CuGenDBv2

Gene ID	Sed0008745
Organism	Sechium edule (Chayote v1)
Description	DNA topoisomerase 2
Genome location	LG04:38167913..38175198
RNA-Seq Expression	Sed0008745
Synteny	Sed0008745
Gene Ontology terms	GO:0006265 - DNA topological change (biological process) GO:0043231 - intracellular membrane-bounded organelle (cellular component) GO:0003677 - DNA binding (molecular function) GO:0046872 - metal ion binding (molecular function) GO:0005524 - ATP binding (molecular function) GO:0003918 - DNA topoisomerase type II (ATP-hydrolyzing) activity (molecular function)
InterPro domains	IPR013506 - DNA topoisomerase, type IIA, subunit B, domain 2 IPR036890 - Histidine kinase/HSP90-like ATPase superfamily IPR034157 - DNA topoisomerase 2, TOPRIM domain IPR031660 - C-terminal associated domain of TOPRIM IPR020568 - Ribosomal protein S5 domain 2-type fold IPR018522 - DNA topoisomerase, type IIA, conserved site IPR014721 - Ribosomal protein S5 domain 2-type fold, subgroup IPR013760 - DNA topoisomerase, type IIA-like domain superfamily IPR013759 - DNA topoisomerase, type IIA, subunit B, C-terminal IPR013758 - DNA topoisomerase, type IIA, subunit A/ C-terminal, alpha-beta IPR013757 - Type IIA DNA topoisomerase subunit A, alpha-helical domain superfamily IPR006171 - TOPRIM domain IPR003594 - Histidine kinase/HSP90-like ATPase IPR002205 - DNA topoisomerase, type IIA, subunit A/C-terminal IPR001241 - DNA topoisomerase, type IIA IPR001154 - DNA topoisomerase II, eukaryotic-type

Homology

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GenBank top hits

e value

%identity

Alignment

KAG7018075.1 DNA topoisomerase 2 [Cucurbita argyrosperma subsp. argyrosperma]

0.0e+00

88.45

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Query:  MVVEKKRPLQNSTAANVDQIPAGPKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYETDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMD
        M VEKKRPLQNS AANVD  PAGPKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYE DKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMD
Subjt:  MVVEKKRPLQNSTAANVDQIPAGPKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYETDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMD

Query:  SLKVVIDAEQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDDEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRQKKYKQVFSDNMGKKGE
        SLKVVIDAEQN ISVFNNGDGVPVE+HQEEKVYVPELIFGHLLTSSNYDD EKKTTGGRNGYGAKLTNIFSTEFVIETADG+R KKYKQVFSDNMGKK E
Subjt:  SLKVVIDAEQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDDEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRQKKYKQVFSDNMGKKGE

Query:  PIITKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASPSTTDPPKRYHVKPNERWEIMV
        PIITKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVD YLKSA+   T+PPKRYH++PNERWEI+V
Subjt:  PIITKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASPSTTDPPKRYHVKPNERWEIMV

Query:  TLSEGQFQQVSFVNGIATIKGGTHVDYITNQIANYVMNVVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSSFGSACELTPDFLKNV
        TLSEGQFQQVSFVNGIATIKGGTHVDYITNQIANYVM VVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSSFGSACELTPDFLKNV
Subjt:  TLSEGQFQQVSFVNGIATIKGGTHVDYITNQIANYVMNVVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSSFGSACELTPDFLKNV

Query:  AAKSGIMDSVLSWVNFKQSKDMKKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQIT
        A KSGIMDSVLSWVNFKQSKD+KKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQIT
Subjt:  AAKSGIMDSVLSWVNFKQSKDMKKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQIT

Query:  ENKEIQYIKQILGLQQGKEYSNSKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWKESLR
        ENKEIQYIKQILGLQQGKEY+N+KALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLL+VPSFLVEFITPIVKATHRNGTVLSFYTMPEYE+WK++LR
Subjt:  ENKEIQYIKQILGLQQGKEYSNSKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWKESLR

Query:  GNANGWSIKYYKGLGTSTSKEGREYFEQLTRHKKDFIWQDDHDGEAIELAFSKKKIEERKNWLRHFEPGTHLDQTGKLIKYSDFVNKELILFSMADNLRS
        GNA+GWSIKYYKGLGTSTSKEGREYFEQL +HKKDFIWQD+HDGEAIELAFSKKKIEERKNWLR FE GTHLDQ+ KLIKYSDFVNKELILFSMAD  RS
Subjt:  GNANGWSIKYYKGLGTSTSKEGREYFEQLTRHKKDFIWQDDHDGEAIELAFSKKKIEERKNWLRHFEPGTHLDQTGKLIKYSDFVNKELILFSMADNLRS

Query:  IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLAGTIIGMAQDFVGSNNLNLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT
        IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLA TIIGMAQDFVGSNN+NLLLPNGQFGTRNHGGKDHASSRYIYTKLSN T
Subjt:  IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLAGTIIGMAQDFVGSNNLNLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT

Query:  RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGGEGIGTGWSTNIPNYNPRDIIRNVRRMLNDETMLPMDPWYRGFSGIIEKTATKDGCSSYTVS
        RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNG EGIGTGWS+ IPNYNPRDIIRNVRRMLN E MLPMDPWYRGFSG IEKTATK+G +SYTVS
Subjt:  RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGGEGIGTGWSTNIPNYNPRDIIRNVRRMLNDETMLPMDPWYRGFSGIIEKTATKDGCSSYTVS

Query:  GIVEEVSDTTLRITELPVRKWTNDYKEFLDSVTRTS-KNDKDKEK-AKDPFIEQADHHSDDKSVSIDVHLTDENMILAMQEGLKKKLKLTTTINTSNMHL
        GI+EEVSDTTLRITELPVR+WTNDYK+FLDSVTR S KNDKDKEK AKDPFIEQADHHSDDK+VSIDVHLT+ENMILAMQEGLKKK KLTTT++TSNMHL
Subjt:  GIVEEVSDTTLRITELPVRKWTNDYKEFLDSVTRTS-KNDKDKEK-AKDPFIEQADHHSDDKSVSIDVHLTDENMILAMQEGLKKKLKLTTTINTSNMHL

Query:  FDANGMIKKYDTPEQILEEFFPLRLEYYEKRKRVLLENLEMELLKLENKARFILAVVNGEIIVSNRRRVDLVHELQAKGFTPFPKKTKSAEPEIAGASDE
        FDANG+IKKYDTPEQILEEFFPLRLE++EKRKR LLENLE ELLKLENK RFILAVVNGEIIVSNRRRVDL HELQ KGFTPFPKKTKS EPE+AGAS+E
Subjt:  FDANGMIKKYDTPEQILEEFFPLRLEYYEKRKRVLLENLEMELLKLENKARFILAVVNGEIIVSNRRRVDLVHELQAKGFTPFPKKTKSAEPEIAGASDE

Query:  TDQTEESPE-VKGDRVSDYEYLLALAIGTLTIEKVQELCNDRDKLKGEVEDLRKATPKSLWLNDLDSLEKELDEMDRNDAHVDEVRKQQRIANNDVKPKI
        TD+ EESPE VKG+RVSDYEYLLALAIGTLTIEKVQELCN+RDK KGEVE+LRKATPKSLWL DLD LEKELDEMDRNDA  DEVRKQQRI NND+KPKI
Subjt:  TDQTEESPE-VKGDRVSDYEYLLALAIGTLTIEKVQELCNDRDKLKGEVEDLRKATPKSLWLNDLDSLEKELDEMDRNDAHVDEVRKQQRIANNDVKPKI

Query:  TRNAPKAPRNSKKTSHSETAVESSMDTTSSSTTMEVESNAVVKPKGKAAAPRKAPAKKGKSAVVKDDAEDDDDEMLELKDRFAAYRIDSSPDRSEVSAME
        +RNAPKAPRNSKKTS+SET  ES   TTSSSTT EV +N VVKPKGK AAPRKAPAKK   A V DD  DDDDE+LELKDR AAY+++SSP+ SEVSAME
Subjt:  TRNAPKAPRNSKKTSHSETAVESSMDTTSSSTTMEVESNAVVKPKGKAAAPRKAPAKKGKSAVVKDDAEDDDDEMLELKDRFAAYRIDSSPDRSEVSAME

Query:  TEAPQVQ-AGKKKEPTKRAPAKKKTTAKSAQIS-DTDDEEFELKETGPPAGKKGGGGRKAAANAKTTKPPAPTKKREPAAKVGQKLITKMLVPAENSGIS
        TE P+VQ A KKKEP+KRA AKKKTTAKSAQIS D+DD +FE+KE  PPA KK GGGRKAAANAKTTK    TKK+EP A++GQKLIT+ML P ENSGIS
Subjt:  TEAPQVQ-AGKKKEPTKRAPAKKKTTAKSAQIS-DTDDEEFELKETGPPAGKKGGGGRKAAANAKTTKPPAPTKKREPAAKVGQKLITKMLVPAENSGIS

Query:  PEKKVRKIRASPSNKKSASILGMAGIEEEEEEDDDNNSDEEGKIMGGGGSASSDTTEESAGFVP-ARGRSQRTNRTQVKYVHSDSDSEPVAEDSDFDDKD
        PEKKVRKIR SP NKKS S+LG    EEEEE ++  N   EGK+M   GSASS+TT+E    VP ARGRSQRTNRTQV+YV SDSDSEPV EDSDFD+ +
Subjt:  PEKKVRKIRASPSNKKSASILGMAGIEEEEEEDDDNNSDEEGKIMGGGGSASSDTTEESAGFVP-ARGRSQRTNRTQVKYVHSDSDSEPVAEDSDFDDKD

Query:  DDFDED
         + DED
Subjt:  DDFDED

XP_022152631.1 DNA topoisomerase 2 isoform X1 [Momordica charantia]

0.0e+00

88.59

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Query:  MVVEKKRPLQNSTAANVDQIPAGPKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYETDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMD
        M VEKKRPLQNST ANVD  PAGPKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYE DKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMD
Subjt:  MVVEKKRPLQNSTAANVDQIPAGPKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYETDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMD

Query:  SLKVVIDAEQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDDEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRQKKYKQVFSDNMGKKGE
        S+KVVID EQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDD  KKTTGGRNGYGAKLTNIFSTEFVIETADGKRQKKYKQVF DNMGKK E
Subjt:  SLKVVIDAEQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDDEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRQKKYKQVFSDNMGKKGE

Query:  PIITKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASPSTTDPPKRYHVKPNERWEIMV
        P+ITKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLD+AGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSAS   T+PPKRYH+KPNERWEI+V
Subjt:  PIITKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASPSTTDPPKRYHVKPNERWEIMV

Query:  TLSEGQFQQVSFVNGIATIKGGTHVDYITNQIANYVMNVVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSSFGSACELTPDFLKNV
        TLSEGQFQQVSFVN IATIKGGTHVDYITNQIANYVMNVVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSSFGS CELTP+FLKNV
Subjt:  TLSEGQFQQVSFVNGIATIKGGTHVDYITNQIANYVMNVVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSSFGSACELTPDFLKNV

Query:  AAKSGIMDSVLSWVNFKQSKDMKKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQIT
        A+KSGIMDSVLSWVNFKQSKD+KKTDGAKTEKISGIEKLEDANCAGG+NSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQIT
Subjt:  AAKSGIMDSVLSWVNFKQSKDMKKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQIT

Query:  ENKEIQYIKQILGLQQGKEYSNSKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWKESLR
        ENKEIQYIKQILGLQQGKEY+N K LRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLL+VPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWKESLR
Subjt:  ENKEIQYIKQILGLQQGKEYSNSKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWKESLR

Query:  GNANGWSIKYYKGLGTSTSKEGREYFEQLTRHKKDFIWQDDHDGEAIELAFSKKKIEERKNWLRHFEPGTHLDQTGKLIKYSDFVNKELILFSMADNLRS
        GNA+GWSIKYYKGLGTSTSKEGREYFEQL +HKKDF+WQDDHDGEAIELAFSKKKIEERKNWLRHFEPGTHLDQT KLIKYSDFVNKELILFSMAD  RS
Subjt:  GNANGWSIKYYKGLGTSTSKEGREYFEQLTRHKKDFIWQDDHDGEAIELAFSKKKIEERKNWLRHFEPGTHLDQTGKLIKYSDFVNKELILFSMADNLRS

Query:  IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLAGTIIGMAQDFVGSNNLNLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT
        IPS+VDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLA TIIGMAQDFVGSNN+NLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT
Subjt:  IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLAGTIIGMAQDFVGSNNLNLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT

Query:  RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGGEGIGTGWSTNIPNYNPRDIIRNVRRMLNDETMLPMDPWYRGFSGIIEKTATKDGCSSYTVS
        RFLFP+DDD+LLNYLNEDGQSIEPTWYMPIIPTVLVNG EGIGTGWS+ +PNYNPRDII NV+R+L+ ETM+PMDPWY+GFSGIIEKTATK+G  SYTVS
Subjt:  RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGGEGIGTGWSTNIPNYNPRDIIRNVRRMLNDETMLPMDPWYRGFSGIIEKTATKDGCSSYTVS

Query:  GIVEEVSDTTLRITELPVRKWTNDYKEFLDSVTR-TSKNDKDKEKAKDPFIEQADHHSDDKSVSIDVHLTDENMILAMQEGLKKKLKLTTTINTSNMHLF
        GI+EEVSDTTLRITELPVR+WTNDYKEFLDSVTR  +KNDK+K  AKDPFIEQADHHSDDK+VSIDVHLT+ENMILA+QEGLKKK KLTTT++TSNMHLF
Subjt:  GIVEEVSDTTLRITELPVRKWTNDYKEFLDSVTR-TSKNDKDKEKAKDPFIEQADHHSDDKSVSIDVHLTDENMILAMQEGLKKKLKLTTTINTSNMHLF

Query:  DANGMIKKYDTPEQILEEFFPLRLEYYEKRKRVLLENLEMELLKLENKARFILAVVNGEIIVSNRRRVDLVHELQAKGFTPFPKKTKSAEPEIAGASDET
        D+NG+IKKYDTPEQILEEFFPLRLEYYEKRK  LLENLE ELL+LENK RFILAVVNGEI+VSNRRRVDL HELQAKGFTPFPKKTKS EPE+AGAS+ET
Subjt:  DANGMIKKYDTPEQILEEFFPLRLEYYEKRKRVLLENLEMELLKLENKARFILAVVNGEIIVSNRRRVDLVHELQAKGFTPFPKKTKSAEPEIAGASDET

Query:  DQTEESPEVKGDRVSDYEYLLALAIGTLTIEKVQELCNDRDKLKGEVEDLRKATPKSLWLNDLDSLEKELDEMDRNDAHVDEVRKQQRI-ANNDVKPKIT
        D+ EESPE KG+RVSDY YLLALAIGTLTIEKVQELCNDRD+LKGEVEDLRKATPKSLWL DLD+LEKELDEMDRNDA  +EVRKQQRI ANNDVKPKI+
Subjt:  DQTEESPEVKGDRVSDYEYLLALAIGTLTIEKVQELCNDRDKLKGEVEDLRKATPKSLWLNDLDSLEKELDEMDRNDAHVDEVRKQQRI-ANNDVKPKIT

Query:  RN-APKAPRNSKKTSHSETAVESSMDTTSSSTTMEVESNAVVKPKGKAAAPRKAPAKKGKSAVVKDDAEDDDDEMLELKDRFAAYRIDSSPDRSEVSAME
        RN APKAPRNSKKT +SET  E SMDTTSSSTTMEV SNAVVKPKGK AAPRKAPAKKGK   V +  +DDDDE+LELKDR AAY+IDSSPDRSEVSAME
Subjt:  RN-APKAPRNSKKTSHSETAVESSMDTTSSSTTMEVESNAVVKPKGKAAAPRKAPAKKGKSAVVKDDAEDDDDEMLELKDRFAAYRIDSSPDRSEVSAME

Query:  TEAPQV-QAGKKKEPTKRAPAKKKTTAKSAQIS---DTDDEEFELKETGPPAGKKGGGGRKAAANAKTTKPPAPTKKREPAA-KVGQKLITKMLVPAENS
        TE PQV  A KKKEP+KRAPAKKKTTAKSAQIS   D+DD++FE+KE  PPA KKGGG  + AANAKTTKPPA  KKRE AA K+GQKLIT+ML P +N+
Subjt:  TEAPQV-QAGKKKEPTKRAPAKKKTTAKSAQIS---DTDDEEFELKETGPPAGKKGGGGRKAAANAKTTKPPAPTKKREPAA-KVGQKLITKMLVPAENS

Query:  GISPEKKVRKIRASPSNKKSASILGMAGIEEEEEEDDDNNSDEEGKIMGGGGSASSDTTEESAGFVPARGRSQRTNRTQVKYVHSDSDSEPVAEDSDFDD
        GISPEKKVRK+RASP NKKS SILG  G EEEEE +++ N   EGKIM   GSASS+T EESAGF+PARGRSQR NRTQVKYV SDSDS+PV E    DD
Subjt:  GISPEKKVRKIRASPSNKKSASILGMAGIEEEEEEDDDNNSDEEGKIMGGGGSASSDTTEESAGFVPARGRSQRTNRTQVKYVHSDSDSEPVAEDSDFDD

Query:  KDDDFDED
        KDDDFD++
Subjt:  KDDDFDED

XP_022152632.1 DNA topoisomerase 2 isoform X2 [Momordica charantia]

0.0e+00

88.46

Show/hide

Query:  MVVEKKRPLQNSTAANVDQIPAGPKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYETDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMD
        M VEKKRPLQNST ANVD  PAGPKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYE DKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMD
Subjt:  MVVEKKRPLQNSTAANVDQIPAGPKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYETDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMD

Query:  SLKVVIDAEQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDDEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRQKKYKQVFSDNMGKKGE
        S+KVVID EQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDD  KKTTGGRNGYGAKLTNIFSTEFVIETADGKRQKKYKQVF DNMGKK E
Subjt:  SLKVVIDAEQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDDEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRQKKYKQVFSDNMGKKGE

Query:  PIITKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASPSTTDPPKRYHVKPNERWEIMV
        P+ITKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLD+AGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSAS   T+PPKRYH+KPNERWEI+V
Subjt:  PIITKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASPSTTDPPKRYHVKPNERWEIMV

Query:  TLSEGQFQQVSFVNGIATIKGGTHVDYITNQIANYVMNVVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSSFGSACELTPDFLKNV
        TLSEGQFQQVSFVN IATIKGGTHVDYITNQIANYVMNVVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSSFGS CELTP+FLKNV
Subjt:  TLSEGQFQQVSFVNGIATIKGGTHVDYITNQIANYVMNVVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSSFGSACELTPDFLKNV

Query:  AAKSGIMDSVLSWVNFKQSKDMKKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQIT
        A+KSGIMDSVLSWVNFKQSKD+KKTDGAKTEKISGIEKLEDANCAGG+NSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQIT
Subjt:  AAKSGIMDSVLSWVNFKQSKDMKKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQIT

Query:  ENKEIQYIKQILGLQQGKEYSNSKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWKESLR
        ENKEIQYIKQILGLQQGKEY+N K LRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLL+VPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWKESLR
Subjt:  ENKEIQYIKQILGLQQGKEYSNSKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWKESLR

Query:  GNANGWSIKYYKGLGTSTSKEGREYFEQLTRHKKDFIWQDDHDGEAIELAFSKKKIEERKNWLRHFEPGTHLDQTGKLIKYSDFVNKELILFSMADNLRS
        GNA+GWSIKYYKGLGTSTSKEGREYFEQL +HKKDF+WQDDHDGEAIELAFSKKKIEERKNWLRHFEPGTHLDQT KLIKYSDFVNKELILFSMAD  RS
Subjt:  GNANGWSIKYYKGLGTSTSKEGREYFEQLTRHKKDFIWQDDHDGEAIELAFSKKKIEERKNWLRHFEPGTHLDQTGKLIKYSDFVNKELILFSMADNLRS

Query:  IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLAGTIIGMAQDFVGSNNLNLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT
        IPS+VDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLA TIIGMAQDFVGSNN+NLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT
Subjt:  IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLAGTIIGMAQDFVGSNNLNLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT

Query:  RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGGEGIGTGWSTNIPNYNPRDIIRNVRRMLNDETMLPMDPWYRGFSGIIEKTATKDGCSSYTVS
        RFLFP+DDD+LLNYLNEDGQSIEPTWYMPIIPTVLVNG EGIGTGWS+ +PNYNPRDII NV+R+L+ ETM+PMDPWY+GFSGIIEKTATK+G  SYTVS
Subjt:  RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGGEGIGTGWSTNIPNYNPRDIIRNVRRMLNDETMLPMDPWYRGFSGIIEKTATKDGCSSYTVS

Query:  GIVEEVSDTTLRITELPVRKWTNDYKEFLDSVTR-TSKNDKDKEKAKDPFIEQADHHSDDKSVSIDVHLTDENMILAMQEGLKKKLKLTTTINTSNMHLF
        GI+EEVSDTTLRITELPVR+WTNDYKEFLDSVTR  +KNDK+K  AKDPFIEQADHHSDDK+VSIDVHLT+ENMILA+QEGLKKK KLTTT++TSNMHLF
Subjt:  GIVEEVSDTTLRITELPVRKWTNDYKEFLDSVTR-TSKNDKDKEKAKDPFIEQADHHSDDKSVSIDVHLTDENMILAMQEGLKKKLKLTTTINTSNMHLF

Query:  DANGMIKKYDTPEQILEEFFPLRLEYYEKRKRVLLENLEMELLKLENKARFILAVVNGEIIVSNRRRVDLVHELQAKGFTPFPKKTKSAEPEIAGASDET
        D+NG+IKKYDTPEQILEEFFPLRLEYYEKRK  LLENLE ELL+LENK RFILAVVNGEI+VSNRRRVDL HELQAKGFTPFPKKTKS EPE+AGAS+ET
Subjt:  DANGMIKKYDTPEQILEEFFPLRLEYYEKRKRVLLENLEMELLKLENKARFILAVVNGEIIVSNRRRVDLVHELQAKGFTPFPKKTKSAEPEIAGASDET

Query:  DQTEESPEVKGDRVSDYEYLLALAIGTLTIEKVQELCNDRDKLKGEVEDLRKATPKSLWLNDLDSLEKELDEMDRNDAHVDEVRKQQRI-ANNDVKPKIT
        D+ EESPE KG+RVSDY YLLALAIGTLTIEKVQELCNDRD+LKGEVEDLRKATPKSLWL DLD+LEKELDEMDRNDA  +EVRKQQRI ANNDVKPKI+
Subjt:  DQTEESPEVKGDRVSDYEYLLALAIGTLTIEKVQELCNDRDKLKGEVEDLRKATPKSLWLNDLDSLEKELDEMDRNDAHVDEVRKQQRI-ANNDVKPKIT

Query:  RN-APKAPRNSKKTSHSETAVESSMDTTSSSTTMEVESNAVVKPKGKAAAPRKAPAKKGKSAVVKDDAEDDDDEMLELKDRFAAYRIDSSPDRSEVSAME
        RN APKAPRNSKKT +SET  E SMDTTSSSTTMEV SNAVVKPKGK AAPRKAPAKKGK   V +  +DDDDE+LELKDR AAY+IDSSPDRSE  AME
Subjt:  RN-APKAPRNSKKTSHSETAVESSMDTTSSSTTMEVESNAVVKPKGKAAAPRKAPAKKGKSAVVKDDAEDDDDEMLELKDRFAAYRIDSSPDRSEVSAME

Query:  TEAPQV-QAGKKKEPTKRAPAKKKTTAKSAQIS---DTDDEEFELKETGPPAGKKGGGGRKAAANAKTTKPPAPTKKREPAA-KVGQKLITKMLVPAENS
        TE PQV  A KKKEP+KRAPAKKKTTAKSAQIS   D+DD++FE+KE  PPA KKGGG  + AANAKTTKPPA  KKRE AA K+GQKLIT+ML P +N+
Subjt:  TEAPQV-QAGKKKEPTKRAPAKKKTTAKSAQIS---DTDDEEFELKETGPPAGKKGGGGRKAAANAKTTKPPAPTKKREPAA-KVGQKLITKMLVPAENS

Query:  GISPEKKVRKIRASPSNKKSASILGMAGIEEEEEEDDDNNSDEEGKIMGGGGSASSDTTEESAGFVPARGRSQRTNRTQVKYVHSDSDSEPVAEDSDFDD
        GISPEKKVRK+RASP NKKS SILG  G EEEEE +++ N   EGKIM   GSASS+T EESAGF+PARGRSQR NRTQVKYV SDSDS+PV E    DD
Subjt:  GISPEKKVRKIRASPSNKKSASILGMAGIEEEEEEDDDNNSDEEGKIMGGGGSASSDTTEESAGFVPARGRSQRTNRTQVKYVHSDSDSEPVAEDSDFDD

Query:  KDDDFDED
        KDDDFD++
Subjt:  KDDDFDED

XP_022935016.1 DNA topoisomerase 2 isoform X2 [Cucurbita moschata]

0.0e+00

88.51

Show/hide

Query:  MVVEKKRPLQNSTAANVDQIPAGPKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYETDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMD
        M VEKKRPLQNS AANVD  PAGPKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYE DKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMD
Subjt:  MVVEKKRPLQNSTAANVDQIPAGPKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYETDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMD

Query:  SLKVVIDAEQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDDEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRQKKYKQVFSDNMGKKGE
        SLKVVIDAEQN ISVFNNGDGVPVE+HQEEKVYVPELIFGHLLTSSNYDD EKKTTGGRNGYGAKLTNIFSTEFVIETADG+R KKYKQVFSDNMGKK E
Subjt:  SLKVVIDAEQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDDEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRQKKYKQVFSDNMGKKGE

Query:  PIITKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASPSTTDPPKRYHVKPNERWEIMV
        PIITKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVD YLKSA+   T+PPKRYH++PNERWEI+V
Subjt:  PIITKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASPSTTDPPKRYHVKPNERWEIMV

Query:  TLSEGQFQQVSFVNGIATIKGGTHVDYITNQIANYVMNVVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSSFGSACELTPDFLKNV
        TLSEGQFQQVSFVNGIATIKGGTHVDYITNQIANYVM VVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSSFGSACELTPDFLKNV
Subjt:  TLSEGQFQQVSFVNGIATIKGGTHVDYITNQIANYVMNVVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSSFGSACELTPDFLKNV

Query:  AAKSGIMDSVLSWVNFKQSKDMKKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQIT
        A KSGIMDSVLSWVNFKQSKD+KKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQIT
Subjt:  AAKSGIMDSVLSWVNFKQSKDMKKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQIT

Query:  ENKEIQYIKQILGLQQGKEYSNSKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWKESLR
        ENKEIQYIKQILGLQQGKEY+N+KALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLL+VPSFLVEFITPIVKATHRNGTVLSFYTMPEYE+WK++LR
Subjt:  ENKEIQYIKQILGLQQGKEYSNSKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWKESLR

Query:  GNANGWSIKYYKGLGTSTSKEGREYFEQLTRHKKDFIWQDDHDGEAIELAFSKKKIEERKNWLRHFEPGTHLDQTGKLIKYSDFVNKELILFSMADNLRS
        GNA+GWSIKYYKGLGTSTSKEGREYFEQL +HKKDFIWQD+HDGEAIELAFSKKKIEERKNWLR FE GTHLDQ+ KLIKYSDFVNKELILFSMAD  RS
Subjt:  GNANGWSIKYYKGLGTSTSKEGREYFEQLTRHKKDFIWQDDHDGEAIELAFSKKKIEERKNWLRHFEPGTHLDQTGKLIKYSDFVNKELILFSMADNLRS

Query:  IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLAGTIIGMAQDFVGSNNLNLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT
        IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLA TIIGMAQDFVGSNN+NLLLPNGQFGTRNHGGKDHASSRYIYTKLSN T
Subjt:  IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLAGTIIGMAQDFVGSNNLNLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT

Query:  RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGGEGIGTGWSTNIPNYNPRDIIRNVRRMLNDETMLPMDPWYRGFSGIIEKTATKDGCSSYTVS
        RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNG EGIGTGWS+ IPNYNPRDIIRNVRRMLN E MLPMDPWYRGFSG IEKTATK+G +SYTVS
Subjt:  RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGGEGIGTGWSTNIPNYNPRDIIRNVRRMLNDETMLPMDPWYRGFSGIIEKTATKDGCSSYTVS

Query:  GIVEEVSDTTLRITELPVRKWTNDYKEFLDSVTRTS-KNDKDKEK-AKDPFIEQADHHSDDKSVSIDVHLTDENMILAMQEGLKKKLKLTTTINTSNMHL
        GI+EEVSDTTLRITELPVR+WTNDYK+FLDSVTR S KNDKDKEK AKDPFIEQADHHSDDK+VSIDVHLT+ENMILAMQEGLKKK KLTTT++TSNMHL
Subjt:  GIVEEVSDTTLRITELPVRKWTNDYKEFLDSVTRTS-KNDKDKEK-AKDPFIEQADHHSDDKSVSIDVHLTDENMILAMQEGLKKKLKLTTTINTSNMHL

Query:  FDANGMIKKYDTPEQILEEFFPLRLEYYEKRKRVLLENLEMELLKLENKARFILAVVNGEIIVSNRRRVDLVHELQAKGFTPFPKKTKSAEPEIAGASDE
        FDANG+IKKYDTPEQILEEFFPLRLE++EKRKR LLENLE ELLKLENK RFILAVVNGEIIVSNRRRVDL HELQ KGFTPFPKKTKS EPE+AGAS+E
Subjt:  FDANGMIKKYDTPEQILEEFFPLRLEYYEKRKRVLLENLEMELLKLENKARFILAVVNGEIIVSNRRRVDLVHELQAKGFTPFPKKTKSAEPEIAGASDE

Query:  TDQTEESPE-VKGDRVSDYEYLLALAIGTLTIEKVQELCNDRDKLKGEVEDLRKATPKSLWLNDLDSLEKELDEMDRNDAHVDEVRKQQRIANNDVKPKI
        TD+ EESPE VKG+RVSDYEYLLALAIGTLTIEKVQELCN+RDK KGEVE+LRKATPKSLWL DLD LEKELDEMDRNDA  DEVRKQQRI NND+KPKI
Subjt:  TDQTEESPE-VKGDRVSDYEYLLALAIGTLTIEKVQELCNDRDKLKGEVEDLRKATPKSLWLNDLDSLEKELDEMDRNDAHVDEVRKQQRIANNDVKPKI

Query:  TRNAPKAPRNSKKTSHSETAVESSMDTTSSSTTMEVESNAVVKPKGKAAAPRKAPAKKGKSAVVKDDAEDDDDEMLELKDRFAAYRIDSSPDRSEVSAME
        +RNAPKAPRNSKKTS+SET  ES   TTSSSTT EV +N VVKPKGK AAPRKAPAKKGK+AV+ D   DDDDE+LELKDR AAY+++SSP+ SEVSAME
Subjt:  TRNAPKAPRNSKKTSHSETAVESSMDTTSSSTTMEVESNAVVKPKGKAAAPRKAPAKKGKSAVVKDDAEDDDDEMLELKDRFAAYRIDSSPDRSEVSAME

Query:  TEAPQVQ-AGKKKEPTKRAPAKKKTTAKSAQIS-DTDDEEFELKETGPPAGKKGGGGRKAAANAKTTKPPAPTKKREPAAKVGQKLITKMLVPAENSGIS
        TE P+VQ A KKKEP+KRA AKKKTTAKSAQIS D+DD +FE+KE  PPA KK GGGRKAAANAKTTK    TKK+EP A++GQKLIT+ML P ENSGIS
Subjt:  TEAPQVQ-AGKKKEPTKRAPAKKKTTAKSAQIS-DTDDEEFELKETGPPAGKKGGGGRKAAANAKTTKPPAPTKKREPAAKVGQKLITKMLVPAENSGIS

Query:  PEKKVRKIRASPSNKKSASILGMAGIEEEEEEDDDNNSDEEGKIMGGGGSASSDTTEESAGFVP-ARGRSQRTNRTQVKYVHSDSDSEPVAEDSDFDDKD
        PEKKVRKIR SP NKKS S+LG    EEEEE ++  N   EGK+M   GSASS+TT+E    VP ARGRSQRTNRTQV+YV SDSDSEPV EDSDFD+ +
Subjt:  PEKKVRKIRASPSNKKSASILGMAGIEEEEEEDDDNNSDEEGKIMGGGGSASSDTTEESAGFVP-ARGRSQRTNRTQVKYVHSDSDSEPVAEDSDFDDKD

Query:  DDFDED
         + DED
Subjt:  DDFDED

XP_023527823.1 DNA topoisomerase 2 isoform X3 [Cucurbita pepo subsp. pepo]

0.0e+00

88.51

Show/hide

Query:  MVVEKKRPLQNSTAANVDQIPAGPKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYETDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMD
        M VEKKRPLQNS AANVD  P GPKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLW+YE DKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMD
Subjt:  MVVEKKRPLQNSTAANVDQIPAGPKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYETDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMD

Query:  SLKVVIDAEQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDDEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRQKKYKQVFSDNMGKKGE
        SLKVVIDAEQN ISVFNNGDGVPVE+HQEEKVYVPELIFGHLLTSSNYDD EKKTTGGRNGYGAKLTNIFSTEFVIETADG+R KKYKQVFSDNMGKK E
Subjt:  SLKVVIDAEQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDDEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRQKKYKQVFSDNMGKKGE

Query:  PIITKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASPSTTDPPKRYHVKPNERWEIMV
        PIITKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVD YLKSA+   T+PPKRYH++PNERWEI+V
Subjt:  PIITKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASPSTTDPPKRYHVKPNERWEIMV

Query:  TLSEGQFQQVSFVNGIATIKGGTHVDYITNQIANYVMNVVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSSFGSACELTPDFLKNV
        TLSEGQFQQVSFVNGIATIKGGTHVDYITNQIANYVM VVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSSFGSACELTPDFLKNV
Subjt:  TLSEGQFQQVSFVNGIATIKGGTHVDYITNQIANYVMNVVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSSFGSACELTPDFLKNV

Query:  AAKSGIMDSVLSWVNFKQSKDMKKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQIT
        A KSGIMDSVLSWVNFKQSKD+KKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQIT
Subjt:  AAKSGIMDSVLSWVNFKQSKDMKKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQIT

Query:  ENKEIQYIKQILGLQQGKEYSNSKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWKESLR
        ENKEIQYIKQILGLQQGKEY+N+KALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLL+VPSFLVEFITPIVKATHRNGTVLSFYTMPEYE+WK++LR
Subjt:  ENKEIQYIKQILGLQQGKEYSNSKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWKESLR

Query:  GNANGWSIKYYKGLGTSTSKEGREYFEQLTRHKKDFIWQDDHDGEAIELAFSKKKIEERKNWLRHFEPGTHLDQTGKLIKYSDFVNKELILFSMADNLRS
        GNA+GWSIKYYKGLGTSTSKEGREYFEQL +HKKDFIWQD+HDGEAIELAFSKKKIEERKNWLR FE GTHLDQ+ KLIKYSDFVNKELILFSMAD  RS
Subjt:  GNANGWSIKYYKGLGTSTSKEGREYFEQLTRHKKDFIWQDDHDGEAIELAFSKKKIEERKNWLRHFEPGTHLDQTGKLIKYSDFVNKELILFSMADNLRS

Query:  IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLAGTIIGMAQDFVGSNNLNLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT
        IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLA TIIGMAQDFVGSNN+NLLLPNGQFGTRNHGGKDHASSRYIYTKLSN T
Subjt:  IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLAGTIIGMAQDFVGSNNLNLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT

Query:  RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGGEGIGTGWSTNIPNYNPRDIIRNVRRMLNDETMLPMDPWYRGFSGIIEKTATKDGCSSYTVS
        RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNG EGIGTGWS+ IPNYNPRDIIRNVRRMLN E MLPMDPWYRGFSG IEKTATK+G +SYTVS
Subjt:  RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGGEGIGTGWSTNIPNYNPRDIIRNVRRMLNDETMLPMDPWYRGFSGIIEKTATKDGCSSYTVS

Query:  GIVEEVSDTTLRITELPVRKWTNDYKEFLDSVTRTS-KNDKDKEK-AKDPFIEQADHHSDDKSVSIDVHLTDENMILAMQEGLKKKLKLTTTINTSNMHL
        GI+EEVSDTTLRITELPVR+WTNDYK+FLDSVTR S KNDKDKEK AKDPFIEQADHHSDDK+VSIDVHLT+ENMILAMQEGLKKK KLTTT++TSNMHL
Subjt:  GIVEEVSDTTLRITELPVRKWTNDYKEFLDSVTRTS-KNDKDKEK-AKDPFIEQADHHSDDKSVSIDVHLTDENMILAMQEGLKKKLKLTTTINTSNMHL

Query:  FDANGMIKKYDTPEQILEEFFPLRLEYYEKRKRVLLENLEMELLKLENKARFILAVVNGEIIVSNRRRVDLVHELQAKGFTPFPKKTKSAEPEIAGASDE
        FDANG+IKKYDTPEQILEEFFPLRLE++EKRKR LLENLE ELLKLENK RFILAVVNGEIIVSNRRRVDL HELQ KGFTPFPKKTKS EPE+AGAS+E
Subjt:  FDANGMIKKYDTPEQILEEFFPLRLEYYEKRKRVLLENLEMELLKLENKARFILAVVNGEIIVSNRRRVDLVHELQAKGFTPFPKKTKSAEPEIAGASDE

Query:  TDQTEESPE-VKGDRVSDYEYLLALAIGTLTIEKVQELCNDRDKLKGEVEDLRKATPKSLWLNDLDSLEKELDEMDRNDAHVDEVRKQQRIANNDVKPKI
        TD+ EESPE VKG+RVSDYEYLLALAIGTLTIEKVQELCN+RDK KGEVE+LRKATPKSLWL DLD LEKELDEMDRNDA  DEVRKQQRI NNDVKPKI
Subjt:  TDQTEESPE-VKGDRVSDYEYLLALAIGTLTIEKVQELCNDRDKLKGEVEDLRKATPKSLWLNDLDSLEKELDEMDRNDAHVDEVRKQQRIANNDVKPKI

Query:  TRNAPKAPRNSKKTSHSETAVESSMDTTSSSTTMEVESNAVVKPKGKAAAPRKAPAKKGKSAVVKDDAEDDDDEMLELKDRFAAYRIDSSPDRSEVSAME
        +RNAPKAPRNSKKTS+SET  ES   TTSSSTT EV +N VVKPKGK AAPRKAPAKKGK+AV+ D   DDDDE+LELKDR AAY+++SSP+ SEVSAME
Subjt:  TRNAPKAPRNSKKTSHSETAVESSMDTTSSSTTMEVESNAVVKPKGKAAAPRKAPAKKGKSAVVKDDAEDDDDEMLELKDRFAAYRIDSSPDRSEVSAME

