CuGenDBv2

Gene ID	Lag0032094
Organism	Luffa acutangula AG-4 (Sponge gourd (AG-4) v1)
Description	3-hydroxyisobutyrate dehydrogenase
Genome location	chr11:24461738..24469134
RNA-Seq Expression	Lag0032094
Synteny	Lag0032094
Gene Ontology terms	GO:0006551 - leucine metabolic process (biological process) GO:0006574 - valine catabolic process (biological process) GO:0008442 - 3-hydroxyisobutyrate dehydrogenase activity (molecular function) GO:0043621 - protein self-association (molecular function) GO:0050661 - NADP binding (molecular function) GO:0051287 - NAD binding (molecular function)
InterPro domains	IPR008927 - 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily IPR013328 - 6-phosphogluconate dehydrogenase, domain 2

Homology

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GenBank top hits

e value

%identity

Alignment

TYK05539.1 Beta-galactosidase [Cucumis melo var. makuwa]

2.5e-15

73.24

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Query:  LEMVSEDLQQLGNGCE------YVLGVSEALALGQSLGISAETLTKVFNSSSARCWSSESYNPVPGVMEEV
        L+ V  DL Q    C        +LGVSEALALGQSLGISA+TLTKVFNSSSARCWSSESYNPVPGVMEEV
Subjt:  LEMVSEDLQQLGNGCE------YVLGVSEALALGQSLGISAETLTKVFNSSSARCWSSESYNPVPGVMEEV

XP_004135548.1 probable 3-hydroxyisobutyrate dehydrogenase, mitochondrial isoform X1 [Cucumis sativus]

1.2e-14

95.83

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Query:  VLGVSEALALGQSLGISAETLTKVFNSSSARCWSSESYNPVPGVMEEV
        +LGVSEALALGQSLGISA+TLTKVFNSSSARCWSSESYNPVPGVMEEV
Subjt:  VLGVSEALALGQSLGISAETLTKVFNSSSARCWSSESYNPVPGVMEEV

XP_008445335.1 PREDICTED: probable 3-hydroxyisobutyrate dehydrogenase, mitochondrial isoform X2 [Cucumis melo]

1.2e-14

95.83

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Query:  VLGVSEALALGQSLGISAETLTKVFNSSSARCWSSESYNPVPGVMEEV
        +LGVSEALALGQSLGISA+TLTKVFNSSSARCWSSESYNPVPGVMEEV
Subjt:  VLGVSEALALGQSLGISAETLTKVFNSSSARCWSSESYNPVPGVMEEV

XP_038894390.1 probable 3-hydroxyisobutyrate dehydrogenase, mitochondrial isoform X1 [Benincasa hispida]

1.2e-14

95.83

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Query:  VLGVSEALALGQSLGISAETLTKVFNSSSARCWSSESYNPVPGVMEEV
        +LGVSEALALGQSLGISA+TLTKVFNSSSARCWSSESYNPVPGVMEEV
Subjt:  VLGVSEALALGQSLGISAETLTKVFNSSSARCWSSESYNPVPGVMEEV

XP_038894395.1 probable 3-hydroxyisobutyrate dehydrogenase, mitochondrial isoform X5 [Benincasa hispida]

1.2e-14

95.83

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Query:  VLGVSEALALGQSLGISAETLTKVFNSSSARCWSSESYNPVPGVMEEV
        +LGVSEALALGQSLGISA+TLTKVFNSSSARCWSSESYNPVPGVMEEV
Subjt:  VLGVSEALALGQSLGISAETLTKVFNSSSARCWSSESYNPVPGVMEEV

TrEMBL top hits

e value

%identity

Alignment

A0A0A0M152 3-hydroxyisobutyrate dehydrogenase

5.9e-15

95.83

Show/hide

Query:  VLGVSEALALGQSLGISAETLTKVFNSSSARCWSSESYNPVPGVMEEV
        +LGVSEALALGQSLGISA+TLTKVFNSSSARCWSSESYNPVPGVMEEV
Subjt:  VLGVSEALALGQSLGISAETLTKVFNSSSARCWSSESYNPVPGVMEEV

