CuGenDBv2

Gene ID	MC10g0080
Organism	Momordica charantia cv. Dali-11 (Bitter gourd (Dali-11) v1)
Description	dihydrofolate synthetase isoform X1
Genome location	MC10:514301..519828
RNA-Seq Expression	MC10g0080
Synteny	MC10g0080
Gene Ontology terms	GO:0006761 - dihydrofolate biosynthetic process (biological process) GO:0009793 - embryo development ending in seed dormancy (biological process) GO:0046901 - tetrahydrofolylpolyglutamate biosynthetic process (biological process) GO:0005759 - mitochondrial matrix (cellular component) GO:0005829 - cytosol (cellular component) GO:0004326 - tetrahydrofolylpolyglutamate synthase activity (molecular function) GO:0005524 - ATP binding (molecular function) GO:0008841 - dihydrofolate synthase activity (molecular function) GO:0046872 - metal ion binding (molecular function)
InterPro domains	IPR001645 - Folylpolyglutamate synthetase IPR013221 - Mur ligase, central IPR018109 - Folylpolyglutamate synthetase, conserved site IPR036565 - Mur-like, catalytic domain superfamily IPR036615 - Mur ligase, C-terminal domain superfamily

Homology

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GenBank top hits

e value

%identity

Alignment

KAG6576673.1 Dihydrofolate synthetase, partial [Cucurbita argyrosperma subsp. sororia]

0.0

85.87

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Query:  MNVFKYHRRYRPQILGGLLLNFLVGEGPSISCRIGSKQCFATHSEDLELTEFMEYLDSLKNYEKLGVPRGAGTDSDDGFDLGRMRRLMERLGNPQSKFKA
        MN+FKYH  +RPQI G LLLN+ VGEGPSIS RIGSKQCF  HSED ++TEFMEYLDSLKNYEKLGVP GAGT+S+DGFDLGRM+RLMERLGNPQSKFKA
Subjt:  MNVFKYHRRYRPQILGGLLLNFLVGEGPSISCRIGSKQCFATHSEDLELTEFMEYLDSLKNYEKLGVPRGAGTDSDDGFDLGRMRRLMERLGNPQSKFKA

Query:  IHIAGTKGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISLGRSGEMVSGKALNSLFKRNKEFLDQSVEFENGRISHFEVLTAMAFSLFAQENVDVA
        IHIAGTKGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISLGRSGEMVSGKALN LFKRNKE LDQSV+ ENGRISHFEVLTAMAFSLFAQENVDVA
Subjt:  IHIAGTKGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISLGRSGEMVSGKALNSLFKRNKEFLDQSVEFENGRISHFEVLTAMAFSLFAQENVDVA

Query:  VIEAGLGGARDATNIICSSRLAAAVITSIGEEHMAALGGSLESIAMAKAGIIKHGCPTILGGPFLPSIECILHDKALSMSSYVISASYPGHRSTIKGVSL
        VIEAGLGGARDATNIICSSRLAAAVITSIGEEHMAALGGSLESIAMAKAGIIKHGCPTILGGPF+P+IECIL DKALSMSS V+SAS PG+RSTIKGVSL
Subjt:  VIEAGLGGARDATNIICSSRLAAAVITSIGEEHMAALGGSLESIAMAKAGIIKHGCPTILGGPFLPSIECILHDKALSMSSYVISASYPGHRSTIKGVSL

Query:  LDGRLCQCCDIVIQIDNEFIELLDVNLRMLGRHQLQNAATATCAILTLRNLGWRISDSSIKTGLEQTFLVGRSHFLSAKEAGVLGLPGATILLDGGAFIF
        L+GRLCQCCD++IQ DNEFIEL DVNLRMLGRHQLQNAATATC ILTLRNLGWRIS++SI++GLE+TFLVGRSHFLSAKEAG+LGLPG  ILLDG     
Subjt:  LDGRLCQCCDIVIQIDNEFIELLDVNLRMLGRHQLQNAATATCAILTLRNLGWRISDSSIKTGLEQTFLVGRSHFLSAKEAGVLGLPGATILLDGGAFIF

Query:  LFITVKFGLLGDEAHTKDSAKALVDTIQMTFPEARLALVVAMASDKDHVGFAREFLQGGKLESIILTEANIGGGKSRTTSAAILRDCWIQAANELGIPIS
                     AHTKDSAKALVDTIQM+FP+A+LALVVAMASDKDH GFA EFLQGGKLESI+L+EANIGGGKSRTTSAA+LRDCWIQA+NE+GIPIS
Subjt:  LFITVKFGLLGDEAHTKDSAKALVDTIQMTFPEARLALVVAMASDKDHVGFAREFLQGGKLESIILTEANIGGGKSRTTSAAILRDCWIQAANELGIPIS

Query:  LETKDALVSSTSKLESRPILTTETSLLHAMKIAAEILKQRTEGRAGLTVVTGSLHAVSMVLSSLHS
        LETKDA VSSTSKLE+RP+LTTETSLL A+KIAAEILKQR +GR GL VVTGSLHAVSMVLSSLHS
Subjt:  LETKDALVSSTSKLESRPILTTETSLLHAMKIAAEILKQRTEGRAGLTVVTGSLHAVSMVLSSLHS

XP_022141068.1 dihydrofolate synthetase isoform X1 [Momordica charantia]

0.0

96.82

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Query:  MNVFKYHRRYRPQILGGLLLNFLVGEGPSISCRIGSKQCFATHSEDLELTEFMEYLDSLKNYEKLGVPRGAGTDSDDGFDLGRMRRLMERLGNPQSKFKA
        MNVFKYHRRYRPQILGGLLLNFLVGEGPSISCRIGSKQCFATHSEDLELTEFMEYLDSLKNYEKLGVPRGAGTDSDDGFDLGRMRRLMERLGNPQSKFKA
Subjt:  MNVFKYHRRYRPQILGGLLLNFLVGEGPSISCRIGSKQCFATHSEDLELTEFMEYLDSLKNYEKLGVPRGAGTDSDDGFDLGRMRRLMERLGNPQSKFKA

Query:  IHIAGTKGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISLGRSGEMVSGKALNSLFKRNKEFLDQSVEFENGRISHFEVLTAMAFSLFAQENVDVA
        IHIAGTKGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISLGRSGEMVSGKALNSLFKRNKEFLDQSVEFENGRISHFEVLTAMAFSLFAQENVDVA
Subjt:  IHIAGTKGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISLGRSGEMVSGKALNSLFKRNKEFLDQSVEFENGRISHFEVLTAMAFSLFAQENVDVA

Query:  VIEAGLGGARDATNIICSSRLAAAVITSIGEEHMAALGGSLESIAMAKAGIIKHGCPTILGGPFLPSIECILHDKALSMSSYVISASYPGHRSTIKGVSL
        VIEAGLGGARDATNIICSSRLAAAVITSIGEEHMAALGGSLESIAMAKAGIIKHGCPTILGGPFLPSIECILHDKALSMSSYVISASYPGHRSTIKGVSL
Subjt:  VIEAGLGGARDATNIICSSRLAAAVITSIGEEHMAALGGSLESIAMAKAGIIKHGCPTILGGPFLPSIECILHDKALSMSSYVISASYPGHRSTIKGVSL

Query:  LDGRLCQCCDIVIQIDNEFIELLDVNLRMLGRHQLQNAATATCAILTLRNLGWRISDSSIKTGLEQTFLVGRSHFLSAKEAGVLGLPGATILLDGGAFIF
        LDGRLCQCCDIVIQIDNEFIELLDVNLRMLGRHQLQNAATATCAILTLRNLGWRISDSSIKTGLEQTFLVGRSHFLSAKEAGVLGLPGATILLDG     
Subjt:  LDGRLCQCCDIVIQIDNEFIELLDVNLRMLGRHQLQNAATATCAILTLRNLGWRISDSSIKTGLEQTFLVGRSHFLSAKEAGVLGLPGATILLDGGAFIF

Query:  LFITVKFGLLGDEAHTKDSAKALVDTIQMTFPEARLALVVAMASDKDHVGFAREFLQGGKLESIILTEANIGGGKSRTTSAAILRDCWIQAANELGIPIS
                     AHTKDSAKALVDTIQMTFPEARLALVVAMASDKDHVGFAREFLQGGKLESIILTEANIGGGKSRTTSAAILRDCWIQAANELGIPIS
Subjt:  LFITVKFGLLGDEAHTKDSAKALVDTIQMTFPEARLALVVAMASDKDHVGFAREFLQGGKLESIILTEANIGGGKSRTTSAAILRDCWIQAANELGIPIS

Query:  LETKDALVSSTSKLESRPILTTETSLLHAMKIAAEILKQRTEGRAGLTVVTGSLHAVSMVLSSLHS
        LETKDALVSSTSKLESRPILTTETSLLHAMKIAAEILKQRTEGRAGLTVVTGSLHAVSMVLSSLHS
Subjt:  LETKDALVSSTSKLESRPILTTETSLLHAMKIAAEILKQRTEGRAGLTVVTGSLHAVSMVLSSLHS

