEITEFMEYLDSLKNYEKLGVPRGAGTDSDDGFDLGRMRRMMERLGNPQSKFKTNGR

Query:  IIIGHSHCGNQGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISLERSGEMVSGKALNSLFKRNKEFLDQSVELENGHISHFEVLTAMAFSLFAQEK
        I I     G +GKGSTAAFLSNILR EGYSVGCYTSPHIETIRERISL RSG+MVSGKALNSLFKRNKE  DQSVELENGH+SHFEVLTAMAFSLFAQE 
Subjt:  IIIGHSHCGNQGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISLERSGEMVSGKALNSLFKRNKEFLDQSVELENGHISHFEVLTAMAFSLFAQEK

Query:  VDVAVIEAGLGGARDATNIICSSRLAAAVITSIGEEYVAVLGGSLESIATAKAGIIKHGCPTILAGPFLPSIECILRDKALSMSSSVLSASDPGNKSTIK
        VDVAVIEAGLGGARDATNIICSS LAAAVITSIGEE+VA LGGSLESIATAKAGIIK GCPTIL GPFLP IE ILRDKALSMSS V+SASDPGN+STIK
Subjt:  VDVAVIEAGLGGARDATNIICSSRLAAAVITSIGEEYVAVLGGSLESIATAKAGIIKHGCPTILAGPFLPSIECILRDKALSMSSSVLSASDPGNKSTIK

Query:  GVNLLNGRLCQCCDIVIQIDNESYWM--STSRMLGSHQLQNAATATCVILTLRNLGWRISDVSIRNGLEQTFLVGRSHFLSAEEAEILGLPGATILLDGA
        GVNLLNG L QCCDIVIQIDNE   +     RMLG HQLQNAATATCVILTLRNLGWRISD SIR+GLEQTFL+GRSHFL+A EAE+LGLPGATILLDGA
Subjt:  GVNLLNGRLCQCCDIVIQIDNESYWM--STSRMLGSHQLQNAATATCVILTLRNLGWRISDVSIRNGLEQTFLVGRSHFLSAEEAEILGLPGATILLDGA

Query:  HTKDSAKALVDTIQMTFPEARLALVVAMASDKDHIGFAREFLKGGKLESIVLTEANIGGAKSRTTSAALLRDCWIQASNELGISVSLETKDASVSSMSKL
        HTKDSAKAL+DTIQM FPEA+LALVVAMASDK+H+GFAREFL+GGKLES+VLTEA IGG KSRTTSAA LRDCWIQASNELGI +SLETKDA V   SKL
Subjt:  HTKDSAKALVDTIQMTFPEARLALVVAMASDKDHIGFAREFLKGGKLESIVLTEANIGGAKSRTTSAALLRDCWIQASNELGISVSLETKDASVSSMSKL

Query:  ENRPILTTETSLLHAIKITVENLKQRTEGQQRGLIVVTGSLNAISMVLSSIHS
         NRP+LTTETSLLHAIKI  E LKQRT+G+Q GL+VV+GSL+A+SMVL+S+HS
Subjt:  ENRPILTTETSLLHAIKITVENLKQRTEGQQRGLIVVTGSLNAISMVLSSIHS

A0A1S3CNR7 dihydrofolate synthetase isoform X1

3.0e-249

Show/hide

Query:  FKHHHHCPPQILGRLLLNYFAGERPSISRRIGSKQCFDTHSEDQEITEFMEYLDSLKNYEKLGVPRGAGTDSDDGFDLGRMRRMMERLGNPQSKFKTNGR
        FK+HHHC PQILG LLLN+F GE PSIS R GSKQCF THSEDQ +TEFMEYLDSLKNYEKLGVPRGAGTDSDDGFDLGRMRR+MERLGNPQSKFK    
Subjt:  FKHHHHCPPQILGRLLLNYFAGERPSISRRIGSKQCFDTHSEDQEITEFMEYLDSLKNYEKLGVPRGAGTDSDDGFDLGRMRRMMERLGNPQSKFKTNGR

Query:  IIIGHSHCGNQGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISLERSGEMVSGKALNSLFKRNKEFLDQSVELENGHISHFEVLTAMAFSLFAQEK
        I I     G +GKGS AAFLSNILRAEGYSVGCYTSPHIET+RERISL RSGEMVSGKALNSLFKRNKE  DQSVELE+G ISHFEVLTAMAFSLFAQE 
Subjt:  IIIGHSHCGNQGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISLERSGEMVSGKALNSLFKRNKEFLDQSVELENGHISHFEVLTAMAFSLFAQEK

Query:  VDVAVIEAGLGGARDATNIICSSRLAAAVITSIGEEYVAVLGGSLESIATAKAGIIKHGCPTILAGPFLPSIECILRDKALSMSSSVLSASDPGNKSTIK
        VDVAVIEAGLGGARDATNIICSS LAAAVITSIGEE++A LGGSLESIA AKAGIIK GCPTIL G FLP IE ILRDKALSMSS V++ SDPGN+STIK
Subjt:  VDVAVIEAGLGGARDATNIICSSRLAAAVITSIGEEYVAVLGGSLESIATAKAGIIKHGCPTILAGPFLPSIECILRDKALSMSSSVLSASDPGNKSTIK

Query:  GVNLLNGRLCQCCDIVIQIDNESYWM--STSRMLGSHQLQNAATATCVILTLRNLGWRISDVSIRNGLEQTFLVGRSHFLSAEEAEILGLPGATILLDGA
        GVN+LNG LCQCCDIVIQIDNE   +     RMLG HQLQNAATATCVILTLRNLGWRISD SIR+GLEQTFL+GRSHFL+A+EAE+LGLPGATILLDGA
Subjt:  GVNLLNGRLCQCCDIVIQIDNESYWM--STSRMLGSHQLQNAATATCVILTLRNLGWRISDVSIRNGLEQTFLVGRSHFLSAEEAEILGLPGATILLDGA

