CuGenDBv2

Gene ID	Lag0032082
Organism	Luffa acutangula AG-4 (Sponge gourd (AG-4) v1)
Description	3-hydroxyisobutyrate dehydrogenase
Genome location	chr11:24141142..24143733
RNA-Seq Expression	Lag0032082
Synteny	Lag0032082
Gene Ontology terms	GO:0006551 - leucine metabolic process (biological process) GO:0006574 - valine catabolic process (biological process) GO:0008442 - 3-hydroxyisobutyrate dehydrogenase activity (molecular function) GO:0043621 - protein self-association (molecular function) GO:0050661 - NADP binding (molecular function) GO:0051287 - NAD binding (molecular function)
InterPro domains	IPR008927 - 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily IPR013328 - 6-phosphogluconate dehydrogenase, domain 2 IPR029154 - 3-hydroxyisobutyrate dehydrogenase, NAD-binding domain

Homology

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GenBank top hits

e value

%identity

Alignment

XP_023520240.1 probable 3-hydroxyisobutyrate dehydrogenase, mitochondrial isoform X1 [Cucurbita pepo subsp. pepo]

3.7e-39

81.36

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Query:  VLGVSEALALGQSLGISAETLTKVFNSSSARCWSS-SWGDGGGV-----SARDYDGGFASKLMDKDLNRAAASASEIGLKHSMTSQAHEIYKKLYEDGYE
        +LGVSEALALGQSLGISA+TLTKV NSSSARCWSS S+    GV     SA DYDGGFASKLM KDLN AAASASEIGL+H +TSQA EIYKKL EDGYE
Subjt:  VLGVSEALALGQSLGISAETLTKVFNSSSARCWSS-SWGDGGGV-----SARDYDGGFASKLMDKDLNRAAASASEIGLKHSMTSQAHEIYKKLYEDGYE

Query:  NKDFSCVFRHFYSGDDEL
        NKDFSCVFRHFYSGDDEL
Subjt:  NKDFSCVFRHFYSGDDEL

XP_038894390.1 probable 3-hydroxyisobutyrate dehydrogenase, mitochondrial isoform X1 [Benincasa hispida]

5.7e-40

81.36

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Query:  VLGVSEALALGQSLGISAETLTKVFNSSSARCWSS-SWGDGGGV-----SARDYDGGFASKLMDKDLNRAAASASEIGLKHSMTSQAHEIYKKLYEDGYE
        +LGVSEALALGQSLGISA+TLTKVFNSSSARCWSS S+    GV     SARDYDGGFASKLM KDLN AAASA E+GL+H +TSQA EIYKKL EDGYE
Subjt:  VLGVSEALALGQSLGISAETLTKVFNSSSARCWSS-SWGDGGGV-----SARDYDGGFASKLMDKDLNRAAASASEIGLKHSMTSQAHEIYKKLYEDGYE

Query:  NKDFSCVFRHFYSGDDEL
        NKDFSCVFRHFYSGDDEL
Subjt:  NKDFSCVFRHFYSGDDEL

XP_038894392.1 probable 3-hydroxyisobutyrate dehydrogenase, mitochondrial isoform X2 [Benincasa hispida]

5.7e-40

81.36

Show/hide

Query:  VLGVSEALALGQSLGISAETLTKVFNSSSARCWSS-SWGDGGGV-----SARDYDGGFASKLMDKDLNRAAASASEIGLKHSMTSQAHEIYKKLYEDGYE
        +LGVSEALALGQSLGISA+TLTKVFNSSSARCWSS S+    GV     SARDYDGGFASKLM KDLN AAASA E+GL+H +TSQA EIYKKL EDGYE
Subjt:  VLGVSEALALGQSLGISAETLTKVFNSSSARCWSS-SWGDGGGV-----SARDYDGGFASKLMDKDLNRAAASASEIGLKHSMTSQAHEIYKKLYEDGYE

Query:  NKDFSCVFRHFYSGDDEL
        NKDFSCVFRHFYSGDDEL
Subjt:  NKDFSCVFRHFYSGDDEL

XP_038894393.1 probable 3-hydroxyisobutyrate dehydrogenase, mitochondrial isoform X3 [Benincasa hispida]

5.7e-40

81.36

Show/hide

Query:  VLGVSEALALGQSLGISAETLTKVFNSSSARCWSS-SWGDGGGV-----SARDYDGGFASKLMDKDLNRAAASASEIGLKHSMTSQAHEIYKKLYEDGYE
        +LGVSEALALGQSLGISA+TLTKVFNSSSARCWSS S+    GV     SARDYDGGFASKLM KDLN AAASA E+GL+H +TSQA EIYKKL EDGYE
Subjt:  VLGVSEALALGQSLGISAETLTKVFNSSSARCWSS-SWGDGGGV-----SARDYDGGFASKLMDKDLNRAAASASEIGLKHSMTSQAHEIYKKLYEDGYE

