CuGenDBv2

Gene ID	Sed0023051
Organism	Sechium edule (Chayote v1)
Description	BRCA1-associated RING domain protein 1
Genome location	LG05:837335..842955
RNA-Seq Expression	Sed0023051
Synteny	Sed0023051
Gene Ontology terms	GO:0000724 - double-strand break repair via homologous recombination (biological process) GO:0016567 - protein ubiquitination (biological process) GO:0035066 - positive regulation of histone acetylation (biological process) GO:0035067 - negative regulation of histone acetylation (biological process) GO:0045717 - negative regulation of fatty acid biosynthetic process (biological process) GO:0045944 - positive regulation of transcription by RNA polymerase II (biological process) GO:0005886 - plasma membrane (cellular component) GO:0031436 - BRCA1-BARD1 complex (cellular component) GO:0070531 - BRCA1-A complex (cellular component) GO:0046872 - metal ion binding (molecular function) GO:0004842 - ubiquitin-protein transferase activity (molecular function)
InterPro domains	IPR036420 - BRCT domain superfamily IPR034732 - Extended PHD (ePHD) domain IPR031099 - BRCA1-associated IPR013083 - Zinc finger, RING/FYVE/PHD-type IPR001965 - Zinc finger, PHD-type IPR001357 - BRCT domain

Homology

Show/hide homology

GenBank top hits

e value

%identity

Alignment

KAG6571541.1 BRCA1-associated RING domain protein 1, partial [Cucurbita argyrosperma subsp. sororia]

9.7e-255

73.93

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Query:  MRPASFMDKMVSIYKNLDATFSTNMPKLVSSVGIGVALEQSRFSQSVPFAASNCKEF-----------ENLYMEGRKHSCERLEDCRMPHESQVDQLSAE
        +RPA FMDKMVSIY++LDATF+TNM KLVS+V +G  +E+SRF QS P A  NCKEF           ENL +E RK S  R EDCRMP  SQ DQLSA 
Subjt:  MRPASFMDKMVSIYKNLDATFSTNMPKLVSSVGIGVALEQSRFSQSVPFAASNCKEF-----------ENLYMEGRKHSCERLEDCRMPHESQVDQLSAE

Query:  SRPPFGDGKVSDDSSDEYRRHGFKSASDRISIITSAGENNLELSKCTSSAVEEEGHLRSLKRQNLDYGPLKSGISGADHIHPPVSELGNSQTSNSEIEHK
        S PPFGDGKVSDDSSDEYR HG K+ SDR S+I +A +  L+LSKCTSS  EEEGHLR  KRQ LDYG LKSG S  D  HPP SELGNS+TSNSE+EHK
Subjt:  SRPPFGDGKVSDDSSDEYRRHGFKSASDRISIITSAGENNLELSKCTSSAVEEEGHLRSLKRQNLDYGPLKSGISGADHIHPPVSELGNSQTSNSEIEHK

Query:  SRVNIACNMPIADADNAIVRNAKCAFCQSSQVTVDTGPILHYMNGTLVVEVEAANPNVIHVHKLCVDWTPQVYYQDNVIQNLKAEVARGSKLKCNKCGVK
        S+V IA N+P+ADA++AIVRNAKCAFCQSS+VT DTGP+LHY+NG+LVV VEAANPNVIH HKLCVDW PQ YYQ + + NLK+EVARGSKLKC+KCG+K
Subjt:  SRVNIACNMPIADADNAIVRNAKCAFCQSSQVTVDTGPILHYMNGTLVVEVEAANPNVIHVHKLCVDWTPQVYYQDNVIQNLKAEVARGSKLKCNKCGVK

Query:  GAALGCYLKSCQKSYHVPCALEIEECRWDMVNFLLLCPSHSSTRFPDERSKPR------------NQQDSSNWKPSPDGVNKWIFCPSALSAGERIILVK
        GAALGCY KSCQKSYHVPCALEIEECRWD  NFLLLCPSHSS RFPDERSK R            NQQDS+NW   PDGV KW FC SALSA ER ILVK
Subjt:  GAALGCYLKSCQKSYHVPCALEIEECRWDMVNFLLLCPSHSSTRFPDERSKPR------------NQQDSSNWKPSPDGVNKWIFCPSALSAGERIILVK

Query:  FANISGAAVSKFWKPDVTHVIASTDANGACTRTYKVLMGILNGAWILNMDWVKACMKEKLPLSEEAYEIALDNYRCIDGPKSGRLRALYKASKLFTGLSF
        FA ISGA VSKFWKPDVTHVIAST  NGACTRTYKVLMGILNG WILNMDWVKACMKE+ PL+EE YEIALDNY CIDGPKSGRLR L  A KLFTGLSF
Subjt:  FANISGAAVSKFWKPDVTHVIASTDANGACTRTYKVLMGILNGAWILNMDWVKACMKEKLPLSEEAYEIALDNYRCIDGPKSGRLRALYKASKLFTGLSF

Query:  HFTDGFSSAYKEDLQDLVIAAGGRILEREERAAPSC-NDPAAALKVLVVYNLDFPEGCKVEDEVSILWQRLNDAEEIAAKIEAQVIGHTWLLESIASGNL
        +FT  F  AY+EDLQDLVI AGG ILE EE A PSC +D AAA KVLVVYNLD P GCKV +EVSILW+RLNDAE IAAK+ AQVIGHTWL+ESIA+GNL
Subjt:  HFTDGFSSAYKEDLQDLVIAAGGRILEREERAAPSC-NDPAAALKVLVVYNLDFPEGCKVEDEVSILWQRLNDAEEIAAKIEAQVIGHTWLLESIASGNL

Query:  QPFFSC
        QPF SC
Subjt:  QPFFSC

XP_022963583.1 BRCA1-associated RING domain protein 1 [Cucurbita moschata]

4.3e-255

74.09

Show/hide

Query:  MRPASFMDKMVSIYKNLDATFSTNMPKLVSSVGIGVALEQSRFSQSVPFAASNCKEF-----------ENLYMEGRKHSCERLEDCRMPHESQVDQLSAE
        +RPA FMDKMVSIY++LDATF+TNM KLVS+V +G  +E+SRF QS P A  NCKEF           ENL +E RK S  R EDCRMP  SQ DQLSA 
Subjt:  MRPASFMDKMVSIYKNLDATFSTNMPKLVSSVGIGVALEQSRFSQSVPFAASNCKEF-----------ENLYMEGRKHSCERLEDCRMPHESQVDQLSAE

Query:  SRPPFGDGKVSDDSSDEYRRHGFKSASDRISIITSAGENNLELSKCTSSAVEEEGHLRSLKRQNLDYGPLKSGISGADHIHPPVSELGNSQTSNSEIEHK
        S PPFGDGKVSDDSSDEYR HG K+ SDR S+I +A +  L+LSKCTSS  EEEGHLR  KRQ LDYG LKSG S  D  HPP SELGNS+TSNSE+EHK
Subjt:  SRPPFGDGKVSDDSSDEYRRHGFKSASDRISIITSAGENNLELSKCTSSAVEEEGHLRSLKRQNLDYGPLKSGISGADHIHPPVSELGNSQTSNSEIEHK

Query:  SRVNIACNMPIADADNAIVRNAKCAFCQSSQVTVDTGPILHYMNGTLVVEVEAANPNVIHVHKLCVDWTPQVYYQDNVIQNLKAEVARGSKLKCNKCGVK
        S+V IA N+P+ADA++AIVRNAKCAFCQSS+VT DTGP+LHY+NG+LVV VEAANPNVIH HKLCVDW PQ YYQ + + NLK+EVARGSKLKC+KCG+K
Subjt:  SRVNIACNMPIADADNAIVRNAKCAFCQSSQVTVDTGPILHYMNGTLVVEVEAANPNVIHVHKLCVDWTPQVYYQDNVIQNLKAEVARGSKLKCNKCGVK

Query:  GAALGCYLKSCQKSYHVPCALEIEECRWDMVNFLLLCPSHSSTRFPDERSKPR------------NQQDSSNWKPSPDGVNKWIFCPSALSAGERIILVK
        GAALGCY KSCQKSYHVPCALEIEECRWD  NFLLLCPSHSS RFPDERSK R            NQQDS+NW   PDGV KW FC SALSA ER ILVK
Subjt:  GAALGCYLKSCQKSYHVPCALEIEECRWDMVNFLLLCPSHSSTRFPDERSKPR------------NQQDSSNWKPSPDGVNKWIFCPSALSAGERIILVK

Query:  FANISGAAVSKFWKPDVTHVIASTDANGACTRTYKVLMGILNGAWILNMDWVKACMKEKLPLSEEAYEIALDNYRCIDGPKSGRLRALYKASKLFTGLSF
        FA ISGA VSKFWKPDVTHVIAST  NGACTRTYKVLMGILNG WILNMDWVKACMKE+ PL+EE YEIALDNY CIDGPKSGRLR L  A KLFTGLSF
Subjt:  FANISGAAVSKFWKPDVTHVIASTDANGACTRTYKVLMGILNGAWILNMDWVKACMKEKLPLSEEAYEIALDNYRCIDGPKSGRLRALYKASKLFTGLSF