Query:  HTKDSAKALVDTIQMTFPEARLALVVAMASDKDHIGFAREFLKGGKLESIVLTEANIGGAKSRTTSAALLRDCWIQASNELGISVSLETKDASVSSMSKL
        HTKDSAKALVDTIQM FPEARLALV+AMASDK+H+ FAREFL+GGKLE +VLTEA+IGG KSRTTSAA LRDCWIQAS ELGI +SLETKDA VS  SKL
Subjt:  HTKDSAKALVDTIQMTFPEARLALVVAMASDKDHIGFAREFLKGGKLESIVLTEANIGGAKSRTTSAALLRDCWIQASNELGISVSLETKDASVSSMSKL

Query:  ENRPILTTETSLLHAIKITVENLKQRTEGQQRGLIVVTGSLNAISMVLSSIHS
        ENRP+LTTETSLLHAIKI  E LKQRT+GQQ  L+VV+GSL+A+SMVLSS+HS
Subjt:  ENRPILTTETSLLHAIKITVENLKQRTEGQQRGLIVVTGSLNAISMVLSSIHS

A0A6J1CJG1 dihydrofolate synthetase isoform X1

9.0e-254

84.99

Show/hide

Query:  FKHHHHCPPQILGRLLLNYFAGERPSISRRIGSKQCFDTHSEDQEITEFMEYLDSLKNYEKLGVPRGAGTDSDDGFDLGRMRRMMERLGNPQSKFKTNGR
        FK+H    PQILG LLLN+  GE PSIS RIGSKQCF THSED E+TEFMEYLDSLKNYEKLGVPRGAGTDSDDGFDLGRMRR+MERLGNPQSKFK    
Subjt:  FKHHHHCPPQILGRLLLNYFAGERPSISRRIGSKQCFDTHSEDQEITEFMEYLDSLKNYEKLGVPRGAGTDSDDGFDLGRMRRMMERLGNPQSKFKTNGR

Query:  IIIGHSHCGNQGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISLERSGEMVSGKALNSLFKRNKEFLDQSVELENGHISHFEVLTAMAFSLFAQEK
        I I     G +GKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISL RSGEMVSGKALNSLFKRNKEFLDQSVE ENG ISHFEVLTAMAFSLFAQE 
Subjt:  IIIGHSHCGNQGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISLERSGEMVSGKALNSLFKRNKEFLDQSVELENGHISHFEVLTAMAFSLFAQEK

Query:  VDVAVIEAGLGGARDATNIICSSRLAAAVITSIGEEYVAVLGGSLESIATAKAGIIKHGCPTILAGPFLPSIECILRDKALSMSSSVLSASDPGNKSTIK
        VDVAVIEAGLGGARDATNIICSSRLAAAVITSIGEE++A LGGSLESIA AKAGIIKHGCPTIL GPFLPSIECIL DKALSMSS V+SAS PG++STIK
Subjt:  VDVAVIEAGLGGARDATNIICSSRLAAAVITSIGEEYVAVLGGSLESIATAKAGIIKHGCPTILAGPFLPSIECILRDKALSMSSSVLSASDPGNKSTIK

Query:  GVNLLNGRLCQCCDIVIQIDNESYWM--STSRMLGSHQLQNAATATCVILTLRNLGWRISDVSIRNGLEQTFLVGRSHFLSAEEAEILGLPGATILLDGA
        GV+LL+GRLCQCCDIVIQIDNE   +     RMLG HQLQNAATATC ILTLRNLGWRISD SI+ GLEQTFLVGRSHFLSA+EA +LGLPGATILLDGA
Subjt:  GVNLLNGRLCQCCDIVIQIDNESYWM--STSRMLGSHQLQNAATATCVILTLRNLGWRISDVSIRNGLEQTFLVGRSHFLSAEEAEILGLPGATILLDGA

Query:  HTKDSAKALVDTIQMTFPEARLALVVAMASDKDHIGFAREFLKGGKLESIVLTEANIGGAKSRTTSAALLRDCWIQASNELGISVSLETKDASVSSMSKL
        HTKDSAKALVDTIQMTFPEARLALVVAMASDKDH+GFAREFL+GGKLESI+LTEANIGG KSRTTSAA+LRDCWIQA+NELGI +SLETKDA VSS SKL
Subjt:  HTKDSAKALVDTIQMTFPEARLALVVAMASDKDHIGFAREFLKGGKLESIVLTEANIGGAKSRTTSAALLRDCWIQASNELGISVSLETKDASVSSMSKL

Query:  ENRPILTTETSLLHAIKITVENLKQRTEGQQRGLIVVTGSLNAISMVLSSIHS
        E+RPILTTETSLLHA+KI  E LKQRTEG + GL VVTGSL+A+SMVLSS+HS
Subjt:  ENRPILTTETSLLHAIKITVENLKQRTEGQQRGLIVVTGSLNAISMVLSSIHS

A0A6J1E819 dihydrofolate synthetase isoform X1

6.5e-252

83.36

Show/hide

Query:  FKHHHHCPPQILGRLLLNYFAGERPSISRRIGSKQCFDTHSEDQEITEFMEYLDSLKNYEKLGVPRGAGTDSDDGFDLGRMRRMMERLGNPQSKFKTNGR
        FK+HHH  PQI GRLLLNYF GE PSIS RIGSKQCF  HSEDQ++TEFMEYLDSLKNYEKLGVP GAGTDS+DGFDLGRM+R+MERLGNPQSKFK    
Subjt:  FKHHHHCPPQILGRLLLNYFAGERPSISRRIGSKQCFDTHSEDQEITEFMEYLDSLKNYEKLGVPRGAGTDSDDGFDLGRMRRMMERLGNPQSKFKTNGR

