CuGenDBv2

Gene ID	Moc05g02430
Organism	Momordica charantia cv. OHB3-1 (Bitter gourd (OHB3-1) v2)
Description	PMEI domain-containing protein
Genome location	chr5:1613249..1613815
RNA-Seq Expression	Moc05g02430
Synteny	Moc05g02430
Gene Ontology terms	GO:0043086 - negative regulation of catalytic activity (biological process) GO:0004857 - enzyme inhibitor activity (molecular function)
InterPro domains	IPR006501 - Pectinesterase inhibitor domain IPR034088 - Pla a 1-like IPR035513 - Invertase/pectin methylesterase inhibitor domain superfamily

Homology

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GenBank top hits

e value

%identity

Alignment

KAA0049108.1 putative invertase inhibitor [Cucumis melo var. makuwa]

1.7e-35

50.27

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Query:  THRLISLALSFFVVFQFQFEGIAGGANDVVIRTCNIAAARDRNNIHVDLCVKALAAAPGSESANLFELGAISIELAREKASETRVVIESLLQNKKKNKKN
        THR I+LA SF V+  F+       AND+V RTC  +AARD  N+ +D C+++LAAAPGS++A+L+ELGAISI L    A+ T+  IE LL+N+KK   +
Subjt:  THRLISLALSFFVVFQFQFEGIAGGANDVVIRTCNIAAARDRNNIHVDLCVKALAAAPGSESANLFELGAISIELAREKASETRVVIESLLQNKKKNKKN

Query:  KNALR----DCEKLYTDAAAALRVATADYLSGRYGDAKTKLSVVMTAVTSCEDGFKE-HGVVSPLAKRNADAFQLSAVSLSILAMRP
         + +R    DCE+LY+DA   +  A A+Y   RY +   KLS VM AVT+CEDGFKE    VSPL KRN D F+L+A++L IL +RP
Subjt:  KNALR----DCEKLYTDAAAALRVATADYLSGRYGDAKTKLSVVMTAVTSCEDGFKE-HGVVSPLAKRNADAFQLSAVSLSILAMRP

KAG6582515.1 hypothetical protein SDJN03_22517, partial [Cucurbita argyrosperma subsp. sororia]

1.1e-37

53.65

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Query:  THRLISLALSFFVVFQFQFEGIAGGANDVVIRTCNIAAARDRNNIHVDLCVKALAAAPGSESANLFELGAISIELAREKASETRVVIESLLQNKKKNKKN
        THR I+LA S FV         +  ANDVV RTC I+AA+D  N+H+D C+++LAAAP S++A+L+ELGAISIEL    A+ TR  IE LL   KKNKK 
Subjt:  THRLISLALSFFVVFQFQFEGIAGGANDVVIRTCNIAAARDRNNIHVDLCVKALAAAPGSESANLFELGAISIELAREKASETRVVIESLLQNKKKNKKN

Query:  KN---------ALRDCEKLYTDAAAALRVATADYLSGRYGDAKTKLSVVMTAVTSCEDGFKE-HGVVSPLAKRNADAFQLSAVSLSILAMRP
        KN          L DC +LY+D    +R A ADY S RY +   KLS VM A T+CEDGFKE  G VSPL KRN DAF+L+A++L IL MRP
Subjt:  KN---------ALRDCEKLYTDAAAALRVATADYLSGRYGDAKTKLSVVMTAVTSCEDGFKE-HGVVSPLAKRNADAFQLSAVSLSILAMRP

XP_008438273.1 PREDICTED: putative invertase inhibitor [Cucumis melo]

1.7e-35

50.27

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Query:  THRLISLALSFFVVFQFQFEGIAGGANDVVIRTCNIAAARDRNNIHVDLCVKALAAAPGSESANLFELGAISIELAREKASETRVVIESLLQNKKKNKKN
        THR I+LA SF V+  F+       AND+V RTC  +AARD  N+ +D C+++LAAAPGS++A+L+ELGAISI L    A+ T+  IE LL+N+KK   +
Subjt:  THRLISLALSFFVVFQFQFEGIAGGANDVVIRTCNIAAARDRNNIHVDLCVKALAAAPGSESANLFELGAISIELAREKASETRVVIESLLQNKKKNKKN

