; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; CuGenDBv2

Lsi03G015410 (gene) of Bottle gourd (USVL1VR-Ls) v1 genome

Gene IDLsi03G015410
OrganismLagenaria siceraria USVL1VR-Ls (Bottle gourd (USVL1VR-Ls) v1)
DescriptionHydroxymethylglutaryl-CoA lyase
Genome locationchr03:26426100..26428547
RNA-Seq ExpressionLsi03G015410
SyntenyLsi03G015410
Gene Ontology termsGO:0006552 - leucine catabolic process (biological process)
GO:0006629 - lipid metabolic process (biological process)
GO:0046951 - ketone body biosynthetic process (biological process)
GO:0004419 - hydroxymethylglutaryl-CoA lyase activity (molecular function)
InterPro domainsIPR000891 - Pyruvate carboxyltransferase
IPR013785 - Aldolase-type TIM barrel
IPR043594 - HMG-CoA lyase


Homology Show/hide homology
GenBank top hitse value%identityAlignment
KAE8651197.1 hypothetical protein Csa_002494 [Cucumis sativus]1.2e-5070.83Show/hide
Query:  VIPMLESVVNVVPIENLAVHFHDTYGQALSNILISLQVISSFHLGFNCSEPTTTSPQKIYANELSPYLSYATLHLARILMGIGTVDSSVSGLGGCPYAKG
        VIPMLESV NVVP ENLAVHFHDTYGQALSNIL+SLQ                                          MGIGTVDSSVSGLGGCPYAKG
Subjt:  VIPMLESVVNVVPIENLAVHFHDTYGQALSNILISLQVISSFHLGFNCSEPTTTSPQKIYANELSPYLSYATLHLARILMGIGTVDSSVSGLGGCPYAKG

Query:  ASGNVATEDVVYMLNGIGVKTNVDLEKLMLAGDFICKHLGRPSASKVAIALRKVASNANKCTATASKL
        ASGNVATEDVVYMLNGIG KTNVDL KLMLAGDFICK LGRPSASKVAIALRKVASN NKCTATASKL
Subjt:  ASGNVATEDVVYMLNGIGVKTNVDLEKLMLAGDFICKHLGRPSASKVAIALRKVASNANKCTATASKL

XP_008443338.1 PREDICTED: hydroxymethylglutaryl-CoA lyase, mitochondrial-like [Cucumis melo]2.6e-5372.62Show/hide
Query:  VIPMLESVVNVVPIENLAVHFHDTYGQALSNILISLQVISSFHLGFNCSEPTTTSPQKIYANELSPYLSYATLHLARILMGIGTVDSSVSGLGGCPYAKG
        VIPMLESV+NVVPIENLAVHFHDTYGQALSNIL+SLQ                                          MGIGTVDSSVSGLGGCPYAKG
Subjt:  VIPMLESVVNVVPIENLAVHFHDTYGQALSNILISLQVISSFHLGFNCSEPTTTSPQKIYANELSPYLSYATLHLARILMGIGTVDSSVSGLGGCPYAKG

Query:  ASGNVATEDVVYMLNGIGVKTNVDLEKLMLAGDFICKHLGRPSASKVAIALRKVASNANKCTATASKL
        ASGNVATEDVVYMLNGIG KTNVDLEKLMLAGDFICKHLGRPSASKVAIALRKV SNANKCTATASKL
Subjt:  ASGNVATEDVVYMLNGIGVKTNVDLEKLMLAGDFICKHLGRPSASKVAIALRKVASNANKCTATASKL

XP_011652210.1 hydroxymethylglutaryl-CoA lyase, mitochondrial [Cucumis sativus]1.2e-5070.83Show/hide
Query:  VIPMLESVVNVVPIENLAVHFHDTYGQALSNILISLQVISSFHLGFNCSEPTTTSPQKIYANELSPYLSYATLHLARILMGIGTVDSSVSGLGGCPYAKG
        VIPMLESV NVVP ENLAVHFHDTYGQALSNIL+SLQ                                          MGIGTVDSSVSGLGGCPYAKG
Subjt:  VIPMLESVVNVVPIENLAVHFHDTYGQALSNILISLQVISSFHLGFNCSEPTTTSPQKIYANELSPYLSYATLHLARILMGIGTVDSSVSGLGGCPYAKG