Query:  IIIGHSHCGNQGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISLERSGEMVSGKALNSLFKRNKEFLDQSVELENGHISHFEVLTAMAFSLFAQEK
        I I     G +GKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISL RSGEMVSGKALN LFKRNKE LDQSV+LENG ISHFEVLTAMAFSLFAQE 
Subjt:  IIIGHSHCGNQGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISLERSGEMVSGKALNSLFKRNKEFLDQSVELENGHISHFEVLTAMAFSLFAQEK

Query:  VDVAVIEAGLGGARDATNIICSSRLAAAVITSIGEEYVAVLGGSLESIATAKAGIIKHGCPTILAGPFLPSIECILRDKALSMSSSVLSASDPGNKSTIK
        VDVAVIEAGLGGARDATNIICSSRLAAAVITSIGEE++A LGGSLESIA AKAGIIKHGCPTIL GPF+P+IECILRDKALSMSS V+SASDPGN+S+IK
Subjt:  VDVAVIEAGLGGARDATNIICSSRLAAAVITSIGEEYVAVLGGSLESIATAKAGIIKHGCPTILAGPFLPSIECILRDKALSMSSSVLSASDPGNKSTIK

Query:  GVNLLNGRLCQCCDIVIQIDNE--SYWMSTSRMLGSHQLQNAATATCVILTLRNLGWRISDVSIRNGLEQTFLVGRSHFLSAEEAEILGLPGATILLDGA
        GV+LLNGRLCQCCD++IQ DNE    +    RMLG HQLQNAATATCVILTLRNLGWRIS+ SIR+GLE+TFLVGRSHFLSA+EA ILGLPG  ILLDGA
Subjt:  GVNLLNGRLCQCCDIVIQIDNE--SYWMSTSRMLGSHQLQNAATATCVILTLRNLGWRISDVSIRNGLEQTFLVGRSHFLSAEEAEILGLPGATILLDGA

Query:  HTKDSAKALVDTIQMTFPEARLALVVAMASDKDHIGFAREFLKGGKLESIVLTEANIGGAKSRTTSAALLRDCWIQASNELGISVSLETKDASVSSMSKL
        HTKDSAKALVDTIQM+FP+A+LALVVAMASDKDH GFA EFL+GGKLESIVL+EANIGG+KSRTTSAALLRDCWIQASNE+GI +SLETKDA VSS SKL
Subjt:  HTKDSAKALVDTIQMTFPEARLALVVAMASDKDHIGFAREFLKGGKLESIVLTEANIGGAKSRTTSAALLRDCWIQASNELGISVSLETKDASVSSMSKL

Query:  ENRPILTTETSLLHAIKITVENLKQRTEGQQRGLIVVTGSLNAISMVLSSIHS
        ENRP+LTTETSLL AIKI  E LKQR +G +RGL+VVTGSL+A+SMVLSS+HS
Subjt:  ENRPILTTETSLLHAIKITVENLKQRTEGQQRGLIVVTGSLNAISMVLSSIHS

A0A6J1J6Z7 dihydrofolate synthetase isoform X1

2.4e-238

80.47

Show/hide

Query:  FKHHHHCPPQILGRLLLNYFAGERPSISRRIGSKQCFDTHSEDQEITEFMEYLDSLKNYEKLGVPRGAGTDSDDGFDLGRMRRMMERLGNPQSKFKTNGR
        FK+HHH   QILGRLLLNYF GE PSIS RIGSKQCF  HSEDQ++TEFMEYLDSLKNYEKLGVP GAGTDS+DGFDLGRM+R+MERLGNPQSKFK    
Subjt:  FKHHHHCPPQILGRLLLNYFAGERPSISRRIGSKQCFDTHSEDQEITEFMEYLDSLKNYEKLGVPRGAGTDSDDGFDLGRMRRMMERLGNPQSKFKTNGR

Query:  IIIGHSHCGNQGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISLERSGEMVSGKALNSLFKRNKEFLDQSVELENGHISHFEVLTAMAFSLFAQEK
        I I     G +GKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISL RSGEMVSGKALN LFKRNKE LDQSV+LENG ISHFEVLTAMAFSLFAQE 
Subjt:  IIIGHSHCGNQGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISLERSGEMVSGKALNSLFKRNKEFLDQSVELENGHISHFEVLTAMAFSLFAQEK

Query:  VDVAVIEAGLGGARDATNIICSSRLAAAVITSIGEEYVAVLGGSLESIATAKAGIIKHGCPTILAGPFLPSIECILRDKALSMSSSVLSASDPGNKSTIK
        VDVAVIEAGLGGARDATNIICSS LAAAVITSIGEE++A LGGSLESIA AKAGIIKHGCPTIL GPF+P+IECILRDKALSMSS V+SASDPGN+STIK
Subjt:  VDVAVIEAGLGGARDATNIICSSRLAAAVITSIGEEYVAVLGGSLESIATAKAGIIKHGCPTILAGPFLPSIECILRDKALSMSSSVLSASDPGNKSTIK

Query:  GVNLLNGRLCQCCDIVIQIDNE--SYWMSTSRMLGSHQLQNAATATCVILTLRNLGWRISDVSIRNGLEQTFLVGRSHFLSAEEAEILGLPGATILLDGA
        GV+LLNGRLCQCCD++IQ D+E    +    RMLG HQLQNAATATCVILTLRNLGWRISD SIR+GLE+TFLVGRSHFLSA+EA +LGLPG TILLDGA
Subjt:  GVNLLNGRLCQCCDIVIQIDNE--SYWMSTSRMLGSHQLQNAATATCVILTLRNLGWRISDVSIRNGLEQTFLVGRSHFLSAEEAEILGLPGATILLDGA

