CuGenDBv2

Gene ID	PI0022127
Organism	Cucumis metuliferus PI 482460 (Melon (PI 482460) v1)
Description	DNA topoisomerase
Genome location	chr06:6004947..6020755
RNA-Seq Expression	PI0022127
Synteny	PI0022127
Gene Ontology terms	GO:0006265 - DNA topological change (biological process) GO:0005634 - nucleus (cellular component) GO:0003677 - DNA binding (molecular function) GO:0003917 - DNA topoisomerase type I activity (molecular function)
InterPro domains	IPR000380 - DNA topoisomerase, type IA IPR003601 - DNA topoisomerase, type IA, domain 2 IPR003602 - DNA topoisomerase, type IA, DNA-binding domain IPR006171 - TOPRIM domain IPR013497 - DNA topoisomerase, type IA, central IPR013824 - DNA topoisomerase, type IA, central region, subdomain 1 IPR013825 - DNA topoisomerase, type IA, central region, subdomain 2 IPR013826 - DNA topoisomerase, type IA, central region, subdomain 3 IPR023405 - DNA topoisomerase, type IA, core domain IPR023406 - DNA topoisomerase, type IA, active site IPR034144 - DNA topoisomerase 3-like, TOPRIM domain

Homology

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GenBank top hits

e value

%identity

Alignment

KAA0067650.1 DNA topoisomerase 3-beta [Cucumis melo var. makuwa]

0.0e+00

94.48

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Query:  VCIRIIIVAEKPSIALSIASALSHGQMSTRKGSTEVHEFDGRFLGHHAYYKVTSVIGHIFSIDFPAGFQDWKTTDPLDLFQASVIKTESNPKAHIRQHLS
        V   +++VAEKPSIALSIASALSHGQMSTRKGSTEVHEFDGRFLGHHAYYKVTSVIGHIFSIDF AGFQDWKTT+PLDLFQASVIKTESNPKAHIRQHLS
Subjt:  VCIRIIIVAEKPSIALSIASALSHGQMSTRKGSTEVHEFDGRFLGHHAYYKVTSVIGHIFSIDFPAGFQDWKTTDPLDLFQASVIKTESNPKAHIRQHLS

Query:  REARGCDCLVLWLDCDREGENICFEVIECTGFGGNGTRKKVYRARFSSVTEKDILKALDNLVQPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYGN
        REARGCDCLVLWLDCDREGENICFEVIECTGFGGNGTRKKVYRARFSSVTEKDILKALDNLV+PNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYGN
Subjt:  REARGCDCLVLWLDCDREGENICFEVIECTGFGGNGTRKKVYRARFSSVTEKDILKALDNLVQPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYGN

Query:  LDSRLISYGPCQTPTLGFCVQRHLQITTFKPENFGLYALILCKTA--MNLIWTGNVASYSTVTAMFQKRVIEDGIAEVTEILEKQENKVRPSGLNTVNLL
        LDSRLISYGPCQTPTLGFCVQRHLQITTFKPE F      + +    +NL W         VTAMFQKRVIEDGIAEVTEI EKQENKVRPSGLNTVNLL
Subjt:  LDSRLISYGPCQTPTLGFCVQRHLQITTFKPENFGLYALILCKTA--MNLIWTGNVASYSTVTAMFQKRVIEDGIAEVTEILEKQENKVRPSGLNTVNLL

Query:  KVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAWR
        KVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMC ATEDMLGRDAWR
Subjt:  KVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAWR

Query:  LYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAVNEKKLPQFLKGEKIDVARVDLYQGNTTPPDYLSESELISLMEKHGI
        LYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAVNEKKLPQFLKGEKI+VARVDLYQGNTTPPDYLSESELISLMEKHGI
Subjt:  LYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAVNEKKLPQFLKGEKIDVARVDLYQGNTTPPDYLSESELISLMEKHGI

Query:  GTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVVQSVLQQFKQKYSYFVKKIDHMDALFE
        GTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVV+SVLQQFKQKYSYFVKKID MDALFE
Subjt:  GTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVVQSVLQQFKQKYSYFVKKIDHMDALFE

Query:  AQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKGAIKLYKELTCPLDNFELLIFSLPGPEGKSFPLCPYCYNSPPFEGISTLYGAS
        AQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKG IKLYKELTCPLDNFELLI SLPGPEGKSFPLCPYCYNSPPFEGI TLYGAS
Subjt:  AQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKGAIKLYKELTCPLDNFELLIFSLPGPEGKSFPLCPYCYNSPPFEGISTLYGAS

Query:  KTNPSSGTSSKGMGMPCFLCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPQGAHRISTTSDKCADCDSTIIEVDFNKKTTPL
        KTNPSSGTSSKGMGMPCFLCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPQGAHRISTTSDKCADCDSTIIEVDFNKKTTPL
Subjt:  KTNPSSGTSSKGMGMPCFLCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPQGAHRISTTSDKCADCDSTIIEVDFNKKTTPL

Query:  EDGATLFVGCILCDEFLHSLLEMKHGKSFFRGRGS--RGRGRGRGRGRGRGGRGRNSGKPMDPKMSFRDF
        EDGATLFVGCILCDEFLHSLLEMKHG SF R R S  RGRGRGRGRGRGRGGRGRNSGKPMDPKMSFRDF
Subjt:  EDGATLFVGCILCDEFLHSLLEMKHGKSFFRGRGS--RGRGRGRGRGRGRGGRGRNSGKPMDPKMSFRDF

XP_004147675.1 DNA topoisomerase 3-beta isoform X1 [Cucumis sativus]

0.0e+00

94.56

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Query:  IIIVAEKPSIALSIASALSHGQMSTRKGSTEVHEFDGRFLGHHAYYKVTSVIGHIFSIDFPAGFQDWKTTDPLDLFQASVIKTESNPKAHIRQHLSREAR
        +++VAEKPSIALSIASALSHGQMSTRKGSTEVHEFDGRFLGHHAYYKVTSVIGH+FSIDF AGFQDWK+TDPLDLFQASVIKTESNPKAHI QHLSREAR
Subjt:  IIIVAEKPSIALSIASALSHGQMSTRKGSTEVHEFDGRFLGHHAYYKVTSVIGHIFSIDFPAGFQDWKTTDPLDLFQASVIKTESNPKAHIRQHLSREAR

Query:  GCDCLVLWLDCDREGENICFEVIECTGFGGNGTRKKVYRARFSSVTEKDILKALDNLVQPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYGNLDSR
        GCDCLVLWLDCDREGENICFEVIECTGFGGNGTRKKVYRARFSSVTEKDILKALDNLV+PNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYGNLDSR
Subjt:  GCDCLVLWLDCDREGENICFEVIECTGFGGNGTRKKVYRARFSSVTEKDILKALDNLVQPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYGNLDSR

Query:  LISYGPCQTPTLGFCVQRHLQITTFKPENFGLYALILCKTA--MNLIWTGNVASYSTVTAMFQKRVIEDGIAEVTEILEKQENKVRPSGLNTVNLLKVAS
        LISYGPCQTPTLGFCVQRHLQITTFKPE F      + +T   +NL W         VTAMFQKRVIEDGIAEVTEI EKQENKVRPSGLNTVNLLKVAS
Subjt:  LISYGPCQTPTLGFCVQRHLQITTFKPENFGLYALILCKTA--MNLIWTGNVASYSTVTAMFQKRVIEDGIAEVTEILEKQENKVRPSGLNTVNLLKVAS

Query:  SALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAWRLYQY
        SALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAWRLYQY
Subjt:  SALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAWRLYQY

Query:  VCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAVNEKKLPQFLKGEKIDVARVDLYQGNTTPPDYLSESELISLMEKHGIGTDA
        VCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAVNEKKLPQFLKGEKI+VARVDLYQGNTTPPDYLSESELISLMEKHGIGTDA
Subjt:  VCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAVNEKKLPQFLKGEKIDVARVDLYQGNTTPPDYLSESELISLMEKHGIGTDA

Query:  SIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVVQSVLQQFKQKYSYFVKKIDHMDALFEAQFS
        SIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVVQSVLQQF+QKYSYFVKKIDHMDALFEAQFS
Subjt:  SIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVVQSVLQQFKQKYSYFVKKIDHMDALFEAQFS

Query:  PLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKGAIKLYKELTCPLDNFELLIFSLPGPEGKSFPLCPYCYNSPPFEGISTLYGASKTNP
        PLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKG IKLYKELTCPLDNFELLI+SLPGPEGKSFPLCPYCYNSPPFEGI+TLYGASK NP
Subjt:  PLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKGAIKLYKELTCPLDNFELLIFSLPGPEGKSFPLCPYCYNSPPFEGISTLYGASKTNP

Query:  SSGTSSKGMGMPCFLCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPQGAHRISTTSDKCADCDSTIIEVDFNKKTTPLEDGA
        SSGTSSKGMGMPCF+CPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLP+GAHRISTT DKCADCDSTIIEVDFNKKTTPLEDGA
Subjt:  SSGTSSKGMGMPCFLCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPQGAHRISTTSDKCADCDSTIIEVDFNKKTTPLEDGA

Query:  TLFVGCILCDEFLHSLLEMKHGKSFFRGRGSRGRGRGRGRGRGRGGRGRNSGKPMDPKMSFRDF
        TLFVGCILCDEFLHSLLEMKHGKSF R RGS  RGRGRGRGRGRGGRGR+SGKPMDPKMSFRDF
Subjt:  TLFVGCILCDEFLHSLLEMKHGKSFFRGRGSRGRGRGRGRGRGRGGRGRNSGKPMDPKMSFRDF

XP_008439059.1 PREDICTED: DNA topoisomerase 3-beta [Cucumis melo]

0.0e+00

94.7

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Query:  VCIRIIIVAEKPSIALSIASALSHGQMSTRKGSTEVHEFDGRFLGHHAYYKVTSVIGHIFSIDFPAGFQDWKTTDPLDLFQASVIKTESNPKAHIRQHLS
        V   +++VAEKPSIALSIASALSHGQMSTRKGSTEVHEFDGRFLGHHAYYKVTSVIGHIFSIDF AGFQDWKTT+PLDLFQASVIKTESNPKAHIRQHLS
Subjt:  VCIRIIIVAEKPSIALSIASALSHGQMSTRKGSTEVHEFDGRFLGHHAYYKVTSVIGHIFSIDFPAGFQDWKTTDPLDLFQASVIKTESNPKAHIRQHLS

Query:  REARGCDCLVLWLDCDREGENICFEVIECTGFGGNGTRKKVYRARFSSVTEKDILKALDNLVQPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYGN
        REARGCDCLVLWLDCDREGENICFEVIECTGFGGNGTRKKVYRARFSSVTEKDILKALDNLV+PNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYGN
Subjt:  REARGCDCLVLWLDCDREGENICFEVIECTGFGGNGTRKKVYRARFSSVTEKDILKALDNLVQPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYGN

