CuGenDBv2

Gene ID	Lsi03G016850
Organism	Lagenaria siceraria USVL1VR-Ls (Bottle gourd (USVL1VR-Ls) v1)
Description	DNA topoisomerase
Genome location	chr03:28111781..28120130
RNA-Seq Expression	Lsi03G016850
Synteny	Lsi03G016850
Gene Ontology terms	GO:0006265 - DNA topological change (biological process) GO:0005634 - nucleus (cellular component) GO:0005694 - chromosome (cellular component) GO:0003677 - DNA binding (molecular function) GO:0008270 - zinc ion binding (molecular function) GO:0003917 - DNA topoisomerase type I activity (molecular function)
InterPro domains	IPR003602 - DNA topoisomerase, type IA, DNA-binding domain IPR034144 - DNA topoisomerase 3-like, TOPRIM domain IPR023406 - DNA topoisomerase, type IA, active site IPR023405 - DNA topoisomerase, type IA, core domain IPR013826 - DNA topoisomerase, type IA, central region, subdomain 3 IPR013825 - DNA topoisomerase, type IA, central region, subdomain 2 IPR013824 - DNA topoisomerase, type IA, central region, subdomain 1 IPR013497 - DNA topoisomerase, type IA, central IPR006171 - TOPRIM domain IPR003601 - DNA topoisomerase, type IA, domain 2 IPR000380 - DNA topoisomerase, type IA

Homology

Show/hide homology

GenBank top hits

e value

%identity

Alignment

KAG6580840.1 Insulin-degrading enzyme-like 1, peroxisomal, partial [Cucurbita argyrosperma subsp. sororia]

7.1e-251

84.21

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Query:  MSSGRPITVLNVAEKPSVAKSVATILSRNQGLRVREGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELDFEERYRKWHSCDPVQLFHAPIRKFVPEDK
        M+ GRPITVLNVAEKPSVAKSVATILSRNQGLRVREGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMEL+FEERYRKWHSCDPV+LF+AP+RK VPEDK
Subjt:  MSSGRPITVLNVAEKPSVAKSVATILSRNQGLRVREGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELDFEERYRKWHSCDPVQLFHAPIRKFVPEDK

Query:  MDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTTANHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLL
        MDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTT N HLNIKRAHFSALIERDIHEAVQNLVQPNK+FADAVDARQEIDLRIGASFTRFQTMLL
Subjt:  MDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTTANHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLL

Query:  KDAFNIDSVADDKNIVLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMCIQESTAT------------
        KDAFNIDSV DD+N+VLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNS DGISTFSWTRGNLFDYTCAVV YEMC++ESTAT            
Subjt:  KDAFNIDSVADDKNIVLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMCIQESTAT------------

Query:  ---------------------------VAEDLYQAGFISYPRTETDCFSQRTDLH-----------------------VGLWRNPSGGGHDDKAHPPIHP
                                   VAEDLYQAGFISYPRTETDCFSQRTDLH                        GLWRNPSGGGHDDKAHPPIHP
Subjt:  ---------------------------VAEDLYQAGFISYPRTETDCFSQRTDLH-----------------------VGLWRNPSGGGHDDKAHPPIHP

Query:  TKFSAGERGWSQDHHRLYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGVTRPPP
        TKFSAGERGWSQDHHRLYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILARNYLDVYRFESWGGSTIPTY SGQQFVPTTLTLDSGVTRPPP
Subjt:  TKFSAGERGWSQDHHRLYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGVTRPPP

Query:  LLSEADLLSCMDK
        LLSEADLLSCMDK
Subjt:  LLSEADLLSCMDK

XP_008443145.1 PREDICTED: DNA topoisomerase 3-alpha isoform X1 [Cucumis melo]

2.2e-252

84.6

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Query:  MSSGRPITVLNVAEKPSVAKSVATILSRNQGLRVREGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELDFEERYRKWHSCDPVQLFHAPIRKFVPEDK
        MS GRPITVLNVAEKPSVAKSVATILSRNQGLRVR+GRSRYNKIFEFNYAIRGQSCNM+VTSVTGHLMEL FEERYRKW+SCDPVQLFHAP+ KFVPEDK
Subjt:  MSSGRPITVLNVAEKPSVAKSVATILSRNQGLRVREGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELDFEERYRKWHSCDPVQLFHAPIRKFVPEDK

Query:  MDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTTANHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLL
        +DIKRTLEQEARR QWLVLWLDCDREGENIAFEVVEVCT  NHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQT+LL
Subjt:  MDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTTANHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLL

Query:  KDAFNIDSVADDKNIVLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMCIQESTAT------------
        KDAFNIDSV DD+NIVLSYGPCQFPTLGFVVERYWEIQ+HEPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMC+QESTAT            
Subjt:  KDAFNIDSVADDKNIVLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMCIQESTAT------------

Query:  ---------------------------VAEDLYQAGFISYPRTETDCFSQRTDLH-----------------------VGLWRNPSGGGHDDKAHPPIHP
                                   VAEDLYQAGFISYPRTETDCFSQRTDLH                        GLWRNPSGGGHDDKAHPPIHP
Subjt:  ---------------------------VAEDLYQAGFISYPRTETDCFSQRTDLH-----------------------VGLWRNPSGGGHDDKAHPPIHP

Query:  TKFSAGERGWSQDHHRLYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGVTRPPP
        TKFSAGERGWSQDHHRLYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGVTRPPP
Subjt:  TKFSAGERGWSQDHHRLYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGVTRPPP

Query:  LLSEADLLSCMDK
        LLSEADLLSCMDK
Subjt:  LLSEADLLSCMDK

XP_011652135.2 DNA topoisomerase 3-alpha isoform X1 [Cucumis sativus]

5.4e-251

84.21

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Query:  MSSGRPITVLNVAEKPSVAKSVATILSRNQGLRVREGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELDFEERYRKWHSCDPVQLFHAPIRKFVPEDK
        MS GR ITVLNVAEKPSVAKSVATILSRNQGLRVR+GRSRYNKIFEFNYAIRGQSCNM+VTSVTGHLMEL FEERYRKWHSCDPVQLFHAP+ KFVPEDK
Subjt:  MSSGRPITVLNVAEKPSVAKSVATILSRNQGLRVREGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELDFEERYRKWHSCDPVQLFHAPIRKFVPEDK