Query:  HTKDSAKALVDTIQMTFPEARLALVVAMASDKDHIGFAREFLKGGKLESIVLTEANIGGAKSRTTSAALLRDCWIQASNELGISVSLETKDASVSSMSKL
        HTKDSAKALVDTIQM+FP+A+LALVVAMASDKDH GFA EFL+ GKLESIVL+EANIGG KSRTTSAALLRDCWIQASNE+GI                 
Subjt:  HTKDSAKALVDTIQMTFPEARLALVVAMASDKDHIGFAREFLKGGKLESIVLTEANIGGAKSRTTSAALLRDCWIQASNELGISVSLETKDASVSSMSKL

Query:  ENRPILTTETSLLHAIKITVENLKQRTEGQQRGLIVVTGSLNAISMVLSSIHS
            +LTTETSLL AIKI  E LKQRTEG +RGL+VVTGSL+A+SMVLSS+HS
Subjt:  ENRPILTTETSLLHAIKITVENLKQRTEGQQRGLIVVTGSLNAISMVLSSIHS

SwissProt top hits

e value

%identity

Alignment

D4GW05 Probable bifunctional folylpolyglutamate synthase/dihydropteroate synthase

1.8e-25

29.75

Show/hide

Query:  MRRMMERLGNPQSKFKTNGRIIIGHSHCGNQGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISLERSGEMVSGKALNSLFKRNKEFLDQSVELENG
        +RR++  LG+P          +      G+ GKGSTA  +  +LR  G  VG YTSPH + +RER+ ++  G  +   AL++     K +L +    +  
Subjt:  MRRMMERLGNPQSKFKTNGRIIIGHSHCGNQGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISLERSGEMVSGKALNSLFKRNKEFLDQSVELENG

Query:  HISHFEVLTAMAFSLFAQEKVDVAVIEAGLGGARDATNIICSSRLAAAVITSIGEEYVAVLGGSLESIATAKAGIIKHGCPTILAGPFLPSIECILRDKA
         ++ FE +TA+A   F +  VDVAV+E G+GG  DAT+ +      A+ +T++  E+ AVLG ++  IA  KA +     P ++ G    ++  ++R++A
Subjt:  HISHFEVLTAMAFSLFAQEKVDVAVIEAGLGGARDATNIICSSRLAAAVITSIGEEYVAVLGGSLESIATAKAGIIKHGCPTILAGPFLPSIECILRDKA

Query:  LSMSSSVLSASDPGNKSTIKGVNLLNGRL-CQCCDIVIQIDNESYWMSTSRMLGSHQLQNAATATCVILTLRNLGWRISDVSIRNGLEQTFLVGRSHFLS
              VL+  D    S         GR+  Q   + ++ D E+  +    +LG++Q +NA  A  +   +R     I   +I  GL      GR   + 
Subjt:  LSMSSSVLSASDPGNKSTIKGVNLLNGRL-CQCCDIVIQIDNESYWMSTSRMLGSHQLQNAATATCVILTLRNLGWRISDVSIRNGLEQTFLVGRSHFLS

Query:  AEEAEILGLPGATILLDGAHTKDSAKALVDTIQMTFPEARLALVVAMASDKDH
         E          T++LDGAH  D A A V T+   F    L LV     DKDH
Subjt:  AEEAEILGLPGATILLDGAHTKDSAKALVDTIQMTFPEARLALVVAMASDKDH

F4JYE9 Dihydrofolate synthetase

9.3e-147

56.98

Show/hide

Query:  SEDQEITEFMEYLDSLKNYEKLGVPRGAGTDSDDGFDLGRMRRMMERLGNPQSKFKTNGRIIIGHSHCGNQGKGSTAAFLSNILRAEGYSVGCYTSPHIE
        +ED E+ +F+ +L+SLKNYEK GVP+GAGTDSDDGFDLGRM+R+M RL NP  K+K      + H   G +GKGST+AFLSNILRA GYSVGCY+SPHI 
Subjt:  SEDQEITEFMEYLDSLKNYEKLGVPRGAGTDSDDGFDLGRMRRMMERLGNPQSKFKTNGRIIIGHSHCGNQGKGSTAAFLSNILRAEGYSVGCYTSPHIE

Query:  TIRERISLERSGEMVSGKALNSLFKRNKEFLDQSVELENGHISHFEVLTAMAFSLFAQEKVDVAVIEAGLGGARDATNIICSSRLAAAVITSIGEEYVAV
        +I+ERIS   +GE VS   LN LF   K  L+QS++ ENG +SHFE+LT +AFSLF +E VD+AVIEAGLGGARDATN+I SS LAA+VIT+IGEE++A 
Subjt:  TIRERISLERSGEMVSGKALNSLFKRNKEFLDQSVELENGHISHFEVLTAMAFSLFAQEKVDVAVIEAGLGGARDATNIICSSRLAAAVITSIGEEYVAV

Query:  LGGSLESIATAKAGIIKHGCPTILAGPFLPSIECILRDKALSMSSSVLSASDPGNKSTIKGVNLLNG-RLCQCCDIVIQIDNESYWM-----STSRMLGS
        LGGSLESIA AK+GIIKHG P +L GPFLP IE ILR KA S+SSSV+ AS+ G+ S+IKG+   NG  LCQ CDIVIQ + +   +        RMLG 
Subjt:  LGGSLESIATAKAGIIKHGCPTILAGPFLPSIECILRDKALSMSSSVLSASDPGNKSTIKGVNLLNG-RLCQCCDIVIQIDNESYWM-----STSRMLGS

