; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; CuGenDBv2

Lag0041382 (gene) of Sponge gourd (AG-4) v1 genome

Gene IDLag0041382
OrganismLuffa acutangula AG-4 (Sponge gourd (AG-4) v1)
DescriptionCCHC-type domain-containing protein
Genome locationchr13:16902912..16904305
RNA-Seq ExpressionLag0041382
SyntenyLag0041382
Gene Ontology termsGO:0003676 - nucleic acid binding (molecular function)
GO:0003824 - catalytic activity (molecular function)
GO:0008270 - zinc ion binding (molecular function)
InterPro domainsIPR001878 - Zinc finger, CCHC-type
IPR025836 - Zinc knuckle CX2CX4HX4C
IPR040256 - Uncharacterized protein At4g02000-like


Homology Show/hide homology
GenBank top hitse value%identityAlignment
OMP03234.1 hypothetical protein COLO4_10561 [Corchorus olitorius]5.3e-3332.93Show/hide
Query:  EDLVSKWRSWKLMEEEAEK--VKQGEVAPTLSEGSRELCVVGKVLSSKHVNMDAFRNVMRAAWRTHGATRIEVAGDNLFAVQFRSKGEKDA---------
        E L + W ++ L +EE  +  V    VA +L+EG  +LC++GK+LS + VN+D  RNV+   W+  G  ++   G+ L+  QF S+ EK+          
Subjt:  EDLVSKWRSWKLMEEEAEK--VKQGEVAPTLSEGSRELCVVGKVLSSKHVNMDAFRNVMRAAWRTHGATRIEVAGDNLFAVQFRSKGEKDA---------

Query:  ----------QSVSSVLDVEFKDCSFWVQIHNVPMRWQTKGMAKHLGGKIGVIEEVGGAQGSEWTGPVLRLRVCLRVDRPLLRGFHMQDEEGKEFWCRVL
                   +  SV +++ + C+FW+Q+H++P+ + T+ + K +G   G + E+         G  LR+R CL V++PL RG  +    G +      
Subjt:  ----------QSVSSVLDVEFKDCSFWVQIHNVPMRWQTKGMAKHLGGKIGVIEEVGGAQGSEWTGPVLRLRVCLRVDRPLLRGFHMQDEEGKEFWCRVL

Query:  YERLPDFCYECGCLGHSRREC--GAVGEGSSEQGEAQYGEWLRAGV
        YE+LPDFCY CGCL H+  EC    +    S + + +YG WLRA V
Subjt:  YERLPDFCYECGCLGHSRREC--GAVGEGSSEQGEAQYGEWLRAGV

XP_006485824.1 uncharacterized protein LOC102613298 [Citrus sinensis]3.8e-3132.5Show/hide
Query:  EDLVSKWRSWKLMEEEAEKVKQGEVAPTLSEGSRELCVVGKVLSSKHVNMDAFRNVMRAAWRTHGATRIEVAGDNLFAVQFRSKGEK-------------
        E+L+ K  +  L  EE   +  G       E     C+VGK+L ++ V  +  R  M+ AWRT   T++E  GDN+F  +F SK EK             
Subjt:  EDLVSKWRSWKLMEEEAEKVKQGEVAPTLSEGSRELCVVGKVLSSKHVNMDAFRNVMRAAWRTHGATRIEVAGDNLFAVQFRSKGEK-------------

Query:  ------DAQSVSSVLDVEFKDCSFWVQIHNVPMRWQTKGMAKHLGGKIGVIEEVGGAQGSEWTGPVLRLRVCLRVDRPLLRGFHMQDEEGKEFWCRVLYE
              +   +  V   +F    FWVQIHN+P+    K + + +GG+IG ++EV      E  G  +R+R+ + V RPL +   ++ E+G +   R+ YE
Subjt:  ------DAQSVSSVLDVEFKDCSFWVQIHNVPMRWQTKGMAKHLGGKIGVIEEVGGAQGSEWTGPVLRLRVCLRVDRPLLRGFHMQDEEGKEFWCRVLYE

Query:  RLPDFCYECGCLGHSRRECGAVGEGSSEQGEAQYGEWLRA
        +LPDFC+ CG +GH  REC  +      + +  YG W+RA
Subjt:  RLPDFCYECGCLGHSRRECGAVGEGSSEQGEAQYGEWLRA