Query:  HFTDGFSSAYKEDLQDLVIAAGGRILEREERAAPSC-NDPAAALKVLVVYNLDFPEGCKVEDEVSILWQRLNDAEEIAAKIEAQVIGHTWLLESIASGNL
        +FT  F  AY+EDLQDLVI AGG ILE EE A PSC +D AAA KVLVVYNLD P GCKV +EVSILWQRLNDAE IAAK+ AQVIGHTWL+ESIA+GNL
Subjt:  HFTDGFSSAYKEDLQDLVIAAGGRILEREERAAPSC-NDPAAALKVLVVYNLDFPEGCKVEDEVSILWQRLNDAEEIAAKIEAQVIGHTWLLESIASGNL

Query:  QPFFSC
        QPF SC
Subjt:  QPFFSC

XP_022967204.1 BRCA1-associated RING domain protein 1 [Cucurbita maxima]

9.0e-253

73.43

Show/hide

Query:  MRPASFMDKMVSIYKNLDATFSTNMPKLVSSVGIGVALEQSRFSQSVPFAASNCKEF-----------ENLYMEGRKHSCERLEDCRMPHESQVDQLSAE
        +RPA FMDKMVSIY++LDATF+TNM KLVS+V +G  +E+SRF QS P A  NCKEF           ENL +E RK S  R EDCRMP  SQ DQLSA 
Subjt:  MRPASFMDKMVSIYKNLDATFSTNMPKLVSSVGIGVALEQSRFSQSVPFAASNCKEF-----------ENLYMEGRKHSCERLEDCRMPHESQVDQLSAE

Query:  SRPPFGDGKVSDDSSDEYRRHGFKSASDRISIITSAGENNLELSKCTSSAVEEEGHLRSLKRQNLDYGPLKSGISGADHIHPPVSELGNSQTSNSEIEHK
        S PPFGDGKVSDDSSDEYR HG K+ASDR S+I +A +  L+LSKCTSS  EEEGHLR  KRQ LDYG LKSG S  D  HPP SELGNS+TSNSE+E K
Subjt:  SRPPFGDGKVSDDSSDEYRRHGFKSASDRISIITSAGENNLELSKCTSSAVEEEGHLRSLKRQNLDYGPLKSGISGADHIHPPVSELGNSQTSNSEIEHK

Query:  SRVNIACNMPIADADNAIVRNAKCAFCQSSQVTVDTGPILHYMNGTLVVEVEAANPNVIHVHKLCVDWTPQVYYQDNVIQNLKAEVARGSKLKCNKCGVK
        S+V IA N+P+ DA++AIVRNAKCAFCQSS+VT DTGP+LHY+NG+LVV VEA NPNVIH HKLCVDW PQ YYQ + + NLK+EVARGSKLKC+KCG+K
Subjt:  SRVNIACNMPIADADNAIVRNAKCAFCQSSQVTVDTGPILHYMNGTLVVEVEAANPNVIHVHKLCVDWTPQVYYQDNVIQNLKAEVARGSKLKCNKCGVK

Query:  GAALGCYLKSCQKSYHVPCALEIEECRWDMVNFLLLCPSHSSTRFPDERSKPR------------NQQDSSNWKPSPDGVNKWIFCPSALSAGERIILVK
        GAALGCY KSCQKSYHVPCALEIEECRWD  NFLLLCPSHSS RFPDERSK R            NQQDS+NW   PDGV KW FC SALSA ER IL+K
Subjt:  GAALGCYLKSCQKSYHVPCALEIEECRWDMVNFLLLCPSHSSTRFPDERSKPR------------NQQDSSNWKPSPDGVNKWIFCPSALSAGERIILVK

Query:  FANISGAAVSKFWKPDVTHVIASTDANGACTRTYKVLMGILNGAWILNMDWVKACMKEKLPLSEEAYEIALDNYRCIDGPKSGRLRALYKASKLFTGLSF
        FA ISGA VSKFWKPDVTHVIAST  NGACTRTYKVLMGILNG WILNMDWVKACMKE+ PL+EE YEIALDNY CIDGPKSGRLR L  A KLFTGLSF
Subjt:  FANISGAAVSKFWKPDVTHVIASTDANGACTRTYKVLMGILNGAWILNMDWVKACMKEKLPLSEEAYEIALDNYRCIDGPKSGRLRALYKASKLFTGLSF

Query:  HFTDGFSSAYKEDLQDLVIAAGGRILEREERAAPSC-NDPAAALKVLVVYNLDFPEGCKVEDEVSILWQRLNDAEEIAAKIEAQVIGHTWLLESIASGNL
        +FT  F  AY+EDLQDLVI AGG ILE EE A PSC +D A+A KVLVVYNLD P GCKV +EVSILWQRLNDAE IAAK+ AQVIGHTWL+ESIA+GNL
Subjt:  HFTDGFSSAYKEDLQDLVIAAGGRILEREERAAPSC-NDPAAALKVLVVYNLDFPEGCKVEDEVSILWQRLNDAEEIAAKIEAQVIGHTWLLESIASGNL

Query:  QPFFSC
        QPF SC
Subjt:  QPFFSC

XP_023554232.1 BRCA1-associated RING domain protein 1 [Cucurbita pepo subsp. pepo]

1.2e-252

73.6

Show/hide

Query:  MRPASFMDKMVSIYKNLDATFSTNMPKLVSSVGIGVALEQSRFSQSVPFAASNCKEF-----------ENLYMEGRKHSCERLEDCRMPHESQVDQLSAE
        +RPA FMDKMVSIY++LDATF+TNM KLVS+V +G  +E+SRF QS P A  NCKEF           ENL +E RK S  R EDCRMP  SQ DQLSA 
Subjt:  MRPASFMDKMVSIYKNLDATFSTNMPKLVSSVGIGVALEQSRFSQSVPFAASNCKEF-----------ENLYMEGRKHSCERLEDCRMPHESQVDQLSAE

Query:  SRPPFGDGKVSDDSSDEYRRHGFKSASDRISIITSAGENNLELSKCTSSAVEEEGHLRSLKRQNLDYGPLKSGISGADHIHPPVSELGNSQTSNSEIEHK
        S PPFGDGKVSDDSSDEYR HG K+ SDR S+I +A +  L+LSKCTSS  EEEGH R  KRQ  DYG LKSG S  D  HPP SELGNS+TSNSE+EHK
Subjt:  SRPPFGDGKVSDDSSDEYRRHGFKSASDRISIITSAGENNLELSKCTSSAVEEEGHLRSLKRQNLDYGPLKSGISGADHIHPPVSELGNSQTSNSEIEHK

Query:  SRVNIACNMPIADADNAIVRNAKCAFCQSSQVTVDTGPILHYMNGTLVVEVEAANPNVIHVHKLCVDWTPQVYYQDNVIQNLKAEVARGSKLKCNKCGVK
        S+V IA N+P+ADA++AIVRNAKCAFCQSS+VT DTGP+LHY+NG+LVV VEAANPNVIH HKLCVDW PQ YYQ + + NLK+EVARGSKLKC+KCG+K
Subjt:  SRVNIACNMPIADADNAIVRNAKCAFCQSSQVTVDTGPILHYMNGTLVVEVEAANPNVIHVHKLCVDWTPQVYYQDNVIQNLKAEVARGSKLKCNKCGVK

Query:  GAALGCYLKSCQKSYHVPCALEIEECRWDMVNFLLLCPSHSSTRFPDERSKPR------------NQQDSSNWKPSPDGVNKWIFCPSALSAGERIILVK
        GAALGCY KSCQKSYHVPCALEIEECRWD  NFLLLCPSHSS RFPDERSK R            NQQDS+NW    DGV KW FC SALSA ER ILVK
Subjt:  GAALGCYLKSCQKSYHVPCALEIEECRWDMVNFLLLCPSHSSTRFPDERSKPR------------NQQDSSNWKPSPDGVNKWIFCPSALSAGERIILVK

Query:  FANISGAAVSKFWKPDVTHVIASTDANGACTRTYKVLMGILNGAWILNMDWVKACMKEKLPLSEEAYEIALDNYRCIDGPKSGRLRALYKASKLFTGLSF
        FA ISGA VSKFWKPDVTHVIAST  NGACTRTYKVLMGILNG WILNMDWVKACMKE+ PL+EE YEIALDNY C DGPKSGRLR L  A KLFTGLSF
Subjt:  FANISGAAVSKFWKPDVTHVIASTDANGACTRTYKVLMGILNGAWILNMDWVKACMKEKLPLSEEAYEIALDNYRCIDGPKSGRLRALYKASKLFTGLSF

Query:  HFTDGFSSAYKEDLQDLVIAAGGRILEREERAAPSC-NDPAAALKVLVVYNLDFPEGCKVEDEVSILWQRLNDAEEIAAKIEAQVIGHTWLLESIASGNL
        +FT  F  AY+EDLQDLVI AGG ILE EE AAPSC +D AAA KVLVVYNLD P GCKV +EVSILWQRLNDAE IAAK+ AQVIGHTWL+ESIA+GNL
Subjt:  HFTDGFSSAYKEDLQDLVIAAGGRILEREERAAPSC-NDPAAALKVLVVYNLDFPEGCKVEDEVSILWQRLNDAEEIAAKIEAQVIGHTWLLESIASGNL