Query:  NKDFSCVFRHFYSGDDEL
        NKDFSCVFRHFYSGDDEL
Subjt:  NKDFSCVFRHFYSGDDEL

XP_038894395.1 probable 3-hydroxyisobutyrate dehydrogenase, mitochondrial isoform X5 [Benincasa hispida]

5.7e-40

81.36

Show/hide

Query:  VLGVSEALALGQSLGISAETLTKVFNSSSARCWSS-SWGDGGGV-----SARDYDGGFASKLMDKDLNRAAASASEIGLKHSMTSQAHEIYKKLYEDGYE
        +LGVSEALALGQSLGISA+TLTKVFNSSSARCWSS S+    GV     SARDYDGGFASKLM KDLN AAASA E+GL+H +TSQA EIYKKL EDGYE
Subjt:  VLGVSEALALGQSLGISAETLTKVFNSSSARCWSS-SWGDGGGV-----SARDYDGGFASKLMDKDLNRAAASASEIGLKHSMTSQAHEIYKKLYEDGYE

Query:  NKDFSCVFRHFYSGDDEL
        NKDFSCVFRHFYSGDDEL
Subjt:  NKDFSCVFRHFYSGDDEL

TrEMBL top hits

e value

%identity

Alignment

A0A0A0M152 3-hydroxyisobutyrate dehydrogenase

3.1e-39

79.66

Show/hide

Query:  VLGVSEALALGQSLGISAETLTKVFNSSSARCWSS-SWGDGGGV-----SARDYDGGFASKLMDKDLNRAAASASEIGLKHSMTSQAHEIYKKLYEDGYE
        +LGVSEALALGQSLGISA+TLTKVFNSSSARCWSS S+    GV     SARDYDGGFA+KLM KDLN A ASA E+GL+H +TSQA EIYKKL EDGYE
Subjt:  VLGVSEALALGQSLGISAETLTKVFNSSSARCWSS-SWGDGGGV-----SARDYDGGFASKLMDKDLNRAAASASEIGLKHSMTSQAHEIYKKLYEDGYE

Query:  NKDFSCVFRHFYSGDDEL
        NKDFSCVFRHFYSGDDEL
Subjt:  NKDFSCVFRHFYSGDDEL

A0A6J1EHG8 3-hydroxyisobutyrate dehydrogenase

6.8e-39

80.51

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Query:  VLGVSEALALGQSLGISAETLTKVFNSSSARCWSS-SWGDGGGV-----SARDYDGGFASKLMDKDLNRAAASASEIGLKHSMTSQAHEIYKKLYEDGYE
        +LGVSEALALGQSLGISA+TLTKV NSSSARCWSS S+    GV     SA DYDGGFASKLM KDLN AAASASEIGL+H +TSQA EIYKKL EDGYE
Subjt:  VLGVSEALALGQSLGISAETLTKVFNSSSARCWSS-SWGDGGGV-----SARDYDGGFASKLMDKDLNRAAASASEIGLKHSMTSQAHEIYKKLYEDGYE

Query:  NKDFSCVFRHFYSGDDEL
        NKDFSCVFRHFYSGD+EL
Subjt:  NKDFSCVFRHFYSGDDEL

A0A6J1EHZ4 3-hydroxyisobutyrate dehydrogenase

6.8e-39

80.51

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Query:  VLGVSEALALGQSLGISAETLTKVFNSSSARCWSS-SWGDGGGV-----SARDYDGGFASKLMDKDLNRAAASASEIGLKHSMTSQAHEIYKKLYEDGYE
        +LGVSEALALGQSLGISA+TLTKV NSSSARCWSS S+    GV     SA DYDGGFASKLM KDLN AAASASEIGL+H +TSQA EIYKKL EDGYE
Subjt:  VLGVSEALALGQSLGISAETLTKVFNSSSARCWSS-SWGDGGGV-----SARDYDGGFASKLMDKDLNRAAASASEIGLKHSMTSQAHEIYKKLYEDGYE

