CuGenDBv2

Gene ID	Sed0015505
Organism	Sechium edule (Chayote v1)
Description	DNA topoisomerase 2
Genome location	LG04:34396343..34396863
RNA-Seq Expression	Sed0015505
Synteny	Sed0015505
Gene Ontology terms	GO:0009987 - cellular process (biological process) GO:0005488 - binding (molecular function)
InterPro domains	NA

Homology

Show/hide homology

GenBank top hits

e value

%identity

Alignment

XP_022152631.1 DNA topoisomerase 2 isoform X1 [Momordica charantia]

4.5e-29

50.98

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Query:  DVSAMETEGP-----AEKKEPSKRAAATKKTSVTSAQTS-------------------------QAAANGKTTKPPAAGK--------------------
        +VSAMETE P     A+KKEPSKRA A KKT+  SAQ S                         + AAN KTTKPPAA K                    
Subjt:  DVSAMETEGP-----AEKKEPSKRAAATKKTSVTSAQTS-------------------------QAAANGKTTKPPAAGK--------------------

Query:  --NLGIMPEKKVRKIRASPFNKKSGSILGTVSLEGD------GNEGKMMGSASSETTEETAGYPLERGRSQRSNRTQVRYVVSDSDSE---QPDAEDSDF
          N GI PEKKVRK+RASPFNKKSGSILG V  E +      GNEGK+MGSASSET EE+AG+   RGRSQR+NRTQV+YV+SDSDS+   + D +D DF
Subjt:  --NLGIMPEKKVRKIRASPFNKKSGSILGTVSLEGD------GNEGKMMGSASSETTEETAGYPLERGRSQRSNRTQVRYVVSDSDSE---QPDAEDSDF

Query:  EEED
        ++ED
Subjt:  EEED

XP_022152632.1 DNA topoisomerase 2 isoform X2 [Momordica charantia]

3.8e-28

50.24

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Query:  DDVSAMETEGP-----AEKKEPSKRAAATKKTSVTSAQTS-------------------------QAAANGKTTKPPAAGK-------------------
        D   AMETE P     A+KKEPSKRA A KKT+  SAQ S                         + AAN KTTKPPAA K                   
Subjt:  DDVSAMETEGP-----AEKKEPSKRAAATKKTSVTSAQTS-------------------------QAAANGKTTKPPAAGK-------------------

Query:  ---NLGIMPEKKVRKIRASPFNKKSGSILGTVSLEGD------GNEGKMMGSASSETTEETAGYPLERGRSQRSNRTQVRYVVSDSDSE---QPDAEDSD
           N GI PEKKVRK+RASPFNKKSGSILG V  E +      GNEGK+MGSASSET EE+AG+   RGRSQR+NRTQV+YV+SDSDS+   + D +D D
Subjt:  ---NLGIMPEKKVRKIRASPFNKKSGSILGTVSLEGD------GNEGKMMGSASSETTEETAGYPLERGRSQRSNRTQVRYVVSDSDSE---QPDAEDSD

Query:  FEEED
        F++ED
Subjt:  FEEED

XP_022982562.1 DNA topoisomerase 2 isoform X1 [Cucurbita maxima]

3.8e-28

55.67

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Query:  DVSAMETEGP-----AEKKEPSKRAAATKKTSVTSAQTS------------------------QAAANGKTTK-----PPAA-------------GKNLG
        +VSAMETE P     A+KKEPSKRAAA KKT+  SAQ S                        +AAAN KTTK      P A              +N G
Subjt:  DVSAMETEGP-----AEKKEPSKRAAATKKTSVTSAQTS------------------------QAAANGKTTK-----PPAA-------------GKNLG