Query:  QPFFSC
        QPF SC
Subjt:  QPFFSC

XP_038887493.1 BRCA1-associated RING domain protein 1 isoform X1 [Benincasa hispida]

8.8e-248

73.06

Show/hide

Query:  MRPASFMDKMVSIYKNLDATFSTNMPKLVSSVGIGVALEQSRFSQSVPFAASNCKEF-----------ENLYMEGRKHSCERLEDCRMPHESQVDQLSAE
        MRPA FMDKMVSIY++LDATFSTNM KLVS+  +G  +EQSRF QSV +  +NCKEF           ENL ++GRK    R EDCRMP  SQ DQLSA 
Subjt:  MRPASFMDKMVSIYKNLDATFSTNMPKLVSSVGIGVALEQSRFSQSVPFAASNCKEF-----------ENLYMEGRKHSCERLEDCRMPHESQVDQLSAE

Query:  SRPPFGDGKVSDDSSDEYRRHGFKSASDRISIITSAGENNLELSKCTSSAVEEEGHLRSLKRQNLDYGPLKSGISGADHIHPPVSELGNSQTSNSEIEHK
        S P FGDGKVSDDSSDE R HG K+ SDRIS+IT+A +N L+LSKC SSA EE GHLR LKRQ L+Y  LK GIS AD  HPPVSE GNS+TSNSE+EHK
Subjt:  SRPPFGDGKVSDDSSDEYRRHGFKSASDRISIITSAGENNLELSKCTSSAVEEEGHLRSLKRQNLDYGPLKSGISGADHIHPPVSELGNSQTSNSEIEHK

Query:  SRVNIACNMPIADADNAIVRNAKCAFCQSSQVTVDTGPILHYMNGTLVVEVEAANPNVIHVHKLCVDWTPQVYYQDNVIQNLKAEVARGSKLKCNKCGVK
        ++V +A +MP+ADAD AIVRN KCAFCQSS+VT DTGP LHYMNG+LV  VEAANPNVIHVHKLCVDW PQ YYQ + + NLKAEVARGSKLKC KCG+K
Subjt:  SRVNIACNMPIADADNAIVRNAKCAFCQSSQVTVDTGPILHYMNGTLVVEVEAANPNVIHVHKLCVDWTPQVYYQDNVIQNLKAEVARGSKLKCNKCGVK

Query:  GAALGCYLKSCQKSYHVPCALEIEECRWDMVNFLLLCPSHSSTRFPDERSKPR------------NQQDSSNWKPSPDGVNKWIFCPSALSAGERIILVK
        GAALGCYLKSC +SYHVPCALEIEECRWDM NFLLLCPSH+STRFPDERSKPR            NQQD SNW   PDGVNKW FC SALS  ER ILVK
Subjt:  GAALGCYLKSCQKSYHVPCALEIEECRWDMVNFLLLCPSHSSTRFPDERSKPR------------NQQDSSNWKPSPDGVNKWIFCPSALSAGERIILVK

Query:  FANISGAAVSKFWKPDVTHVIASTDANGACTRTYKVLMGILNGAWILNMDWVKACMKEKLPLSEEAYEIALDNYRCIDGPKSGRLRALYKASKLFTGLSF
        FA +SGA VSK WKPDVTHVIASTD NGACTRTYKVLMGILNG WILNMDWVKACMKEK PL+EEAYEIALDNY C DGPKSGRLR L K  KLF GLSF
Subjt:  FANISGAAVSKFWKPDVTHVIASTDANGACTRTYKVLMGILNGAWILNMDWVKACMKEKLPLSEEAYEIALDNYRCIDGPKSGRLRALYKASKLFTGLSF

Query:  HFTDGFSSAYKEDLQDLVIAAGGRILEREERAAPSCNDPAAALKVLVVYNLDFPEGCKVEDEVSILWQRLNDAEEIAAKIEAQVIGHTWLLESIASGNLQ
        +FT  F  AY+EDLQDL+I AGG +LE E+ AA SCN  AA  KVLVVYNLD P GCKV +EVSILWQR+N+AE IAAK+ AQVIGHTWL+ESIA+ NLQ
Subjt:  HFTDGFSSAYKEDLQDLVIAAGGRILEREERAAPSCNDPAAALKVLVVYNLDFPEGCKVEDEVSILWQRLNDAEEIAAKIEAQVIGHTWLLESIASGNLQ

Query:  PFFSC
        PF SC
Subjt:  PFFSC

TrEMBL top hits

e value

%identity

Alignment

A0A0A0LDW6 Uncharacterized protein

1.2e-245

71.9

Show/hide

Query:  MRPASFMDKMVSIYKNLDATFSTNMPKLVSSVGIGVALEQSRFSQSVPFAASNCKEFE-----------NLYMEGRKHSCERLEDCRMPHESQVDQLSAE
        MRPA FMDKMVSIY++LDATFSTNM KLVS+V +G A+EQSRF QSV + A+NCKEFE           +L +EGRK    R EDC MP  SQ DQLS+ 
Subjt:  MRPASFMDKMVSIYKNLDATFSTNMPKLVSSVGIGVALEQSRFSQSVPFAASNCKEFE-----------NLYMEGRKHSCERLEDCRMPHESQVDQLSAE

Query:  SRPPFGDGKVSDDSSDEYRRHGFKSASDRISIITSAGENNLELSKCTSSAVEEEGHLRSLKRQNLDYGPLKSGISGADHIHPPVSELGNSQTSNSEIEHK
        S P FGDGKVSDDSSDEYR HG K+ SD IS+ITSA +  L+LSKCTSSA EEEGHLR LKRQ L+YG LK  IS AD  HPPVSE GNS+TSNS +EHK
Subjt:  SRPPFGDGKVSDDSSDEYRRHGFKSASDRISIITSAGENNLELSKCTSSAVEEEGHLRSLKRQNLDYGPLKSGISGADHIHPPVSELGNSQTSNSEIEHK

Query:  SRVNIACNMPIADADNAIVRNAKCAFCQSSQVTVDTGPILHYMNGTLVVEVEAANPNVIHVHKLCVDWTPQVYYQDNVIQNLKAEVARGSKLKCNKCGVK
        S+V  A +MP+ADAD+ IVRN KCAFCQSS+VT DTG +LHYMNG LV  VEAA+PNVIHVHKLCV+W PQ Y+Q + + NLKAEVARGSKLKC+KCG+K
Subjt:  SRVNIACNMPIADADNAIVRNAKCAFCQSSQVTVDTGPILHYMNGTLVVEVEAANPNVIHVHKLCVDWTPQVYYQDNVIQNLKAEVARGSKLKCNKCGVK

Query:  GAALGCYLKSCQKSYHVPCALEIEECRWDMVNFLLLCPSHSSTRFPDERSKPR------------NQQDSSNWKPSPDGVNKWIFCPSALSAGERIILVK
        GAALGCYL+SCQKSYHVPCALEI+ECRWDM NFL+LCPSH+S RFPDERSKPR            NQ+D SNW  + DGVNKW FC SALSA ER ILVK
Subjt:  GAALGCYLKSCQKSYHVPCALEIEECRWDMVNFLLLCPSHSSTRFPDERSKPR------------NQQDSSNWKPSPDGVNKWIFCPSALSAGERIILVK

Query:  FANISGAAVSKFWKPDVTHVIASTDANGACTRTYKVLMGILNGAWILNMDWVKACMKEKLPLSEEAYEIALDNYRCIDGPKSGRLRALYKASKLFTGLSF
        FA ++GA VSK WKPDVTHVIASTD NGACTRTYKVLMGILNG WILNMDWVK CMKEK PL+EEAYEIALDNY C DGPK+GRLR L K  KLF GLSF
Subjt:  FANISGAAVSKFWKPDVTHVIASTDANGACTRTYKVLMGILNGAWILNMDWVKACMKEKLPLSEEAYEIALDNYRCIDGPKSGRLRALYKASKLFTGLSF

Query:  HFTDGFSSAYKEDLQDLVIAAGGRILEREERAAPSCNDPAAALKVLVVYNLDFPEGCKVEDEVSILWQRLNDAEEIAAKIEAQVIGHTWLLESIASGNLQ
        +FT  F  AY+EDLQDLVI AGG +LE EE AA S ND AA  KV+VVYNLD P GCKV +EVSILWQR+N+AE IAAK+ AQVIGHTWL+ESIA G+LQ
Subjt:  HFTDGFSSAYKEDLQDLVIAAGGRILEREERAAPSCNDPAAALKVLVVYNLDFPEGCKVEDEVSILWQRLNDAEEIAAKIEAQVIGHTWLLESIASGNLQ