Query:  ASGNVATEDVVYMLNGIGVKTNVDLEKLMLAGDFICKHLGRPSASKVAIALRKVASNANKCTATASKL
        ASGNVATEDVVYMLNGIG KTNVDL KLMLAGDFICK LGRPSASKVAIALRKVASN NKCTATASKL
Subjt:  ASGNVATEDVVYMLNGIGVKTNVDLEKLMLAGDFICKHLGRPSASKVAIALRKVASNANKCTATASKL

XP_023526452.1 hydroxymethylglutaryl-CoA lyase, mitochondrial-like isoform X2 [Cucurbita pepo subsp. pepo]3.5e-5070.83Show/hide
Query:  VIPMLESVVNVVPIENLAVHFHDTYGQALSNILISLQVISSFHLGFNCSEPTTTSPQKIYANELSPYLSYATLHLARILMGIGTVDSSVSGLGGCPYAKG
        VIPMLESVV+VVPIENLAVHFHDTYGQALSNIL+SLQ                                          MGIGTVD SVSGLGGCPYAKG
Subjt:  VIPMLESVVNVVPIENLAVHFHDTYGQALSNILISLQVISSFHLGFNCSEPTTTSPQKIYANELSPYLSYATLHLARILMGIGTVDSSVSGLGGCPYAKG

Query:  ASGNVATEDVVYMLNGIGVKTNVDLEKLMLAGDFICKHLGRPSASKVAIALRKVASNANKCTATASKL
        ASGNVATEDVVYMLNGIGVKTNVDLEKLMLAGDFI KHLGRPSASKVAIAL+KVAS  NKCTATASKL
Subjt:  ASGNVATEDVVYMLNGIGVKTNVDLEKLMLAGDFICKHLGRPSASKVAIALRKVASNANKCTATASKL

XP_038905646.1 hydroxymethylglutaryl-CoA lyase, mitochondrial-like [Benincasa hispida]8.8e-5473.81Show/hide
Query:  VIPMLESVVNVVPIENLAVHFHDTYGQALSNILISLQVISSFHLGFNCSEPTTTSPQKIYANELSPYLSYATLHLARILMGIGTVDSSVSGLGGCPYAKG
        VIPMLESVVNVVPIENLAVHFHDTYGQALSNIL+SLQ                                          MGIGTVDSSVSGLGGCPYAKG
Subjt:  VIPMLESVVNVVPIENLAVHFHDTYGQALSNILISLQVISSFHLGFNCSEPTTTSPQKIYANELSPYLSYATLHLARILMGIGTVDSSVSGLGGCPYAKG

Query:  ASGNVATEDVVYMLNGIGVKTNVDLEKLMLAGDFICKHLGRPSASKVAIALRKVASNANKCTATASKL
        ASGNVATEDVVYMLNGIGVKT+VDLEKLMLAGDFICKHLGRPSASKVAIALRKVASNANKCTATASKL
Subjt:  ASGNVATEDVVYMLNGIGVKTNVDLEKLMLAGDFICKHLGRPSASKVAIALRKVASNANKCTATASKL

TrEMBL top hitse value%identityAlignment
A0A0A0LHM6 Hydroxymethylglutaryl-CoA lyase5.8e-5170.83Show/hide
Query:  VIPMLESVVNVVPIENLAVHFHDTYGQALSNILISLQVISSFHLGFNCSEPTTTSPQKIYANELSPYLSYATLHLARILMGIGTVDSSVSGLGGCPYAKG
        VIPMLESV NVVP ENLAVHFHDTYGQALSNIL+SLQ                                          MGIGTVDSSVSGLGGCPYAKG
Subjt:  VIPMLESVVNVVPIENLAVHFHDTYGQALSNILISLQVISSFHLGFNCSEPTTTSPQKIYANELSPYLSYATLHLARILMGIGTVDSSVSGLGGCPYAKG

Query:  ASGNVATEDVVYMLNGIGVKTNVDLEKLMLAGDFICKHLGRPSASKVAIALRKVASNANKCTATASKL
        ASGNVATEDVVYMLNGIG KTNVDL KLMLAGDFICK LGRPSASKVAIALRKVASN NKCTATASKL
Subjt:  ASGNVATEDVVYMLNGIGVKTNVDLEKLMLAGDFICKHLGRPSASKVAIALRKVASNANKCTATASKL

