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MS004504 (gene) of Bitter gourd (TR) v1 genome

Gene IDMS004504
OrganismMomordica charantia cv. TR (Bitter gourd (TR) v1)
DescriptionGamma-secretase subunit PEN-2
Genome locationscaffold1189:175023..182151
RNA-Seq ExpressionMS004504
SyntenyMS004504
Gene Ontology termsGO:0006508 - proteolysis (biological process)
GO:0007219 - Notch signaling pathway (biological process)
GO:0005798 - Golgi-associated vesicle (cellular component)
GO:0016021 - integral component of membrane (cellular component)
GO:0070765 - gamma-secretase complex (cellular component)
GO:0008233 - peptidase activity (molecular function)
InterPro domainsIPR019379 - Gamma-secretase aspartyl protease complex, presenilin enhancer-2 subunit


Homology Show/hide homology
GenBank top hitse value%identityAlignment
KAG6605326.1 putative gamma-secretase subunit PEN-2, partial [Cucurbita argyrosperma subsp. sororia]4.8e-6188.15Show/hide
Query:  MERSQNPNTNP--------NPVSSPIAALWPTIDASLGLSEEESVSYARGFYKFGFALLPFLWAVNCFYFWPVLRDSHSFPRIRPYIVGSAIGFAVFMAI
        ME SQNPNTNP        NPVSS IAALWPTIDASLGLSEEESVSYAR FYKFGFALLPFLWAVNCFYFWPVLRDSHSFPRIRPYIVGSAIGFA+FMAI
Subjt:  MERSQNPNTNP--------NPVSSPIAALWPTIDASLGLSEEESVSYARGFYKFGFALLPFLWAVNCFYFWPVLRDSHSFPRIRPYIVGSAIGFAVFMAI

Query:  LSSWALTFAIGGERLFGPVWDKLVMYNVADKLGLT
        +SSWALTF+IGGERLFGPVW+KLVMYN+ADKLGLT
Subjt:  LSSWALTFAIGGERLFGPVWDKLVMYNVADKLGLT

XP_022156680.1 probable gamma-secretase subunit PEN-2 [Momordica charantia]4.3e-70100Show/hide
Query:  MERSQNPNTNPNPVSSPIAALWPTIDASLGLSEEESVSYARGFYKFGFALLPFLWAVNCFYFWPVLRDSHSFPRIRPYIVGSAIGFAVFMAILSSWALTF
        MERSQNPNTNPNPVSSPIAALWPTIDASLGLSEEESVSYARGFYKFGFALLPFLWAVNCFYFWPVLRDSHSFPRIRPYIVGSAIGFAVFMAILSSWALTF
Subjt:  MERSQNPNTNPNPVSSPIAALWPTIDASLGLSEEESVSYARGFYKFGFALLPFLWAVNCFYFWPVLRDSHSFPRIRPYIVGSAIGFAVFMAILSSWALTF

Query:  AIGGERLFGPVWDKLVMYNVADKLGLTGWN
        AIGGERLFGPVWDKLVMYNVADKLGLTGWN
Subjt:  AIGGERLFGPVWDKLVMYNVADKLGLTGWN

XP_022946973.1 probable gamma-secretase subunit PEN-2 [Cucurbita moschata]3.9e-6387.68Show/hide
Query:  MERSQNPNTNP--------NPVSSPIAALWPTIDASLGLSEEESVSYARGFYKFGFALLPFLWAVNCFYFWPVLRDSHSFPRIRPYIVGSAIGFAVFMAI
        ME SQNPNTNP        NPVSS IAALWPTIDASLGLSEEESVSYAR FYKFGFALLPFLWAVNCFYFWPVLRDSHSFPRIRPYIVGSAIGFA+FMAI
Subjt:  MERSQNPNTNP--------NPVSSPIAALWPTIDASLGLSEEESVSYARGFYKFGFALLPFLWAVNCFYFWPVLRDSHSFPRIRPYIVGSAIGFAVFMAI