Query:  PFFSC
        PF SC
Subjt:  PFFSC

A0A1S3BI76 BRCA1-associated RING domain protein 1 isoform X1

4.9e-244

71.57

Show/hide

Query:  MRPASFMDKMVSIYKNLDATFSTNMPKLVSSVGIGVALEQSRFSQSVPFAASNCKEFENLYM-----------EGRKHSCERLEDCRMPHESQVDQLSAE
        MRPA FMDKMVSIY++LDATFSTNM KLVS+V +G A+EQSRF QSV + A+NCKEFE   M           EG K    R EDC MP  SQ DQLS+ 
Subjt:  MRPASFMDKMVSIYKNLDATFSTNMPKLVSSVGIGVALEQSRFSQSVPFAASNCKEFENLYM-----------EGRKHSCERLEDCRMPHESQVDQLSAE

Query:  SRPPFGDGKVSDDSSDEYRRHGFKSASDRISIITSAGENNLELSKCTSSAVEEEGHLRSLKRQNLDYGPLKSGISGADHIHPPVSELGNSQTSNSEIEHK
        S P FGDGKVSDDSSDEYR HG K+ SD  SIIT+A +  L+LSKCTSSA EEEGHLR LKRQ L+YG LK GIS AD  HPPVSE GNS+TSNS +EHK
Subjt:  SRPPFGDGKVSDDSSDEYRRHGFKSASDRISIITSAGENNLELSKCTSSAVEEEGHLRSLKRQNLDYGPLKSGISGADHIHPPVSELGNSQTSNSEIEHK

Query:  SRVNIACNMPIADADNAIVRNAKCAFCQSSQVTVDTGPILHYMNGTLVVEVEAANPNVIHVHKLCVDWTPQVYYQDNVIQNLKAEVARGSKLKCNKCGVK
        S++ IA +MP+ADAD+ IVRN KCAFCQSS+VT DTG +LHY+NG LV  VEAA+PNVIHVHKLCV+W PQ Y+Q + + NLKAEVARGSKLKC+KCG+K
Subjt:  SRVNIACNMPIADADNAIVRNAKCAFCQSSQVTVDTGPILHYMNGTLVVEVEAANPNVIHVHKLCVDWTPQVYYQDNVIQNLKAEVARGSKLKCNKCGVK

Query:  GAALGCYLKSCQKSYHVPCALEIEECRWDMVNFLLLCPSHSSTRFPDERSKPR------------NQQDSSNWKPSPDGVNKWIFCPSALSAGERIILVK
        GAALGCYL+SCQKSYHVPCALEI+ECRWDM NFLLLCPSH+S RFPDERSKPR            NQ+  SNW    DGVNKW FC SALSA ER ILVK
Subjt:  GAALGCYLKSCQKSYHVPCALEIEECRWDMVNFLLLCPSHSSTRFPDERSKPR------------NQQDSSNWKPSPDGVNKWIFCPSALSAGERIILVK

Query:  FANISGAAVSKFWKPDVTHVIASTDANGACTRTYKVLMGILNGAWILNMDWVKACMKEKLPLSEEAYEIALDNYRCIDGPKSGRLRALYKASKLFTGLSF
        FA + GA VSK WKPDVTHVIASTD NGACTRTYKVLMGILNG WILNMDWVK C+KEK PL+EEAYEIALDNY C DGPK+GRLR L K  KLF GLSF
Subjt:  FANISGAAVSKFWKPDVTHVIASTDANGACTRTYKVLMGILNGAWILNMDWVKACMKEKLPLSEEAYEIALDNYRCIDGPKSGRLRALYKASKLFTGLSF

Query:  HFTDGFSSAYKEDLQDLVIAAGGRILEREERAAPSCNDPAAALKVLVVYNLDFPEGCKVEDEVSILWQRLNDAEEIAAKIEAQVIGHTWLLESIASGNLQ
        +FT  F  AY+EDLQDLVI AGG +LE EE AA SCN  AA  KVLVVYNLD P GCKV +EVSILWQR+N+AE IAAK+ AQVIGHTWL+ESIA G+LQ
Subjt:  HFTDGFSSAYKEDLQDLVIAAGGRILEREERAAPSCNDPAAALKVLVVYNLDFPEGCKVEDEVSILWQRLNDAEEIAAKIEAQVIGHTWLLESIASGNLQ

Query:  PFFSC
        PF SC
Subjt:  PFFSC

A0A5A7T711 BRCA1-associated RING domain protein 1 isoform X1

4.9e-244

71.57

Show/hide

Query:  MRPASFMDKMVSIYKNLDATFSTNMPKLVSSVGIGVALEQSRFSQSVPFAASNCKEFENLYM-----------EGRKHSCERLEDCRMPHESQVDQLSAE
        MRPA FMDKMVSIY++LDATFSTNM KLVS+V +G A+EQSRF QSV + A+NCKEFE   M           EG K    R EDC MP  SQ DQLS+ 
Subjt:  MRPASFMDKMVSIYKNLDATFSTNMPKLVSSVGIGVALEQSRFSQSVPFAASNCKEFENLYM-----------EGRKHSCERLEDCRMPHESQVDQLSAE

Query:  SRPPFGDGKVSDDSSDEYRRHGFKSASDRISIITSAGENNLELSKCTSSAVEEEGHLRSLKRQNLDYGPLKSGISGADHIHPPVSELGNSQTSNSEIEHK
        S P FGDGKVSDDSSDEYR HG K+ SD  SIIT+A +  L+LSKCTSSA EEEGHLR LKRQ L+YG LK GIS AD  HPPVSE GNS+TSNS +EHK
Subjt:  SRPPFGDGKVSDDSSDEYRRHGFKSASDRISIITSAGENNLELSKCTSSAVEEEGHLRSLKRQNLDYGPLKSGISGADHIHPPVSELGNSQTSNSEIEHK

Query:  SRVNIACNMPIADADNAIVRNAKCAFCQSSQVTVDTGPILHYMNGTLVVEVEAANPNVIHVHKLCVDWTPQVYYQDNVIQNLKAEVARGSKLKCNKCGVK
        S++ IA +MP+ADAD+ IVRN KCAFCQSS+VT DTG +LHY+NG LV  VEAA+PNVIHVHKLCV+W PQ Y+Q + + NLKAEVARGSKLKC+KCG+K
Subjt:  SRVNIACNMPIADADNAIVRNAKCAFCQSSQVTVDTGPILHYMNGTLVVEVEAANPNVIHVHKLCVDWTPQVYYQDNVIQNLKAEVARGSKLKCNKCGVK

Query:  GAALGCYLKSCQKSYHVPCALEIEECRWDMVNFLLLCPSHSSTRFPDERSKPR------------NQQDSSNWKPSPDGVNKWIFCPSALSAGERIILVK
        GAALGCYL+SCQKSYHVPCALEI+ECRWDM NFLLLCPSH+S RFPDERSKPR            NQ+  SNW    DGVNKW FC SALSA ER ILVK
Subjt:  GAALGCYLKSCQKSYHVPCALEIEECRWDMVNFLLLCPSHSSTRFPDERSKPR------------NQQDSSNWKPSPDGVNKWIFCPSALSAGERIILVK

Query:  FANISGAAVSKFWKPDVTHVIASTDANGACTRTYKVLMGILNGAWILNMDWVKACMKEKLPLSEEAYEIALDNYRCIDGPKSGRLRALYKASKLFTGLSF
        FA + GA VSK WKPDVTHVIASTD NGACTRTYKVLMGILNG WILNMDWVK C+KEK PL+EEAYEIALDNY C DGPK+GRLR L K  KLF GLSF
Subjt:  FANISGAAVSKFWKPDVTHVIASTDANGACTRTYKVLMGILNGAWILNMDWVKACMKEKLPLSEEAYEIALDNYRCIDGPKSGRLRALYKASKLFTGLSF

Query:  HFTDGFSSAYKEDLQDLVIAAGGRILEREERAAPSCNDPAAALKVLVVYNLDFPEGCKVEDEVSILWQRLNDAEEIAAKIEAQVIGHTWLLESIASGNLQ
        +FT  F  AY+EDLQDLVI AGG +LE EE AA SCN  AA  KVLVVYNLD P GCKV +EVSILWQR+N+AE IAAK+ AQVIGHTWL+ESIA G+LQ
Subjt:  HFTDGFSSAYKEDLQDLVIAAGGRILEREERAAPSCNDPAAALKVLVVYNLDFPEGCKVEDEVSILWQRLNDAEEIAAKIEAQVIGHTWLLESIASGNLQ

Query:  PFFSC
        PF SC
Subjt:  PFFSC

A0A6J1HI78 BRCA1-associated RING domain protein 1

2.1e-255

74.09

Show/hide

Query:  MRPASFMDKMVSIYKNLDATFSTNMPKLVSSVGIGVALEQSRFSQSVPFAASNCKEF-----------ENLYMEGRKHSCERLEDCRMPHESQVDQLSAE
        +RPA FMDKMVSIY++LDATF+TNM KLVS+V +G  +E+SRF QS P A  NCKEF           ENL +E RK S  R EDCRMP  SQ DQLSA 
Subjt:  MRPASFMDKMVSIYKNLDATFSTNMPKLVSSVGIGVALEQSRFSQSVPFAASNCKEF-----------ENLYMEGRKHSCERLEDCRMPHESQVDQLSAE