Query:  KNALR----DCEKLYTDAAAALRVATADYLSGRYGDAKTKLSVVMTAVTSCEDGFKE-HGVVSPLAKRNADAFQLSAVSLSILAMRP
         + +R    DCE+LY+DA   +  A A+Y   RY +   KLS VM AVT+CEDGFKE    VSPL KRN D F+L+A++L IL +RP
Subjt:  KNALR----DCEKLYTDAAAALRVATADYLSGRYGDAKTKLSVVMTAVTSCEDGFKE-HGVVSPLAKRNADAFQLSAVSLSILAMRP

XP_022924291.1 putative invertase inhibitor [Cucurbita moschata]

1.8e-37

52.91

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Query:  THRLISLALSFFVVFQFQFEGIAGGANDVVIRTCNIAAARDRNNIHVDLCVKALAAAPGSESANLFELGAISIELAREKASETRVVIESLLQNKKKNKKN
        THR I+LA S FV         +  ANDVV RTC I+AA+D  N+H+D C+++LAAAP S++A+L+ELGAISIEL    A+ TR  IE LL+ KKK K  
Subjt:  THRLISLALSFFVVFQFQFEGIAGGANDVVIRTCNIAAARDRNNIHVDLCVKALAAAPGSESANLFELGAISIELAREKASETRVVIESLLQNKKKNKKN

Query:  ------KNALRDCEKLYTDAAAALRVATADYLSGRYGDAKTKLSVVMTAVTSCEDGFKE-HGVVSPLAKRNADAFQLSAVSLSILAMRP
              +  L DC +LY+D    +R A ADY S RY +   KLS +M AVT+CEDGFKE  G VSPL KRN DAF+L+A++L IL MRP
Subjt:  ------KNALRDCEKLYTDAAAALRVATADYLSGRYGDAKTKLSVVMTAVTSCEDGFKE-HGVVSPLAKRNADAFQLSAVSLSILAMRP

XP_023528439.1 putative invertase inhibitor [Cucurbita pepo subsp. pepo]

2.8e-38

54.69

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Query:  THRLISLALSFFVVFQFQFEGIAGGANDVVIRTCNIAAARDRNNIHVDLCVKALAAAPGSESANLFELGAISIELAREKASETRVVIESLLQNKKKNKKN
        THR I+LA S FV         +  ANDVV RTC I+AA+D  N+H+D C+++LAAAP S+ A+L+ELGAISIEL    A+ TR  IE LL   KKNKK 
Subjt:  THRLISLALSFFVVFQFQFEGIAGGANDVVIRTCNIAAARDRNNIHVDLCVKALAAAPGSESANLFELGAISIELAREKASETRVVIESLLQNKKKNKKN

Query:  KN---------ALRDCEKLYTDAAAALRVATADYLSGRYGDAKTKLSVVMTAVTSCEDGFKE-HGVVSPLAKRNADAFQLSAVSLSILAMRP
        KN          L DC +LY+D  A +R A ADY S RY +   KLS VM AVT+CEDGFKE  G VSPL KRN DAF+L+A++L IL MRP
Subjt:  KN---------ALRDCEKLYTDAAAALRVATADYLSGRYGDAKTKLSVVMTAVTSCEDGFKE-HGVVSPLAKRNADAFQLSAVSLSILAMRP

TrEMBL top hits

e value

%identity

Alignment

A0A0A0L7T4 PMEI domain-containing protein

3.1e-35

51.09

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Query:  HRLISLALSFFVVFQFQFEGIAGGANDVVIRTCNIAAARDRNNIHVDLCVKALAAAPGSESANLFELGAISIELAREKASETRVVIESLLQNKKKNKKN-
        HR I+LALSFFV+F  +    +  AND + R C ++AA D  N+ +D C+++LAAAPGS++A+L+ELGA+SI+L    A+ TR  IE LL+N+KK+    
Subjt:  HRLISLALSFFVVFQFQFEGIAGGANDVVIRTCNIAAARDRNNIHVDLCVKALAAAPGSESANLFELGAISIELAREKASETRVVIESLLQNKKKNKKN-

