CuGenDBv2

Gene ID	Lag0039101
Organism	Luffa acutangula AG-4 (Sponge gourd (AG-4) v1)
Description	DNA mismatch repair protein MLH1
Genome location	chr2:35908262..35908979
RNA-Seq Expression	Lag0039101
Synteny	Lag0039101
Gene Ontology terms	GO:0006298 - mismatch repair (biological process) GO:0005634 - nucleus (cellular component) GO:0032300 - mismatch repair complex (cellular component) GO:0005524 - ATP binding (molecular function) GO:0016887 - ATPase activity (molecular function) GO:0030983 - mismatched DNA binding (molecular function)
InterPro domains	IPR038973 - DNA mismatch repair protein MutL/Mlh/Pms

Homology

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GenBank top hits

e value

%identity

Alignment

XP_022159006.1 DNA mismatch repair protein MLH1 [Momordica charantia]

2.6e-40

92.08

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Query:  QVSLLNQEVIIERIQSAVDSKLRSSNDMRTFQEQDVESSAACQMVISNDYAQNSSQSGPKSQKVPVHKMVRTDSTDPAGRLHAYVQMKPPGLPESSLTAV
        +V+LLNQEVIIERIQSAV+SKLRSSND RTFQEQDVESSAA QMV+SNDY QNSSQSG KSQKVPVHKMVRTDSTDPAGRLHAYVQMKPPGLPESSLTAV
Subjt:  QVSLLNQEVIIERIQSAVDSKLRSSNDMRTFQEQDVESSAACQMVISNDYAQNSSQSGPKSQKVPVHKMVRTDSTDPAGRLHAYVQMKPPGLPESSLTAV

Query:  R
        R
Subjt:  R

XP_022972874.1 DNA mismatch repair protein MLH1 isoform X2 [Cucurbita maxima]

1.1e-38

89.11

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Query:  QVSLLNQEVIIERIQSAVDSKLRSSNDMRTFQEQDVESSAACQMVISNDYAQNSSQSGPKSQKVPVHKMVRTDSTDPAGRLHAYVQMKPPGLPESSLTAV
        +VSLLNQEVIIERIQSAV+SKLRSSND RTFQEQDVESSAA QMVIS+DY QNSSQSG KSQK+PV KMVRTDSTDPAGRLHAYVQMKPPGLPESSL  V
Subjt:  QVSLLNQEVIIERIQSAVDSKLRSSNDMRTFQEQDVESSAACQMVISNDYAQNSSQSGPKSQKVPVHKMVRTDSTDPAGRLHAYVQMKPPGLPESSLTAV

Query:  R
        R
Subjt:  R

XP_023524451.1 DNA mismatch repair protein MLH1 isoform X2 [Cucurbita pepo subsp. pepo]

1.9e-38

89.11

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Query:  QVSLLNQEVIIERIQSAVDSKLRSSNDMRTFQEQDVESSAACQMVISNDYAQNSSQSGPKSQKVPVHKMVRTDSTDPAGRLHAYVQMKPPGLPESSLTAV
        +VSLLNQEVIIERIQSAV+SKLRSSND RTFQEQDVESSAA QMVIS+DY QNSSQSG KSQKVPV KMVRTDSTDPAGRLHAY+QMKPPGLPESSL  V
Subjt:  QVSLLNQEVIIERIQSAVDSKLRSSNDMRTFQEQDVESSAACQMVISNDYAQNSSQSGPKSQKVPVHKMVRTDSTDPAGRLHAYVQMKPPGLPESSLTAV

Query:  R
        R
Subjt:  R

XP_038884719.1 DNA mismatch repair protein MLH1-like isoform X1 [Benincasa hispida]

3.2e-38

88.12

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Query:  QVSLLNQEVIIERIQSAVDSKLRSSNDMRTFQEQDVESSAACQMVISNDYAQNSSQSGPKSQKVPVHKMVRTDSTDPAGRLHAYVQMKPPGLPESSLTAV
        +VSLLNQEVIIERIQSAV+SKLRSSNDMR FQ QDVESS ACQMV+SND  QNS QSG KS KVPVHKMVRTDSTDPAGRLHAYVQMKPPGLPES+LTAV
Subjt:  QVSLLNQEVIIERIQSAVDSKLRSSNDMRTFQEQDVESSAACQMVISNDYAQNSSQSGPKSQKVPVHKMVRTDSTDPAGRLHAYVQMKPPGLPESSLTAV