Query:  TEAPQVQ-AGKKKEPTKRAPAKKKTTAKSAQIS-DTDDEEFELKETGPPAGKKGGGGRKAAANAKTTKPPAPTKKREPAAKVGQKLITKMLVPAENSGIS
        TE P+VQ A KKKEP+KRA AKKKTTAKSAQIS D+D+ +FE+KE  PPA KK GGGRKAAANAKTTK    TKK+EP A++GQKLIT+ML P ENSGIS
Subjt:  TEAPQVQ-AGKKKEPTKRAPAKKKTTAKSAQIS-DTDDEEFELKETGPPAGKKGGGGRKAAANAKTTKPPAPTKKREPAAKVGQKLITKMLVPAENSGIS

Query:  PEKKVRKIRASPSNKKSASILGMAGIEEEEEEDDDNNSDEEGKIMGGGGSASSDTTEESAGFVP-ARGRSQRTNRTQVKYVHSDSDSEPVAEDSDFDDKD
        PEKKVRKIR SP NKKS S+LG    EEEEE +  N    EGK+M   GSASS+TT+E  G VP ARGRSQRTNRTQV+YV SDSDSEPV EDSDFD+ +
Subjt:  PEKKVRKIRASPSNKKSASILGMAGIEEEEEEDDDNNSDEEGKIMGGGGSASSDTTEESAGFVP-ARGRSQRTNRTQVKYVHSDSDSEPVAEDSDFDDKD

Query:  DDFDED
         D DED
Subjt:  DDFDED

TrEMBL top hits

e value

%identity

Alignment

A0A6J1DGT3 DNA topoisomerase 2

0.0e+00

88.46

Show/hide

Query:  MVVEKKRPLQNSTAANVDQIPAGPKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYETDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMD
        M VEKKRPLQNST ANVD  PAGPKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYE DKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMD
Subjt:  MVVEKKRPLQNSTAANVDQIPAGPKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYETDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMD

Query:  SLKVVIDAEQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDDEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRQKKYKQVFSDNMGKKGE
        S+KVVID EQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDD  KKTTGGRNGYGAKLTNIFSTEFVIETADGKRQKKYKQVF DNMGKK E
Subjt:  SLKVVIDAEQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDDEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRQKKYKQVFSDNMGKKGE

Query:  PIITKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASPSTTDPPKRYHVKPNERWEIMV
        P+ITKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLD+AGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSAS   T+PPKRYH+KPNERWEI+V
Subjt:  PIITKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASPSTTDPPKRYHVKPNERWEIMV

Query:  TLSEGQFQQVSFVNGIATIKGGTHVDYITNQIANYVMNVVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSSFGSACELTPDFLKNV
        TLSEGQFQQVSFVN IATIKGGTHVDYITNQIANYVMNVVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSSFGS CELTP+FLKNV
Subjt:  TLSEGQFQQVSFVNGIATIKGGTHVDYITNQIANYVMNVVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSSFGSACELTPDFLKNV

Query:  AAKSGIMDSVLSWVNFKQSKDMKKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQIT
        A+KSGIMDSVLSWVNFKQSKD+KKTDGAKTEKISGIEKLEDANCAGG+NSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQIT
Subjt:  AAKSGIMDSVLSWVNFKQSKDMKKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQIT

Query:  ENKEIQYIKQILGLQQGKEYSNSKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWKESLR
        ENKEIQYIKQILGLQQGKEY+N K LRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLL+VPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWKESLR
Subjt:  ENKEIQYIKQILGLQQGKEYSNSKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWKESLR

Query:  GNANGWSIKYYKGLGTSTSKEGREYFEQLTRHKKDFIWQDDHDGEAIELAFSKKKIEERKNWLRHFEPGTHLDQTGKLIKYSDFVNKELILFSMADNLRS
        GNA+GWSIKYYKGLGTSTSKEGREYFEQL +HKKDF+WQDDHDGEAIELAFSKKKIEERKNWLRHFEPGTHLDQT KLIKYSDFVNKELILFSMAD  RS
Subjt:  GNANGWSIKYYKGLGTSTSKEGREYFEQLTRHKKDFIWQDDHDGEAIELAFSKKKIEERKNWLRHFEPGTHLDQTGKLIKYSDFVNKELILFSMADNLRS

Query:  IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLAGTIIGMAQDFVGSNNLNLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT
        IPS+VDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLA TIIGMAQDFVGSNN+NLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT
Subjt:  IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLAGTIIGMAQDFVGSNNLNLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT

Query:  RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGGEGIGTGWSTNIPNYNPRDIIRNVRRMLNDETMLPMDPWYRGFSGIIEKTATKDGCSSYTVS
        RFLFP+DDD+LLNYLNEDGQSIEPTWYMPIIPTVLVNG EGIGTGWS+ +PNYNPRDII NV+R+L+ ETM+PMDPWY+GFSGIIEKTATK+G  SYTVS
Subjt:  RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGGEGIGTGWSTNIPNYNPRDIIRNVRRMLNDETMLPMDPWYRGFSGIIEKTATKDGCSSYTVS

Query:  GIVEEVSDTTLRITELPVRKWTNDYKEFLDSVTR-TSKNDKDKEKAKDPFIEQADHHSDDKSVSIDVHLTDENMILAMQEGLKKKLKLTTTINTSNMHLF
        GI+EEVSDTTLRITELPVR+WTNDYKEFLDSVTR  +KNDK+K  AKDPFIEQADHHSDDK+VSIDVHLT+ENMILA+QEGLKKK KLTTT++TSNMHLF
Subjt:  GIVEEVSDTTLRITELPVRKWTNDYKEFLDSVTR-TSKNDKDKEKAKDPFIEQADHHSDDKSVSIDVHLTDENMILAMQEGLKKKLKLTTTINTSNMHLF

Query:  DANGMIKKYDTPEQILEEFFPLRLEYYEKRKRVLLENLEMELLKLENKARFILAVVNGEIIVSNRRRVDLVHELQAKGFTPFPKKTKSAEPEIAGASDET
        D+NG+IKKYDTPEQILEEFFPLRLEYYEKRK  LLENLE ELL+LENK RFILAVVNGEI+VSNRRRVDL HELQAKGFTPFPKKTKS EPE+AGAS+ET
Subjt:  DANGMIKKYDTPEQILEEFFPLRLEYYEKRKRVLLENLEMELLKLENKARFILAVVNGEIIVSNRRRVDLVHELQAKGFTPFPKKTKSAEPEIAGASDET

Query:  DQTEESPEVKGDRVSDYEYLLALAIGTLTIEKVQELCNDRDKLKGEVEDLRKATPKSLWLNDLDSLEKELDEMDRNDAHVDEVRKQQRI-ANNDVKPKIT
        D+ EESPE KG+RVSDY YLLALAIGTLTIEKVQELCNDRD+LKGEVEDLRKATPKSLWL DLD+LEKELDEMDRNDA  +EVRKQQRI ANNDVKPKI+
Subjt:  DQTEESPEVKGDRVSDYEYLLALAIGTLTIEKVQELCNDRDKLKGEVEDLRKATPKSLWLNDLDSLEKELDEMDRNDAHVDEVRKQQRI-ANNDVKPKIT

Query:  RN-APKAPRNSKKTSHSETAVESSMDTTSSSTTMEVESNAVVKPKGKAAAPRKAPAKKGKSAVVKDDAEDDDDEMLELKDRFAAYRIDSSPDRSEVSAME
        RN APKAPRNSKKT +SET  E SMDTTSSSTTMEV SNAVVKPKGK AAPRKAPAKKGK   V +  +DDDDE+LELKDR AAY+IDSSPDRSE  AME
Subjt:  RN-APKAPRNSKKTSHSETAVESSMDTTSSSTTMEVESNAVVKPKGKAAAPRKAPAKKGKSAVVKDDAEDDDDEMLELKDRFAAYRIDSSPDRSEVSAME

Query:  TEAPQV-QAGKKKEPTKRAPAKKKTTAKSAQIS---DTDDEEFELKETGPPAGKKGGGGRKAAANAKTTKPPAPTKKREPAA-KVGQKLITKMLVPAENS
        TE PQV  A KKKEP+KRAPAKKKTTAKSAQIS   D+DD++FE+KE  PPA KKGGG  + AANAKTTKPPA  KKRE AA K+GQKLIT+ML P +N+
Subjt:  TEAPQV-QAGKKKEPTKRAPAKKKTTAKSAQIS---DTDDEEFELKETGPPAGKKGGGGRKAAANAKTTKPPAPTKKREPAA-KVGQKLITKMLVPAENS

Query:  GISPEKKVRKIRASPSNKKSASILGMAGIEEEEEEDDDNNSDEEGKIMGGGGSASSDTTEESAGFVPARGRSQRTNRTQVKYVHSDSDSEPVAEDSDFDD
        GISPEKKVRK+RASP NKKS SILG  G EEEEE +++ N   EGKIM   GSASS+T EESAGF+PARGRSQR NRTQVKYV SDSDS+PV E    DD
Subjt:  GISPEKKVRKIRASPSNKKSASILGMAGIEEEEEEDDDNNSDEEGKIMGGGGSASSDTTEESAGFVPARGRSQRTNRTQVKYVHSDSDSEPVAEDSDFDD

Query:  KDDDFDED
        KDDDFD++
Subjt:  KDDDFDED

A0A6J1DIB5 DNA topoisomerase 2

0.0e+00

88.59

Show/hide

Query:  MVVEKKRPLQNSTAANVDQIPAGPKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYETDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMD
        M VEKKRPLQNST ANVD  PAGPKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYE DKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMD
Subjt:  MVVEKKRPLQNSTAANVDQIPAGPKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYETDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMD

Query:  SLKVVIDAEQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDDEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRQKKYKQVFSDNMGKKGE
        S+KVVID EQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDD  KKTTGGRNGYGAKLTNIFSTEFVIETADGKRQKKYKQVF DNMGKK E
Subjt:  SLKVVIDAEQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDDEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRQKKYKQVFSDNMGKKGE

Query:  PIITKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASPSTTDPPKRYHVKPNERWEIMV
        P+ITKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLD+AGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSAS   T+PPKRYH+KPNERWEI+V
Subjt:  PIITKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASPSTTDPPKRYHVKPNERWEIMV

Query:  TLSEGQFQQVSFVNGIATIKGGTHVDYITNQIANYVMNVVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSSFGSACELTPDFLKNV
        TLSEGQFQQVSFVN IATIKGGTHVDYITNQIANYVMNVVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSSFGS CELTP+FLKNV
Subjt:  TLSEGQFQQVSFVNGIATIKGGTHVDYITNQIANYVMNVVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSSFGSACELTPDFLKNV

Query:  AAKSGIMDSVLSWVNFKQSKDMKKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQIT
        A+KSGIMDSVLSWVNFKQSKD+KKTDGAKTEKISGIEKLEDANCAGG+NSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQIT
Subjt:  AAKSGIMDSVLSWVNFKQSKDMKKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQIT

Query:  ENKEIQYIKQILGLQQGKEYSNSKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWKESLR
        ENKEIQYIKQILGLQQGKEY+N K LRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLL+VPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWKESLR
Subjt:  ENKEIQYIKQILGLQQGKEYSNSKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWKESLR

Query:  GNANGWSIKYYKGLGTSTSKEGREYFEQLTRHKKDFIWQDDHDGEAIELAFSKKKIEERKNWLRHFEPGTHLDQTGKLIKYSDFVNKELILFSMADNLRS
        GNA+GWSIKYYKGLGTSTSKEGREYFEQL +HKKDF+WQDDHDGEAIELAFSKKKIEERKNWLRHFEPGTHLDQT KLIKYSDFVNKELILFSMAD  RS
Subjt:  GNANGWSIKYYKGLGTSTSKEGREYFEQLTRHKKDFIWQDDHDGEAIELAFSKKKIEERKNWLRHFEPGTHLDQTGKLIKYSDFVNKELILFSMADNLRS

Query:  IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLAGTIIGMAQDFVGSNNLNLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT
        IPS+VDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLA TIIGMAQDFVGSNN+NLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT
Subjt:  IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLAGTIIGMAQDFVGSNNLNLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT

Query:  RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGGEGIGTGWSTNIPNYNPRDIIRNVRRMLNDETMLPMDPWYRGFSGIIEKTATKDGCSSYTVS
        RFLFP+DDD+LLNYLNEDGQSIEPTWYMPIIPTVLVNG EGIGTGWS+ +PNYNPRDII NV+R+L+ ETM+PMDPWY+GFSGIIEKTATK+G  SYTVS
Subjt:  RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGGEGIGTGWSTNIPNYNPRDIIRNVRRMLNDETMLPMDPWYRGFSGIIEKTATKDGCSSYTVS

Query:  GIVEEVSDTTLRITELPVRKWTNDYKEFLDSVTR-TSKNDKDKEKAKDPFIEQADHHSDDKSVSIDVHLTDENMILAMQEGLKKKLKLTTTINTSNMHLF
        GI+EEVSDTTLRITELPVR+WTNDYKEFLDSVTR  +KNDK+K  AKDPFIEQADHHSDDK+VSIDVHLT+ENMILA+QEGLKKK KLTTT++TSNMHLF
Subjt:  GIVEEVSDTTLRITELPVRKWTNDYKEFLDSVTR-TSKNDKDKEKAKDPFIEQADHHSDDKSVSIDVHLTDENMILAMQEGLKKKLKLTTTINTSNMHLF

Query:  DANGMIKKYDTPEQILEEFFPLRLEYYEKRKRVLLENLEMELLKLENKARFILAVVNGEIIVSNRRRVDLVHELQAKGFTPFPKKTKSAEPEIAGASDET
        D+NG+IKKYDTPEQILEEFFPLRLEYYEKRK  LLENLE ELL+LENK RFILAVVNGEI+VSNRRRVDL HELQAKGFTPFPKKTKS EPE+AGAS+ET
Subjt:  DANGMIKKYDTPEQILEEFFPLRLEYYEKRKRVLLENLEMELLKLENKARFILAVVNGEIIVSNRRRVDLVHELQAKGFTPFPKKTKSAEPEIAGASDET

Query:  DQTEESPEVKGDRVSDYEYLLALAIGTLTIEKVQELCNDRDKLKGEVEDLRKATPKSLWLNDLDSLEKELDEMDRNDAHVDEVRKQQRI-ANNDVKPKIT
        D+ EESPE KG+RVSDY YLLALAIGTLTIEKVQELCNDRD+LKGEVEDLRKATPKSLWL DLD+LEKELDEMDRNDA  +EVRKQQRI ANNDVKPKI+
Subjt:  DQTEESPEVKGDRVSDYEYLLALAIGTLTIEKVQELCNDRDKLKGEVEDLRKATPKSLWLNDLDSLEKELDEMDRNDAHVDEVRKQQRI-ANNDVKPKIT

Query:  RN-APKAPRNSKKTSHSETAVESSMDTTSSSTTMEVESNAVVKPKGKAAAPRKAPAKKGKSAVVKDDAEDDDDEMLELKDRFAAYRIDSSPDRSEVSAME
        RN APKAPRNSKKT +SET  E SMDTTSSSTTMEV SNAVVKPKGK AAPRKAPAKKGK   V +  +DDDDE+LELKDR AAY+IDSSPDRSEVSAME
Subjt:  RN-APKAPRNSKKTSHSETAVESSMDTTSSSTTMEVESNAVVKPKGKAAAPRKAPAKKGKSAVVKDDAEDDDDEMLELKDRFAAYRIDSSPDRSEVSAME

Query:  TEAPQV-QAGKKKEPTKRAPAKKKTTAKSAQIS---DTDDEEFELKETGPPAGKKGGGGRKAAANAKTTKPPAPTKKREPAA-KVGQKLITKMLVPAENS
        TE PQV  A KKKEP+KRAPAKKKTTAKSAQIS   D+DD++FE+KE  PPA KKGGG  + AANAKTTKPPA  KKRE AA K+GQKLIT+ML P +N+
Subjt:  TEAPQV-QAGKKKEPTKRAPAKKKTTAKSAQIS---DTDDEEFELKETGPPAGKKGGGGRKAAANAKTTKPPAPTKKREPAA-KVGQKLITKMLVPAENS

Query:  GISPEKKVRKIRASPSNKKSASILGMAGIEEEEEEDDDNNSDEEGKIMGGGGSASSDTTEESAGFVPARGRSQRTNRTQVKYVHSDSDSEPVAEDSDFDD
        GISPEKKVRK+RASP NKKS SILG  G EEEEE +++ N   EGKIM   GSASS+T EESAGF+PARGRSQR NRTQVKYV SDSDS+PV E    DD
Subjt:  GISPEKKVRKIRASPSNKKSASILGMAGIEEEEEEDDDNNSDEEGKIMGGGGSASSDTTEESAGFVPARGRSQRTNRTQVKYVHSDSDSEPVAEDSDFDD

Query:  KDDDFDED
        KDDDFD++
Subjt:  KDDDFDED

A0A6J1F3D6 DNA topoisomerase 2

0.0e+00

88.51

Show/hide

Query:  MVVEKKRPLQNSTAANVDQIPAGPKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYETDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMD
        M VEKKRPLQNS AANVD  PAGPKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYE DKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMD
Subjt:  MVVEKKRPLQNSTAANVDQIPAGPKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYETDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMD

Query:  SLKVVIDAEQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDDEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRQKKYKQVFSDNMGKKGE
        SLKVVIDAEQN ISVFNNGDGVPVE+HQEEKVYVPELIFGHLLTSSNYDD EKKTTGGRNGYGAKLTNIFSTEFVIETADG+R KKYKQVFSDNMGKK E
Subjt:  SLKVVIDAEQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDDEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRQKKYKQVFSDNMGKKGE

Query:  PIITKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASPSTTDPPKRYHVKPNERWEIMV
        PIITKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVD YLKSA+   T+PPKRYH++PNERWEI+V
Subjt:  PIITKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASPSTTDPPKRYHVKPNERWEIMV

Query:  TLSEGQFQQVSFVNGIATIKGGTHVDYITNQIANYVMNVVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSSFGSACELTPDFLKNV
        TLSEGQFQQVSFVNGIATIKGGTHVDYITNQIANYVM VVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSSFGSACELTPDFLKNV
Subjt:  TLSEGQFQQVSFVNGIATIKGGTHVDYITNQIANYVMNVVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSSFGSACELTPDFLKNV

Query:  AAKSGIMDSVLSWVNFKQSKDMKKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQIT
        A KSGIMDSVLSWVNFKQSKD+KKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQIT
Subjt:  AAKSGIMDSVLSWVNFKQSKDMKKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQIT

Query:  ENKEIQYIKQILGLQQGKEYSNSKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWKESLR
        ENKEIQYIKQILGLQQGKEY+N+KALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLL+VPSFLVEFITPIVKATHRNGTVLSFYTMPEYE+WK++LR
Subjt:  ENKEIQYIKQILGLQQGKEYSNSKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWKESLR

Query:  GNANGWSIKYYKGLGTSTSKEGREYFEQLTRHKKDFIWQDDHDGEAIELAFSKKKIEERKNWLRHFEPGTHLDQTGKLIKYSDFVNKELILFSMADNLRS
        GNA+GWSIKYYKGLGTSTSKEGREYFEQL +HKKDFIWQD+HDGEAIELAFSKKKIEERKNWLR FE GTHLDQ+ KLIKYSDFVNKELILFSMAD  RS
Subjt:  GNANGWSIKYYKGLGTSTSKEGREYFEQLTRHKKDFIWQDDHDGEAIELAFSKKKIEERKNWLRHFEPGTHLDQTGKLIKYSDFVNKELILFSMADNLRS

Query:  IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLAGTIIGMAQDFVGSNNLNLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT
        IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLA TIIGMAQDFVGSNN+NLLLPNGQFGTRNHGGKDHASSRYIYTKLSN T
Subjt:  IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLAGTIIGMAQDFVGSNNLNLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT

Query:  RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGGEGIGTGWSTNIPNYNPRDIIRNVRRMLNDETMLPMDPWYRGFSGIIEKTATKDGCSSYTVS
        RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNG EGIGTGWS+ IPNYNPRDIIRNVRRMLN E MLPMDPWYRGFSG IEKTATK+G +SYTVS
Subjt:  RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGGEGIGTGWSTNIPNYNPRDIIRNVRRMLNDETMLPMDPWYRGFSGIIEKTATKDGCSSYTVS

Query:  GIVEEVSDTTLRITELPVRKWTNDYKEFLDSVTRTS-KNDKDKEK-AKDPFIEQADHHSDDKSVSIDVHLTDENMILAMQEGLKKKLKLTTTINTSNMHL
        GI+EEVSDTTLRITELPVR+WTNDYK+FLDSVTR S KNDKDKEK AKDPFIEQADHHSDDK+VSIDVHLT+ENMILAMQEGLKKK KLTTT++TSNMHL
Subjt:  GIVEEVSDTTLRITELPVRKWTNDYKEFLDSVTRTS-KNDKDKEK-AKDPFIEQADHHSDDKSVSIDVHLTDENMILAMQEGLKKKLKLTTTINTSNMHL

Query:  FDANGMIKKYDTPEQILEEFFPLRLEYYEKRKRVLLENLEMELLKLENKARFILAVVNGEIIVSNRRRVDLVHELQAKGFTPFPKKTKSAEPEIAGASDE
        FDANG+IKKYDTPEQILEEFFPLRLE++EKRKR LLENLE ELLKLENK RFILAVVNGEIIVSNRRRVDL HELQ KGFTPFPKKTKS EPE+AGAS+E
Subjt:  FDANGMIKKYDTPEQILEEFFPLRLEYYEKRKRVLLENLEMELLKLENKARFILAVVNGEIIVSNRRRVDLVHELQAKGFTPFPKKTKSAEPEIAGASDE

Query:  TDQTEESPE-VKGDRVSDYEYLLALAIGTLTIEKVQELCNDRDKLKGEVEDLRKATPKSLWLNDLDSLEKELDEMDRNDAHVDEVRKQQRIANNDVKPKI
        TD+ EESPE VKG+RVSDYEYLLALAIGTLTIEKVQELCN+RDK KGEVE+LRKATPKSLWL DLD LEKELDEMDRNDA  DEVRKQQRI NND+KPKI
Subjt:  TDQTEESPE-VKGDRVSDYEYLLALAIGTLTIEKVQELCNDRDKLKGEVEDLRKATPKSLWLNDLDSLEKELDEMDRNDAHVDEVRKQQRIANNDVKPKI

Query:  TRNAPKAPRNSKKTSHSETAVESSMDTTSSSTTMEVESNAVVKPKGKAAAPRKAPAKKGKSAVVKDDAEDDDDEMLELKDRFAAYRIDSSPDRSEVSAME
        +RNAPKAPRNSKKTS+SET  ES   TTSSSTT EV +N VVKPKGK AAPRKAPAKKGK+AV+ D   DDDDE+LELKDR AAY+++SSP+ SEVSAME
Subjt:  TRNAPKAPRNSKKTSHSETAVESSMDTTSSSTTMEVESNAVVKPKGKAAAPRKAPAKKGKSAVVKDDAEDDDDEMLELKDRFAAYRIDSSPDRSEVSAME

Query:  TEAPQVQ-AGKKKEPTKRAPAKKKTTAKSAQIS-DTDDEEFELKETGPPAGKKGGGGRKAAANAKTTKPPAPTKKREPAAKVGQKLITKMLVPAENSGIS
        TE P+VQ A KKKEP+KRA AKKKTTAKSAQIS D+DD +FE+KE  PPA KK GGGRKAAANAKTTK    TKK+EP A++GQKLIT+ML P ENSGIS
Subjt:  TEAPQVQ-AGKKKEPTKRAPAKKKTTAKSAQIS-DTDDEEFELKETGPPAGKKGGGGRKAAANAKTTKPPAPTKKREPAAKVGQKLITKMLVPAENSGIS

Query:  PEKKVRKIRASPSNKKSASILGMAGIEEEEEEDDDNNSDEEGKIMGGGGSASSDTTEESAGFVP-ARGRSQRTNRTQVKYVHSDSDSEPVAEDSDFDDKD
        PEKKVRKIR SP NKKS S+LG    EEEEE ++  N   EGK+M   GSASS+TT+E    VP ARGRSQRTNRTQV+YV SDSDSEPV EDSDFD+ +
Subjt:  PEKKVRKIRASPSNKKSASILGMAGIEEEEEEDDDNNSDEEGKIMGGGGSASSDTTEESAGFVP-ARGRSQRTNRTQVKYVHSDSDSEPVAEDSDFDDKD

Query:  DDFDED
         + DED
Subjt:  DDFDED

A0A6J1F9E0 DNA topoisomerase 2

0.0e+00

88.45

Show/hide

Query:  MVVEKKRPLQNSTAANVDQIPAGPKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYETDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMD
        M VEKKRPLQNS AANVD  PAGPKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYE DKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMD
Subjt:  MVVEKKRPLQNSTAANVDQIPAGPKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYETDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMD

Query:  SLKVVIDAEQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDDEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRQKKYKQVFSDNMGKKGE
        SLKVVIDAEQN ISVFNNGDGVPVE+HQEEKVYVPELIFGHLLTSSNYDD EKKTTGGRNGYGAKLTNIFSTEFVIETADG+R KKYKQVFSDNMGKK E
Subjt:  SLKVVIDAEQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDDEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRQKKYKQVFSDNMGKKGE

Query:  PIITKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASPSTTDPPKRYHVKPNERWEIMV
        PIITKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVD YLKSA+   T+PPKRYH++PNERWEI+V
Subjt:  PIITKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASPSTTDPPKRYHVKPNERWEIMV

Query:  TLSEGQFQQVSFVNGIATIKGGTHVDYITNQIANYVMNVVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSSFGSACELTPDFLKNV
        TLSEGQFQQVSFVNGIATIKGGTHVDYITNQIANYVM VVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSSFGSACELTPDFLKNV
Subjt:  TLSEGQFQQVSFVNGIATIKGGTHVDYITNQIANYVMNVVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSSFGSACELTPDFLKNV

Query:  AAKSGIMDSVLSWVNFKQSKDMKKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQIT
        A KSGIMDSVLSWVNFKQSKD+KKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQIT
Subjt:  AAKSGIMDSVLSWVNFKQSKDMKKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQIT

Query:  ENKEIQYIKQILGLQQGKEYSNSKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWKESLR
        ENKEIQYIKQILGLQQGKEY+N+KALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLL+VPSFLVEFITPIVKATHRNGTVLSFYTMPEYE+WK++LR
Subjt:  ENKEIQYIKQILGLQQGKEYSNSKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWKESLR

Query:  GNANGWSIKYYKGLGTSTSKEGREYFEQLTRHKKDFIWQDDHDGEAIELAFSKKKIEERKNWLRHFEPGTHLDQTGKLIKYSDFVNKELILFSMADNLRS
        GNA+GWSIKYYKGLGTSTSKEGREYFEQL +HKKDFIWQD+HDGEAIELAFSKKKIEERKNWLR FE GTHLDQ+ KLIKYSDFVNKELILFSMAD  RS
Subjt:  GNANGWSIKYYKGLGTSTSKEGREYFEQLTRHKKDFIWQDDHDGEAIELAFSKKKIEERKNWLRHFEPGTHLDQTGKLIKYSDFVNKELILFSMADNLRS

Query:  IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLAGTIIGMAQDFVGSNNLNLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT
        IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLA TIIGMAQDFVGSNN+NLLLPNGQFGTRNHGGKDHASSRYIYTKLSN T
Subjt:  IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLAGTIIGMAQDFVGSNNLNLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT

Query:  RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGGEGIGTGWSTNIPNYNPRDIIRNVRRMLNDETMLPMDPWYRGFSGIIEKTATKDGCSSYTVS
        RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNG EGIGTGWS+ IPNYNPRDIIRNVRRMLN E MLPMDPWYRGFSG IEKTATK+G +SYTVS
Subjt:  RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGGEGIGTGWSTNIPNYNPRDIIRNVRRMLNDETMLPMDPWYRGFSGIIEKTATKDGCSSYTVS

Query:  GIVEEVSDTTLRITELPVRKWTNDYKEFLDSVTRTS-KNDKDKEK-AKDPFIEQADHHSDDKSVSIDVHLTDENMILAMQEGLKKKLKLTTTINTSNMHL
        GI+EEVSDTTLRITELPVR+WTNDYK+FLDSVTR S KNDKDKEK AKDPFIEQADHHSDDK+VSIDVHLT+ENMILAMQEGLKKK KLTTT++TSNMHL
Subjt:  GIVEEVSDTTLRITELPVRKWTNDYKEFLDSVTRTS-KNDKDKEK-AKDPFIEQADHHSDDKSVSIDVHLTDENMILAMQEGLKKKLKLTTTINTSNMHL

Query:  FDANGMIKKYDTPEQILEEFFPLRLEYYEKRKRVLLENLEMELLKLENKARFILAVVNGEIIVSNRRRVDLVHELQAKGFTPFPKKTKSAEPEIAGASDE
        FDANG+IKKYDTPEQILEEFFPLRLE++EKRKR LLENLE ELLKLENK RFILAVVNGEIIVSNRRRVDL HELQ KGFTPFPKKTKS EPE+AGAS+E
Subjt:  FDANGMIKKYDTPEQILEEFFPLRLEYYEKRKRVLLENLEMELLKLENKARFILAVVNGEIIVSNRRRVDLVHELQAKGFTPFPKKTKSAEPEIAGASDE

Query:  TDQTEESPE-VKGDRVSDYEYLLALAIGTLTIEKVQELCNDRDKLKGEVEDLRKATPKSLWLNDLDSLEKELDEMDRNDAHVDEVRKQQRIANNDVKPKI
        TD+ EESPE VKG+RVSDYEYLLALAIGTLTIEKVQELCN+RDK KGEVE+LRKATPKSLWL DLD LEKELDEMDRNDA  DEVRKQQRI NND+KPKI
Subjt:  TDQTEESPE-VKGDRVSDYEYLLALAIGTLTIEKVQELCNDRDKLKGEVEDLRKATPKSLWLNDLDSLEKELDEMDRNDAHVDEVRKQQRIANNDVKPKI

Query:  TRNAPKAPRNSKKTSHSETAVESSMDTTSSSTTMEVESNAVVKPKGKAAAPRKAPAKK-GKSAVVKDDAEDDDDEMLELKDRFAAYRIDSSPDRSEVSAM
        +RNAPKAPRNSKKTS+SET  ES   TTSSSTT EV +N VVKPKGK AAPRKAPAKK GK+AV+ D   DDDDE+LELKDR AAY+++SSP+ SEVSAM
Subjt:  TRNAPKAPRNSKKTSHSETAVESSMDTTSSSTTMEVESNAVVKPKGKAAAPRKAPAKK-GKSAVVKDDAEDDDDEMLELKDRFAAYRIDSSPDRSEVSAM

Query:  ETEAPQVQ-AGKKKEPTKRAPAKKKTTAKSAQIS-DTDDEEFELKETGPPAGKKGGGGRKAAANAKTTKPPAPTKKREPAAKVGQKLITKMLVPAENSGI
        ETE P+VQ A KKKEP+KRA AKKKTTAKSAQIS D+DD +FE+KE  PPA KK GGGRKAAANAKTTK    TKK+EP A++GQKLIT+ML P ENSGI
Subjt:  ETEAPQVQ-AGKKKEPTKRAPAKKKTTAKSAQIS-DTDDEEFELKETGPPAGKKGGGGRKAAANAKTTKPPAPTKKREPAAKVGQKLITKMLVPAENSGI

Query:  SPEKKVRKIRASPSNKKSASILGMAGIEEEEEEDDDNNSDEEGKIMGGGGSASSDTTEESAGFVP-ARGRSQRTNRTQVKYVHSDSDSEPVAEDSDFDDK
        SPEKKVRKIR SP NKKS S+LG    EEEEE ++  N   EGK+M   GSASS+TT+E    VP ARGRSQRTNRTQV+YV SDSDSEPV EDSDFD+ 
Subjt:  SPEKKVRKIRASPSNKKSASILGMAGIEEEEEEDDDNNSDEEGKIMGGGGSASSDTTEESAGFVP-ARGRSQRTNRTQVKYVHSDSDSEPVAEDSDFDDK

Query:  DDDFDED
        + + DED
Subjt:  DDDFDED

A0A6J1J555 DNA topoisomerase 2

0.0e+00

88.25

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Query:  MVVEKKRPLQNSTAANVDQIPAGPKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYETDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMD
        M VE KRPLQNS AANVD  PAGPKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLW+YE DKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMD
Subjt:  MVVEKKRPLQNSTAANVDQIPAGPKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYETDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMD

Query:  SLKVVIDAEQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDDEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRQKKYKQVFSDNMGKKGE
        SLKVVIDAEQNCISVFNNGDGVPVE+HQEEKVYVPELIFGHLLTSSNYDD EKKTTGGRNGYGAKLTNIFSTEFVIETADG+R KKYKQVFSDNMGKK E
Subjt:  SLKVVIDAEQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDDEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRQKKYKQVFSDNMGKKGE

Query:  PIITKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASPSTTDPPKRYHVKPNERWEIMV
        PIITKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVD YLKSA+   T+PPKRYH++PNERWEI+V
Subjt:  PIITKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASPSTTDPPKRYHVKPNERWEIMV

Query:  TLSEGQFQQVSFVNGIATIKGGTHVDYITNQIANYVMNVVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSSFGSACELTPDFLKNV
        TLSEGQFQQVSFVNGIATIKGGTHVDYITNQIANYVM VVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSSFGSACELTPDFLKNV
Subjt:  TLSEGQFQQVSFVNGIATIKGGTHVDYITNQIANYVMNVVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSSFGSACELTPDFLKNV

Query:  AAKSGIMDSVLSWVNFKQSKDMKKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQIT
        A KSGIMDSVLSWVNFKQSKD+KKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQIT
Subjt:  AAKSGIMDSVLSWVNFKQSKDMKKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQIT

Query:  ENKEIQYIKQILGLQQGKEYSNSKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWKESLR
        ENKEIQYIKQILGLQQGKEY+N+KALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLL+VPSFLVEFITPIVKATHRNGTVLSFYTMPEYE+WK++LR
Subjt:  ENKEIQYIKQILGLQQGKEYSNSKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWKESLR

Query:  GNANGWSIKYYKGLGTSTSKEGREYFEQLTRHKKDFIWQDDHDGEAIELAFSKKKIEERKNWLRHFEPGTHLDQTGKLIKYSDFVNKELILFSMADNLRS
        GNA+GWSIKYYKGLGTSTSKEGREYFEQL +HKKDFIWQD+HDGEAIELAFSKKKIEERKNWLR FE GTHLDQ+ KLIKYSDFVNKELILFSMAD  RS
Subjt:  GNANGWSIKYYKGLGTSTSKEGREYFEQLTRHKKDFIWQDDHDGEAIELAFSKKKIEERKNWLRHFEPGTHLDQTGKLIKYSDFVNKELILFSMADNLRS

Query:  IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLAGTIIGMAQDFVGSNNLNLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT
        IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLA TIIGMAQDFVGSNN+NLLLPNGQFGTRNHGGKDHASSRYIYTKLSN T
Subjt:  IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLAGTIIGMAQDFVGSNNLNLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT

Query:  RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGGEGIGTGWSTNIPNYNPRDIIRNVRRMLNDETMLPMDPWYRGFSGIIEKTATKDGCSSYTVS
        RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNG EGIGTGWS+ IPNYNPRDIIRNVRRML+ E MLPMDPWYRGFSG IEKTATK+G +SYTVS
Subjt:  RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGGEGIGTGWSTNIPNYNPRDIIRNVRRMLNDETMLPMDPWYRGFSGIIEKTATKDGCSSYTVS

Query:  GIVEEVSDTTLRITELPVRKWTNDYKEFLDSVTRTS-KNDKDKEK-AKDPFIEQADHHSDDKSVSIDVHLTDENMILAMQEGLKKKLKLTTTINTSNMHL
        GI+EEVSDTTLRITELPVR+WTNDYK+FLDSVTR S KNDKDKEK AKDPFIEQADHHSDDK+VSI+VHLT+ENMILAMQEGLKKK KLTTT++TSNMHL
Subjt:  GIVEEVSDTTLRITELPVRKWTNDYKEFLDSVTRTS-KNDKDKEK-AKDPFIEQADHHSDDKSVSIDVHLTDENMILAMQEGLKKKLKLTTTINTSNMHL

Query:  FDANGMIKKYDTPEQILEEFFPLRLEYYEKRKRVLLENLEMELLKLENKARFILAVVNGEIIVSNRRRVDLVHELQAKGFTPFPKKTKSAEPEIAGASDE
        FDANG+IKKYDTPEQILEEFFPLRLE++EKRKR LLENLE ELLKLENK RFILAVVNGEIIVSNRRRVDL HELQ KGFTPFPKKTKS EPE+AGAS+E
Subjt:  FDANGMIKKYDTPEQILEEFFPLRLEYYEKRKRVLLENLEMELLKLENKARFILAVVNGEIIVSNRRRVDLVHELQAKGFTPFPKKTKSAEPEIAGASDE

Query:  TDQTEESPE-VKGDRVSDYEYLLALAIGTLTIEKVQELCNDRDKLKGEVEDLRKATPKSLWLNDLDSLEKELDEMDRNDAHVDEVRKQQRIANNDVKPKI
        TD+ EESPE VKG+RVSDYEYLLALAIGTLTIEKVQELCN+RDK KGEVE+LRKATPKSLWL DLD LEKELDEMDRNDA  DEVRKQQRI NND+KPKI
Subjt:  TDQTEESPE-VKGDRVSDYEYLLALAIGTLTIEKVQELCNDRDKLKGEVEDLRKATPKSLWLNDLDSLEKELDEMDRNDAHVDEVRKQQRIANNDVKPKI

Query:  TRNAPKAPRNSKKTSHSETAVESSMDTTSSSTTMEVESNAVVKPKGKAAAPRKAPAKKGKSAVVKDDAEDDDDEMLELKDRFAAYRIDSSPDRSEVSAME
        +RNAPKAPRNSKKTS+SET  ES    TSSSTT EV +N VVKPKGK AAPRKAPAKKGK+AV+ DD    DDE+LELKDR AAY+++SSP+ SEVSAME
Subjt:  TRNAPKAPRNSKKTSHSETAVESSMDTTSSSTTMEVESNAVVKPKGKAAAPRKAPAKKGKSAVVKDDAEDDDDEMLELKDRFAAYRIDSSPDRSEVSAME