A0A1S3B7B2 Hydroxymethylglutaryl-CoA lyase1.2e-5372.62Show/hide
Query:  VIPMLESVVNVVPIENLAVHFHDTYGQALSNILISLQVISSFHLGFNCSEPTTTSPQKIYANELSPYLSYATLHLARILMGIGTVDSSVSGLGGCPYAKG
        VIPMLESV+NVVPIENLAVHFHDTYGQALSNIL+SLQ                                          MGIGTVDSSVSGLGGCPYAKG
Subjt:  VIPMLESVVNVVPIENLAVHFHDTYGQALSNILISLQVISSFHLGFNCSEPTTTSPQKIYANELSPYLSYATLHLARILMGIGTVDSSVSGLGGCPYAKG

Query:  ASGNVATEDVVYMLNGIGVKTNVDLEKLMLAGDFICKHLGRPSASKVAIALRKVASNANKCTATASKL
        ASGNVATEDVVYMLNGIG KTNVDLEKLMLAGDFICKHLGRPSASKVAIALRKV SNANKCTATASKL
Subjt:  ASGNVATEDVVYMLNGIGVKTNVDLEKLMLAGDFICKHLGRPSASKVAIALRKVASNANKCTATASKL

A0A5A7UJY0 Hydroxymethylglutaryl-CoA lyase1.2e-5372.62Show/hide
Query:  VIPMLESVVNVVPIENLAVHFHDTYGQALSNILISLQVISSFHLGFNCSEPTTTSPQKIYANELSPYLSYATLHLARILMGIGTVDSSVSGLGGCPYAKG
        VIPMLESV+NVVPIENLAVHFHDTYGQALSNIL+SLQ                                          MGIGTVDSSVSGLGGCPYAKG
Subjt:  VIPMLESVVNVVPIENLAVHFHDTYGQALSNILISLQVISSFHLGFNCSEPTTTSPQKIYANELSPYLSYATLHLARILMGIGTVDSSVSGLGGCPYAKG

Query:  ASGNVATEDVVYMLNGIGVKTNVDLEKLMLAGDFICKHLGRPSASKVAIALRKVASNANKCTATASKL
        ASGNVATEDVVYMLNGIG KTNVDLEKLMLAGDFICKHLGRPSASKVAIALRKV SNANKCTATASKL
Subjt:  ASGNVATEDVVYMLNGIGVKTNVDLEKLMLAGDFICKHLGRPSASKVAIALRKVASNANKCTATASKL

A0A6J1J6X5 Hydroxymethylglutaryl-CoA lyase1.7e-5070.83Show/hide
Query:  VIPMLESVVNVVPIENLAVHFHDTYGQALSNILISLQVISSFHLGFNCSEPTTTSPQKIYANELSPYLSYATLHLARILMGIGTVDSSVSGLGGCPYAKG
        VIPMLESVV+VVPIENLAVHFHDTYGQALSNIL+SLQ                                          MGIGTVD SVSGLGGCPYAKG
Subjt:  VIPMLESVVNVVPIENLAVHFHDTYGQALSNILISLQVISSFHLGFNCSEPTTTSPQKIYANELSPYLSYATLHLARILMGIGTVDSSVSGLGGCPYAKG

Query:  ASGNVATEDVVYMLNGIGVKTNVDLEKLMLAGDFICKHLGRPSASKVAIALRKVASNANKCTATASKL
        ASGNVATEDVVYMLNGIGVKTNVDLEKLMLAGDFI KHLGRPSASKVAIAL+KVAS  NKCTATASKL
Subjt:  ASGNVATEDVVYMLNGIGVKTNVDLEKLMLAGDFICKHLGRPSASKVAIALRKVASNANKCTATASKL

A0A6J1J8Q9 Hydroxymethylglutaryl-CoA lyase1.7e-5070.83Show/hide
Query:  VIPMLESVVNVVPIENLAVHFHDTYGQALSNILISLQVISSFHLGFNCSEPTTTSPQKIYANELSPYLSYATLHLARILMGIGTVDSSVSGLGGCPYAKG
        VIPMLESVV+VVPIENLAVHFHDTYGQALSNIL+SLQ                                          MGIGTVD SVSGLGGCPYAKG
Subjt:  VIPMLESVVNVVPIENLAVHFHDTYGQALSNILISLQVISSFHLGFNCSEPTTTSPQKIYANELSPYLSYATLHLARILMGIGTVDSSVSGLGGCPYAKG