Query:  HQLQNAATATCVILTLRNLG-WRISDVSIRNGLEQTFLVGRSHFLSAEEAEILGLPGATILLDGAHTKDSAKALVDTIQMTFPEARLALVVAMASDKDHI
        HQLQNA TATCV L LR+ G  R++D +IR GLE T L+GRS FL+ +EAE L LPGAT+LLDGAHTK+SA+AL + I+  FPE RL  VVAMASDKDH+
Subjt:  HQLQNAATATCVILTLRNLG-WRISDVSIRNGLEQTFLVGRSHFLSAEEAEILGLPGATILLDGAHTKDSAKALVDTIQMTFPEARLALVVAMASDKDHI

Query:  GFAREFLKGGKLESIVLTEANIGGAKSRTTSAALLRDCWIQASNELGISVSLETKDASVSSMSKLENRPILTTETSLLHAIKITVENLKQRTEGQQRGLI
         FA+E L G K E+++LTEA+IGG K R+T +++L++ WI+A++ELG             SM   EN+       ++L ++K+  + L   T     G++
Subjt:  GFAREFLKGGKLESIVLTEANIGGAKSRTTSAALLRDCWIQASNELGISVSLETKDASVSSMSKLENRPILTTETSLLHAIKITVENLKQRTEGQQRGLI

Query:  VVTGSLNAISMVLSSI
        +VTGSL+ +S VL+S+
Subjt:  VVTGSLNAISMVLSSI

P43775 Dihydrofolate synthase/folylpolyglutamate synthase

6.9e-25

30.15

Show/hide

Query:  GNQGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISLERSGEMVSGKALNSLFKRNKEFLDQSVELENGHISHFEVLTAMAFSLFAQEKVDVAVIEA
        G  GKG+T   L  IL   G  VG Y+SPH+    ER+ ++   + +  +A  + F     F+D++   +   +++FE  T  A  LF Q K+DV ++E 
Subjt:  GNQGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISLERSGEMVSGKALNSLFKRNKEFLDQSVELENGHISHFEVLTAMAFSLFAQEKVDVAVIEA

Query:  GLGGARDATNIICSSRLAAAVITSIGEEYVAVLGGSLESIATAKAGIIKHGCPTILAGPFLPSIECILRDKALSMSSSVLSASDPGNKSTIKGVNLLNGR
        GLGG  DATNI+ S     AVITSI  ++   LG + E+IA  KAGI +  CP ++  P +P     + D+A  +   V        +  +  +   N  
Subjt:  GLGGARDATNIICSSRLAAAVITSIGEEYVAVLGGSLESIATAKAGIIKHGCPTILAGPFLPSIECILRDKALSMSSSVLSASDPGNKSTIKGVNLLNGR

Query:  LCQCCDIVIQIDNESYWMSTSRMLGSHQLQNAATATCVILTLRNLGWRISDVSIRNGLEQTFLVGRSHFLSAEE----AEILGLPG---ATILLDGAHTK
          Q  +  ++++N  +            L NAAT   V+  ++ L + IS+ ++R  L++  LVGR   +  ++    A+ LG+P     TI++D  H  
Subjt:  LCQCCDIVIQIDNESYWMSTSRMLGSHQLQNAATATCVILTLRNLGWRISDVSIRNGLEQTFLVGRSHFLSAEE----AEILGLPG---ATILLDGAHTK

Query:  DSAKALVD--TIQMTFPEARLALVVAMASDKDHIG
         +AK L +  T      E ++  V  M  DKD  G
Subjt:  DSAKALVD--TIQMTFPEARLALVVAMASDKDHIG

Q05865 Dihydrofolate synthase/folylpolyglutamate synthase

6.0e-37

31.48

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Query:  LGRMRRMMERLGNPQSKFKTNGRIIIGHSHCGNQGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISLERSGEMVSGKALNSLFKRNKEFLDQSVEL
        LGRM+++M RLG+P+ K +            G  GKGST AF+ ++L+  GY+VG +TSP+I T  ERIS+  +G  +S +   +L  + K  ++   + 
Subjt:  LGRMRRMMERLGNPQSKFKTNGRIIIGHSHCGNQGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISLERSGEMVSGKALNSLFKRNKEFLDQSVEL

Query:  ENGHISHFEVLTAMAFSLFAQ-EKVDVAVIEAGLGGARDATNIICSSRLAAAVITSIGEEYVAVLGGSLESIATAKAGIIKHGCPTILAGPFLPSIECIL
        E G  + FE++TA AF  FA+  KVD  + E GLGG  D+TN++        VITSIG +++ +LG ++E IA  KAGIIK G P I+     P    ++
Subjt:  ENGHISHFEVLTAMAFSLFAQ-EKVDVAVIEAGLGGARDATNIICSSRLAAAVITSIGEEYVAVLGGSLESIATAKAGIIKHGCPTILAGPFLPSIECIL

Query:  RDKALSMSSSVLSASDPGNKSTIKGVNLLNGRLCQCCD-IVIQIDNESYWMSTSRMLGSHQLQNAATATCVI--LTLRNLGWRISDVSIRNGLEQTFLVG
        R +A   ++   S  D           + N       +    + + + Y    + ++G+HQ QNAA +      L   N+   ISD ++R+GL +    G
Subjt:  RDKALSMSSSVLSASDPGNKSTIKGVNLLNGRLCQCCD-IVIQIDNESYWMSTSRMLGSHQLQNAATATCVI--LTLRNLGWRISDVSIRNGLEQTFLVG

Query:  RSHFLSAEEAEILGLPGATILLDGAHTKDSAKALVDTIQMTFPEARLALVVAMASDKDH
        R   +              + LDGAH ++  + L +T++  F  +R+++V +   DK +
Subjt:  RSHFLSAEEAEILGLPGATILLDGAHTKDSAKALVDTIQMTFPEARLALVVAMASDKDH

