CuGenDBv2

Gene ID	Sed0024196
Organism	Sechium edule (Chayote v1)
Description	DNA topoisomerase I
Genome location	LG08:40214815..40222061
RNA-Seq Expression	Sed0024196
Synteny	Sed0024196
Gene Ontology terms	GO:0006260 - DNA replication (biological process) GO:0006265 - DNA topological change (biological process) GO:0006338 - chromatin remodeling (biological process) GO:0007059 - chromosome segregation (biological process) GO:0005694 - chromosome (cellular component) GO:0005730 - nucleolus (cellular component) GO:0003677 - DNA binding (molecular function) GO:0003917 - DNA topoisomerase type I activity (molecular function)
InterPro domains	IPR011010 - DNA breaking-rejoining enzyme, catalytic core IPR036202 - DNA topoisomerase I, DNA binding, eukaryotic-type, N-terminal domain superfamily IPR025834 - Topoisomerase I C-terminal domain IPR018521 - DNA topoisomerase I, active site IPR014727 - DNA topoisomerase I, catalytic core, alpha/beta subdomain IPR014711 - DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type IPR013500 - DNA topoisomerase I, catalytic core, eukaryotic-type IPR013499 - DNA topoisomerase I, eukaryotic-type IPR013034 - DNA topoisomerase I, DNA binding, N-terminal domain 1 IPR013030 - DNA topoisomerase I, DNA binding, N-terminal domain 2 IPR008336 - DNA topoisomerase I, DNA binding, eukaryotic-type IPR001631 - DNA topoisomerase I

Homology

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GenBank top hits

e value

%identity

Alignment

KAG7015549.1 DNA topoisomerase 1 beta [Cucurbita argyrosperma subsp. argyrosperma]

0.0e+00

89.08

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Query:  MAVQTFGKAPMFDDDDEDDVPIVFKRSSASRQNQLDSEAK----QRLNKLTGKQGSDVSSPNGQSSNAQKRTTSLPKASPLKSEIGRQKAPNSSIQAPLA
        MAV+TFGKAPMFDDDDED++PIVFKRSSASRQNQL+SE K    QRLN+L+G+ GSD  S NGQSSNAQKR TSLPK SP++ EIG QKA  SSIQ PL 
Subjt:  MAVQTFGKAPMFDDDDEDDVPIVFKRSSASRQNQLDSEAK----QRLNKLTGKQGSDVSSPNGQSSNAQKRTTSLPKASPLKSEIGRQKAPNSSIQAPLA

Query:  KS-----QLSDSMDSRPKSLANAAVKKEND-IHPAWESSDSEDDKPLSCRLKGNSNLPSKQLTPTVPKNKVKKSSGDSDDEIPLSSKFQMKSASGASGGK
        KS     ++SDSMDSRPK LANAA+K+END IHP  E+SDSEDDKPLS RLKGNSN PSK   PTV KNK+KKSS DSDDE+PLSSKFQMKSASG  GGK
Subjt:  KS-----QLSDSMDSRPKSLANAAVKKEND-IHPAWESSDSEDDKPLSCRLKGNSNLPSKQLTPTVPKNKVKKSSGDSDDEIPLSSKFQMKSASGASGGK

Query:  QHGFDEKNPLVSKVHQNGSTSRDKLQKPAIVYGKRPLPNADSHSSPQLSIKKPKLSDSSTPSSVKIVSLKEKQEVDDDDDDIPISQRMKKMSASVNKQSS
        QHGFDEK PL SKVHQNGSTSRDKLQKPA+V  KRPLPNADSHSS Q+S+KKPKLSDSSTP S   VSLK KQEV DDDD IPISQRM KMSA+VNK S 
Subjt:  QHGFDEKNPLVSKVHQNGSTSRDKLQKPAIVYGKRPLPNADSHSSPQLSIKKPKLSDSSTPSSVKIVSLKEKQEVDDDDDDIPISQRMKKMSASVNKQSS

Query:  SKQTVSKVASSSIKKTFKKFEKPVKKSKYGKSTKLLPSAGDGQKKWTTLVHNGVIFPPPYQTHRVKMLYKGKPVGLTPEQEEVATMFAVMKDTDYMLKPK
        SK+TVSKVASSSIKKT KK +KPVKKSKY KSTKLLPS+GDGQKKWTTLVHNGVIFPPPYQTH VK+L+KGKPV LTPEQEEVATMFAVMKDTDYM KPK
Subjt:  SKQTVSKVASSSIKKTFKKFEKPVKKSKYGKSTKLLPSAGDGQKKWTTLVHNGVIFPPPYQTHRVKMLYKGKPVGLTPEQEEVATMFAVMKDTDYMLKPK

Query:  FKENFWNDWRKILGKNHAIQNLDDCDFTPIYDWYQIEKEKKKQMTSEEKKALKEEKLKQEEKYMWAILDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKK
        FKENFWNDWRK+LGKNH IQNLDDCDFTPIYDWYQ EKEKKKQMT+EEKKALKEEKLKQEEKYMWAILDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKK
Subjt:  FKENFWNDWRKILGKNHAIQNLDDCDFTPIYDWYQIEKEKKKQMTSEEKKALKEEKLKQEEKYMWAILDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKK

Query:  RIRPSDITINIGKDAPIPECPIPGERWKEVRHDNTVTWLAFWNDPINPKEFKYVFLAASSSLKGQSDKEKYEKARMLKDYIKNIRNAYTKDFTSKDPTRR
        RIRPSDITINIGKDAPIPECPIPG+RWKEVRHDNTVTWLAFWNDPINPKEFKYVFLAASSSLKGQSDKEKYEKARMLKDYIKNIRN+YTKDFTSKDPTRR
Subjt:  RIRPSDITINIGKDAPIPECPIPGERWKEVRHDNTVTWLAFWNDPINPKEFKYVFLAASSSLKGQSDKEKYEKARMLKDYIKNIRNAYTKDFTSKDPTRR

Query:  QIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVKAVPPNLLEFNFLGKDSIKYENTVEVELPVFKAITQFQSGKSGSDDLFDKLDTSKLNAHLKD
        QIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVKAVPPNLLEFNFLGKDSIKYENTVEVELPVFKAITQFQSGKSGSDDLFDKLDTSKLNAHLKD
Subjt:  QIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVKAVPPNLLEFNFLGKDSIKYENTVEVELPVFKAITQFQSGKSGSDDLFDKLDTSKLNAHLKD

Query:  LMPGLTAKVFRTYNASITLDDMLNRGTKEGEVAEKIATYQHANKEVAIICNHQRTVSKSHGAQMSRLNEKISELRDILKELKIDLDRAKKGKPPLKDADG
        LMPGLTAKVFRTYNASITLDDMLNRGTK+GEV+EKI TYQHANKEVAIICNHQRTVSKSHGAQM+RLNEKISELRDILKELKIDLDRAKKGKPPLK +DG
Subjt:  LMPGLTAKVFRTYNASITLDDMLNRGTKEGEVAEKIATYQHANKEVAIICNHQRTVSKSHGAQMSRLNEKISELRDILKELKIDLDRAKKGKPPLKDADG

Query:  KQKRNLAPEALEKKISQTNVKIEKIERDMQTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFAWAMDVDPDFRF
        KQKRNL PEALEKKISQTN KIEKIERDM+TKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFAWAMDVDP+FRF
Subjt:  KQKRNLAPEALEKKISQTNVKIEKIERDMQTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFAWAMDVDPDFRF

XP_008449103.1 PREDICTED: DNA topoisomerase 1-like [Cucumis melo]

0.0e+00

88.64

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Query:  MAVQTFGKAPMFDDDDEDDVPIVFKRSSASRQNQLDSEAK----QRLNKLTGKQGSDVSSPNGQSSNAQKRTTSLPKASPLKSEIGRQKAPNSS-IQAPL
        MAV+TFGKAPMFDDDDED++PIVFKRSSASRQNQLDSE K    QRLNKL G+QGSD+ S NGQSSN QKR TSLPK SP++SEIG QKAP SS IQ PL
Subjt:  MAVQTFGKAPMFDDDDEDDVPIVFKRSSASRQNQLDSEAK----QRLNKLTGKQGSDVSSPNGQSSNAQKRTTSLPKASPLKSEIGRQKAPNSS-IQAPL

Query:  AKS-----QLSDSMDSRPKSLANAAVKKEN-DIHPAWESSDSEDDKPLSCRLKGNSNLPSKQLTPTVPKNKVKKSSGDSDDEIPLSSKFQMKSASGASGG
         KS     + SDSMDSRPK+L NAAVK+EN  I+P+ E+SDSEDDKPLS RLKGNSN P+K L  T+PKNKVKKSSGDSDDE+PLSSKFQMK ASG  G 
Subjt:  AKS-----QLSDSMDSRPKSLANAAVKKEN-DIHPAWESSDSEDDKPLSCRLKGNSNLPSKQLTPTVPKNKVKKSSGDSDDEIPLSSKFQMKSASGASGG

Query:  KQHGFDEKNPLVSKVHQNGSTSRDKLQKPAIVYGKRPLPNADSHSSPQLSIKKPKLSDSSTPSSVKIVSLKEKQEVDDDDDDIPISQRMKKMSASVNKQS
        KQ GFDEK PLV KVHQNGSTSRDKLQKPA++  KRPLPN DSHS  Q S KKPKLSDSS+P S K+VSLK KQEVDDDDDDIPISQR+KK  A+VNK S
Subjt:  KQHGFDEKNPLVSKVHQNGSTSRDKLQKPAIVYGKRPLPNADSHSSPQLSIKKPKLSDSSTPSSVKIVSLKEKQEVDDDDDDIPISQRMKKMSASVNKQS

Query:  SSKQTVSKVASSSIKKTFKKFEKPVKKSKYGKSTKLLPSAGDGQKKWTTLVHNGVIFPPPYQTHRVKMLYKGKPVGLTPEQEEVATMFAVMKDTDYMLKP
        SSK TVSKV SSSIKKTFKK +KPVKKSKY KSTKLLPSAGDGQKKWTTLVHNGVIFPPPYQTH VKMLYKGKPV LTP+QEEVATMFAVMKDTDYMLKP
Subjt:  SSKQTVSKVASSSIKKTFKKFEKPVKKSKYGKSTKLLPSAGDGQKKWTTLVHNGVIFPPPYQTHRVKMLYKGKPVGLTPEQEEVATMFAVMKDTDYMLKP

Query:  KFKENFWNDWRKILGKNHAIQNLDDCDFTPIYDWYQIEKEKKKQMTSEEKKALKEEKLKQEEKYMWAILDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLK
        KFKENFWNDWRK+LGKNH IQNLDDCDFTPIYDWYQ+EKEKKKQMT+EEKKALKEEKLKQEEKYMWAILDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLK
Subjt:  KFKENFWNDWRKILGKNHAIQNLDDCDFTPIYDWYQIEKEKKKQMTSEEKKALKEEKLKQEEKYMWAILDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLK

Query:  KRIRPSDITINIGKDAPIPECPIPGERWKEVRHDNTVTWLAFWNDPINPKEFKYVFLAASSSLKGQSDKEKYEKARMLKDYIKNIRNAYTKDFTSKDPTR
        +RIRPSDITINIGK APIPECPIPGERWKEVRHDNTVTWLAFWNDPIN KEFKYVFLAASSSLKGQSDKEKYEKAR+LKDYIKNIRNAYTKDFTSKDPTR
Subjt:  KRIRPSDITINIGKDAPIPECPIPGERWKEVRHDNTVTWLAFWNDPINPKEFKYVFLAASSSLKGQSDKEKYEKARMLKDYIKNIRNAYTKDFTSKDPTR

Query:  RQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVKAVPPNLLEFNFLGKDSIKYENTVEVELPVFKAITQFQSGKSGSDDLFDKLDTSKLNAHLK
        RQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVKAVPPNLLEFNFLGKDSI+YENTVEVELPVFKAITQFQSGKSG+DDLFDKLDT+KLNAHLK
Subjt:  RQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVKAVPPNLLEFNFLGKDSIKYENTVEVELPVFKAITQFQSGKSGSDDLFDKLDTSKLNAHLK

Query:  DLMPGLTAKVFRTYNASITLDDMLNRGTKEGEVAEKIATYQHANKEVAIICNHQRTVSKSHGAQMSRLNEKISELRDILKELKIDLDRAKKGKPPLKDAD
        DLMPGLTAKVFRTYNASITLDDMLNRGTK+GEV+EKI TYQHANKEVAIICNHQRTVSKSHGAQM+RLNEKISELRDILKELKIDLDRAKKGKPPLK +D
Subjt:  DLMPGLTAKVFRTYNASITLDDMLNRGTKEGEVAEKIATYQHANKEVAIICNHQRTVSKSHGAQMSRLNEKISELRDILKELKIDLDRAKKGKPPLKDAD

Query:  GKQKRNLAPEALEKKISQTNVKIEKIERDMQTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFAWAMDVDPDFRF
        GKQKRNL PEALEKKISQTN KIEKIERDM+TKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFAWAMDVDPDFRF
Subjt:  GKQKRNLAPEALEKKISQTNVKIEKIERDMQTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFAWAMDVDPDFRF

XP_022932254.1 DNA topoisomerase 1 beta-like [Cucurbita moschata]

0.0e+00

89.08

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Query:  MAVQTFGKAPMFDDDDEDDVPIVFKRSSASRQNQLDSEAK----QRLNKLTGKQGSDVSSPNGQSSNAQKRTTSLPKASPLKSEIGRQKAPNSSIQAPLA
        MAV+TFGKAPMFDDDDED++PIVFKRSSASRQNQL+SE K    QRLN+L+G+ GSD  S NGQSSNAQKR TSLPK SP++ EIG QKA  SSIQ PL 
Subjt:  MAVQTFGKAPMFDDDDEDDVPIVFKRSSASRQNQLDSEAK----QRLNKLTGKQGSDVSSPNGQSSNAQKRTTSLPKASPLKSEIGRQKAPNSSIQAPLA

Query:  KS-----QLSDSMDSRPKSLANAAVKKEND-IHPAWESSDSEDDKPLSCRLKGNSNLPSKQLTPTVPKNKVKKSSGDSDDEIPLSSKFQMKSASGASGGK
        KS     ++SDSMDSRPK LANAAVK+END IHP  E+SDSEDDKPLS RLKGNSN PSK   PTV KNK+KKSS DSDDE+PLSSKFQMKSASG  GGK
Subjt:  KS-----QLSDSMDSRPKSLANAAVKKEND-IHPAWESSDSEDDKPLSCRLKGNSNLPSKQLTPTVPKNKVKKSSGDSDDEIPLSSKFQMKSASGASGGK

Query:  QHGFDEKNPLVSKVHQNGSTSRDKLQKPAIVYGKRPLPNADSHSSPQLSIKKPKLSDSSTPSSVKIVSLKEKQEVDDDDDDIPISQRMKKMSASVNKQSS
        QHGF EK PL SKVHQNGSTSRDKLQKPA+V  KRPLPNADSHSS Q+S KKPKLSDSSTP S   VSLK KQEV DDDD IPISQRM KMSA+VNK S 
Subjt:  QHGFDEKNPLVSKVHQNGSTSRDKLQKPAIVYGKRPLPNADSHSSPQLSIKKPKLSDSSTPSSVKIVSLKEKQEVDDDDDDIPISQRMKKMSASVNKQSS