XP_022922898.1 dihydrofolate synthetase isoform X1 [Cucurbita moschata]

0.0

85.69

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Query:  MNVFKYHRRYRPQILGGLLLNFLVGEGPSISCRIGSKQCFATHSEDLELTEFMEYLDSLKNYEKLGVPRGAGTDSDDGFDLGRMRRLMERLGNPQSKFKA
        MN+FKYH  +RPQI G LLLN+ VGEGPSIS RIGSKQCF  HSED ++TEFMEYLDSLKNYEKLGVP GAGTDS+DGFDLGRM+RLMERLGNPQSKFKA
Subjt:  MNVFKYHRRYRPQILGGLLLNFLVGEGPSISCRIGSKQCFATHSEDLELTEFMEYLDSLKNYEKLGVPRGAGTDSDDGFDLGRMRRLMERLGNPQSKFKA

Query:  IHIAGTKGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISLGRSGEMVSGKALNSLFKRNKEFLDQSVEFENGRISHFEVLTAMAFSLFAQENVDVA
        IHIAGTKGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISLGRSGEMVSGKALN LFKRNKE LDQSV+ ENGRISHFEVLTAMAFSLFAQENVDVA
Subjt:  IHIAGTKGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISLGRSGEMVSGKALNSLFKRNKEFLDQSVEFENGRISHFEVLTAMAFSLFAQENVDVA

Query:  VIEAGLGGARDATNIICSSRLAAAVITSIGEEHMAALGGSLESIAMAKAGIIKHGCPTILGGPFLPSIECILHDKALSMSSYVISASYPGHRSTIKGVSL
        VIEAGLGGARDATNIICSSRLAAAVITSIGEEHMAALGGSLESIAMAKAGIIKHGCPTILGGPF+P+IECIL DKALSMSS V+SAS PG+RS+IKGVSL
Subjt:  VIEAGLGGARDATNIICSSRLAAAVITSIGEEHMAALGGSLESIAMAKAGIIKHGCPTILGGPFLPSIECILHDKALSMSSYVISASYPGHRSTIKGVSL

Query:  LDGRLCQCCDIVIQIDNEFIELLDVNLRMLGRHQLQNAATATCAILTLRNLGWRISDSSIKTGLEQTFLVGRSHFLSAKEAGVLGLPGATILLDGGAFIF
        L+GRLCQCCD++IQ DNEFIEL DVNLRMLGRHQLQNAATATC ILTLRNLGWRIS++SI++GLE+TFLVGRSHFLSAKEAG+LGLPG  ILLDG     
Subjt:  LDGRLCQCCDIVIQIDNEFIELLDVNLRMLGRHQLQNAATATCAILTLRNLGWRISDSSIKTGLEQTFLVGRSHFLSAKEAGVLGLPGATILLDGGAFIF

Query:  LFITVKFGLLGDEAHTKDSAKALVDTIQMTFPEARLALVVAMASDKDHVGFAREFLQGGKLESIILTEANIGGGKSRTTSAAILRDCWIQAANELGIPIS
                     AHTKDSAKALVDTIQM+FP+A+LALVVAMASDKDH GFA EFLQGGKLESI+L+EANIGG KSRTTSAA+LRDCWIQA+NE+GIPIS
Subjt:  LFITVKFGLLGDEAHTKDSAKALVDTIQMTFPEARLALVVAMASDKDHVGFAREFLQGGKLESIILTEANIGGGKSRTTSAAILRDCWIQAANELGIPIS

Query:  LETKDALVSSTSKLESRPILTTETSLLHAMKIAAEILKQRTEGRAGLTVVTGSLHAVSMVLSSLHS
        LETKDA VSSTSKLE+RP+LTTETSLL A+KIAAEILKQR +GR GL VVTGSLHAVSMVLSSLHS
Subjt:  LETKDALVSSTSKLESRPILTTETSLLHAMKIAAEILKQRTEGRAGLTVVTGSLHAVSMVLSSLHS

XP_023553540.1 dihydrofolate synthetase [Cucurbita pepo subsp. pepo]

0.0

86.4

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Query:  MNVFKYHRRYRPQILGGLLLNFLVGEGPSISCRIGSKQCFATHSEDLELTEFMEYLDSLKNYEKLGVPRGAGTDSDDGFDLGRMRRLMERLGNPQSKFKA
        MN+FKYH  +RPQI G LLLN+ VGEGPSIS RIGSKQCF  HSED ++TEFMEYLDSLKNYEKLGVP GAGTDS+DGFDLGRM+RLMERLGNPQSKFKA
Subjt:  MNVFKYHRRYRPQILGGLLLNFLVGEGPSISCRIGSKQCFATHSEDLELTEFMEYLDSLKNYEKLGVPRGAGTDSDDGFDLGRMRRLMERLGNPQSKFKA

Query:  IHIAGTKGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISLGRSGEMVSGKALNSLFKRNKEFLDQSVEFENGRISHFEVLTAMAFSLFAQENVDVA
        IHIAGTKGKGSTAAFLS+ILRAEGYSVGCYTSPHIETIRERISLGRSGEMVSGKALN LFKRNKE LDQSV+ ENGRISHFEVLTAMAFSLFAQENVDVA
Subjt:  IHIAGTKGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISLGRSGEMVSGKALNSLFKRNKEFLDQSVEFENGRISHFEVLTAMAFSLFAQENVDVA

Query:  VIEAGLGGARDATNIICSSRLAAAVITSIGEEHMAALGGSLESIAMAKAGIIKHGCPTILGGPFLPSIECILHDKALSMSSYVISASYPGHRSTIKGVSL
        VIEAGLGGARDATNIICSSRLAAAVITSIGEEHMAALGGSLESIAMAKAGIIKHGCPTILGGPF+P+IECIL DKALSMSS V+SAS PG+RSTIKGVSL
Subjt:  VIEAGLGGARDATNIICSSRLAAAVITSIGEEHMAALGGSLESIAMAKAGIIKHGCPTILGGPFLPSIECILHDKALSMSSYVISASYPGHRSTIKGVSL

Query:  LDGRLCQCCDIVIQIDNEFIELLDVNLRMLGRHQLQNAATATCAILTLRNLGWRISDSSIKTGLEQTFLVGRSHFLSAKEAGVLGLPGATILLDGGAFIF
        L+GRLCQCCD++IQ DNEFIEL DVNLRMLGRHQLQNAATATC ILTLRNLGWRISD+SI++GLE+TFLVGRSHFLSAKEAG+LGLPG TILLDG     
Subjt:  LDGRLCQCCDIVIQIDNEFIELLDVNLRMLGRHQLQNAATATCAILTLRNLGWRISDSSIKTGLEQTFLVGRSHFLSAKEAGVLGLPGATILLDGGAFIF

Query:  LFITVKFGLLGDEAHTKDSAKALVDTIQMTFPEARLALVVAMASDKDHVGFAREFLQGGKLESIILTEANIGGGKSRTTSAAILRDCWIQAANELGIPIS
                     AHTKDSAKALVDTIQM+FP+A+LALVVAMASDKDH GFA EFLQGGKLESI+L+EANIGGGKSRTTSAA+LRDCWIQA+NE+GIPIS
Subjt:  LFITVKFGLLGDEAHTKDSAKALVDTIQMTFPEARLALVVAMASDKDHVGFAREFLQGGKLESIILTEANIGGGKSRTTSAAILRDCWIQAANELGIPIS

Query:  LETKDALVSSTSKLESRPILTTETSLLHAMKIAAEILKQRTEGRAGLTVVTGSLHAVSMVLSSLHS
        LETKDA VSSTSKLE+RP+LTTETSLL A+KIAAEILKQR EGR GL VVTGSLHAVSMVLSSLHS
Subjt:  LETKDALVSSTSKLESRPILTTETSLLHAMKIAAEILKQRTEGRAGLTVVTGSLHAVSMVLSSLHS

XP_038905573.1 dihydrofolate synthetase [Benincasa hispida]

0.0

86.22

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Query:  MNVFKYHRRYRPQILGGLLLNFLVGEGPSISCRIGSKQCFATHSEDLELTEFMEYLDSLKNYEKLGVPRGAGTDSDDGFDLGRMRRLMERLGNPQSKFKA
        M +FKYH   RPQILG LLLN   GE PSIS RIGSKQCF+TH ED  +TEFMEYLDSLKNYEKLGVP+GAGTDSDDGFDLGRMRRLMERLGNPQSKFKA
Subjt:  MNVFKYHRRYRPQILGGLLLNFLVGEGPSISCRIGSKQCFATHSEDLELTEFMEYLDSLKNYEKLGVPRGAGTDSDDGFDLGRMRRLMERLGNPQSKFKA