Query:  IMPEKKVRKIRASPFNKKSGSILG------TVSLEGDGNEGKMMGSASSETT-EETAGYPLERGRSQRSNRTQVRYVVSDSDSEQPDAEDSDFEEEDGDF
        I PEKKVRKIR SPFNKKSGS+LG         +E  GNEGKMMGSASSETT EE A  PL RGRSQR+NRTQVRYVVSDSDSE P  EDSDF+EE  D 
Subjt:  IMPEKKVRKIRASPFNKKSGSILG------TVSLEGDGNEGKMMGSASSETT-EETAGYPLERGRSQRSNRTQVRYVVSDSDSEQPDAEDSDFEEEDGDF

Query:  DED
        DED
Subjt:  DED

XP_022982563.1 DNA topoisomerase 2 isoform X2 [Cucurbita maxima]

3.8e-28

55.67

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Query:  DVSAMETEGP-----AEKKEPSKRAAATKKTSVTSAQTS------------------------QAAANGKTTK-----PPAA-------------GKNLG
        +VSAMETE P     A+KKEPSKRAAA KKT+  SAQ S                        +AAAN KTTK      P A              +N G
Subjt:  DVSAMETEGP-----AEKKEPSKRAAATKKTSVTSAQTS------------------------QAAANGKTTK-----PPAA-------------GKNLG

Query:  IMPEKKVRKIRASPFNKKSGSILG------TVSLEGDGNEGKMMGSASSETT-EETAGYPLERGRSQRSNRTQVRYVVSDSDSEQPDAEDSDFEEEDGDF
        I PEKKVRKIR SPFNKKSGS+LG         +E  GNEGKMMGSASSETT EE A  PL RGRSQR+NRTQVRYVVSDSDSE P  EDSDF+EE  D 
Subjt:  IMPEKKVRKIRASPFNKKSGSILG------TVSLEGDGNEGKMMGSASSETT-EETAGYPLERGRSQRSNRTQVRYVVSDSDSEQPDAEDSDFEEEDGDF

Query:  DED
        DED
Subjt:  DED

XP_023527823.1 DNA topoisomerase 2 isoform X3 [Cucurbita pepo subsp. pepo]

1.1e-27

55.45

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Query:  DVSAMETEGP-----AEKKEPSKRAAATKKTSVTSAQTS------------------------QAAANGKTTK-----PPAA-------------GKNLG
        +VSAMETE P     A+KKEPSKRAAA KKT+  SAQ S                        +AAAN KTTK      P A              +N G
Subjt:  DVSAMETEGP-----AEKKEPSKRAAATKKTSVTSAQTS------------------------QAAANGKTTK-----PPAA-------------GKNLG

Query:  IMPEKKVRKIRASPFNKKSGSILGTVSLEGD-----GNEGKMMGSASSETTEETAG-YPLERGRSQRSNRTQVRYVVSDSDSEQPDAEDSDFEEEDGDFD
        I PEKKVRKIR SPFNKKSGS+LG    E +     GNEGKMMGSASSETT+E  G  PL RGRSQR+NRTQVRYVVSDSDSE P  EDSDF+EE  D D
Subjt:  IMPEKKVRKIRASPFNKKSGSILGTVSLEGD-----GNEGKMMGSASSETTEETAG-YPLERGRSQRSNRTQVRYVVSDSDSEQPDAEDSDFEEEDGDFD

Query:  ED
        ED
Subjt:  ED

TrEMBL top hits

e value

%identity

Alignment

A0A6J1DGT3 DNA topoisomerase 2

1.9e-28

50.24

Show/hide

Query:  DDVSAMETEGP-----AEKKEPSKRAAATKKTSVTSAQTS-------------------------QAAANGKTTKPPAAGK-------------------
        D   AMETE P     A+KKEPSKRA A KKT+  SAQ S                         + AAN KTTKPPAA K                   
Subjt:  DDVSAMETEGP-----AEKKEPSKRAAATKKTSVTSAQTS-------------------------QAAANGKTTKPPAAGK-------------------