Query:  SKQTVSKVASSSIKKTFKKFEKPVKKSKYGKSTKLLPSAGDGQKKWTTLVHNGVIFPPPYQTHRVKMLYKGKPVGLTPEQEEVATMFAVMKDTDYMLKPK
        SK+TVSKVASSSIKKT KK +KPVKKSKY KSTKLLPS+GDGQKKWTTLVHNGVIFPPPYQTH VK+L+KGKPV LT EQEEVATMFAVMKDTDYM KPK
Subjt:  SKQTVSKVASSSIKKTFKKFEKPVKKSKYGKSTKLLPSAGDGQKKWTTLVHNGVIFPPPYQTHRVKMLYKGKPVGLTPEQEEVATMFAVMKDTDYMLKPK

Query:  FKENFWNDWRKILGKNHAIQNLDDCDFTPIYDWYQIEKEKKKQMTSEEKKALKEEKLKQEEKYMWAILDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKK
        FKENFWNDWRK+LGKNH IQNLDDCDFTPIYDWYQ EKEKKKQMT+EEKKALKEEKLKQEEKYMWAILDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKK
Subjt:  FKENFWNDWRKILGKNHAIQNLDDCDFTPIYDWYQIEKEKKKQMTSEEKKALKEEKLKQEEKYMWAILDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKK

Query:  RIRPSDITINIGKDAPIPECPIPGERWKEVRHDNTVTWLAFWNDPINPKEFKYVFLAASSSLKGQSDKEKYEKARMLKDYIKNIRNAYTKDFTSKDPTRR
        RIRPSDITINIGKDAPIPECPIPG+RWKEVRHDNTVTWLAFWNDPINPKEFKYVFLAASSSLKGQSDKEKYEKARMLKDYIKNIRN+YTKDFTSKDPTRR
Subjt:  RIRPSDITINIGKDAPIPECPIPGERWKEVRHDNTVTWLAFWNDPINPKEFKYVFLAASSSLKGQSDKEKYEKARMLKDYIKNIRNAYTKDFTSKDPTRR

Query:  QIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVKAVPPNLLEFNFLGKDSIKYENTVEVELPVFKAITQFQSGKSGSDDLFDKLDTSKLNAHLKD
        QIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVKAVPPNLLEFNFLGKDSIKYENTVEVELPVFKAITQFQSGKSGSDDLFDKLDTSKLNAHLKD
Subjt:  QIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVKAVPPNLLEFNFLGKDSIKYENTVEVELPVFKAITQFQSGKSGSDDLFDKLDTSKLNAHLKD

Query:  LMPGLTAKVFRTYNASITLDDMLNRGTKEGEVAEKIATYQHANKEVAIICNHQRTVSKSHGAQMSRLNEKISELRDILKELKIDLDRAKKGKPPLKDADG
        LMPGLTAKVFRTYNASITLDDMLNRGTK+GEV+EKI TYQHANKEVAIICNHQRTVSKSHGAQM+RLNEKISELRDILKELKIDLDRAKKGKPPLK +DG
Subjt:  LMPGLTAKVFRTYNASITLDDMLNRGTKEGEVAEKIATYQHANKEVAIICNHQRTVSKSHGAQMSRLNEKISELRDILKELKIDLDRAKKGKPPLKDADG

Query:  KQKRNLAPEALEKKISQTNVKIEKIERDMQTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFAWAMDVDPDFRF
        KQKRNL PEALEKKISQTN KIEKIERDM+TKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFAWAMDVDPDFRF
Subjt:  KQKRNLAPEALEKKISQTNVKIEKIERDMQTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFAWAMDVDPDFRF

XP_022940477.1 DNA topoisomerase 1 alpha-like [Cucurbita moschata]

0.0e+00

88.46

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Query:  MAVQTFGKAPMFDDDDEDDVPIVFKRSSASRQNQLDSEAKQRLNKLTGKQGSDVSSPNGQSSNAQKRTTSLPKASPLK-SEIGRQKAPNSSIQAPLAKS-
        MAV+TFGKAPMFD+DDED++PIVFKRSSASRQNQLDSEAKQRLNKL+G+QGSDV SPNGQSSNAQ RTTSLPK SP+K SE+G QKA NSSIQAPL KS 
Subjt:  MAVQTFGKAPMFDDDDEDDVPIVFKRSSASRQNQLDSEAKQRLNKLTGKQGSDVSSPNGQSSNAQKRTTSLPKASPLK-SEIGRQKAPNSSIQAPLAKS-

Query:  ----QLSDSMDSRPKSLANAAVKKENDIHPAWESSDSEDDKPLSCRLKGNSNLPSKQLTPTVPKNKVKKSSGDSDDEIPLSSKFQMKSASGASGGKQHGF
            ++SDS DS+ K L  AAVK+E+D HP  E+SDSEDDKPLS RLKGNSN P K L PTV KNKV+KSSGDSDD IPLSSKF MKS S  SGG QHGF
Subjt:  ----QLSDSMDSRPKSLANAAVKKENDIHPAWESSDSEDDKPLSCRLKGNSNLPSKQLTPTVPKNKVKKSSGDSDDEIPLSSKFQMKSASGASGGKQHGF

Query:  DEKNPLVSKVHQNGSTSRDKLQKPAIVYGKRPLPNADSHSSPQLSIKKPKLSDSSTPSSVKIVSLKEKQEVDDDDDDIPISQRMKKMSASVNKQSSSKQT
        DEK PL+SKVHQNG TS DKLQKP ++  KRPLPNADSHSSPQ S KKPKLSDSSTP   K+VS+K KQEVDDDDD IPISQRMKK++ S NK  SSK+T
Subjt:  DEKNPLVSKVHQNGSTSRDKLQKPAIVYGKRPLPNADSHSSPQLSIKKPKLSDSSTPSSVKIVSLKEKQEVDDDDDDIPISQRMKKMSASVNKQSSSKQT

Query:  VSKVASSSIKKTFKKFEKPVKKSKYGKSTKLLPSAGDGQKKWTTLVHNGVIFPPPYQTHRVKMLYKGKPVGLTPEQEEVATMFAVMKDTDYMLKPKFKEN
        VSKV SSS+KKT KK +KPVKKSKY KSTKLLPS+GDGQKKWT+LVHNGVIFPPPYQTH VKM+YKGK V LTPEQEEVATMFAVMKDTDYM KPKFKEN
Subjt:  VSKVASSSIKKTFKKFEKPVKKSKYGKSTKLLPSAGDGQKKWTTLVHNGVIFPPPYQTHRVKMLYKGKPVGLTPEQEEVATMFAVMKDTDYMLKPKFKEN

Query:  FWNDWRKILGKNHAIQNLDDCDFTPIYDWYQIEKEKKKQMTSEEKKALKEEKLKQEEKYMWAILDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRIRP
        FWNDWRK+LGKNH IQNLDDCDFTPIYDWYQ EKEKKKQMT+EEKKALKEEK+KQEEKYMWAILDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLK+RI P
Subjt:  FWNDWRKILGKNHAIQNLDDCDFTPIYDWYQIEKEKKKQMTSEEKKALKEEKLKQEEKYMWAILDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRIRP

Query:  SDITINIGKDAPIPECPIPGERWKEVRHDNTVTWLAFWNDPINPKEFKYVFLAASSSLKGQSDKEKYEKARMLKDYIKNIRNAYTKDFTSKDPTRRQIAV
         DITINIGKDAPIPECPIPGERWKEVRHDNTVTWLAFWNDPINPKEFKYVFLAASSSLKGQSDKEKYEKAR LKDYIKNIRNAYTKDFTSKDPTRRQIAV
Subjt:  SDITINIGKDAPIPECPIPGERWKEVRHDNTVTWLAFWNDPINPKEFKYVFLAASSSLKGQSDKEKYEKARMLKDYIKNIRNAYTKDFTSKDPTRRQIAV

Query:  ATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVKAVPPNLLEFNFLGKDSIKYENTVEVELPVFKAITQFQSGKSGSDDLFDKLDTSKLNAHLKDLMPG
        ATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVKAVPPNLLEFNFLGKDSIKYENTVEVELPVFKAITQFQSGKSG+DDLFDKLDTSKLNAHLKDLMPG
Subjt:  ATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVKAVPPNLLEFNFLGKDSIKYENTVEVELPVFKAITQFQSGKSGSDDLFDKLDTSKLNAHLKDLMPG

Query:  LTAKVFRTYNASITLDDMLNRGTKEGEVAEKIATYQHANKEVAIICNHQRTVSKSHGAQMSRLNEKISELRDILKELKIDLDRAKKGKPPLKDADGKQKR
        LTAKVFRTYNASITLDDMLNRGTK+G+VAEKI  YQHANKEVAIICNHQRTVSKSHGAQMSRLNEKISELRDILKELKIDLDRAKKGKPPLKDADGKQKR
Subjt:  LTAKVFRTYNASITLDDMLNRGTKEGEVAEKIATYQHANKEVAIICNHQRTVSKSHGAQMSRLNEKISELRDILKELKIDLDRAKKGKPPLKDADGKQKR

Query:  NLAPEALEKKISQTNVKIEKIERDMQTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFAWAMDVDPDFRF
        NL PE LEKKISQTN KIEKIERDMQTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFAWAMDVDPDFRF
Subjt:  NLAPEALEKKISQTNVKIEKIERDMQTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFAWAMDVDPDFRF

XP_023553297.1 DNA topoisomerase 1 beta-like [Cucurbita pepo subsp. pepo]

0.0e+00

88.96

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Query:  MAVQTFGKAPMFDDDDEDDVPIVFKRSSASRQNQLDSEAK----QRLNKLTGKQGSDVSSPNGQSSNAQKRTTSLPKASPLKSEIGRQKAPNSSIQAPLA
        MAV+TFGKAPMFDDDDED++PIVFKRSSASRQNQL+SE K    QRLN+L+G+ GSD  S NGQSSNAQKR TSLPK SP++ EIG QKA  SSIQ PL 
Subjt:  MAVQTFGKAPMFDDDDEDDVPIVFKRSSASRQNQLDSEAK----QRLNKLTGKQGSDVSSPNGQSSNAQKRTTSLPKASPLKSEIGRQKAPNSSIQAPLA

Query:  KS-----QLSDSMDSRPKSLANAAVKKEND-IHPAWESSDSEDDKPLSCRLKGNSNLPSKQLTPTVPKNKVKKSSGDSDDEIPLSSKFQMKSASGASGGK
        KS     ++SDSMDSRPK LANAAVK+END IHP  ++SDSEDDKPLS RLKGNSN PSK   PTV KNK+KKSS DSDDE+PLSSKFQMKSASG  GG+
Subjt:  KS-----QLSDSMDSRPKSLANAAVKKEND-IHPAWESSDSEDDKPLSCRLKGNSNLPSKQLTPTVPKNKVKKSSGDSDDEIPLSSKFQMKSASGASGGK

Query:  QHGFDEKNPLVSKVHQNGSTSRDKLQKPAIVYGKRPLPNADSHSSPQLSIKKPKLSDSSTPSSVKIVSLKEKQEVDDDDDDIPISQRMKKMSASVNKQSS
        QHGFDEK PL SKVHQNGSTSRDKLQKPA+V  KRPLPNADSHSS Q+S KKPKLSDSSTP S   VSLK KQEV DDDD IPISQRM KMSA+VNK S 
Subjt:  QHGFDEKNPLVSKVHQNGSTSRDKLQKPAIVYGKRPLPNADSHSSPQLSIKKPKLSDSSTPSSVKIVSLKEKQEVDDDDDDIPISQRMKKMSASVNKQSS

Query:  SKQTVSKVASSSIKKTFKKFEKPVKKSKYGKSTKLLPSAGDGQKKWTTLVHNGVIFPPPYQTHRVKMLYKGKPVGLTPEQEEVATMFAVMKDTDYMLKPK
        SK+TVSKVASSSIKKT KK +KPVKKSKY KSTKLLPS+GDGQKKWTTLVHNGVIFPPPYQTH VK+L+KGKPV LTPEQEEVATMFAVMKDTDYM KPK
Subjt:  SKQTVSKVASSSIKKTFKKFEKPVKKSKYGKSTKLLPSAGDGQKKWTTLVHNGVIFPPPYQTHRVKMLYKGKPVGLTPEQEEVATMFAVMKDTDYMLKPK

Query:  FKENFWNDWRKILGKNHAIQNLDDCDFTPIYDWYQIEKEKKKQMTSEEKKALKEEKLKQEEKYMWAILDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKK
        FKENFWNDWRK+LGKNH IQNLDDCDFTPIYDWYQ EKEKKKQMT+EEKKALKEEKLKQEEKYMWAILDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKK
Subjt:  FKENFWNDWRKILGKNHAIQNLDDCDFTPIYDWYQIEKEKKKQMTSEEKKALKEEKLKQEEKYMWAILDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKK

Query:  RIRPSDITINIGKDAPIPECPIPGERWKEVRHDNTVTWLAFWNDPINPKEFKYVFLAASSSLKGQSDKEKYEKARMLKDYIKNIRNAYTKDFTSKDPTRR
        RIRPSDITINIGKDAPIPECPIPG+RWKEVRHDNTVTWLAFWNDPINPKEFKYVFLAASSSLKGQSDKEKYEKARMLKDYIKNIRN+YTKDFTSKDPTRR
Subjt:  RIRPSDITINIGKDAPIPECPIPGERWKEVRHDNTVTWLAFWNDPINPKEFKYVFLAASSSLKGQSDKEKYEKARMLKDYIKNIRNAYTKDFTSKDPTRR

Query:  QIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVKAVPPNLLEFNFLGKDSIKYENTVEVELPVFKAITQFQSGKSGSDDLFDKLDTSKLNAHLKD
        QIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVKAVPPNLLEFNFLGKDSIKYENTVEVELPVFKAITQFQSGKSGSDDLFDKLDTSKLNAHLKD
Subjt:  QIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVKAVPPNLLEFNFLGKDSIKYENTVEVELPVFKAITQFQSGKSGSDDLFDKLDTSKLNAHLKD

Query:  LMPGLTAKVFRTYNASITLDDMLNRGTKEGEVAEKIATYQHANKEVAIICNHQRTVSKSHGAQMSRLNEKISELRDILKELKIDLDRAKKGKPPLKDADG
        LMPGLTAKVFRTYNASITLDDMLNRGTK+GEV+EKI TYQHANKEVAIICNHQRTVSKSHGAQM+RLNEKISELRDI+KELKIDLDRAKKGKPPLK +DG
Subjt:  LMPGLTAKVFRTYNASITLDDMLNRGTKEGEVAEKIATYQHANKEVAIICNHQRTVSKSHGAQMSRLNEKISELRDILKELKIDLDRAKKGKPPLKDADG

Query:  KQKRNLAPEALEKKISQTNVKIEKIERDMQTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFAWAMDVDPDFRF
        KQKRNL PEALEKKISQTN KIEKIERDM+TKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFAWAMDVDPDFRF
Subjt:  KQKRNLAPEALEKKISQTNVKIEKIERDMQTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFAWAMDVDPDFRF

TrEMBL top hits

e value

%identity

Alignment

A0A1S3BM72 DNA topoisomerase I

0.0e+00

88.64

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Query:  MAVQTFGKAPMFDDDDEDDVPIVFKRSSASRQNQLDSEAK----QRLNKLTGKQGSDVSSPNGQSSNAQKRTTSLPKASPLKSEIGRQKAPNSS-IQAPL
        MAV+TFGKAPMFDDDDED++PIVFKRSSASRQNQLDSE K    QRLNKL G+QGSD+ S NGQSSN QKR TSLPK SP++SEIG QKAP SS IQ PL
Subjt:  MAVQTFGKAPMFDDDDEDDVPIVFKRSSASRQNQLDSEAK----QRLNKLTGKQGSDVSSPNGQSSNAQKRTTSLPKASPLKSEIGRQKAPNSS-IQAPL