Query:  NKDFSCVFRHFYSGDDEL
        NKDFSCVFRHFYSGD+EL
Subjt:  NKDFSCVFRHFYSGDDEL

A0A6J1KER6 3-hydroxyisobutyrate dehydrogenase

2.0e-38

80.51

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Query:  VLGVSEALALGQSLGISAETLTKVFNSSSARCWSS-SWGDGGGV-----SARDYDGGFASKLMDKDLNRAAASASEIGLKHSMTSQAHEIYKKLYEDGYE
        +LGVSEALALGQSLGISA+TLTKV NSSSARCWSS S+    GV     SA DYDGGFASKLM KDLN AAASASEIGL+H +TSQA EIYKKL EDGYE
Subjt:  VLGVSEALALGQSLGISAETLTKVFNSSSARCWSS-SWGDGGGV-----SARDYDGGFASKLMDKDLNRAAASASEIGLKHSMTSQAHEIYKKLYEDGYE

Query:  NKDFSCVFRHFYSGDDEL
        NKDFSCVFRHFYSG DEL
Subjt:  NKDFSCVFRHFYSGDDEL

A0A6J1KJE2 3-hydroxyisobutyrate dehydrogenase

2.0e-38

80.51

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Query:  VLGVSEALALGQSLGISAETLTKVFNSSSARCWSS-SWGDGGGV-----SARDYDGGFASKLMDKDLNRAAASASEIGLKHSMTSQAHEIYKKLYEDGYE
        +LGVSEALALGQSLGISA+TLTKV NSSSARCWSS S+    GV     SA DYDGGFASKLM KDLN AAASASEIGL+H +TSQA EIYKKL EDGYE
Subjt:  VLGVSEALALGQSLGISAETLTKVFNSSSARCWSS-SWGDGGGV-----SARDYDGGFASKLMDKDLNRAAASASEIGLKHSMTSQAHEIYKKLYEDGYE

Query:  NKDFSCVFRHFYSGDDEL
        NKDFSCVFRHFYSG DEL
Subjt:  NKDFSCVFRHFYSGDDEL

SwissProt top hits

e value

%identity

Alignment

P31937 3-hydroxyisobutyrate dehydrogenase, mitochondrial

1.4e-12

41.28

Show/hide

Query:  VLGVSEALALGQSLGISAETLTKVFNSSSARCWSSSWGD------GGGVSARDYDGGFASKLMDKDLNRAAASASEIGLKHSMTSQAHEIYKKLYEDGYE
        ++G +EA+ LG  LG+  + L K+ N SS RCWSS   +       G  SA +Y GGF + LM KDL  A  SA+       + S AH+IY+ +   GY 
Subjt:  VLGVSEALALGQSLGISAETLTKVFNSSSARCWSSSWGD------GGGVSARDYDGGFASKLMDKDLNRAAASASEIGLKHSMTSQAHEIYKKLYEDGYE

Query:  NKDFSCVFR
         KDFS VF+
Subjt:  NKDFSCVFR

Q2HJD7 3-hydroxyisobutyrate dehydrogenase, mitochondrial

2.1e-13

42.2

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Query:  VLGVSEALALGQSLGISAETLTKVFNSSSARCWSSSWGD------GGGVSARDYDGGFASKLMDKDLNRAAASASEIGLKHSMTSQAHEIYKKLYEDGYE
        ++G +EA+ LG  LG+  + L K+ N SS RCWSS   +       G  SA +Y GGF + LM KDL  A  SA+       + SQAH+IY+ +   GY 
Subjt:  VLGVSEALALGQSLGISAETLTKVFNSSSARCWSSSWGD------GGGVSARDYDGGFASKLMDKDLNRAAASASEIGLKHSMTSQAHEIYKKLYEDGYE

Query:  NKDFSCVFR
         KDFS VF+
Subjt:  NKDFSCVFR

Q5R5E7 3-hydroxyisobutyrate dehydrogenase, mitochondrial

1.4e-12

41.28

Show/hide

Query:  VLGVSEALALGQSLGISAETLTKVFNSSSARCWSSSWGD------GGGVSARDYDGGFASKLMDKDLNRAAASASEIGLKHSMTSQAHEIYKKLYEDGYE
        ++G +EA+ LG  LG+  + L K+ N SS RCWSS   +       G  SA +Y GGF + LM KDL  A  SA+       + S AH+IY+ +   GY 
Subjt:  VLGVSEALALGQSLGISAETLTKVFNSSSARCWSSSWGD------GGGVSARDYDGGFASKLMDKDLNRAAASASEIGLKHSMTSQAHEIYKKLYEDGYE