Query:  IHIAGTKGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISLGRSGEMVSGKALNSLFKRNKEFLDQSVEFENGRISHFEVLTAMAFSLFAQENVDVA
        IHIAGTKGKGSTAAFLSNILRAEGYS GCYTSPHIETIRERISLGRSGEMVSGKALNSLFKRNKEF DQSVE ENGRISHFEVLTAMAF LFAQENVD+A
Subjt:  IHIAGTKGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISLGRSGEMVSGKALNSLFKRNKEFLDQSVEFENGRISHFEVLTAMAFSLFAQENVDVA

Query:  VIEAGLGGARDATNIICSSRLAAAVITSIGEEHMAALGGSLESIAMAKAGIIKHGCPTILGGPFLPSIECILHDKALSMSSYVISASYPGHRSTIKGVSL
        VIEAGLGGARDATNIICSS LAAAVITSIGEEHMAALGGSLESIA AKAGIIK GCP ILGGPFLPSIE IL DKALSMSS VISAS PG+RSTIKGVSL
Subjt:  VIEAGLGGARDATNIICSSRLAAAVITSIGEEHMAALGGSLESIAMAKAGIIKHGCPTILGGPFLPSIECILHDKALSMSSYVISASYPGHRSTIKGVSL

Query:  LDGRLCQCCDIVIQIDNEFIELLDVNLRMLGRHQLQNAATATCAILTLRNLGWRISDSSIKTGLEQTFLVGRSHFLSAKEAGVLGLPGATILLDGGAFIF
        L+G +CQCCD+VIQID+EFIELLDVNLRMLG HQLQNAATATC IL LRNLGWRISD+S+++GLEQTFLVGRSHFL AKEAGVLGLPGATILLDG     
Subjt:  LDGRLCQCCDIVIQIDNEFIELLDVNLRMLGRHQLQNAATATCAILTLRNLGWRISDSSIKTGLEQTFLVGRSHFLSAKEAGVLGLPGATILLDGGAFIF

Query:  LFITVKFGLLGDEAHTKDSAKALVDTIQMTFPEARLALVVAMASDKDHVGFAREFLQGGKLESIILTEANIGGGKSRTTSAAILRDCWIQAANELGIPIS
                     AHTKDSAKALVDTIQM FPEARLALVVAMASDKDH+GFAREFLQGGKLESI+LTEA+IGGGKSRTTSA  LRDCWIQA+NELGIPIS
Subjt:  LFITVKFGLLGDEAHTKDSAKALVDTIQMTFPEARLALVVAMASDKDHVGFAREFLQGGKLESIILTEANIGGGKSRTTSAAILRDCWIQAANELGIPIS

Query:  LETKDALVSSTSKLESRPILTTETSLLHAMKIAAEILKQRTEGRAGLTVVTGSLHAVSMVLSSLHS
        LETKDA VS TSKLE+RP+LTTETSLLHA+K+AAEILKQRTEGR GL VVTGSLHAVSMVLS LHS
Subjt:  LETKDALVSSTSKLESRPILTTETSLLHAMKIAAEILKQRTEGRAGLTVVTGSLHAVSMVLSSLHS

TrEMBL top hits

e value

%identity

Alignment

A0A0A0L7A4 Mur_ligase_M domain-containing protein

0.0

84.81

Show/hide

Query:  MNVFKYHRRYRPQILGGLLLNFLVGEGPSISCRIGSKQCFATHSEDLELTEFMEYLDSLKNYEKLGVPRGAGTDSDDGFDLGRMRRLMERLGNPQSKFKA
        MNVFKYH   RPQILG LLLN  +GE PSIS R GSKQCFATHSED  +T+FMEYLDSLKNYEKLGVPRG+GTDSDDGFDLGRMRRLMERLGNPQS+FKA
Subjt:  MNVFKYHRRYRPQILGGLLLNFLVGEGPSISCRIGSKQCFATHSEDLELTEFMEYLDSLKNYEKLGVPRGAGTDSDDGFDLGRMRRLMERLGNPQSKFKA

Query:  IHIAGTKGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISLGRSGEMVSGKALNSLFKRNKEFLDQSVEFENGRISHFEVLTAMAFSLFAQENVDVA
        IHIAGTKGKGSTAAFLSNILR EGYSVGCYTSPHIETIRERISLGRSG+MVSGKALNSLFKRNKE  DQSVE ENG +SHFEVLTAMAFSLFAQE+VDVA
Subjt:  IHIAGTKGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISLGRSGEMVSGKALNSLFKRNKEFLDQSVEFENGRISHFEVLTAMAFSLFAQENVDVA

Query:  VIEAGLGGARDATNIICSSRLAAAVITSIGEEHMAALGGSLESIAMAKAGIIKHGCPTILGGPFLPSIECILHDKALSMSSYVISASYPGHRSTIKGVSL
        VIEAGLGGARDATNIICSS LAAAVITSIGEEH+AALGGSLESIA AKAGIIK GCPTILGGPFLP IE IL DKALSMSS VISAS PG+RSTIKGV+L
Subjt:  VIEAGLGGARDATNIICSSRLAAAVITSIGEEHMAALGGSLESIAMAKAGIIKHGCPTILGGPFLPSIECILHDKALSMSSYVISASYPGHRSTIKGVSL

Query:  LDGRLCQCCDIVIQIDNEFIELLDVNLRMLGRHQLQNAATATCAILTLRNLGWRISDSSIKTGLEQTFLVGRSHFLSAKEAGVLGLPGATILLDGGAFIF
        L+G L QCCDIVIQIDNEFIELLDVNLRMLG HQLQNAATATC ILTLRNLGWRISD+SI++GLEQTFL+GRSHFL+A+EA VLGLPGATILLDG     
Subjt:  LDGRLCQCCDIVIQIDNEFIELLDVNLRMLGRHQLQNAATATCAILTLRNLGWRISDSSIKTGLEQTFLVGRSHFLSAKEAGVLGLPGATILLDGGAFIF

Query:  LFITVKFGLLGDEAHTKDSAKALVDTIQMTFPEARLALVVAMASDKDHVGFAREFLQGGKLESIILTEANIGGGKSRTTSAAILRDCWIQAANELGIPIS
                     AHTKDSAKAL+DTIQM FPEA+LALVVAMASDK+HVGFAREFLQGGKLES++LTEA IGGGKSRTTSAA LRDCWIQA+NELGIPIS
Subjt:  LFITVKFGLLGDEAHTKDSAKALVDTIQMTFPEARLALVVAMASDKDHVGFAREFLQGGKLESIILTEANIGGGKSRTTSAAILRDCWIQAANELGIPIS

Query:  LETKDALVSSTSKLESRPILTTETSLLHAMKIAAEILKQRTEGRAGLTVVTGSLHAVSMVLSSLHS
        LETKDA V  TSKL +RP+LTTETSLLHA+KIAAEILKQRT+GR GL VV+GSLHAVSMVL+SLHS
Subjt:  LETKDALVSSTSKLESRPILTTETSLLHAMKIAAEILKQRTEGRAGLTVVTGSLHAVSMVLSSLHS

A0A1S3CNR7 dihydrofolate synthetase isoform X1

0.0

85.51

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Query:  MNVFKYHRRYRPQILGGLLLNFLVGEGPSISCRIGSKQCFATHSEDLELTEFMEYLDSLKNYEKLGVPRGAGTDSDDGFDLGRMRRLMERLGNPQSKFKA
        MNVFKYH   RPQILG LLLN  +GE PSIS R GSKQCFATHSED  +TEFMEYLDSLKNYEKLGVPRGAGTDSDDGFDLGRMRRLMERLGNPQSKFKA
Subjt:  MNVFKYHRRYRPQILGGLLLNFLVGEGPSISCRIGSKQCFATHSEDLELTEFMEYLDSLKNYEKLGVPRGAGTDSDDGFDLGRMRRLMERLGNPQSKFKA

Query:  IHIAGTKGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISLGRSGEMVSGKALNSLFKRNKEFLDQSVEFENGRISHFEVLTAMAFSLFAQENVDVA
        IHIAGTKGKGS AAFLSNILRAEGYSVGCYTSPHIET+RERISLGRSGEMVSGKALNSLFKRNKE  DQSVE E+GRISHFEVLTAMAFSLFAQENVDVA
Subjt:  IHIAGTKGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISLGRSGEMVSGKALNSLFKRNKEFLDQSVEFENGRISHFEVLTAMAFSLFAQENVDVA

Query:  VIEAGLGGARDATNIICSSRLAAAVITSIGEEHMAALGGSLESIAMAKAGIIKHGCPTILGGPFLPSIECILHDKALSMSSYVISASYPGHRSTIKGVSL
        VIEAGLGGARDATNIICSS LAAAVITSIGEEHMAALGGSLESIAMAKAGIIK GCPTILGG FLP IE IL DKALSMSS VI+ S PG+RSTIKGV++
Subjt:  VIEAGLGGARDATNIICSSRLAAAVITSIGEEHMAALGGSLESIAMAKAGIIKHGCPTILGGPFLPSIECILHDKALSMSSYVISASYPGHRSTIKGVSL

