; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; CuGenDBv2

PI0027222 (gene) of Melon (PI 482460) v1 genome

Gene IDPI0027222
OrganismCucumis metuliferus PI 482460 (Melon (PI 482460) v1)
Descriptionprotein GLUTAMINE DUMPER 3-like
Genome locationchr03:4756143..4756949
RNA-Seq ExpressionPI0027222
SyntenyPI0027222
Gene Ontology termsGO:0080143 - regulation of amino acid export (biological process)
GO:0016021 - integral component of membrane (cellular component)
GO:0000166 - nucleotide binding (molecular function)
InterPro domainsIPR040359 - Protein glutamine dumper


Homology Show/hide homology
GenBank top hitse value%identityAlignment
KAA0064868.1 protein GLUTAMINE DUMPER 3-like [Cucumis melo var. makuwa]3.4e-7590.8Show/hide
Query:  MRKIISASSPINSPEPPAVSQRTPWHSPVPYLFGGLAAMLGLIAFALLILACSYWKLSIQSEEREGENRDLESGNN-GEMEEEKIKQQQTKTIFEEKILV
        MR IISASSP+ SPEPPAVS RTPWHSPVPYLFGGLAAMLGLIAFALLILACSYWKLSIQ+EEREGEN DLESGNN GEMEEEKIKQQQTK IFEEKILV
Subjt:  MRKIISASSPINSPEPPAVSQRTPWHSPVPYLFGGLAAMLGLIAFALLILACSYWKLSIQSEEREGENRDLESGNN-GEMEEEKIKQQQTKTIFEEKILV

Query:  IMAGDQNPTFLATPVTTPKFSSISQNSKNVCSGKFDKFVEKNEMGCNCEKSKEMGHHQNQE--QQHQEQQEEAE
        IMAGDQNPTFLATPVTTPK SSISQNSKNVCSGKFD FVEKNE+GCNCEKSKEMGHHQNQE  QQHQEQQ+  E
Subjt:  IMAGDQNPTFLATPVTTPKFSSISQNSKNVCSGKFDKFVEKNEMGCNCEKSKEMGHHQNQE--QQHQEQQEEAE

KAE8652215.1 hypothetical protein Csa_021923 [Cucumis sativus]9.0e-6083.67Show/hide
Query:  MRKIISASSPINSPEPPAVSQRTPWHSPVPYLFGGLAAMLGLIAFALLILACSYWKLSIQSEEREGENRDLESGNNGEMEEEKIKQQQTKTIFEEKILVI
        MR I+SA+SPIN+PEPPA SQRTPWHSPVPYLFGGLAAMLGLIAFALLILACSYWKLSIQSEER+G+NRDLES N GE+EEEKIKQ QT  IFEEKILVI
Subjt:  MRKIISASSPINSPEPPAVSQRTPWHSPVPYLFGGLAAMLGLIAFALLILACSYWKLSIQSEEREGENRDLESGNNGEMEEEKIKQQQTKTIFEEKILVI

Query:  MAGDQNPTFLATPVTTPKFSSISQNSKNVCSGKFDKFVEKN-EMGCN
        MAGDQNPTFLATPVTTP+FSS+SQNS N+ S  FD FV+KN EMGC+
Subjt:  MAGDQNPTFLATPVTTPKFSSISQNSKNVCSGKFDKFVEKN-EMGCN

XP_008445290.1 PREDICTED: protein GLUTAMINE DUMPER 3-like [Cucumis melo]3.4e-7590.8Show/hide
Query:  MRKIISASSPINSPEPPAVSQRTPWHSPVPYLFGGLAAMLGLIAFALLILACSYWKLSIQSEEREGENRDLESGNN-GEMEEEKIKQQQTKTIFEEKILV
        MR IISASSP+ SPEPPAVS RTPWHSPVPYLFGGLAAMLGLIAFALLILACSYWKLSIQ+EEREGEN DLESGNN GEMEEEKIKQQQTK IFEEKILV
Subjt:  MRKIISASSPINSPEPPAVSQRTPWHSPVPYLFGGLAAMLGLIAFALLILACSYWKLSIQSEEREGENRDLESGNN-GEMEEEKIKQQQTKTIFEEKILV