Query:  LSSWALTFAIGGERLFGPVWDKLVMYNVADKLGLTGWN
        +SSWALTF+IGGERLFGPVW+KLVMYN+ADKLGLTGW+
Subjt:  LSSWALTFAIGGERLFGPVWDKLVMYNVADKLGLTGWN

XP_023007265.1 probable gamma-secretase subunit PEN-2 [Cucurbita maxima]2.1e-6186.96Show/hide
Query:  MERSQNPNTNP--------NPVSSPIAALWPTIDASLGLSEEESVSYARGFYKFGFALLPFLWAVNCFYFWPVLRDSHSFPRIRPYIVGSAIGFAVFMAI
        ME SQNPNT P        NPVSS IAALWPTIDASLGLS EESVSYAR FYKFGFALLPFLWAVNCFYFWPVLRDSHSFPRIRPYIVGSAIGFAVFMAI
Subjt:  MERSQNPNTNP--------NPVSSPIAALWPTIDASLGLSEEESVSYARGFYKFGFALLPFLWAVNCFYFWPVLRDSHSFPRIRPYIVGSAIGFAVFMAI

Query:  LSSWALTFAIGGERLFGPVWDKLVMYNVADKLGLTGWN
        +SSWALTF+IGGERLFGPVW+KLVMYN+ADKLGLTGW+
Subjt:  LSSWALTFAIGGERLFGPVWDKLVMYNVADKLGLTGWN

XP_023532347.1 probable gamma-secretase subunit PEN-2 [Cucurbita pepo subsp. pepo]5.6e-6286.23Show/hide
Query:  MERSQNPNTNP--------NPVSSPIAALWPTIDASLGLSEEESVSYARGFYKFGFALLPFLWAVNCFYFWPVLRDSHSFPRIRPYIVGSAIGFAVFMAI
        ME S NPNTNP        NPVSS IAALWPTID SLGLSEEESVSYAR FYKFGFALLPFLWAVNCFYFWPVLRDSHSFPRIRPYIVGSAIGFA+FMAI
Subjt:  MERSQNPNTNP--------NPVSSPIAALWPTIDASLGLSEEESVSYARGFYKFGFALLPFLWAVNCFYFWPVLRDSHSFPRIRPYIVGSAIGFAVFMAI

Query:  LSSWALTFAIGGERLFGPVWDKLVMYNVADKLGLTGWN
        +SSWALTF+IGGERLFGPVW+KLVMYN+ADKLGLTGW+
Subjt:  LSSWALTFAIGGERLFGPVWDKLVMYNVADKLGLTGWN

TrEMBL top hitse value%identityAlignment
A0A6J1DR09 probable gamma-secretase subunit PEN-22.1e-70100Show/hide
Query:  MERSQNPNTNPNPVSSPIAALWPTIDASLGLSEEESVSYARGFYKFGFALLPFLWAVNCFYFWPVLRDSHSFPRIRPYIVGSAIGFAVFMAILSSWALTF
        MERSQNPNTNPNPVSSPIAALWPTIDASLGLSEEESVSYARGFYKFGFALLPFLWAVNCFYFWPVLRDSHSFPRIRPYIVGSAIGFAVFMAILSSWALTF
Subjt:  MERSQNPNTNPNPVSSPIAALWPTIDASLGLSEEESVSYARGFYKFGFALLPFLWAVNCFYFWPVLRDSHSFPRIRPYIVGSAIGFAVFMAILSSWALTF