XP_015388532.1 uncharacterized protein LOC107178176 [Citrus sinensis]5.4e-3029.74Show/hide
Query:  EDLVSKWRSWKLMEEEAEKVKQGEVAPTLSEGSRELCVVGKVLSSKHVNMDAFRNVMRAAWRTHGATRIEVAGDNLFAVQFRSKGEK-------------
        E+L+ K  +  L  EE   +  G       E     C+VGK+L ++ V  +  R  M+ AWRT   T++E  GDN+F  +F SK EK             
Subjt:  EDLVSKWRSWKLMEEEAEKVKQGEVAPTLSEGSRELCVVGKVLSSKHVNMDAFRNVMRAAWRTHGATRIEVAGDNLFAVQFRSKGEK-------------

Query:  ------DAQSVSSVLDVEFKDCSFWVQIHNVPMRWQTKGMAKHLGGKIGVIEEVGGAQGSEWTGPVLRLRVCLRVDRPLLRGFHMQDEEGKEFWCRVLYE
              +   +  V   +F    FWVQIHN+P+    K + + +GG+IG ++EV      E  G  +R+R+ + V  PL +   ++ E+G +   R+ YE
Subjt:  ------DAQSVSSVLDVEFKDCSFWVQIHNVPMRWQTKGMAKHLGGKIGVIEEVGGAQGSEWTGPVLRLRVCLRVDRPLLRGFHMQDEEGKEFWCRVLYE

Query:  RLPDFCYECGCLGHSRRECGAVGEGSSEQGEAQYGEWLRAGVSFSEGSRRVQEEKVEGGVNQSVGVPAT
        +LPDFC+ CG +GH  REC  +      + +  YG W+RA            +++  G    S   P +
Subjt:  RLPDFCYECGCLGHSRRECGAVGEGSSEQGEAQYGEWLRAGVSFSEGSRRVQEEKVEGGVNQSVGVPAT

XP_022149484.1 uncharacterized protein LOC111017902 [Momordica charantia]1.3e-4436.15Show/hide
Query:  MEDLVSKWRSWKLMEEEAEKVKQGEVAPTLSEGSRELCVVGKVLSSKHVNMDAFRNVMRAAWRTHGATRIEVAGDNLFAVQFRSKGEK------------
        M+++   W  +K   +E E V      P L+  + +LCVV K+ +SK ++ +A R+VM++ WR H +TR E  G N++ + F+S  EK            
Subjt:  MEDLVSKWRSWKLMEEEAEKVKQGEVAPTLSEGSRELCVVGKVLSSKHVNMDAFRNVMRAAWRTHGATRIEVAGDNLFAVQFRSKGEK------------

Query:  -------DAQSVSSVLDVEFKDCSFWVQIHNVPMRWQTKGMAKHLGGKIGVIEEVGGAQGSEWTGPVLRLRVCLRVDRPLLRGFHMQDEEGKEFWCRVLY
                  + +  LD+ F  C+FW+QIHN+P    +  MA  LG K+G +EE+ G     W GP +R+RV + V +PL RG  +++ +GK+ WC + Y
Subjt:  -------DAQSVSSVLDVEFKDCSFWVQIHNVPMRWQTKGMAKHLGGKIGVIEEVGGAQGSEWTGPVLRLRVCLRVDRPLLRGFHMQDEEGKEFWCRVLY

Query:  ERLPDFCYECGCLGHSRRECGAVGEGSSEQGEAQYGEWLRAGVSFSEGSRRVQEEKVEGG
        E+LPDFCYECG +GHS REC    +  +     QYG+WLRA +     S   +E    GG
Subjt:  ERLPDFCYECGCLGHSRRECGAVGEGSSEQGEAQYGEWLRAGVSFSEGSRRVQEEKVEGG

XP_022156711.1 uncharacterized protein LOC111023555 [Momordica charantia]1.8e-4137.9Show/hide
Query:  MEDLVSKWRSWKLMEEEAEKVKQGEVAPTLSEGSRELCVVGKVLSSKHVNMDAFRNVMRAAWRTHGATRIEVAGDNLFAVQFRSKGEK------------
        M+D+   W ++ L++EE + +      P L+  + +LC VGK+  SK + ++AF +VM+  W+ H +TRIE AG N++ + F++  EK            
Subjt:  MEDLVSKWRSWKLMEEEAEKVKQGEVAPTLSEGSRELCVVGKVLSSKHVNMDAFRNVMRAAWRTHGATRIEVAGDNLFAVQFRSKGEK------------