Query:  R
        R
Subjt:  R

XP_038884722.1 DNA mismatch repair protein MLH1-like isoform X3 [Benincasa hispida]

3.2e-38

88.12

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Query:  QVSLLNQEVIIERIQSAVDSKLRSSNDMRTFQEQDVESSAACQMVISNDYAQNSSQSGPKSQKVPVHKMVRTDSTDPAGRLHAYVQMKPPGLPESSLTAV
        +VSLLNQEVIIERIQSAV+SKLRSSNDMR FQ QDVESS ACQMV+SND  QNS QSG KS KVPVHKMVRTDSTDPAGRLHAYVQMKPPGLPES+LTAV
Subjt:  QVSLLNQEVIIERIQSAVDSKLRSSNDMRTFQEQDVESSAACQMVISNDYAQNSSQSGPKSQKVPVHKMVRTDSTDPAGRLHAYVQMKPPGLPESSLTAV

Query:  R
        R
Subjt:  R

TrEMBL top hits

e value

%identity

Alignment

A0A5A7SWS0 DNA mismatch repair protein MLH1 isoform X2

3.8e-37

82.08

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Query:  QVSLLNQEVIIERIQSAVDSKLRSSNDMRTFQEQDVESSAACQMVISNDYAQNSSQSGPKSQKVPVHKMVRTDSTDPAGRLHAYVQMKPPGLPESSLTAV
        +VSLLNQEVIIERIQSAV+SKLRSSND + +QEQDVESS A QMV+SND  QNSS+SG KSQKVPVHKMVR DSTDPAGRLHAYVQMK PGLPESSL AV
Subjt:  QVSLLNQEVIIERIQSAVDSKLRSSNDMRTFQEQDVESSAACQMVISNDYAQNSSQSGPKSQKVPVHKMVRTDSTDPAGRLHAYVQMKPPGLPESSLTAV

Query:  RYVFPL
        RY F +
Subjt:  RYVFPL

A0A6J1E2L8 DNA mismatch repair protein MLH1

1.3e-40

92.08

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Query:  QVSLLNQEVIIERIQSAVDSKLRSSNDMRTFQEQDVESSAACQMVISNDYAQNSSQSGPKSQKVPVHKMVRTDSTDPAGRLHAYVQMKPPGLPESSLTAV
        +V+LLNQEVIIERIQSAV+SKLRSSND RTFQEQDVESSAA QMV+SNDY QNSSQSG KSQKVPVHKMVRTDSTDPAGRLHAYVQMKPPGLPESSLTAV
Subjt:  QVSLLNQEVIIERIQSAVDSKLRSSNDMRTFQEQDVESSAACQMVISNDYAQNSSQSGPKSQKVPVHKMVRTDSTDPAGRLHAYVQMKPPGLPESSLTAV

Query:  R
        R
Subjt:  R

A0A6J1EVP8 DNA mismatch repair protein MLH1 isoform X3

5.9e-38

88.12

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Query:  QVSLLNQEVIIERIQSAVDSKLRSSNDMRTFQEQDVESSAACQMVISNDYAQNSSQSGPKSQKVPVHKMVRTDSTDPAGRLHAYVQMKPPGLPESSLTAV
        +VSLLNQEVIIERIQSAV+SKLRSSND RTFQEQDVESSAA QMVI +DY QNSSQSG KSQKVPV KMVRTDSTDPAGRLHAYVQM PPGLPESSL  V
Subjt:  QVSLLNQEVIIERIQSAVDSKLRSSNDMRTFQEQDVESSAACQMVISNDYAQNSSQSGPKSQKVPVHKMVRTDSTDPAGRLHAYVQMKPPGLPESSLTAV

Query:  R
        R
Subjt:  R

A0A6J1IBD7 DNA mismatch repair protein MLH1 isoform X1

2.2e-37

86.54

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Query:  QVSLLNQEVIIERIQSAVDSKLRSSNDMRTFQEQDVESSAACQMVISNDYAQNSSQS---GPKSQKVPVHKMVRTDSTDPAGRLHAYVQMKPPGLPESSL
        +VSLLNQEVIIERIQSAV+SKLRSSND RTFQEQDVESSAA QMVIS+DY QNSSQS   G KSQK+PV KMVRTDSTDPAGRLHAYVQMKPPGLPESSL
Subjt:  QVSLLNQEVIIERIQSAVDSKLRSSNDMRTFQEQDVESSAACQMVISNDYAQNSSQS---GPKSQKVPVHKMVRTDSTDPAGRLHAYVQMKPPGLPESSL