Query:  AIGGERLFGPVWDKLVMYNVADKLGLTGWN
        AIGGERLFGPVWDKLVMYNVADKLGLTGWN
Subjt:  AIGGERLFGPVWDKLVMYNVADKLGLTGWN

A0A6J1F097 probable gamma-secretase subunit PEN-25.1e-6186.96Show/hide
Query:  MERSQNPNTNPNP--------VSSPIAALWPTIDASLGLSEEESVSYARGFYKFGFALLPFLWAVNCFYFWPVLRDSHSFPRIRPYIVGSAIGFAVFMAI
        ME SQN N+NPNP        VSSPIA LWPTID SLGLSEEESVSYAR FYKFGFALLPFLWAVNCFYFWPVLR SHSFPRIRPYIVGSAIGFAVFMAI
Subjt:  MERSQNPNTNPNP--------VSSPIAALWPTIDASLGLSEEESVSYARGFYKFGFALLPFLWAVNCFYFWPVLRDSHSFPRIRPYIVGSAIGFAVFMAI

Query:  LSSWALTFAIGGERLFGPVWDKLVMYNVADKLGLTGWN
        +SSWALTFAIGGERLFGPVWDKLVMYN+ADKLGLTGW+
Subjt:  LSSWALTFAIGGERLFGPVWDKLVMYNVADKLGLTGWN

A0A6J1G5B2 probable gamma-secretase subunit PEN-21.9e-6387.68Show/hide
Query:  MERSQNPNTNP--------NPVSSPIAALWPTIDASLGLSEEESVSYARGFYKFGFALLPFLWAVNCFYFWPVLRDSHSFPRIRPYIVGSAIGFAVFMAI
        ME SQNPNTNP        NPVSS IAALWPTIDASLGLSEEESVSYAR FYKFGFALLPFLWAVNCFYFWPVLRDSHSFPRIRPYIVGSAIGFA+FMAI
Subjt:  MERSQNPNTNP--------NPVSSPIAALWPTIDASLGLSEEESVSYARGFYKFGFALLPFLWAVNCFYFWPVLRDSHSFPRIRPYIVGSAIGFAVFMAI

Query:  LSSWALTFAIGGERLFGPVWDKLVMYNVADKLGLTGWN
        +SSWALTF+IGGERLFGPVW+KLVMYN+ADKLGLTGW+
Subjt:  LSSWALTFAIGGERLFGPVWDKLVMYNVADKLGLTGWN

A0A6J1I943 probable gamma-secretase subunit PEN-26.3e-5985.51Show/hide
Query:  MERSQNPNTNPNP--------VSSPIAALWPTIDASLGLSEEESVSYARGFYKFGFALLPFLWAVNCFYFWPVLRDSHSFPRIRPYIVGSAIGFAVFMAI
        ME SQN N+N NP        VSSPIA LWPTID SLGLSEEESVSYAR FYKFGFALLPFLWAVNCFYFWPVLR S SFPRIRPYIVGSAIGFAVFMAI
Subjt:  MERSQNPNTNPNP--------VSSPIAALWPTIDASLGLSEEESVSYARGFYKFGFALLPFLWAVNCFYFWPVLRDSHSFPRIRPYIVGSAIGFAVFMAI

Query:  LSSWALTFAIGGERLFGPVWDKLVMYNVADKLGLTGWN
        +SSWALTFAIGGERLFGPVWDKLVMYN+ADKLGLTGW+
Subjt:  LSSWALTFAIGGERLFGPVWDKLVMYNVADKLGLTGWN

A0A6J1L2H7 probable gamma-secretase subunit PEN-21.0e-6186.96Show/hide
Query:  MERSQNPNTNP--------NPVSSPIAALWPTIDASLGLSEEESVSYARGFYKFGFALLPFLWAVNCFYFWPVLRDSHSFPRIRPYIVGSAIGFAVFMAI
        ME SQNPNT P        NPVSS IAALWPTIDASLGLS EESVSYAR FYKFGFALLPFLWAVNCFYFWPVLRDSHSFPRIRPYIVGSAIGFAVFMAI
Subjt:  MERSQNPNTNP--------NPVSSPIAALWPTIDASLGLSEEESVSYARGFYKFGFALLPFLWAVNCFYFWPVLRDSHSFPRIRPYIVGSAIGFAVFMAI