Query:  ASGNVATEDVVYMLNGIGVKTNVDLEKLMLAGDFICKHLGRPSASKVAIALRKVASNANKCTATASKL
        ASGNVATEDVVYMLNGIGVKTNVDLEKLMLAGDFI KHLGRPSASKVAIAL+KVAS  NKCTATASKL
Subjt:  ASGNVATEDVVYMLNGIGVKTNVDLEKLMLAGDFICKHLGRPSASKVAIALRKVASNANKCTATASKL

SwissProt top hitse value%identityAlignment
D4A5C3 3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic1.0e-2850.34Show/hide
Query:  MLESVVNVVPIENLAVHFHDTYGQALSNILISLQVISSFHLGFNCSEPTTTSPQKIYANELSPYLSYATLHLARILMGIGTVDSSVSGLGGCPYAKGASG
        MLESV+  +P   LAVH HDTYGQAL+NIL +LQ                                          MGI  VDS+VSGLGGCPYAKGASG
Subjt:  MLESVVNVVPIENLAVHFHDTYGQALSNILISLQVISSFHLGFNCSEPTTTSPQKIYANELSPYLSYATLHLARILMGIGTVDSSVSGLGGCPYAKGASG

Query:  NVATEDVVYMLNGIGVKTNVDLEKLMLAGDFICKHLGRPSASKVAIA
        NVATED++YMLNG+G+ T VDL K+M AGDFICK + + + SKVA A
Subjt:  NVATEDVVYMLNGIGVKTNVDLEKLMLAGDFICKHLGRPSASKVAIA

O81027 Hydroxymethylglutaryl-CoA lyase, mitochondrial1.9e-3854.94Show/hide
Query:  AVIPMLESVVNVVPIENLAVHFHDTYGQALSNILISLQVISSFHLGFNCSEPTTTSPQKIYANELSPYLSYATLHLARILMGIGTVDSSVSGLGGCPYAK
        +V+PMLE+V+ VVP + LAVHFHDTYGQAL+NIL+SLQ                                          MGI  VDSS++GLGGCPYAK
Subjt:  AVIPMLESVVNVVPIENLAVHFHDTYGQALSNILISLQVISSFHLGFNCSEPTTTSPQKIYANELSPYLSYATLHLARILMGIGTVDSSVSGLGGCPYAK

Query:  GASGNVATEDVVYMLNGIGVKTNVDLEKLMLAGDFICKHLGRPSASKVAIAL-RKVASNANK
        GASGNVATEDVVYMLNG+GV TNVDL KL+ AGDFI KHLGRP+ SK A+AL R++ ++A+K
Subjt:  GASGNVATEDVVYMLNGIGVKTNVDLEKLMLAGDFICKHLGRPSASKVAIAL-RKVASNANK

P38060 Hydroxymethylglutaryl-CoA lyase, mitochondrial7.8e-2947.68Show/hide
Query:  MLESVVNVVPIENLAVHFHDTYGQALSNILISLQVISSFHLGFNCSEPTTTSPQKIYANELSPYLSYATLHLARILMGIGTVDSSVSGLGGCPYAKGASG
        ML +V++ VP+  LAVH HDTYGQAL+N L++LQ                                          MG+  VDSSV+GLGGCPYAKGASG
Subjt:  MLESVVNVVPIENLAVHFHDTYGQALSNILISLQVISSFHLGFNCSEPTTTSPQKIYANELSPYLSYATLHLARILMGIGTVDSSVSGLGGCPYAKGASG

Query:  NVATEDVVYMLNGIGVKTNVDLEKLMLAGDFICKHLGRPSASKVAIALRKV
        N+ATED+VYMLNG+G+ T V+L+KL+ AGDFIC+ L R ++SKVA A  K+
Subjt:  NVATEDVVYMLNGIGVKTNVDLEKLMLAGDFICKHLGRPSASKVAIALRKV