Query:  IMAGDQNPTFLATPVTTPKFSSISQNSKNVCSGKFDKFVEKNEMGCNCEKSKEMGHHQNQEQ--QHQEQQEEAE
        IMAGDQNPTFLATPVTTPK SSISQNSKNVCSGKFD FVEKNE+GCNCEKSKEMGHHQNQEQ  QHQEQQ+  E
Subjt:  IMAGDQNPTFLATPVTTPKFSSISQNSKNVCSGKFDKFVEKNEMGCNCEKSKEMGHHQNQEQ--QHQEQQEEAE

XP_011649855.1 protein GLUTAMINE DUMPER 2 [Cucumis sativus]1.1e-6882.12Show/hide
Query:  MRKIISASSPINSPEPPAVSQRTPWHSPVPYLFGGLAAMLGLIAFALLILACSYWKLSIQSEEREGENRDLESGNNGEMEEEKIKQQQTKTIFEEKILVI
        MR I+SA+SPIN+PEPPA SQRTPWHSPVPYLFGGLAAMLGLIAFALLILACSYWKLSIQSEER+G+NRDLES N GE+EEEKIKQ QT  IFEEKILVI
Subjt:  MRKIISASSPINSPEPPAVSQRTPWHSPVPYLFGGLAAMLGLIAFALLILACSYWKLSIQSEEREGENRDLESGNNGEMEEEKIKQQQTKTIFEEKILVI

Query:  MAGDQNPTFLATPVTTPKFSSISQNSKNVCSGKFDKFVEKN-EMGC-NCEKSKEMGHHQNQEQQHQE------QQEEAE
        MAGDQNPTFLATPVTTP+FSS+SQNS N+ S  FD FV+KN EMGC NCEK+KEMGHHQNQEQQHQE      QQ+EAE
Subjt:  MAGDQNPTFLATPVTTPKFSSISQNSKNVCSGKFDKFVEKN-EMGC-NCEKSKEMGHHQNQEQQHQE------QQEEAE

XP_038885711.1 protein GLUTAMINE DUMPER 2-like [Benincasa hispida]5.5e-5773.68Show/hide
Query:  MRKIISASSPINSPEPPAVSQRTPWHSPVPYLFGGLAAMLGLIAFALLILACSYWKLSIQSEEREGENRDLESGNNGEMEEEKIKQQQTKTIFEEKILVI
        MR +ISA SPINSPEP AVSQRTPWHSPVPYLFGGLAAMLGLIAFALLILACSYWKLS+QS+EREG+ RDLESG + + E+EKIK+QQTK ++EEKILVI
Subjt:  MRKIISASSPINSPEPPAVSQRTPWHSPVPYLFGGLAAMLGLIAFALLILACSYWKLSIQSEEREGENRDLESGNNGEMEEEKIKQQQTKTIFEEKILVI

Query:  MAGDQNPTFLATPVTTPKFSSISQNSKNVCSGKFDKFVEKNEMGCNCEKSKEMGHHQNQEQQHQEQQEEAE
        MAGDQNPTFLATPVTTPK SSISQ   NV +GK    VE N M  N +K+KEMGH Q ++ +H+E++EEA+
Subjt:  MAGDQNPTFLATPVTTPKFSSISQNSKNVCSGKFDKFVEKNEMGCNCEKSKEMGHHQNQEQQHQEQQEEAE

TrEMBL top hitse value%identityAlignment
A0A0A0LQG9 Uncharacterized protein5.2e-6982.12Show/hide
Query:  MRKIISASSPINSPEPPAVSQRTPWHSPVPYLFGGLAAMLGLIAFALLILACSYWKLSIQSEEREGENRDLESGNNGEMEEEKIKQQQTKTIFEEKILVI
        MR I+SA+SPIN+PEPPA SQRTPWHSPVPYLFGGLAAMLGLIAFALLILACSYWKLSIQSEER+G+NRDLES N GE+EEEKIKQ QT  IFEEKILVI
Subjt:  MRKIISASSPINSPEPPAVSQRTPWHSPVPYLFGGLAAMLGLIAFALLILACSYWKLSIQSEEREGENRDLESGNNGEMEEEKIKQQQTKTIFEEKILVI