Query:  -------DAQSVSSVLDVEFKDCSFWVQIHNVPMRWQTKGMAKHLGGKIGVIEEVGGAQGSEWTGPVLRLRVCLRVDRPLLRGFHMQDEEGKEFWCRVLY
                  + +  LD++   C+FWVQIH +     TK MAK LG ++G +EEV G    +W  P L +RV + V +PL RG  ++  +GK+ WC + Y
Subjt:  -------DAQSVSSVLDVEFKDCSFWVQIHNVPMRWQTKGMAKHLGGKIGVIEEVGGAQGSEWTGPVLRLRVCLRVDRPLLRGFHMQDEEGKEFWCRVLY

Query:  ERLPDFCYECGCLGHSRRE
        ERLPDFCY CGC+GHS RE
Subjt:  ERLPDFCYECGCLGHSRRE

TrEMBL top hitse value%identityAlignment
A0A1R3GTB5 Reverse transcriptase7.7e-3031.88Show/hide
Query:  EDLVSKWRSWKLMEEEAEKVKQGE--VAPTLSEGSRELCVVGKVLSSKHVNMDAFRNVMRAAWRTHGATRIEVAGDNLFAVQFRSKGEKDA---------
        E L   W ++ L EEE  +V      V  TL+EG+   C++GK+LS + VN++  RNVM   W+  G  ++   G+NLF  QF S  EK+          
Subjt:  EDLVSKWRSWKLMEEEAEKVKQGE--VAPTLSEGSRELCVVGKVLSSKHVNMDAFRNVMRAAWRTHGATRIEVAGDNLFAVQFRSKGEKDA---------

Query:  ----------QSVSSVLDVEFKDCSFWVQIHNVPMRWQTKGMAKHLGGKIGVIEEVGGAQGSEWTGPVLRLRVCLRVDRPLLRGFHMQDEEGKEFWCRVL
                   +   V D++   CSFW Q H++P+ +  + + + +G   G +EE+         G  LR R  L V +PL RG  +    G +      
Subjt:  ----------QSVSSVLDVEFKDCSFWVQIHNVPMRWQTKGMAKHLGGKIGVIEEVGGAQGSEWTGPVLRLRVCLRVDRPLLRGFHMQDEEGKEFWCRVL

Query:  YERLPDFCYECGCLGHSRRECGAVGEGSSEQGE--AQYGEWLRAGVSFSEG----------SRRVQEEKVEGGVNQ
        YE+LPDFCY CGCL H   EC        ++G+   +YG WLRA V  S+           +R  +EE+ +  VN+
Subjt:  YERLPDFCYECGCLGHSRRECGAVGEGSSEQGE--AQYGEWLRAGVSFSEG----------SRRVQEEKVEGGVNQ

A0A1R3K847 Uncharacterized protein2.5e-3332.93Show/hide
Query:  EDLVSKWRSWKLMEEEAEK--VKQGEVAPTLSEGSRELCVVGKVLSSKHVNMDAFRNVMRAAWRTHGATRIEVAGDNLFAVQFRSKGEKDA---------
        E L + W ++ L +EE  +  V    VA +L+EG  +LC++GK+LS + VN+D  RNV+   W+  G  ++   G+ L+  QF S+ EK+          
Subjt:  EDLVSKWRSWKLMEEEAEK--VKQGEVAPTLSEGSRELCVVGKVLSSKHVNMDAFRNVMRAAWRTHGATRIEVAGDNLFAVQFRSKGEKDA---------

Query:  ----------QSVSSVLDVEFKDCSFWVQIHNVPMRWQTKGMAKHLGGKIGVIEEVGGAQGSEWTGPVLRLRVCLRVDRPLLRGFHMQDEEGKEFWCRVL
                   +  SV +++ + C+FW+Q+H++P+ + T+ + K +G   G + E+         G  LR+R CL V++PL RG  +    G +      
Subjt:  ----------QSVSSVLDVEFKDCSFWVQIHNVPMRWQTKGMAKHLGGKIGVIEEVGGAQGSEWTGPVLRLRVCLRVDRPLLRGFHMQDEEGKEFWCRVL