Query:  SRPPFGDGKVSDDSSDEYRRHGFKSASDRISIITSAGENNLELSKCTSSAVEEEGHLRSLKRQNLDYGPLKSGISGADHIHPPVSELGNSQTSNSEIEHK
        S PPFGDGKVSDDSSDEYR HG K+ SDR S+I +A +  L+LSKCTSS  EEEGHLR  KRQ LDYG LKSG S  D  HPP SELGNS+TSNSE+EHK
Subjt:  SRPPFGDGKVSDDSSDEYRRHGFKSASDRISIITSAGENNLELSKCTSSAVEEEGHLRSLKRQNLDYGPLKSGISGADHIHPPVSELGNSQTSNSEIEHK

Query:  SRVNIACNMPIADADNAIVRNAKCAFCQSSQVTVDTGPILHYMNGTLVVEVEAANPNVIHVHKLCVDWTPQVYYQDNVIQNLKAEVARGSKLKCNKCGVK
        S+V IA N+P+ADA++AIVRNAKCAFCQSS+VT DTGP+LHY+NG+LVV VEAANPNVIH HKLCVDW PQ YYQ + + NLK+EVARGSKLKC+KCG+K
Subjt:  SRVNIACNMPIADADNAIVRNAKCAFCQSSQVTVDTGPILHYMNGTLVVEVEAANPNVIHVHKLCVDWTPQVYYQDNVIQNLKAEVARGSKLKCNKCGVK

Query:  GAALGCYLKSCQKSYHVPCALEIEECRWDMVNFLLLCPSHSSTRFPDERSKPR------------NQQDSSNWKPSPDGVNKWIFCPSALSAGERIILVK
        GAALGCY KSCQKSYHVPCALEIEECRWD  NFLLLCPSHSS RFPDERSK R            NQQDS+NW   PDGV KW FC SALSA ER ILVK
Subjt:  GAALGCYLKSCQKSYHVPCALEIEECRWDMVNFLLLCPSHSSTRFPDERSKPR------------NQQDSSNWKPSPDGVNKWIFCPSALSAGERIILVK

Query:  FANISGAAVSKFWKPDVTHVIASTDANGACTRTYKVLMGILNGAWILNMDWVKACMKEKLPLSEEAYEIALDNYRCIDGPKSGRLRALYKASKLFTGLSF
        FA ISGA VSKFWKPDVTHVIAST  NGACTRTYKVLMGILNG WILNMDWVKACMKE+ PL+EE YEIALDNY CIDGPKSGRLR L  A KLFTGLSF
Subjt:  FANISGAAVSKFWKPDVTHVIASTDANGACTRTYKVLMGILNGAWILNMDWVKACMKEKLPLSEEAYEIALDNYRCIDGPKSGRLRALYKASKLFTGLSF

Query:  HFTDGFSSAYKEDLQDLVIAAGGRILEREERAAPSC-NDPAAALKVLVVYNLDFPEGCKVEDEVSILWQRLNDAEEIAAKIEAQVIGHTWLLESIASGNL
        +FT  F  AY+EDLQDLVI AGG ILE EE A PSC +D AAA KVLVVYNLD P GCKV +EVSILWQRLNDAE IAAK+ AQVIGHTWL+ESIA+GNL
Subjt:  HFTDGFSSAYKEDLQDLVIAAGGRILEREERAAPSC-NDPAAALKVLVVYNLDFPEGCKVEDEVSILWQRLNDAEEIAAKIEAQVIGHTWLLESIASGNL

Query:  QPFFSC
        QPF SC
Subjt:  QPFFSC

A0A6J1HW43 BRCA1-associated RING domain protein 1

4.4e-253

73.43

Show/hide

Query:  MRPASFMDKMVSIYKNLDATFSTNMPKLVSSVGIGVALEQSRFSQSVPFAASNCKEF-----------ENLYMEGRKHSCERLEDCRMPHESQVDQLSAE
        +RPA FMDKMVSIY++LDATF+TNM KLVS+V +G  +E+SRF QS P A  NCKEF           ENL +E RK S  R EDCRMP  SQ DQLSA 
Subjt:  MRPASFMDKMVSIYKNLDATFSTNMPKLVSSVGIGVALEQSRFSQSVPFAASNCKEF-----------ENLYMEGRKHSCERLEDCRMPHESQVDQLSAE

Query:  SRPPFGDGKVSDDSSDEYRRHGFKSASDRISIITSAGENNLELSKCTSSAVEEEGHLRSLKRQNLDYGPLKSGISGADHIHPPVSELGNSQTSNSEIEHK
        S PPFGDGKVSDDSSDEYR HG K+ASDR S+I +A +  L+LSKCTSS  EEEGHLR  KRQ LDYG LKSG S  D  HPP SELGNS+TSNSE+E K
Subjt:  SRPPFGDGKVSDDSSDEYRRHGFKSASDRISIITSAGENNLELSKCTSSAVEEEGHLRSLKRQNLDYGPLKSGISGADHIHPPVSELGNSQTSNSEIEHK

Query:  SRVNIACNMPIADADNAIVRNAKCAFCQSSQVTVDTGPILHYMNGTLVVEVEAANPNVIHVHKLCVDWTPQVYYQDNVIQNLKAEVARGSKLKCNKCGVK
        S+V IA N+P+ DA++AIVRNAKCAFCQSS+VT DTGP+LHY+NG+LVV VEA NPNVIH HKLCVDW PQ YYQ + + NLK+EVARGSKLKC+KCG+K
Subjt:  SRVNIACNMPIADADNAIVRNAKCAFCQSSQVTVDTGPILHYMNGTLVVEVEAANPNVIHVHKLCVDWTPQVYYQDNVIQNLKAEVARGSKLKCNKCGVK

Query:  GAALGCYLKSCQKSYHVPCALEIEECRWDMVNFLLLCPSHSSTRFPDERSKPR------------NQQDSSNWKPSPDGVNKWIFCPSALSAGERIILVK
        GAALGCY KSCQKSYHVPCALEIEECRWD  NFLLLCPSHSS RFPDERSK R            NQQDS+NW   PDGV KW FC SALSA ER IL+K
Subjt:  GAALGCYLKSCQKSYHVPCALEIEECRWDMVNFLLLCPSHSSTRFPDERSKPR------------NQQDSSNWKPSPDGVNKWIFCPSALSAGERIILVK

Query:  FANISGAAVSKFWKPDVTHVIASTDANGACTRTYKVLMGILNGAWILNMDWVKACMKEKLPLSEEAYEIALDNYRCIDGPKSGRLRALYKASKLFTGLSF
        FA ISGA VSKFWKPDVTHVIAST  NGACTRTYKVLMGILNG WILNMDWVKACMKE+ PL+EE YEIALDNY CIDGPKSGRLR L  A KLFTGLSF
Subjt:  FANISGAAVSKFWKPDVTHVIASTDANGACTRTYKVLMGILNGAWILNMDWVKACMKEKLPLSEEAYEIALDNYRCIDGPKSGRLRALYKASKLFTGLSF

Query:  HFTDGFSSAYKEDLQDLVIAAGGRILEREERAAPSC-NDPAAALKVLVVYNLDFPEGCKVEDEVSILWQRLNDAEEIAAKIEAQVIGHTWLLESIASGNL
        +FT  F  AY+EDLQDLVI AGG ILE EE A PSC +D A+A KVLVVYNLD P GCKV +EVSILWQRLNDAE IAAK+ AQVIGHTWL+ESIA+GNL
Subjt:  HFTDGFSSAYKEDLQDLVIAAGGRILEREERAAPSC-NDPAAALKVLVVYNLDFPEGCKVEDEVSILWQRLNDAEEIAAKIEAQVIGHTWLLESIASGNL

Query:  QPFFSC
        QPF SC
Subjt:  QPFFSC

SwissProt top hits

e value

%identity

Alignment

F4I443 BRCA1-associated RING domain protein 1

8.3e-108

Show/hide

Query:  CAFCQSSQVTVDTGPILHYMNGTLVVEVEAANPNVIHVHKLCVDWTPQVYYQDNVIQNLKAEVARGSKLKCNKCGVKGAALGCYLKSCQKSYHVPCALEI
        C FCQS++V+  TG +LHY  G  V   +    NVIHVH  C++W PQVYY+ + ++NLKAE+ARG K+KC KC +KGAALGC++KSC++SYHVPCA EI
Subjt:  CAFCQSSQVTVDTGPILHYMNGTLVVEVEAANPNVIHVHKLCVDWTPQVYYQDNVIQNLKAEVARGSKLKCNKCGVKGAALGCYLKSCQKSYHVPCALEI

Query:  EECRWDMVNFLLLCPSHSSTRFPDERSKPR----------NQQDSSNWKPSPDGVNKWIFCPSALSAGERIILVKFANISGAAVSKFWKPDVTHVIASTD
          CRWD  +FLLLCP+HSS +FP+E+S  R          N  +  + + +P    + + C SALS  ++ ++   A    A +S++W P VTHVIASTD
Subjt:  EECRWDMVNFLLLCPSHSSTRFPDERSKPR----------NQQDSSNWKPSPDGVNKWIFCPSALSAGERIILVKFANISGAAVSKFWKPDVTHVIASTD