Query:  MDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTTANHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLL
        +DIKRTLEQE+RR QWLVLWLDCDREGENIAFEVVEVCT  NHHLNIKRAHFSALIERDIH+AVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQT+LL
Subjt:  MDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTTANHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLL

Query:  KDAFNIDSVADDKNIVLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMCIQESTAT------------
        KDAFNIDSV DD+NIVLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMC+QESTAT            
Subjt:  KDAFNIDSVADDKNIVLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMCIQESTAT------------

Query:  ---------------------------VAEDLYQAGFISYPRTETDCFSQRTDLH-----------------------VGLWRNPSGGGHDDKAHPPIHP
                                   VAEDLYQAGFISYPRTETDCFSQRTDLH                         LWRNPSGGGHDDKAHPPIHP
Subjt:  ---------------------------VAEDLYQAGFISYPRTETDCFSQRTDLH-----------------------VGLWRNPSGGGHDDKAHPPIHP

Query:  TKFSAGERGWSQDHHRLYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGVTRPPP
        TKFSAGERGWSQDHHRLYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGVTRPPP
Subjt:  TKFSAGERGWSQDHHRLYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGVTRPPP

Query:  LLSEADLLSCMDK
        LLSEADLLSCMDK
Subjt:  LLSEADLLSCMDK

XP_016899727.1 PREDICTED: DNA topoisomerase 3-alpha isoform X2 [Cucumis melo]

2.2e-252

84.6

Show/hide

Query:  MSSGRPITVLNVAEKPSVAKSVATILSRNQGLRVREGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELDFEERYRKWHSCDPVQLFHAPIRKFVPEDK
        MS GRPITVLNVAEKPSVAKSVATILSRNQGLRVR+GRSRYNKIFEFNYAIRGQSCNM+VTSVTGHLMEL FEERYRKW+SCDPVQLFHAP+ KFVPEDK
Subjt:  MSSGRPITVLNVAEKPSVAKSVATILSRNQGLRVREGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELDFEERYRKWHSCDPVQLFHAPIRKFVPEDK

Query:  MDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTTANHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLL
        +DIKRTLEQEARR QWLVLWLDCDREGENIAFEVVEVCT  NHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQT+LL
Subjt:  MDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTTANHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLL

Query:  KDAFNIDSVADDKNIVLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMCIQESTAT------------
        KDAFNIDSV DD+NIVLSYGPCQFPTLGFVVERYWEIQ+HEPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMC+QESTAT            
Subjt:  KDAFNIDSVADDKNIVLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMCIQESTAT------------

Query:  ---------------------------VAEDLYQAGFISYPRTETDCFSQRTDLH-----------------------VGLWRNPSGGGHDDKAHPPIHP
                                   VAEDLYQAGFISYPRTETDCFSQRTDLH                        GLWRNPSGGGHDDKAHPPIHP
Subjt:  ---------------------------VAEDLYQAGFISYPRTETDCFSQRTDLH-----------------------VGLWRNPSGGGHDDKAHPPIHP

Query:  TKFSAGERGWSQDHHRLYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGVTRPPP
        TKFSAGERGWSQDHHRLYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGVTRPPP
Subjt:  TKFSAGERGWSQDHHRLYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGVTRPPP

Query:  LLSEADLLSCMDK
        LLSEADLLSCMDK
Subjt:  LLSEADLLSCMDK

XP_038904101.1 DNA topoisomerase 3-alpha isoform X1 [Benincasa hispida]

4.4e-253

84.8

Show/hide

Query:  MSSGRPITVLNVAEKPSVAKSVATILSRNQGLRVREGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELDFEERYRKWHSCDPVQLFHAPIRKFVPEDK
        MS GRPITVLNVAEKPSVAKSVATILSRNQGLRVR+GRSRYNKIFEFNYAIRGQSCNM+VTSVTGHLMEL+FEERYRKWHSCDPVQLFHAP+RK VPEDK
Subjt:  MSSGRPITVLNVAEKPSVAKSVATILSRNQGLRVREGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELDFEERYRKWHSCDPVQLFHAPIRKFVPEDK

Query:  MDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTTANHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLL
        MDIKRTLEQEARRCQWL+LWLDCDREGENIAFEVVEVCT  N HLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLL
Subjt:  MDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTTANHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLL

Query:  KDAFNIDSVADDKNIVLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMCIQESTAT------------
        KDAFNIDSV DD+NIVLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNS DGISTFSWTRGNLFDYTCAVVFYEMC+QE TAT            
Subjt:  KDAFNIDSVADDKNIVLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMCIQESTAT------------

Query:  ---------------------------VAEDLYQAGFISYPRTETDCFSQRTDLH-----------------------VGLWRNPSGGGHDDKAHPPIHP
                                   VAEDLYQAGFISYPRTETDCFSQRTDLH                        GLWRNPSGGGHDDKAHPPIHP
Subjt:  ---------------------------VAEDLYQAGFISYPRTETDCFSQRTDLH-----------------------VGLWRNPSGGGHDDKAHPPIHP

Query:  TKFSAGERGWSQDHHRLYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGVTRPPP
        TKFSAGERGWSQDHHRLYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGVTRPPP
Subjt:  TKFSAGERGWSQDHHRLYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGVTRPPP

Query:  LLSEADLLSCMDK
        LLSEADLLSCMDK
Subjt:  LLSEADLLSCMDK

TrEMBL top hits

e value

%identity

Alignment

A0A0A0LBG7 DNA topoisomerase

2.6e-251

84.21

Show/hide

Query:  MSSGRPITVLNVAEKPSVAKSVATILSRNQGLRVREGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELDFEERYRKWHSCDPVQLFHAPIRKFVPEDK
        MS GR ITVLNVAEKPSVAKSVATILSRNQGLRVR+GRSRYNKIFEFNYAIRGQSCNM+VTSVTGHLMEL FEERYRKWHSCDPVQLFHAP+ KFVPEDK
Subjt:  MSSGRPITVLNVAEKPSVAKSVATILSRNQGLRVREGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELDFEERYRKWHSCDPVQLFHAPIRKFVPEDK