Query:  YERLPDFCYECGCLGHSRREC--GAVGEGSSEQGEAQYGEWLRAGV
        YE+LPDFCY CGCL H+  EC    +    S + + +YG WLRA V
Subjt:  YERLPDFCYECGCLGHSRREC--GAVGEGSSEQGEAQYGEWLRAGV

A0A2N9E6P9 CCHC-type domain-containing protein2.6e-3031.97Show/hide
Query:  EDLVSKWRSWKLMEEEAE--KVKQGEVAPTLSEGSRELCVVGKVLSSKHVNMDAFRNVMRAAWRTHGATRIEVAGDNLFAVQFRSKGEK-----------
        E+LV +WR + L E+E     V++  +  +L +GS   C++GK+++ K  N  A ++ M   W     TR ++ GDNLF  QF+ + E+           
Subjt:  EDLVSKWRSWKLMEEEAE--KVKQGEVAPTLSEGSRELCVVGKVLSSKHVNMDAFRNVMRAAWRTHGATRIEVAGDNLFAVQFRSKGEK-----------

Query:  --------DAQSVSSVLDVEFKDCSFWVQIHNVPMRWQTKGMAKHLGGKIGVIEEVGGAQGSEWTGPVLRLRVCLRVDRPLLRGFHMQDEEGKEFWCRVL
                +         ++F  C FWVQ+H +P+ + TK   + LG  +G + +V   +G    GP LR+R+CL   +P+ RG  +  +   + W    
Subjt:  --------DAQSVSSVLDVEFKDCSFWVQIHNVPMRWQTKGMAKHLGGKIGVIEEVGGAQGSEWTGPVLRLRVCLRVDRPLLRGFHMQDEEGKEFWCRVL

Query:  YERLPDFCYECGCLGHSRRECGAVGEGSSEQG--EAQYGEWLRA
        YERLP  C+ CG LGHS R+C A      +      QYG WLRA
Subjt:  YERLPDFCYECGCLGHSRRECGAVGEGSSEQG--EAQYGEWLRA

A0A6J1D765 uncharacterized protein LOC1110179026.5e-4536.15Show/hide
Query:  MEDLVSKWRSWKLMEEEAEKVKQGEVAPTLSEGSRELCVVGKVLSSKHVNMDAFRNVMRAAWRTHGATRIEVAGDNLFAVQFRSKGEK------------
        M+++   W  +K   +E E V      P L+  + +LCVV K+ +SK ++ +A R+VM++ WR H +TR E  G N++ + F+S  EK            
Subjt:  MEDLVSKWRSWKLMEEEAEKVKQGEVAPTLSEGSRELCVVGKVLSSKHVNMDAFRNVMRAAWRTHGATRIEVAGDNLFAVQFRSKGEK------------

Query:  -------DAQSVSSVLDVEFKDCSFWVQIHNVPMRWQTKGMAKHLGGKIGVIEEVGGAQGSEWTGPVLRLRVCLRVDRPLLRGFHMQDEEGKEFWCRVLY
                  + +  LD+ F  C+FW+QIHN+P    +  MA  LG K+G +EE+ G     W GP +R+RV + V +PL RG  +++ +GK+ WC + Y
Subjt:  -------DAQSVSSVLDVEFKDCSFWVQIHNVPMRWQTKGMAKHLGGKIGVIEEVGGAQGSEWTGPVLRLRVCLRVDRPLLRGFHMQDEEGKEFWCRVLY

Query:  ERLPDFCYECGCLGHSRRECGAVGEGSSEQGEAQYGEWLRAGVSFSEGSRRVQEEKVEGG
        E+LPDFCYECG +GHS REC    +  +     QYG+WLRA +     S   +E    GG
Subjt:  ERLPDFCYECGCLGHSRRECGAVGEGSSEQGEAQYGEWLRAGVSFSEGSRRVQEEKVEGG