Query:  ANGACTRTYKVLMGILNGAWILNMDWVKACMKEKLPLSEEAYEIALDNYRCIDGPKSGRLRALYKASKLFTGLSFHFTDGFSSAYKEDLQDLVIAAGGRI
          GACTRT KVLMGILNG WI+N  W+KA +K   P+ EE +EI +D   C DGPK+ RLRA     KLF GL F+F   F   YKEDLQ+LV  AGG I
Subjt:  ANGACTRTYKVLMGILNGAWILNMDWVKACMKEKLPLSEEAYEIALDNYRCIDGPKSGRLRALYKASKLFTGLSFHFTDGFSSAYKEDLQDLVIAAGGRI

Query:  LEREER--AAPSCNDPAAALKVLVVYNLDFPEGCKVEDEVSILWQRLNDAEEIAAKIEAQVIGHTWLLESIASGNLQP
        L  E+   A  S N        +VVYN+D P GC + +EV+I+WQR NDAE +A++  ++++GHTW+LESIA   L P
Subjt:  LEREER--AAPSCNDPAAALKVLVVYNLDFPEGCKVEDEVSILWQRLNDAEEIAAKIEAQVIGHTWLLESIASGNLQP

O70445 BRCA1-associated RING domain protein 1

3.3e-16

34.46

Show/hide

Query:  IFCPSALSAGERIILVKFANISGAAVSKFWKPDVTHVIASTDANGACTRTYKVLMGILNGAWILNMDWVKACMKEKLPLSEEAYEIALDNYRCIDGPKSG
        +F  S LS+ ++ +L K   +  A     +   VTHVI   +       T K ++GIL+G WIL  DWVKAC+  K+   EE YE+         GP+  
Subjt:  IFCPSALSAGERIILVKFANISGAAVSKFWKPDVTHVIASTDANGACTRTYKVLMGILNGAWILNMDWVKACMKEKLPLSEEAYEIALDNYRCIDGPKSG

Query:  RLRALYKASKLFTGLSFHFTDGFSSAYKEDLQDLVIAAGGRILEREER
        RL       KLF G  F     F    ++DL  L+ AAGG++L R+ +
Subjt:  RLRALYKASKLFTGLSFHFTDGFSSAYKEDLQDLVIAAGGRILEREER

Q8RXD4 Protein BREAST CANCER SUSCEPTIBILITY 1 homolog

7.6e-77

35.12

Show/hide

Query:  PHESQVDQLSAESRPPFGD-GKVSDDSSDEYRRHGFKSASDRISIITSAGENNLELSKCTSSAVEEEGHLRSLKRQNLDYGPLKSGISGADHIHPPVSEL
        P ++  ++ S   +P     G+ S+ SS        K  S +    TS  +  L+    +S A +  G+        +    L  G    D  +   S +
Subjt:  PHESQVDQLSAESRPPFGD-GKVSDDSSDEYRRHGFKSASDRISIITSAGENNLELSKCTSSAVEEEGHLRSLKRQNLDYGPLKSGISGADHIHPPVSEL

Query:  GNSQTSNSEIEHKSRVNIAC---NMPIADADNAIVRNAKCAFCQSSQVTVDTGPILHYMNGTLVVEVEAANPNVIHVHKLCVDWTPQVYYQDNVIQNLKA
        G    +   IE  S +N +    +  +   + ++ +   CAFCQ S+ T  +G + HY  G  V         VIHVHK C +W P VY+ D  I NL  
Subjt:  GNSQTSNSEIEHKSRVNIAC---NMPIADADNAIVRNAKCAFCQSSQVTVDTGPILHYMNGTLVVEVEAANPNVIHVHKLCVDWTPQVYYQDNVIQNLKA

Query:  EVARGSKLKCNKCGVKGAALGCYLKSCQKSYHVPCALEIEECRWDMVNFLLLCPSHSSTRFPDERSKPRNQQDSSNWK----PSPDGVN-----------
        E+ R  ++ C+ CG+KGAALGCY KSC+ S+HV CA  I ECRWD V F++LCP  +S + P E +  ++++     K      P  V+           
Subjt:  EVARGSKLKCNKCGVKGAALGCYLKSCQKSYHVPCALEIEECRWDMVNFLLLCPSHSSTRFPDERSKPRNQQDSSNWK----PSPDGVN-----------

Query:  -------KWIFCPSALSAGERIILVKFANISGAAVSKFWKPDVTHVIASTDANGACTRTYKVLMGILNGAWILNMDWVKACMKEKLPLSEEAYEIALDNY
               K +   S L+  E+ ++ +FA +SG  +SK W   VTHVIAS + NGAC RT K +M IL G WIL +DW+KACMK    +SEE YEI +D +
Subjt:  -------KWIFCPSALSAGERIILVKFANISGAAVSKFWKPDVTHVIASTDANGACTRTYKVLMGILNGAWILNMDWVKACMKEKLPLSEEAYEIALDNY

Query:  RCIDGPKSGRLRALYKASKLFTGLSFHFTDGFSSAYKEDLQDLVIAAGGRILEREERAAPSCNDPAAALKVLVVYNLDFPEGCKVEDEVSILWQRLNDAE
           +GP  GR RAL K  KLFTGL F+    F  AYK  LQDL++AAGG IL R     P  +D   A   +VV++++         +   L QR +DAE
Subjt:  RCIDGPKSGRLRALYKASKLFTGLSFHFTDGFSSAYKEDLQDLVIAAGGRILEREERAAPSCNDPAAALKVLVVYNLDFPEGCKVEDEVSILWQRLNDAE

Query:  EIAAKIEAQVIGHTWLLESIA
         +A    A+    +W+L+SIA
Subjt:  EIAAKIEAQVIGHTWLLESIA

Q99728 BRCA1-associated RING domain protein 1

3.3e-16

37.5

Show/hide

Query:  SALSAGERIILVKFANISGAAVSKFWKPDVTHVIASTDANGACTRTYKVLMGILNGAWILNMDWVKACMKEKLPLSEEAYEIALDNYRCIDGPKSGRLRA
        S LS+ ++ +L + A I  A     +   VTHV+   D   A   T K ++GILNG WIL  +WVKAC++ K+   EE YEI        +GP+  RL  
Subjt:  SALSAGERIILVKFANISGAAVSKFWKPDVTHVIASTDANGACTRTYKVLMGILNGAWILNMDWVKACMKEKLPLSEEAYEIALDNYRCIDGPKSGRLRA

Query:  LYKASKLFTGLSFHFTDGFSSAYKEDLQDLVIAAGGRILEREER
             KLF G  F+    F    K++L  LV A GG+IL R+ +
Subjt:  LYKASKLFTGLSFHFTDGFSSAYKEDLQDLVIAAGGRILEREER

Q9QZH2 BRCA1-associated RING domain protein 1

4.4e-16

36.81

Show/hide

Query:  SALSAGERIILVKFANISGAAVSKFWKPDVTHVIASTDANGACTRTYKVLMGILNGAWILNMDWVKACMKEKLPLSEEAYEIALDNYRCIDGPKSGRLRA
        S LS+ ++ +L K   +  A     +   VTHVI   +       T K ++GILNG W+L  DWVKAC+  +    EE YE+         GP+  RL  
Subjt:  SALSAGERIILVKFANISGAAVSKFWKPDVTHVIASTDANGACTRTYKVLMGILNGAWILNMDWVKACMKEKLPLSEEAYEIALDNYRCIDGPKSGRLRA

Query:  LYKASKLFTGLSFHFTDGFSSAYKEDLQDLVIAAGGRILEREER
             KLF G  F     F    KEDL  L+ AAGGRIL R+ +
Subjt:  LYKASKLFTGLSFHFTDGFSSAYKEDLQDLVIAAGGRILEREER

Arabidopsis top hits

e value

%identity

Alignment

AT1G04020.1 breast cancer associated RING 1

5.9e-109

Show/hide

Query:  CAFCQSSQVTVDTGPILHYMNGTLVVEVEAANPNVIHVHKLCVDWTPQVYYQDNVIQNLKAEVARGSKLKCNKCGVKGAALGCYLKSCQKSYHVPCALEI
        C FCQS++V+  TG +LHY  G  V   +    NVIHVH  C++W PQVYY+ + ++NLKAE+ARG K+KC KC +KGAALGC++KSC++SYHVPCA EI
Subjt:  CAFCQSSQVTVDTGPILHYMNGTLVVEVEAANPNVIHVHKLCVDWTPQVYYQDNVIQNLKAEVARGSKLKCNKCGVKGAALGCYLKSCQKSYHVPCALEI

Query:  EECRWDMVNFLLLCPSHSSTRFPDERSKPR----------NQQDSSNWKPSPDGVNKWIFCPSALSAGERIILVKFANISGAAVSKFWKPDVTHVIASTD
          CRWD  +FLLLCP+HSS +FP+E+S  R          N  +  + + +P    + + C SALS  ++ ++   A    A +S++W P VTHVIASTD
Subjt:  EECRWDMVNFLLLCPSHSSTRFPDERSKPR----------NQQDSSNWKPSPDGVNKWIFCPSALSAGERIILVKFANISGAAVSKFWKPDVTHVIASTD

