CuGenDBv2

Gene ID	Sed0010073
Organism	Sechium edule (Chayote v1)
Description	DNA oxidative demethylase ALKBH2
Genome location	LG14:21765253..21766561
RNA-Seq Expression	Sed0010073
Synteny	Sed0010073
Gene Ontology terms	GO:0006281 - DNA repair (biological process) GO:0003824 - catalytic activity (molecular function)
InterPro domains	IPR032852 - DNA oxidative demethylase ALKBH2 IPR037151 - Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily

Homology

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GenBank top hits

e value

%identity

Alignment

KAG6603836.1 DNA oxidative demethylase ALKBH2, partial [Cucurbita argyrosperma subsp. sororia]

8.5e-43

52.94

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Query:  MVYTSNFMVSDRAWTRFDFRNQRIPWTRPTVRVVGRSVVQPRDTCYVASPGLTTLAYSGCKPLAYTWDDFPPRKDILNAP---------SYVLLDVVSG-
        +VY S F+ SD+AWT FDF NQ IPWTRPT+RV GRSVVQPRDTCYV +PGLTT +YSG KP AYTWDDFPP KDILNA          + +LL+   G 
Subjt:  MVYTSNFMVSDRAWTRFDFRNQRIPWTRPTVRVVGRSVVQPRDTCYVASPGLTTLAYSGCKPLAYTWDDFPPRKDILNAP---------SYVLLDVVSG-

Query:  -------------------------------------------RYDVEPPRKKSKKSSEADTHSFVLKHGSLLVMKGYTQRGWVNNL
                                                   R D EPP KKSKKSS ADTHSFVLKHGSLLVMKGYTQR W++++
Subjt:  -------------------------------------------RYDVEPPRKKSKKSSEADTHSFVLKHGSLLVMKGYTQRGWVNNL

XP_022950476.1 DNA oxidative demethylase ALKBH2 isoform X1 [Cucurbita moschata]

8.5e-43

52.94

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Query:  MVYTSNFMVSDRAWTRFDFRNQRIPWTRPTVRVVGRSVVQPRDTCYVASPGLTTLAYSGCKPLAYTWDDFPPRKDILNAP---------SYVLLDVVSG-
        +VY S F+ SD+AWT FDF NQ IPWTRPT+RV GRSVVQPRDTCYV +PGLTT +YSG KP AYTWDDFPP KDILNA          + +LL+   G 
Subjt:  MVYTSNFMVSDRAWTRFDFRNQRIPWTRPTVRVVGRSVVQPRDTCYVASPGLTTLAYSGCKPLAYTWDDFPPRKDILNAP---------SYVLLDVVSG-

Query:  -------------------------------------------RYDVEPPRKKSKKSSEADTHSFVLKHGSLLVMKGYTQRGWVNNL
                                                   R D EPP KKSKKSS ADTHSFVLKHGSLLVMKGYTQR W++++
Subjt:  -------------------------------------------RYDVEPPRKKSKKSSEADTHSFVLKHGSLLVMKGYTQRGWVNNL

XP_022950477.1 DNA oxidative demethylase ALKBH2 isoform X2 [Cucurbita moschata]

8.5e-43

52.94

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Query:  MVYTSNFMVSDRAWTRFDFRNQRIPWTRPTVRVVGRSVVQPRDTCYVASPGLTTLAYSGCKPLAYTWDDFPPRKDILNAP---------SYVLLDVVSG-
        +VY S F+ SD+AWT FDF NQ IPWTRPT+RV GRSVVQPRDTCYV +PGLTT +YSG KP AYTWDDFPP KDILNA          + +LL+   G 
Subjt:  MVYTSNFMVSDRAWTRFDFRNQRIPWTRPTVRVVGRSVVQPRDTCYVASPGLTTLAYSGCKPLAYTWDDFPPRKDILNAP---------SYVLLDVVSG-

Query:  -------------------------------------------RYDVEPPRKKSKKSSEADTHSFVLKHGSLLVMKGYTQRGWVNNL
                                                   R D EPP KKSKKSS ADTHSFVLKHGSLLVMKGYTQR W++++
Subjt:  -------------------------------------------RYDVEPPRKKSKKSSEADTHSFVLKHGSLLVMKGYTQRGWVNNL