Query:  LDSRLISYGPCQTPTLGFCVQRHLQITTFKPENFGLYALILCKTA--MNLIWTGNVASYSTVTAMFQKRVIEDGIAEVTEILEKQENKVRPSGLNTVNLL
        LDSRLISYGPCQTPTLGFCVQRHLQITTFKPE F      + +    +NL W         VTAMFQKRVIEDGIAEVTEI EKQENKVRPSGLNTVNLL
Subjt:  LDSRLISYGPCQTPTLGFCVQRHLQITTFKPENFGLYALILCKTA--MNLIWTGNVASYSTVTAMFQKRVIEDGIAEVTEILEKQENKVRPSGLNTVNLL

Query:  KVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAWR
        KVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMC ATEDMLGRDAWR
Subjt:  KVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAWR

Query:  LYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAVNEKKLPQFLKGEKIDVARVDLYQGNTTPPDYLSESELISLMEKHGI
        LYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAVNEKKLPQFLKGEKI+VARVDLYQGNTTPPDYLSESELISLMEKHGI
Subjt:  LYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAVNEKKLPQFLKGEKIDVARVDLYQGNTTPPDYLSESELISLMEKHGI

Query:  GTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVVQSVLQQFKQKYSYFVKKIDHMDALFE
        GTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVV+SVLQQFKQKYSYFVKKID MDALFE
Subjt:  GTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVVQSVLQQFKQKYSYFVKKIDHMDALFE

Query:  AQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKGAIKLYKELTCPLDNFELLIFSLPGPEGKSFPLCPYCYNSPPFEGISTLYGAS
        AQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKG IKLYKELTCPLDNFELLI SLPGPEGKSFPLCPYCYNSPPFEGI TLYGAS
Subjt:  AQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKGAIKLYKELTCPLDNFELLIFSLPGPEGKSFPLCPYCYNSPPFEGISTLYGAS

Query:  KTNPSSGTSSKGMGMPCFLCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPQGAHRISTTSDKCADCDSTIIEVDFNKKTTPL
        KTNPSSGTSSKGMGMPCFLCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPQGAHRISTTSDKCADCDSTIIEVDFNKKTTPL
Subjt:  KTNPSSGTSSKGMGMPCFLCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPQGAHRISTTSDKCADCDSTIIEVDFNKKTTPL

Query:  EDGATLFVGCILCDEFLHSLLEMKHGKSFFRGRGSRGRGRGRGRGRGRGGRGRNSGKPMDPKMSFRDF
        EDGATLFVGCILCDEFLHSLLEMKHG SF R R SRGRGRGRGRGRGRGGRGRNSGKPMDPKMSFRDF
Subjt:  EDGATLFVGCILCDEFLHSLLEMKHGKSFFRGRGSRGRGRGRGRGRGRGGRGRNSGKPMDPKMSFRDF

XP_023528530.1 DNA topoisomerase 3-beta isoform X1 [Cucurbita pepo subsp. pepo]

0.0e+00

91.36

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Query:  VCIRIIIVAEKPSIALSIASALSHGQMSTRKGSTEVHEFDGRFLGHHAYYKVTSVIGHIFSIDFPAGFQDWKTTDPLDLFQASVIKTESNPKAHIRQHLS
        V   +++VAEKPSIALSIASALSHGQMSTRKGSTEVHEFDGRFLGHHA+YKVTSVIGH+FSIDFPA FQDWK TDPLDLFQASVIK ESNPKAHIRQHLS
Subjt:  VCIRIIIVAEKPSIALSIASALSHGQMSTRKGSTEVHEFDGRFLGHHAYYKVTSVIGHIFSIDFPAGFQDWKTTDPLDLFQASVIKTESNPKAHIRQHLS

Query:  REARGCDCLVLWLDCDREGENICFEVIECTGFGGNGTRKKVYRARFSSVTEKDILKALDNLVQPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYGN
        REARGCDCLVLWLDCDREGENICFEVIECTGFGGN  RKKVYRARFSSVTEKDILKALDNLV+PNRNEALAVDARQEIDLKVGV+FTRFQTTFFQGKYGN
Subjt:  REARGCDCLVLWLDCDREGENICFEVIECTGFGGNGTRKKVYRARFSSVTEKDILKALDNLVQPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYGN

Query:  LDSRLISYGPCQTPTLGFCVQRHLQITTFKPENFGLYALILCKTA--MNLIWTGNVASYSTVTAMFQKRVIEDGIAEVTEILEKQENKVRPSGLNTVNLL
        LDSRLISYGPCQTPTLGFCVQRHLQITTFKPE F      + +    +NL W         V  MFQKRV+EDGIAEVT+I EKQE+KVRPSGLNTVNLL
Subjt:  LDSRLISYGPCQTPTLGFCVQRHLQITTFKPENFGLYALILCKTA--MNLIWTGNVASYSTVTAMFQKRVIEDGIAEVTEILEKQENKVRPSGLNTVNLL

Query:  KVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAWR
        KVASSALG+GPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLH+LVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPM LATEDM+GRDAWR
Subjt:  KVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAWR

Query:  LYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAVNEKKLPQFLKGEKIDVARVDLYQGNTTPPDYLSESELISLMEKHGI
        LYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGS V VKGFTSIMPWLAVNEKKLPQFLKG+KI+VA+VDLYQGNT+PPDYLSESELISLMEKHGI
Subjt:  LYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAVNEKKLPQFLKGEKIDVARVDLYQGNTTPPDYLSESELISLMEKHGI

Query:  GTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVVQSVLQQFKQKYSYFVKKIDHMDALFE
        GTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIE QIT VAKGQADH SVVQ+VLQQFKQKYSYFVKKIDHMDALFE
Subjt:  GTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVVQSVLQQFKQKYSYFVKKIDHMDALFE

Query:  AQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKGAIKLYKELTCPLDNFELLIFSLPGPEGKSFPLCPYCYNSPPFEGISTLYGAS
        AQFSPLA+SGRALSKCGKCLRYMKFISSQPQRLYCG CEEVYYLPQ+GAIKLYKELTCPLDNFELLIFSLPGPEGKSFPLCPYCYNSPPFEGI TLYGA+
Subjt:  AQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKGAIKLYKELTCPLDNFELLIFSLPGPEGKSFPLCPYCYNSPPFEGISTLYGAS

Query:  KTNPSSGTSSKGMGMPCFLCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPQGAHRISTTSDKCADCDSTIIEVDFNKKTTPL
        KTNPSSG SSKGMGMPCFLCPHPTCRHSLITQGVCACPECSGTLVLDPV APNWKLNCNKCNCLVFLPQGAHRI+TT++KCA+CDSTIIEVDFNKKTTPL
Subjt:  KTNPSSGTSSKGMGMPCFLCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPQGAHRISTTSDKCADCDSTIIEVDFNKKTTPL

Query:  EDGATLFVGCILCDEFLHSLLEMKHGKSFFRGRGSRGRGRGRGRGRGRGGRGRNSGKPMDPKMSFRDF
        E GATLFVGCILCDEFLHSLLEMKHGKSFFRGRGSRGRGRGRGRGRGR GRGR+SGK MDPKMSFRDF
Subjt:  EDGATLFVGCILCDEFLHSLLEMKHGKSFFRGRGSRGRGRGRGRGRGRGGRGRNSGKPMDPKMSFRDF

XP_038891105.1 DNA topoisomerase 3-beta isoform X1 [Benincasa hispida]

0.0e+00

92.74

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Query:  VCIRIIIVAEKPSIALSIASALSHGQMSTRKGSTEVHEFDGRFLGHHAYYKVTSVIGHIFSIDFPAGFQDWKTTDPLDLFQASVIKTESNPKAHIRQHLS
        V   +++VAEKPSIALSIASALSHGQMSTRKGST+VHEFDGRFLGHHA+YKVTSVIGH+FSIDFPAGFQDWK+TDPLDLFQASVIKTESNPKAHIRQHLS
Subjt:  VCIRIIIVAEKPSIALSIASALSHGQMSTRKGSTEVHEFDGRFLGHHAYYKVTSVIGHIFSIDFPAGFQDWKTTDPLDLFQASVIKTESNPKAHIRQHLS

Query:  REARGCDCLVLWLDCDREGENICFEVIECTGFGGNGTRKKVYRARFSSVTEKDILKALDNLVQPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYGN
        REARGCDCLVLWLDCDREGENICFEVIECTGFGGN  RKKVYRARFSSVTEKDILKALDNLVQPN+NEALAVDARQEIDLKVGVAFTRFQTTFFQGKYGN
Subjt:  REARGCDCLVLWLDCDREGENICFEVIECTGFGGNGTRKKVYRARFSSVTEKDILKALDNLVQPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYGN

Query:  LDSRLISYGPCQTPTLGFCVQRHLQITTFKPENFGLYALILCKTA--MNLIWTGNVASYSTVTAMFQKRVIEDGIAEVTEILEKQENKVRPSGLNTVNLL
        LDSRLISYGPCQTPTLGFCVQRHLQITTF PE F      + +    +NL W         VTAMFQKRVIEDGIAEVTEI EKQENKVRPSGLNTVNLL
Subjt:  LDSRLISYGPCQTPTLGFCVQRHLQITTFKPENFGLYALILCKTA--MNLIWTGNVASYSTVTAMFQKRVIEDGIAEVTEILEKQENKVRPSGLNTVNLL

Query:  KVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAWR
        KVASSALGFGPQ+AMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTL+KN EWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAWR
Subjt:  KVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAWR

Query:  LYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAVNEKKLPQFLKGEKIDVARVDLYQGNTTPPDYLSESELISLMEKHGI
        LYQYVCQHFIGSLSSDCKYIRTKIQFSIAGE+FNCTGSRV VKGFTSIMPWLAVNEKKLPQFLKGEKI+VARVDLYQGNTTPPDYLSESELISLMEKHGI
Subjt:  LYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAVNEKKLPQFLKGEKIDVARVDLYQGNTTPPDYLSESELISLMEKHGI

Query:  GTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVVQSVLQQFKQKYSYFVKKIDHMDALFE
        GTDASIPVHINNIGERNYVQVQAGRRL PTNLGITL+RGYQCIDPDLCLPDIRSFIE QITLVAKGQADHSSVVQ+VLQQFKQKY YFVKKIDHMDALFE
Subjt:  GTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVVQSVLQQFKQKYSYFVKKIDHMDALFE

Query:  AQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKGAIKLYKELTCPLDNFELLIFSLPGPEGKSFPLCPYCYNSPPFEGISTLYGAS
        AQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKGAIKLYKELTCPLDNFELLIFSLPGPEGKSFPLCPYCYNSPPFEGI TLYGA+
Subjt:  AQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKGAIKLYKELTCPLDNFELLIFSLPGPEGKSFPLCPYCYNSPPFEGISTLYGAS

Query:  KTNPSSGTSSKGMGMPCFLCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPQGAHRISTTSDKCADCDSTIIEVDFNKKTTPL
        KTNPSSG SSKGMGMPCFLC HPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPQGAHRIST ++KCADCDSTIIEVDFNKKTTPL
Subjt:  KTNPSSGTSSKGMGMPCFLCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPQGAHRISTTSDKCADCDSTIIEVDFNKKTTPL