Query:  ANGACTRTYKVLMGILNGAWILNMDWVKACMKEKLPLSEEAYEIALDNYRCIDGPKSGRLRALYKASKLFTGLSFHFTDGFSSAYKEDLQDLVIAAGGRI
          GACTRT KVLMGILNG WI+N  W+KA +K   P+ EE +EI +D   C DGPK+ RLRA     KLF GL F+F   F   YKEDLQ+LV  AGG I
Subjt:  ANGACTRTYKVLMGILNGAWILNMDWVKACMKEKLPLSEEAYEIALDNYRCIDGPKSGRLRALYKASKLFTGLSFHFTDGFSSAYKEDLQDLVIAAGGRI

Query:  LEREER--AAPSCNDPAAALKVLVVYNLDFPEGCKVEDEVSILWQRLNDAEEIAAKIEAQVIGHTWLLESIASGNLQP
        L  E+   A  S N        +VVYN+D P GC + +EV+I+WQR NDAE +A++  ++++GHTW+LESIA   L P
Subjt:  LEREER--AAPSCNDPAAALKVLVVYNLDFPEGCKVEDEVSILWQRLNDAEEIAAKIEAQVIGHTWLLESIASGNLQP

AT1G04020.2 breast cancer associated RING 1

5.9e-109

Show/hide

Query:  CAFCQSSQVTVDTGPILHYMNGTLVVEVEAANPNVIHVHKLCVDWTPQVYYQDNVIQNLKAEVARGSKLKCNKCGVKGAALGCYLKSCQKSYHVPCALEI
        C FCQS++V+  TG +LHY  G  V   +    NVIHVH  C++W PQVYY+ + ++NLKAE+ARG K+KC KC +KGAALGC++KSC++SYHVPCA EI
Subjt:  CAFCQSSQVTVDTGPILHYMNGTLVVEVEAANPNVIHVHKLCVDWTPQVYYQDNVIQNLKAEVARGSKLKCNKCGVKGAALGCYLKSCQKSYHVPCALEI

Query:  EECRWDMVNFLLLCPSHSSTRFPDERSKPR----------NQQDSSNWKPSPDGVNKWIFCPSALSAGERIILVKFANISGAAVSKFWKPDVTHVIASTD
          CRWD  +FLLLCP+HSS +FP+E+S  R          N  +  + + +P    + + C SALS  ++ ++   A    A +S++W P VTHVIASTD
Subjt:  EECRWDMVNFLLLCPSHSSTRFPDERSKPR----------NQQDSSNWKPSPDGVNKWIFCPSALSAGERIILVKFANISGAAVSKFWKPDVTHVIASTD

Query:  ANGACTRTYKVLMGILNGAWILNMDWVKACMKEKLPLSEEAYEIALDNYRCIDGPKSGRLRALYKASKLFTGLSFHFTDGFSSAYKEDLQDLVIAAGGRI
          GACTRT KVLMGILNG WI+N  W+KA +K   P+ EE +EI +D   C DGPK+ RLRA     KLF GL F+F   F   YKEDLQ+LV  AGG I
Subjt:  ANGACTRTYKVLMGILNGAWILNMDWVKACMKEKLPLSEEAYEIALDNYRCIDGPKSGRLRALYKASKLFTGLSFHFTDGFSSAYKEDLQDLVIAAGGRI

Query:  LEREER--AAPSCNDPAAALKVLVVYNLDFPEGCKVEDEVSILWQRLNDAEEIAAKIEAQVIGHTWLLESIASGNLQP
        L  E+   A  S N        +VVYN+D P GC + +EV+I+WQR NDAE +A++  ++++GHTW+LESIA   L P
Subjt:  LEREER--AAPSCNDPAAALKVLVVYNLDFPEGCKVEDEVSILWQRLNDAEEIAAKIEAQVIGHTWLLESIASGNLQP

AT3G15120.1 P-loop containing nucleoside triphosphate hydrolases superfamily protein

1.4e-06

26.98

Show/hide

Query:  VHKLCVDWTPQVYYQD-NVIQNLKAEVARGSKLKCNKCGVKGAALGCYLKSCQKSYHVPCALEIEECRWDMVNFLLLCPSH-------------SSTRFP
        VH+ C  W+P+VY+     ++N++A + RG  LKC +C   GA  GC           PCA     C +D   FL+ C  H               T+  
Subjt:  VHKLCVDWTPQVYYQD-NVIQNLKAEVARGSKLKCNKCGVKGAALGCYLKSCQKSYHVPCALEIEECRWDMVNFLLLCPSH-------------SSTRFP

Query:  DERSKPRNQQDSSN-WKPSPDGVNKW
         +R +   ++ S++ W+   +   KW
Subjt:  DERSKPRNQQDSSN-WKPSPDGVNKW

AT4G21070.1 breast cancer susceptibility1

5.4e-78

35.12

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Query:  PHESQVDQLSAESRPPFGD-GKVSDDSSDEYRRHGFKSASDRISIITSAGENNLELSKCTSSAVEEEGHLRSLKRQNLDYGPLKSGISGADHIHPPVSEL
        P ++  ++ S   +P     G+ S+ SS        K  S +    TS  +  L+    +S A +  G+        +    L  G    D  +   S +
Subjt:  PHESQVDQLSAESRPPFGD-GKVSDDSSDEYRRHGFKSASDRISIITSAGENNLELSKCTSSAVEEEGHLRSLKRQNLDYGPLKSGISGADHIHPPVSEL

Query:  GNSQTSNSEIEHKSRVNIAC---NMPIADADNAIVRNAKCAFCQSSQVTVDTGPILHYMNGTLVVEVEAANPNVIHVHKLCVDWTPQVYYQDNVIQNLKA
        G    +   IE  S +N +    +  +   + ++ +   CAFCQ S+ T  +G + HY  G  V         VIHVHK C +W P VY+ D  I NL  
Subjt:  GNSQTSNSEIEHKSRVNIAC---NMPIADADNAIVRNAKCAFCQSSQVTVDTGPILHYMNGTLVVEVEAANPNVIHVHKLCVDWTPQVYYQDNVIQNLKA

Query:  EVARGSKLKCNKCGVKGAALGCYLKSCQKSYHVPCALEIEECRWDMVNFLLLCPSHSSTRFPDERSKPRNQQDSSNWK----PSPDGVN-----------
        E+ R  ++ C+ CG+KGAALGCY KSC+ S+HV CA  I ECRWD V F++LCP  +S + P E +  ++++     K      P  V+           
Subjt:  EVARGSKLKCNKCGVKGAALGCYLKSCQKSYHVPCALEIEECRWDMVNFLLLCPSHSSTRFPDERSKPRNQQDSSNWK----PSPDGVN-----------

Query:  -------KWIFCPSALSAGERIILVKFANISGAAVSKFWKPDVTHVIASTDANGACTRTYKVLMGILNGAWILNMDWVKACMKEKLPLSEEAYEIALDNY
               K +   S L+  E+ ++ +FA +SG  +SK W   VTHVIAS + NGAC RT K +M IL G WIL +DW+KACMK    +SEE YEI +D +
Subjt:  -------KWIFCPSALSAGERIILVKFANISGAAVSKFWKPDVTHVIASTDANGACTRTYKVLMGILNGAWILNMDWVKACMKEKLPLSEEAYEIALDNY

Query:  RCIDGPKSGRLRALYKASKLFTGLSFHFTDGFSSAYKEDLQDLVIAAGGRILEREERAAPSCNDPAAALKVLVVYNLDFPEGCKVEDEVSILWQRLNDAE
           +GP  GR RAL K  KLFTGL F+    F  AYK  LQDL++AAGG IL R     P  +D   A   +VV++++         +   L QR +DAE
Subjt:  RCIDGPKSGRLRALYKASKLFTGLSFHFTDGFSSAYKEDLQDLVIAAGGRILEREERAAPSCNDPAAALKVLVVYNLDFPEGCKVEDEVSILWQRLNDAE