Query:  MAGDQNPTFLATPVTTPKFSSISQNSKNVCSGKFDKFVEKN-EMGC-NCEKSKEMGHHQNQEQQHQE------QQEEAE
        MAGDQNPTFLATPVTTP+FSS+SQNS N+ S  FD FV+KN EMGC NCEK+KEMGHHQNQEQQHQE      QQ+EAE
Subjt:  MAGDQNPTFLATPVTTPKFSSISQNSKNVCSGKFDKFVEKN-EMGC-NCEKSKEMGHHQNQEQQHQE------QQEEAE

A0A1S3BCB1 protein GLUTAMINE DUMPER 3-like1.7e-7590.8Show/hide
Query:  MRKIISASSPINSPEPPAVSQRTPWHSPVPYLFGGLAAMLGLIAFALLILACSYWKLSIQSEEREGENRDLESGNN-GEMEEEKIKQQQTKTIFEEKILV
        MR IISASSP+ SPEPPAVS RTPWHSPVPYLFGGLAAMLGLIAFALLILACSYWKLSIQ+EEREGEN DLESGNN GEMEEEKIKQQQTK IFEEKILV
Subjt:  MRKIISASSPINSPEPPAVSQRTPWHSPVPYLFGGLAAMLGLIAFALLILACSYWKLSIQSEEREGENRDLESGNN-GEMEEEKIKQQQTKTIFEEKILV

Query:  IMAGDQNPTFLATPVTTPKFSSISQNSKNVCSGKFDKFVEKNEMGCNCEKSKEMGHHQNQEQ--QHQEQQEEAE
        IMAGDQNPTFLATPVTTPK SSISQNSKNVCSGKFD FVEKNE+GCNCEKSKEMGHHQNQEQ  QHQEQQ+  E
Subjt:  IMAGDQNPTFLATPVTTPKFSSISQNSKNVCSGKFDKFVEKNEMGCNCEKSKEMGHHQNQEQ--QHQEQQEEAE

A0A5A7VB83 Protein GLUTAMINE DUMPER 3-like1.7e-7590.8Show/hide
Query:  MRKIISASSPINSPEPPAVSQRTPWHSPVPYLFGGLAAMLGLIAFALLILACSYWKLSIQSEEREGENRDLESGNN-GEMEEEKIKQQQTKTIFEEKILV
        MR IISASSP+ SPEPPAVS RTPWHSPVPYLFGGLAAMLGLIAFALLILACSYWKLSIQ+EEREGEN DLESGNN GEMEEEKIKQQQTK IFEEKILV
Subjt:  MRKIISASSPINSPEPPAVSQRTPWHSPVPYLFGGLAAMLGLIAFALLILACSYWKLSIQSEEREGENRDLESGNN-GEMEEEKIKQQQTKTIFEEKILV

Query:  IMAGDQNPTFLATPVTTPKFSSISQNSKNVCSGKFDKFVEKNEMGCNCEKSKEMGHHQNQE--QQHQEQQEEAE
        IMAGDQNPTFLATPVTTPK SSISQNSKNVCSGKFD FVEKNE+GCNCEKSKEMGHHQNQE  QQHQEQQ+  E
Subjt:  IMAGDQNPTFLATPVTTPKFSSISQNSKNVCSGKFDKFVEKNEMGCNCEKSKEMGHHQNQE--QQHQEQQEEAE

A0A6J1HEE9 protein GLUTAMINE DUMPER 5-like2.3e-3764.6Show/hide
Query:  ISASSPINSPEPPAVSQRTPWHSPVPYLFGGLAAMLGLIAFALLILACSYWKLSIQSEEREGENRDLESG----NNGEMEEEKIKQQQTKTIFEEKILVI
        IS SSP++SP    VSQR PWHSPVPYLFGGLAAMLGLIAFALLILACSYWKL++QSEE     RDLESG    NN E EEEKIK+++ K ++EEKILVI
Subjt:  ISASSPINSPEPPAVSQRTPWHSPVPYLFGGLAAMLGLIAFALLILACSYWKLSIQSEEREGENRDLESG----NNGEMEEEKIKQQQTKTIFEEKILVI

Query:  MAGDQNPTFLATPVTTPKFSSISQNSKNVCSGKFDKFVEKNEMGCNCEKSKEMGHHQNQEQ
        MAGD+NP+FLATPV TPK SS S +S N  SGK      ++    NCEK KEMG  +  E+
Subjt:  MAGDQNPTFLATPVTTPKFSSISQNSKNVCSGKFDKFVEKNEMGCNCEKSKEMGHHQNQEQ