Query:  EDGATLFVGCILCDEFLHSLLEMKHGKSFFRGRGSRGRGRGRGRGRGRGGRGRNSGKPMDPKMSFRDF
        E GATLFVGCILCDEFLHSLLEMKHGKS FRGRGSRGRGRGRGRG GR GRGRNSG+PMDPKMSFRDF
Subjt:  EDGATLFVGCILCDEFLHSLLEMKHGKSFFRGRGSRGRGRGRGRGRGRGGRGRNSGKPMDPKMSFRDF

TrEMBL top hits

e value

%identity

Alignment

A0A0A0L9C7 DNA topoisomerase

0.0e+00

94.56

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Query:  IIIVAEKPSIALSIASALSHGQMSTRKGSTEVHEFDGRFLGHHAYYKVTSVIGHIFSIDFPAGFQDWKTTDPLDLFQASVIKTESNPKAHIRQHLSREAR
        +++VAEKPSIALSIASALSHGQMSTRKGSTEVHEFDGRFLGHHAYYKVTSVIGH+FSIDF AGFQDWK+TDPLDLFQASVIKTESNPKAHI QHLSREAR
Subjt:  IIIVAEKPSIALSIASALSHGQMSTRKGSTEVHEFDGRFLGHHAYYKVTSVIGHIFSIDFPAGFQDWKTTDPLDLFQASVIKTESNPKAHIRQHLSREAR

Query:  GCDCLVLWLDCDREGENICFEVIECTGFGGNGTRKKVYRARFSSVTEKDILKALDNLVQPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYGNLDSR
        GCDCLVLWLDCDREGENICFEVIECTGFGGNGTRKKVYRARFSSVTEKDILKALDNLV+PNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYGNLDSR
Subjt:  GCDCLVLWLDCDREGENICFEVIECTGFGGNGTRKKVYRARFSSVTEKDILKALDNLVQPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYGNLDSR

Query:  LISYGPCQTPTLGFCVQRHLQITTFKPENFGLYALILCKTA--MNLIWTGNVASYSTVTAMFQKRVIEDGIAEVTEILEKQENKVRPSGLNTVNLLKVAS
        LISYGPCQTPTLGFCVQRHLQITTFKPE F      + +T   +NL W         VTAMFQKRVIEDGIAEVTEI EKQENKVRPSGLNTVNLLKVAS
Subjt:  LISYGPCQTPTLGFCVQRHLQITTFKPENFGLYALILCKTA--MNLIWTGNVASYSTVTAMFQKRVIEDGIAEVTEILEKQENKVRPSGLNTVNLLKVAS

Query:  SALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAWRLYQY
        SALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAWRLYQY
Subjt:  SALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAWRLYQY

Query:  VCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAVNEKKLPQFLKGEKIDVARVDLYQGNTTPPDYLSESELISLMEKHGIGTDA
        VCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAVNEKKLPQFLKGEKI+VARVDLYQGNTTPPDYLSESELISLMEKHGIGTDA
Subjt:  VCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAVNEKKLPQFLKGEKIDVARVDLYQGNTTPPDYLSESELISLMEKHGIGTDA

Query:  SIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVVQSVLQQFKQKYSYFVKKIDHMDALFEAQFS
        SIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVVQSVLQQF+QKYSYFVKKIDHMDALFEAQFS
Subjt:  SIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVVQSVLQQFKQKYSYFVKKIDHMDALFEAQFS

Query:  PLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKGAIKLYKELTCPLDNFELLIFSLPGPEGKSFPLCPYCYNSPPFEGISTLYGASKTNP
        PLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKG IKLYKELTCPLDNFELLI+SLPGPEGKSFPLCPYCYNSPPFEGI+TLYGASK NP
Subjt:  PLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKGAIKLYKELTCPLDNFELLIFSLPGPEGKSFPLCPYCYNSPPFEGISTLYGASKTNP

Query:  SSGTSSKGMGMPCFLCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPQGAHRISTTSDKCADCDSTIIEVDFNKKTTPLEDGA
        SSGTSSKGMGMPCF+CPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLP+GAHRISTT DKCADCDSTIIEVDFNKKTTPLEDGA
Subjt:  SSGTSSKGMGMPCFLCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPQGAHRISTTSDKCADCDSTIIEVDFNKKTTPLEDGA

Query:  TLFVGCILCDEFLHSLLEMKHGKSFFRGRGSRGRGRGRGRGRGRGGRGRNSGKPMDPKMSFRDF
        TLFVGCILCDEFLHSLLEMKHGKSF R RGS  RGRGRGRGRGRGGRGR+SGKPMDPKMSFRDF
Subjt:  TLFVGCILCDEFLHSLLEMKHGKSFFRGRGSRGRGRGRGRGRGRGGRGRNSGKPMDPKMSFRDF

A0A1S3AYH7 DNA topoisomerase

0.0e+00

94.7

Show/hide

Query:  VCIRIIIVAEKPSIALSIASALSHGQMSTRKGSTEVHEFDGRFLGHHAYYKVTSVIGHIFSIDFPAGFQDWKTTDPLDLFQASVIKTESNPKAHIRQHLS
        V   +++VAEKPSIALSIASALSHGQMSTRKGSTEVHEFDGRFLGHHAYYKVTSVIGHIFSIDF AGFQDWKTT+PLDLFQASVIKTESNPKAHIRQHLS
Subjt:  VCIRIIIVAEKPSIALSIASALSHGQMSTRKGSTEVHEFDGRFLGHHAYYKVTSVIGHIFSIDFPAGFQDWKTTDPLDLFQASVIKTESNPKAHIRQHLS

Query:  REARGCDCLVLWLDCDREGENICFEVIECTGFGGNGTRKKVYRARFSSVTEKDILKALDNLVQPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYGN
        REARGCDCLVLWLDCDREGENICFEVIECTGFGGNGTRKKVYRARFSSVTEKDILKALDNLV+PNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYGN
Subjt:  REARGCDCLVLWLDCDREGENICFEVIECTGFGGNGTRKKVYRARFSSVTEKDILKALDNLVQPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYGN

Query:  LDSRLISYGPCQTPTLGFCVQRHLQITTFKPENFGLYALILCKTA--MNLIWTGNVASYSTVTAMFQKRVIEDGIAEVTEILEKQENKVRPSGLNTVNLL
        LDSRLISYGPCQTPTLGFCVQRHLQITTFKPE F      + +    +NL W         VTAMFQKRVIEDGIAEVTEI EKQENKVRPSGLNTVNLL
Subjt:  LDSRLISYGPCQTPTLGFCVQRHLQITTFKPENFGLYALILCKTA--MNLIWTGNVASYSTVTAMFQKRVIEDGIAEVTEILEKQENKVRPSGLNTVNLL

Query:  KVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAWR
        KVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMC ATEDMLGRDAWR
Subjt:  KVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAWR

Query:  LYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAVNEKKLPQFLKGEKIDVARVDLYQGNTTPPDYLSESELISLMEKHGI
        LYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAVNEKKLPQFLKGEKI+VARVDLYQGNTTPPDYLSESELISLMEKHGI
Subjt:  LYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAVNEKKLPQFLKGEKIDVARVDLYQGNTTPPDYLSESELISLMEKHGI

Query:  GTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVVQSVLQQFKQKYSYFVKKIDHMDALFE
        GTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVV+SVLQQFKQKYSYFVKKID MDALFE
Subjt:  GTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVVQSVLQQFKQKYSYFVKKIDHMDALFE

Query:  AQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKGAIKLYKELTCPLDNFELLIFSLPGPEGKSFPLCPYCYNSPPFEGISTLYGAS
        AQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKG IKLYKELTCPLDNFELLI SLPGPEGKSFPLCPYCYNSPPFEGI TLYGAS
Subjt:  AQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKGAIKLYKELTCPLDNFELLIFSLPGPEGKSFPLCPYCYNSPPFEGISTLYGAS

Query:  KTNPSSGTSSKGMGMPCFLCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPQGAHRISTTSDKCADCDSTIIEVDFNKKTTPL
        KTNPSSGTSSKGMGMPCFLCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPQGAHRISTTSDKCADCDSTIIEVDFNKKTTPL
Subjt:  KTNPSSGTSSKGMGMPCFLCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPQGAHRISTTSDKCADCDSTIIEVDFNKKTTPL

Query:  EDGATLFVGCILCDEFLHSLLEMKHGKSFFRGRGSRGRGRGRGRGRGRGGRGRNSGKPMDPKMSFRDF
        EDGATLFVGCILCDEFLHSLLEMKHG SF R R SRGRGRGRGRGRGRGGRGRNSGKPMDPKMSFRDF
Subjt:  EDGATLFVGCILCDEFLHSLLEMKHGKSFFRGRGSRGRGRGRGRGRGRGGRGRNSGKPMDPKMSFRDF

A0A5A7VKD3 DNA topoisomerase

0.0e+00

94.48

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Query:  VCIRIIIVAEKPSIALSIASALSHGQMSTRKGSTEVHEFDGRFLGHHAYYKVTSVIGHIFSIDFPAGFQDWKTTDPLDLFQASVIKTESNPKAHIRQHLS
        V   +++VAEKPSIALSIASALSHGQMSTRKGSTEVHEFDGRFLGHHAYYKVTSVIGHIFSIDF AGFQDWKTT+PLDLFQASVIKTESNPKAHIRQHLS
Subjt:  VCIRIIIVAEKPSIALSIASALSHGQMSTRKGSTEVHEFDGRFLGHHAYYKVTSVIGHIFSIDFPAGFQDWKTTDPLDLFQASVIKTESNPKAHIRQHLS

Query:  REARGCDCLVLWLDCDREGENICFEVIECTGFGGNGTRKKVYRARFSSVTEKDILKALDNLVQPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYGN
        REARGCDCLVLWLDCDREGENICFEVIECTGFGGNGTRKKVYRARFSSVTEKDILKALDNLV+PNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYGN
Subjt:  REARGCDCLVLWLDCDREGENICFEVIECTGFGGNGTRKKVYRARFSSVTEKDILKALDNLVQPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYGN

Query:  LDSRLISYGPCQTPTLGFCVQRHLQITTFKPENFGLYALILCKTA--MNLIWTGNVASYSTVTAMFQKRVIEDGIAEVTEILEKQENKVRPSGLNTVNLL
        LDSRLISYGPCQTPTLGFCVQRHLQITTFKPE F      + +    +NL W         VTAMFQKRVIEDGIAEVTEI EKQENKVRPSGLNTVNLL
Subjt:  LDSRLISYGPCQTPTLGFCVQRHLQITTFKPENFGLYALILCKTA--MNLIWTGNVASYSTVTAMFQKRVIEDGIAEVTEILEKQENKVRPSGLNTVNLL

Query:  KVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAWR
        KVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMC ATEDMLGRDAWR
Subjt:  KVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAWR

Query:  LYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAVNEKKLPQFLKGEKIDVARVDLYQGNTTPPDYLSESELISLMEKHGI
        LYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAVNEKKLPQFLKGEKI+VARVDLYQGNTTPPDYLSESELISLMEKHGI
Subjt:  LYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAVNEKKLPQFLKGEKIDVARVDLYQGNTTPPDYLSESELISLMEKHGI

Query:  GTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVVQSVLQQFKQKYSYFVKKIDHMDALFE
        GTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVV+SVLQQFKQKYSYFVKKID MDALFE
Subjt:  GTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVVQSVLQQFKQKYSYFVKKIDHMDALFE

Query:  AQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKGAIKLYKELTCPLDNFELLIFSLPGPEGKSFPLCPYCYNSPPFEGISTLYGAS
        AQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKG IKLYKELTCPLDNFELLI SLPGPEGKSFPLCPYCYNSPPFEGI TLYGAS
Subjt:  AQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKGAIKLYKELTCPLDNFELLIFSLPGPEGKSFPLCPYCYNSPPFEGISTLYGAS

Query:  KTNPSSGTSSKGMGMPCFLCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPQGAHRISTTSDKCADCDSTIIEVDFNKKTTPL
        KTNPSSGTSSKGMGMPCFLCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPQGAHRISTTSDKCADCDSTIIEVDFNKKTTPL
Subjt:  KTNPSSGTSSKGMGMPCFLCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPQGAHRISTTSDKCADCDSTIIEVDFNKKTTPL

Query:  EDGATLFVGCILCDEFLHSLLEMKHGKSFFRGRGS--RGRGRGRGRGRGRGGRGRNSGKPMDPKMSFRDF
        EDGATLFVGCILCDEFLHSLLEMKHG SF R R S  RGRGRGRGRGRGRGGRGRNSGKPMDPKMSFRDF
Subjt:  EDGATLFVGCILCDEFLHSLLEMKHGKSFFRGRGS--RGRGRGRGRGRGRGGRGRNSGKPMDPKMSFRDF

A0A6J1GWS0 DNA topoisomerase

0.0e+00

91.01

Show/hide

Query:  VCIRIIIVAEKPSIALSIASALSHGQMSTRKGSTEVHEFDGRFLGHHAYYKVTSVIGHIFSIDFPAGFQDWKTTDPLDLFQASVIKTESNPKAHIRQHLS
        V   +++VAEKPSIALSIASALSHGQMSTRKGSTEVHEFDGRFLGHHA+YKVTSVIGH+FSIDFPA FQDWK TDPLDLFQASVIKTESNPKAHIRQHLS
Subjt:  VCIRIIIVAEKPSIALSIASALSHGQMSTRKGSTEVHEFDGRFLGHHAYYKVTSVIGHIFSIDFPAGFQDWKTTDPLDLFQASVIKTESNPKAHIRQHLS

Query:  REARGCDCLVLWLDCDREGENICFEVIECTGFGGNGTRKKVYRARFSSVTEKDILKALDNLVQPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYGN
        REARGCDCLVLWLDCDREGENICFEVIECTGFGGN  RKKVYRARFSSVTEKDILKALDNLV+PNRNEALAVDARQEIDLKVGV+FTRFQTTFFQGKYGN
Subjt:  REARGCDCLVLWLDCDREGENICFEVIECTGFGGNGTRKKVYRARFSSVTEKDILKALDNLVQPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYGN

Query:  LDSRLISYGPCQTPTLGFCVQRHLQITTFKPENFGLYALILCKTA--MNLIWTGNVASYSTVTAMFQKRVIEDGIAEVTEILEKQENKVRPSGLNTVNLL
        LDSRLISYGPCQTPTLGFCVQRHLQITTFKPE F      + +    +NL W         V  MFQKRV+EDGIAEVT+I EKQE+KVRPSGLNTVNLL
Subjt:  LDSRLISYGPCQTPTLGFCVQRHLQITTFKPENFGLYALILCKTA--MNLIWTGNVASYSTVTAMFQKRVIEDGIAEVTEILEKQENKVRPSGLNTVNLL

Query:  KVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAWR
        KVASSALG+GPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLH+LVKNPEWGDYVR+LLSDGYSKPRSGTDVGDHPPITPM LATEDM+GRDAWR
Subjt:  KVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAWR

Query:  LYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAVNEKKLPQFLKGEKIDVARVDLYQGNTTPPDYLSESELISLMEKHGI
        LYQYVCQHFIGSLSSDCKY+RTKIQFSIAGEIFNCTGS V VKGFTSIMPWLAVNEKKLPQFLKG+KI+VA+VDLYQGNT+PPDYLSESELISLMEKHGI
Subjt:  LYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAVNEKKLPQFLKGEKIDVARVDLYQGNTTPPDYLSESELISLMEKHGI

Query:  GTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVVQSVLQQFKQKYSYFVKKIDHMDALFE
        GTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIE QIT VAKGQADH SVVQ+VLQQFKQKYSYFVKKIDHMDALFE
Subjt:  GTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVVQSVLQQFKQKYSYFVKKIDHMDALFE

Query:  AQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKGAIKLYKELTCPLDNFELLIFSLPGPEGKSFPLCPYCYNSPPFEGISTLYGAS
        AQFSPLA+SGRALSKCGKCLRYMKFISSQPQRLYCG CEEVYYLPQ+GAIKLYKELTCPLDNFELLIFSLPGPEGKSFPLCPYCYNSPPFEGI TLYGA+
Subjt:  AQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKGAIKLYKELTCPLDNFELLIFSLPGPEGKSFPLCPYCYNSPPFEGISTLYGAS

Query:  KTNPSSGTSSKGMGMPCFLCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPQGAHRISTTSDKCADCDSTIIEVDFNKKTTPL
        KTNPSSG SSKGMGMPCFLCPHPTCRHSLITQGVCACPECSGTLVLDPV APNWKLNCNKCNCLVFLPQGAHRI+TT++KCA+CDSTIIEVDFNKKTTPL
Subjt:  KTNPSSGTSSKGMGMPCFLCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPQGAHRISTTSDKCADCDSTIIEVDFNKKTTPL

Query:  EDGATLFVGCILCDEFLHSLLEMKHGKSFFRGRGSRGRGRGRGRGRGRGGRGRNSGKPMDPKMSFRDF
        E GATLFVGCILCDEFLHSLLEMKHGKSFFRGRGSRGRGRGRGRGR   GRGR+SGK MDPKMSFRDF
Subjt:  EDGATLFVGCILCDEFLHSLLEMKHGKSFFRGRGSRGRGRGRGRGRGRGGRGRNSGKPMDPKMSFRDF

A0A6J1IRJ0 DNA topoisomerase

0.0e+00

91.13

Show/hide

Query:  VCIRIIIVAEKPSIALSIASALSHGQMSTRKGSTEVHEFDGRFLGHHAYYKVTSVIGHIFSIDFPAGFQDWKTTDPLDLFQASVIKTESNPKAHIRQHLS
        V   +++VAEKPSIALSIASALSHGQMSTRKGSTEVHEFDGRFLGHHA+YKVTSVIGH+FSIDFPA FQDWK TDPLDLFQASVIKTESNPKAHIRQHLS
Subjt:  VCIRIIIVAEKPSIALSIASALSHGQMSTRKGSTEVHEFDGRFLGHHAYYKVTSVIGHIFSIDFPAGFQDWKTTDPLDLFQASVIKTESNPKAHIRQHLS

Query:  REARGCDCLVLWLDCDREGENICFEVIECTGFGGNGTRKKVYRARFSSVTEKDILKALDNLVQPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYGN
        REARGCDCLVLWLDCDREGENICFEVIECTGFGGN  RKKVYRARFSSVTEKDILKALDNLV+PNRNEALAVDARQEIDLKVGV+FTRFQTTFFQGKYGN
Subjt:  REARGCDCLVLWLDCDREGENICFEVIECTGFGGNGTRKKVYRARFSSVTEKDILKALDNLVQPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYGN

Query:  LDSRLISYGPCQTPTLGFCVQRHLQITTFKPENFGLYALILCKTA--MNLIWTGNVASYSTVTAMFQKRVIEDGIAEVTEILEKQENKVRPSGLNTVNLL
        LDSRLISYGPCQTPTLGFCVQRHLQITTFKPE F      + +    +NL W         V  MFQKRV+EDGIAEVT+I EKQE+KVRPSGLNTVNLL
Subjt:  LDSRLISYGPCQTPTLGFCVQRHLQITTFKPENFGLYALILCKTA--MNLIWTGNVASYSTVTAMFQKRVIEDGIAEVTEILEKQENKVRPSGLNTVNLL

Query:  KVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAWR
        KVASSALG+GPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLH+LVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPM LATEDM+GRDAWR
Subjt:  KVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAWR

Query:  LYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAVNEKKLPQFLKGEKIDVARVDLYQGNTTPPDYLSESELISLMEKHGI
        LYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGS V VKGFTSIMPWLAVNEKKLPQFLKG+KI+VA+VDLYQGNT+PPDYLSESELISLMEKHGI
Subjt:  LYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAVNEKKLPQFLKGEKIDVARVDLYQGNTTPPDYLSESELISLMEKHGI

Query:  GTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVVQSVLQQFKQKYSYFVKKIDHMDALFE
        GTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIE QIT VAKGQADH SVVQ+VLQQFKQKYSYFVKKIDHMDALFE
Subjt:  GTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVVQSVLQQFKQKYSYFVKKIDHMDALFE

Query:  AQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKGAIKLYKELTCPLDNFELLIFSLPGPEGKSFPLCPYCYNSPPFEGISTLYGAS
        AQFSPLA+SGRALSKCGKCLRYMKFISSQPQRLYCG CEEVYYLPQ+GAIKLYKELTCPLDNFELLIFSLPGPEGKSFPLCPYCYNSPPFEGI  LYGA+
Subjt:  AQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKGAIKLYKELTCPLDNFELLIFSLPGPEGKSFPLCPYCYNSPPFEGISTLYGAS

Query:  KTNPSSGTSSKGMGMPCFLCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPQGAHRISTTSDKCADCDSTIIEVDFNKKTTPL
        KTNPSSG SSKGMGMPCFLCPHPTCRHSLITQGVCACPECSGTLVLDPV APNWKLNCNKCNCLVFLPQGAHRI+TT++KCA+CDSTIIEVDFNKKTTPL
Subjt:  KTNPSSGTSSKGMGMPCFLCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPQGAHRISTTSDKCADCDSTIIEVDFNKKTTPL

Query:  EDGATLFVGCILCDEFLHSLLEMKHGKSFFRGRGSRGRGRGRGRGRGRGGRGRNSGKPMDPKMSFRDF
        E GATLFVGCILCDEFLHSLLEMKHGKSFFRGRGSRGRGRGRGRGR   GRGR+SGK MDPKMSFRDF
Subjt:  EDGATLFVGCILCDEFLHSLLEMKHGKSFFRGRGSRGRGRGRGRGRGRGGRGRNSGKPMDPKMSFRDF