Query:  AKS-----QLSDSMDSRPKSLANAAVKKEN-DIHPAWESSDSEDDKPLSCRLKGNSNLPSKQLTPTVPKNKVKKSSGDSDDEIPLSSKFQMKSASGASGG
         KS     + SDSMDSRPK+L NAAVK+EN  I+P+ E+SDSEDDKPLS RLKGNSN P+K L  T+PKNKVKKSSGDSDDE+PLSSKFQMK ASG  G 
Subjt:  AKS-----QLSDSMDSRPKSLANAAVKKEN-DIHPAWESSDSEDDKPLSCRLKGNSNLPSKQLTPTVPKNKVKKSSGDSDDEIPLSSKFQMKSASGASGG

Query:  KQHGFDEKNPLVSKVHQNGSTSRDKLQKPAIVYGKRPLPNADSHSSPQLSIKKPKLSDSSTPSSVKIVSLKEKQEVDDDDDDIPISQRMKKMSASVNKQS
        KQ GFDEK PLV KVHQNGSTSRDKLQKPA++  KRPLPN DSHS  Q S KKPKLSDSS+P S K+VSLK KQEVDDDDDDIPISQR+KK  A+VNK S
Subjt:  KQHGFDEKNPLVSKVHQNGSTSRDKLQKPAIVYGKRPLPNADSHSSPQLSIKKPKLSDSSTPSSVKIVSLKEKQEVDDDDDDIPISQRMKKMSASVNKQS

Query:  SSKQTVSKVASSSIKKTFKKFEKPVKKSKYGKSTKLLPSAGDGQKKWTTLVHNGVIFPPPYQTHRVKMLYKGKPVGLTPEQEEVATMFAVMKDTDYMLKP
        SSK TVSKV SSSIKKTFKK +KPVKKSKY KSTKLLPSAGDGQKKWTTLVHNGVIFPPPYQTH VKMLYKGKPV LTP+QEEVATMFAVMKDTDYMLKP
Subjt:  SSKQTVSKVASSSIKKTFKKFEKPVKKSKYGKSTKLLPSAGDGQKKWTTLVHNGVIFPPPYQTHRVKMLYKGKPVGLTPEQEEVATMFAVMKDTDYMLKP

Query:  KFKENFWNDWRKILGKNHAIQNLDDCDFTPIYDWYQIEKEKKKQMTSEEKKALKEEKLKQEEKYMWAILDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLK
        KFKENFWNDWRK+LGKNH IQNLDDCDFTPIYDWYQ+EKEKKKQMT+EEKKALKEEKLKQEEKYMWAILDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLK
Subjt:  KFKENFWNDWRKILGKNHAIQNLDDCDFTPIYDWYQIEKEKKKQMTSEEKKALKEEKLKQEEKYMWAILDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLK

Query:  KRIRPSDITINIGKDAPIPECPIPGERWKEVRHDNTVTWLAFWNDPINPKEFKYVFLAASSSLKGQSDKEKYEKARMLKDYIKNIRNAYTKDFTSKDPTR
        +RIRPSDITINIGK APIPECPIPGERWKEVRHDNTVTWLAFWNDPIN KEFKYVFLAASSSLKGQSDKEKYEKAR+LKDYIKNIRNAYTKDFTSKDPTR
Subjt:  KRIRPSDITINIGKDAPIPECPIPGERWKEVRHDNTVTWLAFWNDPINPKEFKYVFLAASSSLKGQSDKEKYEKARMLKDYIKNIRNAYTKDFTSKDPTR

Query:  RQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVKAVPPNLLEFNFLGKDSIKYENTVEVELPVFKAITQFQSGKSGSDDLFDKLDTSKLNAHLK
        RQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVKAVPPNLLEFNFLGKDSI+YENTVEVELPVFKAITQFQSGKSG+DDLFDKLDT+KLNAHLK
Subjt:  RQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVKAVPPNLLEFNFLGKDSIKYENTVEVELPVFKAITQFQSGKSGSDDLFDKLDTSKLNAHLK

Query:  DLMPGLTAKVFRTYNASITLDDMLNRGTKEGEVAEKIATYQHANKEVAIICNHQRTVSKSHGAQMSRLNEKISELRDILKELKIDLDRAKKGKPPLKDAD
        DLMPGLTAKVFRTYNASITLDDMLNRGTK+GEV+EKI TYQHANKEVAIICNHQRTVSKSHGAQM+RLNEKISELRDILKELKIDLDRAKKGKPPLK +D
Subjt:  DLMPGLTAKVFRTYNASITLDDMLNRGTKEGEVAEKIATYQHANKEVAIICNHQRTVSKSHGAQMSRLNEKISELRDILKELKIDLDRAKKGKPPLKDAD

Query:  GKQKRNLAPEALEKKISQTNVKIEKIERDMQTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFAWAMDVDPDFRF
        GKQKRNL PEALEKKISQTN KIEKIERDM+TKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFAWAMDVDPDFRF
Subjt:  GKQKRNLAPEALEKKISQTNVKIEKIERDMQTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFAWAMDVDPDFRF

A0A5A7VHI9 DNA topoisomerase I

0.0e+00

86.88

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Query:  MAVQTFGKAPMFDDDDEDDVPIVFKRSSASRQNQLDSEAK----QRLNKLTGKQGSDVSSPNGQSSNAQKRTTSLPKASPLKSEIGRQKAPNSS-IQAPL
        MAV+TFGKAPMFDDDDED++PIVFKRSSASRQNQLDSE K    QRLNKL G+QGSD+ S NGQSSN QKR TSLPK SP++SEIG QKAP SS IQ PL
Subjt:  MAVQTFGKAPMFDDDDEDDVPIVFKRSSASRQNQLDSEAK----QRLNKLTGKQGSDVSSPNGQSSNAQKRTTSLPKASPLKSEIGRQKAPNSS-IQAPL

Query:  AKS-----QLSDSMDSRPKSLANAAVKKEN-DIHPAWESSDSEDDKPLSCRLKGNSNLPSKQLTPTVPKNKVKKSSGDSDDEIPLSSKFQMKSASGASGG
         KS     + SDSMDSRPK+L NAAVK+EN  I+P+ E+SDSEDDKPLS RLKGNSN P+K L  T+PKNKVKKSSGDSDDE+PLSSKFQMK ASG  G 
Subjt:  AKS-----QLSDSMDSRPKSLANAAVKKEN-DIHPAWESSDSEDDKPLSCRLKGNSNLPSKQLTPTVPKNKVKKSSGDSDDEIPLSSKFQMKSASGASGG

Query:  KQHGFDEKNPLVSKVHQNGSTSRDKLQKPAIVYGKRPLPNADSHSSPQLSIKKPKLSDSSTPSSVKIVSLKEKQEVDDDDDDIPISQRMKKMSASVNKQS
        KQ GFDEK PLV KVHQNGSTSRDKLQKPA++  KRPLPN DSHS  Q S KKPKLSDSS+P S K+VSLK KQEVDDDDDDIPISQR+KK  A+VNK S
Subjt:  KQHGFDEKNPLVSKVHQNGSTSRDKLQKPAIVYGKRPLPNADSHSSPQLSIKKPKLSDSSTPSSVKIVSLKEKQEVDDDDDDIPISQRMKKMSASVNKQS

Query:  SSKQTVSKVASSSIKKTFKKFEKPVKKSKYGKSTKLLPSAGDGQKKWTTLVHNGVIFPPPYQTHRVKMLYKGKPVGLTPEQEEVATMFAVMKDTDYMLKP
        SSK TVSKV SSSIKKTFKK +KPVKKSKY KSTKLLPSAGDGQKKWTTLVHNGVIFPPPYQTH VKMLYKGKPV LTP+QEEVATMFAVMKDTDYMLKP
Subjt:  SSKQTVSKVASSSIKKTFKKFEKPVKKSKYGKSTKLLPSAGDGQKKWTTLVHNGVIFPPPYQTHRVKMLYKGKPVGLTPEQEEVATMFAVMKDTDYMLKP

Query:  KFKENFWNDWRKILGKNHAIQNLDDCDFTPIYDWYQIEKEKKKQMTSEEKKALKEEKLKQEEKYMWAILDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLK
        KFKENFWNDWRK+LGKNH IQNLDDCDFTPIYDWYQ+EKEKKKQMT+EEKKALKEEKLKQEEKYMWAILDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLK
Subjt:  KFKENFWNDWRKILGKNHAIQNLDDCDFTPIYDWYQIEKEKKKQMTSEEKKALKEEKLKQEEKYMWAILDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLK

Query:  KRIRPSDITINIGKDAPIPECPIPGERWKEVRHDNTVTWLAFWNDPINPKEFKYVFLAASSSLKGQSDKEKYEKARMLKDYIKNIRNAYTKDFTSKDPTR
        +RIRPSDITINIGK APIPECPIPGERWKEVRHDNTVTWLAFWNDPIN KEFKYVFLAASSSLKGQSDKEKYEKAR+LKDYIKNIRNAYTKDFTSKDPTR
Subjt:  KRIRPSDITINIGKDAPIPECPIPGERWKEVRHDNTVTWLAFWNDPINPKEFKYVFLAASSSLKGQSDKEKYEKARMLKDYIKNIRNAYTKDFTSKDPTR

Query:  RQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVKAVPPNLLEFNFLGKDSIKYENTVEVELPVFKAITQFQSGKSGSDDLFDKLDTSKLNAHLK
        RQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVKAVPPNLLEFNFLGKDSI+YENTVEVELPVFKAITQFQSGKSG+DDLFDKLDT+KLNAHLK
Subjt:  RQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVKAVPPNLLEFNFLGKDSIKYENTVEVELPVFKAITQFQSGKSGSDDLFDKLDTSKLNAHLK

Query:  DLMPGLTAKVFRTYNASITLDDMLNRGTKEGEVAEKIATYQHANKEVAIICNHQRTVSKSHGAQMSRLNEKISELRDILKELKIDLDRAKKGKPPLKDAD
        DLMPGLTAKVFRTYNASITLDDMLNRGTK+GEV+EKI TYQHANKEVAIICNHQRTVSKSHGAQM+RLNEKISELRDILKELKIDLDRAKKGKPPLK +D
Subjt:  DLMPGLTAKVFRTYNASITLDDMLNRGTKEGEVAEKIATYQHANKEVAIICNHQRTVSKSHGAQMSRLNEKISELRDILKELKIDLDRAKKGKPPLKDAD

Query:  GKQKRNLAPEALEKKISQTNVKIEKIERDMQTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEK------------------IFNKSLLAKFAWAMD
        GKQKRNL PEALEKKISQTN KIEKIERDM+TKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEK                  IFNKSLLAKFAWAMD
Subjt:  GKQKRNLAPEALEKKISQTNVKIEKIERDMQTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEK------------------IFNKSLLAKFAWAMD

Query:  VDPDFRF
        VDPDFRF
Subjt:  VDPDFRF

A0A6J1EWI0 DNA topoisomerase I

0.0e+00

89.08

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Query:  MAVQTFGKAPMFDDDDEDDVPIVFKRSSASRQNQLDSEAK----QRLNKLTGKQGSDVSSPNGQSSNAQKRTTSLPKASPLKSEIGRQKAPNSSIQAPLA
        MAV+TFGKAPMFDDDDED++PIVFKRSSASRQNQL+SE K    QRLN+L+G+ GSD  S NGQSSNAQKR TSLPK SP++ EIG QKA  SSIQ PL 
Subjt:  MAVQTFGKAPMFDDDDEDDVPIVFKRSSASRQNQLDSEAK----QRLNKLTGKQGSDVSSPNGQSSNAQKRTTSLPKASPLKSEIGRQKAPNSSIQAPLA

Query:  KS-----QLSDSMDSRPKSLANAAVKKEND-IHPAWESSDSEDDKPLSCRLKGNSNLPSKQLTPTVPKNKVKKSSGDSDDEIPLSSKFQMKSASGASGGK
        KS     ++SDSMDSRPK LANAAVK+END IHP  E+SDSEDDKPLS RLKGNSN PSK   PTV KNK+KKSS DSDDE+PLSSKFQMKSASG  GGK
Subjt:  KS-----QLSDSMDSRPKSLANAAVKKEND-IHPAWESSDSEDDKPLSCRLKGNSNLPSKQLTPTVPKNKVKKSSGDSDDEIPLSSKFQMKSASGASGGK

Query:  QHGFDEKNPLVSKVHQNGSTSRDKLQKPAIVYGKRPLPNADSHSSPQLSIKKPKLSDSSTPSSVKIVSLKEKQEVDDDDDDIPISQRMKKMSASVNKQSS
        QHGF EK PL SKVHQNGSTSRDKLQKPA+V  KRPLPNADSHSS Q+S KKPKLSDSSTP S   VSLK KQEV DDDD IPISQRM KMSA+VNK S 
Subjt:  QHGFDEKNPLVSKVHQNGSTSRDKLQKPAIVYGKRPLPNADSHSSPQLSIKKPKLSDSSTPSSVKIVSLKEKQEVDDDDDDIPISQRMKKMSASVNKQSS

Query:  SKQTVSKVASSSIKKTFKKFEKPVKKSKYGKSTKLLPSAGDGQKKWTTLVHNGVIFPPPYQTHRVKMLYKGKPVGLTPEQEEVATMFAVMKDTDYMLKPK
        SK+TVSKVASSSIKKT KK +KPVKKSKY KSTKLLPS+GDGQKKWTTLVHNGVIFPPPYQTH VK+L+KGKPV LT EQEEVATMFAVMKDTDYM KPK
Subjt:  SKQTVSKVASSSIKKTFKKFEKPVKKSKYGKSTKLLPSAGDGQKKWTTLVHNGVIFPPPYQTHRVKMLYKGKPVGLTPEQEEVATMFAVMKDTDYMLKPK

Query:  FKENFWNDWRKILGKNHAIQNLDDCDFTPIYDWYQIEKEKKKQMTSEEKKALKEEKLKQEEKYMWAILDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKK
        FKENFWNDWRK+LGKNH IQNLDDCDFTPIYDWYQ EKEKKKQMT+EEKKALKEEKLKQEEKYMWAILDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKK
Subjt:  FKENFWNDWRKILGKNHAIQNLDDCDFTPIYDWYQIEKEKKKQMTSEEKKALKEEKLKQEEKYMWAILDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKK

Query:  RIRPSDITINIGKDAPIPECPIPGERWKEVRHDNTVTWLAFWNDPINPKEFKYVFLAASSSLKGQSDKEKYEKARMLKDYIKNIRNAYTKDFTSKDPTRR
        RIRPSDITINIGKDAPIPECPIPG+RWKEVRHDNTVTWLAFWNDPINPKEFKYVFLAASSSLKGQSDKEKYEKARMLKDYIKNIRN+YTKDFTSKDPTRR
Subjt:  RIRPSDITINIGKDAPIPECPIPGERWKEVRHDNTVTWLAFWNDPINPKEFKYVFLAASSSLKGQSDKEKYEKARMLKDYIKNIRNAYTKDFTSKDPTRR

Query:  QIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVKAVPPNLLEFNFLGKDSIKYENTVEVELPVFKAITQFQSGKSGSDDLFDKLDTSKLNAHLKD
        QIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVKAVPPNLLEFNFLGKDSIKYENTVEVELPVFKAITQFQSGKSGSDDLFDKLDTSKLNAHLKD
Subjt:  QIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVKAVPPNLLEFNFLGKDSIKYENTVEVELPVFKAITQFQSGKSGSDDLFDKLDTSKLNAHLKD