A0A6J1KDK1 protein GLUTAMINE DUMPER 5-like8.0e-3863.8Show/hide
Query:  KIISASSPINSPEPPAVSQRTPWHSPVPYLFGGLAAMLGLIAFALLILACSYWKLSIQSEEREGENRDLESG----NNGEMEEEKIKQQQTKTIFEEKIL
        + IS SSP+ S +P AVSQR PWHSPVPYLFGGLAAMLGLIAFALLILACSYWKL++QSEE     RDLESG    NN E EEEKIK+++ K ++EEKIL
Subjt:  KIISASSPINSPEPPAVSQRTPWHSPVPYLFGGLAAMLGLIAFALLILACSYWKLSIQSEEREGENRDLESG----NNGEMEEEKIKQQQTKTIFEEKIL

Query:  VIMAGDQNPTFLATPVTTPKFSSISQNSKNVCSGKFDKFVEKNEMGCNCEKSKEMGHHQNQEQ
        VIMAGD+NP+FLATPV TPK SS S +S N  SGK            N EK KEMG  +  E+
Subjt:  VIMAGDQNPTFLATPVTTPKFSSISQNSKNVCSGKFDKFVEKNEMGCNCEKSKEMGHHQNQEQ

SwissProt top hitse value%identityAlignment
O81775 Protein GLUTAMINE DUMPER 12.5e-2048.12Show/hide
Query:  VSQRTPWHSPVPYLFGGLAAMLGLIAFALLILACSYWKLSIQSEEREGENRDLESGNNGEMEEEKIKQQQTKTIFEEKILVIMAGDQNPTFLATPVTTPK
        V+ ++PWHSPVPYLFGGLAAMLGLIAFALLILACSYW+LS   EE +G+N D       E +E +   +     +EEK LVIMAG+  P +LATP     
Subjt:  VSQRTPWHSPVPYLFGGLAAMLGLIAFALLILACSYWKLSIQSEEREGENRDLESGNNGEMEEEKIKQQQTKTIFEEKILVIMAGDQNPTFLATPVTTPK

Query:  FSSISQNSKNVCSGKFDKFVEKNEMGCNCEKSK
                K  C G   K V   E     E+ K
Subjt:  FSSISQNSKNVCSGKFDKFVEKNEMGCNCEKSK

Q3E965 Protein GLUTAMINE DUMPER 53.5e-2264.52Show/hide
Query:  RTPWHSPVPYLFGGLAAMLGLIAFALLILACSYWKLSIQSEEREGENRDLESGNNGEMEEEKIKQQQTKTIFEEKILVIMAGDQNPTFLATPV
        R+PW +PVPYLFGGLAAMLGLIAFALL+LACSYW+LS Q+E+   E +  ESG       EK+        FEEKILVIMAG  NPTFLATPV
Subjt:  RTPWHSPVPYLFGGLAAMLGLIAFALLILACSYWKLSIQSEEREGENRDLESGNNGEMEEEKIKQQQTKTIFEEKILVIMAGDQNPTFLATPV

Q8S8A0 Protein GLUTAMINE DUMPER 42.1e-1960.44Show/hide
Query:  TPWHSPVPYLFGGLAAMLGLIAFALLILACSYWKLSIQSEEREGENRDLESGNNGEMEEEKIKQQQTKTIFEEKILVIMAGDQNPTFLATP
        +PWHSPVPYLFGGLAAMLGLIAFALLILACSYW+LS   ++  GE  D       E +E +   +      EEK+LVIMAGD  P FLATP
Subjt:  TPWHSPVPYLFGGLAAMLGLIAFALLILACSYWKLSIQSEEREGENRDLESGNNGEMEEEKIKQQQTKTIFEEKILVIMAGDQNPTFLATP

Q9FHH5 Protein GLUTAMINE DUMPER 34.3e-2060.22Show/hide
Query:  TPWHSPVPYLFGGLAAMLGLIAFALLILACSYWKLS--IQSEEREGENRDLESGNNGEMEEEKIKQQQTKTIFEEKILVIMAGDQNPTFLATP
        +PWHSPVPYLFGGLAAMLGLIAFALLILACSYW+LS  +  EE +   RDLE G     + +  K         EK LVIMAG+  PT+LATP
Subjt:  TPWHSPVPYLFGGLAAMLGLIAFALLILACSYWKLS--IQSEEREGENRDLESGNNGEMEEEKIKQQQTKTIFEEKILVIMAGDQNPTFLATP