Query:  LDGRLCQCCDIVIQIDNEFIELLDVNLRMLGRHQLQNAATATCAILTLRNLGWRISDSSIKTGLEQTFLVGRSHFLSAKEAGVLGLPGATILLDGGAFIF
        L+G LCQCCDIVIQIDNEF+ELLDVNLRMLGRHQLQNAATATC ILTLRNLGWRISD+SI++GLEQTFL+GRSHFL+AKEA VLGLPGATILLDG     
Subjt:  LDGRLCQCCDIVIQIDNEFIELLDVNLRMLGRHQLQNAATATCAILTLRNLGWRISDSSIKTGLEQTFLVGRSHFLSAKEAGVLGLPGATILLDGGAFIF

Query:  LFITVKFGLLGDEAHTKDSAKALVDTIQMTFPEARLALVVAMASDKDHVGFAREFLQGGKLESIILTEANIGGGKSRTTSAAILRDCWIQAANELGIPIS
                     AHTKDSAKALVDTIQM FPEARLALV+AMASDK+HV FAREFLQGGKLE ++LTEA+IGGGKSRTTSAA LRDCWIQA+ ELGIPIS
Subjt:  LFITVKFGLLGDEAHTKDSAKALVDTIQMTFPEARLALVVAMASDKDHVGFAREFLQGGKLESIILTEANIGGGKSRTTSAAILRDCWIQAANELGIPIS

Query:  LETKDALVSSTSKLESRPILTTETSLLHAMKIAAEILKQRTEGRAGLTVVTGSLHAVSMVLSSLHS
        LETKDA VS TSKLE+RP+LTTETSLLHA+KIAAEILKQRT+G+  L VV+GSLHAVSMVLSSLHS
Subjt:  LETKDALVSSTSKLESRPILTTETSLLHAMKIAAEILKQRTEGRAGLTVVTGSLHAVSMVLSSLHS

A0A6J1CJG1 dihydrofolate synthetase isoform X1

0.0

96.82

Show/hide

Query:  MNVFKYHRRYRPQILGGLLLNFLVGEGPSISCRIGSKQCFATHSEDLELTEFMEYLDSLKNYEKLGVPRGAGTDSDDGFDLGRMRRLMERLGNPQSKFKA
        MNVFKYHRRYRPQILGGLLLNFLVGEGPSISCRIGSKQCFATHSEDLELTEFMEYLDSLKNYEKLGVPRGAGTDSDDGFDLGRMRRLMERLGNPQSKFKA
Subjt:  MNVFKYHRRYRPQILGGLLLNFLVGEGPSISCRIGSKQCFATHSEDLELTEFMEYLDSLKNYEKLGVPRGAGTDSDDGFDLGRMRRLMERLGNPQSKFKA

Query:  IHIAGTKGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISLGRSGEMVSGKALNSLFKRNKEFLDQSVEFENGRISHFEVLTAMAFSLFAQENVDVA
        IHIAGTKGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISLGRSGEMVSGKALNSLFKRNKEFLDQSVEFENGRISHFEVLTAMAFSLFAQENVDVA
Subjt:  IHIAGTKGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISLGRSGEMVSGKALNSLFKRNKEFLDQSVEFENGRISHFEVLTAMAFSLFAQENVDVA

Query:  VIEAGLGGARDATNIICSSRLAAAVITSIGEEHMAALGGSLESIAMAKAGIIKHGCPTILGGPFLPSIECILHDKALSMSSYVISASYPGHRSTIKGVSL
        VIEAGLGGARDATNIICSSRLAAAVITSIGEEHMAALGGSLESIAMAKAGIIKHGCPTILGGPFLPSIECILHDKALSMSSYVISASYPGHRSTIKGVSL
Subjt:  VIEAGLGGARDATNIICSSRLAAAVITSIGEEHMAALGGSLESIAMAKAGIIKHGCPTILGGPFLPSIECILHDKALSMSSYVISASYPGHRSTIKGVSL

Query:  LDGRLCQCCDIVIQIDNEFIELLDVNLRMLGRHQLQNAATATCAILTLRNLGWRISDSSIKTGLEQTFLVGRSHFLSAKEAGVLGLPGATILLDGGAFIF
        LDGRLCQCCDIVIQIDNEFIELLDVNLRMLGRHQLQNAATATCAILTLRNLGWRISDSSIKTGLEQTFLVGRSHFLSAKEAGVLGLPGATILLDG     
Subjt:  LDGRLCQCCDIVIQIDNEFIELLDVNLRMLGRHQLQNAATATCAILTLRNLGWRISDSSIKTGLEQTFLVGRSHFLSAKEAGVLGLPGATILLDGGAFIF

Query:  LFITVKFGLLGDEAHTKDSAKALVDTIQMTFPEARLALVVAMASDKDHVGFAREFLQGGKLESIILTEANIGGGKSRTTSAAILRDCWIQAANELGIPIS
                     AHTKDSAKALVDTIQMTFPEARLALVVAMASDKDHVGFAREFLQGGKLESIILTEANIGGGKSRTTSAAILRDCWIQAANELGIPIS
Subjt:  LFITVKFGLLGDEAHTKDSAKALVDTIQMTFPEARLALVVAMASDKDHVGFAREFLQGGKLESIILTEANIGGGKSRTTSAAILRDCWIQAANELGIPIS

Query:  LETKDALVSSTSKLESRPILTTETSLLHAMKIAAEILKQRTEGRAGLTVVTGSLHAVSMVLSSLHS
        LETKDALVSSTSKLESRPILTTETSLLHAMKIAAEILKQRTEGRAGLTVVTGSLHAVSMVLSSLHS
Subjt:  LETKDALVSSTSKLESRPILTTETSLLHAMKIAAEILKQRTEGRAGLTVVTGSLHAVSMVLSSLHS

A0A6J1E819 dihydrofolate synthetase isoform X1

0.0

85.69

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Query:  MNVFKYHRRYRPQILGGLLLNFLVGEGPSISCRIGSKQCFATHSEDLELTEFMEYLDSLKNYEKLGVPRGAGTDSDDGFDLGRMRRLMERLGNPQSKFKA
        MN+FKYH  +RPQI G LLLN+ VGEGPSIS RIGSKQCF  HSED ++TEFMEYLDSLKNYEKLGVP GAGTDS+DGFDLGRM+RLMERLGNPQSKFKA
Subjt:  MNVFKYHRRYRPQILGGLLLNFLVGEGPSISCRIGSKQCFATHSEDLELTEFMEYLDSLKNYEKLGVPRGAGTDSDDGFDLGRMRRLMERLGNPQSKFKA

Query:  IHIAGTKGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISLGRSGEMVSGKALNSLFKRNKEFLDQSVEFENGRISHFEVLTAMAFSLFAQENVDVA
        IHIAGTKGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISLGRSGEMVSGKALN LFKRNKE LDQSV+ ENGRISHFEVLTAMAFSLFAQENVDVA
Subjt:  IHIAGTKGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISLGRSGEMVSGKALNSLFKRNKEFLDQSVEFENGRISHFEVLTAMAFSLFAQENVDVA

Query:  VIEAGLGGARDATNIICSSRLAAAVITSIGEEHMAALGGSLESIAMAKAGIIKHGCPTILGGPFLPSIECILHDKALSMSSYVISASYPGHRSTIKGVSL
        VIEAGLGGARDATNIICSSRLAAAVITSIGEEHMAALGGSLESIAMAKAGIIKHGCPTILGGPF+P+IECIL DKALSMSS V+SAS PG+RS+IKGVSL
Subjt:  VIEAGLGGARDATNIICSSRLAAAVITSIGEEHMAALGGSLESIAMAKAGIIKHGCPTILGGPFLPSIECILHDKALSMSSYVISASYPGHRSTIKGVSL

Query:  LDGRLCQCCDIVIQIDNEFIELLDVNLRMLGRHQLQNAATATCAILTLRNLGWRISDSSIKTGLEQTFLVGRSHFLSAKEAGVLGLPGATILLDGGAFIF
        L+GRLCQCCD++IQ DNEFIEL DVNLRMLGRHQLQNAATATC ILTLRNLGWRIS++SI++GLE+TFLVGRSHFLSAKEAG+LGLPG  ILLDG     
Subjt:  LDGRLCQCCDIVIQIDNEFIELLDVNLRMLGRHQLQNAATATCAILTLRNLGWRISDSSIKTGLEQTFLVGRSHFLSAKEAGVLGLPGATILLDGGAFIF

Query:  LFITVKFGLLGDEAHTKDSAKALVDTIQMTFPEARLALVVAMASDKDHVGFAREFLQGGKLESIILTEANIGGGKSRTTSAAILRDCWIQAANELGIPIS
                     AHTKDSAKALVDTIQM+FP+A+LALVVAMASDKDH GFA EFLQGGKLESI+L+EANIGG KSRTTSAA+LRDCWIQA+NE+GIPIS
Subjt:  LFITVKFGLLGDEAHTKDSAKALVDTIQMTFPEARLALVVAMASDKDHVGFAREFLQGGKLESIILTEANIGGGKSRTTSAAILRDCWIQAANELGIPIS

