CuGenDBv2

Gene ID	Lag0037578
Organism	Luffa acutangula AG-4 (Sponge gourd (AG-4) v1)
Description	3-hydroxy-3-methylglutaryl-coenzyme A reductase
Genome location	chr2:7397479..7398251
RNA-Seq Expression	Lag0037578
Synteny	Lag0037578
Gene Ontology terms	GO:0009646 - response to absence of light (biological process) GO:0009753 - response to jasmonic acid (biological process) GO:0015936 - coenzyme A metabolic process (biological process) GO:0016104 - triterpenoid biosynthetic process (biological process) GO:0016135 - saponin biosynthetic process (biological process) GO:0005778 - peroxisomal membrane (cellular component) GO:0005789 - endoplasmic reticulum membrane (cellular component) GO:0016021 - integral component of membrane (cellular component) GO:0031969 - chloroplast membrane (cellular component) GO:0004420 - hydroxymethylglutaryl-CoA reductase (NADPH) activity (molecular function)
InterPro domains	IPR002202 - Hydroxymethylglutaryl-CoA reductase, class I/II IPR009023 - Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain superfamily

Homology

Show/hide homology

GenBank top hits

e value

%identity

Alignment

TKY57061.1 3-hydroxy-3-methylglutaryl-coenzyme A reductase [Spatholobus suberectus]

2.1e-16

63.16

Show/hide

Query:  SSASCSDFRFTHALARAISPPELFS---RNVLDFLQEDFPDMDVIGISGNFCLDKKPAAVNWVEGRVKYVVCEAII
        SSAS  D     A+    +P        +NVLDFLQ DFPDMDVIGISGN+C DKKPAAVNW+EGR K VVCEAII
Subjt:  SSASCSDFRFTHALARAISPPELFS---RNVLDFLQEDFPDMDVIGISGNFCLDKKPAAVNWVEGRVKYVVCEAII

XP_022928221.1 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1-like [Cucurbita moschata]

6.2e-16

89.58

Show/hide

Query:  RNVLDFLQEDFPDMDVIGISGNFCLDKKPAAVNWVEGRVKYVVCEAII
        +NVLDFLQEDFPDMDVIGISGNFC DKKPAAVNW+EGR K VVCEAII
Subjt:  RNVLDFLQEDFPDMDVIGISGNFCLDKKPAAVNWVEGRVKYVVCEAII

XP_022989367.1 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1-like [Cucurbita maxima]

6.2e-16

89.58

Show/hide

Query:  RNVLDFLQEDFPDMDVIGISGNFCLDKKPAAVNWVEGRVKYVVCEAII
        +NVLDFLQEDFPDMDVIGISGNFC DKKPAAVNW+EGR K VVCEAII
Subjt:  RNVLDFLQEDFPDMDVIGISGNFCLDKKPAAVNWVEGRVKYVVCEAII

XP_023529829.1 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1-like [Cucurbita pepo subsp. pepo]

2.8e-16

70.77

Show/hide

Query:  RFTHALARAISPPELFSRNVLDFLQEDFPDMDVIGISGNFCLDKKPAAVNWVEGRVKYVVCEAII
        RF+ +   A+    +   NVLDFLQEDFPDMDVIGISGNFC DKKPAAVNW+EGR K VVCEAII
Subjt:  RFTHALARAISPPELFSRNVLDFLQEDFPDMDVIGISGNFCLDKKPAAVNWVEGRVKYVVCEAII

XP_038888927.1 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1-like [Benincasa hispida]

6.2e-16

89.58

Show/hide

Query:  RNVLDFLQEDFPDMDVIGISGNFCLDKKPAAVNWVEGRVKYVVCEAII
        +NVLDFLQEDFPDMDVIGISGNFC DKKPAAVNW+EGR K VVCEAII
Subjt:  RNVLDFLQEDFPDMDVIGISGNFCLDKKPAAVNWVEGRVKYVVCEAII

TrEMBL top hits

e value

%identity

Alignment

A0A0A0K2Z2 3-hydroxy-3-methylglutaryl coenzyme A reductase

3.9e-16

87.5

Show/hide

Query:  RNVLDFLQEDFPDMDVIGISGNFCLDKKPAAVNWVEGRVKYVVCEAII
        +NVLDFLQEDFPDMDVIGISGNFC DKKPAAVNW+EGR K VVCEA+I
Subjt:  RNVLDFLQEDFPDMDVIGISGNFCLDKKPAAVNWVEGRVKYVVCEAII

A0A5A7UUL1 3-hydroxy-3-methylglutaryl coenzyme A reductase

3.9e-16

87.5

Show/hide

Query:  RNVLDFLQEDFPDMDVIGISGNFCLDKKPAAVNWVEGRVKYVVCEAII
        +NVLDFLQEDFPDMDVIGISGNFC DKKPAAVNW+EGR K VVCEA+I
Subjt:  RNVLDFLQEDFPDMDVIGISGNFCLDKKPAAVNWVEGRVKYVVCEAII

A0A6J1EJQ3 3-hydroxy-3-methylglutaryl coenzyme A reductase

3.0e-16

89.58

Show/hide

Query:  RNVLDFLQEDFPDMDVIGISGNFCLDKKPAAVNWVEGRVKYVVCEAII
        +NVLDFLQEDFPDMDVIGISGNFC DKKPAAVNW+EGR K VVCEAII
Subjt:  RNVLDFLQEDFPDMDVIGISGNFCLDKKPAAVNWVEGRVKYVVCEAII