XP_022977708.1 DNA oxidative demethylase ALKBH2 [Cucurbita maxima]

4.2e-42

52.41

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Query:  MVYTSNFMVSDRAWTRFDFRNQRIPWTRPTVRVVGRSVVQPRDTCYVASPGLTTLAYSGCKPLAYTWDDFPPRKDILNAP---------SYVLLDVVSG-
        +VY S F+ SD+AWT FDF NQ IPWTRPT+RV GRSVVQPRDTCYV +PGLT  +YSG KP AYTWDDFPP KDILNA          + +LL+   G 
Subjt:  MVYTSNFMVSDRAWTRFDFRNQRIPWTRPTVRVVGRSVVQPRDTCYVASPGLTTLAYSGCKPLAYTWDDFPPRKDILNAP---------SYVLLDVVSG-

Query:  -------------------------------------------RYDVEPPRKKSKKSSEADTHSFVLKHGSLLVMKGYTQRGWVNNL
                                                   R D EPP KKSKKSS ADTHSFVLKHGSLLVMKGYTQR W++++
Subjt:  -------------------------------------------RYDVEPPRKKSKKSSEADTHSFVLKHGSLLVMKGYTQRGWVNNL

XP_038882915.1 DNA oxidative demethylase ALKBH2 [Benincasa hispida]

4.2e-42

51.87

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Query:  MVYTSNFMVSDRAWTRFDFRNQRIPWTRPTVRVVGRSVVQPRDTCYVASPGLTTLAYSGCKPLAYTWDDFPPRKDILNAP---------SYVLLDVVSG-
        +VY   F+ SD+AWT FDF NQRIPWTRPT+RV GRSV+QPRDTCYVA+PGLTTL YSG KP AYTWDDFPP KDIL+A          + +LL+   G 
Subjt:  MVYTSNFMVSDRAWTRFDFRNQRIPWTRPTVRVVGRSVVQPRDTCYVASPGLTTLAYSGCKPLAYTWDDFPPRKDILNAP---------SYVLLDVVSG-

Query:  -------------------------------------------RYDVEPPRKKSKKSSEADTHSFVLKHGSLLVMKGYTQRGWVNNL
                                                   R D EPP KKSKKSS AD+HSFVLKHGSLLVM+GYTQR W++++
Subjt:  -------------------------------------------RYDVEPPRKKSKKSSEADTHSFVLKHGSLLVMKGYTQRGWVNNL

TrEMBL top hits

e value

%identity

Alignment

A0A0A0KL20 Fe2OG dioxygenase domain-containing protein

8.5e-41

51.34

Show/hide

Query:  MVYTSNFMVSDRAWTRFDFRNQRIPWTRPTVRVVGRSVVQPRDTCYVASPGLTTLAYSGCKPLAYTWDDFPPRKDILNAP---------SYVLLDVVSG-
        ++Y S F+ SD+AWT FDF NQRIPWTRPT+ V GRSV+QPRDTCYVA+PGLTTL YSG KP AYTWDDF P KDIL+A          + +LL+   G 
Subjt:  MVYTSNFMVSDRAWTRFDFRNQRIPWTRPTVRVVGRSVVQPRDTCYVASPGLTTLAYSGCKPLAYTWDDFPPRKDILNAP---------SYVLLDVVSG-

Query:  -------------------------------------------RYDVEPPRKKSKKSSEADTHSFVLKHGSLLVMKGYTQRGWVNNL
                                                   R D EPP KKSKKSS AD HSFVLKHGSLLVMKGYTQR W++++
Subjt:  -------------------------------------------RYDVEPPRKKSKKSSEADTHSFVLKHGSLLVMKGYTQRGWVNNL

A0A6J1BTV9 DNA oxidative demethylase ALKBH2

3.5e-42

51.34

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Query:  MVYTSNFMVSDRAWTRFDFRNQRIPWTRPTVRVVGRSVVQPRDTCYVASPGLTTLAYSGCKPLAYTWDDFPPRKDILNAP---------SYVLLDVVSG-
        +VY + F+ SD+AWT FDF NQRIPWTRPT+RV GRS++QPRDTCYVASPGLTTL YSG KP AYTWDDFPP K+IL+A          + +LL+   G 
Subjt:  MVYTSNFMVSDRAWTRFDFRNQRIPWTRPTVRVVGRSVVQPRDTCYVASPGLTTLAYSGCKPLAYTWDDFPPRKDILNAP---------SYVLLDVVSG-

