CuGenDBv2

Gene ID	MS009119
Organism	Momordica charantia cv. TR (Bitter gourd (TR) v1)
Description	Phosphatidylinositol-3,5-bisphosphate 3-phosphatase
Genome location	scaffold220:27691..30904
RNA-Seq Expression	MS009119
Synteny	MS009119
Gene Ontology terms	GO:0006629 - lipid metabolic process (biological process) GO:0035335 - peptidyl-tyrosine dephosphorylation (biological process) GO:0005737 - cytoplasm (cellular component) GO:0004438 - phosphatidylinositol-3-phosphatase activity (molecular function) GO:0004725 - protein tyrosine phosphatase activity (molecular function) GO:0052629 - phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity (molecular function)
InterPro domains	IPR004182 - GRAM domain IPR011993 - PH-like domain superfamily IPR030564 - Myotubularin family

Homology

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GenBank top hits

e value

%identity

Alignment

TYK11740.1 phosphatidylinositol-3-phosphatase myotubularin-1 isoform X1 [Cucumis melo var. makuwa]

2.3e-56

83.8

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Query:  MAAPKPRTSRSKSLRDAPDSEKMDGAYSWDALEWTKIEHVSRSVSRVKLDCLLEAEEVIAEGYGVVLVNTDEAGTLFVTNFRLLFLSEGTMDVIALGTIP
        MAAPKPRT+RS+S RD PD EKMD AYSWDALEWTKIE V+RSVSRV LDCLLEAE+VIAEGYGVVLVNTDEAGTLFVTNFRLLFLSEG+MDVI+LGTIP
Subjt:  MAAPKPRTSRSKSLRDAPDSEKMDGAYSWDALEWTKIEHVSRSVSRVKLDCLLEAEEVIAEGYGVVLVNTDEAGTLFVTNFRLLFLSEGTMDVIALGTIP

Query:  LATIEKFNKIVVKMNSVSRQSEK-SPARRLLQVIGTLCYIIL
        LATI+KFNKIVVK N++SRQSEK SP+RRLLQVIG  C I++
Subjt:  LATIEKFNKIVVKMNSVSRQSEK-SPARRLLQVIGTLCYIIL

XP_011649870.1 phosphatidylinositol-3-phosphatase myotubularin-1 isoform X1 [Cucumis sativus]

2.3e-56

85.31

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Query:  MAAPKPRTSRSKSLRDAPDSEKMDGAYSWDALEWTKIEHVSRSVSRVKLDCLLEAEEVIAEGYGVVLVNTDEAGTLFVTNFRLLFLSEGTMDVIALGTIP
        MAAPKPRT+RS+S RD PD EKMD AYSWDALEWTKIE V+RSVSRV LDCLLEAE+VIAEGYGVVLVNTDEAGTLFVTNFRLLFLSEGTMDVI+LGTIP
Subjt:  MAAPKPRTSRSKSLRDAPDSEKMDGAYSWDALEWTKIEHVSRSVSRVKLDCLLEAEEVIAEGYGVVLVNTDEAGTLFVTNFRLLFLSEGTMDVIALGTIP

Query:  LATIEKFNKIVVKMNSVSRQSEK-SPARRLLQVIGTLCYIILF
        LATI+KFNKIVVK N+VSRQSEK SP+RRLLQVIG    II+F
Subjt:  LATIEKFNKIVVKMNSVSRQSEK-SPARRLLQVIGTLCYIILF

XP_022133856.1 phosphatidylinositol-3-phosphatase myotubularin-1 isoform X1 [Momordica charantia]