Query:  LMPGLTAKVFRTYNASITLDDMLNRGTKEGEVAEKIATYQHANKEVAIICNHQRTVSKSHGAQMSRLNEKISELRDILKELKIDLDRAKKGKPPLKDADG
        LMPGLTAKVFRTYNASITLDDMLNRGTK+GEV+EKI TYQHANKEVAIICNHQRTVSKSHGAQM+RLNEKISELRDILKELKIDLDRAKKGKPPLK +DG
Subjt:  LMPGLTAKVFRTYNASITLDDMLNRGTKEGEVAEKIATYQHANKEVAIICNHQRTVSKSHGAQMSRLNEKISELRDILKELKIDLDRAKKGKPPLKDADG

Query:  KQKRNLAPEALEKKISQTNVKIEKIERDMQTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFAWAMDVDPDFRF
        KQKRNL PEALEKKISQTN KIEKIERDM+TKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFAWAMDVDPDFRF
Subjt:  KQKRNLAPEALEKKISQTNVKIEKIERDMQTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFAWAMDVDPDFRF

A0A6J1FIM6 DNA topoisomerase I

0.0e+00

88.46

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Query:  MAVQTFGKAPMFDDDDEDDVPIVFKRSSASRQNQLDSEAKQRLNKLTGKQGSDVSSPNGQSSNAQKRTTSLPKASPLK-SEIGRQKAPNSSIQAPLAKS-
        MAV+TFGKAPMFD+DDED++PIVFKRSSASRQNQLDSEAKQRLNKL+G+QGSDV SPNGQSSNAQ RTTSLPK SP+K SE+G QKA NSSIQAPL KS 
Subjt:  MAVQTFGKAPMFDDDDEDDVPIVFKRSSASRQNQLDSEAKQRLNKLTGKQGSDVSSPNGQSSNAQKRTTSLPKASPLK-SEIGRQKAPNSSIQAPLAKS-

Query:  ----QLSDSMDSRPKSLANAAVKKENDIHPAWESSDSEDDKPLSCRLKGNSNLPSKQLTPTVPKNKVKKSSGDSDDEIPLSSKFQMKSASGASGGKQHGF
            ++SDS DS+ K L  AAVK+E+D HP  E+SDSEDDKPLS RLKGNSN P K L PTV KNKV+KSSGDSDD IPLSSKF MKS S  SGG QHGF
Subjt:  ----QLSDSMDSRPKSLANAAVKKENDIHPAWESSDSEDDKPLSCRLKGNSNLPSKQLTPTVPKNKVKKSSGDSDDEIPLSSKFQMKSASGASGGKQHGF

Query:  DEKNPLVSKVHQNGSTSRDKLQKPAIVYGKRPLPNADSHSSPQLSIKKPKLSDSSTPSSVKIVSLKEKQEVDDDDDDIPISQRMKKMSASVNKQSSSKQT
        DEK PL+SKVHQNG TS DKLQKP ++  KRPLPNADSHSSPQ S KKPKLSDSSTP   K+VS+K KQEVDDDDD IPISQRMKK++ S NK  SSK+T
Subjt:  DEKNPLVSKVHQNGSTSRDKLQKPAIVYGKRPLPNADSHSSPQLSIKKPKLSDSSTPSSVKIVSLKEKQEVDDDDDDIPISQRMKKMSASVNKQSSSKQT

Query:  VSKVASSSIKKTFKKFEKPVKKSKYGKSTKLLPSAGDGQKKWTTLVHNGVIFPPPYQTHRVKMLYKGKPVGLTPEQEEVATMFAVMKDTDYMLKPKFKEN
        VSKV SSS+KKT KK +KPVKKSKY KSTKLLPS+GDGQKKWT+LVHNGVIFPPPYQTH VKM+YKGK V LTPEQEEVATMFAVMKDTDYM KPKFKEN
Subjt:  VSKVASSSIKKTFKKFEKPVKKSKYGKSTKLLPSAGDGQKKWTTLVHNGVIFPPPYQTHRVKMLYKGKPVGLTPEQEEVATMFAVMKDTDYMLKPKFKEN

Query:  FWNDWRKILGKNHAIQNLDDCDFTPIYDWYQIEKEKKKQMTSEEKKALKEEKLKQEEKYMWAILDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRIRP
        FWNDWRK+LGKNH IQNLDDCDFTPIYDWYQ EKEKKKQMT+EEKKALKEEK+KQEEKYMWAILDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLK+RI P
Subjt:  FWNDWRKILGKNHAIQNLDDCDFTPIYDWYQIEKEKKKQMTSEEKKALKEEKLKQEEKYMWAILDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRIRP

Query:  SDITINIGKDAPIPECPIPGERWKEVRHDNTVTWLAFWNDPINPKEFKYVFLAASSSLKGQSDKEKYEKARMLKDYIKNIRNAYTKDFTSKDPTRRQIAV
         DITINIGKDAPIPECPIPGERWKEVRHDNTVTWLAFWNDPINPKEFKYVFLAASSSLKGQSDKEKYEKAR LKDYIKNIRNAYTKDFTSKDPTRRQIAV
Subjt:  SDITINIGKDAPIPECPIPGERWKEVRHDNTVTWLAFWNDPINPKEFKYVFLAASSSLKGQSDKEKYEKARMLKDYIKNIRNAYTKDFTSKDPTRRQIAV

Query:  ATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVKAVPPNLLEFNFLGKDSIKYENTVEVELPVFKAITQFQSGKSGSDDLFDKLDTSKLNAHLKDLMPG
        ATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVKAVPPNLLEFNFLGKDSIKYENTVEVELPVFKAITQFQSGKSG+DDLFDKLDTSKLNAHLKDLMPG
Subjt:  ATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVKAVPPNLLEFNFLGKDSIKYENTVEVELPVFKAITQFQSGKSGSDDLFDKLDTSKLNAHLKDLMPG

Query:  LTAKVFRTYNASITLDDMLNRGTKEGEVAEKIATYQHANKEVAIICNHQRTVSKSHGAQMSRLNEKISELRDILKELKIDLDRAKKGKPPLKDADGKQKR
        LTAKVFRTYNASITLDDMLNRGTK+G+VAEKI  YQHANKEVAIICNHQRTVSKSHGAQMSRLNEKISELRDILKELKIDLDRAKKGKPPLKDADGKQKR
Subjt:  LTAKVFRTYNASITLDDMLNRGTKEGEVAEKIATYQHANKEVAIICNHQRTVSKSHGAQMSRLNEKISELRDILKELKIDLDRAKKGKPPLKDADGKQKR

Query:  NLAPEALEKKISQTNVKIEKIERDMQTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFAWAMDVDPDFRF
        NL PE LEKKISQTN KIEKIERDMQTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFAWAMDVDPDFRF
Subjt:  NLAPEALEKKISQTNVKIEKIERDMQTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFAWAMDVDPDFRF

A0A6J1KZE0 DNA topoisomerase I

0.0e+00

88.96

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Query:  MAVQTFGKAPMFDDDDEDDVPIVFKRSSASRQNQLDSEAK----QRLNKLTGKQGSDVSSPNGQSSNAQKRTTSLPKASPLKSEIGRQKAPNSSIQAPLA
        MAV+TFGKA MFDDDDED++PIVFKRSSASRQNQL+SE K    QRLN+L+G+ GSD  S NGQSSNAQKR TSLPK SP++ EIG QKA  SSIQ PL 
Subjt:  MAVQTFGKAPMFDDDDEDDVPIVFKRSSASRQNQLDSEAK----QRLNKLTGKQGSDVSSPNGQSSNAQKRTTSLPKASPLKSEIGRQKAPNSSIQAPLA

Query:  KS-----QLSDSMDSRPKSLANAAVKKEND-IHPAWESSDSEDDKPLSCRLKGNSNLPSKQLTPTVPKNKVKKSSGDSDDEIPLSSKFQMKSASGASGGK
        KS     ++SDSMDSRPK L NAAVK+END IHPA E+SDSEDDKPLS RLKGNSN PSK   PTV KNK+KKSS DSDDE+PLSSKF+MKSASG  GGK
Subjt:  KS-----QLSDSMDSRPKSLANAAVKKEND-IHPAWESSDSEDDKPLSCRLKGNSNLPSKQLTPTVPKNKVKKSSGDSDDEIPLSSKFQMKSASGASGGK

Query:  QHGFDEKNPLVSKVHQNGSTSRDKLQKPAIVYGKRPLPNADSHSSPQLSIKKPKLSDSSTPSSVKIVSLKEKQEVDDDDDDIPISQRMKKMSASVNKQSS
        QHGFDEK PL SKVHQNGSTS DKLQKPA+V  KRPLPNADSHSS Q+S KKPKLSDSSTP S   VSLK KQEV DDDD IPISQRM KMSA+VNK S 
Subjt:  QHGFDEKNPLVSKVHQNGSTSRDKLQKPAIVYGKRPLPNADSHSSPQLSIKKPKLSDSSTPSSVKIVSLKEKQEVDDDDDDIPISQRMKKMSASVNKQSS

Query:  SKQTVSKVASSSIKKTFKKFEKPVKKSKYGKSTKLLPSAGDGQKKWTTLVHNGVIFPPPYQTHRVKMLYKGKPVGLTPEQEEVATMFAVMKDTDYMLKPK
        SK+TVSKVASSSIKKT KK +KPVKKSKY KSTKLLPS+GDGQKKWTTLVHNGVIFPPPYQTH VK+L+KGKPV LTPEQEEVATMFAVMKDTDYM KPK
Subjt:  SKQTVSKVASSSIKKTFKKFEKPVKKSKYGKSTKLLPSAGDGQKKWTTLVHNGVIFPPPYQTHRVKMLYKGKPVGLTPEQEEVATMFAVMKDTDYMLKPK

Query:  FKENFWNDWRKILGKNHAIQNLDDCDFTPIYDWYQIEKEKKKQMTSEEKKALKEEKLKQEEKYMWAILDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKK
        FKENFWNDWRK+LGKNH IQNLDDCDFTPIYDWYQ EKEKKKQMT+EEKKALKEEKLKQEEKYMWAILDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKK
Subjt:  FKENFWNDWRKILGKNHAIQNLDDCDFTPIYDWYQIEKEKKKQMTSEEKKALKEEKLKQEEKYMWAILDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKK

Query:  RIRPSDITINIGKDAPIPECPIPGERWKEVRHDNTVTWLAFWNDPINPKEFKYVFLAASSSLKGQSDKEKYEKARMLKDYIKNIRNAYTKDFTSKDPTRR
        RIRPSDITINIGKDAPIPECPIPG+RWKEVRHDNTVTWLAFWNDPINPKEFKYVFLAASSSLKGQSDKEKYEKARMLKDYIKNIRN+YTKDFTSKDPTRR
Subjt:  RIRPSDITINIGKDAPIPECPIPGERWKEVRHDNTVTWLAFWNDPINPKEFKYVFLAASSSLKGQSDKEKYEKARMLKDYIKNIRNAYTKDFTSKDPTRR

Query:  QIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVKAVPPNLLEFNFLGKDSIKYENTVEVELPVFKAITQFQSGKSGSDDLFDKLDTSKLNAHLKD
        QIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVKAVPPNLLEFNFLGKDSIKYENTVEVELPVFKAITQFQSGKSGSDDLFDKLDTSKLNAHLKD
Subjt:  QIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVKAVPPNLLEFNFLGKDSIKYENTVEVELPVFKAITQFQSGKSGSDDLFDKLDTSKLNAHLKD

Query:  LMPGLTAKVFRTYNASITLDDMLNRGTKEGEVAEKIATYQHANKEVAIICNHQRTVSKSHGAQMSRLNEKISELRDILKELKIDLDRAKKGKPPLKDADG
        LMPGLTAKVFRTYNASITLDDMLNRGTK+GEV+EKI TYQHANKEVAIICNHQRTVSKSHGAQM+RLNEKISELRDILKELKIDLDRAKKGKPPLK +DG
Subjt:  LMPGLTAKVFRTYNASITLDDMLNRGTKEGEVAEKIATYQHANKEVAIICNHQRTVSKSHGAQMSRLNEKISELRDILKELKIDLDRAKKGKPPLKDADG

Query:  KQKRNLAPEALEKKISQTNVKIEKIERDMQTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFAWAMDVDPDFRF
        KQKRNL PEALEKKISQTN KIEKIERDM+TKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFAWAMDVDPDFRF
Subjt:  KQKRNLAPEALEKKISQTNVKIEKIERDMQTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFAWAMDVDPDFRF

SwissProt top hits

e value

%identity

Alignment

P07799 DNA topoisomerase 1

4.3e-148

40.05

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Query:  SDSMDSRPKSLANAAVKKENDIHPAWESSDSEDDKPLSCRLKGNSNLPSKQLTPTVPKNKVKKSSGDSDDEIPLSSK--FQMKSASGASGGKQHGFDEKN
        SDS+    +        K   +  + E SDS ++ PLS  L                 NK  KS  D DD IP+  +     K+ S +S  K+       
Subjt:  SDSMDSRPKSLANAAVKKENDIHPAWESSDSEDDKPLSCRLKGNSNLPSKQLTPTVPKNKVKKSSGDSDDEIPLSSK--FQMKSASGASGGKQHGFDEKN

Query:  PLVSKVHQNGSTSRDKLQKPAIVYGKRPLPNADSHSSPQLSIKKPKLSDSSTPSSVKIVSLKEKQEVDDDDDDIPISQRMKKMSASVNKQSSSKQTVSKV
           +KV  NG     K  K A+V  +         S     + K   S +   S+V       K+E  D DD +P+       + S    +  K  +   
Subjt:  PLVSKVHQNGSTSRDKLQKPAIVYGKRPLPNADSHSSPQLSIKKPKLSDSSTPSSVKIVSLKEKQEVDDDDDDIPISQRMKKMSASVNKQSSSKQTVSKV

Query:  ASSSIKKTFKKFEKPVKKSKYGKSTKLLPSAGDGQKKWTTLVHNGVIFPPPYQ--THRVKMLYKGKPVGLTPEQEEVATMFAVMKDTDYMLKPKFKENFW
        AS++  ++    E   +  K+  S  +     D  +KWTTL HNGVIF PPY+     VK++Y G PV L PE EEVA  +A M +TD+   P F++NF+
Subjt:  ASSSIKKTFKKFEKPVKKSKYGKSTKLLPSAGDGQKKWTTLVHNGVIFPPPYQ--THRVKMLYKGKPVGLTPEQEEVATMFAVMKDTDYMLKPKFKENFW

Query:  NDWRKILGK---NHAIQNLDDCDFTPIYDWYQIEKEKKKQMTSEEKKALKEEKLKQEEKYMWAILDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRIR
         D+ K+  +   NH I+    CDFT ++  ++ ++E+KK M  E+KKA+K++K ++EEKY W ILDG KEKVGNFR+EPPGLFRGRG HPK G LK+R+ 
Subjt:  NDWRKILGK---NHAIQNLDDCDFTPIYDWYQIEKEKKKQMTSEEKKALKEEKLKQEEKYMWAILDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRIR

Query:  PSDITINIGKDAPIPECPIPGERWKEVRHDNTVTWLAFWNDPINPKEFKYVFLAASSSLKGQSDKEKYEKARMLKDYIKNIRNAYTKDFTSKDPTRRQIA
        P  ITINIG+  P+PE P+PG +W EV+HDNTVTWLA W++ IN    KYVFLAA SSLKGQSD +KYEK+R LKDYI +IR  Y KD  S+    RQ  
Subjt:  PSDITINIGKDAPIPECPIPGERWKEVRHDNTVTWLAFWNDPINPKEFKYVFLAASSSLKGQSDKEKYEKARMLKDYIKNIRNAYTKDFTSKDPTRRQIA