P97519 Hydroxymethylglutaryl-CoA lyase, mitochondrial3.9e-2847.02Show/hide
Query:  MLESVVNVVPIENLAVHFHDTYGQALSNILISLQVISSFHLGFNCSEPTTTSPQKIYANELSPYLSYATLHLARILMGIGTVDSSVSGLGGCPYAKGASG
        ML +V++ VP+  LAVH HDTYGQAL+N L++LQ                                          MG+  VDSSV+GLGGCPYAKGASG
Subjt:  MLESVVNVVPIENLAVHFHDTYGQALSNILISLQVISSFHLGFNCSEPTTTSPQKIYANELSPYLSYATLHLARILMGIGTVDSSVSGLGGCPYAKGASG

Query:  NVATEDVVYMLNGIGVKTNVDLEKLMLAGDFICKHLGRPSASKVAIALRKV
        N+ATED+VYML G+G+ T V+L+KL+ AGDFIC+ L R ++SKVA A  K+
Subjt:  NVATEDVVYMLNGIGVKTNVDLEKLMLAGDFICKHLGRPSASKVAIALRKV

Q8TB92 3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic5.1e-2849.66Show/hide
Query:  MLESVVNVVPIENLAVHFHDTYGQALSNILISLQVISSFHLGFNCSEPTTTSPQKIYANELSPYLSYATLHLARILMGIGTVDSSVSGLGGCPYAKGASG
        MLESV+  +P   LAVH HDTYGQAL+NIL +LQ                                          MGI  VDS+VSGLGGCPYAKGASG
Subjt:  MLESVVNVVPIENLAVHFHDTYGQALSNILISLQVISSFHLGFNCSEPTTTSPQKIYANELSPYLSYATLHLARILMGIGTVDSSVSGLGGCPYAKGASG

Query:  NVATEDVVYMLNGIGVKTNVDLEKLMLAGDFICKHLGRPSASKVAIA
        NVATED++YMLNG+G+ T V+L K+M AGDFICK + + + SKVA A
Subjt:  NVATEDVVYMLNGIGVKTNVDLEKLMLAGDFICKHLGRPSASKVAIA

Arabidopsis top hitse value%identityAlignment
AT2G26800.1 Aldolase superfamily protein1.3e-3954.94Show/hide
Query:  AVIPMLESVVNVVPIENLAVHFHDTYGQALSNILISLQVISSFHLGFNCSEPTTTSPQKIYANELSPYLSYATLHLARILMGIGTVDSSVSGLGGCPYAK
        +V+PMLE+V+ VVP + LAVHFHDTYGQAL+NIL+SLQ                                          MGI  VDSS++GLGGCPYAK
Subjt:  AVIPMLESVVNVVPIENLAVHFHDTYGQALSNILISLQVISSFHLGFNCSEPTTTSPQKIYANELSPYLSYATLHLARILMGIGTVDSSVSGLGGCPYAK

Query:  GASGNVATEDVVYMLNGIGVKTNVDLEKLMLAGDFICKHLGRPSASKVAIAL-RKVASNANK
        GASGNVATEDVVYMLNG+GV TNVDL KL+ AGDFI KHLGRP+ SK A+AL R++ ++A+K
Subjt:  GASGNVATEDVVYMLNGIGVKTNVDLEKLMLAGDFICKHLGRPSASKVAIAL-RKVASNANK

AT2G26800.2 Aldolase superfamily protein1.3e-3954.94Show/hide
Query:  AVIPMLESVVNVVPIENLAVHFHDTYGQALSNILISLQVISSFHLGFNCSEPTTTSPQKIYANELSPYLSYATLHLARILMGIGTVDSSVSGLGGCPYAK
        +V+PMLE+V+ VVP + LAVHFHDTYGQAL+NIL+SLQ                                          MGI  VDSS++GLGGCPYAK
Subjt:  AVIPMLESVVNVVPIENLAVHFHDTYGQALSNILISLQVISSFHLGFNCSEPTTTSPQKIYANELSPYLSYATLHLARILMGIGTVDSSVSGLGGCPYAK

Query:  GASGNVATEDVVYMLNGIGVKTNVDLEKLMLAGDFICKHLGRPSASKVAIAL-RKVASNANK
        GASGNVATEDVVYMLNG+GV TNVDL KL+ AGDFI KHLGRP+ SK A+AL R++ ++A+K
Subjt:  GASGNVATEDVVYMLNGIGVKTNVDLEKLMLAGDFICKHLGRPSASKVAIAL-RKVASNANK