SwissProt top hits

e value

%identity

Alignment

F4ISQ7 DNA topoisomerase 3-beta

0.0e+00

74.48

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Query:  IRIIIVAEKPSIALSIASALSHGQMSTRKGSTEVHEFDGRFLGHHAYYKVTSVIGHIFSIDFPAGFQDWKTTDPLDLFQASVIKTESNPKAHIRQHLSRE
        +R+++VAEKPSIALSIAS LSHGQMSTR+GSTEVHEFDG F G  A+Y+VTSVIGH+FS+DFP  +Q+W T DP DLF A +IK ESNPKAHI +HLS E
Subjt:  IRIIIVAEKPSIALSIASALSHGQMSTRKGSTEVHEFDGRFLGHHAYYKVTSVIGHIFSIDFPAGFQDWKTTDPLDLFQASVIKTESNPKAHIRQHLSRE

Query:  ARGCDCLVLWLDCDREGENICFEVIECTGFGGNGTRKKVYRARFSSVTEKDILKALDNLVQPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYGNLD
        ARGC  +VLWLDCDREGENICFEVIE TGF    +++KVYRARFSSVTEKDI KA+DNLV+PNR+EALAVDARQEIDLKVGVAF+RFQT++FQGKY NLD
Subjt:  ARGCDCLVLWLDCDREGENICFEVIECTGFGGNGTRKKVYRARFSSVTEKDILKALDNLVQPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYGNLD

Query:  SRLISYGPCQTPTLGFCVQRHLQITTFKPENFGLYALILCKTA--MNLIWTGNVASYSTVTAMFQKRVIEDGIAEVTEILEKQENKVRPSGLNTVNLLKV
         R+ISYGPCQTPTLGFCVQR++ I TFKPE F      + K    + L W            +FQK V+E   A+V ++ EKQE K RP+GLNTVNLLKV
Subjt:  SRLISYGPCQTPTLGFCVQRHLQITTFKPENFGLYALILCKTA--MNLIWTGNVASYSTVTAMFQKRVIEDGIAEVTEILEKQENKVRPSGLNTVNLLKV

Query:  ASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAWRLY
        ASSALGFGPQ AM LAERLYTQGFISYPRTESTAYPSSFDF  TL   V NP WG YV+ LLSDG+  P+SGTD GDHPPITPM  ATE M+G DAWRLY
Subjt:  ASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAWRLY

Query:  QYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAVNEKKLPQFLKGEKIDVARVDLYQGNTTPPDYLSESELISLMEKHGIGT
        QYVCQHF+G++S +CKYIRTK++ SI GE F+CTG RVT KGFT+IMPW AV+EKKLP FLKGE+I+V RV+LY+GNT PPDYL+ESELISLMEKHGIGT
Subjt:  QYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAVNEKKLPQFLKGEKIDVARVDLYQGNTTPPDYLSESELISLMEKHGIGT

Query:  DASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVVQSVLQQFKQKYSYFVKKIDHMDALFEAQ
        DASI VHINNIGERNYVQVQ+GR++VPT LGITLIRGYQCIDPDLCLPDIRSFIE QITLVAKGQADHS VVQ V+QQF++K+SYFV++I+HMDALFEAQ
Subjt:  DASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVVQSVLQQFKQKYSYFVKKIDHMDALFEAQ

Query:  FSPLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKGAIKLYKELTCPLDNFELLIFSLPGPEGKSFPLCPYCYNSPPFEGISTLYGASKT
        FSPLADSGRALSKCGKCLRYMK I++ P RL+CG CEEVYYLPQKG +KLYKELTCPLDNFEL+I+S+PGPEGKSFPLCPYCYNSPPFEGI TL+GASKT
Subjt:  FSPLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKGAIKLYKELTCPLDNFELLIFSLPGPEGKSFPLCPYCYNSPPFEGISTLYGASKT

Query:  NPSSGTSSKGMGMPCFLCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPQGAHRISTTSDKCADCDSTIIEVDFNKKTTPLED
          +   +  G GMPC LCPHPTC+HS+  QGVCACPEC GTLVLDPVS P WKLNCN C+C+V LP+GAHRI+TTS++C +CDS IIE+DFNKKTTPLE+
Subjt:  NPSSGTSSKGMGMPCFLCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPQGAHRISTTSDKCADCDSTIIEVDFNKKTTPLED

Query:  GATLFVGCILCDEFLHSLLEMKHGKSFFRGRGSRGRGRGRGRGRGRGGRGRNSGKPMDPKMSFRDF
        GATL  GC+LCDE L SL+E+KHG+SF R RG RGRGRGRGRGRG    GR   K +DPKMSFRDF
Subjt:  GATLFVGCILCDEFLHSLLEMKHGKSFFRGRGSRGRGRGRGRGRGRGGRGRNSGKPMDPKMSFRDF

O95985 DNA topoisomerase 3-beta-1

3.3e-254

51.21

Show/hide

Query:  IIIVAEKPSIALSIASALSHGQMSTRK---GSTEVHEFDGRFLGHHAYYKVTSVIGHIFSIDFPAGFQDWKTTDPLDLF-QASVIKTESNPKAHIRQHLS
        +++VAEKPS+A SIA  LS G +S+ K   G+  VHE+ G F G    +K+TSV GH+ ++DF   +  W   DP +LF QA   K E+NPK ++ + L 
Subjt:  IIIVAEKPSIALSIASALSHGQMSTRK---GSTEVHEFDGRFLGHHAYYKVTSVIGHIFSIDFPAGFQDWKTTDPLDLF-QASVIKTESNPKAHIRQHLS

Query:  REARGCDCLVLWLDCDREGENICFEVIEC---TGFGGNGTRKKVYRARFSSVTEKDILKALDNLVQPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGK
         E RGCD +VLWLDCD+EGENICFEV++         +G  K V+RARFSS+T+ DI  A+  L +P+ NEAL+VDARQE+DL++G AFTRFQT +FQGK
Subjt:  REARGCDCLVLWLDCDREGENICFEVIEC---TGFGGNGTRKKVYRARFSSVTEKDILKALDNLVQPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGK

Query:  YGNLDSRLISYGPCQTPTLGFCVQRHLQITTFKPENFG-LYALILCKTAMNLI--WTGNVASYSTVTAMFQKRVIEDGIAEVTEILEKQENKVRPSGLNT
        YG+LDS LIS+GPCQTPTLGFCV+RH +I +FKPE +  L A +      +L+  W         +  MF      +  A+V     K++ K RP  LNT
Subjt:  YGNLDSRLISYGPCQTPTLGFCVQRHLQITTFKPENFG-LYALILCKTAMNLI--WTGNVASYSTVTAMFQKRVIEDGIAEVTEILEKQENKVRPSGLNT

Query:  VNLLKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGR
        V +L+VASS+LG GPQ AMQ AERLYTQG+ISYPRTE+T YP +FD KG+L     +P W D V+ LL++G ++PR G D GDHPPITPM  ATE  LG 
Subjt:  VNLLKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGR

Query:  DAWRLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAVN-EKKLPQFLKGEKIDVARVDLYQGNTTPPDYLSESELISLM
        DAWRLY+Y+ +HFI ++S DCKY+++ I F I  E+F C+G  V   GFT +MPW +V  E+ LP   +G+   V  V + +  T PPDYL+E+ELI+LM
Subjt:  DAWRLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAVN-EKKLPQFLKGEKIDVARVDLYQGNTTPPDYLSESELISLM

Query:  EKHGIGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVVQSVLQQFKQKYSYFVKKIDHM
        EKHGIGTDASIPVHINNI +RNYV V++GRRL PTNLGI L+ GY  ID +L LP IRS +E Q+ L+A+G+AD+  V+   L  FK+K+ YFV  I  M
Subjt:  EKHGIGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVVQSVLQQFKQKYSYFVKKIDHM

Query:  DALFEAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKGAIKLYKELTCPLDNFELLIFSLPGPEGKSFPLCPYCYNSPPFEGIST
        D L E  FSPLA +G+ LS+CGKC R+MK+I ++P RL+C  C+E Y LPQ G IKLYKEL CPLD+FEL+++S  G  GKS+PLCPYCYN PPF  +  
Subjt:  DALFEAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKGAIKLYKELTCPLDNFELLIFSLPGPEGKSFPLCPYCYNSPPFEGIST

Query:  LYGASKTNPSSGTSSKGMGMPCFLCPHPTCRHSLITQGVCACPEC-SGTLVLDPVSAPNWKLNCNKCNCLVFLPQGAHRISTTSDKCADCDSTIIEVDFN
                       KGMG  C  C HP+C+HSL   G+  C EC SG LVLDP S P WK+ CNKCN +    + AHR+  ++D C+ C++ +++VDFN
Subjt:  LYGASKTNPSSGTSSKGMGMPCFLCPHPTCRHSLITQGVCACPEC-SGTLVLDPVSAPNWKLNCNKCNCLVFLPQGAHRISTTSDKCADCDSTIIEVDFN

Query:  KKTTPLEDGATLFVGCILCDEFLHSLLEMKHGKSFF-RGRGSRGRGRGRGRGRGRGGRGRNSGKPMDPKMS
        K  +PL    T  +GC+ CD     L+E+KH  S     RG  GR +GRGRGR R   G+ + +    KMS
Subjt:  KKTTPLEDGATLFVGCILCDEFLHSLLEMKHGKSFF-RGRGSRGRGRGRGRGRGRGGRGRNSGKPMDPKMS

O96651 DNA topoisomerase 3-beta

2.3e-231

47.66

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Query:  IIIVAEKPSIALSIASALSHGQMSTRKGS---TEVHEFDGRFLGH-HAYYKVTSVIGHIFSIDFPAGFQDWKTTDPLDLFQASVIKTESNPKAHIRQHLS
        +++VAEKPS+A S+A  LS+G+ + ++G+      HE+ G F      ++++TSV GH+ S+DF   +  W   DP+ LF  +  K E+NPK ++R+ L+
Subjt:  IIIVAEKPSIALSIASALSHGQMSTRKGS---TEVHEFDGRFLGH-HAYYKVTSVIGHIFSIDFPAGFQDWKTTDPLDLFQASVIKTESNPKAHIRQHLS

Query:  REARGCDCLVLWLDCDREGENICFEVIECTGFGGNG--TRKKVYRARFSSVTEKDILKALDNLVQPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKY
         EARGCD LVLWLDCD+EGENICFEV++      N   + +  YRA FS++TEKDI KA++ L  PN NEA +VDARQE+DL++G AFTRFQT FFQ +Y
Subjt:  REARGCDCLVLWLDCDREGENICFEVIECTGFGGNG--TRKKVYRARFSSVTEKDILKALDNLVQPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKY

Query:  GNLDSRLISYGPCQTPTLGFCVQRHLQITTFKPENFGLYALILCKTAMNLIWTGNVASYSTVTAMFQKRVIEDGIAEVTEILEKQENKVRPSGLNTVNLL
        G+LDS LISYGPCQTPTLGFCV+RH  I TFKPE+F    L+  +  + L W         +  M   RV E   A V  +  K+  K +P  LNTV L+
Subjt:  GNLDSRLISYGPCQTPTLGFCVQRHLQITTFKPENFGLYALILCKTAMNLIWTGNVASYSTVTAMFQKRVIEDGIAEVTEILEKQENKVRPSGLNTVNLL

Query:  KVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAWR
        ++ SS LG GP  AMQ+AERLYTQG+ISYPRTE+  YP++FD    LH L  + ++G+  R +L D    PR G D GDHPPITPM L       RD WR
Subjt:  KVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAWR

Query:  LYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAV-NEKKLPQFLKGEKIDVARVDLYQGNTTPPDYLSESELISLMEKHG
        +Y+++C+HF+G++S D KY  T  + S+  E F+CT S +   GFT +M W A   ++  P F++G ++ +  V L +  T PPDYL+ESELI+LME+HG
Subjt:  LYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAV-NEKKLPQFLKGEKIDVARVDLYQGNTTPPDYLSESELISLMEKHG

Query:  IGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVVQSVLQQFKQKYSYFVKKIDHMDALF
        IGTDASIPVHINNI +RNYV ++ GR+L+PT LGI L+ GYQ IDP+L LP +R+ +E  +TL+A+G A+   V++  ++ FK K+ YFVK ID MDALF
Subjt:  IGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVVQSVLQQFKQKYSYFVKKIDHMDALF

Query:  EAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKGAIKLYKELTCPLDNFELLIFSLPGPEGKSFPLCPYCYNSPPFEGISTLYGA
        E  FSPLA+SG+A S+CGKC RYMK+I ++P RL+C  C+E Y LP  G +K+Y+E  CPLD+F+LL FS  G +G+S+P CPYCYN PPF  +  L G 
Subjt:  EAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKGAIKLYKELTCPLDNFELLIFSLPGPEGKSFPLCPYCYNSPPFEGISTLYGA

Query:  SKTNPSSGTSSKGMGMPCFLCPHPTCRHSLITQGVCACPEC-SGTLVLDPVSAPNWKLNCNKCNCLVFLPQGAHRISTTSDKCADCDSTIIEVDFNKKTT
                         C  C +  C HSL T G+ +C EC +G LVLD   AP WKL CN+C+ ++   +GA +I+    KC +C +  + V +    +
Subjt:  SKTNPSSGTSSKGMGMPCFLCPHPTCRHSLITQGVCACPEC-SGTLVLDPVSAPNWKLNCNKCNCLVFLPQGAHRISTTSDKCADCDSTIIEVDFNKKTT

Query:  PLEDGATLFVGCILCDEFLHSLLEMKHGKSFFRGRGSRGRGRGRGRGRGRGGRG
          +DG+    GCI C      L+E KH     R   S G  RG   GRG GG G
Subjt:  PLEDGATLFVGCILCDEFLHSLLEMKHGKSFFRGRGSRGRGRGRGRGRGRGGRG

Q0J0S6 DNA topoisomerase 3-beta

0.0e+00

71.64

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Query:  IIIVAEKPSIALSIASALSHGQMSTRKGSTEVHEFDGRFLGHHAYYKVTSVIGHIFSIDFPAGFQDWKTTDPLDLFQASVIKTESNPKAHIRQHLSREAR
        +++VAEKPSIALSIASALS G+MSTRKGST+VHEFDG F G HA++KVTSVIGH+ S+DFP  +Q+W+ TDP+DLF A V+++E NPKAHIR+HL++EAR
Subjt:  IIIVAEKPSIALSIASALSHGQMSTRKGSTEVHEFDGRFLGHHAYYKVTSVIGHIFSIDFPAGFQDWKTTDPLDLFQASVIKTESNPKAHIRQHLSREAR

Query:  GCDCLVLWLDCDREGENICFEVIECTGFGGNGTRKKVYRARFSSVTEKDILKALDNLVQPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYGNLDSR
        GC  LVLWLDCDREGENIC+EVI+CTG   +   ++++RA+FSSVTEKDI+ A++NLV P+++EALAVDARQEIDLKVGVAFTRFQT +FQGKYGNLDSR
Subjt:  GCDCLVLWLDCDREGENICFEVIECTGFGGNGTRKKVYRARFSSVTEKDILKALDNLVQPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYGNLDSR

Query:  LISYGPCQTPTLGFCVQRHLQITTFKPENFGLYALILCK--TAMNLIWTGNVASYSTVTAMFQKRVIEDGIAEVTEILEKQENKVRPSGLNTVNLLKVAS
        +ISYGPCQTPTLGFCVQR+ QITTFKPE F      + K    + L W         VT MFQK V  DGI +VT+I  K+E K RP GLNTVNLLKVAS
Subjt:  LISYGPCQTPTLGFCVQRHLQITTFKPENFGLYALILCK--TAMNLIWTGNVASYSTVTAMFQKRVIEDGIAEVTEILEKQENKVRPSGLNTVNLLKVAS

Query:  SALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAWRLYQY
        SALG GPQ AM LAERLYTQGFISYPRTESTAYPSSFDF+  L  L  NP W + VR LL  G+ KP+ G D GDHPPITPM LATE+ LG DAWRLYQY
Subjt:  SALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAWRLYQY

Query:  VCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAVNEKKLPQFLKGEKIDVARVDLYQGNTTPPDYLSESELISLMEKHGIGTDA
        +CQHFIG++S DC+Y RT I+F+  GE F+C G+RVT KGFTSIMPWLAV+E  +P + KG+ + + +VD+Y+G+TTPPDYLSESELISLMEK+GIGTDA
Subjt:  VCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAVNEKKLPQFLKGEKIDVARVDLYQGNTTPPDYLSESELISLMEKHGIGTDA

Query:  SIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVVQSVLQQFKQKYSYFVKKIDHMDALFEAQFS
        SIPVH+NNI ERNYVQV +GRRLVPT LG TLIRGYQCID DLCLPDIR FIE QITL+AKG+ADH  VVQ VLQQF +KYSYFVKKI++MDALFEAQFS
Subjt:  SIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVVQSVLQQFKQKYSYFVKKIDHMDALFEAQFS

Query:  PLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKGAIKLYKELTCPLDNFELLIFSLPGPEGKSFPLCPYCYNSPPFEGISTLYGASKTNP
        PLADSGR LSKCGKC RYMK+IS+QP RLYC  CEEVYYLPQ G+IKLYKE+ CPLD FELL+FS+ GP+ KSFPLCP+CYNSPPFEGI  L+GA K + 
Subjt:  PLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKGAIKLYKELTCPLDNFELLIFSLPGPEGKSFPLCPYCYNSPPFEGISTLYGASKTNP

Query:  SSGTSSKGMGMPCFLCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPQGAHRISTTSDKCADCDSTIIEVDFNKKTTPLEDGA
         +G   KG GMPCFLC HPTC+ S+ITQGVCACPEC+GTL+LDPVSAP W+L CN+CNC+V LP  AH+ISTT  KC  C+STIIEVDFNKKTTPL+DGA
Subjt:  SSGTSSKGMGMPCFLCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPQGAHRISTTSDKCADCDSTIIEVDFNKKTTPLEDGA

Query:  TLFVGCILCDEFLHSLLEMKHGKSFFRGRGSRGRGRGRGRGRGRGGRGRNSGKPMDPKMSFRDF
        TL  GCILCDE LHSL+EMKHGKSFF  RG RGRGRGRGRGRG     R S +  DPKMSFRDF
Subjt:  TLFVGCILCDEFLHSLLEMKHGKSFFRGRGSRGRGRGRGRGRGRGGRGRNSGKPMDPKMSFRDF

Q9Z321 DNA topoisomerase 3-beta-1

2.0e-254

51.72

Show/hide

Query:  IIIVAEKPSIALSIASALSHGQMSTRK---GSTEVHEFDGRFLGHHAYYKVTSVIGHIFSIDFPAGFQDWKTTDPLDLF-QASVIKTESNPKAHIRQHLS
        +++VAEKPS+A SIA  LS G MS+ K   G+  VH++ G F G   ++K+TSV GH+ ++DF   +  W   DP +LF QA   K E+NPK ++ + L 
Subjt:  IIIVAEKPSIALSIASALSHGQMSTRK---GSTEVHEFDGRFLGHHAYYKVTSVIGHIFSIDFPAGFQDWKTTDPLDLF-QASVIKTESNPKAHIRQHLS

Query:  REARGCDCLVLWLDCDREGENICFEVIECT----GFGGNGTRKKVYRARFSSVTEKDILKALDNLVQPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQG
         E RGCD +VLWLDCD+EGENICFEV++          NG  K V+RARFSS+T+ DI  A+  L +P+ NEAL+VDARQE+DL++G AFTRFQT +FQG
Subjt:  REARGCDCLVLWLDCDREGENICFEVIECT----GFGGNGTRKKVYRARFSSVTEKDILKALDNLVQPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQG

Query:  KYGNLDSRLISYGPCQTPTLGFCVQRHLQITTFKPENFG-LYALILCKTAMNLI--WTGNVASYSTVTAMFQKRVIEDGIAEVTEILEKQENKVRPSGLN
        KYG+LDS LIS+GPCQTPTLGFCV+RH +I +FKPE +  L A +      +L+  W         +  MF      +  A V     K++ K RP  LN
Subjt:  KYGNLDSRLISYGPCQTPTLGFCVQRHLQITTFKPENFG-LYALILCKTAMNLI--WTGNVASYSTVTAMFQKRVIEDGIAEVTEILEKQENKVRPSGLN

Query:  TVNLLKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMCLATEDMLG
        TV +L+VASSALG GPQ AMQ+AERLYTQG+ISYPRTE+T YP +FD KG+L     +P W D V+ LL++G ++PR G D GDHPPITPM  ATE  LG
Subjt:  TVNLLKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMCLATEDMLG

Query:  RDAWRLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAVN-EKKLPQFLKGEKIDVARVDLYQGNTTPPDYLSESELISL
         DAWRLY+Y+ +HFI ++S DCKY+++ I F I  E F C G  V   GFT IMPW +V  E+ LP   KG+   V  V + +  T+PPDYL+E+ELI+L
Subjt:  RDAWRLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAVN-EKKLPQFLKGEKIDVARVDLYQGNTTPPDYLSESELISL

Query:  MEKHGIGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVVQSVLQQFKQKYSYFVKKIDH
        MEKHGIGTDASIPVHINNI +RNYV V++GRRL PTNLGI L+ GY  ID +L LP IRS +E Q+ L+A+G+AD+  V+   L  FK+K+ YFV  I  
Subjt:  MEKHGIGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVVQSVLQQFKQKYSYFVKKIDH

Query:  MDALFEAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKGAIKLYKELTCPLDNFELLIFSLPGPEGKSFPLCPYCYNSPPFEGIS
        MD L E  FSPLA +G+ LS+CGKC R+MK+I ++P RL+C  C+E Y LPQ G IKLYKEL CPLD+FEL+++S  G  GKS+PLCPYCYN PPF  + 
Subjt:  MDALFEAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKGAIKLYKELTCPLDNFELLIFSLPGPEGKSFPLCPYCYNSPPFEGIS