Query:  VATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVKAVPPNLLEFNFLGKDSIKYENTVEVELPVFKAITQF-QSGKSGSDDLFDKLDTSKLNAHLKDLM
         A YLID  ALRAGNEK +DEADTVGCC+L+ E+V   PP  + F+FLGKDSI+Y N VEV+  VFK +  F +  K   D +FD+L T+ LN +L  LM
Subjt:  VATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVKAVPPNLLEFNFLGKDSIKYENTVEVELPVFKAITQF-QSGKSGSDDLFDKLDTSKLNAHLKDLM

Query:  PGLTAKVFRTYNASITLDDMLNRGTKEGEVAEKIATYQHANKEVAIICNHQRTVSKSHGAQMSRLNEKISEL---RDILKELKIDLD-RAKKGKPPL---
         GL+AKVFRTYNAS T+ + L +  K   +A+KI  Y  AN+ VAI+CNHQR+V+K+H  QM R  E+I  L   R  L+++ ++L+ +  K KP L   
Subjt:  PGLTAKVFRTYNASITLDDMLNRGTKEGEVAEKIATYQHANKEVAIICNHQRTVSKSHGAQMSRLNEKISEL---RDILKELKIDLD-RAKKGKPPL---

Query:  --------------------------------------------------------------KDADGKQKR----NLAPEALEKKISQTNVKIEKIERDM
                                                                       DA+ K K+      + E LEK++++ N +I  +   M
Subjt:  --------------------------------------------------------------KDADGKQKR----NLAPEALEKKISQTNVKIEKIERDM

Query:  QTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFAWAMDVDPDFRF
          K++ KT ALGTSKINY+DPR+T ++ KR +VPIEK+F+K++  KF WA D  PD+++
Subjt:  QTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFAWAMDVDPDFRF

P30181 DNA topoisomerase 1 alpha

1.1e-297

60.66

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Query:  MAVQTFGKAPMFDD---DDEDDVPIVFKRSS--ASRQNQLDSEAKQRLNKLTGK---QGSDVSSPNGQSSNAQKRTTSLPKASPLKSEIGRQKAPNSSIQ
        M  +T  K P+ D+   D +DD P+ FKR++  AS  NQ  S +++     T K     S V+SPNG        TT   K S +KS +     P+SS +
Subjt:  MAVQTFGKAPMFDD---DDEDDVPIVFKRSS--ASRQNQLDSEAKQRLNKLTGK---QGSDVSSPNGQSSNAQKRTTSLPKASPLKSEIGRQKAPNSSIQ

Query:  APLAKSQLSDSMDSRPKSLANAAVKKENDIHPAWESSDSEDDKPLSCRLKGNSN-LPSKQLTPTVPKNKVKKSSGD-------------SDDEIPLSSKF
        A  AKS L + M   P ++ + +  +++      E  DSEDD+PLS  L GN     S+Q++   P+   KK++GD             SDDE P+SS F
Subjt:  APLAKSQLSDSMDSRPKSLANAAVKKENDIHPAWESSDSEDDKPLSCRLKGNSN-LPSKQLTPTVPKNKVKKSSGD-------------SDDEIPLSSKF

Query:  QMKSASGASGGKQHGFDEKNPLVSKVHQNGSTSRDKLQKPAIVYGKRPLPNADSHSSPQLSIKKPKLSDSSTPSSVKIVSLKEKQEV-------------
        + K  SG SGG Q   DEK PLV K+HQNGST ++++    ++ GKRPL    + S+ Q S+KK K+  S++P+SVK+     K+E+             
Subjt:  QMKSASGASGGKQHGFDEKNPLVSKVHQNGSTSRDKLQKPAIVYGKRPLPNADSHSSPQLSIKKPKLSDSSTPSSVKIVSLKEKQEV-------------

Query:  ------------DDDDDDIPISQRMKKMSASVNKQSSSKQTVSKVASSSIKK-------------TFKKFEKPVKKSKYGKSTKLLPSAGDGQKKWTTLV
                    DDDDDD+PIS+R K  S++ N  S+  + V   ++SS  K               K  +K  K SKY  S+K  PS+GDGQKKWTTLV
Subjt:  ------------DDDDDDIPISQRMKKMSASVNKQSSSKQTVSKVASSSIKK-------------TFKKFEKPVKKSKYGKSTKLLPSAGDGQKKWTTLV

Query:  HNGVIFPPPYQTHRVKMLYKGKPVGLTPEQEEVATMFAVMKDTDYMLKPKFKENFWNDWRKILGKNHAIQNLDDCDFTPIYDWYQIEKEKKKQMTSEEKK
        HNGVIFPPPY+ H +K+LYKGKPV LT EQEEVATMFAVM++TDY  KP+F+ENFWNDWR++LGK H IQ LDDCDFTPIY+W+  EKEKKKQM++EEKK
Subjt:  HNGVIFPPPYQTHRVKMLYKGKPVGLTPEQEEVATMFAVMKDTDYMLKPKFKENFWNDWRKILGKNHAIQNLDDCDFTPIYDWYQIEKEKKKQMTSEEKK

Query:  ALKEEKLKQEEKYMWAILDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRIRPSDITINIGKDAPIPECPIPGERWKEVRHDNTVTWLAFWNDPINPKE
        ALKEEK+KQEEKYMWA++DGVKEK+GNFRVEPPGLFRGRGEHPKMGKLKKRI P +IT+NIGK APIPECPI GERWKEV+HDNTVTWLAFW DPINPKE
Subjt:  ALKEEKLKQEEKYMWAILDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRIRPSDITINIGKDAPIPECPIPGERWKEVRHDNTVTWLAFWNDPINPKE

Query:  FKYVFLAASSSLKGQSDKEKYEKARMLKDYIKNIRNAYTKDFTSKDPTRRQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVKAVPPNLLEFNF
        FKYVFL A SSLKG SDKEKYEKAR L D+I NIR  YTK+FT+KD   RQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKV NV+ +PPN ++F+F
Subjt:  FKYVFLAASSSLKGQSDKEKYEKARMLKDYIKNIRNAYTKDFTSKDPTRRQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVKAVPPNLLEFNF

Query:  LGKDSIKYENTVEVELPVFKAITQFQSGKSGSDDLFDKLDTSKLNAHLKDLMPGLTAKVFRTYNASITLDDMLNRGTKEGEVAEKIATYQHANKEVAIIC
        LGKDSI+Y NTVEVE  V+KAI QFQ+GKS +DDLFD+LDTSKLNAHLK+L+PGLTAKVFRTYNASITLD+ML++ TK+G+V +KI  YQ ANKEVAIIC
Subjt:  LGKDSIKYENTVEVELPVFKAITQFQSGKSGSDDLFDKLDTSKLNAHLKDLMPGLTAKVFRTYNASITLDDMLNRGTKEGEVAEKIATYQHANKEVAIIC

Query:  NHQRTVSKSHGAQMSRLNEKISELRDILKELKIDLDRAKKGKPPLKDADGKQKRNLAPEALEKKISQTNVKIEKIERDMQTKEDLKTVALGTSKINYLDP
        NHQRTVSK+HGAQ+ +L  +I EL+++LKELK +LDRAKKGKPPL+ +DGK+ R+L P A EKKI+Q + KIEK+ERDM TKEDLKTVALGTSKINYLDP
Subjt:  NHQRTVSKSHGAQMSRLNEKISELRDILKELKIDLDRAKKGKPPLKDADGKQKRNLAPEALEKKISQTNVKIEKIERDMQTKEDLKTVALGTSKINYLDP

Query:  RITVAWCKRHEVPIEKIFNKSLLAKFAWAMDVDPDFRF
        RITVAWCKRHEVPIEKIF KSLL KFAWAMDV+P++RF
Subjt:  RITVAWCKRHEVPIEKIFNKSLLAKFAWAMDVDPDFRF

P93119 DNA topoisomerase 1

2.3e-239

60.91

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Query:  SSDSEDDKPLSCR-----LKGNSN---LPSKQLTP---TVPKNKVKKSSGDSDDEIPLSSKFQMKSASGASGGKQHGFDEKNPLVSKVHQNGSTSRDKLQ
        S DS+DDKPLS +     L GNS+   + S    P   T PK ++ K     +DE+ LSS+ Q+   +GAS  +    DE  PL S           +L+
Subjt:  SSDSEDDKPLSCR-----LKGNSN---LPSKQLTP---TVPKNKVKKSSGDSDDEIPLSSKFQMKSASGASGGKQHGFDEKNPLVSKVHQNGSTSRDKLQ

Query:  KPAIVYGKRPLPNADSHSSPQLSIKKPKLSDSSTPSSVKIVSLKEKQEVDDDDDDIPISQRMKKMSASVNKQSSSKQTVSKVASSSIKKTFKKFEKPVKK
         P+    KRPL     +S P  S KK KLS+ S P++ K+ + ++++   DDD    IS R KK +   +K S  K+      S+S+ K        V  
Subjt:  KPAIVYGKRPLPNADSHSSPQLSIKKPKLSDSSTPSSVKIVSLKEKQEVDDDDDDIPISQRMKKMSASVNKQSSSKQTVSKVASSSIKKTFKKFEKPVKK

Query:  SKYGKSTKLLPSAGDGQKKWTTLVHNGVIFPPPYQTHRVKMLYKGKPVGLTPEQEEVATMFAVMKDTDYMLKPKFKENFWNDWRKILGKNHAIQNLDDCD
        SK  K   +L    +GQ     LVHNGVIFPP Y+ H VKMLY+  PV LTPEQEEVATMFAVM +T+YM KPKF+ENF +DWRKILG+ H IQNL+DCD
Subjt:  SKYGKSTKLLPSAGDGQKKWTTLVHNGVIFPPPYQTHRVKMLYKGKPVGLTPEQEEVATMFAVMKDTDYMLKPKFKENFWNDWRKILGKNHAIQNLDDCD

Query:  FTPIYDWYQIEKEKKKQMTSEEKKALKEEKLK-QEEKYMWAILDGV-KEKVGNFRVEPPGLFRGRGEHPKMGKLKKRIRPS-DITINIGKDAPIPECPIP
        FTPIY+W+Q EKEKKKQM+++EKKA+KE K + ++EKYMWA++DG+ +EKVGNFRV    + +      K  ++KK +    DITINIGKDAPIPE PIP
Subjt:  FTPIYDWYQIEKEKKKQMTSEEKKALKEEKLK-QEEKYMWAILDGV-KEKVGNFRVEPPGLFRGRGEHPKMGKLKKRIRPS-DITINIGKDAPIPECPIP

Query:  GERWKEVRHDNTVTWLAFWNDPINPKEFKYVFLAASSSLKGQSDKEKYEKARMLKDYIKNIR-NAYTKDFTSKDPTRRQIAVATYLIDKLALRAGNEKDD
        GERWKE+RHDNTVTWLAFWNDPINPKEFKYVFLAASSSLKG+  +EKYEK+R LKDYI+ IR  AYTKDF SKD  +RQIAVATYLIDKLALRAGNEKDD
Subjt:  GERWKEVRHDNTVTWLAFWNDPINPKEFKYVFLAASSSLKGQSDKEKYEKARMLKDYIKNIR-NAYTKDFTSKDPTRRQIAVATYLIDKLALRAGNEKDD

Query:  DEADTVGCCTLKVENVKAVPPNLLEFNFLGKDSIKYENTVEVELPVFKAITQFQSGKSGSDDLFDKLDTSKLNAHLKDLMPGLTAKVFRTYNASITLDDM
        DEADTVGCCTLKVENV+   PN+L+F+FLGKDSI+Y+N VEVE  VF AI QF+SGK G DDLFD+LDTSKLNAHLK+LMPGLTAKVFRTYNASITLD+M
Subjt:  DEADTVGCCTLKVENVKAVPPNLLEFNFLGKDSIKYENTVEVELPVFKAITQFQSGKSGSDDLFDKLDTSKLNAHLKDLMPGLTAKVFRTYNASITLDDM

Query:  -----LNRGTKEGEVAEKIATYQHANKEVAIICNHQRTVSKSHGAQMSRLNEKISELRDILKELKIDLDRAKKGKPPLKDADGKQKRNLAPE--------
             L+R TK G+VAEK+  YQHANKEVAIICNHQRTVSKSH AQM RLNEKI EL+ +LKEL+ DL R  KGKPPLK++DGK KRNL  +        
Subjt:  -----LNRGTKEGEVAEKIATYQHANKEVAIICNHQRTVSKSHGAQMSRLNEKISELRDILKELKIDLDRAKKGKPPLKDADGKQKRNLAPE--------

Query:  --------------ALEKKISQTNVKIEKIERDMQTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFAWAMDVDPDFRF
                      ++ KKI+QTN KIEK+ERD +TKEDLKTVALGTSKINYLDPRITVAWCKRH+VPIEKIFNKSLLAKFAWAMDV   FRF
Subjt:  --------------ALEKKISQTNVKIEKIERDMQTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFAWAMDVDPDFRF

Q54RC3 DNA topoisomerase 1

1.8e-146

39.5

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Query:  KRTTSLPKASPL----------KSEIGRQKAPNSSIQAPLAKSQL---SDSMDSRPKSLANAAVKKENDIHPAWESSDSEDDKPLSCRLKGNSNLPSKQL
        K+ T  PK +P+          K  I ++K  +SS  +  + S     SDS DS   S ++ +   ++D+ P  +      +KP     K + N P    
Subjt:  KRTTSLPKASPL----------KSEIGRQKAPNSSIQAPLAKSQL---SDSMDSRPKSLANAAVKKENDIHPAWESSDSEDDKPLSCRLKGNSNLPSKQL

Query:  TPTV--------PKNKVKKSSGDSDDEIPLSSKFQMKSASGASGGKQHGFDEKNPLVSKVHQNGSTSRDKLQKPAIVYGKRPLPNADSHSSPQLSIKK--
        T T         P  KVK     SDD    SS      +S  S       +E+ P            +   +KPA V  +  +    + ++ +  +KK  
Subjt:  TPTV--------PKNKVKKSSGDSDDEIPLSSKFQMKSASGASGGKQHGFDEKNPLVSKVHQNGSTSRDKLQKPAIVYGKRPLPNADSHSSPQLSIKK--

Query:  --PKLSDSSTPSSVKIVSLKEKQEVDDDDDDIPISQRMKKMSASVNKQSSSKQTVSKVASSSIKKTFKKFEKPVKKSKYG--KSTKLLPSAGDGQKKWTT
           K + ++T   VK      K+E DDD +D                    ++T +K  +++ K+  K+ E+  ++ + G  K         DG  KWTT
Subjt:  --PKLSDSSTPSSVKIVSLKEKQEVDDDDDDIPISQRMKKMSASVNKQSSSKQTVSKVASSSIKKTFKKFEKPVKKSKYG--KSTKLLPSAGDGQKKWTT

Query:  LVHNGVIFPPPYQTHRVKMLYKGKPVGLTPEQEEVATMFAVMKDTDYMLKPKFKENFWNDWRKIL--GKNHAIQNLDDCDFTPIYDWYQIEKEKKKQMTS
        L+HNG +FPP Y  H +K +Y GK V LTP+QEEVAT +A   +TD++ K  FK+NF+ +++ +L   +   ++ +D CDF+ I+   + +KE++K  + 
Subjt:  LVHNGVIFPPPYQTHRVKMLYKGKPVGLTPEQEEVATMFAVMKDTDYMLKPKFKENFWNDWRKIL--GKNHAIQNLDDCDFTPIYDWYQIEKEKKKQMTS

