CuGenDBv2

Gene ID	MELO3C021680
Organism	Cucumis melo DHL92 (Melon (DHL92) v4)
Description	BAG domain-containing protein
Genome location	chr12:15258053..15258981
RNA-Seq Expression	MELO3C021680
Synteny	MELO3C021680
Gene Ontology terms	GO:0051087 - chaperone binding (molecular function)
InterPro domains	IPR000048 - IQ motif, EF-hand binding site IPR003103 - BAG domain IPR036533 - BAG domain superfamily IPR040400 - BAG family molecular chaperone regulator 5/6/7/8

Homology

Show/hide homology

GenBank top hits

e value

%identity

Alignment

KAG7019394.1 BAG family molecular chaperone regulator 5, mitochondrial, partial [Cucurbita argyrosperma subsp. argyrosperma]

5.4e-88

85.29

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Query:  MNTTSFYYTTAT-----TSFSHSFHNDHSTPPNSTSILIQPSPLLQSSSPAASKIQAAYRSHRIRNLFKTIAAVDREADQIQTLIQRQETVDAVRSNELE
        MN+T FYY TAT      SFS+S HN HSTPPNST +L+QPSP     S AA+KIQAAYRSHRIR+L+KTIAAVDREADQIQ LIQRQETVDAVRSN+LE
Subjt:  MNTTSFYYTTAT-----TSFSHSFHNDHSTPPNSTSILIQPSPLLQSSSPAASKIQAAYRSHRIRNLFKTIAAVDREADQIQTLIQRQETVDAVRSNELE

Query:  KLRMNEALMSLLLRLDSVPGIDPAVREARRKVSRRIVGLQEILDAVSEAKVDFNGWDCNGLVRNWDETVAEMEAEVCRERGGDEMERFCAQYLGFRCFQR
        KLRMNEALMS+LLRLDSVPGIDPAVREARRKVSRRIVGLQEILDAVSEAKVDFNGWDC+G VRNWDET+AEMEAEVCRERGGDEMERFCAQYLGFRCFQR
Subjt:  KLRMNEALMSLLLRLDSVPGIDPAVREARRKVSRRIVGLQEILDAVSEAKVDFNGWDCNGLVRNWDETVAEMEAEVCRERGGDEMERFCAQYLGFRCFQR

Query:  FLSG
        FLSG
Subjt:  FLSG

XP_016902348.1 PREDICTED: BAG family molecular chaperone regulator 5, mitochondrial [Cucumis melo]

4.1e-104

100

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Query:  MNTTSFYYTTATTSFSHSFHNDHSTPPNSTSILIQPSPLLQSSSPAASKIQAAYRSHRIRNLFKTIAAVDREADQIQTLIQRQETVDAVRSNELEKLRMN
        MNTTSFYYTTATTSFSHSFHNDHSTPPNSTSILIQPSPLLQSSSPAASKIQAAYRSHRIRNLFKTIAAVDREADQIQTLIQRQETVDAVRSNELEKLRMN
Subjt:  MNTTSFYYTTATTSFSHSFHNDHSTPPNSTSILIQPSPLLQSSSPAASKIQAAYRSHRIRNLFKTIAAVDREADQIQTLIQRQETVDAVRSNELEKLRMN

Query:  EALMSLLLRLDSVPGIDPAVREARRKVSRRIVGLQEILDAVSEAKVDFNGWDCNGLVRNWDETVAEMEAEVCRERGGDEMERFCAQYLGFRCFQRFLSGF
        EALMSLLLRLDSVPGIDPAVREARRKVSRRIVGLQEILDAVSEAKVDFNGWDCNGLVRNWDETVAEMEAEVCRERGGDEMERFCAQYLGFRCFQRFLSGF
Subjt:  EALMSLLLRLDSVPGIDPAVREARRKVSRRIVGLQEILDAVSEAKVDFNGWDCNGLVRNWDETVAEMEAEVCRERGGDEMERFCAQYLGFRCFQRFLSGF

XP_022927383.1 BAG family molecular chaperone regulator 5, mitochondrial [Cucurbita moschata]