Query:  MDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTTANHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLL
        +DIKRTLEQE+RR QWLVLWLDCDREGENIAFEVVEVCT  NHHLNIKRAHFSALIERDIH+AVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQT+LL
Subjt:  MDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTTANHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLL

Query:  KDAFNIDSVADDKNIVLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMCIQESTAT------------
        KDAFNIDSV DD+NIVLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMC+QESTAT            
Subjt:  KDAFNIDSVADDKNIVLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMCIQESTAT------------

Query:  ---------------------------VAEDLYQAGFISYPRTETDCFSQRTDLH-----------------------VGLWRNPSGGGHDDKAHPPIHP
                                   VAEDLYQAGFISYPRTETDCFSQRTDLH                         LWRNPSGGGHDDKAHPPIHP
Subjt:  ---------------------------VAEDLYQAGFISYPRTETDCFSQRTDLH-----------------------VGLWRNPSGGGHDDKAHPPIHP

Query:  TKFSAGERGWSQDHHRLYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGVTRPPP
        TKFSAGERGWSQDHHRLYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGVTRPPP
Subjt:  TKFSAGERGWSQDHHRLYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGVTRPPP

Query:  LLSEADLLSCMDK
        LLSEADLLSCMDK
Subjt:  LLSEADLLSCMDK

A0A1S3B7B9 DNA topoisomerase

1.1e-252

84.6

Show/hide

Query:  MSSGRPITVLNVAEKPSVAKSVATILSRNQGLRVREGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELDFEERYRKWHSCDPVQLFHAPIRKFVPEDK
        MS GRPITVLNVAEKPSVAKSVATILSRNQGLRVR+GRSRYNKIFEFNYAIRGQSCNM+VTSVTGHLMEL FEERYRKW+SCDPVQLFHAP+ KFVPEDK
Subjt:  MSSGRPITVLNVAEKPSVAKSVATILSRNQGLRVREGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELDFEERYRKWHSCDPVQLFHAPIRKFVPEDK

Query:  MDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTTANHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLL
        +DIKRTLEQEARR QWLVLWLDCDREGENIAFEVVEVCT  NHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQT+LL
Subjt:  MDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTTANHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLL

Query:  KDAFNIDSVADDKNIVLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMCIQESTAT------------
        KDAFNIDSV DD+NIVLSYGPCQFPTLGFVVERYWEIQ+HEPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMC+QESTAT            
Subjt:  KDAFNIDSVADDKNIVLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMCIQESTAT------------

Query:  ---------------------------VAEDLYQAGFISYPRTETDCFSQRTDLH-----------------------VGLWRNPSGGGHDDKAHPPIHP
                                   VAEDLYQAGFISYPRTETDCFSQRTDLH                        GLWRNPSGGGHDDKAHPPIHP
Subjt:  ---------------------------VAEDLYQAGFISYPRTETDCFSQRTDLH-----------------------VGLWRNPSGGGHDDKAHPPIHP

Query:  TKFSAGERGWSQDHHRLYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGVTRPPP
        TKFSAGERGWSQDHHRLYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGVTRPPP
Subjt:  TKFSAGERGWSQDHHRLYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGVTRPPP

Query:  LLSEADLLSCMDK
        LLSEADLLSCMDK
Subjt:  LLSEADLLSCMDK

A0A1S4DUQ9 DNA topoisomerase

1.1e-252

84.6

Show/hide

Query:  MSSGRPITVLNVAEKPSVAKSVATILSRNQGLRVREGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELDFEERYRKWHSCDPVQLFHAPIRKFVPEDK
        MS GRPITVLNVAEKPSVAKSVATILSRNQGLRVR+GRSRYNKIFEFNYAIRGQSCNM+VTSVTGHLMEL FEERYRKW+SCDPVQLFHAP+ KFVPEDK
Subjt:  MSSGRPITVLNVAEKPSVAKSVATILSRNQGLRVREGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELDFEERYRKWHSCDPVQLFHAPIRKFVPEDK

Query:  MDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTTANHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLL
        +DIKRTLEQEARR QWLVLWLDCDREGENIAFEVVEVCT  NHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQT+LL
Subjt:  MDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTTANHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLL

Query:  KDAFNIDSVADDKNIVLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMCIQESTAT------------
        KDAFNIDSV DD+NIVLSYGPCQFPTLGFVVERYWEIQ+HEPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMC+QESTAT            
Subjt:  KDAFNIDSVADDKNIVLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMCIQESTAT------------

Query:  ---------------------------VAEDLYQAGFISYPRTETDCFSQRTDLH-----------------------VGLWRNPSGGGHDDKAHPPIHP
                                   VAEDLYQAGFISYPRTETDCFSQRTDLH                        GLWRNPSGGGHDDKAHPPIHP
Subjt:  ---------------------------VAEDLYQAGFISYPRTETDCFSQRTDLH-----------------------VGLWRNPSGGGHDDKAHPPIHP

Query:  TKFSAGERGWSQDHHRLYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGVTRPPP
        TKFSAGERGWSQDHHRLYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGVTRPPP
Subjt:  TKFSAGERGWSQDHHRLYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGVTRPPP

Query:  LLSEADLLSCMDK
        LLSEADLLSCMDK
Subjt:  LLSEADLLSCMDK

A0A6J1F0T9 DNA topoisomerase

3.2e-249

83.63

Show/hide

Query:  MSSGRPITVLNVAEKPSVAKSVATILSRNQGLRVREGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELDFEERYRKWHSCDPVQLFHAPIRKFVPEDK
        M+ GRPITVLNVAEKPSVAKSVATILSRNQGLRVREGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMEL+FEERYRKWHSCDPV+LF+AP+RK VPEDK
Subjt:  MSSGRPITVLNVAEKPSVAKSVATILSRNQGLRVREGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELDFEERYRKWHSCDPVQLFHAPIRKFVPEDK