Query:  EEKKALKEEKLKQEEKYMWAILDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRIRPSDITINIGKDAPIPECPIPGERWKEVRHDNTVTWLAFWNDPI
        EEK A   EK K +EK+ +A +DG KEKVGN+ +EPPGLF GRG+HPK G LK+RI PSD+T+NIG+   IP  PIPGE+WKE+ H+NTVTWLAFW + +
Subjt:  EEKKALKEEKLKQEEKYMWAILDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRIRPSDITINIGKDAPIPECPIPGERWKEVRHDNTVTWLAFWNDPI

Query:  NPKEFKYVFLAASSSLKGQSDKEKYEKARMLKDYIKNIRNAYTKDFTSKDPTRRQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVKAVPPNLL
        N   FKYV+LA SS +KGQ+D++K+E AR LK+ I +IR  Y K F  +   +RQ+AVA YLID LALR GNEK +D+ADTVGCC+L+VE++K    N +
Subjt:  NPKEFKYVFLAASSSLKGQSDKEKYEKARMLKDYIKNIRNAYTKDFTSKDPTRRQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVKAVPPNLL

Query:  EFNFLGKDSIKYENTVEVELPVFKAITQFQSGKSGSDDLFDKLDTSKLNAHLKDLMPGLTAKVFRTYNASITLDDMLNR-GTKEGE-VAEKIATYQHANK
          +FLGKDS++Y NTV++    +K +  F  GK  +D LFD L  ++LN HLK  M GL+AKVFRTYNASITL   L++  TKE + + EKI  Y   N+
Subjt:  EFNFLGKDSIKYENTVEVELPVFKAITQFQSGKSGSDDLFDKLDTSKLNAHLKDLMPGLTAKVFRTYNASITLDDMLNR-GTKEGE-VAEKIATYQHANK

Query:  EVAIICNHQRTVSKSHGAQMSRLNEKISELRDILKELKIDLDRAKKGKPP-------------------------LKDADGK--------------QKRN
        EVAI+CNHQ+   K+    MS+++EKI ELRD+      DL R K GK P                          KD D +              +K  
Subjt:  EVAIICNHQRTVSKSHGAQMSRLNEKISELRDILKELKIDLDRAKKGKPP-------------------------LKDADGK--------------QKRN

Query:  LAPEA---LEKKISQTNVKIEKIERDMQTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFAWAMDVDPDFRF
          P+A   +++KI++   +I+K E     K++LKTVALGTSKINYLDPRITVAWCK+++VP++KIF KSL  KF W+ DV  D+ F
Subjt:  LAPEA---LEKKISQTNVKIEKIERDMQTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFAWAMDVDPDFRF

Q9FJ79 DNA topoisomerase 1 beta

2.2e-293

60.92

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Query:  FDDDDEDDVPIVFKRSS-----ASRQNQLDSEAKQRL---NKLTGKQGSDVSSPNGQSSNAQKRTTSLPKASPLKSEIGRQKAPNSSIQAPLAKSQLSDS
        ++D+DEDD+P+VFKR+S      +R + +++  +       K +    S ++SPN +S+++  R++ +  A P  S + R     S++++PL   +   +
Subjt:  FDDDDEDDVPIVFKRSS-----ASRQNQLDSEAKQRL---NKLTGKQGSDVSSPNGQSSNAQKRTTSLPKASPLKSEIGRQKAPNSSIQAPLAKSQLSDS

Query:  MDSRPKSLANAAVKKENDIHPAWESSDSEDDKPLSCRLKGNSNLPSKQLTPT--------VPKNKVKKSSGDS-------DDEIPLSSKFQMKSASGASG
         +      A +  K +++        DSEDDKPLS RLK +S   +KQ + +        V K+ ++             D+  P+SS  Q K++ G S 
Subjt:  MDSRPKSLANAAVKKENDIHPAWESSDSEDDKPLSCRLKGNSNLPSKQLTPT--------VPKNKVKKSSGDS-------DDEIPLSSKFQMKSASGASG

Query:  GKQHGFDEKNPLVSKVHQNG---STSRDKLQKPAIVYGKRPLPNADSHSSPQLSIKKPKLSDSSTPSSVKIVS-----------------------LKEK
         K    ++K PLV+ + +NG    T     Q PA    KRPL      SS Q S+K+PKLS+ + P  V+  S                          K
Subjt:  GKQHGFDEKNPLVSKVHQNG---STSRDKLQKPAIVYGKRPLPNADSHSSPQLSIKKPKLSDSSTPSSVKIVS-----------------------LKEK

Query:  QEVDDDDDDIPISQRMKKMSASVNKQSSSKQTVSKVASSSIKKTFKKFEKPVKKSKYGKSTKLLPSAGDGQKKWTTLVHNGVIFPPPYQTHRVKMLYKGK
        ++  D DD +PI+ RMK  S++ NK SS+K + SK+ +SS +   +K  K VK SKY KS+K LPS GDGQKKW TL HNGVIFPPPY+ H VK+L++GK
Subjt:  QEVDDDDDDIPISQRMKKMSASVNKQSSSKQTVSKVASSSIKKTFKKFEKPVKKSKYGKSTKLLPSAGDGQKKWTTLVHNGVIFPPPYQTHRVKMLYKGK

Query:  PVGLTPEQEEVATMFAVMKDTDYMLKPKFKENFWNDWRKILGKNHAIQNLDDCDFTPIYDWYQIEKEKKKQMTSEEKKALKEEKLKQEEKYMWAILDGVK
        PV LTPEQEEVATMFAVM++T+Y  KPKF+ENFWNDWRK+LGKNH I++LDDCDFTPIY+WY  EKE KKQMT+EEK+ +KEEKLKQEEKYMWA+LDGV+
Subjt:  PVGLTPEQEEVATMFAVMKDTDYMLKPKFKENFWNDWRKILGKNHAIQNLDDCDFTPIYDWYQIEKEKKKQMTSEEKKALKEEKLKQEEKYMWAILDGVK

Query:  EKVGNFRVEPPGLFRGRGEHPKMGKLKKRIRPSDITINIGKDAPIPECPIPGERWKEVRHDNTVTWLAFWNDPINPKEFKYVFLAASSSLKGQSDKEKYE
        E++GNFRVEPPGLFRGRGEHPKMGKLKKRIRP DITINIGK+APIPECPIPGERWKEV+HDNTVTWLAFW+DPINPKEFKYVFLAASSSLKGQSDKEKYE
Subjt:  EKVGNFRVEPPGLFRGRGEHPKMGKLKKRIRPSDITINIGKDAPIPECPIPGERWKEVRHDNTVTWLAFWNDPINPKEFKYVFLAASSSLKGQSDKEKYE

Query:  KARMLKDYIKNIRNAYTKDFTSKDPTRRQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVKAVPPNLLEFNFLGKDSIKYENTVEVELPVFKAI
        KAR L ++I +IR AYTKDF +KD T+RQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKV NV+ +PPN L+F+FLGKDSI+Y NTVEVE  V+KAI
Subjt:  KARMLKDYIKNIRNAYTKDFTSKDPTRRQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVKAVPPNLLEFNFLGKDSIKYENTVEVELPVFKAI

Query:  TQFQSGKSGSDDLFDKLDTSKLNAHLKDLMPGLTAKVFRTYNASITLDDMLNRGTKEGEVAEKIATYQHANKEVAIICNHQRTVSKSHGAQMSRLNEKIS
         QFQ+GKS +DDLFD+LDTSKLN HLK+LM GLTAKVFRTYNASITLD ML++ T++G+V EK+  YQ ANKEVAIICNHQRTVSKSHGAQ+ +L  KI 
Subjt:  TQFQSGKSGSDDLFDKLDTSKLNAHLKDLMPGLTAKVFRTYNASITLDDMLNRGTKEGEVAEKIATYQHANKEVAIICNHQRTVSKSHGAQMSRLNEKIS

Query:  ELRDILKELKIDLDRAKKGKPPLKDADGKQKRNLAPEALEKKISQTNVKIEKIERDMQTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSL
        ELR+ +KEL IDLDRAKKG+ PL  +DGK+KRNL PEALEKKI QT  KIEK+ERDMQTKED+KTVALGTSKINY+DPRITVAWCKRH+VPIEKIFNKSL
Subjt:  ELRDILKELKIDLDRAKKGKPPLKDADGKQKRNLAPEALEKKISQTNVKIEKIERDMQTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSL

Query:  LAKFAWAMDVDPDFRF
        LAKFAWAMDVDP+FRF
Subjt:  LAKFAWAMDVDPDFRF

Arabidopsis top hits

e value

%identity

Alignment

AT4G26701.1 DNA binding;DNA topoisomerase type Is

3.7e-30

88.41

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Query:  VKIEKIERDMQTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFAWAMDVDPDFRF
        +KIEK+ERDMQTKEDLKTVALGTSKINY+DPRITVAWCKRHE PIEKIFNKSLL KFAWAMDV+P F F
Subjt:  VKIEKIERDMQTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFAWAMDVDPDFRF

AT5G55300.1 DNA topoisomerase I alpha

7.9e-299

60.66

Show/hide

Query:  MAVQTFGKAPMFDD---DDEDDVPIVFKRSS--ASRQNQLDSEAKQRLNKLTGK---QGSDVSSPNGQSSNAQKRTTSLPKASPLKSEIGRQKAPNSSIQ
        M  +T  K P+ D+   D +DD P+ FKR++  AS  NQ  S +++     T K     S V+SPNG        TT   K S +KS +     P+SS +
Subjt:  MAVQTFGKAPMFDD---DDEDDVPIVFKRSS--ASRQNQLDSEAKQRLNKLTGK---QGSDVSSPNGQSSNAQKRTTSLPKASPLKSEIGRQKAPNSSIQ

Query:  APLAKSQLSDSMDSRPKSLANAAVKKENDIHPAWESSDSEDDKPLSCRLKGNSN-LPSKQLTPTVPKNKVKKSSGD-------------SDDEIPLSSKF
        A  AKS L + M   P ++ + +  +++      E  DSEDD+PLS  L GN     S+Q++   P+   KK++GD             SDDE P+SS F
Subjt:  APLAKSQLSDSMDSRPKSLANAAVKKENDIHPAWESSDSEDDKPLSCRLKGNSN-LPSKQLTPTVPKNKVKKSSGD-------------SDDEIPLSSKF

Query:  QMKSASGASGGKQHGFDEKNPLVSKVHQNGSTSRDKLQKPAIVYGKRPLPNADSHSSPQLSIKKPKLSDSSTPSSVKIVSLKEKQEV-------------
        + K  SG SGG Q   DEK PLV K+HQNGST ++++    ++ GKRPL    + S+ Q S+KK K+  S++P+SVK+     K+E+             
Subjt:  QMKSASGASGGKQHGFDEKNPLVSKVHQNGSTSRDKLQKPAIVYGKRPLPNADSHSSPQLSIKKPKLSDSSTPSSVKIVSLKEKQEV-------------

Query:  ------------DDDDDDIPISQRMKKMSASVNKQSSSKQTVSKVASSSIKK-------------TFKKFEKPVKKSKYGKSTKLLPSAGDGQKKWTTLV
                    DDDDDD+PIS+R K  S++ N  S+  + V   ++SS  K               K  +K  K SKY  S+K  PS+GDGQKKWTTLV
Subjt:  ------------DDDDDDIPISQRMKKMSASVNKQSSSKQTVSKVASSSIKK-------------TFKKFEKPVKKSKYGKSTKLLPSAGDGQKKWTTLV

Query:  HNGVIFPPPYQTHRVKMLYKGKPVGLTPEQEEVATMFAVMKDTDYMLKPKFKENFWNDWRKILGKNHAIQNLDDCDFTPIYDWYQIEKEKKKQMTSEEKK
        HNGVIFPPPY+ H +K+LYKGKPV LT EQEEVATMFAVM++TDY  KP+F+ENFWNDWR++LGK H IQ LDDCDFTPIY+W+  EKEKKKQM++EEKK
Subjt:  HNGVIFPPPYQTHRVKMLYKGKPVGLTPEQEEVATMFAVMKDTDYMLKPKFKENFWNDWRKILGKNHAIQNLDDCDFTPIYDWYQIEKEKKKQMTSEEKK

Query:  ALKEEKLKQEEKYMWAILDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRIRPSDITINIGKDAPIPECPIPGERWKEVRHDNTVTWLAFWNDPINPKE
        ALKEEK+KQEEKYMWA++DGVKEK+GNFRVEPPGLFRGRGEHPKMGKLKKRI P +IT+NIGK APIPECPI GERWKEV+HDNTVTWLAFW DPINPKE
Subjt:  ALKEEKLKQEEKYMWAILDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRIRPSDITINIGKDAPIPECPIPGERWKEVRHDNTVTWLAFWNDPINPKE

Query:  FKYVFLAASSSLKGQSDKEKYEKARMLKDYIKNIRNAYTKDFTSKDPTRRQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVKAVPPNLLEFNF
        FKYVFL A SSLKG SDKEKYEKAR L D+I NIR  YTK+FT+KD   RQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKV NV+ +PPN ++F+F
Subjt:  FKYVFLAASSSLKGQSDKEKYEKARMLKDYIKNIRNAYTKDFTSKDPTRRQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVKAVPPNLLEFNF

Query:  LGKDSIKYENTVEVELPVFKAITQFQSGKSGSDDLFDKLDTSKLNAHLKDLMPGLTAKVFRTYNASITLDDMLNRGTKEGEVAEKIATYQHANKEVAIIC
        LGKDSI+Y NTVEVE  V+KAI QFQ+GKS +DDLFD+LDTSKLNAHLK+L+PGLTAKVFRTYNASITLD+ML++ TK+G+V +KI  YQ ANKEVAIIC
Subjt:  LGKDSIKYENTVEVELPVFKAITQFQSGKSGSDDLFDKLDTSKLNAHLKDLMPGLTAKVFRTYNASITLDDMLNRGTKEGEVAEKIATYQHANKEVAIIC

Query:  NHQRTVSKSHGAQMSRLNEKISELRDILKELKIDLDRAKKGKPPLKDADGKQKRNLAPEALEKKISQTNVKIEKIERDMQTKEDLKTVALGTSKINYLDP
        NHQRTVSK+HGAQ+ +L  +I EL+++LKELK +LDRAKKGKPPL+ +DGK+ R+L P A EKKI+Q + KIEK+ERDM TKEDLKTVALGTSKINYLDP
Subjt:  NHQRTVSKSHGAQMSRLNEKISELRDILKELKIDLDRAKKGKPPLKDADGKQKRNLAPEALEKKISQTNVKIEKIERDMQTKEDLKTVALGTSKINYLDP

Query:  RITVAWCKRHEVPIEKIFNKSLLAKFAWAMDVDPDFRF
        RITVAWCKRHEVPIEKIF KSLL KFAWAMDV+P++RF
Subjt:  RITVAWCKRHEVPIEKIFNKSLLAKFAWAMDVDPDFRF