5.4e-88

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Query:  MNTTSFYYTTAT-TSFSHSFHNDHSTPPNSTSILIQPSPLLQSSSPAASKIQAAYRSHRIRNLFKTIAAVDREADQIQTLIQRQETVDAVRSNELEKLRM
        MN TSFYY TAT T+FS+S H  HSTPPNST +L+QPSP     S AA+KIQAAYRSHRIR+L+KTIAAVDREADQIQ LIQRQETVDAVRSN+LEKLRM
Subjt:  MNTTSFYYTTAT-TSFSHSFHNDHSTPPNSTSILIQPSPLLQSSSPAASKIQAAYRSHRIRNLFKTIAAVDREADQIQTLIQRQETVDAVRSNELEKLRM

Query:  NEALMSLLLRLDSVPGIDPAVREARRKVSRRIVGLQEILDAVSEAKVDFNGWDCNGLVRNWDETVAEMEAEVCRERGGDEMERFCAQYLGFRCFQRFLSG
        NEALMS+LLRLDSVPGIDPAVREARRKVSRRIVGLQEILDAVSEAKVDFNGWDC+G VRNWDET+AEMEAEVCRERGGDEMERFCAQYLGFRCFQRFLSG
Subjt:  NEALMSLLLRLDSVPGIDPAVREARRKVSRRIVGLQEILDAVSEAKVDFNGWDCNGLVRNWDETVAEMEAEVCRERGGDEMERFCAQYLGFRCFQRFLSG

XP_031744543.1 BAG family molecular chaperone regulator 5, mitochondrial isoform X1 [Cucumis sativus]

6.8e-91

92.46

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Query:  TTSFYYTTATTSFSHSFHN--DHSTPPNSTSILIQPSPLLQSSSPAASKIQAAYRSHRIRNLFKTIAAVDREADQIQTLIQRQETVDAVRSNELEKLRMN
        TTSFYY   TTSFSHSFHN  DHSTPPN T ILIQP PLL SS  AASKIQAAYRSHRIRNLFKTIAAVD EADQIQTLIQRQETVDAVRSN+LEKLRMN
Subjt:  TTSFYYTTATTSFSHSFHN--DHSTPPNSTSILIQPSPLLQSSSPAASKIQAAYRSHRIRNLFKTIAAVDREADQIQTLIQRQETVDAVRSNELEKLRMN

Query:  EALMSLLLRLDSVPGIDPAVREARRKVSRRIVGLQEILDAVSEAKVDFNGWDCNGLVRNWDETVAEMEAEVCRERGGDEMERFCAQYLGFRCFQRFLSG
        EALM+LLLRLDSVPGIDPAVREARRKVSRRIVGLQEILDAVSEAKVDFNGWDC+GLVRNWDETVAEMEAEVCRERGGDEMERFCAQYLGFRCFQRFLSG
Subjt:  EALMSLLLRLDSVPGIDPAVREARRKVSRRIVGLQEILDAVSEAKVDFNGWDCNGLVRNWDETVAEMEAEVCRERGGDEMERFCAQYLGFRCFQRFLSG

XP_038894826.1 BAG family molecular chaperone regulator 5, mitochondrial [Benincasa hispida]

4.0e-91

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Query:  MNTTSFYYTTATTSFSHSFHNDHSTPPNSTSILIQP-SPLLQSSSPAASKIQAAYRSHRIRNLFKTIAAVDREADQIQTLIQRQETVDAVRSNELEKLRM
        MNTTSFYY+T TTSFSHSFHNDHSTPPNST+ILIQP  P LQSS  AA+KIQAAYRSHRIRNLFKTI AVDREADQIQ+LIQRQETVDAVRSNELEKL+M
Subjt:  MNTTSFYYTTATTSFSHSFHNDHSTPPNSTSILIQP-SPLLQSSSPAASKIQAAYRSHRIRNLFKTIAAVDREADQIQTLIQRQETVDAVRSNELEKLRM

Query:  NEALMSLLLRLDSVPGIDPAVREARRKVSRRIVGLQEILDAVSEAKVDFNGWDCNGLVRNWDETVAEMEAEVCRERGGDEMERFCAQYLGFRCFQRFLSG
        NEALMSLLLRLDSVPGID AVREARRKVSRRIVGLQEILDAVSEAKVDFNGWDC+G VRNWDETVAEMEAEVCRERGGDEMERFCAQYLGFRCF+RFLSG
Subjt:  NEALMSLLLRLDSVPGIDPAVREARRKVSRRIVGLQEILDAVSEAKVDFNGWDCNGLVRNWDETVAEMEAEVCRERGGDEMERFCAQYLGFRCFQRFLSG