Query:  TEAPQVQ-AGKKKEPTKRAPAKKKTTAKSAQIS-DTDDEEFELKETGPPAGKKGGGGRKAAANAKTTKPPAPTKKREPAAKVGQKLITKMLVPAENSGIS
        TE P+VQ A KKKEP+KRA AKKKTTAKSAQIS D+DD +FE+KE  PPA KK GGGRKAAANAKTTK    TKK+EP A++GQKLIT+ML P ENSGIS
Subjt:  TEAPQVQ-AGKKKEPTKRAPAKKKTTAKSAQIS-DTDDEEFELKETGPPAGKKGGGGRKAAANAKTTKPPAPTKKREPAAKVGQKLITKMLVPAENSGIS

Query:  PEKKVRKIRASPSNKKSASILGMAGIEEEEEEDDDNNSDEEGKIMGGGGSASSDTTEESAGFVP-ARGRSQRTNRTQVKYVHSDSDSEPVAEDSDFDDKD
        PEKKVRKIR SP NKKS S+LG    EEEEE ++  N   EGK+M   GSASS+TT+E    VP ARGRSQRTNRTQV+YV SDSDSEPV EDSDFD+ +
Subjt:  PEKKVRKIRASPSNKKSASILGMAGIEEEEEEDDDNNSDEEGKIMGGGGSASSDTTEESAGFVP-ARGRSQRTNRTQVKYVHSDSDSEPVAEDSDFDDKD

Query:  DDFDED
         D DED
Subjt:  DDFDED

SwissProt top hits

e value

%identity

Alignment

O24308 DNA topoisomerase 2

0.0e+00

62.34

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Query:  KKRPLQNSTAANVDQIPAGPKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYETDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMDSLKV
        +KRPLQ S AAN+      P KTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYE D+MVHR+V+YVPGLYKIFDEILVNAADNKQRDPSMDSLKV
Subjt:  KKRPLQNSTAANVDQIPAGPKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYETDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMDSLKV

Query:  VIDAEQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDDEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRQKKYKQVFSDNMGKKGEPIIT
         ID E N +SV+NNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDD+ KKTTGGRNGYGAKLTNIFSTEF+IETADG+R KKYKQVFS+NMG K EP+IT
Subjt:  VIDAEQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDDEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRQKKYKQVFSDNMGKKGEPIIT

Query:  KCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASPSTTDPPKRYHVKPNERWEIMVTLSE
        KCK  +NWTKVTFKPDL KF M +LE+DVVALMKKRVLD+AGC GKTVKVELNG  +  KSF+DY DL+LK A  S   P  R H K  +RWEI ++LS+
Subjt:  KCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASPSTTDPPKRYHVKPNERWEIMVTLSE

Query:  GQFQQVSFVNGIATIKGGTHVDYITNQIANYVMNVVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSSFGSACELTPDFLKNVAAKS
        GQFQQVSFVN IATIKGGTHVDYITNQI  Y+MN VNKK K+ANVKAH VK++LWVF+N+LIDNPAFDSQTKETLT RQ+SFGS C++    LK+V  KS
Subjt:  GQFQQVSFVNGIATIKGGTHVDYITNQIANYVMNVVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSSFGSACELTPDFLKNVAAKS

Query:  GIMDSVLSWVNFKQSKDMKKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQITENKE
        GI+D++LSW +FKQSKD+KKTDG KT+++ G  K EDAN AGG+NSEKCTLILTEGDSAKALAMAGL VVGRD YGVFPLRGKLLNVREASSKQI +N+E
Subjt:  GIMDSVLSWVNFKQSKDMKKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQITENKE

Query:  IQYIKQILGLQQGKEYSNSKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWKESLRGNAN
        IQ IK+ILGLQQ KEY+N K+LRYGHLMIM DQDHDGSHIKGLLINFIHSFWPSLLKVPSFLVEF TP+++A+H N T+ SFY+MPEYE+WKE L  +A 
Subjt:  IQYIKQILGLQQGKEYSNSKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWKESLRGNAN

Query:  GWSIKYYKGLGTSTSKEGREYFEQLTRHKKDFIWQDDHDGEAIELAFSKKKIEERKNWLRHFEPGTHLDQTGKLIKYSDFVNKELILFSMADNLRSIPSM
         W IKYYKGLGTST +EGREYF  L RH+KDFIW D+ DG AIELAFSKKK E RK W+R+FEPGT  D   KLI Y DFVNKELILFS AD        
Subjt:  GWSIKYYKGLGTSTSKEGREYFEQLTRHKKDFIWQDDHDGEAIELAFSKKKIEERKNWLRHFEPGTHLDQTGKLIKYSDFVNKELILFSMADNLRSIPSM

Query:  VDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLAGTIIGMAQDFVGSNNLNLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVTRFLF
                   LF SFK+   KE KV+QF GYVSEHSAYHHGEQSLA TIIGMAQDFVGSNN+NLL PNGQFGT N GGKDHAS+RYIYT+LS VTR LF
Subjt:  VDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLAGTIIGMAQDFVGSNNLNLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVTRFLF

Query:  PKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGGEGIGTGWSTNIPNYNPRDIIRNVRRMLNDETMLPMDPWYRGFSGIIEKTATKDGCSSYTVSGIVE
         + DDKLL YLNEDG+SIEP WYMPIIP VLVNG EGIGTGWS+ IPNYNPR+II NVRR+LN E ++PMDPWY+GF G IEK+A + G   Y V+G V 
Subjt:  PKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGGEGIGTGWSTNIPNYNPRDIIRNVRRMLNDETMLPMDPWYRGFSGIIEKTATKDGCSSYTVSGIVE

Query:  EVSDTTLRITELPVRKWTNDYKEFLDSVTRTSKNDKDKEKAKDPFIEQADHHSDDKSVSIDVHLTDENMILAMQEGLKKKLKLTTTINTSNMHLFDANGM
        E+ + T RITELP+RKWT DYK+FL+S+T  + N       KDP IE    + DD  V I++ +  E +   +QEGL KK KLT+TI+TSNMHLFDA G 
Subjt:  EVSDTTLRITELPVRKWTNDYKEFLDSVTRTSKNDKDKEKAKDPFIEQADHHSDDKSVSIDVHLTDENMILAMQEGLKKKLKLTTTINTSNMHLFDANGM

Query:  IKKYDTPEQILEEFFPLRLEYYEKRKRVLLENLEMELLKLENKARFILAVVNGEIIVSNRRRVDLVHELQAKGFTPFPKKTKSAEPEIAGASDETDQTEE
         KK+DTPEQILEEFFPLRL+YYEK K  +L NL   LL L+NK RFIL VVNGEIIVSNR++ +L+ EL+ KGFTP P+K KS +P++AGA+D+  + +E
Subjt:  IKKYDTPEQILEEFFPLRLEYYEKRKRVLLENLEMELLKLENKARFILAVVNGEIIVSNRRRVDLVHELQAKGFTPFPKKTKSAEPEIAGASDETDQTEE

Query:  SPE---------VKGDRVSDYEYLLALAIGTLTIEKVQELCNDRDKLKGEVEDLRKATPKSLWLNDLDSLEKELDEMDRNDAHVDEVRKQQRIAN-NDVK
          E         V+G    DY+ LL+L IGTLT+E VQ+L +++ + + E E L      SLWL DLD  EK+LDE+D   A  D  R  Q     N   
Subjt:  SPE---------VKGDRVSDYEYLLALAIGTLTIEKVQELCNDRDKLKGEVEDLRKATPKSLWLNDLDSLEKELDEMDRNDAHVDEVRKQQRIAN-NDVK

Query:  PKITRNAPKAPRNSKKTSHSETAVESSMDTTSSSTTMEVESNAVVKPKGKAAAPRKAPAKKGKSAVVKDDAEDDDDEMLELKDRFAAYRIDSSPDRSEVS
         K  +  P+  +N+KK          S++  + +++ME+E NAV     +AA P +    KG++A  K+  ++ +D++  L++R AAY I+SS ++S+  
Subjt:  PKITRNAPKAPRNSKKTSHSETAVESSMDTTSSSTTMEVESNAVVKPKGKAAAPRKAPAKKGKSAVVKDDAEDDDDEMLELKDRFAAYRIDSSPDRSEVS

Query:  AMETEAPQVQAGKKKEPTKRAPAKKKTTA------KSAQISDTDDEEFELKETGPPAGKKGGGGRK-AAANAK------TTKPPAPTKKREPAAK--VGQ
        AME+E  Q +A  KK+  KR  AKKK++          +++D DD++ + +E    A     GGRK AA NAK        K PA  KKR    K   GQ
Subjt:  AMETEAPQVQAGKKKEPTKRAPAKKKTTA------KSAQISDTDDEEFELKETGPPAGKKGGGGRK-AAANAK------TTKPPAPTKKREPAAK--VGQ

Query:  KLITKMLVPAENSGISPEKKVRKIRASPSNKKSASILGMAGIEEEEEEDDDNNSDEEGKIMGGGGSASSDTTEESAGFV---PARGRSQRTNRTQVKYVH
        KL+T ML PAE +G SPEKKVRK+R SP NKKS SILG A   ++     D            G ++++  +E+    +   PAR R QR NRTQ+KY  
Subjt:  KLITKMLVPAENSGISPEKKVRKIRASPSNKKSASILGMAGIEEEEEEDDDNNSDEEGKIMGGGGSASSDTTEESAGFV---PARGRSQRTNRTQVKYVH

Query:  SDSDSEPVAEDSDFDDKDDDFDED
        S+S+SE   EDSD D +  DF+ED
Subjt:  SDSDSEPVAEDSDFDDKDDDFDED

O46374 DNA topoisomerase 2-alpha

0.0e+00

46.61

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Query:  MVVEKKRPLQNSTAANVDQIPAGPKK--TIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYETDKMV-HRSVTYVPGLYKIFDEILVNAADNKQRDP
        M V   +P+  +   N  +     KK  +IE +YQKKTQLEHILLRPDTY+GS+E  TQ +WVY+ D  + +R VT+VPGLYKIFDEILVNAADNKQRDP
Subjt:  MVVEKKRPLQNSTAANVDQIPAGPKK--TIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYETDKMV-HRSVTYVPGLYKIFDEILVNAADNKQRDP

Query:  SMDSLKVVIDAEQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDDEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRQKKYKQVFSDNMGK
         M  ++V ID E N IS++NNG G+PV  H+ EK+YVP LIFG LLTSSNYDD+EKK TGGRNGYGAKL NIFST+F +ETA  + +K +KQ + DNMG+
Subjt:  SMDSLKVVIDAEQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDDEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRQKKYKQVFSDNMGK

Query:  KGEPIITKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASPSTTDPPKRYHVKPNERWE
         GE +  K   G+++T +TF PDL+KF M  L+ D+VALM +R  D+AG   K VKV LNG ++PVK F+ YVDLYLK     T +P K  H + N RWE
Subjt:  KGEPIITKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASPSTTDPPKRYHVKPNERWE

Query:  IMVTLSEGQFQQVSFVNGIATIKGGTHVDYITNQIANYVMNVVNKKNK-NANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSSFGSACELTPDF
        + +T+SE  FQQ+SFVN IAT KGG HVDY+ +QI   +++VV KKNK    VKAH VK+++W+F+NALI+NP FDSQTKE +T++  SFGS C+L+  F
Subjt:  IMVTLSEGQFQQVSFVNGIATIKGGTHVDYITNQIANYVMNVVNKKNK-NANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSSFGSACELTPDF

Query:  LKNVAAKSGIMDSVLSWVNFKQSKDM-KKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREAS
        +K  A   GI++S+L+WV FK    + KK    K  +I GI KL+DAN AGG+NS +CTLILTEGDSAK LA++GLGVVGRD YGVFPLRGK+LNVREAS
Subjt:  LKNVAAKSGIMDSVLSWVNFKQSKDM-KKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREAS

Query:  SKQITENKEIQYIKQILGLQQGKEYSNS---KALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKVPSFLVEFITPIVKATHRNGTVLSFYTMPEY
         KQI EN EI  I +I+GLQ  K Y +    K LRYG +MIMTDQD DGSHIKGLLINFIH  WPSLL+   FL EFITPIVK + +N   ++FY++PE+
Subjt:  SKQITENKEIQYIKQILGLQQGKEYSNS---KALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKVPSFLVEFITPIVKATHRNGTVLSFYTMPEY

Query:  ESWKESLRGNANGWSIKYYKGLGTSTSKEGREYFEQLTRHKKDFIWQDDHDGEAIELAFSKKKIEERKNWLRHFE-----------PGTHL-DQTGKLIK
        E WK S   N   W +KYYKGLGTSTSKE +EYF  + RH+  F +    D  AI LAFSKK+I++RK WL HF            P  +L  QT   + 
Subjt:  ESWKESLRGNANGWSIKYYKGLGTSTSKEGREYFEQLTRHKKDFIWQDDHDGEAIELAFSKKKIEERKNWLRHFE-----------PGTHL-DQTGKLIK

Query:  YSDFVNKELILFSMADNLRSIPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLAGTIIGMAQDFVGSNNLNLLLPNGQFGTRN
        Y+DF+NKELILFS +DN RSIPSMVDGLKPGQRK+LF  FKRN  +E KV+Q +G V+E S+YHHGE SL  TII +AQ+FVGSNNLNLL P GQFGTR 
Subjt:  YSDFVNKELILFSMADNLRSIPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLAGTIIGMAQDFVGSNNLNLLLPNGQFGTRN

Query:  HGGKDHASSRYIYTKLSNVTRFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGGEGIGTGWSTNIPNYNPRDIIRNVRRMLNDETMLPMDPWYRG
        HGGKD AS RYI+T LS + R LFP  DD  L +L +D Q +EP WY+PIIP VL+NG EGIGTGWS  IPN++ R+++ N+R +++ E  LPM P Y+ 
Subjt:  HGGKDHASSRYIYTKLSNVTRFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGGEGIGTGWSTNIPNYNPRDIIRNVRRMLNDETMLPMDPWYRG

Query:  FSGIIEKTATKDGCSSYTVSGIVEEVSDTTLRITELPVRKWTNDYKEFLDSVTRTSKNDKDKEKAKDPFIEQADHHSDDKSVSIDVHLTDENMILAMQEG
        F G IE+ A     + Y +SG V  ++ TT+ I+ELP+R WT  YKE    V     N  +K     P I     +  D +V   V +T+E +  A + G
Subjt:  FSGIIEKTATKDGCSSYTVSGIVEEVSDTTLRITELPVRKWTNDYKEFLDSVTRTSKNDKDKEKAKDPFIEQADHHSDDKSVSIDVHLTDENMILAMQEG

Query:  LKKKLKLTTTINTSNMHLFDANGMIKKYDTPEQILEEFFPLRLEYYEKRKRVLLENLEMELLKLENKARFILAVVNGEIIVSNRRRVDLVHELQAKGFTP
        L K  KL T++  ++M LFD  G +KKYDT   IL +FF LRL+YY  RK  LL  L  E  KL N+ARFIL  ++G+II+ N+ + +L+  L  +G+  
Subjt:  LKKKLKLTTTINTSNMHLFDANGMIKKYDTPEQILEEFFPLRLEYYEKRKRVLLENLEMELLKLENKARFILAVVNGEIIVSNRRRVDLVHELQAKGFTP

Query:  FPKKT-KSAEPEIAGASDETDQTEESPEVKGDRVSD----YEYLLALAIGTLTIEKVQELCNDRDKLKGEVEDLRKATPKSLWLNDLDSLEKELDEMDRN
         P K  K A+ ++    +  +   E    K D V+D    + YLL + +  LT EK  ELC  R++ + E+E L++ +P  LW  DL +  +EL+ ++  
Subjt:  FPKKT-KSAEPEIAGASDETDQTEESPEVKGDRVSD----YEYLLALAIGTLTIEKVQELCNDRDKLKGEVEDLRKATPKSLWLNDLDSLEKELDEMDRN

Query:  DAHVDEVRKQQRIANNDVKPKITRNAPKAPRNSKKTSHSETAVESSMDTTSSSTTMEVESNAVVKPKGKAAAPRKAPAKKG-----------KSAVVKDD
        +   +++    +      K K T+ A   P    K       VE           M+ E+   +K K K+     +P + G           K    +  
Subjt:  DAHVDEVRKQQRIANNDVKPKITRNAPKAPRNSKKTSHSETAVESSMDTTSSSTTMEVESNAVVKPKGKAAAPRKAPAKKG-----------KSAVVKDD

Query:  AEDDDDEMLELKD-RFAAYRIDSSPDRSEVSAMETEAPQVQAGKKKEPTKRAPAKKKTTA---KSAQISDTD----DEEF-------ELKETGPPAGKKG
         +      L  K  + A  R   S   S++S+ E+        ++KEP +RA AK K T         SD D    DE+F       +  ET P    K 
Subjt:  AEDDDDEMLELKD-RFAAYRIDSSPDRSEVSAMETEAPQVQAGKKKEPTKRAPAKKKTTA---KSAQISDTD----DEEF-------ELKETGPPAGKKG

Query:  GGGRKA--------AANAKTTKPPAPTKKREPAAKVGQKLITKMLVPAENSGISPEKKVRKIRASPSNKKSASILGMAGIEEEEEEDDD
           +K+        A +AK   PP+P+    P A      +T+ + P     ++ +K   K ++S S   +       G +++ + D D
Subjt:  GGGRKA--------AANAKTTKPPAPTKKREPAAKVGQKLITKMLVPAENSGISPEKKVRKIRASPSNKKSASILGMAGIEEEEEEDDD

P08096 DNA topoisomerase 2

0.0e+00

46.45

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Query:  KKRPLQNSTAANVDQIP-----AGPKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVY--ETDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDP
        ++  L + TA+  +QIP           +   YQ+ T  EH+L RPDTY+GSIE  T  +WV+  E +K+ +++VTYVPGLYKIFDEI+VNAADNK RDP
Subjt:  KKRPLQNSTAANVDQIP-----AGPKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVY--ETDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDP

Query:  SMDSLKVVIDAEQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDDEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRQKKYKQVFSDNMGK
        +M++LKV +D E N IS++NNG G+P+EIH +EK+Y+PELIFG+LLTSSNYDD++KK TGGRNGYGAKL NIFSTEFV+ETAD +R KKYKQ + DNM +
Subjt:  SMDSLKVVIDAEQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDDEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRQKKYKQVFSDNMGK

Query:  KGEPIITKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASPSTTDPPKRYHVKPNERWE
        K EP+IT  K+ D +TK+TFKPDLAKF M  ++DD+V+++K+R+ D+AG + +T KV LN +R+ +  F+ YV++YL S +    +PP+  +   N+RW+
Subjt:  KGEPIITKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASPSTTDPPKRYHVKPNERWE

Query:  IMVTLSEGQFQQVSFVNGIATIKGGTHVDYITNQIANYVMNVVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSSFGSACELTPDFL
        +   +S+GQF+QVSFVN I+TI+GGTHV+Y+ N+I + +  VV K+NK A VKA  +K+Y+ VF+N  I+NP+FDSQTKETLT + S+FGS C L+  FL
Subjt:  IMVTLSEGQFQQVSFVNGIATIKGGTHVDYITNQIANYVMNVVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSSFGSACELTPDFL

Query:  KNVAAKSGIMDSVLSWVNFKQSKDMKKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSK
        K +  KS +++ VL +   K  + + K DG    +I+G+ KLEDAN AG K S KC LILTEGDSAK+LA++GL VVGRD+YGVFPLRGKLLNVREAS  
Subjt:  KNVAAKSGIMDSVLSWVNFKQSKDMKKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSK

Query:  QITENKEIQYIKQILGLQQGKEYSNSKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWKE
        QI  NKEIQ IK+I+G    K Y++ K LRYGHLMIMTDQDHDGSHIKGL+IN++ S +PSLL++P FL++FITPI+K T R   V +FYT+PEYE WKE
Subjt:  QITENKEIQYIKQILGLQQGKEYSNSKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWKE

Query:  SLRGNANGWSIKYYKGLGTSTSKEGREYFEQLTRHKKDFIWQDDHDGEAIELAFSKKKIEERKNWLRHFEPGTHLDQTGKLIKYSDFVNKELILFSMADN
        +   N  GW IKYYKGLGTS   + + YF  L RH K F    + D E IE+AF+KKK + RK WLR + PG ++D T   I   DF+N+ELI FSMADN
Subjt:  SLRGNANGWSIKYYKGLGTSTSKEGREYFEQLTRHKKDFIWQDDHDGEAIELAFSKKKIEERKNWLRHFEPGTHLDQTGKLIKYSDFVNKELILFSMADN

Query:  LRSIPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLAGTIIGMAQDFVGSNNLNLLLPNGQFGTRNHGGKDHASSRYIYTKLS
        +RSIPS+VDGLKPGQRK+++  FKRN + E KVS+ +GYV+  +AYHHGE S+  TI+ +AQ+FVGSNN+NLL+PNGQFGTR+ GGK+ ++SRY+ T LS
Subjt:  LRSIPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLAGTIIGMAQDFVGSNNLNLLLPNGQFGTRNHGGKDHASSRYIYTKLS

Query:  NVTRFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGGEGIGTGWSTNIPNYNPRDIIRNVRRMLNDETMLPMDPWYRGFSGIIEKTATKDGCSSY
         + R LF  +DD+LLNY N++GQ IEP +Y+PI+P VLVNG EGIGTGWST IPNYNP+DI  N+R MLN E +  M PWYRGF G I K A       Y
Subjt:  NVTRFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGGEGIGTGWSTNIPNYNPRDIIRNVRRMLNDETMLPMDPWYRGFSGIIEKTATKDGCSSY

Query:  TVSGIVEEVSDTTLRITELPVRKWTNDYKEFLDS-VTRTSKNDKDKEKAKDPFIEQADHHSDDKSVSIDVHLTDENMILAMQEGLKKKLKLTTTINTSNM
         +SGI+ ++ +  + ITELP+R WT D KE+L++ +  T K  K        FI   + H  + +V  +V LT+  M  A+ E L+ K KL+ T  TSNM
Subjt:  TVSGIVEEVSDTTLRITELPVRKWTNDYKEFLDS-VTRTSKNDKDKEKAKDPFIEQADHHSDDKSVSIDVHLTDENMILAMQEGLKKKLKLTTTINTSNM

Query:  HLFDANGMIKKYDTPEQILEEFFPLRLEYYEKRKRVLLENLEMELLKLENKARFILAVVNGEIIVSNRRRVDLVHELQAKGFTPF--PKKTKSAEPEIAG
          FDA+G IKKYD+ E IL EF+ +RL  Y++RK  ++  LE    +  N+ARFI  ++ GE++VS +++ DL+ EL+ K F P   PKK    + E+  
Subjt:  HLFDANGMIKKYDTPEQILEEFFPLRLEYYEKRKRVLLENLEMELLKLENKARFILAVVNGEIIVSNRRRVDLVHELQAKGFTPF--PKKTKSAEPEIAG

Query:  ASDETDQTEESPEVKGDRVSD-YEYLLALAIGTLTIEKVQELCNDRDKLKGEVEDLRKATPKSLWLNDLDSLE----KELDEMDRNDAHVDEVRKQQRIA
        A  E    E+S +V  D  SD Y YLL++ + +LT E+  EL   +D++  E++ L K TPK LWL+DLD+ E    K +D++ R +   +E   +  + 
Subjt:  ASDETDQTEESPEVKGDRVSD-YEYLLALAIGTLTIEKVQELCNDRDKLKGEVEDLRKATPKSLWLNDLDSLE----KELDEMDRNDAHVDEVRKQQRIA

Query:  NNDVKPKITRNAPKAPRNSKKTSHSETAVESSMDTTSSSTTMEVESNAVVKPKGKAAAPRKAPAKKGKSAVVKDDAEDDDDEMLELKDRFAAYRIDSSP-
            KP+      + PR +   S S TAV+    + S  +T   +   +++      A  K P K     +VK    +D+   L +++     RI  SP 
Subjt:  NNDVKPKITRNAPKAPRNSKKTSHSETAVESSMDTTSSSTTMEVESNAVVKPKGKAAAPRKAPAKKGKSAVVKDDAEDDDDEMLELKDRFAAYRIDSSP-

Query:  -DRSEVSAMETEAPQVQAGKKKEPTKRAPAKKKTTAKSAQISDTDDEEFELKETGPPAGKKGGGGRKAAANAKTTKPPAPTKKREPAAKVGQKLITKMLV
         D S+            +GK +              K +Q  D++D   + K     A    G GR      KT KP A T     ++     L+   L 
Subjt:  -DRSEVSAMETEAPQVQAGKKKEPTKRAPAKKKTTAKSAQISDTDDEEFELKETGPPAGKKGGGGRKAAANAKTTKPPAPTKKREPAAKVGQKLITKMLV

Query:  PAENSGISPEKKVRKIRASPSNK-KSASILGMAGIEEEEEEDDDNNSDEEGKIMGGGGSASSDTTEESAGFVPARGRSQRTNRTQVK---YVHSDSDS--
        P+          +   +AS  NK K AS      ++++  EDDD++    G       S+++    E +   P R R  R     VK   YV    DS  
Subjt:  PAENSGISPEKKVRKIRASPSNK-KSASILGMAGIEEEEEEDDDNNSDEEGKIMGGGGSASSDTTEESAGFVPARGRSQRTNRTQVK---YVHSDSDS--

Query:  EPVAEDSDF----DDKDDDFDE
        EP  +D  F    D+  DD+DE
Subjt:  EPVAEDSDF----DDKDDDFDE

P30182 DNA topoisomerase 2

0.0e+00

62.94

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Query:  KRPLQNSTAANVDQIPAGPK-----KTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYETDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMD
        K PLQNS AANV + PA  +     KTIEEMYQKK+QLEHILLRPDTY+GSIEKHTQ LWVYE D+MV R VTYVPGLYKIFDEILVNAADNKQRD  MD
Subjt:  KRPLQNSTAANVDQIPAGPK-----KTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYETDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMD

Query:  SLKVVIDAEQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDDEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRQKKYKQVFSDNMGKKGE
        S++VVID EQN ISV N+G GVPVEIHQEE +YVPE+IFGHLLTSSNYDD+ KKTTGGRNGYGAKLTNIFSTEF+IETADGKR KKYKQVF +NMGKK E
Subjt:  SLKVVIDAEQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDDEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRQKKYKQVFSDNMGKKGE

Query:  PIITKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASPS-TTDPPKRYHVKPNERWEIM
        P+ITKC + +NWTKVTFKPDL KFNMT LEDDVVALM KRV D+AGCLGK+VKVELNG+++PVKSF DYVDLYL +A+ S T DP  R   K N+RWE+ 
Subjt:  PIITKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASPS-TTDPPKRYHVKPNERWEIM

Query:  VTLSEGQFQQVSFVNGIATIKGGTHVDYITNQIANYVMNVVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSSFGSACELTPDFLKN
        V+LSEGQFQQVSFVN IATIKGGTHVDY+T+QI N+++  VNKKNKNANVKAHNVK++LWVF+NALIDNPAFDSQTKETLT+RQSSFGS CEL+ DFLK 
Subjt:  VTLSEGQFQQVSFVNGIATIKGGTHVDYITNQIANYVMNVVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSSFGSACELTPDFLKN

Query:  VAAKSGIMDSVLSWVNFKQSKDMKKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQI
        V  KSG+++++LSW +FKQ+KD+KK+DGAKT ++  +EKL+DA  AGGKNS  CTLILTEGDSAK+LA+AG  V+G ++ GVFPLRGKLLNVREAS+ QI
Subjt:  VAAKSGIMDSVLSWVNFKQSKDMKKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQI

Query:  TENKEIQYIKQILGLQQGKEYSNSKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKVPSFLVEFITPIVKATHRNGT--VLSFYTMPEYESWKE
        T NKEI+ +K+ILGL+Q  +Y N  +LRYG +MIMTDQDHDGSHIKGLLINFIHSFWPSLL+VPSFLVEFITPIVKAT R GT  VLSFY+MPEYE WKE
Subjt:  TENKEIQYIKQILGLQQGKEYSNSKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKVPSFLVEFITPIVKATHRNGT--VLSFYTMPEYESWKE

Query:  SLRGNANGWSIKYYKGLGTSTSKEGREYFEQLTRHKKDFIWQDDHDGEAIELAFSKKKIEERKNWLRHFEPGTHLDQTGKLIKYSDFVNKELILFSMADN
        SL+GNA GW IKYYKGLGTST++EG+EYF  L  HKKDF+W+D+ DGEAIELAFSKKKIE RKNWL  + PG HLDQ    + YSDFVNKELILFSMAD 
Subjt:  SLRGNANGWSIKYYKGLGTSTSKEGREYFEQLTRHKKDFIWQDDHDGEAIELAFSKKKIEERKNWLRHFEPGTHLDQTGKLIKYSDFVNKELILFSMADN

Query:  LRSIPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLAGTIIGMAQDFVGSNNLNLLLPNGQFGTRNHGGKDHASSRYIYTKLS
         RSIPSMVDGLKPGQRKILF +FK+   KE KV+Q  GYVS  SAYHHGEQSLA  IIGMAQD+VGSNN+NLLLPNGQFGTR  GGKD AS+RYI+TKLS
Subjt:  LRSIPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLAGTIIGMAQDFVGSNNLNLLLPNGQFGTRNHGGKDHASSRYIYTKLS

Query:  NVTRFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGGEGIGTGWSTNIPNYNPRDIIRNVRRMLNDETMLPMDPWYRGFSGIIEKTATKDGCSSY
         VTR LFPKDDD LL+YLNEDGQ IEPTWYMPIIPTVLVNG EGIGTGWST IPNYNPR+I+ NVRR+LN E+M+PMDPWYRGF G IEKTA+K+G  +Y
Subjt:  NVTRFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGGEGIGTGWSTNIPNYNPRDIIRNVRRMLNDETMLPMDPWYRGFSGIIEKTATKDGCSSY

Query:  TVSGIVEEVSDTTLRITELPVRKWTNDYKEFLDSVTRTSKNDKDKEKAKDPFIEQADHHSDDKSVSIDVHLTDENMILAMQEGLKKKLKLTTTINTSNMH
        T++G+ EEV +TT+RITELP+R+W +DYK FL S+    K D        PF +    ++D+KSV  D+ L++ENM+ A QEG  KK KLTTTI TSNMH
Subjt:  TVSGIVEEVSDTTLRITELPVRKWTNDYKEFLDSVTRTSKNDKDKEKAKDPFIEQADHHSDDKSVSIDVHLTDENMILAMQEGLKKKLKLTTTINTSNMH

Query:  LFDANGMIKKYDTPEQILEEFFPLRLEYYEKRKRVLLENLEMELLKLENKARFILAVVNGEIIVSNRRRVDLVHELQAKGFTPFPKKTKSAEPEIAGASD
        LFD  G+IKKY TPEQILEEFF LR EYYEKRK  +++N+E+ELLKLENKARFILAV++GEIIV+ R++ D+V +L+ KGFTPFP+K +S E  IAGA D
Subjt:  LFDANGMIKKYDTPEQILEEFFPLRLEYYEKRKRVLLENLEMELLKLENKARFILAVVNGEIIVSNRRRVDLVHELQAKGFTPFPKKTKSAEPEIAGASD

Query:  ETDQTEESPEVKGDRV--------SDYEYLLALAIGTLTIEKVQELCNDRDKLKGEVEDLRKATPKSLWLNDLDSLEKELDEMDRNDAHVD---EVRKQQ
        + D  EE  E+  D          S+Y+YLLA+AI +LTIEKV+EL  DRDK+   V D++K TPKSLWL+DL+SL+KEL+++D  DA V    E  +++
Subjt:  ETDQTEESPEVKGDRV--------SDYEYLLALAIGTLTIEKVQELCNDRDKLKGEVEDLRKATPKSLWLNDLDSLEKELDEMDRNDAHVD---EVRKQQ

Query:  RIANNDVKPKITRNAPKAP---RNSKKTSHSETAVESSMDTTSSSTTMEVESNA--VVKPKGKAAAPRKAPAKKGKSAVVKDDAEDDDDEMLELKDRFAA
          A +    K+ R APK P   + +KK S SET       T +S + M+ ++N   VVKPK +  A +K  A + ++      A D D+ + E+      
Subjt:  RIANNDVKPKITRNAPKAP---RNSKKTSHSETAVESSMDTTSSSTTMEVESNA--VVKPKGKAAAPRKAPAKKGKSAVVKDDAEDDDDEMLELKDRFAA

Query:  YRIDSSPDRSEVSAMETEAPQVQAGKKKEPTKRAPAKKKTTAKSAQISDTDDEEFELKETGPPAGKKGGGGRKAAANAKTTKPPAPTKKREPAAKVGQKL
                 +     E E   +     +     APA    TA++++    DD++ ++     P  K   GGRK AA  K  KPPA  +KR      G++ 
Subjt:  YRIDSSPDRSEVSAMETEAPQVQAGKKKEPTKRAPAKKKTTAKSAQISDTDDEEFELKETGPPAGKKGGGGRKAAANAKTTKPPAPTKKREPAAKVGQKL

Query:  ITKMLVPAENSGISPEKKVRKIRASPSNKKSASILGMAGIEEEEEEDDDNNSDEEGKIMGGGGSASSDTTEESAGFVPARGRSQRTNRTQVKYVHSDSDS
        +    V A   G+SPEKKVRK+R+SP NKKS+S++      +EEE  ++               A + ++E+S G V A  R QR NR ++ YV SDS+S
Subjt:  ITKMLVPAENSGISPEKKVRKIRASPSNKKSASILGMAGIEEEEEEDDDNNSDEEGKIMGGGGSASSDTTEESAGFVPARGRSQRTNRTQVKYVHSDSDS

Query:  EPVAEDSDFDDKDDDFDED
        E  A DS+FDD +DD D++
Subjt:  EPVAEDSDFDDKDDDFDED

Q55BP5 Probable DNA topoisomerase 2

0.0e+00

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Query:  KTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYETDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMDSLKVVIDAEQNCISVFNNGDGVPVE
        K+IEE+YQKK  L+ ILLRPDTY+GS E+  + LWV+E  +MVHR V++VPG+YKIFDEILVNAADNKQR+ +M  +KVVID E+  ISV N+G G+P++
Subjt:  KTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYETDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMDSLKVVIDAEQNCISVFNNGDGVPVE

Query:  IHQEEKVYVPELIFGHLLTSSNYDDDEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRQKKYKQVFSDNMGKKGEPIITKCKEGDNWTKVTFKPDLAKFN
        +H E K+Y+PELIFG+LLTSS+YDD EK+ TGGRNG+GAKL NIFST+F++E AD K +K YKQ F++NM  K +P IT  +   ++TK+TF P+L +F 
Subjt:  IHQEEKVYVPELIFGHLLTSSNYDDDEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRQKKYKQVFSDNMGKKGEPIITKCKEGDNWTKVTFKPDLAKFN

Query:  MTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASPSTTDPPKRYHVKPNERWEIMVTLS-EGQFQQVSFVNGIATIKGGTH
        M   +DD+VAL+ KRV D+AGC   T+KV LN + + ++SF+ Y++LY     P   + PK Y+ K ++RWE+ VTLS E QF QVSFVN I T+KGGTH
Subjt:  MTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASPSTTDPPKRYHVKPNERWEIMVTLS-EGQFQQVSFVNGIATIKGGTH

Query:  VDYITNQIANYVMNVVNKKNK-NANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSSFGSACELTPDFLKNVA-AKSGIMDSVLSWVNFKQSKDM
        V +  + I   +   VNKKNK +A++K   +K++L VF+N LI+NP FDSQTKETLT + SSFGS CE +  F+K V  +KSGI+ S+L +  FK    +
Subjt:  VDYITNQIANYVMNVVNKKNK-NANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSSFGSACELTPDFLKNVA-AKSGIMDSVLSWVNFKQSKDM

Query:  KK--TDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQITENKEIQYIKQILGLQQGKEY
        K+  + G K  K+S I KL+DAN AGG  SE CTLILTEGDSAK+LA AG+ VVG+D YG FPL+GKLLNVR+ S+K +  N EI  I  ILGL+ GK Y
Subjt:  KK--TDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQITENKEIQYIKQILGLQQGKEY

Query:  SNSKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWKESLRGNANGWSIKYYKGLGTSTSK
             LRYGHLMIMTDQDHDGSHIKGL+IN +H FWP+LL++P FLVEFITPIVK    N   +SFYTMPE+  W+E+   N  GW +KYYKGLGTST  
Subjt:  SNSKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWKESLRGNANGWSIKYYKGLGTSTSK

Query:  EGREYFEQLTRHKKDFIWQDDHDGEAIELAFSKKKIEERKNWLRHFEPGTHLDQTG-KLIKYSDFVNKELILFSMADNLRSIPSMVDGLKPGQRKILFCS
        EG+EYF  L RHK DF W D+   + IELAFSK + ++RK W+     GT L+Q G K + YSDF+NKEL+LFS+AD  RSIP++VDGLK   RK L+  
Subjt:  EGREYFEQLTRHKKDFIWQDDHDGEAIELAFSKKKIEERKNWLRHFEPGTHLDQTG-KLIKYSDFVNKELILFSMADNLRSIPSMVDGLKPGQRKILFCS

Query:  FKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLAGTIIGMAQDFVGSNNLNLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVTRFLFPKDDDKLLNYLNEDG
        FKRN  KE KV+Q  GYVSEHSAYHHGE SL  TI+GMAQ+FVGSNN+NLL P G +GTR  GGKD +S+RYI+T+L+++ R ++  DDD +L+ + +DG
Subjt:  FKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLAGTIIGMAQDFVGSNNLNLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVTRFLFPKDDDKLLNYLNEDG

Query:  QSIEPTWYMPIIPTVLVNGGEGIGTGWSTNIPNYNPRDIIRNVRRMLNDETMLPMDPWYRGFSGIIE-KTATKDGCSSYTVSGIVEEVSDTTLRITELPV
        + ++P +Y+P+IP +LVNG  GIGTGWS+ IPNYNPRD+I+N+R  ++ + + P+ PWYRGF G IE    +K     Y   GI +++SD    ITELP+
Subjt:  QSIEPTWYMPIIPTVLVNGGEGIGTGWSTNIPNYNPRDIIRNVRRMLNDETMLPMDPWYRGFSGIIE-KTATKDGCSSYTVSGIVEEVSDTTLRITELPV