AT5G55300.2 DNA topoisomerase I alpha

2.5e-297

60.64

Show/hide

Query:  MAVQTFGKAPMFDD---DDEDDVPIVFKRSS--ASRQNQLDSEAKQRLNKLTGK---QGSDVSSPNGQSSNAQKRTTSLPKASPLKSEIGRQKAPNSSIQ
        M  +T  K P+ D+   D +DD P+ FKR++  AS  NQ  S +++     T K     S V+SPNG        TT   K S +KS +     P+SS +
Subjt:  MAVQTFGKAPMFDD---DDEDDVPIVFKRSS--ASRQNQLDSEAKQRLNKLTGK---QGSDVSSPNGQSSNAQKRTTSLPKASPLKSEIGRQKAPNSSIQ

Query:  APLAKSQLSDSMDSRPKSLANAAVKKENDIHPAWESSDSEDDKPLSCRLKGNSN-LPSKQLTPTVPKNKVKKSSGD-------------SDDEIPLSSKF
        A  AKS L + M   P ++ + +  +++      E  DSEDD+PLS  L GN     S+Q++   P+   KK++GD             SDDE P+SS F
Subjt:  APLAKSQLSDSMDSRPKSLANAAVKKENDIHPAWESSDSEDDKPLSCRLKGNSN-LPSKQLTPTVPKNKVKKSSGD-------------SDDEIPLSSKF

Query:  QMKSASGASGGKQHGFDEKNPLVSKVHQNGSTSRDKLQKPAIVYGKRPLPNADSHSSPQLSIKKPKLSDSSTPSSVKIVSLKEKQEV-------------
        + K  SG SGG Q   DEK PLV K+HQNGST ++++    ++ GKRPL    + S+ Q S+KK K+  S++P+SVK+     K+E+             
Subjt:  QMKSASGASGGKQHGFDEKNPLVSKVHQNGSTSRDKLQKPAIVYGKRPLPNADSHSSPQLSIKKPKLSDSSTPSSVKIVSLKEKQEV-------------

Query:  ------------DDDDDDIPISQRMKKMSASVNKQSSSKQTVSKVASSSIKK-------------TFKKFEKPVKKSKYGKSTKLLPSAGDGQKKWTTLV
                    DDDDDD+PIS+R K  S++ N  S+  + V   ++SS  K               K  +K  K SKY  S+K  PS+GDGQKKWTTLV
Subjt:  ------------DDDDDDIPISQRMKKMSASVNKQSSSKQTVSKVASSSIKK-------------TFKKFEKPVKKSKYGKSTKLLPSAGDGQKKWTTLV

Query:  HNGVIFPPPYQTHRVKMLYKGKPVGLTPEQEEVATMFAVMKDTDYMLKPKFKENFWNDWRKILGKNHAIQNLDDCDFTPIYDWYQIEKEKKKQMTSEEKK
        HNGVIFPPPY+ H +K+LYKGKPV LT EQEEVATMFAVM++TDY  KP+F+ENFWNDWR++LGK H IQ LDDCDFTPIY+W+  EKEKKKQM++EEKK
Subjt:  HNGVIFPPPYQTHRVKMLYKGKPVGLTPEQEEVATMFAVMKDTDYMLKPKFKENFWNDWRKILGKNHAIQNLDDCDFTPIYDWYQIEKEKKKQMTSEEKK

Query:  ALKEEKLKQEEKYMWAILDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRIRPSDITINIGKDAPIPECPIPGERWKEVRHDNTVTWLAFWNDPINPKE
        ALKEEK+KQEEKYMWA++DGVKEK+GNFRVEPPGLFRGRGEHPKMGKLKKRI P +IT+NIGK APIPECPI GERWKEV+HDNTVTWLAFW DPINPKE
Subjt:  ALKEEKLKQEEKYMWAILDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRIRPSDITINIGKDAPIPECPIPGERWKEVRHDNTVTWLAFWNDPINPKE

Query:  FKYVFLAASSSLKGQSDKEKYEKARMLKDYIKNIRNAYTKDFTSKDPTRRQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVKAVPPNLLEFNF
        FKYVFL A SSLKG SDKEKYEKAR L D+I NIR  YTK+FT+KD   RQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKV NV+ +PPN ++F+F
Subjt:  FKYVFLAASSSLKGQSDKEKYEKARMLKDYIKNIRNAYTKDFTSKDPTRRQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVKAVPPNLLEFNF

Query:  LGKDSIKYENTVEVELPVFKAITQFQSGKSGSDDLFDKLDTSKLNAHLKDLMPGLTAKVFRTYNASITLDDMLNRGTKEGEVAEKIATYQHANKEVAIIC
        LGKDSI+Y NTVEVE  V+KAI QFQ+GKS +DDLFD+LDTSKLNAHLK+L+PGLTAKVFRTYNASITLD+ML++ TK+G+V +KI  YQ ANKEVAIIC
Subjt:  LGKDSIKYENTVEVELPVFKAITQFQSGKSGSDDLFDKLDTSKLNAHLKDLMPGLTAKVFRTYNASITLDDMLNRGTKEGEVAEKIATYQHANKEVAIIC

Query:  NHQRTVSKSHGAQMSRLNEKISELRDILKELKIDLDRAKKGKPPLKDADGKQKRNLAPEALEKKISQTNVKIEKIERDMQTKEDLKTVALGTSKINYLDP
        NHQRTVSK+HGAQ+ +L  +I EL+++LKELK +LDRAKKGKPPL+ +DGK+ R+L P A EKKI+Q + KIEK+ERDM TKEDLKTVALGTSKINYLDP
Subjt:  NHQRTVSKSHGAQMSRLNEKISELRDILKELKIDLDRAKKGKPPLKDADGKQKRNLAPEALEKKISQTNVKIEKIERDMQTKEDLKTVALGTSKINYLDP

Query:  RITVAWCKRHEVPIEKIFNKSLLAKFAWAMDVDPD
        RITVAWCKRHEVPIEKIF KSLL KFAWAMDV+P+
Subjt:  RITVAWCKRHEVPIEKIFNKSLLAKFAWAMDVDPD

AT5G55300.3 DNA topoisomerase I alpha

3.0e-112

35.89

Show/hide

Query:  MAVQTFGKAPMFDD---DDEDDVPIVFKRSS--ASRQNQLDSEAKQRLNKLTGK---QGSDVSSPNGQSSNAQKRTTSLPKASPLKSEIGRQKAPNSSIQ
        M  +T  K P+ D+   D +DD P+ FKR++  AS  NQ  S +++     T K     S V+SPNG        TT   K S +KS +     P+SS +
Subjt:  MAVQTFGKAPMFDD---DDEDDVPIVFKRSS--ASRQNQLDSEAKQRLNKLTGK---QGSDVSSPNGQSSNAQKRTTSLPKASPLKSEIGRQKAPNSSIQ

Query:  APLAKSQLSDSMDSRPKSLANAAVKKENDIHPAWESSDSEDDKPLSCRLKGNSN-LPSKQLTPTVPKNKVKKSSGD-------------SDDEIPLSSKF
        A  AKS L + M   P ++ + +  +++      E  DSEDD+PLS  L GN     S+Q++   P+   KK++GD             SDDE P+SS F
Subjt:  APLAKSQLSDSMDSRPKSLANAAVKKENDIHPAWESSDSEDDKPLSCRLKGNSN-LPSKQLTPTVPKNKVKKSSGD-------------SDDEIPLSSKF

Query:  QMKSASGASGGKQHGFDEKNPLVSKVHQNGSTSRDKLQKPAIVYGKRPLPNADSHSSPQLSIKKPKLSDSSTPSSVKIVSLKEKQEVDDDDDDIPISQRM
        + K  SG SGG Q   DEK PLV K+HQNGST ++++    ++ GKRPL    + S+ Q S+KK K+  S++P+SVK+     K+E+DD           
Subjt:  QMKSASGASGGKQHGFDEKNPLVSKVHQNGSTSRDKLQKPAIVYGKRPLPNADSHSSPQLSIKKPKLSDSSTPSSVKIVSLKEKQEVDDDDDDIPISQRM

Query:  KKMSASVNKQSSSKQTVSKVASSSIKKTFKKFEKPVKKSKYGKSTKLLPSAGDGQKKWTTLVHNGVIFPPPYQTHRVKMLYKGKPVGLTPEQEEVATMFA
                                                                                         KG+                
Subjt:  KKMSASVNKQSSSKQTVSKVASSSIKKTFKKFEKPVKKSKYGKSTKLLPSAGDGQKKWTTLVHNGVIFPPPYQTHRVKMLYKGKPVGLTPEQEEVATMFA

Query:  VMKDTDYMLKPKFKENFWNDWRKILGKNHAIQNLDDCDFTPIYDWYQIEKEKKKQMTSEEKKALKEEKLKQEEKYMWAILDGVKEKVGNFRVEPPGLFRG
               ++ PK                                       K KQ+++ E                                        
Subjt:  VMKDTDYMLKPKFKENFWNDWRKILGKNHAIQNLDDCDFTPIYDWYQIEKEKKKQMTSEEKKALKEEKLKQEEKYMWAILDGVKEKVGNFRVEPPGLFRG

Query:  RGEHPKMGKLKKRIRPSDITINIGKDAPIPECPIPGERWKEVRHDNTVTWLAFWNDPINPKEFKYVFLAASSSLKGQSDKEKYEKARMLKDYIKNIRNAY
                                                                                                            
Subjt:  RGEHPKMGKLKKRIRPSDITINIGKDAPIPECPIPGERWKEVRHDNTVTWLAFWNDPINPKEFKYVFLAASSSLKGQSDKEKYEKARMLKDYIKNIRNAY

Query:  TKDFTSKDPTRRQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVKAVPPNLLEFNFLGKDSIKYENTVEVELPVFKAITQFQSGKSGSDDLFDK
          D T  D                     ++ DDDEADTVGCCTLKV NV+ +PPN ++F+FLGKDSI+Y NTVEVE  V+KAI QFQ+GKS +DDLFD+
Subjt:  TKDFTSKDPTRRQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVKAVPPNLLEFNFLGKDSIKYENTVEVELPVFKAITQFQSGKSGSDDLFDK

Query:  LDTSKLNAHLKDLMPGLTAKVFRTYNASITLDDMLNRGTKEGEVAEKIATYQHANKEVAIICNHQRTVSKSHGAQMSRLNEKISELRDILKELKIDLDRA
        LDTSKLNAHLK+L+PGLTAKVFRTYNASITLD+ML++ TK+G+V +KI  YQ ANKEVAIICNHQRTVSK+HGAQ+ +L  +I EL+++LKELK +LDRA
Subjt:  LDTSKLNAHLKDLMPGLTAKVFRTYNASITLDDMLNRGTKEGEVAEKIATYQHANKEVAIICNHQRTVSKSHGAQMSRLNEKISELRDILKELKIDLDRA

Query:  KKGKPPLKDADGKQKRNLAPEALEKKISQTNVKIEKIERDMQTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFAWAMDVDPDFRF
        KKGKPPL+ +DGK+ R+L P A EKKI+Q + KIEK+ERDM TKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIF KSLL KFAWAMDV+P++RF
Subjt:  KKGKPPLKDADGKQKRNLAPEALEKKISQTNVKIEKIERDMQTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFAWAMDVDPDFRF

AT5G55310.1 DNA topoisomerase 1 beta

1.5e-294

60.92

Show/hide

Query:  FDDDDEDDVPIVFKRSS-----ASRQNQLDSEAKQRL---NKLTGKQGSDVSSPNGQSSNAQKRTTSLPKASPLKSEIGRQKAPNSSIQAPLAKSQLSDS
        ++D+DEDD+P+VFKR+S      +R + +++  +       K +    S ++SPN +S+++  R++ +  A P  S + R     S++++PL   +   +
Subjt:  FDDDDEDDVPIVFKRSS-----ASRQNQLDSEAKQRL---NKLTGKQGSDVSSPNGQSSNAQKRTTSLPKASPLKSEIGRQKAPNSSIQAPLAKSQLSDS

Query:  MDSRPKSLANAAVKKENDIHPAWESSDSEDDKPLSCRLKGNSNLPSKQLTPT--------VPKNKVKKSSGDS-------DDEIPLSSKFQMKSASGASG
         +      A +  K +++        DSEDDKPLS RLK +S   +KQ + +        V K+ ++             D+  P+SS  Q K++ G S 
Subjt:  MDSRPKSLANAAVKKENDIHPAWESSDSEDDKPLSCRLKGNSNLPSKQLTPT--------VPKNKVKKSSGDS-------DDEIPLSSKFQMKSASGASG

Query:  GKQHGFDEKNPLVSKVHQNG---STSRDKLQKPAIVYGKRPLPNADSHSSPQLSIKKPKLSDSSTPSSVKIVS-----------------------LKEK
         K    ++K PLV+ + +NG    T     Q PA    KRPL      SS Q S+K+PKLS+ + P  V+  S                          K
Subjt:  GKQHGFDEKNPLVSKVHQNG---STSRDKLQKPAIVYGKRPLPNADSHSSPQLSIKKPKLSDSSTPSSVKIVS-----------------------LKEK

Query:  QEVDDDDDDIPISQRMKKMSASVNKQSSSKQTVSKVASSSIKKTFKKFEKPVKKSKYGKSTKLLPSAGDGQKKWTTLVHNGVIFPPPYQTHRVKMLYKGK
        ++  D DD +PI+ RMK  S++ NK SS+K + SK+ +SS +   +K  K VK SKY KS+K LPS GDGQKKW TL HNGVIFPPPY+ H VK+L++GK
Subjt:  QEVDDDDDDIPISQRMKKMSASVNKQSSSKQTVSKVASSSIKKTFKKFEKPVKKSKYGKSTKLLPSAGDGQKKWTTLVHNGVIFPPPYQTHRVKMLYKGK

Query:  PVGLTPEQEEVATMFAVMKDTDYMLKPKFKENFWNDWRKILGKNHAIQNLDDCDFTPIYDWYQIEKEKKKQMTSEEKKALKEEKLKQEEKYMWAILDGVK
        PV LTPEQEEVATMFAVM++T+Y  KPKF+ENFWNDWRK+LGKNH I++LDDCDFTPIY+WY  EKE KKQMT+EEK+ +KEEKLKQEEKYMWA+LDGV+
Subjt:  PVGLTPEQEEVATMFAVMKDTDYMLKPKFKENFWNDWRKILGKNHAIQNLDDCDFTPIYDWYQIEKEKKKQMTSEEKKALKEEKLKQEEKYMWAILDGVK

Query:  EKVGNFRVEPPGLFRGRGEHPKMGKLKKRIRPSDITINIGKDAPIPECPIPGERWKEVRHDNTVTWLAFWNDPINPKEFKYVFLAASSSLKGQSDKEKYE
        E++GNFRVEPPGLFRGRGEHPKMGKLKKRIRP DITINIGK+APIPECPIPGERWKEV+HDNTVTWLAFW+DPINPKEFKYVFLAASSSLKGQSDKEKYE
Subjt:  EKVGNFRVEPPGLFRGRGEHPKMGKLKKRIRPSDITINIGKDAPIPECPIPGERWKEVRHDNTVTWLAFWNDPINPKEFKYVFLAASSSLKGQSDKEKYE

Query:  KARMLKDYIKNIRNAYTKDFTSKDPTRRQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVKAVPPNLLEFNFLGKDSIKYENTVEVELPVFKAI
        KAR L ++I +IR AYTKDF +KD T+RQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKV NV+ +PPN L+F+FLGKDSI+Y NTVEVE  V+KAI
Subjt:  KARMLKDYIKNIRNAYTKDFTSKDPTRRQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVKAVPPNLLEFNFLGKDSIKYENTVEVELPVFKAI