TrEMBL top hits

e value

%identity

Alignment

A0A0A0LTG4 BAG domain-containing protein

3.3e-91

92.46

Show/hide

Query:  TTSFYYTTATTSFSHSFHN--DHSTPPNSTSILIQPSPLLQSSSPAASKIQAAYRSHRIRNLFKTIAAVDREADQIQTLIQRQETVDAVRSNELEKLRMN
        TTSFYY   TTSFSHSFHN  DHSTPPN T ILIQP PLL SS  AASKIQAAYRSHRIRNLFKTIAAVD EADQIQTLIQRQETVDAVRSN+LEKLRMN
Subjt:  TTSFYYTTATTSFSHSFHN--DHSTPPNSTSILIQPSPLLQSSSPAASKIQAAYRSHRIRNLFKTIAAVDREADQIQTLIQRQETVDAVRSNELEKLRMN

Query:  EALMSLLLRLDSVPGIDPAVREARRKVSRRIVGLQEILDAVSEAKVDFNGWDCNGLVRNWDETVAEMEAEVCRERGGDEMERFCAQYLGFRCFQRFLSG
        EALM+LLLRLDSVPGIDPAVREARRKVSRRIVGLQEILDAVSEAKVDFNGWDC+GLVRNWDETVAEMEAEVCRERGGDEMERFCAQYLGFRCFQRFLSG
Subjt:  EALMSLLLRLDSVPGIDPAVREARRKVSRRIVGLQEILDAVSEAKVDFNGWDCNGLVRNWDETVAEMEAEVCRERGGDEMERFCAQYLGFRCFQRFLSG

A0A1S4E297 BAG family molecular chaperone regulator 5, mitochondrial

2.0e-104

100

Show/hide

Query:  MNTTSFYYTTATTSFSHSFHNDHSTPPNSTSILIQPSPLLQSSSPAASKIQAAYRSHRIRNLFKTIAAVDREADQIQTLIQRQETVDAVRSNELEKLRMN
        MNTTSFYYTTATTSFSHSFHNDHSTPPNSTSILIQPSPLLQSSSPAASKIQAAYRSHRIRNLFKTIAAVDREADQIQTLIQRQETVDAVRSNELEKLRMN
Subjt:  MNTTSFYYTTATTSFSHSFHNDHSTPPNSTSILIQPSPLLQSSSPAASKIQAAYRSHRIRNLFKTIAAVDREADQIQTLIQRQETVDAVRSNELEKLRMN

Query:  EALMSLLLRLDSVPGIDPAVREARRKVSRRIVGLQEILDAVSEAKVDFNGWDCNGLVRNWDETVAEMEAEVCRERGGDEMERFCAQYLGFRCFQRFLSGF
        EALMSLLLRLDSVPGIDPAVREARRKVSRRIVGLQEILDAVSEAKVDFNGWDCNGLVRNWDETVAEMEAEVCRERGGDEMERFCAQYLGFRCFQRFLSGF
Subjt:  EALMSLLLRLDSVPGIDPAVREARRKVSRRIVGLQEILDAVSEAKVDFNGWDCNGLVRNWDETVAEMEAEVCRERGGDEMERFCAQYLGFRCFQRFLSGF

A0A5A7V387 BAG family molecular chaperone regulator 5

2.0e-104

100

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Query:  MNTTSFYYTTATTSFSHSFHNDHSTPPNSTSILIQPSPLLQSSSPAASKIQAAYRSHRIRNLFKTIAAVDREADQIQTLIQRQETVDAVRSNELEKLRMN
        MNTTSFYYTTATTSFSHSFHNDHSTPPNSTSILIQPSPLLQSSSPAASKIQAAYRSHRIRNLFKTIAAVDREADQIQTLIQRQETVDAVRSNELEKLRMN
Subjt:  MNTTSFYYTTATTSFSHSFHNDHSTPPNSTSILIQPSPLLQSSSPAASKIQAAYRSHRIRNLFKTIAAVDREADQIQTLIQRQETVDAVRSNELEKLRMN