Query:  -KNALRDCEKLYTDAAAALRVATADYLSGRYGDAKTKLSVVMTAVTSCEDGFKE-HGVVSPLAKRNADAFQLSAVSLSILAMRP
         +  L DCE+LY DA  A+  A  +Y   RY +   KLS VM AVT+CEDGFKE  G VSPL KRN D F+L+A++LSIL +RP
Subjt:  -KNALRDCEKLYTDAAAALRVATADYLSGRYGDAKTKLSVVMTAVTSCEDGFKE-HGVVSPLAKRNADAFQLSAVSLSILAMRP

A0A1S3AVZ7 putative invertase inhibitor

8.3e-36

50.27

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Query:  THRLISLALSFFVVFQFQFEGIAGGANDVVIRTCNIAAARDRNNIHVDLCVKALAAAPGSESANLFELGAISIELAREKASETRVVIESLLQNKKKNKKN
        THR I+LA SF V+  F+       AND+V RTC  +AARD  N+ +D C+++LAAAPGS++A+L+ELGAISI L    A+ T+  IE LL+N+KK   +
Subjt:  THRLISLALSFFVVFQFQFEGIAGGANDVVIRTCNIAAARDRNNIHVDLCVKALAAAPGSESANLFELGAISIELAREKASETRVVIESLLQNKKKNKKN

Query:  KNALR----DCEKLYTDAAAALRVATADYLSGRYGDAKTKLSVVMTAVTSCEDGFKE-HGVVSPLAKRNADAFQLSAVSLSILAMRP
         + +R    DCE+LY+DA   +  A A+Y   RY +   KLS VM AVT+CEDGFKE    VSPL KRN D F+L+A++L IL +RP
Subjt:  KNALR----DCEKLYTDAAAALRVATADYLSGRYGDAKTKLSVVMTAVTSCEDGFKE-HGVVSPLAKRNADAFQLSAVSLSILAMRP

A0A5A7U1K7 Putative invertase inhibitor

8.3e-36

50.27

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Query:  THRLISLALSFFVVFQFQFEGIAGGANDVVIRTCNIAAARDRNNIHVDLCVKALAAAPGSESANLFELGAISIELAREKASETRVVIESLLQNKKKNKKN
        THR I+LA SF V+  F+       AND+V RTC  +AARD  N+ +D C+++LAAAPGS++A+L+ELGAISI L    A+ T+  IE LL+N+KK   +
Subjt:  THRLISLALSFFVVFQFQFEGIAGGANDVVIRTCNIAAARDRNNIHVDLCVKALAAAPGSESANLFELGAISIELAREKASETRVVIESLLQNKKKNKKN

Query:  KNALR----DCEKLYTDAAAALRVATADYLSGRYGDAKTKLSVVMTAVTSCEDGFKE-HGVVSPLAKRNADAFQLSAVSLSILAMRP
         + +R    DCE+LY+DA   +  A A+Y   RY +   KLS VM AVT+CEDGFKE    VSPL KRN D F+L+A++L IL +RP
Subjt:  KNALR----DCEKLYTDAAAALRVATADYLSGRYGDAKTKLSVVMTAVTSCEDGFKE-HGVVSPLAKRNADAFQLSAVSLSILAMRP

A0A6J1E955 putative invertase inhibitor

8.8e-38

52.91

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Query:  THRLISLALSFFVVFQFQFEGIAGGANDVVIRTCNIAAARDRNNIHVDLCVKALAAAPGSESANLFELGAISIELAREKASETRVVIESLLQNKKKNKKN
        THR I+LA S FV         +  ANDVV RTC I+AA+D  N+H+D C+++LAAAP S++A+L+ELGAISIEL    A+ TR  IE LL+ KKK K  
Subjt:  THRLISLALSFFVVFQFQFEGIAGGANDVVIRTCNIAAARDRNNIHVDLCVKALAAAPGSESANLFELGAISIELAREKASETRVVIESLLQNKKKNKKN