1.2e-65

96.48

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Query:  MAAPKPRTSRSKSLRDAPDSEKMDGAYSWDALEWTKIEHVSRSVSRVKLDCLLEAEEVIAEGYGVVLVNTDEAGTLFVTNFRLLFLSEGTMDVIALGTIP
        MAAPKPRTSRSKSLRDAPDSEKMDGAYSWDALEWTKIEHVSRSVSRVKLDCLLEAEEVIAEGYGVVLVNTDEAGTLFVTNFRLLFLSEGTMDVIALGTIP
Subjt:  MAAPKPRTSRSKSLRDAPDSEKMDGAYSWDALEWTKIEHVSRSVSRVKLDCLLEAEEVIAEGYGVVLVNTDEAGTLFVTNFRLLFLSEGTMDVIALGTIP

Query:  LATIEKFNKIVVKMNSVSRQSEKSPARRLLQVIGTLCYIILF
        LATIEKFNKIVVKMNSVSRQSEKSPARRLLQVIG    II+F
Subjt:  LATIEKFNKIVVKMNSVSRQSEKSPARRLLQVIGTLCYIILF

XP_022133859.1 phosphatidylinositol-3-phosphatase myotubularin-1 isoform X4 [Momordica charantia]

1.2e-65

96.48

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Query:  MAAPKPRTSRSKSLRDAPDSEKMDGAYSWDALEWTKIEHVSRSVSRVKLDCLLEAEEVIAEGYGVVLVNTDEAGTLFVTNFRLLFLSEGTMDVIALGTIP
        MAAPKPRTSRSKSLRDAPDSEKMDGAYSWDALEWTKIEHVSRSVSRVKLDCLLEAEEVIAEGYGVVLVNTDEAGTLFVTNFRLLFLSEGTMDVIALGTIP
Subjt:  MAAPKPRTSRSKSLRDAPDSEKMDGAYSWDALEWTKIEHVSRSVSRVKLDCLLEAEEVIAEGYGVVLVNTDEAGTLFVTNFRLLFLSEGTMDVIALGTIP

Query:  LATIEKFNKIVVKMNSVSRQSEKSPARRLLQVIGTLCYIILF
        LATIEKFNKIVVKMNSVSRQSEKSPARRLLQVIG    II+F
Subjt:  LATIEKFNKIVVKMNSVSRQSEKSPARRLLQVIGTLCYIILF

XP_031736655.1 phosphatidylinositol-3-phosphatase myotubularin-1 isoform X2 [Cucumis sativus]

2.3e-56

85.31

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Query:  MAAPKPRTSRSKSLRDAPDSEKMDGAYSWDALEWTKIEHVSRSVSRVKLDCLLEAEEVIAEGYGVVLVNTDEAGTLFVTNFRLLFLSEGTMDVIALGTIP
        MAAPKPRT+RS+S RD PD EKMD AYSWDALEWTKIE V+RSVSRV LDCLLEAE+VIAEGYGVVLVNTDEAGTLFVTNFRLLFLSEGTMDVI+LGTIP
Subjt:  MAAPKPRTSRSKSLRDAPDSEKMDGAYSWDALEWTKIEHVSRSVSRVKLDCLLEAEEVIAEGYGVVLVNTDEAGTLFVTNFRLLFLSEGTMDVIALGTIP

Query:  LATIEKFNKIVVKMNSVSRQSEK-SPARRLLQVIGTLCYIILF
        LATI+KFNKIVVK N+VSRQSEK SP+RRLLQVIG    II+F
Subjt:  LATIEKFNKIVVKMNSVSRQSEK-SPARRLLQVIGTLCYIILF

TrEMBL top hits

e value

%identity

Alignment

A0A0A0LMM6 Myotubularin phosphatase domain-containing protein

1.1e-56

85.31

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Query:  MAAPKPRTSRSKSLRDAPDSEKMDGAYSWDALEWTKIEHVSRSVSRVKLDCLLEAEEVIAEGYGVVLVNTDEAGTLFVTNFRLLFLSEGTMDVIALGTIP
        MAAPKPRT+RS+S RD PD EKMD AYSWDALEWTKIE V+RSVSRV LDCLLEAE+VIAEGYGVVLVNTDEAGTLFVTNFRLLFLSEGTMDVI+LGTIP
Subjt:  MAAPKPRTSRSKSLRDAPDSEKMDGAYSWDALEWTKIEHVSRSVSRVKLDCLLEAEEVIAEGYGVVLVNTDEAGTLFVTNFRLLFLSEGTMDVIALGTIP