A0A1S3BBY5 3-hydroxyisobutyrate dehydrogenase

5.9e-15

95.83

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Query:  VLGVSEALALGQSLGISAETLTKVFNSSSARCWSSESYNPVPGVMEEV
        +LGVSEALALGQSLGISA+TLTKVFNSSSARCWSSESYNPVPGVMEEV
Subjt:  VLGVSEALALGQSLGISAETLTKVFNSSSARCWSSESYNPVPGVMEEV

A0A1S3BCG2 3-hydroxyisobutyrate dehydrogenase

5.9e-15

95.83

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Query:  VLGVSEALALGQSLGISAETLTKVFNSSSARCWSSESYNPVPGVMEEV
        +LGVSEALALGQSLGISA+TLTKVFNSSSARCWSSESYNPVPGVMEEV
Subjt:  VLGVSEALALGQSLGISAETLTKVFNSSSARCWSSESYNPVPGVMEEV

A0A1S3BD74 3-hydroxyisobutyrate dehydrogenase

5.9e-15

95.83

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Query:  VLGVSEALALGQSLGISAETLTKVFNSSSARCWSSESYNPVPGVMEEV
        +LGVSEALALGQSLGISA+TLTKVFNSSSARCWSSESYNPVPGVMEEV
Subjt:  VLGVSEALALGQSLGISAETLTKVFNSSSARCWSSESYNPVPGVMEEV

A0A5D3C565 Beta-galactosidase

1.2e-15

73.24

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Query:  LEMVSEDLQQLGNGCE------YVLGVSEALALGQSLGISAETLTKVFNSSSARCWSSESYNPVPGVMEEV
        L+ V  DL Q    C        +LGVSEALALGQSLGISA+TLTKVFNSSSARCWSSESYNPVPGVMEEV
Subjt:  LEMVSEDLQQLGNGCE------YVLGVSEALALGQSLGISAETLTKVFNSSSARCWSSESYNPVPGVMEEV

SwissProt top hits

e value

%identity

Alignment

P31937 3-hydroxyisobutyrate dehydrogenase, mitochondrial

8.8e-08

54.17

Show/hide

Query:  VLGVSEALALGQSLGISAETLTKVFNSSSARCWSSESYNPVPGVMEEV
        ++G +EA+ LG  LG+  + L K+ N SS RCWSS++YNPVPGVM+ V
Subjt:  VLGVSEALALGQSLGISAETLTKVFNSSSARCWSSESYNPVPGVMEEV

Q2HJD7 3-hydroxyisobutyrate dehydrogenase, mitochondrial

8.8e-08

54.17

Show/hide

Query:  VLGVSEALALGQSLGISAETLTKVFNSSSARCWSSESYNPVPGVMEEV
        ++G +EA+ LG  LG+  + L K+ N SS RCWSS++YNPVPGVM+ V
Subjt:  VLGVSEALALGQSLGISAETLTKVFNSSSARCWSSESYNPVPGVMEEV

Q5R5E7 3-hydroxyisobutyrate dehydrogenase, mitochondrial

8.8e-08

54.17

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Query:  VLGVSEALALGQSLGISAETLTKVFNSSSARCWSSESYNPVPGVMEEV
        ++G +EA+ LG  LG+  + L K+ N SS RCWSS++YNPVPGVM+ V
Subjt:  VLGVSEALALGQSLGISAETLTKVFNSSSARCWSSESYNPVPGVMEEV

Q9SUC0 Probable 3-hydroxyisobutyrate dehydrogenase, mitochondrial

5.3e-13

77.08

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Query:  VLGVSEALALGQSLGISAETLTKVFNSSSARCWSSESYNPVPGVMEEV
        +LG SEALALGQSLGISA TLT+V N+SS RCWSS++YNPVPGVM+ V
Subjt:  VLGVSEALALGQSLGISAETLTKVFNSSSARCWSSESYNPVPGVMEEV

Q9XTI0 Probable 3-hydroxyisobutyrate dehydrogenase, mitochondrial

2.6e-07

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Query:  VLGVSEALALGQSLGISAETLTKVFNSSSARCWSSESYNPVPGVMEEV
        ++ V+E + LG S+G+ A+ L  + N+SS RCWSS++YNPVPGV+E +
Subjt:  VLGVSEALALGQSLGISAETLTKVFNSSSARCWSSESYNPVPGVMEEV