Query:  NKDFSCVFR
         KDFS VF+
Subjt:  NKDFSCVFR

Q99L13 3-hydroxyisobutyrate dehydrogenase, mitochondrial

6.9e-12

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Query:  VLGVSEALALGQSLGISAETLTKVFNSSSARCWSS-SWGDGGGV-----SARDYDGGFASKLMDKDLNRAAASASEIGLKHSMTSQAHEIYKKLYEDGYE
        ++G +EA+ LG   G+  + L K+ N SS RCWSS ++    GV     S+ +Y GGF + LM KDL  A  SA+       + S AH+IY+ +   GY 
Subjt:  VLGVSEALALGQSLGISAETLTKVFNSSSARCWSS-SWGDGGGV-----SARDYDGGFASKLMDKDLNRAAASASEIGLKHSMTSQAHEIYKKLYEDGYE

Query:  NKDFSCVFRH
         KDFS VF++
Subjt:  NKDFSCVFRH

Q9SUC0 Probable 3-hydroxyisobutyrate dehydrogenase, mitochondrial

5.4e-33

66.1

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Query:  VLGVSEALALGQSLGISAETLTKVFNSSSARCWSS-SWGDGGGV-----SARDYDGGFASKLMDKDLNRAAASASEIGLKHSMTSQAHEIYKKLYEDGYE
        +LG SEALALGQSLGISA TLT+V N+SS RCWSS ++    GV     S+RDY+GGFASKLM KDLN AAASA E+G K  + S+A EIYKK+ E+G+E
Subjt:  VLGVSEALALGQSLGISAETLTKVFNSSSARCWSS-SWGDGGGV-----SARDYDGGFASKLMDKDLNRAAASASEIGLKHSMTSQAHEIYKKLYEDGYE

Query:  NKDFSCVFRHFYSGDDEL
         KDFSCVFRHFY+G DE+
Subjt:  NKDFSCVFRHFYSGDDEL

Arabidopsis top hits

e value

%identity

Alignment

AT4G20930.1 6-phosphogluconate dehydrogenase family protein

3.8e-34

66.1

Show/hide

Query:  VLGVSEALALGQSLGISAETLTKVFNSSSARCWSS-SWGDGGGV-----SARDYDGGFASKLMDKDLNRAAASASEIGLKHSMTSQAHEIYKKLYEDGYE
        +LG SEALALGQSLGISA TLT+V N+SS RCWSS ++    GV     S+RDY+GGFASKLM KDLN AAASA E+G K  + S+A EIYKK+ E+G+E
Subjt:  VLGVSEALALGQSLGISAETLTKVFNSSSARCWSS-SWGDGGGV-----SARDYDGGFASKLMDKDLNRAAASASEIGLKHSMTSQAHEIYKKLYEDGYE

Query:  NKDFSCVFRHFYSGDDEL
         KDFSCVFRHFY+G DE+
Subjt:  NKDFSCVFRHFYSGDDEL

Sequences

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CDS sequence

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ATGAGGGTTCAGGAGCTGAAGAAAGCCTCAAAAGGTGTCTGCGTGGAAAGTCACAAAACAACAACTCTAAAAGGATTGGATGTGCATTTTGGAGATGTTTCACAATCAGT
CACTTCCAGCAAATTATGGCTGCCTGTCATTGTTGAAGAAGAGGCGTTATGGTTGGTGGTTCTGAGGAAGCCTACCATGCTGCAAAAGCCTTGTTTCTTTCAATGGGCAA
AAGTTCAGTTTATTGTGGTGGAGCTGGAAATGGTAAGCGAAGATTTGCAACAACTTGGCAATGGCTGTGAGTATGTGCTTGGTGTTTCAGAAGCTTTAGCTCTAGGCCAG
TCTCTTGGAATTTCTGCAGAAACTCTTACAAAAGTATTCAATTCATCAAGTGCTCGCTGTTGGAGTAGTTCCTGGGGTGATGGAGGAGGTGTCTCTGCAAGAGATTATGA
TGGTGGATTCGCATCAAAGCTTATGGATAAAGATCTAAACCGTGCAGCAGCATCAGCTAGTGAAATTGGCCTCAAACATTCAATGACCTCTCAGGCGCATGAGATATACA
AAAAGTTGTACGAGGATGGATATGAAAACAAGGACTTCTCTTGTGTTTTTCGTCATTTTTACTCGGGCGACGACGAGTTATAA

mRNA sequence

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Protein sequence

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MRVQELKKASKGVCVESHKTTTLKGLDVHFGDVSQSVTSSKLWLPVIVEEEALWLVVLRKPTMLQKPCFFQWAKVQFIVVELEMVSEDLQQLGNGCEYVLGVSEALALGQ
SLGISAETLTKVFNSSSARCWSSSWGDGGGVSARDYDGGFASKLMDKDLNRAAASASEIGLKHSMTSQAHEIYKKLYEDGYENKDFSCVFRHFYSGDDEL

Lag0032082 (gene) of Sponge gourd (AG-4) v1 genome