Query:  ---NLGIMPEKKVRKIRASPFNKKSGSILGTVSLEGD------GNEGKMMGSASSETTEETAGYPLERGRSQRSNRTQVRYVVSDSDSE---QPDAEDSD
           N GI PEKKVRK+RASPFNKKSGSILG V  E +      GNEGK+MGSASSET EE+AG+   RGRSQR+NRTQV+YV+SDSDS+   + D +D D
Subjt:  ---NLGIMPEKKVRKIRASPFNKKSGSILGTVSLEGD------GNEGKMMGSASSETTEETAGYPLERGRSQRSNRTQVRYVVSDSDSE---QPDAEDSD

Query:  FEEED
        F++ED
Subjt:  FEEED

A0A6J1DIB5 DNA topoisomerase 2

2.2e-29

50.98

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Query:  DVSAMETEGP-----AEKKEPSKRAAATKKTSVTSAQTS-------------------------QAAANGKTTKPPAAGK--------------------
        +VSAMETE P     A+KKEPSKRA A KKT+  SAQ S                         + AAN KTTKPPAA K                    
Subjt:  DVSAMETEGP-----AEKKEPSKRAAATKKTSVTSAQTS-------------------------QAAANGKTTKPPAAGK--------------------

Query:  --NLGIMPEKKVRKIRASPFNKKSGSILGTVSLEGD------GNEGKMMGSASSETTEETAGYPLERGRSQRSNRTQVRYVVSDSDSE---QPDAEDSDF
          N GI PEKKVRK+RASPFNKKSGSILG V  E +      GNEGK+MGSASSET EE+AG+   RGRSQR+NRTQV+YV+SDSDS+   + D +D DF
Subjt:  --NLGIMPEKKVRKIRASPFNKKSGSILGTVSLEGD------GNEGKMMGSASSETTEETAGYPLERGRSQRSNRTQVRYVVSDSDSE---QPDAEDSDF

Query:  EEED
        ++ED
Subjt:  EEED

A0A6J1F9E0 DNA topoisomerase 2

1.2e-27

55.17

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Query:  DVSAMETEGP-----AEKKEPSKRAAATKKTSVTSAQTS------------------------QAAANGKTTK-----PPAA-------------GKNLG
        +VSAMETE P     A+KKEPSKRAAA KKT+  SAQ S                        +AAAN KTTK      P A              +N G
Subjt:  DVSAMETEGP-----AEKKEPSKRAAATKKTSVTSAQTS------------------------QAAANGKTTK-----PPAA-------------GKNLG

Query:  IMPEKKVRKIRASPFNKKSGSILG------TVSLEGDGNEGKMMGSASSETT-EETAGYPLERGRSQRSNRTQVRYVVSDSDSEQPDAEDSDFEEEDGDF
        I PEKKVRKIR SPFNKKSGS+LG         +E  GNEGKMMGSASSETT EE A  PL RGRSQR+NRTQVRYVVSDSDSE P  EDSDF+EE  + 
Subjt:  IMPEKKVRKIRASPFNKKSGSILG------TVSLEGDGNEGKMMGSASSETT-EETAGYPLERGRSQRSNRTQVRYVVSDSDSEQPDAEDSDFEEEDGDF

Query:  DED
        DED
Subjt:  DED

A0A6J1IWX9 DNA topoisomerase 2

1.9e-28

55.67

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Query:  DVSAMETEGP-----AEKKEPSKRAAATKKTSVTSAQTS------------------------QAAANGKTTK-----PPAA-------------GKNLG
        +VSAMETE P     A+KKEPSKRAAA KKT+  SAQ S                        +AAAN KTTK      P A              +N G
Subjt:  DVSAMETEGP-----AEKKEPSKRAAATKKTSVTSAQTS------------------------QAAANGKTTK-----PPAA-------------GKNLG