Query:  LSSWALTFAIGGERLFGPVWDKLVMYNVADKLGLTGWN
        +SSWALTF+IGGERLFGPVW+KLVMYN+ADKLGLTGW+
Subjt:  LSSWALTFAIGGERLFGPVWDKLVMYNVADKLGLTGWN

SwissProt top hitse value%identityAlignment
Q5G235 Gamma-secretase subunit PEN-28.3e-0835.11Show/hide
Query:  LSEEESVSYARGFYKFGFALLPFLWAVNCFYFWPVLRDSHSFP------RIRPYIVGSAIGFAVFMAILSSWALTFAIGGERLFGPVWDKLVMY
        +S EE ++  R +Y  GFA LPFLW VN F+F+   R++   P      +I+ Y+  SA+GF +++ +LS+W   F     +++ P W  L  Y
Subjt:  LSEEESVSYARGFYKFGFALLPFLWAVNCFYFWPVLRDSHSFP------RIRPYIVGSAIGFAVFMAILSSWALTFAIGGERLFGPVWDKLVMY

Q6QI68 Gamma-secretase subunit PEN-24.1e-0732.97Show/hide
Query:  LSEEESVSYARGFYKFGFALLPFLWAVNCFYFWPVLRDSHSF---PRIRPYIVGSAIGFAVFMAILSSWALTFAIGGERLFGPVWDKLVMY
        +S EE ++  R +Y  GFA LPFLW VN F+F+     + ++    +I+ Y+  SA+GF  ++ +L++W   F     +++ P W  L  Y
Subjt:  LSEEESVSYARGFYKFGFALLPFLWAVNCFYFWPVLRDSHSF---PRIRPYIVGSAIGFAVFMAILSSWALTFAIGGERLFGPVWDKLVMY

Q9CQR7 Gamma-secretase subunit PEN-22.4e-0735.11Show/hide
Query:  LSEEESVSYARGFYKFGFALLPFLWAVNCFYFWPVLRDSHSFP------RIRPYIVGSAIGFAVFMAILSSWALTFAIGGERLFGPVWDKLVMY
        +S EE ++  R +Y  GFA LPFLW VN F+F+   R++   P      +I+ Y+  SA+GF  ++ IL++W   F     +++ P W  L  Y
Subjt:  LSEEESVSYARGFYKFGFALLPFLWAVNCFYFWPVLRDSHSFP------RIRPYIVGSAIGFAVFMAILSSWALTFAIGGERLFGPVWDKLVMY

Q9FY84 Probable gamma-secretase subunit PEN-28.7e-5072.66Show/hide
Query:  RSQNPNTNPNPVSSPI--AALWPTIDASLGLSEEESVSYARGFYKFGFALLPFLWAVNCFYFWPVLRDSHSFPRIRPYIVGSAIGFAVFMAILSSWALTF
        R+ NPN NPNP+S+ I  A +WPTID  LGL+EE SV YAR FYKFGFALLP+LW VNCFYFWPVLR S +FP+IR Y+V SAIGF+VF A+LS+WALTF
Subjt:  RSQNPNTNPNPVSSPI--AALWPTIDASLGLSEEESVSYARGFYKFGFALLPFLWAVNCFYFWPVLRDSHSFPRIRPYIVGSAIGFAVFMAILSSWALTF

Query:  AIGGERLFGPVWDKLVMYNVADKLGLTG
        +IGGE+LFGP++DKLVMYNVAD+LGL+G
Subjt:  AIGGERLFGPVWDKLVMYNVADKLGLTG

Q9NZ42 Gamma-secretase subunit PEN-21.1e-0735.11Show/hide
Query:  LSEEESVSYARGFYKFGFALLPFLWAVNCFYFWPVLRDSHSFP------RIRPYIVGSAIGFAVFMAILSSWALTFAIGGERLFGPVWDKLVMY
        +S EE ++  R +Y  GFA LPFLW VN F+F+   R++   P      +I+ Y+  SA+GF  ++ +L+SW   F     +++ P W  L  Y
Subjt:  LSEEESVSYARGFYKFGFALLPFLWAVNCFYFWPVLRDSHSFP------RIRPYIVGSAIGFAVFMAILSSWALTFAIGGERLFGPVWDKLVMY