Sequences Show/hide sequences
CDS sequenceShow/hide CDS sequence
ATGGTAAGAGTCTGGGACGATCATCTTTTAAGCATTTTTCTGTACTTTGCTCAGCGAGTGAGGTCAGGAGGGGCTGTCGAATCTCCATGGCTTATATTGCATCGAGCTGT
GATTCCAATGCTTGAATCTGTAGTTAATGTTGTTCCAATTGAAAATCTTGCTGTTCATTTCCATGACACTTACGGGCAAGCTCTGTCCAATATCCTGATCTCACTCCAGG
TAATCTCTTCTTTCCATCTTGGTTTTAATTGCTCGGAACCTACAACTACGAGTCCTCAAAAAATATATGCCAATGAGTTGAGTCCTTATCTCTCGTACGCTACCTTGCAC
TTAGCAAGAATCCTTATGGGGATTGGCACGGTTGATTCTTCGGTTTCGGGTCTTGGGGGTTGTCCATATGCTAAAGGTGCTTCTGGAAACGTTGCAACTGAAGATGTTGT
GTATATGCTGAATGGAATTGGGGTGAAGACCAATGTAGATCTTGAAAAGCTCATGTTGGCTGGAGATTTCATCTGCAAGCACTTGGGGCGTCCTTCCGCTTCAAAAGTAG
CAATTGCATTGCGGAAAGTTGCCTCCAACGCCAATAAATGCACAGCTACTGCATCCAAATTATGA
mRNA sequenceShow/hide mRNA sequence
ATGGTAAGAGTCTGGGACGATCATCTTTTAAGCATTTTTCTGTACTTTGCTCAGCGAGTGAGGTCAGGAGGGGCTGTCGAATCTCCATGGCTTATATTGCATCGAGCTGT
GATTCCAATGCTTGAATCTGTAGTTAATGTTGTTCCAATTGAAAATCTTGCTGTTCATTTCCATGACACTTACGGGCAAGCTCTGTCCAATATCCTGATCTCACTCCAGG
TAATCTCTTCTTTCCATCTTGGTTTTAATTGCTCGGAACCTACAACTACGAGTCCTCAAAAAATATATGCCAATGAGTTGAGTCCTTATCTCTCGTACGCTACCTTGCAC
TTAGCAAGAATCCTTATGGGGATTGGCACGGTTGATTCTTCGGTTTCGGGTCTTGGGGGTTGTCCATATGCTAAAGGTGCTTCTGGAAACGTTGCAACTGAAGATGTTGT
GTATATGCTGAATGGAATTGGGGTGAAGACCAATGTAGATCTTGAAAAGCTCATGTTGGCTGGAGATTTCATCTGCAAGCACTTGGGGCGTCCTTCCGCTTCAAAAGTAG
CAATTGCATTGCGGAAAGTTGCCTCCAACGCCAATAAATGCACAGCTACTGCATCCAAATTATGAGAATTAAGTATTGAAGAGATACAATCTTGATGGCAAGAGGACATA
TGAAGAAATAATGGAGTCGGTTTAAGTTGGTCCATTTTAGTCATTGAATTTTTTGAACATCTATTTGTTATCTTTGAACTTGTAGAAAGTAACTATTTTGGTCCTCGTTT
TTATGTTTATTTTTACACATTAATGACGTAGTTTGAGAATTTGTACTAACTTATTAATATGAATATGATTTCAAGTCACATGTACACGGACCAAAATGATTATTTTTGAA
AAGTTGAAGAATTAATAGATATTTTGAAAGTTTTGAG
Protein sequenceShow/hide protein sequence
MVRVWDDHLLSIFLYFAQRVRSGGAVESPWLILHRAVIPMLESVVNVVPIENLAVHFHDTYGQALSNILISLQVISSFHLGFNCSEPTTTSPQKIYANELSPYLSYATLH
LARILMGIGTVDSSVSGLGGCPYAKGASGNVATEDVVYMLNGIGVKTNVDLEKLMLAGDFICKHLGRPSASKVAIALRKVASNANKCTATASKL