Query:  EALMSLLLRLDSVPGIDPAVREARRKVSRRIVGLQEILDAVSEAKVDFNGWDCNGLVRNWDETVAEMEAEVCRERGGDEMERFCAQYLGFRCFQRFLSGF
        EALMSLLLRLDSVPGIDPAVREARRKVSRRIVGLQEILDAVSEAKVDFNGWDCNGLVRNWDETVAEMEAEVCRERGGDEMERFCAQYLGFRCFQRFLSGF
Subjt:  EALMSLLLRLDSVPGIDPAVREARRKVSRRIVGLQEILDAVSEAKVDFNGWDCNGLVRNWDETVAEMEAEVCRERGGDEMERFCAQYLGFRCFQRFLSGF

A0A6J1EKU8 BAG family molecular chaperone regulator 5, mitochondrial

2.6e-88

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Query:  MNTTSFYYTTAT-TSFSHSFHNDHSTPPNSTSILIQPSPLLQSSSPAASKIQAAYRSHRIRNLFKTIAAVDREADQIQTLIQRQETVDAVRSNELEKLRM
        MN TSFYY TAT T+FS+S H  HSTPPNST +L+QPSP     S AA+KIQAAYRSHRIR+L+KTIAAVDREADQIQ LIQRQETVDAVRSN+LEKLRM
Subjt:  MNTTSFYYTTAT-TSFSHSFHNDHSTPPNSTSILIQPSPLLQSSSPAASKIQAAYRSHRIRNLFKTIAAVDREADQIQTLIQRQETVDAVRSNELEKLRM

Query:  NEALMSLLLRLDSVPGIDPAVREARRKVSRRIVGLQEILDAVSEAKVDFNGWDCNGLVRNWDETVAEMEAEVCRERGGDEMERFCAQYLGFRCFQRFLSG
        NEALMS+LLRLDSVPGIDPAVREARRKVSRRIVGLQEILDAVSEAKVDFNGWDC+G VRNWDET+AEMEAEVCRERGGDEMERFCAQYLGFRCFQRFLSG
Subjt:  NEALMSLLLRLDSVPGIDPAVREARRKVSRRIVGLQEILDAVSEAKVDFNGWDCNGLVRNWDETVAEMEAEVCRERGGDEMERFCAQYLGFRCFQRFLSG

A0A6J1KJ48 BAG family molecular chaperone regulator 5, mitochondrial

9.9e-88

Show/hide

Query:  MNTTSFYYTTAT-TSFSHSFHNDHSTPPNSTSILIQPSPLLQSSSPAASKIQAAYRSHRIRNLFKTIAAVDREADQIQTLIQRQETVDAVRSNELEKLRM
        MN+TSFYY TAT TSFS+S +N HSTPPNST +L+QPSP     S AA+KIQAAYRSHRIR+L+KTIAA+DREADQIQ LIQRQETVDAVRSN+ EKLRM
Subjt:  MNTTSFYYTTAT-TSFSHSFHNDHSTPPNSTSILIQPSPLLQSSSPAASKIQAAYRSHRIRNLFKTIAAVDREADQIQTLIQRQETVDAVRSNELEKLRM

Query:  NEALMSLLLRLDSVPGIDPAVREARRKVSRRIVGLQEILDAVSEAKVDFNGWDCNGLVRNWDETVAEMEAEVCRERGGDEMERFCAQYLGFRCFQRFLSG
        NEALMS+LLRLDSVPGIDPAVREARRKVSRRIVGLQEILDAVSEAKVDFNGWDC+G VRNWDET+AEMEAEVCRERGGDEMERFCAQ+LGFRCFQRFLSG
Subjt:  NEALMSLLLRLDSVPGIDPAVREARRKVSRRIVGLQEILDAVSEAKVDFNGWDCNGLVRNWDETVAEMEAEVCRERGGDEMERFCAQYLGFRCFQRFLSG

SwissProt top hits

e value

%identity

Alignment

O65373 BAG family molecular chaperone regulator 5, mitochondrial

1.9e-56

56.19

Show/hide

Query:  FYYTTATTSFSHSFHNDHSTPPNSTSILIQ-PSPLLQ-----SSSPAASKIQAAYRSHRIRNLFKTIAAVDREADQIQTLIQRQETVDAVRSNELEKLRM
        F  +T TT+  H+F+NDH+TPP +  I I+ P P  +     +++ AA++IQ+ YRS+RIRNL+K I++++REA+++Q++IQRQETVDA+RS+E E+LRM
Subjt:  FYYTTATTSFSHSFHNDHSTPPNSTSILIQ-PSPLLQ-----SSSPAASKIQAAYRSHRIRNLFKTIAAVDREADQIQTLIQRQETVDAVRSNELEKLRM