Query:  LETKDALVSSTSKLESRPILTTETSLLHAMKIAAEILKQRTEGRAGLTVVTGSLHAVSMVLSSLHS
        LETKDA VSSTSKLE+RP+LTTETSLL A+KIAAEILKQR +GR GL VVTGSLHAVSMVLSSLHS
Subjt:  LETKDALVSSTSKLESRPILTTETSLLHAMKIAAEILKQRTEGRAGLTVVTGSLHAVSMVLSSLHS

A0A6J1J6Z7 dihydrofolate synthetase isoform X1

0.0

83.57

Show/hide

Query:  MNVFKYHRRYRPQILGGLLLNFLVGEGPSISCRIGSKQCFATHSEDLELTEFMEYLDSLKNYEKLGVPRGAGTDSDDGFDLGRMRRLMERLGNPQSKFKA
        MNVFKYH  +R QILG LLLN+ VGEGPSIS RIGSKQCF  HSED ++TEFMEYLDSLKNYEKLGVP GAGTDS+DGFDLGRM+RLMERLGNPQSKFKA
Subjt:  MNVFKYHRRYRPQILGGLLLNFLVGEGPSISCRIGSKQCFATHSEDLELTEFMEYLDSLKNYEKLGVPRGAGTDSDDGFDLGRMRRLMERLGNPQSKFKA

Query:  IHIAGTKGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISLGRSGEMVSGKALNSLFKRNKEFLDQSVEFENGRISHFEVLTAMAFSLFAQENVDVA
        IHIAGTKGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISLGRSGEMVSGKALN LFKRNKE LDQSV+ ENGRISHFEVLTAMAFSLFAQENVDVA
Subjt:  IHIAGTKGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISLGRSGEMVSGKALNSLFKRNKEFLDQSVEFENGRISHFEVLTAMAFSLFAQENVDVA

Query:  VIEAGLGGARDATNIICSSRLAAAVITSIGEEHMAALGGSLESIAMAKAGIIKHGCPTILGGPFLPSIECILHDKALSMSSYVISASYPGHRSTIKGVSL
        VIEAGLGGARDATNIICSS LAAAVITSIGEEHMAALGGSLESIAMAKAGIIKHGCPTILGGPF+P+IECIL DKALSMSS V+SAS PG+RSTIKGVSL
Subjt:  VIEAGLGGARDATNIICSSRLAAAVITSIGEEHMAALGGSLESIAMAKAGIIKHGCPTILGGPFLPSIECILHDKALSMSSYVISASYPGHRSTIKGVSL

Query:  LDGRLCQCCDIVIQIDNEFIELLDVNLRMLGRHQLQNAATATCAILTLRNLGWRISDSSIKTGLEQTFLVGRSHFLSAKEAGVLGLPGATILLDGGAFIF
        L+GRLCQCCD++IQ D+EFIEL DVNLRMLGRHQLQNAATATC ILTLRNLGWRISD+SI++GLE+TFLVGRSHFLSAKEAG+LGLPG TILLDG     
Subjt:  LDGRLCQCCDIVIQIDNEFIELLDVNLRMLGRHQLQNAATATCAILTLRNLGWRISDSSIKTGLEQTFLVGRSHFLSAKEAGVLGLPGATILLDGGAFIF

Query:  LFITVKFGLLGDEAHTKDSAKALVDTIQMTFPEARLALVVAMASDKDHVGFAREFLQGGKLESIILTEANIGGGKSRTTSAAILRDCWIQAANELGIPIS
                     AHTKDSAKALVDTIQM+FP+A+LALVVAMASDKDH GFA EFLQ GKLESI+L+EANIGGGKSRTTSAA+LRDCWIQA+NE+GIP  
Subjt:  LFITVKFGLLGDEAHTKDSAKALVDTIQMTFPEARLALVVAMASDKDHVGFAREFLQGGKLESIILTEANIGGGKSRTTSAAILRDCWIQAANELGIPIS

Query:  LETKDALVSSTSKLESRPILTTETSLLHAMKIAAEILKQRTEGRAGLTVVTGSLHAVSMVLSSLHS
                + TS      +LTTETSLL A+KIAAEILKQRTEGR GL VVTGSLHAVSMVLSSLHS
Subjt:  LETKDALVSSTSKLESRPILTTETSLLHAMKIAAEILKQRTEGRAGLTVVTGSLHAVSMVLSSLHS

SwissProt top hits

e value

%identity

Alignment

A6H751 Folylpolyglutamate synthase, mitochondrial

2.2e-26

35.68

Show/hide

Query:  GEGPSISCRIGSKQCFATHSEDLELTEFMEYLDSLK---NYEKLGVPRGAGTDSDDGFDLGRMRRLMERLG---NPQSKFKAIHIAGTKGKGSTAAFLSN
        G    ++ R G          D+E  + +  L++L+   NY ++ V R  G   D    L  M+  + R G       +   IHI GTKGKGST AF   
Subjt:  GEGPSISCRIGSKQCFATHSEDLELTEFMEYLDSLK---NYEKLGVPRGAGTDSDDGFDLGRMRRLMERLG---NPQSKFKAIHIAGTKGKGSTAAFLSN

Query:  ILRAEGYSVGCYTSPHIETIRERISLGRSGEMVSGKALNSLFKRNKEFLDQSVEFEN--GRISHFEVLTAMAFSLFAQENVDVAVIEAGLGGARDATNII
        ILR+ G   G ++SPH+  +RERI +  +G+ +S +     F R    L+++ +  +      +F  LT MAF +F QE VD+AV+E G+GGA D TNII
Subjt:  ILRAEGYSVGCYTSPHIETIRERISLGRSGEMVSGKALNSLFKRNKEFLDQSVEFEN--GRISHFEVLTAMAFSLFAQENVDVAVIEAGLGGARDATNII

Query:  CSSRLAAAVITSIGEEHMAALGGSLESIAMAKAGIIKHGCP
           +     ITS+G +H   LG ++E IA  K GI K G P
Subjt:  CSSRLAAAVITSIGEEHMAALGGSLESIAMAKAGIIKHGCP

D4GW05 Probable bifunctional folylpolyglutamate synthase/dihydropteroate synthase

1.5e-27

28.86

Show/hide

Query:  MRRLMERLGNPQSKFKAIHIAGTKGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISLGRSGEMVSGKALNSLFKRNKEFLDQSVEFENGRISHFEV
        +RRL+  LG+P      + +AG+ GKGSTA  +  +LR  G  VG YTSPH + +RER+ +   G  +   AL++     K +L +    +   ++ FE 
Subjt:  MRRLMERLGNPQSKFKAIHIAGTKGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISLGRSGEMVSGKALNSLFKRNKEFLDQSVEFENGRISHFEV

Query:  LTAMAFSLFAQENVDVAVIEAGLGGARDATNIICSSRLAAAVITSIGEEHMAALGGSLESIAMAKAGIIKHGCPTILG--GPFLPSI-----ECILHDKA
        +TA+A   F +  VDVAV+E G+GG  DAT+ +      A+ +T++  EH A LG ++  IA  KA +     P + G  G  L  I     + +    A
Subjt:  LTAMAFSLFAQENVDVAVIEAGLGGARDATNIICSSRLAAAVITSIGEEHMAALGGSLESIAMAKAGIIKHGCPTILG--GPFLPSI-----ECILHDKA

Query:  LSMSSYVISASYPGHRSTIKGVSLLDGRLCQCCDIVIQIDNEFIELLDVNLRMLGRHQLQNAATATCAILTLRNLGWRISDSSIKTGLEQTFLVGRSHFL
         + S   +  SY G  +             Q   + ++ D    E LDV + +LG +Q +NA     A+   R +   I   +I  GL      GR   +
Subjt:  LSMSSYVISASYPGHRSTIKGVSLLDGRLCQCCDIVIQIDNEFIELLDVNLRMLGRHQLQNAATATCAILTLRNLGWRISDSSIKTGLEQTFLVGRSHFL

Query:  SAKEAGVLGLPGATILLDGGAFIFLFITVKFGLLGDEAHTKDSAKALVDTIQMTFPEARLALVVAMASDKDH---VGFAREFLQGGKLESIILTEANIGG
          +          T++LDG                  AH  D A A V T+   F    L LV     DKDH   VG   E      + S++  +A+I  
Subjt:  SAKEAGVLGLPGATILLDGGAFIFLFITVKFGLLGDEAHTKDSAKALVDTIQMTFPEARLALVVAMASDKDH---VGFAREFLQGGKLESIILTEANIGG

Query:  GK
        G+
Subjt:  GK

F4JYE9 Dihydrofolate synthetase

4.5e-157

59.66

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Query:  SEDLELTEFMEYLDSLKNYEKLGVPRGAGTDSDDGFDLGRMRRLMERLGNPQSKFKAIHIAGTKGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERIS
        +ED EL +F+ +L+SLKNYEK GVP+GAGTDSDDGFDLGRM+RLM RL NP  K+K +H+AGTKGKGST+AFLSNILRA GYSVGCY+SPHI +I+ERIS
Subjt:  SEDLELTEFMEYLDSLKNYEKLGVPRGAGTDSDDGFDLGRMRRLMERLGNPQSKFKAIHIAGTKGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERIS

Query:  LGRSGEMVSGKALNSLFKRNKEFLDQSVEFENGRISHFEVLTAMAFSLFAQENVDVAVIEAGLGGARDATNIICSSRLAAAVITSIGEEHMAALGGSLES
           +GE VS   LN LF   K  L+QS++ ENG +SHFE+LT +AFSLF +ENVD+AVIEAGLGGARDATN+I SS LAA+VIT+IGEEHMAALGGSLES
Subjt:  LGRSGEMVSGKALNSLFKRNKEFLDQSVEFENGRISHFEVLTAMAFSLFAQENVDVAVIEAGLGGARDATNIICSSRLAAAVITSIGEEHMAALGGSLES

Query:  IAMAKAGIIKHGCPTILGGPFLPSIECILHDKALSMSSYVISASYPGHRSTIKGVSLLDG-RLCQCCDIVIQ---IDNEFIELLDVNLRMLGRHQLQNAA
        IA AK+GIIKHG P +LGGPFLP IE IL  KA S+SS VI AS  G  S+IKG+   +G  LCQ CDIVIQ    D   +EL DVNLRMLG HQLQNA 
Subjt:  IAMAKAGIIKHGCPTILGGPFLPSIECILHDKALSMSSYVISASYPGHRSTIKGVSLLDG-RLCQCCDIVIQ---IDNEFIELLDVNLRMLGRHQLQNAA

Query:  TATCAILTLRNLG-WRISDSSIKTGLEQTFLVGRSHFLSAKEAGVLGLPGATILLDGGAFIFLFITVKFGLLGDEAHTKDSAKALVDTIQMTFPEARLAL
        TATC  L LR+ G  R++D +I+ GLE T L+GRS FL+ KEA  L LPGAT+LLDG                  AHTK+SA+AL + I+  FPE RL  
Subjt:  TATCAILTLRNLG-WRISDSSIKTGLEQTFLVGRSHFLSAKEAGVLGLPGATILLDGGAFIFLFITVKFGLLGDEAHTKDSAKALVDTIQMTFPEARLAL

Query:  VVAMASDKDHVGFAREFLQGGKLESIILTEANIGGGKSRTTSAAILRDCWIQAANELGIPISLETKDALVSSTSKLESRPILTTET-SLLHAMKIAAEIL
        VVAMASDKDHV FA+E L G K E++ILTEA+IGGGK R+T +++L++ WI+AA+ELG                   SR +  +E  ++L ++K+A +IL
Subjt:  VVAMASDKDHVGFAREFLQGGKLESIILTEANIGGGKSRTTSAAILRDCWIQAANELGIPISLETKDALVSSTSKLESRPILTTET-SLLHAMKIAAEIL

Query:  K-QRTEGRAGLTVVTGSLHAVSMVLSSL
            T   +G+ +VTGSLH VS VL+SL
Subjt:  K-QRTEGRAGLTVVTGSLHAVSMVLSSL

P15925 Folylpolyglutamate synthase

1.8e-28

26.73

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Query:  LELTEFMEYLDSLKNYEKLGVPRGAGTDSDDGFDLGRMRRLMERLGNPQSKFKAIHIAGTKGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISLGR
        +  TE + Y+ S     K G             D  R+  L+  LGNPQ + + IH+ GT GKGS A  ++++L A G +VG YTSP I    ERI +  
Subjt:  LELTEFMEYLDSLKNYEKLGVPRGAGTDSDDGFDLGRMRRLMERLGNPQSKFKAIHIAGTKGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISLGR

Query:  SGEMVSGKALNSLFKRNKEFLDQSVEFE-NGRISHFEVLTAMAFSLFAQENVDVAVIEAGLGGARDATNIICSSRLAAAVITSIGEEHMAALGGSLESIA
          E +   AL +     +  L++  + + +  ++ FE +TA+ +  F Q  VDVAVIE G+GG  D+TN+I       +V+T +  +H   LG ++ +IA
Subjt:  SGEMVSGKALNSLFKRNKEFLDQSVEFE-NGRISHFEVLTAMAFSLFAQENVDVAVIEAGLGGARDATNIICSSRLAAAVITSIGEEHMAALGGSLESIA

Query:  MAKAGIIKHGCPTILGGPFLPSIECILHDKALSMSSYVI----SASYP-------GHRSTIKGVSLLDGRLCQCCDIVIQIDNEFIELLDVNLRMLGRHQ
          KAGIIK G P + G   +P    ++  K  +  S  +      S P       G R T +     DGR+                  D+ + ++G +Q
Subjt:  MAKAGIIKHGCPTILGGPFLPSIECILHDKALSMSSYVI----SASYP-------GHRSTIKGVSLLDGRLCQCCDIVIQIDNEFIELLDVNLRMLGRHQ

Query:  LQNAATA-TCAILTLRNLGWRISDSSIKTGLEQTFLVGRSHFLSAKEAGVLGLPGATILLDGGAFIFLFITVKFGLLGDEAHTKDSAKALVDTIQMTFPE
         +N A A   A +  +   W ++  +I+ GL  +    R   +S             I++DG                  AH  D    L+  ++  F +
Subjt:  LQNAATA-TCAILTLRNLGWRISDSSIKTGLEQTFLVGRSHFLSAKEAGVLGLPGATILLDGGAFIFLFITVKFGLLGDEAHTKDSAKALVDTIQMTFPE

Query:  ARLALVVAMASDKDHVGFA
          + ++  + +DKD+   A
Subjt:  ARLALVVAMASDKDHVGFA

Q05865 Dihydrofolate synthase/folylpolyglutamate synthase

4.5e-40

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Query:  LGRMRRLMERLGNPQSKFKAIHIAGTKGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISLGRSGEMVSGKALNSLFKRNKEFLDQSVEFENGRISH
        LGRM++LM RLG+P+ K +A H+AGT GKGST AF+ ++L+  GY+VG +TSP+I T  ERIS+  +G  +S +   +L  + K  ++   + E G+ + 
Subjt:  LGRMRRLMERLGNPQSKFKAIHIAGTKGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISLGRSGEMVSGKALNSLFKRNKEFLDQSVEFENGRISH

Query:  FEVLTAMAFSLFAQ-ENVDVAVIEAGLGGARDATNIICSSRLAAAVITSIGEEHMAALGGSLESIAMAKAGIIKHGCPTILGGPFLPSIECILHDKALSM
        FE++TA AF  FA+   VD  + E GLGG  D+TN++        VITSIG +HM  LG ++E IA  KAGIIK G P +       +++ I H+     
Subjt:  FEVLTAMAFSLFAQ-ENVDVAVIEAGLGGARDATNIICSSRLAAAVITSIGEEHMAALGGSLESIAMAKAGIIKHGCPTILGGPFLPSIECILHDKALSM

Query:  SSYVISASYPGHRSTIKGVSLLDGRLCQCCDIVIQIDNEFIELLDVNLRMLGRHQLQNAATATCAI--LTLRNLGWRISDSSIKTGLEQTFLVGRSHFLS
        + +           ++    ++                E     D+   ++G HQ QNAA +  A   L   N+   ISD ++++GL +    GR   + 
Subjt:  SSYVISASYPGHRSTIKGVSLLDGRLCQCCDIVIQIDNEFIELLDVNLRMLGRHQLQNAATATCAI--LTLRNLGWRISDSSIKTGLEQTFLVGRSHFLS

Query:  AKEAGVLGLPGATILLDGGAFIFLFITVKFGLLGDEAHTKDSAKALVDTIQMTFPEARLALVVAMASDKDH
                     + LDG                  AH ++  + L +T++  F  +R+++V +   DK +
Subjt:  AKEAGVLGLPGATILLDGGAFIFLFITVKFGLLGDEAHTKDSAKALVDTIQMTFPEARLALVVAMASDKDH

Arabidopsis top hits

e value

%identity

Alignment

AT3G55630.2 DHFS-FPGS homolog D

2.1e-24

33.09

Show/hide

Query:  SKFKAIHIAGTKGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISLGRSGEMVSGKALNSLFKRNKEFLDQSVEFENGRISHFEVLTAMAFSLFAQE
        S+ K IH+AGTKGKGST  F  +ILR  G   G +TSPH+  +RER  L  +G  +S +   + F      L +    E    ++F  L  +AF +F  E
Subjt:  SKFKAIHIAGTKGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISLGRSGEMVSGKALNSLFKRNKEFLDQSVEFENGRISHFEVLTAMAFSLFAQE