Query:  TLYGASKTNPSSGTSSKGMGMPCFLCPHPTCRHSLITQGVCACPEC-SGTLVLDPVSAPNWKLNCNKCNCLVFLPQGAHRISTTSDKCADCDSTIIEVDF
                        KGMG  C  C HPTC+HSL   G+  C EC +G LVLDP S P WK+ CN CN +    + AHR+  ++D C  C++ +++VDF
Subjt:  TLYGASKTNPSSGTSSKGMGMPCFLCPHPTCRHSLITQGVCACPEC-SGTLVLDPVSAPNWKLNCNKCNCLVFLPQGAHRISTTSDKCADCDSTIIEVDF

Query:  NKKTTPLEDGATLFVGCILCDEFLHSLLEMKHGKSFF-RGRGSRGRGRGRGRGRGRGGRGRNSGKPMDPKMS
        NK  +PL    T   GCI CD     L+E+KH  S     RG  GR +GRGRGRGR   G+ + +    KMS
Subjt:  NKKTTPLEDGATLFVGCILCDEFLHSLLEMKHGKSFF-RGRGSRGRGRGRGRGRGRGGRGRNSGKPMDPKMS

Arabidopsis top hits

e value

%identity

Alignment

AT2G32000.1 DNA topoisomerase, type IA, core

0.0e+00

74.48

Show/hide

Query:  IRIIIVAEKPSIALSIASALSHGQMSTRKGSTEVHEFDGRFLGHHAYYKVTSVIGHIFSIDFPAGFQDWKTTDPLDLFQASVIKTESNPKAHIRQHLSRE
        +R+++VAEKPSIALSIAS LSHGQMSTR+GSTEVHEFDG F G  A+Y+VTSVIGH+FS+DFP  +Q+W T DP DLF A +IK ESNPKAHI +HLS E
Subjt:  IRIIIVAEKPSIALSIASALSHGQMSTRKGSTEVHEFDGRFLGHHAYYKVTSVIGHIFSIDFPAGFQDWKTTDPLDLFQASVIKTESNPKAHIRQHLSRE

Query:  ARGCDCLVLWLDCDREGENICFEVIECTGFGGNGTRKKVYRARFSSVTEKDILKALDNLVQPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYGNLD
        ARGC  +VLWLDCDREGENICFEVIE TGF    +++KVYRARFSSVTEKDI KA+DNLV+PNR+EALAVDARQEIDLKVGVAF+RFQT++FQGKY NLD
Subjt:  ARGCDCLVLWLDCDREGENICFEVIECTGFGGNGTRKKVYRARFSSVTEKDILKALDNLVQPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYGNLD

Query:  SRLISYGPCQTPTLGFCVQRHLQITTFKPENFGLYALILCKTA--MNLIWTGNVASYSTVTAMFQKRVIEDGIAEVTEILEKQENKVRPSGLNTVNLLKV
         R+ISYGPCQTPTLGFCVQR++ I TFKPE F      + K    + L W            +FQK V+E   A+V ++ EKQE K RP+GLNTVNLLKV
Subjt:  SRLISYGPCQTPTLGFCVQRHLQITTFKPENFGLYALILCKTA--MNLIWTGNVASYSTVTAMFQKRVIEDGIAEVTEILEKQENKVRPSGLNTVNLLKV

Query:  ASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAWRLY
        ASSALGFGPQ AM LAERLYTQGFISYPRTESTAYPSSFDF  TL   V NP WG YV+ LLSDG+  P+SGTD GDHPPITPM  ATE M+G DAWRLY
Subjt:  ASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAWRLY

Query:  QYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAVNEKKLPQFLKGEKIDVARVDLYQGNTTPPDYLSESELISLMEKHGIGT
        QYVCQHF+G++S +CKYIRTK++ SI GE F+CTG RVT KGFT+IMPW AV+EKKLP FLKGE+I+V RV+LY+GNT PPDYL+ESELISLMEKHGIGT
Subjt:  QYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAVNEKKLPQFLKGEKIDVARVDLYQGNTTPPDYLSESELISLMEKHGIGT

Query:  DASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVVQSVLQQFKQKYSYFVKKIDHMDALFEAQ
        DASI VHINNIGERNYVQVQ+GR++VPT LGITLIRGYQCIDPDLCLPDIRSFIE QITLVAKGQADHS VVQ V+QQF++K+SYFV++I+HMDALFEAQ
Subjt:  DASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVVQSVLQQFKQKYSYFVKKIDHMDALFEAQ

Query:  FSPLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKGAIKLYKELTCPLDNFELLIFSLPGPEGKSFPLCPYCYNSPPFEGISTLYGASKT
        FSPLADSGRALSKCGKCLRYMK I++ P RL+CG CEEVYYLPQKG +KLYKELTCPLDNFEL+I+S+PGPEGKSFPLCPYCYNSPPFEGI TL+GASKT
Subjt:  FSPLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKGAIKLYKELTCPLDNFELLIFSLPGPEGKSFPLCPYCYNSPPFEGISTLYGASKT

Query:  NPSSGTSSKGMGMPCFLCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPQGAHRISTTSDKCADCDSTIIEVDFNKKTTPLED
          +   +  G GMPC LCPHPTC+HS+  QGVCACPEC GTLVLDPVS P WKLNCN C+C+V LP+GAHRI+TTS++C +CDS IIE+DFNKKTTPLE+
Subjt:  NPSSGTSSKGMGMPCFLCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFLPQGAHRISTTSDKCADCDSTIIEVDFNKKTTPLED

Query:  GATLFVGCILCDEFLHSLLEMKHGKSFFRGRGSRGRGRGRGRGRGRGGRGRNSGKPMDPKMSFRDF
        GATL  GC+LCDE L SL+E+KHG+SF R RG RGRGRGRGRGRG    GR   K +DPKMSFRDF
Subjt:  GATLFVGCILCDEFLHSLLEMKHGKSFFRGRGSRGRGRGRGRGRGRGGRGRNSGKPMDPKMSFRDF

AT2G32000.2 DNA topoisomerase, type IA, core

0.0e+00

73.83

Show/hide

Query:  HIFSI---DFPAGFQDWKTTDPLDLFQASVIKTESNPKAHIRQHLSREARGCDCLVLWLDCDREGENICFEVIECTGFGGNGTRKKVYRARFSSVTEKDI
        H+ S+   DFP  +Q+W T DP DLF A +IK ESNPKAHI +HLS EARGC  +VLWLDCDREGENICFEVIE TGF    +++KVYRARFSSVTEKDI
Subjt:  HIFSI---DFPAGFQDWKTTDPLDLFQASVIKTESNPKAHIRQHLSREARGCDCLVLWLDCDREGENICFEVIECTGFGGNGTRKKVYRARFSSVTEKDI

Query:  LKALDNLVQPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYGNLDSRLISYGPCQTPTLGFCVQRHLQITTFKPENFGLYALILCKTA--MNLIWTG
         KA+DNLV+PNR+EALAVDARQEIDLKVGVAF+RFQT++FQGKY NLD R+ISYGPCQTPTLGFCVQR++ I TFKPE F      + K    + L W  
Subjt:  LKALDNLVQPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYGNLDSRLISYGPCQTPTLGFCVQRHLQITTFKPENFGLYALILCKTA--MNLIWTG

Query:  NVASYSTVTAMFQKRVIEDGIAEVTEILEKQENKVRPSGLNTVNLLKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNP
                  +FQK V+E   A+V ++ EKQE K RP+GLNTVNLLKVASSALGFGPQ AM LAERLYTQGFISYPRTESTAYPSSFDF  TL   V NP
Subjt:  NVASYSTVTAMFQKRVIEDGIAEVTEILEKQENKVRPSGLNTVNLLKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNP

Query:  EWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAWRLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAV
         WG YV+ LLSDG+  P+SGTD GDHPPITPM  ATE M+G DAWRLYQYVCQHF+G++S +CKYIRTK++ SI GE F+CTG RVT KGFT+IMPW AV
Subjt:  EWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAWRLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAV

Query:  NEKKLPQFLKGEKIDVARVDLYQGNTTPPDYLSESELISLMEKHGIGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRS
        +EKKLP FLKGE+I+V RV+LY+GNT PPDYL+ESELISLMEKHGIGTDASI VHINNIGERNYVQVQ+GR++VPT LGITLIRGYQCIDPDLCLPDIRS
Subjt:  NEKKLPQFLKGEKIDVARVDLYQGNTTPPDYLSESELISLMEKHGIGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRS

Query:  FIEHQITLVAKGQADHSSVVQSVLQQFKQKYSYFVKKIDHMDALFEAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKGAIKLYK
        FIE QITLVAKGQADHS VVQ V+QQF++K+SYFV++I+HMDALFEAQFSPLADSGRALSKCGKCLRYMK I++ P RL+CG CEEVYYLPQKG +KLYK
Subjt:  FIEHQITLVAKGQADHSSVVQSVLQQFKQKYSYFVKKIDHMDALFEAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKGAIKLYK

Query:  ELTCPLDNFELLIFSLPGPEGKSFPLCPYCYNSPPFEGISTLYGASKTNPSSGTSSKGMGMPCFLCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNW
        ELTCPLDNFEL+I+S+PGPEGKSFPLCPYCYNSPPFEGI TL+GASKT  +   +  G GMPC LCPHPTC+HS+  QGVCACPEC GTLVLDPVS P W
Subjt:  ELTCPLDNFELLIFSLPGPEGKSFPLCPYCYNSPPFEGISTLYGASKTNPSSGTSSKGMGMPCFLCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNW

Query:  KLNCNKCNCLVFLPQGAHRISTTSDKCADCDSTIIEVDFNKKTTPLEDGATLFVGCILCDEFLHSLLEMKHGKSFFRGRGSRGRGRGRGRGRGRGGRGRN
        KLNCN C+C+V LP+GAHRI+TTS++C +CDS IIE+DFNKKTTPLE+GATL  GC+LCDE L SL+E+KHG+SF R RG RGRGRGRGRGRG    GR 
Subjt:  KLNCNKCNCLVFLPQGAHRISTTSDKCADCDSTIIEVDFNKKTTPLEDGATLFVGCILCDEFLHSLLEMKHGKSFFRGRGSRGRGRGRGRGRGRGGRGRN

Query:  SGKPMDPKMSFRDF
          K +DPKMSFRDF
Subjt:  SGKPMDPKMSFRDF

AT5G63920.1 topoisomerase 3alpha

1.1e-103

35.4

Show/hide

Query:  IRIIIVAEKPSIALSIASALSHGQMSTRKGST---EVHEFDGRFLGHHAYYKVTSVIGHIFSIDFPAGFQDWKTTDPLDLFQASVIKTESNPKAHIRQHL
        + ++ VAEKPS+A S+A  LS G   TR+G +   ++ EFD    G      +TSVIGH+  ++F   ++ W + DP DL+QA V+K     K  I++ L
Subjt:  IRIIIVAEKPSIALSIASALSHGQMSTRKGST---EVHEFDGRFLGHHAYYKVTSVIGHIFSIDFPAGFQDWKTTDPLDLFQASVIKTESNPKAHIRQHL