Query:  IMPEKKVRKIRASPFNKKSGSILG------TVSLEGDGNEGKMMGSASSETT-EETAGYPLERGRSQRSNRTQVRYVVSDSDSEQPDAEDSDFEEEDGDF
        I PEKKVRKIR SPFNKKSGS+LG         +E  GNEGKMMGSASSETT EE A  PL RGRSQR+NRTQVRYVVSDSDSE P  EDSDF+EE  D 
Subjt:  IMPEKKVRKIRASPFNKKSGSILG------TVSLEGDGNEGKMMGSASSETT-EETAGYPLERGRSQRSNRTQVRYVVSDSDSEQPDAEDSDFEEEDGDF

Query:  DED
        DED
Subjt:  DED

A0A6J1J555 DNA topoisomerase 2

1.9e-28

55.67

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Query:  DVSAMETEGP-----AEKKEPSKRAAATKKTSVTSAQTS------------------------QAAANGKTTK-----PPAA-------------GKNLG
        +VSAMETE P     A+KKEPSKRAAA KKT+  SAQ S                        +AAAN KTTK      P A              +N G
Subjt:  DVSAMETEGP-----AEKKEPSKRAAATKKTSVTSAQTS------------------------QAAANGKTTK-----PPAA-------------GKNLG

Query:  IMPEKKVRKIRASPFNKKSGSILG------TVSLEGDGNEGKMMGSASSETT-EETAGYPLERGRSQRSNRTQVRYVVSDSDSEQPDAEDSDFEEEDGDF
        I PEKKVRKIR SPFNKKSGS+LG         +E  GNEGKMMGSASSETT EE A  PL RGRSQR+NRTQVRYVVSDSDSE P  EDSDF+EE  D 
Subjt:  IMPEKKVRKIRASPFNKKSGSILG------TVSLEGDGNEGKMMGSASSETT-EETAGYPLERGRSQRSNRTQVRYVVSDSDSEQPDAEDSDFEEEDGDF

Query:  DED
        DED
Subjt:  DED

SwissProt top hits

e value

%identity

Alignment

O24308 DNA topoisomerase 2

3.4e-11

42.28

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Query:  AMETEGPAEKKEPSKRAAATKKTSVTSAQTSQAAANGKTTKPPAAGKNLGIMPEKKVRKIRASPFNKKSGSILG------TVSLEGDGNEGKMMGSASSE
        A +    A  K P+K  AA KK SV    T Q+A     T      +  G  PEKKVRK+R SPFNKKSGSILG       +S   D + G    +  SE
Subjt:  AMETEGPAEKKEPSKRAAATKKTSVTSAQTSQAAANGKTTKPPAAGKNLGIMPEKKVRKIRASPFNKKSGSILG------TVSLEGDGNEGKMMGSASSE

Query:  TTEETAGYPLERGRSQRSNRTQVRYVVSDSDSEQ---PDAEDSDFEEED
                   R R QR+NRTQ++Y +S+S+SE+    DAE SDFEE+D
Subjt:  TTEETAGYPLERGRSQRSNRTQVRYVVSDSDSEQ---PDAEDSDFEEED

P30182 DNA topoisomerase 2

1.5e-06

35.97

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Query:  AEKKEPSKRAAATKKTSVTSAQTSQAAANGKTTKPPAAGKNLGIMPEKKVRKIRASPFNKKSGSILGTVSLEGDGNEGKMMGSASSETTEETAGYPLERG
        A  K+  ++ AATK     +A   +    GK T        +G+ PEKKVRK+R+SPFNKKS S++    L  +  E      A + ++E++ G      
Subjt:  AEKKEPSKRAAATKKTSVTSAQTSQAAANGKTTKPPAAGKNLGIMPEKKVRKIRASPFNKKSGSILGTVSLEGDGNEGKMMGSASSETTEETAGYPLERG

Query:  RSQRSNRTQVRYVVSDSDSEQPDAEDSDFEEEDGDFDED
        R QR+NR ++ YV+SDS+SE   A DS+F++ + D D++
Subjt:  RSQRSNRTQVRYVVSDSDSEQPDAEDSDFEEEDGDFDED