A0A6J1DVS4 uncharacterized protein LOC1110235558.7e-4237.9Show/hide
Query:  MEDLVSKWRSWKLMEEEAEKVKQGEVAPTLSEGSRELCVVGKVLSSKHVNMDAFRNVMRAAWRTHGATRIEVAGDNLFAVQFRSKGEK------------
        M+D+   W ++ L++EE + +      P L+  + +LC VGK+  SK + ++AF +VM+  W+ H +TRIE AG N++ + F++  EK            
Subjt:  MEDLVSKWRSWKLMEEEAEKVKQGEVAPTLSEGSRELCVVGKVLSSKHVNMDAFRNVMRAAWRTHGATRIEVAGDNLFAVQFRSKGEK------------

Query:  -------DAQSVSSVLDVEFKDCSFWVQIHNVPMRWQTKGMAKHLGGKIGVIEEVGGAQGSEWTGPVLRLRVCLRVDRPLLRGFHMQDEEGKEFWCRVLY
                  + +  LD++   C+FWVQIH +     TK MAK LG ++G +EEV G    +W  P L +RV + V +PL RG  ++  +GK+ WC + Y
Subjt:  -------DAQSVSSVLDVEFKDCSFWVQIHNVPMRWQTKGMAKHLGGKIGVIEEVGGAQGSEWTGPVLRLRVCLRVDRPLLRGFHMQDEEGKEFWCRVLY

Query:  ERLPDFCYECGCLGHSRRE
        ERLPDFCY CGC+GHS RE
Subjt:  ERLPDFCYECGCLGHSRRE

SwissProt top hitse value%identityAlignment
No hits found
Arabidopsis top hitse value%identityAlignment
AT3G42140.1 zinc ion binding;nucleic acid binding8.4e-0526.85Show/hide
Query:  DVEFKDCSFWVQIHNVPMRWQTKGMAKHLGGKIGVIEEVGGAQGSEWTGPVLRLRVCLRVDRPLLRGFHMQDEEGKEFWCRVLYERLPDFCYECGCLGHS
        D EFK   FW+QI  +P+R+ T  +   +G ++G+  E                   L  D  +L               +  YE+L +FC  CG L H 
Subjt:  DVEFKDCSFWVQIHNVPMRWQTKGMAKHLGGKIGVIEEVGGAQGSEWTGPVLRLRVCLRVDRPLLRGFHMQDEEGKEFWCRVLYERLPDFCYECGCLGHS