Query:  NVDVAVIEAGLGGARDATNIICSSRLAAAVITSIGEEHMAALGGSLESIAMAKAGIIKHGCPTILGGPFLPSIECILHDKALSMSSYVISASYPGHRSTI
         VDV ++E GLGG  DATNI    +     I+S+G +HM  LG +L  IA  KAGI K G         +P+      D+A+ + +   S          
Subjt:  NVDVAVIEAGLGGARDATNIICSSRLAAAVITSIGEEHMAALGGSLESIAMAKAGIIKHGCPTILGGPFLPSIECILHDKALSMSSYVISASYPGHRSTI

Query:  KGVSLLDGRLCQCCDIVIQIDNEFIELLDVNLR--MLGRHQLQNAATATCAILT-LRNLGWRISDSSIKTGLEQT
                         ++++ + +E LD + R  + G HQ  NA  A     T L+ +G  I D   K GL+QT
Subjt:  KGVSLLDGRLCQCCDIVIQIDNEFIELLDVNLR--MLGRHQLQNAATATCAILT-LRNLGWRISDSSIKTGLEQT

AT3G55630.3 DHFS-FPGS homolog D

7.2e-25

33.09

Show/hide

Query:  SKFKAIHIAGTKGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISLGRSGEMVSGKALNSLFKRNKEFLDQSVEFENGRISHFEVLTAMAFSLFAQE
        S+ K IH+AGTKGKGST  F  +ILR  G   G +TSPH+  +RER  L  +G  +S +   + F      L +    E    ++F  L  +AF +F  E
Subjt:  SKFKAIHIAGTKGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISLGRSGEMVSGKALNSLFKRNKEFLDQSVEFENGRISHFEVLTAMAFSLFAQE

Query:  NVDVAVIEAGLGGARDATNIICSSRLAAAVITSIGEEHMAALGGSLESIAMAKAGIIKHGCPTILGGPFLPSIECILHDKALSMSSYVISASYPGHRSTI
         VDV ++E GLGG  DATN+I   +     I+S+G +HM  LG +L  IA  KAGI K G         +P+      D+A+ + +   S          
Subjt:  NVDVAVIEAGLGGARDATNIICSSRLAAAVITSIGEEHMAALGGSLESIAMAKAGIIKHGCPTILGGPFLPSIECILHDKALSMSSYVISASYPGHRSTI

Query:  KGVSLLDGRLCQCCDIVIQIDNEFIELLDVNLR--MLGRHQLQNAATATCAILT-LRNLGWRISDSSIKTGLEQT
                         ++++ + +E LD + R  + G HQ  NA  A     T L+ +G  I D   K GL+QT
Subjt:  KGVSLLDGRLCQCCDIVIQIDNEFIELLDVNLR--MLGRHQLQNAATATCAILT-LRNLGWRISDSSIKTGLEQT

AT5G05980.1 DHFS-FPGS homolog B

6.1e-24

40.99

Show/hide

Query:  KFKAIHIAGTKGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISLGRSGEMVSGKALNSLFKRNKEFLDQSVEFENGRISHFEVLTAMAFSLFAQEN
        K   IH+AGTKGKGST  F  +I+R  G+  G +TSPH+  +RER  L   G  +S +     F      L +    E    ++F  L  +AF +FA E 
Subjt:  KFKAIHIAGTKGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISLGRSGEMVSGKALNSLFKRNKEFLDQSVEFENGRISHFEVLTAMAFSLFAQEN

Query:  VDVAVIEAGLGGARDATNIICSSRLAAAVITSIGEEHMAALGGSLESIAMAKAGIIKHGCP
        VD A++E GLGG  DATN +   +     I+S+G +HM  LG +L  IA  KAGI K G P
Subjt:  VDVAVIEAGLGGARDATNIICSSRLAAAVITSIGEEHMAALGGSLESIAMAKAGIIKHGCP

AT5G05980.2 DHFS-FPGS homolog B

6.1e-24

40.99

Show/hide

Query:  KFKAIHIAGTKGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISLGRSGEMVSGKALNSLFKRNKEFLDQSVEFENGRISHFEVLTAMAFSLFAQEN
        K   IH+AGTKGKGST  F  +I+R  G+  G +TSPH+  +RER  L   G  +S +     F      L +    E    ++F  L  +AF +FA E 
Subjt:  KFKAIHIAGTKGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISLGRSGEMVSGKALNSLFKRNKEFLDQSVEFENGRISHFEVLTAMAFSLFAQEN

Query:  VDVAVIEAGLGGARDATNIICSSRLAAAVITSIGEEHMAALGGSLESIAMAKAGIIKHGCP
        VD A++E GLGG  DATN +   +     I+S+G +HM  LG +L  IA  KAGI K G P
Subjt:  VDVAVIEAGLGGARDATNIICSSRLAAAVITSIGEEHMAALGGSLESIAMAKAGIIKHGCP

AT5G41480.1 Folylpolyglutamate synthetase family protein

3.2e-158

59.66

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Query:  SEDLELTEFMEYLDSLKNYEKLGVPRGAGTDSDDGFDLGRMRRLMERLGNPQSKFKAIHIAGTKGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERIS
        +ED EL +F+ +L+SLKNYEK GVP+GAGTDSDDGFDLGRM+RLM RL NP  K+K +H+AGTKGKGST+AFLSNILRA GYSVGCY+SPHI +I+ERIS
Subjt:  SEDLELTEFMEYLDSLKNYEKLGVPRGAGTDSDDGFDLGRMRRLMERLGNPQSKFKAIHIAGTKGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERIS

Query:  LGRSGEMVSGKALNSLFKRNKEFLDQSVEFENGRISHFEVLTAMAFSLFAQENVDVAVIEAGLGGARDATNIICSSRLAAAVITSIGEEHMAALGGSLES
           +GE VS   LN LF   K  L+QS++ ENG +SHFE+LT +AFSLF +ENVD+AVIEAGLGGARDATN+I SS LAA+VIT+IGEEHMAALGGSLES
Subjt:  LGRSGEMVSGKALNSLFKRNKEFLDQSVEFENGRISHFEVLTAMAFSLFAQENVDVAVIEAGLGGARDATNIICSSRLAAAVITSIGEEHMAALGGSLES

Query:  IAMAKAGIIKHGCPTILGGPFLPSIECILHDKALSMSSYVISASYPGHRSTIKGVSLLDG-RLCQCCDIVIQ---IDNEFIELLDVNLRMLGRHQLQNAA
        IA AK+GIIKHG P +LGGPFLP IE IL  KA S+SS VI AS  G  S+IKG+   +G  LCQ CDIVIQ    D   +EL DVNLRMLG HQLQNA 
Subjt:  IAMAKAGIIKHGCPTILGGPFLPSIECILHDKALSMSSYVISASYPGHRSTIKGVSLLDG-RLCQCCDIVIQ---IDNEFIELLDVNLRMLGRHQLQNAA

Query:  TATCAILTLRNLG-WRISDSSIKTGLEQTFLVGRSHFLSAKEAGVLGLPGATILLDGGAFIFLFITVKFGLLGDEAHTKDSAKALVDTIQMTFPEARLAL
        TATC  L LR+ G  R++D +I+ GLE T L+GRS FL+ KEA  L LPGAT+LLDG                  AHTK+SA+AL + I+  FPE RL  
Subjt:  TATCAILTLRNLG-WRISDSSIKTGLEQTFLVGRSHFLSAKEAGVLGLPGATILLDGGAFIFLFITVKFGLLGDEAHTKDSAKALVDTIQMTFPEARLAL

Query:  VVAMASDKDHVGFAREFLQGGKLESIILTEANIGGGKSRTTSAAILRDCWIQAANELGIPISLETKDALVSSTSKLESRPILTTET-SLLHAMKIAAEIL
        VVAMASDKDHV FA+E L G K E++ILTEA+IGGGK R+T +++L++ WI+AA+ELG                   SR +  +E  ++L ++K+A +IL
Subjt:  VVAMASDKDHVGFAREFLQGGKLESIILTEANIGGGKSRTTSAAILRDCWIQAANELGIPISLETKDALVSSTSKLESRPILTTET-SLLHAMKIAAEIL