A0A6J1JQ23 3-hydroxy-3-methylglutaryl coenzyme A reductase

3.0e-16

89.58

Show/hide

Query:  RNVLDFLQEDFPDMDVIGISGNFCLDKKPAAVNWVEGRVKYVVCEAII
        +NVLDFLQEDFPDMDVIGISGNFC DKKPAAVNW+EGR K VVCEAII
Subjt:  RNVLDFLQEDFPDMDVIGISGNFCLDKKPAAVNWVEGRVKYVVCEAII

Q39628 Hydroxymethylglutaryl-CoA reductase (NADPH) (Fragment)

3.9e-16

87.5

Show/hide

Query:  RNVLDFLQEDFPDMDVIGISGNFCLDKKPAAVNWVEGRVKYVVCEAII
        +NVLDFLQEDFPDMDVIGISGNFC DKKPAAVNW+EGR K VVCEA+I
Subjt:  RNVLDFLQEDFPDMDVIGISGNFCLDKKPAAVNWVEGRVKYVVCEAII

SwissProt top hits

e value

%identity

Alignment

A0A0A1C3I2 3-hydroxy-3-methylglutaryl coenzyme A reductase 1

9.0e-18

85.42

Show/hide

Query:  RNVLDFLQEDFPDMDVIGISGNFCLDKKPAAVNWVEGRVKYVVCEAII
        +NVL+FLQ DFPDMDVIGISGNFC DKKPAAVNW+EGR K VVCEAII
Subjt:  RNVLDFLQEDFPDMDVIGISGNFCLDKKPAAVNWVEGRVKYVVCEAII

O64966 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1

4.1e-18

87.5

Show/hide

Query:  RNVLDFLQEDFPDMDVIGISGNFCLDKKPAAVNWVEGRVKYVVCEAII
        +NVLDFLQ DFPDMDVIGISGNFC DKKPAAVNW+EGR K VVCEAII
Subjt:  RNVLDFLQEDFPDMDVIGISGNFCLDKKPAAVNWVEGRVKYVVCEAII

O64967 3-hydroxy-3-methylglutaryl-coenzyme A reductase 2

4.1e-18

87.5

Show/hide

Query:  RNVLDFLQEDFPDMDVIGISGNFCLDKKPAAVNWVEGRVKYVVCEAII
        +NVLDFLQ DFPDMDVIGISGNFC DKKPAAVNW+EGR K VVCEAII
Subjt:  RNVLDFLQEDFPDMDVIGISGNFCLDKKPAAVNWVEGRVKYVVCEAII

P48021 3-hydroxy-3-methylglutaryl-coenzyme A reductase

5.3e-18

83.33

Show/hide

Query:  RNVLDFLQEDFPDMDVIGISGNFCLDKKPAAVNWVEGRVKYVVCEAII
        +NVLDFLQ+DFPDMDVIGISGN+C DKKPAAVNW+EGR K VVCEA+I
Subjt:  RNVLDFLQEDFPDMDVIGISGNFCLDKKPAAVNWVEGRVKYVVCEAII

U5JCC6 3-hydroxy-3-methylglutaryl coenzyme A reductase 2-B

1.5e-17

83.33

Show/hide

Query:  RNVLDFLQEDFPDMDVIGISGNFCLDKKPAAVNWVEGRVKYVVCEAII
        +NVLDFLQ DFPDMDV+GISGN+C DKKPAAVNW+EGR K VVCEAII
Subjt:  RNVLDFLQEDFPDMDVIGISGNFCLDKKPAAVNWVEGRVKYVVCEAII

Arabidopsis top hits

e value

%identity

Alignment

AT1G76490.1 hydroxy methylglutaryl CoA reductase 1

5.4e-18

79.17

Show/hide

Query:  RNVLDFLQEDFPDMDVIGISGNFCLDKKPAAVNWVEGRVKYVVCEAII
        +NVL++L +DFPDMDVIGISGNFC DKKPAAVNW+EGR K VVCEA+I
Subjt:  RNVLDFLQEDFPDMDVIGISGNFCLDKKPAAVNWVEGRVKYVVCEAII

AT2G17370.1 3-hydroxy-3-methylglutaryl-CoA reductase 2

1.7e-16

72.92

Show/hide

Query:  RNVLDFLQEDFPDMDVIGISGNFCLDKKPAAVNWVEGRVKYVVCEAII
        +NVLDF++ +FPDMDVIGISGN+C DKK +AVNW+EGR K+VVCEA I
Subjt:  RNVLDFLQEDFPDMDVIGISGNFCLDKKPAAVNWVEGRVKYVVCEAII

Sequences

Show/hide sequences

CDS sequence

Show/hide CDS sequence

ATGGTGCGTGTTGAATCTTCTGCTTCGTGTTCTGATTTTCGATTTACTCATGCGCTCGCTCGCGCCATTTCTCCTCCTGAGCTTTTCTCTCGGAACGTTCTCGATTTCTT
ACAGGAGGATTTCCCTGACATGGATGTAATCGGCATTTCCGGAAATTTCTGCTTGGATAAGAAACCGGCTGCTGTGAACTGGGTTGAAGGAAGGGTGAAGTACGTGGTTT
GTGAGGCCATAATTTAA

mRNA sequence

Show/hide mRNA sequence

Protein sequence

Show/hide protein sequence

MVRVESSASCSDFRFTHALARAISPPELFSRNVLDFLQEDFPDMDVIGISGNFCLDKKPAAVNWVEGRVKYVVCEAII

Lag0037578 (gene) of Sponge gourd (AG-4) v1 genome