Query:  ------KNALRDCEKLYTDAAAALRVATADYLSGRYGDAKTKLSVVMTAVTSCEDGFKE-HGVVSPLAKRNADAFQLSAVSLSILAMRP
              +  L DC +LY+D    +R A ADY S RY +   KLS +M AVT+CEDGFKE  G VSPL KRN DAF+L+A++L IL MRP
Subjt:  ------KNALRDCEKLYTDAAAALRVATADYLSGRYGDAKTKLSVVMTAVTSCEDGFKE-HGVVSPLAKRNADAFQLSAVSLSILAMRP

A0A6J1ITK8 putative invertase inhibitor

4.1e-35

56.89

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Query:  ANDVVIRTCNIAAARDRNNIHVDLCVKALAAAPGSESANLFELGAISIELAREKASETRVVIESLLQNKKKNKKNKN---------ALRDCEKLYTDAAA
        ANDVV R C I AA+D  N+H+D C+++LAAAP S+ A+L+ELGAISIEL    A+ TR  IE LL   KKNKK KN          L DC +LY+D  A
Subjt:  ANDVVIRTCNIAAARDRNNIHVDLCVKALAAAPGSESANLFELGAISIELAREKASETRVVIESLLQNKKKNKKNKN---------ALRDCEKLYTDAAA

Query:  ALRVATADYLSGRYGDAKTKLSVVMTAVTSCEDGFKE-HGVVSPLAKRNADAFQLSAVSLSILAMRP
         +R A ADY S RY +   KLS VM AVT+CEDGFKE  G VSPL KRN DAF+L+A++L IL MRP
Subjt:  ALRVATADYLSGRYGDAKTKLSVVMTAVTSCEDGFKE-HGVVSPLAKRNADAFQLSAVSLSILAMRP

SwissProt top hits

e value

%identity

Alignment

A9YUH4 Putative invertase inhibitor

8.0e-20

41.72

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Query:  DVVIRTCNIAAARDRNNIHVDLCVKALAAAPGSESANLFELGAISIELAREKASETRVVIESLLQNKKKNKKNKNALRDCEKLYTDAAAALRVATADYLS
        D+V  TC   A R   N++ D CVK+L A P S SA+L  LG IS  LA ++ S+ +  I  +L++ K +   K  L DC  LY DA ++++ A AD+ S
Subjt:  DVVIRTCNIAAARDRNNIHVDLCVKALAAAPGSESANLFELGAISIELAREKASETRVVIESLLQNKKKNKKNKNALRDCEKLYTDAAAALRVATADYLS

Query:  GRYGDAKTKLSVVMTAVTSCEDGFKE-HGVVSPLAKRNADAFQLSAVSLSI
          Y  A  K+S  +    +CEDGFKE  G+ SP+ K N D  QL+A+SL+I
Subjt:  GRYGDAKTKLSVVMTAVTSCEDGFKE-HGVVSPLAKRNADAFQLSAVSLSI

Q8GT41 Putative invertase inhibitor

1.0e-19

41.72

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Query:  DVVIRTCNIAAARDRNNIHVDLCVKALAAAPGSESANLFELGAISIELAREKASETRVVIESLLQNKKKNKKNKNALRDCEKLYTDAAAALRVATADYLS
        D+V  TC   A R   N++ D CVK+L A P S +A+L  LG IS  LA +  S+ +  I  +L++ K +   K  L DC  LY DA ++++ A AD+ S
Subjt:  DVVIRTCNIAAARDRNNIHVDLCVKALAAAPGSESANLFELGAISIELAREKASETRVVIESLLQNKKKNKKNKNALRDCEKLYTDAAAALRVATADYLS