Query:  LATIEKFNKIVVKMNSVSRQSEK-SPARRLLQVIGTLCYIILF
        LATI+KFNKIVVK N+VSRQSEK SP+RRLLQVIG    II+F
Subjt:  LATIEKFNKIVVKMNSVSRQSEK-SPARRLLQVIGTLCYIILF

A0A5D3CJZ8 Phosphatidylinositol-3-phosphatase myotubularin-1 isoform X1

1.1e-56

83.8

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Query:  MAAPKPRTSRSKSLRDAPDSEKMDGAYSWDALEWTKIEHVSRSVSRVKLDCLLEAEEVIAEGYGVVLVNTDEAGTLFVTNFRLLFLSEGTMDVIALGTIP
        MAAPKPRT+RS+S RD PD EKMD AYSWDALEWTKIE V+RSVSRV LDCLLEAE+VIAEGYGVVLVNTDEAGTLFVTNFRLLFLSEG+MDVI+LGTIP
Subjt:  MAAPKPRTSRSKSLRDAPDSEKMDGAYSWDALEWTKIEHVSRSVSRVKLDCLLEAEEVIAEGYGVVLVNTDEAGTLFVTNFRLLFLSEGTMDVIALGTIP

Query:  LATIEKFNKIVVKMNSVSRQSEK-SPARRLLQVIGTLCYIIL
        LATI+KFNKIVVK N++SRQSEK SP+RRLLQVIG  C I++
Subjt:  LATIEKFNKIVVKMNSVSRQSEK-SPARRLLQVIGTLCYIIL

A0A6J1BWC3 Phosphatidylinositol-3,5-bisphosphate 3-phosphatase

5.9e-66

96.48

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Query:  MAAPKPRTSRSKSLRDAPDSEKMDGAYSWDALEWTKIEHVSRSVSRVKLDCLLEAEEVIAEGYGVVLVNTDEAGTLFVTNFRLLFLSEGTMDVIALGTIP
        MAAPKPRTSRSKSLRDAPDSEKMDGAYSWDALEWTKIEHVSRSVSRVKLDCLLEAEEVIAEGYGVVLVNTDEAGTLFVTNFRLLFLSEGTMDVIALGTIP
Subjt:  MAAPKPRTSRSKSLRDAPDSEKMDGAYSWDALEWTKIEHVSRSVSRVKLDCLLEAEEVIAEGYGVVLVNTDEAGTLFVTNFRLLFLSEGTMDVIALGTIP

Query:  LATIEKFNKIVVKMNSVSRQSEKSPARRLLQVIGTLCYIILF
        LATIEKFNKIVVKMNSVSRQSEKSPARRLLQVIG    II+F
Subjt:  LATIEKFNKIVVKMNSVSRQSEKSPARRLLQVIGTLCYIILF

A0A6J1BX59 Phosphatidylinositol-3,5-bisphosphate 3-phosphatase

5.9e-66

96.48

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Query:  MAAPKPRTSRSKSLRDAPDSEKMDGAYSWDALEWTKIEHVSRSVSRVKLDCLLEAEEVIAEGYGVVLVNTDEAGTLFVTNFRLLFLSEGTMDVIALGTIP
        MAAPKPRTSRSKSLRDAPDSEKMDGAYSWDALEWTKIEHVSRSVSRVKLDCLLEAEEVIAEGYGVVLVNTDEAGTLFVTNFRLLFLSEGTMDVIALGTIP
Subjt:  MAAPKPRTSRSKSLRDAPDSEKMDGAYSWDALEWTKIEHVSRSVSRVKLDCLLEAEEVIAEGYGVVLVNTDEAGTLFVTNFRLLFLSEGTMDVIALGTIP