Q9SW07 Protein GLUTAMINE DUMPER 23.3e-2057.73Show/hide
Query:  VSQRTPWHSPVPYLFGGLAAMLGLIAFALLILACSYWKLSIQSEEREGENRDLESGNNGEMEEEKIKQQQTKTIFEEKILVIMAGDQNPTFLATPVT
        V   +PWHSPVPYLFGGLAAML LI  ALLILACSYW+LS  +E      RDLE+G++ + + +  K + T+    EK LVIMAGD  PT+LATP T
Subjt:  VSQRTPWHSPVPYLFGGLAAMLGLIAFALLILACSYWKLSIQSEEREGENRDLESGNNGEMEEEKIKQQQTKTIFEEKILVIMAGDQNPTFLATPVT

Arabidopsis top hitse value%identityAlignment
AT2G24762.1 glutamine dumper 41.5e-2060.44Show/hide
Query:  TPWHSPVPYLFGGLAAMLGLIAFALLILACSYWKLSIQSEEREGENRDLESGNNGEMEEEKIKQQQTKTIFEEKILVIMAGDQNPTFLATP
        +PWHSPVPYLFGGLAAMLGLIAFALLILACSYW+LS   ++  GE  D       E +E +   +      EEK+LVIMAGD  P FLATP
Subjt:  TPWHSPVPYLFGGLAAMLGLIAFALLILACSYWKLSIQSEEREGENRDLESGNNGEMEEEKIKQQQTKTIFEEKILVIMAGDQNPTFLATP

AT4G25760.1 glutamine dumper 22.3e-2157.73Show/hide
Query:  VSQRTPWHSPVPYLFGGLAAMLGLIAFALLILACSYWKLSIQSEEREGENRDLESGNNGEMEEEKIKQQQTKTIFEEKILVIMAGDQNPTFLATPVT
        V   +PWHSPVPYLFGGLAAML LI  ALLILACSYW+LS  +E      RDLE+G++ + + +  K + T+    EK LVIMAGD  PT+LATP T
Subjt:  VSQRTPWHSPVPYLFGGLAAMLGLIAFALLILACSYWKLSIQSEEREGENRDLESGNNGEMEEEKIKQQQTKTIFEEKILVIMAGDQNPTFLATPVT

AT4G31730.1 glutamine dumper 11.8e-2148.12Show/hide
Query:  VSQRTPWHSPVPYLFGGLAAMLGLIAFALLILACSYWKLSIQSEEREGENRDLESGNNGEMEEEKIKQQQTKTIFEEKILVIMAGDQNPTFLATPVTTPK
        V+ ++PWHSPVPYLFGGLAAMLGLIAFALLILACSYW+LS   EE +G+N D       E +E +   +     +EEK LVIMAG+  P +LATP     
Subjt:  VSQRTPWHSPVPYLFGGLAAMLGLIAFALLILACSYWKLSIQSEEREGENRDLESGNNGEMEEEKIKQQQTKTIFEEKILVIMAGDQNPTFLATPVTTPK

Query:  FSSISQNSKNVCSGKFDKFVEKNEMGCNCEKSK
                K  C G   K V   E     E+ K
Subjt:  FSSISQNSKNVCSGKFDKFVEKNEMGCNCEKSK

AT5G24920.1 glutamine dumper 52.5e-2364.52Show/hide
Query:  RTPWHSPVPYLFGGLAAMLGLIAFALLILACSYWKLSIQSEEREGENRDLESGNNGEMEEEKIKQQQTKTIFEEKILVIMAGDQNPTFLATPV
        R+PW +PVPYLFGGLAAMLGLIAFALL+LACSYW+LS Q+E+   E +  ESG       EK+        FEEKILVIMAG  NPTFLATPV
Subjt:  RTPWHSPVPYLFGGLAAMLGLIAFALLILACSYWKLSIQSEEREGENRDLESGNNGEMEEEKIKQQQTKTIFEEKILVIMAGDQNPTFLATPV