Q9HS44 Probable bifunctional folylpolyglutamate synthase/dihydropteroate synthase

1.5e-27

30.77

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Query:  GNQGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISLERSGEMVSGKALNSLFKRNKEFLDQSVELENGHISHFEVLTAMAFSLFAQEKVDVAVIEA
        G+ GKGSTA F  +ILRA G  VG YTSPH + +RER+++  +G  +S  AL +  +    ++ +    +    ++FEV+TAMA   F++  VDVAV+E 
Subjt:  GNQGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISLERSGEMVSGKALNSLFKRNKEFLDQSVELENGHISHFEVLTAMAFSLFAQEKVDVAVIEA

Query:  GLGGARDATNIICSSRLAAAVITSIGEEYVAVLGGSLESIATAKAGIIKHGCPTILAGPFLPSIECILRDKALSMSSSVLSASDPGNKSTIKGVNLLNGR
        G+GG  DAT+++  S   A+ +TS+  E+  VLG ++  IA  KA +   G   ++      ++  + RD A     +V +  D   +          GR
Subjt:  GLGGARDATNIICSSRLAAAVITSIGEEYVAVLGGSLESIATAKAGIIKHGCPTILAGPFLPSIECILRDKALSMSSSVLSASDPGNKSTIKGVNLLNGR

Query:  LCQCCDIVIQIDNESYWMSTS-RMLGSHQLQNAATATCVILTLRNLGWRISDVSIRNGLEQTFLVGRSHFLSAEEAEILGLPGATILLDGAHTKDSAKAL
             +  + I  + + ++T   +LG HQ +NA  A    L  +  G  + D +I  GL      GR   + A+           ++LDGAH   +  A+
Subjt:  LCQCCDIVIQIDNESYWMSTS-RMLGSHQLQNAATATCVILTLRNLGWRISDVSIRNGLEQTFLVGRSHFLSAEEAEILGLPGATILLDGAHTKDSAKAL

Query:  VDTIQMTFPEARLALVVAMASDKDH
         +T+   F   RL  V     DKDH
Subjt:  VDTIQMTFPEARLALVVAMASDKDH

Arabidopsis top hits

e value

%identity

Alignment

AT3G55630.2 DHFS-FPGS homolog D

3.4e-19

33.85

Show/hide

Query:  GNQGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISLERSGEMVSGKALNSLFKRNKEFLDQSVELENGHISHFEVLTAMAFSLFAQEKVDVAVIEA
        G +GKGST  F  +ILR  G   G +TSPH+  +RER  L  +G  +S +   + F      L +    E    ++F  L  +AF +F  E+VDV ++E 
Subjt:  GNQGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISLERSGEMVSGKALNSLFKRNKEFLDQSVELENGHISHFEVLTAMAFSLFAQEKVDVAVIEA

Query:  GLGGARDATNIICSSRLAAAVITSIGEEYVAVLGGSLESIATAKAGIIKHGCPTILAGPFLPSIECILRDKA--LSMSSSVLSASDPGNKSTIKG
        GLGG  DATNI    +     I+S+G +++ +LG +L  IA  KAGI K G P         ++  +L +KA  L ++  V+   D   +  ++G
Subjt:  GLGGARDATNIICSSRLAAAVITSIGEEYVAVLGGSLESIATAKAGIIKHGCPTILAGPFLPSIECILRDKA--LSMSSSVLSASDPGNKSTIKG

AT3G55630.3 DHFS-FPGS homolog D

1.5e-19

33.85

Show/hide

Query:  GNQGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISLERSGEMVSGKALNSLFKRNKEFLDQSVELENGHISHFEVLTAMAFSLFAQEKVDVAVIEA
        G +GKGST  F  +ILR  G   G +TSPH+  +RER  L  +G  +S +   + F      L +    E    ++F  L  +AF +F  E+VDV ++E 
Subjt:  GNQGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISLERSGEMVSGKALNSLFKRNKEFLDQSVELENGHISHFEVLTAMAFSLFAQEKVDVAVIEA

Query:  GLGGARDATNIICSSRLAAAVITSIGEEYVAVLGGSLESIATAKAGIIKHGCPTILAGPFLPSIECILRDKA--LSMSSSVLSASDPGNKSTIKG
        GLGG  DATN+I   +     I+S+G +++ +LG +L  IA  KAGI K G P         ++  +L +KA  L ++  V+   D   +  ++G
Subjt:  GLGGARDATNIICSSRLAAAVITSIGEEYVAVLGGSLESIATAKAGIIKHGCPTILAGPFLPSIECILRDKA--LSMSSSVLSASDPGNKSTIKG

AT5G05980.1 DHFS-FPGS homolog B

1.2e-19

37.58

Show/hide

Query:  GNQGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISLERSGEMVSGKALNSLF----KRNKEFLDQSVELENGHISHFEVLTAMAFSLFAQEKVDVA
        G +GKGST  F  +I+R  G+  G +TSPH+  +RER  L+  G  +S +     F     R KE  ++ + +     ++F  L  +AF +FA E+VD A
Subjt:  GNQGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISLERSGEMVSGKALNSLF----KRNKEFLDQSVELENGHISHFEVLTAMAFSLFAQEKVDVA

Query:  VIEAGLGGARDATNIICSSRLAAAVITSIGEEYVAVLGGSLESIATAKAGIIKHGCP
        ++E GLGG  DATN +   +     I+S+G +++ +LG +L  IA  KAGI K G P
Subjt:  VIEAGLGGARDATNIICSSRLAAAVITSIGEEYVAVLGGSLESIATAKAGIIKHGCP