Query:  LATIEKFNKIVVKMNSVSRQSEKSPARRLLQVIGTLCYIILF
        LATIEKFNKIVVKMNSVSRQSEKSPARRLLQVIG    II+F
Subjt:  LATIEKFNKIVVKMNSVSRQSEKSPARRLLQVIGTLCYIILF

A0A6J1JVN6 Phosphatidylinositol-3,5-bisphosphate 3-phosphatase

4.2e-56

85.31

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Query:  MAAPKPRTSRSKSLRDAPDSEKMDGAYSWDALEWTKIEHVSRSVSRVKLDCLLEAEEVIAEGYGVVLVNTDEAGTLFVTNFRLLFLSEGTMDVIALGTIP
        MAAPKPRT+RS+S RD PD EKMDGAYSWDALEWTKIE V RSVSRV  DCLL+AE+VIAEGYGVVLVNTDEAGTLFVTNFRLLFLSEGTMDVIALGTIP
Subjt:  MAAPKPRTSRSKSLRDAPDSEKMDGAYSWDALEWTKIEHVSRSVSRVKLDCLLEAEEVIAEGYGVVLVNTDEAGTLFVTNFRLLFLSEGTMDVIALGTIP

Query:  LATIEKFNKIVVKMNSVSRQSEK-SPARRLLQVIGTLCYIILF
        LATI+KFNKIVVK NSVSRQSEK S +RRLLQVIG    II+F
Subjt:  LATIEKFNKIVVKMNSVSRQSEK-SPARRLLQVIGTLCYIILF

SwissProt top hits

e value

%identity

Alignment

F4J3T8 Phosphatidylinositol-3-phosphatase myotubularin-1

2.6e-42

65.03

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Query:  MAAPKPRTSRSKSLRD-APDSEKMDGAYSWDALEWTKIEHVSRSVSRVKLDCLLEAEEVIAEGYGVVLVNTDEAGTLFVTNFRLLFLSEGTMDVIALGTI
        M  P+P + R +SLRD + +SEKMDG  SWD LEWTK++  S S S   L CLLE+E VI EGYGVVL+NTDEAGTL VTNFR+LFLSEGT  VI LGTI
Subjt:  MAAPKPRTSRSKSLRD-APDSEKMDGAYSWDALEWTKIEHVSRSVSRVKLDCLLEAEEVIAEGYGVVLVNTDEAGTLFVTNFRLLFLSEGTMDVIALGTI

Query:  PLATIEKFNKIVVKMNSVSRQSEKSPARRLLQVIGTLCYIILF
        PLATIEKFNK+V+K+ S  RQS+K P RRLLQV G    II++
Subjt:  PLATIEKFNKIVVKMNSVSRQSEKSPARRLLQVIGTLCYIILF

F4JWB3 Phosphatidylinositol-3-phosphatase myotubularin-2

7.0e-32

52.11

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Query:  MAAPKPRTSRSKSLRDAPDSEKMDGAYSWDALEWTKIEHVSRSVSRVKLDCLLEAEEVIAEGYGVVLVNTDEAGTLFVTNFRLLFLSEGTMDVIALGTIP
        M A +P + RS+SLR +  SEKM+G  SWD LEWTK++  S S S   LDCLLE+E +I E  GV+L+NTDEAGTL ++NFR+LFLSEGT  ++ LGTIP
Subjt:  MAAPKPRTSRSKSLRDAPDSEKMDGAYSWDALEWTKIEHVSRSVSRVKLDCLLEAEEVIAEGYGVVLVNTDEAGTLFVTNFRLLFLSEGTMDVIALGTIP

Query:  LATIEKFNKIVVKMNSVSRQSEKSPARRLLQVIGTLCYIILF
           IEKFNK+  K+ S    + ++   RLLQV G    I+++
Subjt:  LATIEKFNKIVVKMNSVSRQSEKSPARRLLQVIGTLCYIILF