Query:  RRECGAVG
          EC   G
Subjt:  RRECGAVG


Sequences Show/hide sequences
CDS sequenceShow/hide CDS sequence
ATGCAGGCGGTGGGGGTGCTGTTTTGTGGTCGGGCTTCGAGGTTGTTTCAGGCGGTGGTTTGTTTTCGGTGGTGTTTGGTGTTTTTTGTGTTGCCGCTCGATAGTCTGTT
CTGGCGGCGCTCCGTATTGGTTTGGGCTCGTTCAATCTATGAGATGACAGGCGGAACTGGTGGAAGTGGAACAAGAGGTTTGTGGGGTGGTTTTTGGGGCAGGAGGGCGA
TGGAGGATTTGGTGAGTAAGTGGAGGTCCTGGAAGTTGATGGAGGAGGAAGCAGAGAAGGTGAAGCAGGGGGAGGTGGCGCCGACCTTATCTGAGGGATCGAGAGAGCTT
TGTGTGGTGGGGAAGGTGCTCTCGTCGAAGCATGTGAATATGGATGCTTTTCGAAATGTGATGAGAGCGGCATGGAGAACCCATGGGGCGACTCGGATAGAAGTGGCGGG
GGACAATTTGTTTGCTGTCCAGTTTCGGTCTAAAGGGGAAAAGGATGCACAATCGGTTTCGTCAGTTCTAGATGTGGAGTTCAAGGACTGCTCCTTCTGGGTTCAGATTC
ACAATGTTCCCATGCGTTGGCAGACAAAGGGGATGGCGAAGCATCTAGGAGGGAAGATTGGTGTTATAGAGGAGGTAGGTGGGGCGCAAGGGAGCGAGTGGACAGGACCT
GTATTAAGGTTGAGAGTGTGCCTGAGGGTGGATCGGCCTCTGCTAAGAGGTTTCCATATGCAGGATGAGGAGGGTAAGGAATTCTGGTGTCGAGTGTTGTATGAACGGTT
GCCGGATTTCTGTTATGAGTGTGGCTGCTTGGGTCACTCAAGGAGGGAGTGTGGGGCGGTGGGGGAAGGTTCTTCAGAGCAGGGAGAGGCGCAGTATGGGGAGTGGTTGC
GGGCGGGGGTGAGTTTCAGTGAGGGTAGTCGGAGGGTCCAGGAGGAGAAGGTGGAGGGGGGAGTGAATCAGAGTGTCGGGGTTCCGGCGACGCCTGTTGGAGGGGGTGCG
CAAGTTCCGGCCCCTGAGAGGGAGGGGGTGAGAGTGGTGGGGGAGGGAGGAGAGGTTCTGGAGACGCGTGCTGGTGAAGCTAGTTCTGAAGTGGCTCCCTAG
mRNA sequenceShow/hide mRNA sequence
ATGCAGGCGGTGGGGGTGCTGTTTTGTGGTCGGGCTTCGAGGTTGTTTCAGGCGGTGGTTTGTTTTCGGTGGTGTTTGGTGTTTTTTGTGTTGCCGCTCGATAGTCTGTT
CTGGCGGCGCTCCGTATTGGTTTGGGCTCGTTCAATCTATGAGATGACAGGCGGAACTGGTGGAAGTGGAACAAGAGGTTTGTGGGGTGGTTTTTGGGGCAGGAGGGCGA
TGGAGGATTTGGTGAGTAAGTGGAGGTCCTGGAAGTTGATGGAGGAGGAAGCAGAGAAGGTGAAGCAGGGGGAGGTGGCGCCGACCTTATCTGAGGGATCGAGAGAGCTT
TGTGTGGTGGGGAAGGTGCTCTCGTCGAAGCATGTGAATATGGATGCTTTTCGAAATGTGATGAGAGCGGCATGGAGAACCCATGGGGCGACTCGGATAGAAGTGGCGGG
GGACAATTTGTTTGCTGTCCAGTTTCGGTCTAAAGGGGAAAAGGATGCACAATCGGTTTCGTCAGTTCTAGATGTGGAGTTCAAGGACTGCTCCTTCTGGGTTCAGATTC
ACAATGTTCCCATGCGTTGGCAGACAAAGGGGATGGCGAAGCATCTAGGAGGGAAGATTGGTGTTATAGAGGAGGTAGGTGGGGCGCAAGGGAGCGAGTGGACAGGACCT
GTATTAAGGTTGAGAGTGTGCCTGAGGGTGGATCGGCCTCTGCTAAGAGGTTTCCATATGCAGGATGAGGAGGGTAAGGAATTCTGGTGTCGAGTGTTGTATGAACGGTT
GCCGGATTTCTGTTATGAGTGTGGCTGCTTGGGTCACTCAAGGAGGGAGTGTGGGGCGGTGGGGGAAGGTTCTTCAGAGCAGGGAGAGGCGCAGTATGGGGAGTGGTTGC
GGGCGGGGGTGAGTTTCAGTGAGGGTAGTCGGAGGGTCCAGGAGGAGAAGGTGGAGGGGGGAGTGAATCAGAGTGTCGGGGTTCCGGCGACGCCTGTTGGAGGGGGTGCG
CAAGTTCCGGCCCCTGAGAGGGAGGGGGTGAGAGTGGTGGGGGAGGGAGGAGAGGTTCTGGAGACGCGTGCTGGTGAAGCTAGTTCTGAAGTGGCTCCCTAG
Protein sequenceShow/hide protein sequence
MQAVGVLFCGRASRLFQAVVCFRWCLVFFVLPLDSLFWRRSVLVWARSIYEMTGGTGGSGTRGLWGGFWGRRAMEDLVSKWRSWKLMEEEAEKVKQGEVAPTLSEGSREL
CVVGKVLSSKHVNMDAFRNVMRAAWRTHGATRIEVAGDNLFAVQFRSKGEKDAQSVSSVLDVEFKDCSFWVQIHNVPMRWQTKGMAKHLGGKIGVIEEVGGAQGSEWTGP
VLRLRVCLRVDRPLLRGFHMQDEEGKEFWCRVLYERLPDFCYECGCLGHSRRECGAVGEGSSEQGEAQYGEWLRAGVSFSEGSRRVQEEKVEGGVNQSVGVPATPVGGGA
QVPAPEREGVRVVGEGGEVLETRAGEASSEVAP