Arabidopsis top hits

e value

%identity

Alignment

AT3G23890.1 topoisomerase II

1.0e-07

35.97

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Query:  AEKKEPSKRAAATKKTSVTSAQTSQAAANGKTTKPPAAGKNLGIMPEKKVRKIRASPFNKKSGSILGTVSLEGDGNEGKMMGSASSETTEETAGYPLERG
        A  K+  ++ AATK     +A   +    GK T        +G+ PEKKVRK+R+SPFNKKS S++    L  +  E      A + ++E++ G      
Subjt:  AEKKEPSKRAAATKKTSVTSAQTSQAAANGKTTKPPAAGKNLGIMPEKKVRKIRASPFNKKSGSILGTVSLEGDGNEGKMMGSASSETTEETAGYPLERG

Query:  RSQRSNRTQVRYVVSDSDSEQPDAEDSDFEEEDGDFDED
        R QR+NR ++ YV+SDS+SE   A DS+F++ + D D++
Subjt:  RSQRSNRTQVRYVVSDSDSEQPDAEDSDFEEEDGDFDED

AT3G23890.2 topoisomerase II

1.0e-07

35.97

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Query:  AEKKEPSKRAAATKKTSVTSAQTSQAAANGKTTKPPAAGKNLGIMPEKKVRKIRASPFNKKSGSILGTVSLEGDGNEGKMMGSASSETTEETAGYPLERG
        A  K+  ++ AATK     +A   +    GK T        +G+ PEKKVRK+R+SPFNKKS S++    L  +  E      A + ++E++ G      
Subjt:  AEKKEPSKRAAATKKTSVTSAQTSQAAANGKTTKPPAAGKNLGIMPEKKVRKIRASPFNKKSGSILGTVSLEGDGNEGKMMGSASSETTEETAGYPLERG

Query:  RSQRSNRTQVRYVVSDSDSEQPDAEDSDFEEEDGDFDED
        R QR+NR ++ YV+SDS+SE   A DS+F++ + D D++
Subjt:  RSQRSNRTQVRYVVSDSDSEQPDAEDSDFEEEDGDFDED

Sequences

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CDS sequence

Show/hide CDS sequence

ATGCTGTGTGTACCCTTGATTATACAACTTGATGATGTTTCAGCCATGGAAACCGAAGGACCAGCCGAGAAGAAAGAACCCAGCAAGAGAGCAGCTGCCACGAAGAAAAC
TAGTGTAACTTCTGCTCAGACTTCCCAGGCAGCTGCAAATGGCAAAACAACCAAGCCCCCTGCAGCAGGGAAGAACCTCGGGATCATGCCTGAGAAGAAAGTGAGGAAGA
TAAGGGCATCTCCTTTCAACAAGAAAAGTGGATCCATCCTTGGAACAGTTAGTTTAGAAGGAGATGGAAATGAAGGGAAGATGATGGGATCTGCTTCTTCGGAGACGACG
GAAGAAACCGCTGGATATCCACTGGAGAGAGGAAGATCACAGAGGTCTAACAGAACCCAGGTGAGATATGTGGTTAGTGATTCAGACAGCGAGCAGCCAGATGCTGAGGA
TTCTGACTTTGAAGAAGAAGATGGAGACTTTGATGAAGATTGA

mRNA sequence

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Protein sequence

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MLCVPLIIQLDDVSAMETEGPAEKKEPSKRAAATKKTSVTSAQTSQAAANGKTTKPPAAGKNLGIMPEKKVRKIRASPFNKKSGSILGTVSLEGDGNEGKMMGSASSETT
EETAGYPLERGRSQRSNRTQVRYVVSDSDSEQPDAEDSDFEEEDGDFDED

Sed0015505 (gene) of Chayote v1 genome