Query:  EIAAKIEAQVIGHTWLLESIA
         +A    A+    +W+L+SIA
Subjt:  EIAAKIEAQVIGHTWLLESIA

Sequences

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CDS sequence

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ATGAGGCCGGCTTCTTTCATGGACAAGATGGTATCAATCTACAAGAATCTGGATGCTACATTTTCCACAAATATGCCTAAACTAGTCTCATCCGTAGGCATCGGGGTAGC
TTTGGAGCAATCGCGTTTTAGTCAATCTGTCCCTTTTGCTGCCAGCAACTGCAAGGAGTTTGAGAATCTTTATATGGAGGGTCGTAAGCATAGTTGTGAGAGGCTTGAAG
ATTGCAGAATGCCACATGAGAGTCAGGTAGACCAGTTATCAGCCGAAAGCCGGCCTCCATTTGGTGATGGCAAGGTGTCAGATGACAGTAGTGATGAGTACCGTCGTCAT
GGATTTAAAAGTGCTTCGGACAGAATATCTATTATAACAAGCGCTGGTGAAAATAACCTGGAATTATCAAAGTGTACGAGTTCTGCTGTTGAAGAGGAAGGTCACTTGAG
GAGCCTCAAGAGACAAAATTTGGATTATGGTCCGTTGAAGTCAGGCATAAGTGGTGCTGATCATATCCATCCTCCAGTTTCAGAGTTAGGAAATTCACAGACTTCAAATT
CTGAAATTGAACACAAATCCCGAGTTAATATTGCTTGCAATATGCCTATTGCTGATGCAGACAATGCCATTGTGAGAAATGCCAAATGTGCATTTTGCCAGTCTTCTCAA
GTTACAGTGGATACTGGACCTATCCTGCATTATATGAATGGTACTTTGGTCGTCGAAGTTGAAGCAGCGAATCCAAATGTCATACATGTTCACAAACTTTGTGTTGATTG
GACACCACAAGTATACTATCAAGATAATGTTATTCAAAATTTAAAGGCTGAAGTAGCAAGGGGTTCAAAGCTTAAGTGTAATAAATGTGGGGTAAAAGGAGCAGCCCTGG
GTTGTTATTTGAAGTCTTGCCAGAAAAGCTATCACGTTCCTTGTGCACTTGAAATAGAGGAGTGCCGTTGGGACATGGTTAATTTTCTTCTTCTGTGTCCCTCACATTCG
TCAACAAGATTTCCTGATGAAAGGTCTAAGCCTAGGAACCAGCAAGATTCAAGCAATTGGAAACCTTCACCAGATGGGGTAAATAAATGGATATTTTGTCCATCAGCTCT
GTCTGCTGGAGAGAGGATTATATTGGTCAAGTTTGCAAATATATCTGGTGCCGCAGTGTCCAAATTTTGGAAGCCAGATGTTACTCATGTTATTGCCTCCACCGATGCGA
ATGGTGCTTGTACTCGGACCTATAAAGTACTGATGGGCATATTGAATGGAGCATGGATTCTGAATATGGATTGGGTAAAAGCTTGCATGAAAGAAAAGCTTCCTTTGAGT
GAGGAAGCTTATGAAATTGCTCTTGACAACTACCGGTGCATTGATGGTCCCAAATCTGGCAGGCTGAGGGCTTTATACAAAGCATCCAAGCTCTTCACCGGCTTAAGCTT
CCATTTTACCGATGGTTTTTCGTCGGCTTACAAGGAGGATCTTCAAGATTTGGTTATAGCAGCTGGAGGTAGAATTTTAGAGAGAGAAGAACGAGCAGCACCGAGTTGTA
ATGACCCGGCTGCTGCACTAAAGGTGCTGGTTGTTTATAATCTCGATTTTCCGGAAGGGTGCAAAGTGGAGGATGAGGTTTCTATTCTGTGGCAAAGGTTGAATGATGCA
GAGGAAATAGCTGCTAAAATTGAAGCTCAAGTAATTGGTCATACATGGCTTCTGGAATCCATTGCATCAGGTAACTTGCAACCTTTTTTCAGCTGCTAA

mRNA sequence

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CGTGCAGGCAGCAGCCGCCGAACTTCAAACGTCACCGTTCCGCCACCCAAATCCACCAGCGGCGGCTCTCAAAATTGAATCCAAACCGTCCACGTGTCAAGAATCCACAT
CCCTCTCCTTCTCATAAATTTCTCTGCACTTCCATTGATTCTCCAATGTAATCATCAACCATGGAGGAATTTTCAAGCAATGGCGGCCGTGTTTGTGGCGATAATTCCAG
TTTAGGTTTTTGAATCCTTCGGTTCTTAAGTTCCAGAGAATGGAGGTGGAGCTCAAGTGCCCTCTCTGCTTGAACTTCTTCGATCAACCTCTATTGCTTCCTTGCAATCA
CCTCTTTTGCAAACATGAGGCCGGCTTCTTTCATGGACAAGATGGTATCAATCTACAAGAATCTGGATGCTACATTTTCCACAAATATGCCTAAACTAGTCTCATCCGTA
GGCATCGGGGTAGCTTTGGAGCAATCGCGTTTTAGTCAATCTGTCCCTTTTGCTGCCAGCAACTGCAAGGAGTTTGAGAATCTTTATATGGAGGGTCGTAAGCATAGTTG
TGAGAGGCTTGAAGATTGCAGAATGCCACATGAGAGTCAGGTAGACCAGTTATCAGCCGAAAGCCGGCCTCCATTTGGTGATGGCAAGGTGTCAGATGACAGTAGTGATG
AGTACCGTCGTCATGGATTTAAAAGTGCTTCGGACAGAATATCTATTATAACAAGCGCTGGTGAAAATAACCTGGAATTATCAAAGTGTACGAGTTCTGCTGTTGAAGAG
GAAGGTCACTTGAGGAGCCTCAAGAGACAAAATTTGGATTATGGTCCGTTGAAGTCAGGCATAAGTGGTGCTGATCATATCCATCCTCCAGTTTCAGAGTTAGGAAATTC
ACAGACTTCAAATTCTGAAATTGAACACAAATCCCGAGTTAATATTGCTTGCAATATGCCTATTGCTGATGCAGACAATGCCATTGTGAGAAATGCCAAATGTGCATTTT
GCCAGTCTTCTCAAGTTACAGTGGATACTGGACCTATCCTGCATTATATGAATGGTACTTTGGTCGTCGAAGTTGAAGCAGCGAATCCAAATGTCATACATGTTCACAAA
CTTTGTGTTGATTGGACACCACAAGTATACTATCAAGATAATGTTATTCAAAATTTAAAGGCTGAAGTAGCAAGGGGTTCAAAGCTTAAGTGTAATAAATGTGGGGTAAA
AGGAGCAGCCCTGGGTTGTTATTTGAAGTCTTGCCAGAAAAGCTATCACGTTCCTTGTGCACTTGAAATAGAGGAGTGCCGTTGGGACATGGTTAATTTTCTTCTTCTGT
GTCCCTCACATTCGTCAACAAGATTTCCTGATGAAAGGTCTAAGCCTAGGAACCAGCAAGATTCAAGCAATTGGAAACCTTCACCAGATGGGGTAAATAAATGGATATTT
TGTCCATCAGCTCTGTCTGCTGGAGAGAGGATTATATTGGTCAAGTTTGCAAATATATCTGGTGCCGCAGTGTCCAAATTTTGGAAGCCAGATGTTACTCATGTTATTGC
CTCCACCGATGCGAATGGTGCTTGTACTCGGACCTATAAAGTACTGATGGGCATATTGAATGGAGCATGGATTCTGAATATGGATTGGGTAAAAGCTTGCATGAAAGAAA
AGCTTCCTTTGAGTGAGGAAGCTTATGAAATTGCTCTTGACAACTACCGGTGCATTGATGGTCCCAAATCTGGCAGGCTGAGGGCTTTATACAAAGCATCCAAGCTCTTC
ACCGGCTTAAGCTTCCATTTTACCGATGGTTTTTCGTCGGCTTACAAGGAGGATCTTCAAGATTTGGTTATAGCAGCTGGAGGTAGAATTTTAGAGAGAGAAGAACGAGC
AGCACCGAGTTGTAATGACCCGGCTGCTGCACTAAAGGTGCTGGTTGTTTATAATCTCGATTTTCCGGAAGGGTGCAAAGTGGAGGATGAGGTTTCTATTCTGTGGCAAA
GGTTGAATGATGCAGAGGAAATAGCTGCTAAAATTGAAGCTCAAGTAATTGGTCATACATGGCTTCTGGAATCCATTGCATCAGGTAACTTGCAACCTTTTTTCAGCTGC
TAAATGGATGGTGCCTGTCTTTTTGTGCTGATTCAATGCTTAGTGATGCATTTAAATAATTGACCTGATCATATACCTGTAGTTTTGGCCCTTGTACAAATTGAAACTAA
TCTGAATAGTTGGTTTACATTTGTTAGGATATTTTGTAGTACTGTG

Protein sequence

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MRPASFMDKMVSIYKNLDATFSTNMPKLVSSVGIGVALEQSRFSQSVPFAASNCKEFENLYMEGRKHSCERLEDCRMPHESQVDQLSAESRPPFGDGKVSDDSSDEYRRH
GFKSASDRISIITSAGENNLELSKCTSSAVEEEGHLRSLKRQNLDYGPLKSGISGADHIHPPVSELGNSQTSNSEIEHKSRVNIACNMPIADADNAIVRNAKCAFCQSSQ
VTVDTGPILHYMNGTLVVEVEAANPNVIHVHKLCVDWTPQVYYQDNVIQNLKAEVARGSKLKCNKCGVKGAALGCYLKSCQKSYHVPCALEIEECRWDMVNFLLLCPSHS
STRFPDERSKPRNQQDSSNWKPSPDGVNKWIFCPSALSAGERIILVKFANISGAAVSKFWKPDVTHVIASTDANGACTRTYKVLMGILNGAWILNMDWVKACMKEKLPLS
EEAYEIALDNYRCIDGPKSGRLRALYKASKLFTGLSFHFTDGFSSAYKEDLQDLVIAAGGRILEREERAAPSCNDPAAALKVLVVYNLDFPEGCKVEDEVSILWQRLNDA
EEIAAKIEAQVIGHTWLLESIASGNLQPFFSC

Sed0023051 (gene) of Chayote v1 genome