AT5G05980.2 DHFS-FPGS homolog B

1.2e-19

37.58

Show/hide

Query:  GNQGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISLERSGEMVSGKALNSLF----KRNKEFLDQSVELENGHISHFEVLTAMAFSLFAQEKVDVA
        G +GKGST  F  +I+R  G+  G +TSPH+  +RER  L+  G  +S +     F     R KE  ++ + +     ++F  L  +AF +FA E+VD A
Subjt:  GNQGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISLERSGEMVSGKALNSLF----KRNKEFLDQSVELENGHISHFEVLTAMAFSLFAQEKVDVA

Query:  VIEAGLGGARDATNIICSSRLAAAVITSIGEEYVAVLGGSLESIATAKAGIIKHGCP
        ++E GLGG  DATN +   +     I+S+G +++ +LG +L  IA  KAGI K G P
Subjt:  VIEAGLGGARDATNIICSSRLAAAVITSIGEEYVAVLGGSLESIATAKAGIIKHGCP

AT5G41480.1 Folylpolyglutamate synthetase family protein

6.6e-148

56.98

Show/hide

Query:  SEDQEITEFMEYLDSLKNYEKLGVPRGAGTDSDDGFDLGRMRRMMERLGNPQSKFKTNGRIIIGHSHCGNQGKGSTAAFLSNILRAEGYSVGCYTSPHIE
        +ED E+ +F+ +L+SLKNYEK GVP+GAGTDSDDGFDLGRM+R+M RL NP  K+K      + H   G +GKGST+AFLSNILRA GYSVGCY+SPHI 
Subjt:  SEDQEITEFMEYLDSLKNYEKLGVPRGAGTDSDDGFDLGRMRRMMERLGNPQSKFKTNGRIIIGHSHCGNQGKGSTAAFLSNILRAEGYSVGCYTSPHIE

Query:  TIRERISLERSGEMVSGKALNSLFKRNKEFLDQSVELENGHISHFEVLTAMAFSLFAQEKVDVAVIEAGLGGARDATNIICSSRLAAAVITSIGEEYVAV
        +I+ERIS   +GE VS   LN LF   K  L+QS++ ENG +SHFE+LT +AFSLF +E VD+AVIEAGLGGARDATN+I SS LAA+VIT+IGEE++A 
Subjt:  TIRERISLERSGEMVSGKALNSLFKRNKEFLDQSVELENGHISHFEVLTAMAFSLFAQEKVDVAVIEAGLGGARDATNIICSSRLAAAVITSIGEEYVAV

Query:  LGGSLESIATAKAGIIKHGCPTILAGPFLPSIECILRDKALSMSSSVLSASDPGNKSTIKGVNLLNG-RLCQCCDIVIQIDNESYWM-----STSRMLGS
        LGGSLESIA AK+GIIKHG P +L GPFLP IE ILR KA S+SSSV+ AS+ G+ S+IKG+   NG  LCQ CDIVIQ + +   +        RMLG 
Subjt:  LGGSLESIATAKAGIIKHGCPTILAGPFLPSIECILRDKALSMSSSVLSASDPGNKSTIKGVNLLNG-RLCQCCDIVIQIDNESYWM-----STSRMLGS

Query:  HQLQNAATATCVILTLRNLG-WRISDVSIRNGLEQTFLVGRSHFLSAEEAEILGLPGATILLDGAHTKDSAKALVDTIQMTFPEARLALVVAMASDKDHI
        HQLQNA TATCV L LR+ G  R++D +IR GLE T L+GRS FL+ +EAE L LPGAT+LLDGAHTK+SA+AL + I+  FPE RL  VVAMASDKDH+
Subjt:  HQLQNAATATCVILTLRNLG-WRISDVSIRNGLEQTFLVGRSHFLSAEEAEILGLPGATILLDGAHTKDSAKALVDTIQMTFPEARLALVVAMASDKDHI

Query:  GFAREFLKGGKLESIVLTEANIGGAKSRTTSAALLRDCWIQASNELGISVSLETKDASVSSMSKLENRPILTTETSLLHAIKITVENLKQRTEGQQRGLI
         FA+E L G K E+++LTEA+IGG K R+T +++L++ WI+A++ELG             SM   EN+       ++L ++K+  + L   T     G++
Subjt:  GFAREFLKGGKLESIVLTEANIGGAKSRTTSAALLRDCWIQASNELGISVSLETKDASVSSMSKLENRPILTTETSLLHAIKITVENLKQRTEGQQRGLI