Query:  SREARGCDCLVLWLDCDREGENICFEVIE-CTGFGGNGTRKKVYRARFSSVTEKDILKALDNLVQPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKY
          EAR  D LVLWLDCDREGENI FEV++ C     N     + RA FS++ ++DI +A+ NL  PN+  A AVDARQEIDL++G +FTRFQT   + ++
Subjt:  SREARGCDCLVLWLDCDREGENICFEVIE-CTGFGGNGTRKKVYRARFSSVTEKDILKALDNLVQPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKY

Query:  -----GNLDSRLISYGPCQTPTLGFCVQRHLQITTFKPENFGLYALILC-----KTAMNLIW-TGNVASYSTVTAMFQKRVIEDGIAEVTEILEKQEN-K
             G   SR+ISYGPCQ PTLGF V+R+ +I   +PE F     I C     +      W  G++  Y++   +++   +E+  A V  +   +E  K
Subjt:  -----GNLDSRLISYGPCQTPTLGFCVQRHLQITTFKPENFGLYALILC-----KTAMNLIW-TGNVASYSTVTAMFQKRVIEDGIAEVTEILEKQEN-K

Query:  VRPSGLNTVNLLKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSD----GYSKPRSGTDVGDHPPIT
          P  LNT+ L K AS       +  M++AE LY  GFISYPRTE+ ++ S  D +  +    ++P WG Y + LL        +    G D   HPPI 
Subjt:  VRPSGLNTVNLLKVASSALGFGPQMAMQLAERLYTQGFISYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSD----GYSKPRSGTDVGDHPPIT

Query:  PMCLAT-EDMLGRDAWRLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAVNEKKLPQFLKGEKIDVARVDLYQGNTTPP
        P   ++ E    RD   +Y+ V +H++  +S       T ++  IAGE F+ +G  +  K +  +  + +     +P + KG++     + L    T PP
Subjt:  PMCLAT-EDMLGRDAWRLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTGSRVTVKGFTSIMPWLAVNEKKLPQFLKGEKIDVARVDLYQGNTTPP

Query:  DYLSESELISLMEKHGIGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVVQSVLQQFKQ
          L E++L+S M+K GIGTDA++  HI  + +R Y    A  R  PTNLG  L+ GY  +  +L  P++R+ +EH +  V+ G+   + V+++ LQQ K 
Subjt:  DYLSESELISLMEKHGIGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDLCLPDIRSFIEHQITLVAKGQADHSSVVQSVLQQFKQ

Query:  KY-SYFVKK---IDHMDALFE----AQFSPLADSGRALSKCGKC
         +    VKK   ++ M   FE       S    +G  + +C  C
Subjt:  KY-SYFVKK---IDHMDALFE----AQFSPLADSGRALSKCGKC

Sequences

Show/hide sequences

CDS sequence

Show/hide CDS sequence

ATGTTAGAGTTACAAGTTTGTATACGTATAATTATTGTTGCAGAGAAGCCTAGCATTGCGCTTTCAATTGCTTCTGCACTGTCCCATGGCCAAATGTCTACAAGAAAGGG
TAGCACAGAGGTACATGAATTTGACGGGAGATTTCTTGGGCATCATGCTTATTATAAAGTGACATCAGTTATCGGACATATTTTCAGTATAGATTTCCCAGCTGGATTTC
AAGATTGGAAGACCACCGATCCTTTGGATCTTTTTCAAGCTTCAGTAATTAAGACAGAATCAAACCCAAAGGCACACATACGTCAACATTTAAGTCGAGAAGCACGTGGT
TGTGATTGTTTGGTTTTATGGTTGGATTGTGATCGTGAAGGAGAAAATATTTGTTTTGAAGTTATTGAGTGCACTGGATTTGGTGGCAATGGAACGAGGAAAAAAGTGTA
TCGTGCAAGGTTTTCTTCTGTTACTGAGAAAGATATTCTGAAGGCTTTGGATAACCTTGTTCAACCTAATAGAAATGAGGCACTTGCTGTTGATGCTCGACAAGAGATAG
ATTTGAAAGTTGGAGTAGCCTTTACACGATTTCAGACTACCTTTTTTCAGGGAAAATATGGAAACCTCGATTCCAGACTCATTTCCTATGGACCATGCCAAACACCCACG
CTTGGGTTTTGTGTACAGCGTCATTTGCAAATAACCACCTTTAAACCAGAAAATTTTGGTCTGTATGCCCTTATATTATGCAAAACGGCTATGAACTTAATCTGGACTGG
GAACGTGGCAAGTTATTCGACTGTTACTGCAATGTTCCAAAAGCGAGTAATAGAAGATGGAATAGCAGAAGTAACAGAAATATTAGAGAAGCAAGAAAACAAAGTTCGAC
CTTCTGGGCTAAATACAGTTAACCTTCTGAAGGTTGCTTCAAGTGCACTAGGATTTGGACCTCAAATGGCAATGCAACTAGCCGAAAGATTATATACGCAAGGATTCATC
AGCTATCCACGTACAGAAAGTACGGCTTATCCTTCTTCATTTGACTTCAAAGGCACTCTACATACCCTAGTGAAAAATCCAGAATGGGGTGATTATGTACGGATGCTTCT
GTCTGATGGATACAGTAAACCACGATCAGGAACTGACGTGGGTGATCATCCTCCCATTACTCCAATGTGTTTAGCAACAGAAGATATGTTAGGGAGAGATGCTTGGAGAT
TGTACCAATATGTGTGTCAACATTTCATTGGGTCTCTGTCTTCTGACTGCAAGTATATTAGGACGAAGATACAGTTTTCAATCGCTGGAGAAATATTCAATTGTACTGGG
TCACGTGTTACAGTAAAAGGATTCACCTCCATTATGCCATGGTTGGCAGTAAATGAAAAAAAACTACCTCAGTTTCTGAAGGGAGAGAAAATTGATGTTGCAAGAGTGGA
TCTTTATCAGGGTAATACCACGCCTCCGGATTATTTAAGTGAAAGTGAGTTGATTTCTCTCATGGAGAAGCATGGAATAGGCACGGATGCATCAATACCAGTACACATTA
ACAACATAGGCGAGCGCAACTATGTTCAGGTTCAAGCTGGGAGGAGGTTGGTTCCAACTAACTTGGGCATCACCTTAATTAGAGGATATCAATGTATTGATCCAGATCTC
TGTTTACCAGATATTCGAAGTTTCATTGAGCATCAGATCACTCTTGTTGCCAAAGGTCAAGCAGATCATTCTAGTGTTGTGCAGAGTGTATTGCAACAGTTCAAGCAAAA
GTATAGCTACTTCGTTAAGAAGATTGATCATATGGATGCTCTGTTTGAAGCACAATTTTCTCCCCTTGCCGATTCAGGACGTGCTTTGAGCAAATGTGGAAAGTGCCTGC
GGTATATGAAGTTTATTTCTTCCCAACCACAGCGTCTGTACTGTGGTATATGTGAGGAGGTTTATTATCTTCCTCAAAAGGGAGCAATAAAGCTGTATAAGGAACTTACA
TGCCCTCTGGACAACTTCGAGCTCTTGATTTTTTCCTTACCTGGCCCAGAAGGCAAGTCATTTCCTCTTTGCCCATATTGCTACAATAGTCCTCCATTTGAGGGTATCAG
CACATTATATGGTGCTTCTAAAACCAACCCAAGTTCCGGAACATCAAGCAAGGGAATGGGCATGCCATGCTTCCTGTGTCCGCACCCAACATGTCGACATTCTTTAATAA
CCCAAGGAGTTTGCGCTTGCCCGGAATGTAGCGGGACGCTTGTCCTAGATCCTGTGAGTGCACCCAACTGGAAACTCAACTGCAACAAATGCAATTGTCTTGTCTTCCTT
CCTCAAGGTGCTCATAGGATTTCCACCACAAGTGACAAGTGTGCTGATTGTGACTCTACAATTATAGAAGTTGACTTCAACAAGAAAACGACACCATTGGAGGATGGAGC
TACATTGTTTGTTGGATGCATTCTTTGCGATGAGTTTCTCCATTCACTTCTGGAGATGAAACATGGAAAATCATTTTTCAGAGGCAGAGGTTCGAGAGGAAGAGGAAGGG
GAAGAGGAAGAGGACGGGGAAGGGGAGGAAGAGGACGTAATTCAGGGAAACCAATGGACCCAAAAATGAGTTTCCGAGATTTCTGA

mRNA sequence

Show/hide mRNA sequence

Protein sequence

Show/hide protein sequence

MLELQVCIRIIIVAEKPSIALSIASALSHGQMSTRKGSTEVHEFDGRFLGHHAYYKVTSVIGHIFSIDFPAGFQDWKTTDPLDLFQASVIKTESNPKAHIRQHLSREARG
CDCLVLWLDCDREGENICFEVIECTGFGGNGTRKKVYRARFSSVTEKDILKALDNLVQPNRNEALAVDARQEIDLKVGVAFTRFQTTFFQGKYGNLDSRLISYGPCQTPT
LGFCVQRHLQITTFKPENFGLYALILCKTAMNLIWTGNVASYSTVTAMFQKRVIEDGIAEVTEILEKQENKVRPSGLNTVNLLKVASSALGFGPQMAMQLAERLYTQGFI
SYPRTESTAYPSSFDFKGTLHTLVKNPEWGDYVRMLLSDGYSKPRSGTDVGDHPPITPMCLATEDMLGRDAWRLYQYVCQHFIGSLSSDCKYIRTKIQFSIAGEIFNCTG
SRVTVKGFTSIMPWLAVNEKKLPQFLKGEKIDVARVDLYQGNTTPPDYLSESELISLMEKHGIGTDASIPVHINNIGERNYVQVQAGRRLVPTNLGITLIRGYQCIDPDL
CLPDIRSFIEHQITLVAKGQADHSSVVQSVLQQFKQKYSYFVKKIDHMDALFEAQFSPLADSGRALSKCGKCLRYMKFISSQPQRLYCGICEEVYYLPQKGAIKLYKELT
CPLDNFELLIFSLPGPEGKSFPLCPYCYNSPPFEGISTLYGASKTNPSSGTSSKGMGMPCFLCPHPTCRHSLITQGVCACPECSGTLVLDPVSAPNWKLNCNKCNCLVFL
PQGAHRISTTSDKCADCDSTIIEVDFNKKTTPLEDGATLFVGCILCDEFLHSLLEMKHGKSFFRGRGSRGRGRGRGRGRGRGGRGRNSGKPMDPKMSFRDF

PI0022127 (gene) of Melon (PI 482460) v1 genome