Query:  NEALMSLLLRLDSVPGIDPAVREARRKVSRRIVGLQEILDAVSEAKVDFNGWDCNGL------------VRNWDETVAEMEAEVCRERGGDEMERFCAQY
        NE LM+LLL+LDSVPG+DP +REARRKVSR+IVG+QEILD++SE K +   W+ N L               W+E V   E E+CRERGG+EMERFCAQY
Subjt:  NEALMSLLLRLDSVPGIDPAVREARRKVSRRIVGLQEILDAVSEAKVDFNGWDCNGL------------VRNWDETVAEMEAEVCRERGGDEMERFCAQY

Query:  LGFRCFQRFL
        LGFRCFQRFL
Subjt:  LGFRCFQRFL

O82345 BAG family molecular chaperone regulator 6

7.7e-05

28.7

Show/hide

Query:  QPSPLLQSSSPAASKIQAAYRSHRIR-----NLFKTIAAVDREADQIQTLIQRQETVDAVRSNELEKLRMNEALMSLLLRLDSVPGIDPAVREARRKVSR
        QP+    +   AA  IQ+ YR + +R        K IA V  +   ++  I+  E        E E +   E +M+LLL+LD+V G+ P++RE R+ ++ 
Subjt:  QPSPLLQSSSPAASKIQAAYRSHRIR-----NLFKTIAAVDREADQIQTLIQRQETVDAVRSNELEKLRMNEALMSLLLRLDSVPGIDPAVREARRKVSR

Query:  RIVGLQEILDAVSEA
         +  +Q+ LD++  +
Subjt:  RIVGLQEILDAVSEA

Arabidopsis top hits

e value

%identity

Alignment

AT1G12060.1 BCL-2-associated athanogene 5

1.4e-57

56.19

Show/hide

Query:  FYYTTATTSFSHSFHNDHSTPPNSTSILIQ-PSPLLQ-----SSSPAASKIQAAYRSHRIRNLFKTIAAVDREADQIQTLIQRQETVDAVRSNELEKLRM
        F  +T TT+  H+F+NDH+TPP +  I I+ P P  +     +++ AA++IQ+ YRS+RIRNL+K I++++REA+++Q++IQRQETVDA+RS+E E+LRM
Subjt:  FYYTTATTSFSHSFHNDHSTPPNSTSILIQ-PSPLLQ-----SSSPAASKIQAAYRSHRIRNLFKTIAAVDREADQIQTLIQRQETVDAVRSNELEKLRM

Query:  NEALMSLLLRLDSVPGIDPAVREARRKVSRRIVGLQEILDAVSEAKVDFNGWDCNGL------------VRNWDETVAEMEAEVCRERGGDEMERFCAQY
        NE LM+LLL+LDSVPG+DP +REARRKVSR+IVG+QEILD++SE K +   W+ N L               W+E V   E E+CRERGG+EMERFCAQY
Subjt:  NEALMSLLLRLDSVPGIDPAVREARRKVSRRIVGLQEILDAVSEAKVDFNGWDCNGL------------VRNWDETVAEMEAEVCRERGGDEMERFCAQY

Query:  LGFRCFQRFL
        LGFRCFQRFL
Subjt:  LGFRCFQRFL

AT2G46240.1 BCL-2-associated athanogene 6

5.5e-06

28.7

Show/hide

Query:  QPSPLLQSSSPAASKIQAAYRSHRIR-----NLFKTIAAVDREADQIQTLIQRQETVDAVRSNELEKLRMNEALMSLLLRLDSVPGIDPAVREARRKVSR
        QP+    +   AA  IQ+ YR + +R        K IA V  +   ++  I+  E        E E +   E +M+LLL+LD+V G+ P++RE R+ ++ 
Subjt:  QPSPLLQSSSPAASKIQAAYRSHRIR-----NLFKTIAAVDREADQIQTLIQRQETVDAVRSNELEKLRMNEALMSLLLRLDSVPGIDPAVREARRKVSR