Query:  VVTGSLNAISMVLSSI
        +VTGSL+ +S VL+S+
Subjt:  VVTGSLNAISMVLSSI

Sequences

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CDS sequence

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ATGCTTGTGTATGGAGCTAAGGATTTGATTCTTACTGGATACACTGACTCTGACTTTCAAGCTGATAAGGATTCAAGGAAATCCACATCAGGGTCAGTATTCACCCTCAA
TGGAGGAGCAGTAGTTTGGAGAAGCATCAAACAAGGATGCATAGCAGACTCAACCATGGAGGCTGAGTATGTAGCAGCTTGCGAAGCAGCTAAGGAGGCAGTATGGCTTA
GAAAGTTCTTGACTGATTTGGAAGTTGTTCCGAATATGAACGTGCCCATAACACTATACTGTGACAACAGTGGGGCTGTAGCCAACTCAAAAGAACCTCGAAGCCACAAA
CGGAAGAAATTTCCAGCGAAGAAATCAAGAAGGAATCGCTGCGTTTTCGTTCGTCGGAGCGTCGTTGGCGAAGAACGGTCAAGTCTACAACGAAGGAGTTTATCTAGATC
TTTAGATCTGTTAAAGGAGTTCATTAGGAGTGCTCATGATGCAAGTGAGTTTGCATACGATGAGCCCGGTGGTGTTGAGGAGGTCAAAGAAAATTTTGGTTTAGTCTTAC
GTATGCCGTTATGTTGCCGAAATTTTCGATGTATTCGGATTGTTGCAAGTCCAAGAGTTCGAGCTGTAGCCACTCTTCCAGCTCGTAATCGCATTTCCTACAAGTTCTTC
TTTTTCCCTCAAGAAACATTCAAACATCATCACCACTGTCCCCCACAGATTCTCGGAAGGCTTCTCCTAAATTATTTCGCTGGTGAAAGGCCTTCTATCAGTCGAAGAAT
AGGGTCCAAACAATGCTTCGACACTCACTCAGAAGATCAAGAGATCACGGAGTTCATGGAATACTTAGATTCCCTGAAGAATTATGAGAAATTGGGTGTGCCTAGAGGCG
CAGGGACAGATTCTGATGATGGGTTCGATCTCGGAAGGATGAGAAGGATGATGGAGCGGCTGGGCAATCCACAATCGAAGTTTAAGACTAATGGTAGAATAATTATAGGC
CATTCACATTGCGGGAACCAAGGAAAAGGGTCCACTGCTGCCTTCCTATCTAACATTTTACGAGCAGAGGGATACTCTGTTGGCTGTTATACTAGTCCTCATATTGAAAC
TATAAGGGAACGTATTTCACTTGAAAGATCTGGAGAGATGGTCTCTGGGAAGGCACTAAACTCTCTTTTCAAAAGGAACAAAGAATTTCTTGACCAGTCAGTTGAACTTG
AAAATGGACATATTAGTCACTTTGAGGTCCTTACTGCTATGGCATTCTCACTCTTTGCTCAAGAGAAAGTTGATGTTGCAGTCATTGAGGCTGGACTTGGTGGTGCACGA
GATGCAACCAACATAATTTGCAGCTCCAGACTTGCTGCTGCAGTCATAACTTCAATTGGAGAGGAATACGTGGCTGTGCTGGGTGGCTCTTTAGAAAGCATTGCAACGGC
AAAGGCTGGAATAATTAAACATGGTTGTCCAACCATTCTGGCTGGTCCTTTCCTTCCAAGCATTGAGTGCATCCTTCGCGATAAAGCATTGTCCATGTCTTCGTCTGTAT
TATCAGCCTCAGATCCTGGAAATAAAAGTACCATAAAAGGTGTAAACCTGCTCAATGGAAGACTTTGCCAATGCTGCGACATAGTAATTCAAATAGACAATGAAAGTTAT
TGGATGTCAACCTCCCGCATGCTTGGAAGTCATCAACTTCAGAATGCAGCAACCGCAACTTGTGTTATTCTTACTCTCCGCAATTTAGGTTGGAGAATTTCAGATGTATC
AATTAGGAATGGACTAGAGCAAACATTCTTGGTTGGTAGGAGTCATTTCTTATCAGCTGAGGAAGCTGAGATTCTTGGACTACCTGGAGCAACAATATTGCTGGATGGAG
CCCACACCAAAGACTCTGCTAAAGCATTAGTGGACACCATTCAGATGACTTTTCCAGAGGCACGATTGGCTCTTGTGGTTGCAATGGCTAGTGATAAGGATCACATTGGT
TTTGCCAGAGAATTTCTTAAAGGTGGAAAATTGGAGTCCATTGTCTTAACTGAAGCCAATATTGGTGGAGCCAAATCAAGGACAACTTCAGCTGCTCTTCTAAGGGATTG
CTGGATTCAAGCATCCAATGAACTGGGCATCTCTGTTTCTCTAGAAACTAAAGATGCATCGGTATCCTCCATGAGCAAACTCGAAAACAGGCCGATATTGACTACCGAGA
CCTCGTTATTACATGCCATAAAAATCACTGTTGAGAATCTCAAGCAAAGAACGGAAGGGCAGCAACGAGGTCTAATCGTAGTAACTGGATCGCTGAACGCCATTTCAATG
GTGTTATCTTCTATTCATTCTTGA

mRNA sequence

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Protein sequence

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MLVYGAKDLILTGYTDSDFQADKDSRKSTSGSVFTLNGGAVVWRSIKQGCIADSTMEAEYVAACEAAKEAVWLRKFLTDLEVVPNMNVPITLYCDNSGAVANSKEPRSHK
RKKFPAKKSRRNRCVFVRRSVVGEERSSLQRRSLSRSLDLLKEFIRSAHDASEFAYDEPGGVEEVKENFGLVLRMPLCCRNFRCIRIVASPRVRAVATLPARNRISYKFF
FFPQETFKHHHHCPPQILGRLLLNYFAGERPSISRRIGSKQCFDTHSEDQEITEFMEYLDSLKNYEKLGVPRGAGTDSDDGFDLGRMRRMMERLGNPQSKFKTNGRIIIG
HSHCGNQGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISLERSGEMVSGKALNSLFKRNKEFLDQSVELENGHISHFEVLTAMAFSLFAQEKVDVAVIEAGLGGAR
DATNIICSSRLAAAVITSIGEEYVAVLGGSLESIATAKAGIIKHGCPTILAGPFLPSIECILRDKALSMSSSVLSASDPGNKSTIKGVNLLNGRLCQCCDIVIQIDNESY
WMSTSRMLGSHQLQNAATATCVILTLRNLGWRISDVSIRNGLEQTFLVGRSHFLSAEEAEILGLPGATILLDGAHTKDSAKALVDTIQMTFPEARLALVVAMASDKDHIG
FAREFLKGGKLESIVLTEANIGGAKSRTTSAALLRDCWIQASNELGISVSLETKDASVSSMSKLENRPILTTETSLLHAIKITVENLKQRTEGQQRGLIVVTGSLNAISM
VLSSIHS

Lag0018586 (gene) of Sponge gourd (AG-4) v1 genome