Arabidopsis top hitse value%identityAlignment
AT5G09310.1 CONTAINS InterPro DOMAIN/s: Gamma-secretase aspartyl protease complex, presenilin enhancer-2 subunit (InterPro:IPR019379); Has 168 Blast hits to 168 proteins in 71 species: Archae - 0; Bacteria - 0; Metazoa - 126; Fungi - 0; Plants - 36; Viruses - 0; Other Eukaryotes - 6 (source: NCBI BLink).6.2e-5172.66Show/hide
Query:  RSQNPNTNPNPVSSPI--AALWPTIDASLGLSEEESVSYARGFYKFGFALLPFLWAVNCFYFWPVLRDSHSFPRIRPYIVGSAIGFAVFMAILSSWALTF
        R+ NPN NPNP+S+ I  A +WPTID  LGL+EE SV YAR FYKFGFALLP+LW VNCFYFWPVLR S +FP+IR Y+V SAIGF+VF A+LS+WALTF
Subjt:  RSQNPNTNPNPVSSPI--AALWPTIDASLGLSEEESVSYARGFYKFGFALLPFLWAVNCFYFWPVLRDSHSFPRIRPYIVGSAIGFAVFMAILSSWALTF

Query:  AIGGERLFGPVWDKLVMYNVADKLGLTG
        +IGGE+LFGP++DKLVMYNVAD+LGL+G
Subjt:  AIGGERLFGPVWDKLVMYNVADKLGLTG


Sequences Show/hide sequences
CDS sequenceShow/hide CDS sequence
ATGGAGAGATCGCAGAATCCAAACACGAACCCTAATCCTGTATCGTCGCCGATTGCTGCGTTATGGCCGACAATTGATGCGTCACTGGGGTTGTCCGAGGAAGAGTCCGT
GAGCTATGCCCGCGGATTCTACAAATTTGGATTTGCGTTGCTACCATTTCTTTGGGCGGTTAATTGCTTCTACTTCTGGCCTGTTCTCCGCGATTCCCACTCGTTTCCTC
GCATCCGACCCTATATTGTTGGGTCAGCTATTGGGTTTGCTGTTTTCATGGCCATTCTTTCCTCTTGGGCCTTGACATTTGCCATTGGAGGGGAACGTCTCTTTGGACCT
GTTTGGGATAAACTTGTGATGTATAACGTTGCTGACAAATTAGGATTGACAGGTTGGAAC
mRNA sequenceShow/hide mRNA sequence
ATGGAGAGATCGCAGAATCCAAACACGAACCCTAATCCTGTATCGTCGCCGATTGCTGCGTTATGGCCGACAATTGATGCGTCACTGGGGTTGTCCGAGGAAGAGTCCGT
GAGCTATGCCCGCGGATTCTACAAATTTGGATTTGCGTTGCTACCATTTCTTTGGGCGGTTAATTGCTTCTACTTCTGGCCTGTTCTCCGCGATTCCCACTCGTTTCCTC
GCATCCGACCCTATATTGTTGGGTCAGCTATTGGGTTTGCTGTTTTCATGGCCATTCTTTCCTCTTGGGCCTTGACATTTGCCATTGGAGGGGAACGTCTCTTTGGACCT
GTTTGGGATAAACTTGTGATGTATAACGTTGCTGACAAATTAGGATTGACAGGTTGGAAC
Protein sequenceShow/hide protein sequence
MERSQNPNTNPNPVSSPIAALWPTIDASLGLSEEESVSYARGFYKFGFALLPFLWAVNCFYFWPVLRDSHSFPRIRPYIVGSAIGFAVFMAILSSWALTFAIGGERLFGP
VWDKLVMYNVADKLGLTGWN