Query:  RIVGLQEILDAVSEA
         +  +Q+ LD++  +
Subjt:  RIVGLQEILDAVSEA

Sequences

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CDS sequence

Show/hide CDS sequence

ATGAATACCACATCCTTCTACTACACCACCGCCACCACCTCTTTCTCCCACTCTTTTCACAATGACCATTCTACCCCTCCCAACTCCACATCAATTCTCATCCAA
CCTTCTCCTCTCCTCCAATCCTCCTCCCCCGCCGCCTCCAAGATCCAAGCCGCCTACCGATCTCACCGGATCCGCAATCTCTTCAAAACGATCGCAGCCGTCGAC
AGAGAAGCTGATCAGATCCAGACTCTAATCCAGCGCCAGGAGACGGTCGACGCCGTTAGGAGCAACGAACTCGAGAAGCTGAGGATGAACGAGGCCTTGATGAGT
CTTCTTCTGAGGCTGGACTCGGTGCCAGGGATTGATCCGGCGGTGAGGGAAGCGAGGAGGAAGGTGAGCCGTCGGATCGTCGGCCTGCAGGAGATCTTGGATGCG
GTGTCGGAGGCGAAGGTGGACTTCAACGGATGGGATTGCAACGGACTTGTGAGGAATTGGGACGAGACGGTGGCGGAAATGGAGGCGGAGGTTTGCCGGGAGAGA
GGCGGCGATGAAATGGAGAGGTTCTGCGCTCAGTACTTAGGGTTCCGTTGCTTCCAGAGGTTTCTCAGTGGGTTCTGA

mRNA sequence

Show/hide mRNA sequence

CAATATTCCACTTCCACACTTCTTCTCCCCCGCCCTTCACCCTCCATCGCCTTCCTCCATGAATACCACATCCTTCTACTACACCACCGCCACCACCTCTTTCTC
CCACTCTTTTCACAATGACCATTCTACCCCTCCCAACTCCACATCAATTCTCATCCAACCTTCTCCTCTCCTCCAATCCTCCTCCCCCGCCGCCTCCAAGATCCA
AGCCGCCTACCGATCTCACCGGATCCGCAATCTCTTCAAAACGATCGCAGCCGTCGACAGAGAAGCTGATCAGATCCAGACTCTAATCCAGCGCCAGGAGACGGT
CGACGCCGTTAGGAGCAACGAACTCGAGAAGCTGAGGATGAACGAGGCCTTGATGAGTCTTCTTCTGAGGCTGGACTCGGTGCCAGGGATTGATCCGGCGGTGAG
GGAAGCGAGGAGGAAGGTGAGCCGTCGGATCGTCGGCCTGCAGGAGATCTTGGATGCGGTGTCGGAGGCGAAGGTGGACTTCAACGGATGGGATTGCAACGGACT
TGTGAGGAATTGGGACGAGACGGTGGCGGAAATGGAGGCGGAGGTTTGCCGGGAGAGAGGCGGCGATGAAATGGAGAGGTTCTGCGCTCAGTACTTAGGGTTCCG
TTGCTTCCAGAGGTTTCTCAGTGGGTTCTGATCTGCTGTGGTGTTGCGTATAGTTTGTTTTGAACGTGTTTCATTAGATTTAGACACGTGCTTTATTTGTATTAT
TATTATATATTTTGGTCAGTTAAGGATTTATAAAATGATGTATCATAAAATTACAAAGGAGAGGAAGGAAATTAAATTAGTAAGATATAATCTAGTCGAACAATT
GTATTGAATGTGTTAACAAATATTTTAGTGGTTACCTTATAGAGCTTATTGCCTTCGGAATTAGAAAGGAGTGTAAGTTATGCATTTTG

Protein sequence

Show/hide protein sequence

MNTTSFYYTTATTSFSHSFHNDHSTPPNSTSILIQPSPLLQSSSPAASKIQAAYRSHRIRNLFKTIAAVDREADQIQTLIQRQETVDAVRSNELEKLRMNEALMS
LLLRLDSVPGIDPAVREARRKVSRRIVGLQEILDAVSEAKVDFNGWDCNGLVRNWDETVAEMEAEVCRERGGDEMERFCAQYLGFRCFQRFLSGF

MELO3C021680 (gene) of Melon (DHL92) v4 genome