Arabidopsis top hits

e value

%identity

Alignment

AT4G20930.1 6-phosphogluconate dehydrogenase family protein

3.8e-14

77.08

Show/hide

Query:  VLGVSEALALGQSLGISAETLTKVFNSSSARCWSSESYNPVPGVMEEV
        +LG SEALALGQSLGISA TLT+V N+SS RCWSS++YNPVPGVM+ V
Subjt:  VLGVSEALALGQSLGISAETLTKVFNSSSARCWSSESYNPVPGVMEEV

Sequences

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CDS sequence

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ATGCTTGTTACTAGTCATATCTTGGCATTGATGTTCCTGCTGCTCATATCTCTTTTCCAACTCAGCTATTCTAAATGCCAATTGCGTAGCTTGGTAATTTTGGACCACCC
CGATGCACAAGGAGCTGACGAGGACAATCGGGCAGAAATCGGACTGGAAGATGGACCCGGGCGGGGAAACGGGCTAGTGGACCAGGCCAAGACCGAAGGGGTCGGGATTT
TGGCCCGACCCCATGGTCGGCCCGCGCGACTCTGTTCGGTCCATACTGCCTCTGGCCGCCTCGGTTTCGCCTGGTTCGTCCCAAAATGCCTTCGAATTCCTGGAAACCCT
AGGAGGATGAGCAGCATCGGAGTCGGTGTGGCTAGCACCACACCGGTGTGTAGGTTTTCCGTCTTGCAGGCCACGTCTTCCCCCTCATCTACAAATTTACCGTTGGTGGC
ACGTGAAGGTCAGTTCTTCTCCCAAATTTCCACGGTGAAGATGACCACCGTCGCCGTTTTGATGGCGGCGCTGCAACGAATGGGGACTCTCTACATGCGAGGTACTCGAG
CCATGGCAGACCTCGCAGTCGTCCACTTCAGAGTGGTAAGGAACCGTTCTACAGAAATGGTCGAGGCTCTTTCCATCGTGAATAAGGAGCTGAAGAAAGCCTCAAAAGGT
GTCTGCGTGGAAAGTCACAAAACAACAACTCTAAAAGGATTGGATGTGCATTTTGGAGATGTTTCACAATCAGTCACTTCCAGCAAATTATGGCTGCCTGTCATTGTTGA
AGAAGAGGCGTTATGGTTGGTGGTTCTGAGGAAGCCTACCATGCTGCAAAAGCCTTGTTTCTTTCAATGGGCAAAAGTTCAGTTTATTGTGGTGGAGCTGGAAATGGTAA
GCGAAGATTTGCAACAACTTGGCAATGGCTGTGAGTATGTGCTTGGTGTTTCAGAAGCTTTAGCTCTAGGCCAGTCTCTTGGAATTTCTGCAGAAACTCTTACAAAAGTA
TTCAATTCATCAAGTGCTCGCTGTTGGAGTAGCGAAAGTTACAATCCAGTTCCTGGGGTGATGGAGGAGGTGTCTCTGCAAGAGATTATGATGGTGGATTCGCATCAAAG
CTTATGCGAGGGAATAGGGATCATGGTGCAGTGTCCATTAGCAATTCTCTTTGTTGGGATATTCCTCTCCCTTCTTTCGTTGGATTGGTTATCCCGTGGTTATTAG

mRNA sequence

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Protein sequence

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MLVTSHILALMFLLLISLFQLSYSKCQLRSLVILDHPDAQGADEDNRAEIGLEDGPGRGNGLVDQAKTEGVGILARPHGRPARLCSVHTASGRLGFAWFVPKCLRIPGNP
RRMSSIGVGVASTTPVCRFSVLQATSSPSSTNLPLVAREGQFFSQISTVKMTTVAVLMAALQRMGTLYMRGTRAMADLAVVHFRVVRNRSTEMVEALSIVNKELKKASKG
VCVESHKTTTLKGLDVHFGDVSQSVTSSKLWLPVIVEEEALWLVVLRKPTMLQKPCFFQWAKVQFIVVELEMVSEDLQQLGNGCEYVLGVSEALALGQSLGISAETLTKV
FNSSSARCWSSESYNPVPGVMEEVSLQEIMMVDSHQSLCEGIGIMVQCPLAILFVGIFLSLLSLDWLSRGY

Lag0032094 (gene) of Sponge gourd (AG-4) v1 genome