Arabidopsis top hits

e value

%identity

Alignment

AT3G10550.1 Myotubularin-like phosphatases II superfamily

1.8e-43

65.03

Show/hide

Query:  MAAPKPRTSRSKSLRD-APDSEKMDGAYSWDALEWTKIEHVSRSVSRVKLDCLLEAEEVIAEGYGVVLVNTDEAGTLFVTNFRLLFLSEGTMDVIALGTI
        M  P+P + R +SLRD + +SEKMDG  SWD LEWTK++  S S S   L CLLE+E VI EGYGVVL+NTDEAGTL VTNFR+LFLSEGT  VI LGTI
Subjt:  MAAPKPRTSRSKSLRD-APDSEKMDGAYSWDALEWTKIEHVSRSVSRVKLDCLLEAEEVIAEGYGVVLVNTDEAGTLFVTNFRLLFLSEGTMDVIALGTI

Query:  PLATIEKFNKIVVKMNSVSRQSEKSPARRLLQVIGTLCYIILF
        PLATIEKFNK+V+K+ S  RQS+K P RRLLQV G    II++
Subjt:  PLATIEKFNKIVVKMNSVSRQSEKSPARRLLQVIGTLCYIILF

AT5G04540.1 Myotubularin-like phosphatases II superfamily

5.0e-33

52.11

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Query:  MAAPKPRTSRSKSLRDAPDSEKMDGAYSWDALEWTKIEHVSRSVSRVKLDCLLEAEEVIAEGYGVVLVNTDEAGTLFVTNFRLLFLSEGTMDVIALGTIP
        M A +P + RS+SLR +  SEKM+G  SWD LEWTK++  S S S   LDCLLE+E +I E  GV+L+NTDEAGTL ++NFR+LFLSEGT  ++ LGTIP
Subjt:  MAAPKPRTSRSKSLRDAPDSEKMDGAYSWDALEWTKIEHVSRSVSRVKLDCLLEAEEVIAEGYGVVLVNTDEAGTLFVTNFRLLFLSEGTMDVIALGTIP

Query:  LATIEKFNKIVVKMNSVSRQSEKSPARRLLQVIGTLCYIILF
           IEKFNK+  K+ S    + ++   RLLQV G    I+++
Subjt:  LATIEKFNKIVVKMNSVSRQSEKSPARRLLQVIGTLCYIILF

Sequences

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CDS sequence

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ATGGCAGCGCCAAAGCCACGCACCAGTCGCTCCAAGTCTCTCAGGGATGCTCCTGATTCGGAGAAGATGGACGGTGCCTATAGCTGGGACGCCCTCGAATGGACCAAGAT
TGAGCACGTTTCGCGGTCTGTTTCGCGTGTGAAATTGGATTGCTTGCTTGAAGCGGAGGAAGTCATTGCTGAGGGCTATGGTGTTGTTCTTGTGAATACCGATGAGGCGG
GTACCTTGTTTGTAACCAATTTTCGTCTTCTATTTCTGAGTGAAGGAACGATGGATGTTATTGCCCTTGGGACTATACCACTGGCCACAATTGAAAAATTCAACAAAATA
GTTGTGAAGATGAATTCTGTCTCTCGCCAATCTGAAAAGTCTCCAGCTCGACGACTTCTTCAGGTCATTGGTACGCTTTGTTATATAATCTTATTTGTTGATGCA

mRNA sequence

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Protein sequence

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MAAPKPRTSRSKSLRDAPDSEKMDGAYSWDALEWTKIEHVSRSVSRVKLDCLLEAEEVIAEGYGVVLVNTDEAGTLFVTNFRLLFLSEGTMDVIALGTIPLATIEKFNKI
VVKMNSVSRQSEKSPARRLLQVIGTLCYIILFVDA

MS009119 (gene) of Bitter gourd (TR) v1 genome