Query:  -------------------------------------------RYDVEPPRKKSKKSSEADTHSFVLKHGSLLVMKGYTQRGWVNNL
                                                   R D EPP KKSKKS  ADTHSF LKHGSLLVMKGYTQR W++++
Subjt:  -------------------------------------------RYDVEPPRKKSKKSSEADTHSFVLKHGSLLVMKGYTQRGWVNNL

A0A6J1GEX8 DNA oxidative demethylase ALKBH2 isoform X1

4.1e-43

52.94

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Query:  MVYTSNFMVSDRAWTRFDFRNQRIPWTRPTVRVVGRSVVQPRDTCYVASPGLTTLAYSGCKPLAYTWDDFPPRKDILNAP---------SYVLLDVVSG-
        +VY S F+ SD+AWT FDF NQ IPWTRPT+RV GRSVVQPRDTCYV +PGLTT +YSG KP AYTWDDFPP KDILNA          + +LL+   G 
Subjt:  MVYTSNFMVSDRAWTRFDFRNQRIPWTRPTVRVVGRSVVQPRDTCYVASPGLTTLAYSGCKPLAYTWDDFPPRKDILNAP---------SYVLLDVVSG-

Query:  -------------------------------------------RYDVEPPRKKSKKSSEADTHSFVLKHGSLLVMKGYTQRGWVNNL
                                                   R D EPP KKSKKSS ADTHSFVLKHGSLLVMKGYTQR W++++
Subjt:  -------------------------------------------RYDVEPPRKKSKKSSEADTHSFVLKHGSLLVMKGYTQRGWVNNL

A0A6J1GEX9 DNA oxidative demethylase ALKBH2 isoform X2

4.1e-43

52.94

Show/hide

Query:  MVYTSNFMVSDRAWTRFDFRNQRIPWTRPTVRVVGRSVVQPRDTCYVASPGLTTLAYSGCKPLAYTWDDFPPRKDILNAP---------SYVLLDVVSG-
        +VY S F+ SD+AWT FDF NQ IPWTRPT+RV GRSVVQPRDTCYV +PGLTT +YSG KP AYTWDDFPP KDILNA          + +LL+   G 
Subjt:  MVYTSNFMVSDRAWTRFDFRNQRIPWTRPTVRVVGRSVVQPRDTCYVASPGLTTLAYSGCKPLAYTWDDFPPRKDILNAP---------SYVLLDVVSG-

Query:  -------------------------------------------RYDVEPPRKKSKKSSEADTHSFVLKHGSLLVMKGYTQRGWVNNL
                                                   R D EPP KKSKKSS ADTHSFVLKHGSLLVMKGYTQR W++++
Subjt:  -------------------------------------------RYDVEPPRKKSKKSSEADTHSFVLKHGSLLVMKGYTQRGWVNNL

A0A6J1IQU8 DNA oxidative demethylase ALKBH2

2.0e-42

52.41

Show/hide

Query:  MVYTSNFMVSDRAWTRFDFRNQRIPWTRPTVRVVGRSVVQPRDTCYVASPGLTTLAYSGCKPLAYTWDDFPPRKDILNAP---------SYVLLDVVSG-
        +VY S F+ SD+AWT FDF NQ IPWTRPT+RV GRSVVQPRDTCYV +PGLT  +YSG KP AYTWDDFPP KDILNA          + +LL+   G 
Subjt:  MVYTSNFMVSDRAWTRFDFRNQRIPWTRPTVRVVGRSVVQPRDTCYVASPGLTTLAYSGCKPLAYTWDDFPPRKDILNAP---------SYVLLDVVSG-

Query:  -------------------------------------------RYDVEPPRKKSKKSSEADTHSFVLKHGSLLVMKGYTQRGWVNNL
                                                   R D EPP KKSKKSS ADTHSFVLKHGSLLVMKGYTQR W++++
Subjt:  -------------------------------------------RYDVEPPRKKSKKSSEADTHSFVLKHGSLLVMKGYTQRGWVNNL