Query:  K-QRTEGRAGLTVVTGSLHAVSMVLSSL
            T   +G+ +VTGSLH VS VL+SL
Subjt:  K-QRTEGRAGLTVVTGSLHAVSMVLSSL

Sequences

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CDS sequence

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ATTTTTATAGCCGAGGATTGTCGCAAGTTTCGCTCTGTTAGTGTTGGCCACTCTTCCAGCTCGTACTTCGCACTGCCTACTAGTTTTTCCCCAAGAAAAAAAATATTCTA
TGATTTCAGAATGAATGTCTTCAAATATCATCGCCGTTATCGCCCACAAATTCTCGGAGGGCTTCTCCTAAATTTTTTGGTGGGTGAAGGGCCTTCTATCAGTTGCAGAA
TAGGGTCTAAACAATGCTTTGCCACCCACTCAGAAGATCTAGAGCTAACGGAATTCATGGAATACTTGGATTCCTTGAAGAACTACGAGAAGTTGGGTGTGCCCAGAGGC
GCCGGGACGGATTCTGATGATGGGTTCGATCTCGGAAGGATGAGAAGACTGATGGAGCGGCTGGGTAATCCACAATCCAAGTTTAAGGCCATTCACATTGCGGGAACCAA
GGGAAAAGGGTCGACTGCTGCCTTCCTGTCTAACATTTTACGAGCAGAGGGATACTCTGTTGGCTGTTATACTAGTCCTCATATTGAAACTATAAGGGAACGTATTTCAC
TCGGAAGATCTGGAGAGATGGTCTCTGGGAAGGCACTAAACTCTCTTTTCAAAAGGAACAAAGAGTTTCTTGACCAGTCAGTTGAATTTGAAAATGGGCGTATTAGTCAT
TTCGAGGTCCTTACTGCTATGGCATTCTCACTCTTTGCACAAGAGAATGTTGATGTTGCAGTCATTGAGGCTGGACTTGGTGGTGCACGAGATGCAACAAACATAATTTG
CAGCTCTAGACTTGCTGCTGCAGTCATAACTTCAATTGGAGAGGAACACATGGCTGCCCTAGGTGGCTCTTTGGAGAGCATTGCAATGGCAAAGGCTGGAATAATTAAAC
ACGGTTGTCCGACTATATTGGGTGGTCCTTTCCTTCCAAGTATTGAGTGCATTCTTCACGATAAAGCATTATCCATGTCTTCGTATGTAATATCTGCCTCATATCCTGGA
CATAGAAGTACTATAAAAGGTGTAAGCCTGCTTGATGGAAGACTTTGCCAATGCTGCGACATAGTAATTCAAATAGACAATGAATTCATTGAGTTATTGGATGTCAACCT
CCGCATGCTTGGACGTCATCAACTTCAGAACGCAGCAACTGCAACTTGTGCTATTCTCACTCTCCGCAATTTAGGTTGGAGAATTTCGGATTCCTCAATTAAGACTGGAC
TAGAGCAAACATTCTTGGTCGGTAGGAGCCATTTCTTATCAGCAAAGGAGGCTGGGGTTCTTGGACTACCTGGAGCAACAATATTGCTGGATGGAGGTGCATTCATATTT
CTGTTTATTACAGTCAAATTTGGTTTGTTGGGAGATGAGGCCCACACCAAAGACTCTGCCAAAGCATTAGTGGACACCATTCAGATGACTTTTCCGGAGGCACGGTTGGC
TCTCGTGGTTGCAATGGCTAGCGATAAGGATCACGTTGGTTTTGCCAGAGAATTTCTTCAAGGTGGAAAATTGGAGTCCATTATCTTGACTGAAGCTAATATTGGTGGAG
GCAAATCAAGGACAACTTCAGCTGCCATTCTAAGAGACTGCTGGATCCAAGCAGCCAATGAATTGGGGATCCCAATTTCTCTAGAAACTAAAGATGCACTGGTCTCCTCC
ACAAGCAAACTCGAAAGCAGACCGATATTAACTACCGAGACCTCGTTATTACATGCCATGAAAATTGCTGCTGAGATTCTCAAGCAGAGAACGGAAGGGCGAGCAGGTCT
TACCGTAGTAACTGGGTCGCTGCATGCTGTTTCAATGGTGTTATCTTCTCTCCATTCTTGA

mRNA sequence

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AATTTTTATAGCCGAGGATTGTCGCAAGTTTCGCTCTGTTAGTGTTGGCCACTCTTCCAGCTCGTACTTCGCACTGCCTACTAGTTTTTCCCCAAGAAAAAAAATATTCT
ATGATTTCAGAATGAATGTCTTCAAATATCATCGCCGTTATCGCCCACAAATTCTCGGAGGGCTTCTCCTAAATTTTTTGGTGGGTGAAGGGCCTTCTATCAGTTGCAGA
ATAGGGTCTAAACAATGCTTTGCCACCCACTCAGAAGATCTAGAGCTAACGGAATTCATGGAATACTTGGATTCCTTGAAGAACTACGAGAAGTTGGGTGTGCCCAGAGG
CGCCGGGACGGATTCTGATGATGGGTTCGATCTCGGAAGGATGAGAAGACTGATGGAGCGGCTGGGTAATCCACAATCCAAGTTTAAGGCCATTCACATTGCGGGAACCA
AGGGAAAAGGGTCGACTGCTGCCTTCCTGTCTAACATTTTACGAGCAGAGGGATACTCTGTTGGCTGTTATACTAGTCCTCATATTGAAACTATAAGGGAACGTATTTCA
CTCGGAAGATCTGGAGAGATGGTCTCTGGGAAGGCACTAAACTCTCTTTTCAAAAGGAACAAAGAGTTTCTTGACCAGTCAGTTGAATTTGAAAATGGGCGTATTAGTCA
TTTCGAGGTCCTTACTGCTATGGCATTCTCACTCTTTGCACAAGAGAATGTTGATGTTGCAGTCATTGAGGCTGGACTTGGTGGTGCACGAGATGCAACAAACATAATTT
GCAGCTCTAGACTTGCTGCTGCAGTCATAACTTCAATTGGAGAGGAACACATGGCTGCCCTAGGTGGCTCTTTGGAGAGCATTGCAATGGCAAAGGCTGGAATAATTAAA
CACGGTTGTCCGACTATATTGGGTGGTCCTTTCCTTCCAAGTATTGAGTGCATTCTTCACGATAAAGCATTATCCATGTCTTCGTATGTAATATCTGCCTCATATCCTGG
ACATAGAAGTACTATAAAAGGTGTAAGCCTGCTTGATGGAAGACTTTGCCAATGCTGCGACATAGTAATTCAAATAGACAATGAATTCATTGAGTTATTGGATGTCAACC
TCCGCATGCTTGGACGTCATCAACTTCAGAACGCAGCAACTGCAACTTGTGCTATTCTCACTCTCCGCAATTTAGGTTGGAGAATTTCGGATTCCTCAATTAAGACTGGA
CTAGAGCAAACATTCTTGGTCGGTAGGAGCCATTTCTTATCAGCAAAGGAGGCTGGGGTTCTTGGACTACCTGGAGCAACAATATTGCTGGATGGAGGTGCATTCATATT
TCTGTTTATTACAGTCAAATTTGGTTTGTTGGGAGATGAGGCCCACACCAAAGACTCTGCCAAAGCATTAGTGGACACCATTCAGATGACTTTTCCGGAGGCACGGTTGG
CTCTCGTGGTTGCAATGGCTAGCGATAAGGATCACGTTGGTTTTGCCAGAGAATTTCTTCAAGGTGGAAAATTGGAGTCCATTATCTTGACTGAAGCTAATATTGGTGGA
GGCAAATCAAGGACAACTTCAGCTGCCATTCTAAGAGACTGCTGGATCCAAGCAGCCAATGAATTGGGGATCCCAATTTCTCTAGAAACTAAAGATGCACTGGTCTCCTC
CACAAGCAAACTCGAAAGCAGACCGATATTAACTACCGAGACCTCGTTATTACATGCCATGAAAATTGCTGCTGAGATTCTCAAGCAGAGAACGGAAGGGCGAGCAGGTC
TTACCGTAGTAACTGGGTCGCTGCATGCTGTTTCAATGGTGTTATCTTCTCTCCATTCTTGAAGTAGTTACATATGAAAGCACTTCATTTGGATGTACTTTCAAGCAAAG
TTCCCGAGTCTAAAAATCATTGTGGTAGAATGTTTCCCATAAATTCAATGAGGTGTAAACTTAATGGCACAGAAAAGTAATAAAATTTGGTTCCATTTATGGTCAA

Protein sequence

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IFIAEDCRKFRSVSVGHSSSSYFALPTSFSPRKKIFYDFRMNVFKYHRRYRPQILGGLLLNFLVGEGPSISCRIGSKQCFATHSEDLELTEFMEYLDSLKNYEKLGVPRG
AGTDSDDGFDLGRMRRLMERLGNPQSKFKAIHIAGTKGKGSTAAFLSNILRAEGYSVGCYTSPHIETIRERISLGRSGEMVSGKALNSLFKRNKEFLDQSVEFENGRISH
FEVLTAMAFSLFAQENVDVAVIEAGLGGARDATNIICSSRLAAAVITSIGEEHMAALGGSLESIAMAKAGIIKHGCPTILGGPFLPSIECILHDKALSMSSYVISASYPG
HRSTIKGVSLLDGRLCQCCDIVIQIDNEFIELLDVNLRMLGRHQLQNAATATCAILTLRNLGWRISDSSIKTGLEQTFLVGRSHFLSAKEAGVLGLPGATILLDGGAFIF
LFITVKFGLLGDEAHTKDSAKALVDTIQMTFPEARLALVVAMASDKDHVGFAREFLQGGKLESIILTEANIGGGKSRTTSAAILRDCWIQAANELGIPISLETKDALVSS
TSKLESRPILTTETSLLHAMKIAAEILKQRTEGRAGLTVVTGSLHAVSMVLSSLHS

MC10g0080 (gene) of Bitter gourd (Dali-11) v1 genome