AT5G57685.1 glutamine dumper 33.0e-2160.22Show/hide
Query:  TPWHSPVPYLFGGLAAMLGLIAFALLILACSYWKLS--IQSEEREGENRDLESGNNGEMEEEKIKQQQTKTIFEEKILVIMAGDQNPTFLATP
        +PWHSPVPYLFGGLAAMLGLIAFALLILACSYW+LS  +  EE +   RDLE G     + +  K         EK LVIMAG+  PT+LATP
Subjt:  TPWHSPVPYLFGGLAAMLGLIAFALLILACSYWKLS--IQSEEREGENRDLESGNNGEMEEEKIKQQQTKTIFEEKILVIMAGDQNPTFLATP


Sequences Show/hide sequences
CDS sequenceShow/hide CDS sequence
ATGAGAAAAATAATCTCAGCCTCATCGCCGATAAATTCACCGGAGCCGCCAGCAGTATCACAGCGGACGCCGTGGCACTCGCCGGTGCCGTACTTGTTCGGGGGACTGGC
AGCGATGCTGGGTCTAATCGCGTTCGCGCTCCTCATTCTGGCTTGCTCCTACTGGAAGCTGTCGATCCAATCGGAAGAAAGAGAGGGAGAGAACAGAGATTTAGAGAGCG
GAAACAATGGGGAAATGGAGGAAGAGAAAATTAAGCAACAACAAACGAAGACGATTTTTGAAGAGAAGATTTTGGTGATTATGGCTGGAGACCAAAATCCCACTTTCTTG
GCCACGCCGGTGACCACTCCAAAATTCTCTTCCATTTCCCAAAACTCTAAGAATGTTTGTTCGGGTAAGTTTGATAAATTTGTTGAAAAAAATGAGATGGGTTGTAATTG
TGAGAAAAGTAAAGAAATGGGTCACCATCAAAATCAAGAACAACAACATCAAGAACAACAAGAAGAAGCTGAGTGA
mRNA sequenceShow/hide mRNA sequence
CTCAAACAAACATAAAAAAAAAAAAAGGAAAAAAAAGTAATATTCATCCAAAAAAAGTTTCTACGTTAAATTCCAGACGATATGAGAAAAATAATCTCAGCCTCATCGCC
GATAAATTCACCGGAGCCGCCAGCAGTATCACAGCGGACGCCGTGGCACTCGCCGGTGCCGTACTTGTTCGGGGGACTGGCAGCGATGCTGGGTCTAATCGCGTTCGCGC
TCCTCATTCTGGCTTGCTCCTACTGGAAGCTGTCGATCCAATCGGAAGAAAGAGAGGGAGAGAACAGAGATTTAGAGAGCGGAAACAATGGGGAAATGGAGGAAGAGAAA
ATTAAGCAACAACAAACGAAGACGATTTTTGAAGAGAAGATTTTGGTGATTATGGCTGGAGACCAAAATCCCACTTTCTTGGCCACGCCGGTGACCACTCCAAAATTCTC
TTCCATTTCCCAAAACTCTAAGAATGTTTGTTCGGGTAAGTTTGATAAATTTGTTGAAAAAAATGAGATGGGTTGTAATTGTGAGAAAAGTAAAGAAATGGGTCACCATC
AAAATCAAGAACAACAACATCAAGAACAACAAGAAGAAGCTGAGTGAAGCTTTACTAAAAATCCTCTTTTTTGTTTTTTTGTTTTTTTGTTTTTTGGTTGTTTTTATTAA
ACCAAATTTTACAATTTTGGATATGGATGGATGTTTCTATGTAATTTTGTTTTTGATGTAACGAGAAATGTAAATTAAAATTTTGGAGAGATAAAATGGAGAGTTATGAG
ATAATAATAATATTTGCGATTAAGTTTTGTTTAAAAA
Protein sequenceShow/hide protein sequence
MRKIISASSPINSPEPPAVSQRTPWHSPVPYLFGGLAAMLGLIAFALLILACSYWKLSIQSEEREGENRDLESGNNGEMEEEKIKQQQTKTIFEEKILVIMAGDQNPTFL
ATPVTTPKFSSISQNSKNVCSGKFDKFVEKNEMGCNCEKSKEMGHHQNQEQQHQEQQEEAE