Query:  RKWTNDYKEFLDSV-----TRTSKNDKDKE-------KAKDPFIEQADHHSDDK----------------SVSIDVHLTDENMILAMQEGLKKKLKLTTT
          WT DY+E LD +      +  K +K+K+       KAK    +++    DD                 S    +H   + +    +  ++K  KL +T
Subjt:  RKWTNDYKEFLDSV-----TRTSKNDKDKE-------KAKDPFIEQADHHSDDK----------------SVSIDVHLTDENMILAMQEGLKKKLKLTTT

Query:  INTSNMHLFDANGMIKKYDTPEQILEEFFPLRLEYYEKRKRVLLENLEMELLKLENKARFILAVVNGEIIVSNRRRVDLVHELQAKGFTPFPKK--TKSA
        IN +NM +FD  G I+++ T   + E FFPLR+++Y+ RK  L E L  E  +L NKARFILAVVN E+++SN ++VDL+++L+   F     K   KSA
Subjt:  INTSNMHLFDANGMIKKYDTPEQILEEFFPLRLEYYEKRKRVLLENLEMELLKLENKARFILAVVNGEIIVSNRRRVDLVHELQAKGFTPFPKK--TKSA

Query:  EPEI---AGASDETDQTEESPEVK-------GDRVSDYEYLLALAIGTLTIEKVQELCNDRDKLKGEVEDLRKATPKSLWLNDLDSLEKELDEMDRNDA-
          +I     A DE D    S E K        D    Y+YLL+L + +LT+E+V++L  +RD  K E + L     + ++  DLD+LEK LD+ D  D  
Subjt:  EPEI---AGASDETDQTEESPEVK-------GDRVSDYEYLLALAIGTLTIEKVQELCNDRDKLKGEVEDLRKATPKSLWLNDLDSLEKELDEMDRNDA-

Query:  ---HVDEVRKQQRI----ANNDVKPKITRNAPKAPRNS--KKTSHSETAVESSM---------DTTSSSTTMEVESNAVVKPKGKAAAPRK-APAKKGKS
             + ++K+ +         +  K+ ++  +AP     K T    T  +S++         DTTS+ST+    SN        A   +K  PA K  +
Subjt:  ---HVDEVRKQQRI----ANNDVKPKITRNAPKAPRNS--KKTSHSETAVESSM---------DTTSSSTTMEVESNAVVKPKGKAAAPRK-APAKKGKS

Query:  AVVKD-DAEDDDDEMLELKDRFAAYRIDSSPDRSEVSAMETEAPQVQAGKKKEPTKRAPA----------KKKTTAKSAQISD--TDDEEFELKETGP
         V  D D++ DDD ++  K +    +     + S+ S  E++    Q    + P KR+ A          KK TT+KS  I D  +DDE  +     P
Subjt:  AVVKD-DAEDDDDEMLELKDRFAAYRIDSSPDRSEVSAMETEAPQVQAGKKKEPTKRAPA----------KKKTTAKSAQISD--TDDEEFELKETGP

Arabidopsis top hits

e value

%identity

Alignment

AT3G10270.1 DNA GYRASE B1

2.5e-26

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Query:  GLYKIFDEILVNAADNKQRDPSMDSLKVVIDAEQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDDEK--KTTGGRNGYGAKLTNIFSTEF
        GL+ +  EIL NA D  Q       + VV+ ++ + +S+ +NG G+P ++H        E +   L     +         +GG +G G  + N  S   
Subjt:  GLYKIFDEILVNAADNKQRDPSMDSLKVVIDAEQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDDEK--KTTGGRNGYGAKLTNIFSTEF

Query:  -VIETADGKR-QKKYKQVFSDNMGKKGEPIIT-KC------KEGDNWTKVTFKPDLAKFNMT-HLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVK
         VI   DG   Q+KY          +G+P+ T  C        G   T + F PD   F      + + +A   + +  L   +  ++K E +     V 
Subjt:  -VIETADGKR-QKKYKQVFSDNMGKKGEPIIT-KC------KEGDNWTKVTFKPDLAKFNMT-HLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVK

Query:  SFQDYVDLYLKSASPSTTDPPKRYHVKPNERWEIMVTLSEGQFQ---------QVSFVNGIATIKGGTHVDYITNQIANYVMNVVNKKNKNANVKAHNVK
        S   Y     +  S   TD  K  H     R EI  +  +   Q          + + N I TI GGTH++ +   +    +N + KK K   VK + + 
Subjt:  SFQDYVDLYLKSASPSTTDPPKRYHVKPNERWEIMVTLSEGQFQ---------QVSFVNGIATIKGGTHVDYITNQIANYVMNVVNKKNKNANVKAHNVK

Query:  SYLWV-------------------------------------FINALIDNPAFDSQTKETL---TIR-------QSSFGSACELTPDFLKNVAAKSGIMD
        S  W+                                      ++  + NP F+ QTK  L    +R       Q       EL PD L+++ +KS  ++
Subjt:  SYLWV-------------------------------------FINALIDNPAFDSQTKETL---TIR-------QSSFGSACELTPDFLKNVAAKSGIMD

Query:  SVLSWVNFKQSKDMKKTDGA-KTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQITENKEIQY
        +  + +  K+++++ ++    K+  + G  KL D +      SE   + + EGDSA   A  G     R F  + PLRGK+LN+       + +N+EIQ 
Subjt:  SVLSWVNFKQSKDMKKTDGA-KTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQITENKEIQY

Query:  IKQILGLQQGKEYSNSKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWKESLRGNANGWS
        +   LGL    E  N + LRY  ++I+TD D DG+HI+ LL+ F   +  +L       V  + P+ K   R       Y     +    S  GNA+ ++
Subjt:  IKQILGLQQGKEYSNSKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWKESLRGNANGWS

Query:  IKYYKGLG
        I+ +KGLG
Subjt:  IKYYKGLG

AT3G23890.1 topoisomerase II

0.0e+00

62.94

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Query:  KRPLQNSTAANVDQIPAGPK-----KTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYETDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMD
        K PLQNS AANV + PA  +     KTIEEMYQKK+QLEHILLRPDTY+GSIEKHTQ LWVYE D+MV R VTYVPGLYKIFDEILVNAADNKQRD  MD
Subjt:  KRPLQNSTAANVDQIPAGPK-----KTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYETDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMD

Query:  SLKVVIDAEQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDDEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRQKKYKQVFSDNMGKKGE
        S++VVID EQN ISV N+G GVPVEIHQEE +YVPE+IFGHLLTSSNYDD+ KKTTGGRNGYGAKLTNIFSTEF+IETADGKR KKYKQVF +NMGKK E
Subjt:  SLKVVIDAEQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDDEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRQKKYKQVFSDNMGKKGE

Query:  PIITKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASPS-TTDPPKRYHVKPNERWEIM
        P+ITKC + +NWTKVTFKPDL KFNMT LEDDVVALM KRV D+AGCLGK+VKVELNG+++PVKSF DYVDLYL +A+ S T DP  R   K N+RWE+ 
Subjt:  PIITKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASPS-TTDPPKRYHVKPNERWEIM

Query:  VTLSEGQFQQVSFVNGIATIKGGTHVDYITNQIANYVMNVVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSSFGSACELTPDFLKN
        V+LSEGQFQQVSFVN IATIKGGTHVDY+T+QI N+++  VNKKNKNANVKAHNVK++LWVF+NALIDNPAFDSQTKETLT+RQSSFGS CEL+ DFLK 
Subjt:  VTLSEGQFQQVSFVNGIATIKGGTHVDYITNQIANYVMNVVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSSFGSACELTPDFLKN

Query:  VAAKSGIMDSVLSWVNFKQSKDMKKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQI
        V  KSG+++++LSW +FKQ+KD+KK+DGAKT ++  +EKL+DA  AGGKNS  CTLILTEGDSAK+LA+AG  V+G ++ GVFPLRGKLLNVREAS+ QI
Subjt:  VAAKSGIMDSVLSWVNFKQSKDMKKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQI

Query:  TENKEIQYIKQILGLQQGKEYSNSKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKVPSFLVEFITPIVKATHRNGT--VLSFYTMPEYESWKE
        T NKEI+ +K+ILGL+Q  +Y N  +LRYG +MIMTDQDHDGSHIKGLLINFIHSFWPSLL+VPSFLVEFITPIVKAT R GT  VLSFY+MPEYE WKE
Subjt:  TENKEIQYIKQILGLQQGKEYSNSKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKVPSFLVEFITPIVKATHRNGT--VLSFYTMPEYESWKE

Query:  SLRGNANGWSIKYYKGLGTSTSKEGREYFEQLTRHKKDFIWQDDHDGEAIELAFSKKKIEERKNWLRHFEPGTHLDQTGKLIKYSDFVNKELILFSMADN
        SL+GNA GW IKYYKGLGTST++EG+EYF  L  HKKDF+W+D+ DGEAIELAFSKKKIE RKNWL  + PG HLDQ    + YSDFVNKELILFSMAD 
Subjt:  SLRGNANGWSIKYYKGLGTSTSKEGREYFEQLTRHKKDFIWQDDHDGEAIELAFSKKKIEERKNWLRHFEPGTHLDQTGKLIKYSDFVNKELILFSMADN

Query:  LRSIPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLAGTIIGMAQDFVGSNNLNLLLPNGQFGTRNHGGKDHASSRYIYTKLS
         RSIPSMVDGLKPGQRKILF +FK+   KE KV+Q  GYVS  SAYHHGEQSLA  IIGMAQD+VGSNN+NLLLPNGQFGTR  GGKD AS+RYI+TKLS
Subjt:  LRSIPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLAGTIIGMAQDFVGSNNLNLLLPNGQFGTRNHGGKDHASSRYIYTKLS

Query:  NVTRFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGGEGIGTGWSTNIPNYNPRDIIRNVRRMLNDETMLPMDPWYRGFSGIIEKTATKDGCSSY
         VTR LFPKDDD LL+YLNEDGQ IEPTWYMPIIPTVLVNG EGIGTGWST IPNYNPR+I+ NVRR+LN E+M+PMDPWYRGF G IEKTA+K+G  +Y
Subjt:  NVTRFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGGEGIGTGWSTNIPNYNPRDIIRNVRRMLNDETMLPMDPWYRGFSGIIEKTATKDGCSSY

Query:  TVSGIVEEVSDTTLRITELPVRKWTNDYKEFLDSVTRTSKNDKDKEKAKDPFIEQADHHSDDKSVSIDVHLTDENMILAMQEGLKKKLKLTTTINTSNMH
        T++G+ EEV +TT+RITELP+R+W +DYK FL S+    K D        PF +    ++D+KSV  D+ L++ENM+ A QEG  KK KLTTTI TSNMH
Subjt:  TVSGIVEEVSDTTLRITELPVRKWTNDYKEFLDSVTRTSKNDKDKEKAKDPFIEQADHHSDDKSVSIDVHLTDENMILAMQEGLKKKLKLTTTINTSNMH

Query:  LFDANGMIKKYDTPEQILEEFFPLRLEYYEKRKRVLLENLEMELLKLENKARFILAVVNGEIIVSNRRRVDLVHELQAKGFTPFPKKTKSAEPEIAGASD
        LFD  G+IKKY TPEQILEEFF LR EYYEKRK  +++N+E+ELLKLENKARFILAV++GEIIV+ R++ D+V +L+ KGFTPFP+K +S E  IAGA D
Subjt:  LFDANGMIKKYDTPEQILEEFFPLRLEYYEKRKRVLLENLEMELLKLENKARFILAVVNGEIIVSNRRRVDLVHELQAKGFTPFPKKTKSAEPEIAGASD

Query:  ETDQTEESPEVKGDRV--------SDYEYLLALAIGTLTIEKVQELCNDRDKLKGEVEDLRKATPKSLWLNDLDSLEKELDEMDRNDAHVD---EVRKQQ
        + D  EE  E+  D          S+Y+YLLA+AI +LTIEKV+EL  DRDK+   V D++K TPKSLWL+DL+SL+KEL+++D  DA V    E  +++
Subjt:  ETDQTEESPEVKGDRV--------SDYEYLLALAIGTLTIEKVQELCNDRDKLKGEVEDLRKATPKSLWLNDLDSLEKELDEMDRNDAHVD---EVRKQQ

Query:  RIANNDVKPKITRNAPKAP---RNSKKTSHSETAVESSMDTTSSSTTMEVESNA--VVKPKGKAAAPRKAPAKKGKSAVVKDDAEDDDDEMLELKDRFAA
          A +    K+ R APK P   + +KK S SET       T +S + M+ ++N   VVKPK +  A +K  A + ++      A D D+ + E+      
Subjt:  RIANNDVKPKITRNAPKAP---RNSKKTSHSETAVESSMDTTSSSTTMEVESNA--VVKPKGKAAAPRKAPAKKGKSAVVKDDAEDDDDEMLELKDRFAA

Query:  YRIDSSPDRSEVSAMETEAPQVQAGKKKEPTKRAPAKKKTTAKSAQISDTDDEEFELKETGPPAGKKGGGGRKAAANAKTTKPPAPTKKREPAAKVGQKL
                 +     E E   +     +     APA    TA++++    DD++ ++     P  K   GGRK AA  K  KPPA  +KR      G++ 
Subjt:  YRIDSSPDRSEVSAMETEAPQVQAGKKKEPTKRAPAKKKTTAKSAQISDTDDEEFELKETGPPAGKKGGGGRKAAANAKTTKPPAPTKKREPAAKVGQKL

Query:  ITKMLVPAENSGISPEKKVRKIRASPSNKKSASILGMAGIEEEEEEDDDNNSDEEGKIMGGGGSASSDTTEESAGFVPARGRSQRTNRTQVKYVHSDSDS
        +    V A   G+SPEKKVRK+R+SP NKKS+S++      +EEE  ++               A + ++E+S G V A  R QR NR ++ YV SDS+S
Subjt:  ITKMLVPAENSGISPEKKVRKIRASPSNKKSASILGMAGIEEEEEEDDDNNSDEEGKIMGGGGSASSDTTEESAGFVPARGRSQRTNRTQVKYVHSDSDS

Query:  EPVAEDSDFDDKDDDFDED
        E  A DS+FDD +DD D++
Subjt:  EPVAEDSDFDDKDDDFDED

AT3G23890.2 topoisomerase II

0.0e+00

63.59

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Query:  KRPLQNSTAANVDQIPAGPK-----KTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYETDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMD
        K PLQNS AANV + PA  +     KTIEEMYQKK+QLEHILLRPDTY+GSIEKHTQ LWVYE D+MV R VTYVPGLYKIFDEILVNAADNKQRD  MD
Subjt:  KRPLQNSTAANVDQIPAGPK-----KTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYETDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMD

Query:  SLKVVIDAEQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDDEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRQKKYKQVFSDNMGKKGE
        S++VVID EQN ISV N+G GVPVEIHQEE +YVPE+IFGHLLTSSNYDD+ KKTTGGRNGYGAKLTNIFSTEF+IETADGKR KKYKQVF +NMGKK E
Subjt:  SLKVVIDAEQNCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDDEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRQKKYKQVFSDNMGKKGE

Query:  PIITKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASPS-TTDPPKRYHVKPNERWEIM
        P+ITKC + +NWTKVTFKPDL KFNMT LEDDVVALM KRV D+AGCLGK+VKVELNG+++PVKSF DYVDLYL +A+ S T DP  R   K N+RWE+ 
Subjt:  PIITKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASPS-TTDPPKRYHVKPNERWEIM

Query:  VTLSEGQFQQVSFVNGIATIKGGTHVDYITNQIANYVMNVVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSSFGSACELTPDFLKN
        V+LSEGQFQQVSFVN IATIKGGTHVDY+T+QI N+++  VNKKNKNANVKAHNVK++LWVF+NALIDNPAFDSQTKETLT+RQSSFGS CEL+ DFLK 
Subjt:  VTLSEGQFQQVSFVNGIATIKGGTHVDYITNQIANYVMNVVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSSFGSACELTPDFLKN

Query:  VAAKSGIMDSVLSWVNFKQSKDMKKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQI
        V  KSG+++++LSW +FKQ+KD+KK+DGAKT ++  +EKL+DA  AGGKNS  CTLILTEGDSAK+LA+AG  V+G ++ GVFPLRGKLLNVREAS+ QI
Subjt:  VAAKSGIMDSVLSWVNFKQSKDMKKTDGAKTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQI

Query:  TENKEIQYIKQILGLQQGKEYSNSKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKVPSFLVEFITPIVKATHRNGT--VLSFYTMPEYESWKE
        T NKEI+ +K+ILGL+Q  +Y N  +LRYG +MIMTDQDHDGSHIKGLLINFIHSFWPSLL+VPSFLVEFITPIVKAT R GT  VLSFY+MPEYE WKE
Subjt:  TENKEIQYIKQILGLQQGKEYSNSKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKVPSFLVEFITPIVKATHRNGT--VLSFYTMPEYESWKE

Query:  SLRGNANGWSIKYYKGLGTSTSKEGREYFEQLTRHKKDFIWQDDHDGEAIELAFSKKKIEERKNWLRHFEPGTHLDQTGKLIKYSDFVNKELILFSMADN
        SL+GNA GW IKYYKGLGTST++EG+EYF  L  HKKDF+W+D+ DGEAIELAFSKKKIE RKNWL  + PG HLDQ    + YSDFVNKELILFSMAD 
Subjt:  SLRGNANGWSIKYYKGLGTSTSKEGREYFEQLTRHKKDFIWQDDHDGEAIELAFSKKKIEERKNWLRHFEPGTHLDQTGKLIKYSDFVNKELILFSMADN

Query:  LRSIPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLAGTIIGMAQDFVGSNNLNLLLPNGQFGTRNHGGKDHASSRYIYTKLS
         RSIPSMVDGLKPGQRKILF +FK+   KE KV+Q  GYVS  SAYHHGEQSLA  IIGMAQD+VGSNN+NLLLPNGQFGTR  GGKD AS+RYI+TKLS
Subjt:  LRSIPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLAGTIIGMAQDFVGSNNLNLLLPNGQFGTRNHGGKDHASSRYIYTKLS

Query:  NVTRFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGGEGIGTGWSTNIPNYNPRDIIRNVRRMLNDETMLPMDPWYRGFSGIIEKTATKDGCSSY
         VTR LFPKDDD LL+YLNEDGQ IEPTWYMPIIPTVLVNG EGIGTGWST IPNYNPR+I+ NVRR+LN E+M+PMDPWYRGF G IEKTA+K+G  +Y
Subjt:  NVTRFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGGEGIGTGWSTNIPNYNPRDIIRNVRRMLNDETMLPMDPWYRGFSGIIEKTATKDGCSSY

Query:  TVSGIVEEVSDTTLRITELPVRKWTNDYKEFLDSVTRTSKNDKDKEKAKDPFIEQADHHSDDKSVSIDVHLTDENMILAMQEGLKKKLKLTTTINTSNMH
        T++G+ EEV +TT+RITELP+R+W +DYK FL S+    K D        PF +    ++D+KSV  D+ L++ENM+ A QEG  KK KLTTTI TSNMH
Subjt:  TVSGIVEEVSDTTLRITELPVRKWTNDYKEFLDSVTRTSKNDKDKEKAKDPFIEQADHHSDDKSVSIDVHLTDENMILAMQEGLKKKLKLTTTINTSNMH

Query:  LFDANGMIKKYDTPEQILEEFFPLRLEYYEKRKRVLLENLEMELLKLENKARFILAVVNGEIIVSNRRRVDLVHELQAKGFTPFPKKTKSAEPEIAGASD
        LFD  G+IKKY TPEQILEEFF LR EYYEKRK  +++N+E+ELLKLENKARFILAV++GEIIV+ R++ D+V +L+ KGFTPFP+K +S E  IAGA D
Subjt:  LFDANGMIKKYDTPEQILEEFFPLRLEYYEKRKRVLLENLEMELLKLENKARFILAVVNGEIIVSNRRRVDLVHELQAKGFTPFPKKTKSAEPEIAGASD