Query:  MDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTTANHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLL
        MDIKRTLEQEA RCQWLVLWLDCDREGENIAFEVVEVCT  N HLNIKRAHFSALIERDIHEAVQNLVQPNK++ADAVDARQEIDLRIGASFTRFQTMLL
Subjt:  MDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTTANHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLL

Query:  KDAFNIDSVADDKNIVLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMCIQESTAT------------
        KDAFNIDSV DD+N+VLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNS DGISTFSWTRGNLFDYTCAVV YEMC++ESTAT            
Subjt:  KDAFNIDSVADDKNIVLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMCIQESTAT------------

Query:  ---------------------------VAEDLYQAGFISYPRTETDCFSQRTDLH-----------------------VGLWRNPSGGGHDDKAHPPIHP
                                   VAEDLYQAGFISYPRTETDCFSQRTDLH                        GLWRNPSGGGHDDKAHPPIHP
Subjt:  ---------------------------VAEDLYQAGFISYPRTETDCFSQRTDLH-----------------------VGLWRNPSGGGHDDKAHPPIHP

Query:  TKFSAGERGWSQDHHRLYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGVTRPPP
        TKFSAGERGWSQDHHRLYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILARNYLDVYRFESWGGSTIPTY SGQQFVPTTLTLDSGVTRPPP
Subjt:  TKFSAGERGWSQDHHRLYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGVTRPPP

Query:  LLSEADLLSCMDK
        LLSEADLLSCMDK
Subjt:  LLSEADLLSCMDK

A0A6J1IXM8 DNA topoisomerase

3.4e-251

84.21

Show/hide

Query:  MSSGRPITVLNVAEKPSVAKSVATILSRNQGLRVREGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELDFEERYRKWHSCDPVQLFHAPIRKFVPEDK
        M+ GRPITVLNVAEKPSVAKSVATILSRNQGLRVREGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMEL+FEERYRKWHSCDPV+LF+AP+RK VPEDK
Subjt:  MSSGRPITVLNVAEKPSVAKSVATILSRNQGLRVREGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELDFEERYRKWHSCDPVQLFHAPIRKFVPEDK

Query:  MDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTTANHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLL
        MDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTT N HLNIKRAHFSALIERDIHEAVQNLVQPNK+FADAVDARQEIDLRIGASFTRFQTMLL
Subjt:  MDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTTANHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLL

Query:  KDAFNIDSVADDKNIVLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMCIQESTAT------------
        KDAFNIDSV DD+N+VLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNS DGISTFSWTRGNLFDYTCAVV YEMC++ESTAT            
Subjt:  KDAFNIDSVADDKNIVLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMCIQESTAT------------

Query:  ---------------------------VAEDLYQAGFISYPRTETDCFSQRTDLH-----------------------VGLWRNPSGGGHDDKAHPPIHP
                                   VAEDLYQAGFISYPRTETDCFSQRTDLH                        GLWRNPSGGGHDDKAHPPIHP
Subjt:  ---------------------------VAEDLYQAGFISYPRTETDCFSQRTDLH-----------------------VGLWRNPSGGGHDDKAHPPIHP

Query:  TKFSAGERGWSQDHHRLYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGVTRPPP
        TKFSAGERGWSQDHHRLYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILARNYLDVYRFESWGGSTIPTY SGQQFVPTTLTLDSGVTRPPP
Subjt:  TKFSAGERGWSQDHHRLYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGVTRPPP

Query:  LLSEADLLSCMDK
        LLSEADLLSCMDK
Subjt:  LLSEADLLSCMDK

SwissProt top hits

e value

%identity

Alignment

C7J0A2 DNA topoisomerase 3-alpha

3.2e-206

67.91

Show/hide

Query:  GRPITVLNVAEKPSVAKSVATILSR-NQGLRVREGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELDFEERYRKWHSCDPVQLFHAPIRKFVPEDKMD
        G  I VLNVAEKPSVAKSVA ILSR + G+R REGRSRYN++FEF+Y+I G++C+MLVTSVTGHLMEL+F++R+R+WHSCDP  LFHAP+RK VP+DK D
Subjt:  GRPITVLNVAEKPSVAKSVATILSR-NQGLRVREGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELDFEERYRKWHSCDPVQLFHAPIRKFVPEDKMD

Query:  IKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTTANHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLLKD
        IKRTLE+EAR+CQWLVLWLDCDREGENIA+EV+++C  AN  LNI RA FSALI+R+IHEAVQ+L +PNK FADAVDARQEIDLRIGASFTRFQTMLLKD
Subjt:  IKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTTANHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLLKD

Query:  AFNIDSVADDKNIVLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMCIQESTAT--------------
        AF +D   DD+NI+LSYGPCQFPTLGF+VER+WEIQ+HEPEEFWTINCSH SD+G ++F W RG+LFDY+ AVV YEMC++E  AT              
Subjt:  AFNIDSVADDKNIVLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMCIQESTAT--------------

Query:  -------------------------VAEDLYQAGFISYPRTETDCFSQRTDLH-----------------------VGLWRNPSGGGHDDKAHPPIHPTK
                                 VAE+LYQAGFISYPRTETD FS  TDLH                         LWRNPS GGHDDKAHPPIHPTK
Subjt:  -------------------------VAEDLYQAGFISYPRTETDCFSQRTDLH-----------------------VGLWRNPSGGGHDDKAHPPIHPTK

Query:  FSAGERGWSQDHHRLYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGVTRPPPLL
        FSAGE  W+ +H +LYELVVRHFLAC SQPAVGA TTVEIDIAGE F+ SGR++LA+NYLDVYRF+SWGG+ +PTY+ GQQFVPTTLTLDSG+TRPPPLL
Subjt:  FSAGERGWSQDHHRLYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGVTRPPPLL

Query:  SEADLLSCMDK
        +EADLL CMDK
Subjt:  SEADLLSCMDK

O70157 DNA topoisomerase 3-alpha

1.1e-118

44.11

Show/hide

Query:  VLNVAEKPSVAKSVATILSRNQGLRVREGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELDFEERYRKWHSCDPVQLFHAPIRKFVPEDKMDIKRTLE
        VL VAEK   AK +A +LS N  +R +EG S++NKI+EF+Y + GQ+  M++TSV+GHL+  DF+ ++RKW SC+P+ LF A I K+ PE+ +DIK+TLE
Subjt:  VLNVAEKPSVAKSVATILSRNQGLRVREGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELDFEERYRKWHSCDPVQLFHAPIRKFVPEDKMDIKRTLE

Query:  QEARRCQWLVLWLDCDREGENIAFEVVEVCTTANHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLLKDAFNIDS
        +E   CQ LV+W DCDREGENI FE++ VC     +L + RA FS +    +  A +NL +P++  +DAVD RQE+DLRIGA+FTRFQT+ L+  F  + 
Subjt:  QEARRCQWLVLWLDCDREGENIAFEVVEVCTTANHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLLKDAFNIDS

Query:  VADDKNIVLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMCIQESTATV-------------------
        +A+    ++SYG CQFPTLGFVVER+  IQ+  PE F  I  +H+  DG   F+W R  LF++T  +V Y++C+++  ATV                   
Subjt:  VADDKNIVLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMCIQESTATV-------------------

Query:  --------------------AEDLYQAGFISYPRTETDCF-----------SQRTDLHVGLWR---------NPSGGGHDDKAHPPIHPTKFSAGERGWS
                            AE LY  G+ISYPRTET+ F            Q  D H G +           P  G   D+AHPPIHPTK+++G +G  
Subjt:  --------------------AEDLYQAGFISYPRTETDCF-----------SQRTDLHVGLWR---------NPSGGGHDDKAHPPIHPTKFSAGERGWS

Query:  QDHHRLYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGVTRPPPLLSEADLLSCM
         D  RLYE +VRHFLAC SQ A G  TTVEIDIA E F   G +ILARNYLDVY ++ W    +P Y  G  F P+T+ +  G T PP LL+EADL++ M
Subjt:  QDHHRLYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGVTRPPPLLSEADLLSCM

Query:  DK--VSEMCLPTELIKFWGLNLYVGL
        +K  +       E I+     +YVGL
Subjt:  DK--VSEMCLPTELIKFWGLNLYVGL

Q13472 DNA topoisomerase 3-alpha

3.9e-119

44.49

Show/hide

Query:  VLNVAEKPSVAKSVATILSRNQGLRVREGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELDFEERYRKWHSCDPVQLFHAPIRKFVPEDKMDIKRTLE
        VL VAEK   AK +A +LS N  +R REG S++NKI+EF+Y + GQ+  M++TSV+GHL+  DF+ ++RKW SC+P+ LF A I K+ PE+ +DIK+TLE
Subjt:  VLNVAEKPSVAKSVATILSRNQGLRVREGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELDFEERYRKWHSCDPVQLFHAPIRKFVPEDKMDIKRTLE

Query:  QEARRCQWLVLWLDCDREGENIAFEVVEVCTTANHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLLKDAFNIDS
        +E R+CQ LV+W DCDREGENI FE++ VC     +L + RA FS +    +  A +NL +P++  +DAVD RQE+DLRIGA+FTRFQT+ L+  F  + 
Subjt:  QEARRCQWLVLWLDCDREGENIAFEVVEVCTTANHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLLKDAFNIDS

Query:  VADDKNIVLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMCIQESTATV-------------------
        +A+    ++SYG CQFPTLGFVVER+  IQ+  PE F  I  +H+  DGI  F+W R  LF++T  +V Y++C+++  ATV                   
Subjt:  VADDKNIVLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMCIQESTATV-------------------

Query:  --------------------AEDLYQAGFISYPRTETDCFSQRTDLHVGL--------W------------RNPSGGGHDDKAHPPIHPTKFSAGERGWS
                            AE LY  G+ISYPRTET+ F +  +L V +        W              P  G   D+AHPPIHPTK++   +G  
Subjt:  --------------------AEDLYQAGFISYPRTETDCFSQRTDLHVGL--------W------------RNPSGGGHDDKAHPPIHPTKFSAGERGWS

Query:  QDHHRLYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGVTRPPPLLSEADLLSCM
         D  RLYE +VRHFLAC SQ A G  TTVEIDIA E F   G MILARNYLDVY ++ W    +P Y  G  F P+T+ +  G T PP LL+EADL++ M
Subjt:  QDHHRLYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGVTRPPPLLSEADLLSCM

Query:  DK--VSEMCLPTELIKFWGLNLYVGL
        +K  +       E I+     +YVGL
Subjt:  DK--VSEMCLPTELIKFWGLNLYVGL

Q8T2T7 DNA topoisomerase 3

2.2e-117

45.47

Show/hide

Query:  VLNVAEKPSVAKSVATILSRNQGLRVREGRSRYNKIFEFNYAIRG-QSCNMLVTSVTGHLMELDFEERYRKWHSCDPVQLFHAPIRKFVPEDKMDIKRTL
        +LNVAEKPS AK +A ILS N+   VREG S+YNK+++F Y I     C M  TSVTGHLME+D  E+++ W SCDP+QLF APIRK VP DK  +K+TL
Subjt:  VLNVAEKPSVAKSVATILSRNQGLRVREGRSRYNKIFEFNYAIRG-QSCNMLVTSVTGHLMELDFEERYRKWHSCDPVQLFHAPIRKFVPEDKMDIKRTL

Query:  EQEARRCQWLVLWLDCDREGENIAFEVVEVCTTANHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLLKDAFNID
        E+E ++   L+LWLDCDREGENIAFEV+EVC  A       RAHFSA+I R+I  A +NL +PN+  + AVD R EIDLRIGA+FTRFQT+ LK  F I 
Subjt:  EQEARRCQWLVLWLDCDREGENIAFEVVEVCTTANHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLLKDAFNID

Query:  SVADDK---------NI------------VLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGIS------TFSWTRGNLFDYTCAVVFYEM
        S +D++         NI            ++SYGPCQFPTLGFVVERY+ I + +PE+FW ++  H   D  S      TFSW R  LFDYT A + YE 
Subjt:  SVADDK---------NI------------VLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGIS------TFSWTRGNLFDYTCAVVFYEM

Query:  CIQESTATV--------------------------------------AEDLYQAGFISYPRTETDCFSQRTDLHVGLWRN--------------------
        C+  + ATV                                      AE+LY  G ISYPRTETD F   TDL  GL  N                    
Subjt:  CIQESTATV--------------------------------------AEDLYQAGFISYPRTETDCFSQRTDLHVGLWRN--------------------

Query:  --PSGGGHDDKAHPPIHPTKFSAGERGWSQDHHRLYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILARNYLDVYRFESWGGSTIPTYVSGQ
          P  G ++D +HPPIHPT  + G  G   +  ++Y+ + R FLAC S+ +V A TTV IDI GE FS +G M+L   YL+VY F+      IPTY  G+
Subjt:  --PSGGGHDDKAHPPIHPTKFSAGERGWSQDHHRLYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILARNYLDVYRFESWGGSTIPTYVSGQ

Query:  QFVPTTLTLDSGVTRPPPLLSEADLLSCMD
        +F P  + L  G T  P  ++EA+LL+ MD
Subjt:  QFVPTTLTLDSGVTRPPPLLSEADLLSCMD

Q9LVP1 DNA topoisomerase 3-alpha

5.7e-203

67.71

Show/hide

Query:  GRPITVLNVAEKPSVAKSVATILSRNQGLRVREGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELDFEERYRKWHSCDPVQLFHAPIRKFVPEDKMDI
        G P+TVLNVAEKPSVAKSVA ILSR    R REGRSRYNKIFEF+YAI GQ C ML+TSV GHLMEL+F +RYRKWHSCDP  L+ AP+ K VPEDK DI
Subjt:  GRPITVLNVAEKPSVAKSVATILSRNQGLRVREGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELDFEERYRKWHSCDPVQLFHAPIRKFVPEDKMDI

Query:  KRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTTANHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLLKDA
        K+TLE+EAR+  WLVLWLDCDREGENIAFEVV+VC    H+L I+RAHFSALI+RDIHEAVQNL  PN+ FA+AVDARQEIDLRIGASFTRFQTMLL+D 
Subjt:  KRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTTANHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLLKDA

Query:  FNIDSVADDKNIVLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMCIQESTAT---------------
        F IDS  ++++ V+SYGPCQFPTLGF+VERYWEIQ+HEPEEFWTINCSH S++G++TF+W RG+LFDY  AV+ YEMC++E TAT               
Subjt:  FNIDSVADDKNIVLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMCIQESTAT---------------

Query:  -------------------------VAEDLYQAGFISYPRTETDCFSQRTDLHV-----------------------GLWRNPSGGGHDDKAHPPIHPTK
                                 VAE+LYQAGFISYPRTETD FS RTDL                         GLWRNP+ GGHDDKAHPPIHPTK
Subjt:  -------------------------VAEDLYQAGFISYPRTETDCFSQRTDLHV-----------------------GLWRNPSGGGHDDKAHPPIHPTK

Query:  FSAGERGWSQDHHRLYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGVTRPPPLL
        FS+GE  WS+DH  +YELVVRH+LACVSQPAV A TTVEIDIAGE FS SGR ILA+NYL+VYRFESWGGS IP Y  GQQF+PTTLTLD+ VTRPPPLL
Subjt:  FSAGERGWSQDHHRLYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGVTRPPPLL

Query:  SEADLLSCMDK
         EADLLSCMDK
Subjt:  SEADLLSCMDK

Arabidopsis top hits

e value

%identity

Alignment

AT2G32000.1 DNA topoisomerase, type IA, core

6.3e-80

36.76

Show/hide

Query:  ITVLNVAEKPSVAKSVATILSRNQGLRVREGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELDFEERYRKWHSCDPVQLFHAPIRKFVPEDKMDIKRT
        + VL VAEKPS+A S+A++LS  Q +  R G +   ++ EF+   RG   +  VTSV GH+  +DF E+Y+ W + DP  LF API K     K  I R 
Subjt:  ITVLNVAEKPSVAKSVATILSRNQGLRVREGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELDFEERYRKWHSCDPVQLFHAPIRKFVPEDKMDIKRT

Query:  LEQEARRCQWLVLWLDCDREGENIAFEVVEVC--TTANHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLLKDAF
        L  EAR C ++VLWLDCDREGENI FEV+E       +    + RA FS++ E+DI +A+ NLV+PN+  A AVDARQEIDL++G +F+RFQT   +  +
Subjt:  LEQEARRCQWLVLWLDCDREGENIAFEVVEVC--TTANHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLLKDAF

Query:  -NIDSVADDKNIVLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMCIQESTATV--------------
         N+D        V+SYGPCQ PTLGF V+RY  I + +PE+FW +      D       W R  LFD   A VF ++ ++  TA V              
Subjt:  -NIDSVADDKNIVLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMCIQESTATV--------------

Query:  -------------------------AEDLYQAGFISYPRTETDCFSQR---TDLHVGLWRNPSGGGH----------------DDKAHPPIHPTKFSAGE
                                 AE LY  GFISYPRTE+  +      TD       NP  GG+                D   HPPI P + +A E
Subjt:  -------------------------AEDLYQAGFISYPRTETDCFSQR---TDLHVGLWRNPSGGGH----------------DDKAHPPIHPTKFSAGE

Query:  RGWSQDHHRLYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGVTRPPPLLSEADL
             D  RLY+ V +HFL  VS       T VE+ I GE F  +G+ +  + +  +  + +     +P+++ G++     + L  G T PP  L+E++L
Subjt:  RGWSQDHHRLYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGVTRPPPLLSEADL

Query:  LSCMDK
        +S M+K
Subjt:  LSCMDK

AT2G32000.2 DNA topoisomerase, type IA, core

4.2e-68

36.1

Show/hide

Query:  LMELDFEERYRKWHSCDPVQLFHAPIRKFVPEDKMDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVC--TTANHHLNIKRAHFSALIERDIHEAV
        +M  DF E+Y+ W + DP  LF API K     K  I R L  EAR C ++VLWLDCDREGENI FEV+E       +    + RA FS++ E+DI +A+
Subjt:  LMELDFEERYRKWHSCDPVQLFHAPIRKFVPEDKMDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVC--TTANHHLNIKRAHFSALIERDIHEAV

Query:  QNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLLKDAF-NIDSVADDKNIVLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFSW
         NLV+PN+  A AVDARQEIDL++G +F+RFQT   +  + N+D        V+SYGPCQ PTLGF V+RY  I + +PE+FW +      D       W
Subjt:  QNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLLKDAF-NIDSVADDKNIVLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFSW

Query:  TRGNLFDYTCAVVFYEMCIQESTATV---------------------------------------AEDLYQAGFISYPRTETDCFSQR---TDLHVGLWR
         R  LFD   A VF ++ ++  TA V                                       AE LY  GFISYPRTE+  +      TD       
Subjt:  TRGNLFDYTCAVVFYEMCIQESTATV---------------------------------------AEDLYQAGFISYPRTETDCFSQR---TDLHVGLWR

Query:  NPSGGGH----------------DDKAHPPIHPTKFSAGERGWSQDHHRLYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILARNYLDVYRF
        NP  GG+                D   HPPI P + +A E     D  RLY+ V +HFL  VS       T VE+ I GE F  +G+ +  + +  +  +
Subjt:  NPSGGGH----------------DDKAHPPIHPTKFSAGERGWSQDHHRLYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILARNYLDVYRF

Query:  ESWGGSTIPTYVSGQQFVPTTLTLDSGVTRPPPLLSEADLLSCMDK
         +     +P+++ G++     + L  G T PP  L+E++L+S M+K
Subjt:  ESWGGSTIPTYVSGQQFVPTTLTLDSGVTRPPPLLSEADLLSCMDK

AT5G63920.1 topoisomerase 3alpha

4.1e-204

67.71

Show/hide

Query:  GRPITVLNVAEKPSVAKSVATILSRNQGLRVREGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELDFEERYRKWHSCDPVQLFHAPIRKFVPEDKMDI
        G P+TVLNVAEKPSVAKSVA ILSR    R REGRSRYNKIFEF+YAI GQ C ML+TSV GHLMEL+F +RYRKWHSCDP  L+ AP+ K VPEDK DI
Subjt:  GRPITVLNVAEKPSVAKSVATILSRNQGLRVREGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELDFEERYRKWHSCDPVQLFHAPIRKFVPEDKMDI

Query:  KRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTTANHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLLKDA
        K+TLE+EAR+  WLVLWLDCDREGENIAFEVV+VC    H+L I+RAHFSALI+RDIHEAVQNL  PN+ FA+AVDARQEIDLRIGASFTRFQTMLL+D 
Subjt:  KRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTTANHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLLKDA

Query:  FNIDSVADDKNIVLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMCIQESTAT---------------
        F IDS  ++++ V+SYGPCQFPTLGF+VERYWEIQ+HEPEEFWTINCSH S++G++TF+W RG+LFDY  AV+ YEMC++E TAT               
Subjt:  FNIDSVADDKNIVLSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMCIQESTAT---------------

Query:  -------------------------VAEDLYQAGFISYPRTETDCFSQRTDLHV-----------------------GLWRNPSGGGHDDKAHPPIHPTK
                                 VAE+LYQAGFISYPRTETD FS RTDL                         GLWRNP+ GGHDDKAHPPIHPTK
Subjt:  -------------------------VAEDLYQAGFISYPRTETDCFSQRTDLHV-----------------------GLWRNPSGGGHDDKAHPPIHPTK

Query:  FSAGERGWSQDHHRLYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGVTRPPPLL
        FS+GE  WS+DH  +YELVVRH+LACVSQPAV A TTVEIDIAGE FS SGR ILA+NYL+VYRFESWGGS IP Y  GQQF+PTTLTLD+ VTRPPPLL
Subjt:  FSAGERGWSQDHHRLYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGVTRPPPLL

Query:  SEADLLSCMDK
         EADLLSCMDK
Subjt:  SEADLLSCMDK

Sequences

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CDS sequence

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ATGTCCAGCGGCCGTCCGATTACCGTCCTCAATGTGGCAGAGAAGCCATCGGTGGCGAAATCCGTGGCCACCATACTCTCCAGGAACCAGGGTCTTCGAGTTCGCGAAGG
TCGCTCTCGTTACAACAAGATTTTCGAGTTCAACTACGCCATTCGAGGCCAGTCTTGCAATATGCTCGTCACCTCCGTCACTGGCCACCTCATGGAGCTCGATTTTGAAG
AACGGTACCGGAAATGGCACTCCTGCGATCCAGTTCAGCTCTTCCACGCTCCCATCCGCAAATTTGTCCCCGAGGACAAGATGGATATAAAGAGGACTTTGGAACAAGAA
GCTAGAAGGTGCCAATGGCTCGTCCTTTGGCTTGATTGTGATAGAGAAGGAGAGAATATTGCATTTGAAGTGGTGGAAGTTTGCACAACAGCGAATCACCATCTTAACAT
TAAGAGAGCTCACTTCTCTGCTTTGATCGAAAGGGATATTCACGAAGCTGTGCAAAATCTTGTCCAACCGAATAAATGGTTTGCTGATGCAGTTGATGCTAGACAAGAAA
TCGATCTAAGAATTGGAGCTTCTTTCACTAGGTTCCAAACTATGCTGTTGAAAGATGCATTTAATATTGATTCTGTCGCAGATGACAAAAATATTGTGTTGAGTTATGGG
CCATGTCAGTTTCCTACTCTTGGCTTTGTTGTTGAGCGGTACTGGGAGATTCAATCCCATGAGCCAGAAGAATTTTGGACGATCAACTGTTCACACAATTCTGATGATGG
GATTTCTACATTTAGTTGGACAAGAGGGAATCTATTTGATTATACTTGTGCTGTTGTATTCTATGAAATGTGCATACAAGAATCCACTGCTACGGTGGCCGAAGATCTAT
ACCAAGCAGGTTTCATTAGTTATCCTCGTACAGAGACTGATTGCTTTTCTCAAAGGACCGATCTTCATGTAGGGCTGTGGAGGAATCCTAGTGGTGGTGGGCATGATGAC
AAAGCCCATCCACCTATTCACCCAACAAAGTTCTCAGCTGGGGAACGCGGATGGAGCCAAGATCACCATAGATTATATGAGCTAGTCGTTCGCCATTTCCTTGCATGTGT
GTCACAGCCAGCTGTAGGTGCTGTGACTACTGTTGAAATTGATATTGCTGGTGAATTGTTTTCTACATCTGGGAGAATGATACTAGCAAGAAATTACCTGGATGTTTACC
GCTTTGAATCATGGGGAGGTTCAACTATTCCAACATACGTTTCCGGGCAACAGTTTGTTCCAACAACATTAACTCTTGATTCGGGAGTCACGAGACCACCTCCCCTTCTG
AGTGAAGCTGATTTGCTTTCTTGTATGGATAAGGTAAGTGAGATGTGTTTGCCAACTGAGCTTATCAAATTCTGGGGTTTGAACCTTTATGTTGGACTAGAATTTATATT
GCAATCGAGTGGGGAAGCCTTTATCTTTGATTAA

mRNA sequence

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GCCTTCCAAAATCTCAGTGCTGTTGCTCGGACACGGGCGGTGCAGTAGCCATGTCCAGCGGCCGTCCGATTACCGTCCTCAATGTGGCAGAGAAGCCATCGGTGGCGAAA
TCCGTGGCCACCATACTCTCCAGGAACCAGGGTCTTCGAGTTCGCGAAGGTCGCTCTCGTTACAACAAGATTTTCGAGTTCAACTACGCCATTCGAGGCCAGTCTTGCAA
TATGCTCGTCACCTCCGTCACTGGCCACCTCATGGAGCTCGATTTTGAAGAACGGTACCGGAAATGGCACTCCTGCGATCCAGTTCAGCTCTTCCACGCTCCCATCCGCA
AATTTGTCCCCGAGGACAAGATGGATATAAAGAGGACTTTGGAACAAGAAGCTAGAAGGTGCCAATGGCTCGTCCTTTGGCTTGATTGTGATAGAGAAGGAGAGAATATT
GCATTTGAAGTGGTGGAAGTTTGCACAACAGCGAATCACCATCTTAACATTAAGAGAGCTCACTTCTCTGCTTTGATCGAAAGGGATATTCACGAAGCTGTGCAAAATCT
TGTCCAACCGAATAAATGGTTTGCTGATGCAGTTGATGCTAGACAAGAAATCGATCTAAGAATTGGAGCTTCTTTCACTAGGTTCCAAACTATGCTGTTGAAAGATGCAT
TTAATATTGATTCTGTCGCAGATGACAAAAATATTGTGTTGAGTTATGGGCCATGTCAGTTTCCTACTCTTGGCTTTGTTGTTGAGCGGTACTGGGAGATTCAATCCCAT
GAGCCAGAAGAATTTTGGACGATCAACTGTTCACACAATTCTGATGATGGGATTTCTACATTTAGTTGGACAAGAGGGAATCTATTTGATTATACTTGTGCTGTTGTATT
CTATGAAATGTGCATACAAGAATCCACTGCTACGGTGGCCGAAGATCTATACCAAGCAGGTTTCATTAGTTATCCTCGTACAGAGACTGATTGCTTTTCTCAAAGGACCG
ATCTTCATGTAGGGCTGTGGAGGAATCCTAGTGGTGGTGGGCATGATGACAAAGCCCATCCACCTATTCACCCAACAAAGTTCTCAGCTGGGGAACGCGGATGGAGCCAA
GATCACCATAGATTATATGAGCTAGTCGTTCGCCATTTCCTTGCATGTGTGTCACAGCCAGCTGTAGGTGCTGTGACTACTGTTGAAATTGATATTGCTGGTGAATTGTT
TTCTACATCTGGGAGAATGATACTAGCAAGAAATTACCTGGATGTTTACCGCTTTGAATCATGGGGAGGTTCAACTATTCCAACATACGTTTCCGGGCAACAGTTTGTTC
CAACAACATTAACTCTTGATTCGGGAGTCACGAGACCACCTCCCCTTCTGAGTGAAGCTGATTTGCTTTCTTGTATGGATAAGGTAAGTGAGATGTGTTTGCCAACTGAG
CTTATCAAATTCTGGGGTTTGAACCTTTATGTTGGACTAGAATTTATATTGCAATCGAGTGGGGAAGCCTTTATCTTTGATTAA

Protein sequence

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MSSGRPITVLNVAEKPSVAKSVATILSRNQGLRVREGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELDFEERYRKWHSCDPVQLFHAPIRKFVPEDKMDIKRTLEQE
ARRCQWLVLWLDCDREGENIAFEVVEVCTTANHHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLLKDAFNIDSVADDKNIVLSYG
PCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFSWTRGNLFDYTCAVVFYEMCIQESTATVAEDLYQAGFISYPRTETDCFSQRTDLHVGLWRNPSGGGHDD
KAHPPIHPTKFSAGERGWSQDHHRLYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILARNYLDVYRFESWGGSTIPTYVSGQQFVPTTLTLDSGVTRPPPLL
SEADLLSCMDKVSEMCLPTELIKFWGLNLYVGLEFILQSSGEAFIFD

Lsi03G016850 (gene) of Bottle gourd (USVL1VR-Ls) v1 genome