Query:  GRYGDAKTKLSVVMTAVTSCEDGFKE-HGVVSPLAKRNADAFQLSAVSLSI
          Y  A  K+S  +    +CEDGFKE  G+VSP+ K N D  QL+A+SL+I
Subjt:  GRYGDAKTKLSVVMTAVTSCEDGFKE-HGVVSPLAKRNADAFQLSAVSLSI

Arabidopsis top hits

e value

%identity

Alignment

AT3G36659.1 Plant invertase/pectin methylesterase inhibitor superfamily protein

9.7e-05

41.07

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Query:  DCEKLYTDAAAALRVATADYLSGRYGDAKTKLSVVMTAVTSCEDGFKEHGVVSPLA
        DC++LY DA   L  A     S       T LS  MT  ++C DGF+E G  +PLA
Subjt:  DCEKLYTDAAAALRVATADYLSGRYGDAKTKLSVVMTAVTSCEDGFKEHGVVSPLA

AT5G46940.1 Plant invertase/pectin methylesterase inhibitor superfamily protein

1.8e-14

32.95

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Query:  LSFFVVFQFQFEGIAGGANDVVIRTCNIAAARDRNNIHVDLCVKALAAAPGSESA-NLFELGAISIELAREKASETRVVIESLLQNKKKNKKNKNALRDC
        L + V F     G+A G    +IR     A         +LCV +L   P +++A +L  L   S + A  KA+  +  ++ +++ KK NK     LRDC
Subjt:  LSFFVVFQFQFEGIAGGANDVVIRTCNIAAARDRNNIHVDLCVKALAAAPGSESA-NLFELGAISIELAREKASETRVVIESLLQNKKKNKKNKNALRDC

Query:  EKLYTDAAAALRVATADYLSGRYGDAKTKLSVVMTAVTSCEDGFKEHGVVSPLAKRNADAFQLSAVSLSILAM
         +LYTDA  +L  A A   S  Y   KT LS  M   ++CE GFKE    SP+ K N + +Q+  + L+   M
Subjt:  EKLYTDAAAALRVATADYLSGRYGDAKTKLSVVMTAVTSCEDGFKEHGVVSPLAKRNADAFQLSAVSLSILAM

Sequences

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CDS sequence

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ATGAGTGCTCCAACGCACCGTTTAATCTCGCTGGCGCTGTCATTCTTCGTGGTGTTCCAGTTCCAGTTCGAAGGCATCGCCGGCGGCGCAAACGACGTCGTTATCCGAAC
CTGCAACATCGCCGCCGCGAGAGACCGCAACAACATCCACGTGGACCTGTGCGTGAAAGCTCTGGCGGCGGCGCCGGGGAGCGAGTCGGCGAACCTGTTCGAACTCGGGG
CGATCTCGATCGAGTTGGCGAGGGAGAAGGCGAGCGAGACGCGGGTGGTGATCGAGAGCCTGCTGCAGAACAAGAAGAAGAACAAGAAGAACAAGAATGCGCTCAGAGAT
TGCGAGAAGCTGTACACGGACGCCGCCGCGGCGCTGCGGGTTGCGACGGCGGATTACTTGTCCGGCCGCTACGGAGATGCGAAGACGAAATTGAGCGTCGTTATGACGGC
GGTTACATCTTGTGAAGACGGATTCAAGGAACACGGCGTCGTTTCGCCATTGGCCAAGCGCAACGCCGATGCGTTTCAGTTATCCGCCGTTTCCCTCTCTATCCTCGCTA
TGCGTCCACAACCTTGA

mRNA sequence

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Protein sequence

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MSAPTHRLISLALSFFVVFQFQFEGIAGGANDVVIRTCNIAAARDRNNIHVDLCVKALAAAPGSESANLFELGAISIELAREKASETRVVIESLLQNKKKNKKNKNALRD
CEKLYTDAAAALRVATADYLSGRYGDAKTKLSVVMTAVTSCEDGFKEHGVVSPLAKRNADAFQLSAVSLSILAMRPQP

Moc05g02430 (gene) of Bitter gourd (OHB3-1) v2 genome