Query:  TAVR
          VR
Subjt:  TAVR

A0A6J1ICV0 DNA mismatch repair protein MLH1 isoform X2

5.3e-39

89.11

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Query:  QVSLLNQEVIIERIQSAVDSKLRSSNDMRTFQEQDVESSAACQMVISNDYAQNSSQSGPKSQKVPVHKMVRTDSTDPAGRLHAYVQMKPPGLPESSLTAV
        +VSLLNQEVIIERIQSAV+SKLRSSND RTFQEQDVESSAA QMVIS+DY QNSSQSG KSQK+PV KMVRTDSTDPAGRLHAYVQMKPPGLPESSL  V
Subjt:  QVSLLNQEVIIERIQSAVDSKLRSSNDMRTFQEQDVESSAACQMVISNDYAQNSSQSGPKSQKVPVHKMVRTDSTDPAGRLHAYVQMKPPGLPESSLTAV

Query:  R
        R
Subjt:  R

SwissProt top hits

e value

%identity

Alignment

Q9ZRV4 DNA mismatch repair protein MLH1

2.0e-22

59.22

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Query:  QVSLLNQEVIIERIQSAVDSKLRSSNDMRTFQEQDVESSAACQMVISNDYAQNSSQSGPKSQKVPVHKMVRTDSTDPAGRLHAYVQMKPPGLPE--SSLT
        +VSLLNQE+IIE IQS V+ KLR++ND RTFQEQ VE   +      +D   +   SG K+QKVPV+KMVRTDS+DPAGRLHA++Q KP  LP+  SSL+
Subjt:  QVSLLNQEVIIERIQSAVDSKLRSSNDMRTFQEQDVESSAACQMVISNDYAQNSSQSGPKSQKVPVHKMVRTDSTDPAGRLHAYVQMKPPGLPE--SSLT

Query:  AVR
         VR
Subjt:  AVR

Arabidopsis top hits

e value

%identity

Alignment

AT4G09140.1 MUTL-homologue 1

1.4e-23

59.22

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Query:  QVSLLNQEVIIERIQSAVDSKLRSSNDMRTFQEQDVESSAACQMVISNDYAQNSSQSGPKSQKVPVHKMVRTDSTDPAGRLHAYVQMKPPGLPE--SSLT
        +VSLLNQE+IIE IQS V+ KLR++ND RTFQEQ VE   +      +D   +   SG K+QKVPV+KMVRTDS+DPAGRLHA++Q KP  LP+  SSL+
Subjt:  QVSLLNQEVIIERIQSAVDSKLRSSNDMRTFQEQDVESSAACQMVISNDYAQNSSQSGPKSQKVPVHKMVRTDSTDPAGRLHAYVQMKPPGLPE--SSLT

Query:  AVR
         VR
Subjt:  AVR

Sequences

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CDS sequence

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ATGCAGGTAAGCCTCCTGAACCAGGAAGTTATTATTGAGAGGATACAGTCAGCGGTTGATTCCAAATTAAGAAGTTCTAATGACATGAGGACATTTCAAGAACAGGATGT
AGAATCTTCTGCGGCTTGTCAAATGGTTATTAGCAATGACTATGCTCAGAATTCCTCGCAGTCTGGGCCAAAATCACAAAAGGTTCCAGTGCATAAAATGGTTAGGACAG
ATTCAACAGATCCAGCTGGAAGGTTGCACGCATATGTGCAAATGAAACCTCCTGGCCTCCCTGAATCTAGCTTGACTGCTGTGAGGTATGTATTTCCCTTAGATTTAAGC
ACGGAGCTATCAATGATTCAATATCAAAGTGTTGCGTTGAGACTCTGA

mRNA sequence

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Protein sequence

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MQVSLLNQEVIIERIQSAVDSKLRSSNDMRTFQEQDVESSAACQMVISNDYAQNSSQSGPKSQKVPVHKMVRTDSTDPAGRLHAYVQMKPPGLPESSLTAVRYVFPLDLS
TELSMIQYQSVALRL

Lag0039101 (gene) of Sponge gourd (AG-4) v1 genome