SwissProt top hits

e value

%identity

Alignment

Q9SIE0 DNA oxidative demethylase ALKBH2

1.1e-32

38.62

Show/hide

Query:  MVYTSNFMVSDRAWTRFDFRNQRIPWTRPTVRVVGRSVVQPRDTCYVASPGLTTLAYSGCKPLAYTWDDFPPRKDILNA-----PSYVLLDVVSGRY---
        ++Y   F+   ++WT FD+ ++ IPWTRPT+RV GRS +QPRDTCYVAS GLT L YSG +P +Y+WDDFPP K+IL+A     P      ++  RY   
Subjt:  MVYTSNFMVSDRAWTRFDFRNQRIPWTRPTVRVVGRSVVQPRDTCYVASPGLTTLAYSGCKPLAYTWDDFPPRKDILNA-----PSYVLLDVVSGRY---

Query:  -----------------------------------------------DVEPPRKKSKKSSEADTHSFVLKHGSLLVMKGYTQRGWVNNL
                                                       D  P +K+ K+SS  D  S  LKHGSLLVM+GYTQR W++++
Subjt:  -----------------------------------------------DVEPPRKKSKKSSEADTHSFVLKHGSLLVMKGYTQRGWVNNL

Arabidopsis top hits

e value

%identity

Alignment

AT2G22260.1 oxidoreductase, 2OG-Fe(II) oxygenase family protein

7.6e-34

38.62

Show/hide

Query:  MVYTSNFMVSDRAWTRFDFRNQRIPWTRPTVRVVGRSVVQPRDTCYVASPGLTTLAYSGCKPLAYTWDDFPPRKDILNA-----PSYVLLDVVSGRY---
        ++Y   F+   ++WT FD+ ++ IPWTRPT+RV GRS +QPRDTCYVAS GLT L YSG +P +Y+WDDFPP K+IL+A     P      ++  RY   
Subjt:  MVYTSNFMVSDRAWTRFDFRNQRIPWTRPTVRVVGRSVVQPRDTCYVASPGLTTLAYSGCKPLAYTWDDFPPRKDILNA-----PSYVLLDVVSGRY---

Query:  -----------------------------------------------DVEPPRKKSKKSSEADTHSFVLKHGSLLVMKGYTQRGWVNNL
                                                       D  P +K+ K+SS  D  S  LKHGSLLVM+GYTQR W++++
Subjt:  -----------------------------------------------DVEPPRKKSKKSSEADTHSFVLKHGSLLVMKGYTQRGWVNNL

Sequences

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CDS sequence

Show/hide CDS sequence

ATGGTGTACACTAGCAACTTCATGGTCTCCGATCGGGCTTGGACCCGGTTCGATTTTCGCAATCAACGCATTCCATGGACCAGGCCGACCGTTCGCGTCGTCGGTCGCTC
CGTCGTTCAGCCTAGAGATACTTGCTACGTTGCGAGTCCTGGATTGACGACGTTAGCTTATAGTGGGTGTAAACCTCTTGCCTATACTTGGGATGATTTTCCTCCTCGTA
AGGACATTTTGAATGCTCCATCTTATGTTTTACTTGATGTGGTTTCAGGCAGATATGATGTGGAGCCTCCAAGAAAGAAATCGAAGAAAAGCAGTGAGGCTGATACACAC
TCGTTTGTACTAAAGCATGGTTCACTTTTGGTTATGAAAGGGTACACTCAACGAGGTTGGGTGAACAACCTGCATCAACCTTACTTTCAGGCACGTTGTTGTTGA

mRNA sequence

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Protein sequence

Show/hide protein sequence

MVYTSNFMVSDRAWTRFDFRNQRIPWTRPTVRVVGRSVVQPRDTCYVASPGLTTLAYSGCKPLAYTWDDFPPRKDILNAPSYVLLDVVSGRYDVEPPRKKSKKSSEADTH
SFVLKHGSLLVMKGYTQRGWVNNLHQPYFQARCC

Sed0010073 (gene) of Chayote v1 genome