Query:  ETDQTEESPEVKGDRV--------SDYEYLLALAIGTLTIEKVQELCNDRDKLKGEVEDLRKATPKSLWLNDLDSLEKELDEMDRNDAHVD---EVRKQQ
        + D  EE  E+  D          S+Y+YLLA+AI +LTIEKV+EL  DRDK+   V D++K TPKSLWL+DL+SL+KEL+++D  DA V    E  +++
Subjt:  ETDQTEESPEVKGDRV--------SDYEYLLALAIGTLTIEKVQELCNDRDKLKGEVEDLRKATPKSLWLNDLDSLEKELDEMDRNDAHVD---EVRKQQ

Query:  RIANNDVKPKITRNAPKAP---RNSKKTSHSETAVESSMDTTSSSTTMEVESNA--VVKPKGKAAAPRKAPAKKGKSAVVKDDAEDDDDEMLELKDRFAA
          A +    K+ R APK P   + +KK S SET       T +S + M+ ++N   VVKPKG+  A +KAPA            E ++DEML+L  R A 
Subjt:  RIANNDVKPKITRNAPKAP---RNSKKTSHSETAVESSMDTTSSSTTMEVESNA--VVKPKGKAAAPRKAPAKKGKSAVVKDDAEDDDDEMLELKDRFAA

Query:  YRIDSSPDRSEVSAMETEAPQVQAGKKKEPTKRAPAKKKTTAKSAQISDTDDEEFELKETGPPAGKKGGGGRKAAANAKTTKPPAPTKKREPAAKVGQKL
        Y   S+P  S                            KT   S  I+  DD++  + E  P   KK  GGRK AA  K  KPPA  +KR      G++ 
Subjt:  YRIDSSPDRSEVSAMETEAPQVQAGKKKEPTKRAPAKKKTTAKSAQISDTDDEEFELKETGPPAGKKGGGGRKAAANAKTTKPPAPTKKREPAAKVGQKL

Query:  ITKMLVPAENSGISPEKKVRKIRASPSNKKSASILGMAGIEEEEEEDDDNNSDEEGKIMGGGGSASSDTTEESAGFVPARGRSQRTNRTQVKYVHSDSDS
        +    V A   G+SPEKKVRK+R+SP NKKS+S++      +EEE  ++               A + ++E+S G V A  R QR NR ++ YV SDS+S
Subjt:  ITKMLVPAENSGISPEKKVRKIRASPSNKKSASILGMAGIEEEEEEDDDNNSDEEGKIMGGGGSASSDTTEESAGFVPARGRSQRTNRTQVKYVHSDSDS

Query:  EPVAEDSDFDDKDDDFDED
        E  A DS+FDD +DD D++
Subjt:  EPVAEDSDFDDKDDDFDED

AT5G04130.1 DNA GYRASE B2

1.1e-29

24.68

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Query:  EMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYETDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMDSLKVVIDAEQNCISVFNNGDGVPVEIHQE
        E  Q    L+ +  RP  Y+GS                     T   GL+ +  EIL NA D  Q   +   + VV+ A+   +SV +NG G+P ++H  
Subjt:  EMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYETDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMDSLKVVIDAEQNCISVFNNGDGVPVEIHQE

Query:  EKVYVPELIFGHLLTSSNYDDDEK--KTTGGRNGYGAKLTNIFSTEFVIETADGKRQKKYKQVFSDNMGKKGEPIIT-KCK------EGDNWTKVTFKPD
         K    E +   L     +         +GG +G G  + N  S    +E +  +   ++KQ +S     +G+PI T  C+      +G   T + F PD
Subjt:  EKVYVPELIFGHLLTSSNYDDDEK--KTTGGRNGYGAKLTNIFSTEFVIETADGKRQKKYKQVFSDNMGKKGEPIIT-KCK------EGDNWTKVTFKPD

Query:  LAKFNMT-HLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASPSTTDPPKRYHVKPNERWEIMVTLSEGQFQ---------QV
           F      + + +A   + +  L   +  ++K E +       S   +     +  S   TD    + V    R EI     +   Q          +
Subjt:  LAKFNMT-HLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASPSTTDPPKRYHVKPNERWEIMVTLSEGQFQ---------QV

Query:  SFVNGIATIKGGTHVDYITNQIANYVMNVVNK----KNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETL---TIR-------QSSFGSACELTPDF
         + N I TI GGTH++ +   +   +  +  K    K K+ ++   +V+  L   ++  + NP F+ QTK  L    +R       Q       EL PD 
Subjt:  SFVNGIATIKGGTHVDYITNQIANYVMNVVNK----KNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETL---TIR-------QSSFGSACELTPDF

Query:  LKNVAAKSGIMDSVLSWVNFKQSKDMKKTDGA-KTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREAS
        L+++ +KS  +++  + +  K+++++ ++    K+  + G  KL D +    + SE   + + EGDSA   A  G     R F  + PLRGK+LN+    
Subjt:  LKNVAAKSGIMDSVLSWVNFKQSKDMKKTDGA-KTEKISGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREAS

Query:  SKQITENKEIQYIKQILGLQQGKEYSNSKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESW
           + +N+EIQ +   LGL    E    + LRY  ++I+TD D DG+HI+ LL+ F   +  +L       V  + P+ K   R       Y   + +  
Subjt:  SKQITENKEIQYIKQILGLQQGKEYSNSKALRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESW

Query:  KESLRGNANGWSIKYYKGLG
          +   NA+ ++I+ +KGLG
Subjt:  KESLRGNANGWSIKYYKGLG

AT5G53960.1 ATP binding;DNA binding;DNA topoisomerase (ATP-hydrolyzing)s

2.7e-04

26.92

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Query:  DENMILAMQEGLKKKLKLTTTINTSNMHLFDANGMIKKYDTPEQILEEFFPLRLEYYEKRKRVLLENLEMELLKLENKARFILAVVNGEIIVSNRRRVDL
        D+ M   +++ ++K  K+  ++   N +   A+   K Y     ILE+      E   +   V  +++E +L+KLENK R+I  V +  I + +  R  L
Subjt:  DENMILAMQEGLKKKLKLTTTINTSNMHLFDANGMIKKYDTPEQILEEFFPLRLEYYEKRKRVLLENLEMELLKLENKARFILAVVNGEIIVSNRRRVDL

Query:  VHELQAKGFTPFPKKTKSAEPEIAGASDETDQTEESPEVKGDRVSDYEYLLALAIGTLTIEKVQELCNDRDKLKGEVEDLRK
        V  L+ +GFTPFP                   +E+ P       S Y+YL       L I+K +ELC+ ++ L+  V  L++
Subjt:  VHELQAKGFTPFPKKTKSAEPEIAGASDETDQTEESPEVKGDRVSDYEYLLALAIGTLTIEKVQELCNDRDKLKGEVEDLRK

Sequences

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CDS sequence

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ATGGTTGTCGAGAAGAAGCGCCCACTGCAGAACAGCACCGCCGCCAATGTCGACCAGATTCCGGCAGGGCCGAAGAAAACAATCGAAGAAATGTACCAGAAGAAGACTCA
GCTCGAGCACATCCTCCTCCGGCCCGATACCTATGTCGGATCGATCGAAAAGCACACCCAAAACCTCTGGGTTTACGAGACCGACAAGATGGTCCACCGATCCGTCACCT
ATGTGCCTGGTCTCTACAAGATCTTTGATGAAATTTTGGTCAATGCGGCAGATAACAAGCAGAGAGACCCTTCGATGGACTCGCTCAAGGTTGTGATTGATGCGGAACAG
AACTGTATCAGTGTGTTCAACAATGGAGATGGAGTTCCTGTGGAGATTCATCAGGAAGAGAAGGTTTATGTTCCGGAGTTGATCTTTGGTCATCTGTTGACTAGTAGTAA
TTATGATGATGATGAGAAGAAAACCACTGGTGGAAGAAATGGCTACGGTGCGAAACTTACGAATATTTTTTCGACTGAATTTGTGATCGAGACGGCTGATGGAAAACGCC
AGAAGAAGTATAAGCAGGTATTCTCTGATAACATGGGAAAAAAAGGTGAGCCGATCATAACAAAGTGCAAGGAGGGTGATAATTGGACTAAAGTGACGTTTAAGCCAGAC
TTGGCGAAGTTTAACATGACCCATCTTGAAGATGATGTTGTTGCACTAATGAAGAAGAGAGTGTTGGATTTGGCTGGATGCCTTGGAAAAACCGTGAAGGTTGAGCTAAA
TGGACAAAGGGTCCCTGTCAAATCATTTCAAGATTATGTTGATCTCTACCTTAAATCAGCATCCCCTTCCACGACTGACCCTCCTAAAAGGTATCACGTTAAGCCTAATG
AGAGATGGGAAATCATGGTGACCTTAAGTGAGGGGCAGTTCCAACAGGTCAGCTTTGTGAATGGAATTGCCACTATAAAGGGTGGGACTCATGTTGATTACATCACTAAT
CAAATTGCTAATTATGTGATGAATGTTGTAAATAAGAAGAACAAAAATGCTAATGTGAAAGCACACAATGTGAAGAGTTATTTGTGGGTTTTTATCAATGCCCTCATTGA
TAATCCGGCCTTTGACTCTCAAACCAAAGAAACTTTGACCATTCGTCAAAGCAGTTTCGGCTCTGCATGTGAACTTACACCAGATTTTTTGAAAAATGTGGCTGCAAAAT
CTGGAATCATGGACAGCGTTCTTTCGTGGGTTAACTTCAAGCAAAGCAAAGATATGAAGAAAACCGATGGAGCAAAAACAGAAAAGATTAGTGGGATTGAAAAACTTGAG
GATGCCAATTGTGCTGGAGGGAAAAACTCAGAAAAATGTACCTTGATTTTGACAGAAGGAGATTCAGCCAAGGCCCTTGCAATGGCTGGACTCGGTGTAGTAGGGCGAGA
TTTCTATGGCGTATTCCCACTCAGAGGTAAACTGCTCAATGTGAGGGAAGCAAGTAGCAAACAGATCACAGAGAATAAAGAAATTCAGTACATCAAACAAATTCTTGGAC
TTCAGCAAGGGAAAGAATACTCCAATTCTAAGGCTTTGAGATACGGTCATTTGATGATTATGACTGATCAGGATCATGATGGTTCACACATTAAAGGACTCTTGATCAAC
TTTATACATTCCTTCTGGCCTTCTCTCCTAAAAGTGCCATCTTTTTTGGTTGAGTTCATTACGCCTATTGTCAAGGCTACTCACAGAAATGGAACTGTTTTGTCATTCTA
TACCATGCCCGAGTACGAATCTTGGAAAGAGAGCTTGAGGGGCAATGCAAATGGTTGGTCTATCAAGTACTATAAGGGGTTGGGAACAAGCACATCCAAAGAAGGAAGAG
AGTATTTTGAACAACTAACAAGGCACAAGAAAGATTTTATTTGGCAAGATGACCATGATGGAGAGGCTATTGAACTTGCTTTCAGTAAGAAGAAGATTGAAGAGAGGAAG
AATTGGCTCCGTCATTTTGAGCCCGGTACCCATCTAGATCAAACAGGGAAACTGATAAAATACAGCGACTTTGTCAACAAGGAACTTATATTATTTTCGATGGCTGATAA
TCTAAGGTCTATTCCCTCAATGGTTGATGGCCTCAAGCCTGGTCAGAGGAAGATCCTTTTCTGTTCTTTCAAGAGGAACTTCATCAAAGAAGCCAAAGTTTCTCAATTTT
CTGGTTATGTATCTGAGCATTCTGCCTATCATCATGGTGAGCAGAGTCTTGCTGGAACCATCATTGGAATGGCACAGGACTTCGTAGGCAGTAACAACTTGAATCTTCTT
TTGCCGAATGGACAGTTTGGCACCCGAAACCATGGAGGCAAAGATCATGCAAGTTCTAGGTACATTTACACCAAGCTTTCAAATGTTACACGGTTTCTTTTCCCGAAAGA
TGACGACAAGCTTCTTAACTACTTAAATGAAGATGGCCAGTCAATTGAACCAACTTGGTATATGCCTATCATACCAACGGTTCTTGTCAACGGAGGTGAAGGAATTGGAA
CTGGGTGGAGTACTAACATTCCAAATTATAATCCTAGAGATATCATCAGAAATGTTAGACGCATGTTGAATGACGAAACAATGTTGCCAATGGATCCTTGGTATAGAGGC
TTTTCAGGAATTATTGAGAAAACTGCCACTAAAGATGGATGTAGTAGTTACACTGTTAGTGGAATTGTAGAGGAAGTAAGTGACACGACATTGAGAATAACCGAACTACC
AGTTCGCAAATGGACTAATGATTATAAGGAATTCCTTGATTCTGTCACGAGGACATCCAAGAATGATAAAGACAAAGAAAAAGCAAAGGATCCTTTTATTGAGCAAGCTG
ATCACCACAGTGATGACAAAAGTGTTTCCATTGATGTTCACTTGACAGACGAAAACATGATATTGGCCATGCAGGAGGGTTTGAAAAAGAAACTCAAATTGACTACGACT
ATCAACACCAGCAACATGCATTTGTTTGATGCAAATGGCATGATAAAGAAATATGACACCCCAGAACAAATTCTTGAAGAATTTTTCCCCCTTAGACTTGAATACTATGA
GAAGAGAAAGAGAGTTCTTTTGGAGAACCTTGAAATGGAGTTGCTTAAACTGGAGAACAAGGCGAGGTTTATCCTTGCTGTTGTGAATGGAGAGATAATAGTAAGCAATA
GAAGGAGAGTTGATTTGGTCCATGAGCTTCAAGCGAAAGGCTTTACACCCTTTCCAAAGAAAACTAAGTCTGCTGAGCCAGAGATTGCTGGGGCATCTGATGAAACAGAT
CAAACAGAGGAGAGTCCGGAAGTAAAAGGGGATCGGGTTAGTGACTACGAGTATCTATTGGCTTTGGCAATTGGAACCTTGACCATTGAAAAGGTTCAGGAGCTATGTAA
TGATAGAGACAAGCTCAAAGGGGAAGTAGAAGATCTGAGGAAGGCAACCCCCAAGTCTTTGTGGCTGAATGATCTTGATTCTCTTGAGAAAGAACTTGATGAGATGGATA
GAAATGATGCTCATGTAGATGAGGTAAGAAAACAGCAAAGAATAGCAAATAATGATGTCAAGCCAAAGATCACTAGAAATGCACCAAAAGCTCCACGTAACAGCAAGAAA
ACCAGCCATTCAGAAACCGCCGTGGAAAGTAGTATGGACACAACATCTAGTTCTACAACAATGGAAGTTGAAAGCAACGCAGTGGTGAAGCCCAAAGGCAAAGCAGCAGC
TCCCAGAAAAGCTCCCGCTAAAAAGGGTAAATCTGCAGTTGTCAAGGATGATGCTGAAGATGACGACGACGAAATGCTCGAACTTAAAGATCGTTTTGCTGCCTACAGAA
TTGATTCATCTCCTGATCGTTCGGAAGTTTCAGCCATGGAAACTGAAGCGCCACAAGTCCAAGCAGGCAAGAAGAAAGAACCCACCAAGAGGGCACCTGCCAAGAAGAAA
ACCACTGCAAAGTCGGCCCAGATTTCCGACACCGACGACGAGGAGTTCGAACTAAAGGAGACCGGTCCTCCGGCCGGCAAGAAGGGAGGAGGAGGAAGAAAGGCAGCTGC
AAATGCTAAAACAACCAAACCCCCTGCACCAACCAAGAAGCGAGAACCGGCAGCCAAGGTGGGGCAGAAGCTAATAACTAAAATGCTGGTTCCGGCGGAGAACTCCGGCA
TCTCGCCGGAGAAGAAGGTGAGAAAGATCAGAGCATCGCCTTCCAACAAGAAAAGTGCCTCTATTTTGGGAATGGCTGGGATAGAAGAAGAAGAAGAAGAAGATGATGAT
AATAATAGTGATGAAGAAGGGAAGATAATGGGTGGTGGTGGTTCTGCTTCTTCTGATACGACGGAGGAATCCGCCGGATTTGTGCCGGCGAGAGGAAGATCACAAAGGAC
CAACAGAACTCAGGTGAAATATGTTCATAGTGATTCAGACAGTGAACCAGTTGCCGAGGATTCTGACTTTGATGATAAAGATGATGATTTTGATGAAGATTGA

mRNA sequence

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Protein sequence

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MVVEKKRPLQNSTAANVDQIPAGPKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYETDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMDSLKVVIDAEQ
NCISVFNNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDDEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRQKKYKQVFSDNMGKKGEPIITKCKEGDNWTKVTFKPD
LAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASPSTTDPPKRYHVKPNERWEIMVTLSEGQFQQVSFVNGIATIKGGTHVDYITN
QIANYVMNVVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSSFGSACELTPDFLKNVAAKSGIMDSVLSWVNFKQSKDMKKTDGAKTEKISGIEKLE
DANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASSKQITENKEIQYIKQILGLQQGKEYSNSKALRYGHLMIMTDQDHDGSHIKGLLIN
FIHSFWPSLLKVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWKESLRGNANGWSIKYYKGLGTSTSKEGREYFEQLTRHKKDFIWQDDHDGEAIELAFSKKKIEERK
NWLRHFEPGTHLDQTGKLIKYSDFVNKELILFSMADNLRSIPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFSGYVSEHSAYHHGEQSLAGTIIGMAQDFVGSNNLNLL
LPNGQFGTRNHGGKDHASSRYIYTKLSNVTRFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGGEGIGTGWSTNIPNYNPRDIIRNVRRMLNDETMLPMDPWYRG
FSGIIEKTATKDGCSSYTVSGIVEEVSDTTLRITELPVRKWTNDYKEFLDSVTRTSKNDKDKEKAKDPFIEQADHHSDDKSVSIDVHLTDENMILAMQEGLKKKLKLTTT
INTSNMHLFDANGMIKKYDTPEQILEEFFPLRLEYYEKRKRVLLENLEMELLKLENKARFILAVVNGEIIVSNRRRVDLVHELQAKGFTPFPKKTKSAEPEIAGASDETD
QTEESPEVKGDRVSDYEYLLALAIGTLTIEKVQELCNDRDKLKGEVEDLRKATPKSLWLNDLDSLEKELDEMDRNDAHVDEVRKQQRIANNDVKPKITRNAPKAPRNSKK
TSHSETAVESSMDTTSSSTTMEVESNAVVKPKGKAAAPRKAPAKKGKSAVVKDDAEDDDDEMLELKDRFAAYRIDSSPDRSEVSAMETEAPQVQAGKKKEPTKRAPAKKK
TTAKSAQISDTDDEEFELKETGPPAGKKGGGGRKAAANAKTTKPPAPTKKREPAAKVGQKLITKMLVPAENSGISPEKKVRKIRASPSNKKSASILGMAGIEEEEEEDDD
NNSDEEGKIMGGGGSASSDTTEESAGFVPARGRSQRTNRTQVKYVHSDSDSEPVAEDSDFDDKDDDFDED

Sed0008745 (gene) of Chayote v1 genome