Query:  TQFQSGKSGSDDLFDKLDTSKLNAHLKDLMPGLTAKVFRTYNASITLDDMLNRGTKEGEVAEKIATYQHANKEVAIICNHQRTVSKSHGAQMSRLNEKIS
         QFQ+GKS +DDLFD+LDTSKLN HLK+LM GLTAKVFRTYNASITLD ML++ T++G+V EK+  YQ ANKEVAIICNHQRTVSKSHGAQ+ +L  KI 
Subjt:  TQFQSGKSGSDDLFDKLDTSKLNAHLKDLMPGLTAKVFRTYNASITLDDMLNRGTKEGEVAEKIATYQHANKEVAIICNHQRTVSKSHGAQMSRLNEKIS

Query:  ELRDILKELKIDLDRAKKGKPPLKDADGKQKRNLAPEALEKKISQTNVKIEKIERDMQTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSL
        ELR+ +KEL IDLDRAKKG+ PL  +DGK+KRNL PEALEKKI QT  KIEK+ERDMQTKED+KTVALGTSKINY+DPRITVAWCKRH+VPIEKIFNKSL
Subjt:  ELRDILKELKIDLDRAKKGKPPLKDADGKQKRNLAPEALEKKISQTNVKIEKIERDMQTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSL

Query:  LAKFAWAMDVDPDFRF
        LAKFAWAMDVDP+FRF
Subjt:  LAKFAWAMDVDPDFRF

Sequences

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CDS sequence

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ATGGCTGTTCAAACCTTTGGAAAAGCACCAATGTTCGACGACGACGATGAGGACGACGTCCCAATAGTTTTCAAAAGAAGTAGTGCATCCAGGCAAAACCAGTTAGATTC
GGAAGCCAAGCAGAGGTTGAATAAGTTAACGGGGAAGCAGGGTTCTGATGTAAGTTCACCCAATGGTCAAAGCTCTAATGCTCAAAAAAGGACGACTTCATTGCCAAAGG
CATCGCCCTTGAAATCTGAAATAGGAAGGCAGAAAGCACCCAATTCCTCAATCCAGGCACCACTTGCTAAATCACAACTTTCAGATTCTATGGATAGCCGACCGAAAAGT
TTGGCAAATGCTGCTGTGAAAAAGGAGAATGATATACACCCTGCTTGGGAAAGTAGTGACTCTGAAGATGATAAACCATTGAGTTGTAGATTGAAAGGGAACTCCAACCT
CCCCAGTAAACAGCTTACACCAACGGTACCAAAGAATAAGGTAAAAAAATCATCAGGAGATTCTGATGATGAAATTCCTTTGTCATCAAAATTTCAAATGAAGTCTGCTT
CCGGGGCGTCTGGTGGTAAACAACATGGTTTTGATGAAAAGAATCCATTGGTTTCAAAAGTTCATCAGAATGGTTCAACCTCAAGGGATAAGCTGCAAAAGCCTGCTATT
GTTTATGGCAAGAGACCTCTTCCTAATGCAGATTCCCATTCATCTCCTCAACTTTCAATAAAAAAGCCAAAGCTTTCCGACTCATCTACTCCTTCGAGTGTTAAGATAGT
ATCATTGAAAGAAAAACAAGAAGTAGATGACGACGATGACGATATCCCTATTTCACAGAGAATGAAGAAGATGTCTGCATCTGTGAACAAGCAATCAAGTTCTAAGCAAA
CAGTATCCAAAGTTGCTTCTTCTTCAATTAAGAAAACATTCAAGAAATTTGAAAAGCCAGTCAAGAAATCTAAATATGGAAAGTCCACAAAGTTGCTGCCCAGTGCTGGT
GATGGACAGAAAAAGTGGACTACCTTGGTTCACAATGGTGTCATTTTCCCACCCCCATACCAGACTCATAGGGTGAAGATGCTTTATAAAGGGAAGCCTGTTGGTTTGAC
TCCTGAACAAGAGGAGGTTGCAACCATGTTTGCTGTGATGAAGGATACGGATTATATGCTAAAACCAAAATTCAAAGAAAATTTCTGGAATGACTGGCGGAAGATACTTG
GGAAGAACCATGCCATTCAAAATTTGGATGATTGTGATTTCACCCCAATATACGACTGGTATCAGATAGAAAAGGAGAAGAAGAAGCAGATGACTTCTGAAGAGAAGAAA
GCTTTGAAGGAGGAGAAACTGAAACAAGAGGAGAAGTACATGTGGGCTATTCTTGATGGGGTTAAGGAGAAGGTTGGGAACTTTAGAGTTGAACCACCTGGATTGTTCAG
AGGCCGTGGAGAGCATCCAAAGATGGGGAAATTGAAAAAACGCATTCGCCCCAGTGACATCACAATTAATATTGGAAAAGATGCTCCGATCCCCGAATGCCCTATACCTG
GTGAAAGATGGAAGGAAGTGAGACATGACAATACGGTTACATGGTTGGCTTTCTGGAATGACCCAATAAATCCAAAAGAATTCAAGTATGTGTTTCTGGCTGCTAGTAGT
TCATTGAAAGGCCAGAGTGACAAGGAGAAATACGAGAAAGCAAGGATGCTCAAGGACTACATAAAAAACATAAGGAATGCGTATACAAAGGATTTTACAAGCAAGGACCC
TACACGTAGGCAAATTGCAGTTGCTACTTATCTCATTGATAAACTGGCTCTCAGGGCTGGGAATGAGAAAGATGATGATGAAGCTGATACAGTTGGCTGCTGTACACTGA
AAGTAGAGAATGTCAAAGCAGTACCTCCTAATCTTTTGGAGTTCAACTTCCTCGGTAAAGATTCAATCAAGTATGAAAATACGGTTGAGGTTGAGCTCCCAGTTTTCAAA
GCAATCACACAATTTCAAAGTGGAAAAAGTGGAAGTGACGATCTTTTTGACAAGCTGGATACGAGTAAATTAAATGCTCATCTGAAGGATCTCATGCCTGGTTTAACTGC
AAAAGTGTTTCGTACATATAATGCTTCGATCACACTTGATGACATGTTGAACAGAGGAACTAAAGAAGGAGAAGTTGCAGAAAAGATCGCTACTTACCAGCATGCAAACA
AGGAGGTTGCAATTATTTGTAATCACCAGCGGACTGTTTCAAAATCTCACGGGGCTCAAATGTCGAGATTGAATGAGAAGATCTCTGAGCTCAGGGACATTCTGAAAGAG
CTGAAAATTGATTTGGATAGAGCAAAGAAAGGGAAGCCCCCTTTAAAAGATGCTGATGGAAAGCAAAAGAGGAATTTGGCACCTGAAGCATTAGAGAAGAAGATATCTCA
AACAAATGTAAAGATTGAGAAGATAGAGCGAGATATGCAGACTAAAGAGGATTTGAAAACCGTGGCGTTAGGCACATCAAAGATCAACTACCTTGATCCTCGAATCACCG
TTGCATGGTGCAAGCGTCATGAAGTCCCCATCGAAAAGATATTCAACAAGTCTCTTCTTGCAAAGTTCGCATGGGCAATGGACGTCGATCCCGACTTCAGATTCTGA

mRNA sequence

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GAAAGGGAAAGGAAAAGAAACGAAAGTGCATAATAAACAGAACCACAAATGTGTTGGGTGGGAAGAGGAGGTTCATCCAAGGCTCCTTCCTTCGGTTGGTGTTTTTAATT
TTCCTAAACCCTAAACAAAACAAACCCAAACCCAAAACCAAACCAAACCAAAATTAAACCATCTCCTTCTCCTTTTTTCTGATTCACGACAACCATTTTTAGGTTTCCCC
TTCGCCCTCCTCTCTCTCTGTCTCTCTCTCCTCCATTAACAACCCGACTGAGCTTCATCCAAAGCTCACCCTCAGACTGATGTTACAACAGTTTCCGGCCATCTGTACAT
AGCTGCGCTATGGCTGTTCAAACCTTTGGAAAAGCACCAATGTTCGACGACGACGATGAGGACGACGTCCCAATAGTTTTCAAAAGAAGTAGTGCATCCAGGCAAAACCA
GTTAGATTCGGAAGCCAAGCAGAGGTTGAATAAGTTAACGGGGAAGCAGGGTTCTGATGTAAGTTCACCCAATGGTCAAAGCTCTAATGCTCAAAAAAGGACGACTTCAT
TGCCAAAGGCATCGCCCTTGAAATCTGAAATAGGAAGGCAGAAAGCACCCAATTCCTCAATCCAGGCACCACTTGCTAAATCACAACTTTCAGATTCTATGGATAGCCGA
CCGAAAAGTTTGGCAAATGCTGCTGTGAAAAAGGAGAATGATATACACCCTGCTTGGGAAAGTAGTGACTCTGAAGATGATAAACCATTGAGTTGTAGATTGAAAGGGAA
CTCCAACCTCCCCAGTAAACAGCTTACACCAACGGTACCAAAGAATAAGGTAAAAAAATCATCAGGAGATTCTGATGATGAAATTCCTTTGTCATCAAAATTTCAAATGA
AGTCTGCTTCCGGGGCGTCTGGTGGTAAACAACATGGTTTTGATGAAAAGAATCCATTGGTTTCAAAAGTTCATCAGAATGGTTCAACCTCAAGGGATAAGCTGCAAAAG
CCTGCTATTGTTTATGGCAAGAGACCTCTTCCTAATGCAGATTCCCATTCATCTCCTCAACTTTCAATAAAAAAGCCAAAGCTTTCCGACTCATCTACTCCTTCGAGTGT
TAAGATAGTATCATTGAAAGAAAAACAAGAAGTAGATGACGACGATGACGATATCCCTATTTCACAGAGAATGAAGAAGATGTCTGCATCTGTGAACAAGCAATCAAGTT
CTAAGCAAACAGTATCCAAAGTTGCTTCTTCTTCAATTAAGAAAACATTCAAGAAATTTGAAAAGCCAGTCAAGAAATCTAAATATGGAAAGTCCACAAAGTTGCTGCCC
AGTGCTGGTGATGGACAGAAAAAGTGGACTACCTTGGTTCACAATGGTGTCATTTTCCCACCCCCATACCAGACTCATAGGGTGAAGATGCTTTATAAAGGGAAGCCTGT
TGGTTTGACTCCTGAACAAGAGGAGGTTGCAACCATGTTTGCTGTGATGAAGGATACGGATTATATGCTAAAACCAAAATTCAAAGAAAATTTCTGGAATGACTGGCGGA
AGATACTTGGGAAGAACCATGCCATTCAAAATTTGGATGATTGTGATTTCACCCCAATATACGACTGGTATCAGATAGAAAAGGAGAAGAAGAAGCAGATGACTTCTGAA
GAGAAGAAAGCTTTGAAGGAGGAGAAACTGAAACAAGAGGAGAAGTACATGTGGGCTATTCTTGATGGGGTTAAGGAGAAGGTTGGGAACTTTAGAGTTGAACCACCTGG
ATTGTTCAGAGGCCGTGGAGAGCATCCAAAGATGGGGAAATTGAAAAAACGCATTCGCCCCAGTGACATCACAATTAATATTGGAAAAGATGCTCCGATCCCCGAATGCC
CTATACCTGGTGAAAGATGGAAGGAAGTGAGACATGACAATACGGTTACATGGTTGGCTTTCTGGAATGACCCAATAAATCCAAAAGAATTCAAGTATGTGTTTCTGGCT
GCTAGTAGTTCATTGAAAGGCCAGAGTGACAAGGAGAAATACGAGAAAGCAAGGATGCTCAAGGACTACATAAAAAACATAAGGAATGCGTATACAAAGGATTTTACAAG
CAAGGACCCTACACGTAGGCAAATTGCAGTTGCTACTTATCTCATTGATAAACTGGCTCTCAGGGCTGGGAATGAGAAAGATGATGATGAAGCTGATACAGTTGGCTGCT
GTACACTGAAAGTAGAGAATGTCAAAGCAGTACCTCCTAATCTTTTGGAGTTCAACTTCCTCGGTAAAGATTCAATCAAGTATGAAAATACGGTTGAGGTTGAGCTCCCA
GTTTTCAAAGCAATCACACAATTTCAAAGTGGAAAAAGTGGAAGTGACGATCTTTTTGACAAGCTGGATACGAGTAAATTAAATGCTCATCTGAAGGATCTCATGCCTGG
TTTAACTGCAAAAGTGTTTCGTACATATAATGCTTCGATCACACTTGATGACATGTTGAACAGAGGAACTAAAGAAGGAGAAGTTGCAGAAAAGATCGCTACTTACCAGC
ATGCAAACAAGGAGGTTGCAATTATTTGTAATCACCAGCGGACTGTTTCAAAATCTCACGGGGCTCAAATGTCGAGATTGAATGAGAAGATCTCTGAGCTCAGGGACATT
CTGAAAGAGCTGAAAATTGATTTGGATAGAGCAAAGAAAGGGAAGCCCCCTTTAAAAGATGCTGATGGAAAGCAAAAGAGGAATTTGGCACCTGAAGCATTAGAGAAGAA
GATATCTCAAACAAATGTAAAGATTGAGAAGATAGAGCGAGATATGCAGACTAAAGAGGATTTGAAAACCGTGGCGTTAGGCACATCAAAGATCAACTACCTTGATCCTC
GAATCACCGTTGCATGGTGCAAGCGTCATGAAGTCCCCATCGAAAAGATATTCAACAAGTCTCTTCTTGCAAAGTTCGCATGGGCAATGGACGTCGATCCCGACTTCAGA
TTCTGATTGTTGTGTTAAATTGCGGTGATATAAAACGCATCTTTCACCACGGCGGAACCTCGAAGGAAAAAAGAAAGCGATGGAGTAGGAAAAATTGAAGTGTCCATTTT
GCATTACATTCAATTTTTCTTTTTAATCCTTTAGATGCAGAGAGTAAAGTCCCATGATGTATGGTTATCTAATCTTCTAATTATACTGGGTTAATGGCTCATTTCTGACA
CTCCCCCATATCCCCCCCTCCTCACAAGCTGTGCTATGGAAACATTTGATTATTCAAAGCTTTCAAAACAGCCTTATACTAATTGTTGAACATTTTAACACACCTTTATA
AATTTGATTATACCTGCCTTTCTT

Protein sequence

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MAVQTFGKAPMFDDDDEDDVPIVFKRSSASRQNQLDSEAKQRLNKLTGKQGSDVSSPNGQSSNAQKRTTSLPKASPLKSEIGRQKAPNSSIQAPLAKSQLSDSMDSRPKS
LANAAVKKENDIHPAWESSDSEDDKPLSCRLKGNSNLPSKQLTPTVPKNKVKKSSGDSDDEIPLSSKFQMKSASGASGGKQHGFDEKNPLVSKVHQNGSTSRDKLQKPAI
VYGKRPLPNADSHSSPQLSIKKPKLSDSSTPSSVKIVSLKEKQEVDDDDDDIPISQRMKKMSASVNKQSSSKQTVSKVASSSIKKTFKKFEKPVKKSKYGKSTKLLPSAG
DGQKKWTTLVHNGVIFPPPYQTHRVKMLYKGKPVGLTPEQEEVATMFAVMKDTDYMLKPKFKENFWNDWRKILGKNHAIQNLDDCDFTPIYDWYQIEKEKKKQMTSEEKK
ALKEEKLKQEEKYMWAILDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRIRPSDITINIGKDAPIPECPIPGERWKEVRHDNTVTWLAFWNDPINPKEFKYVFLAASS
SLKGQSDKEKYEKARMLKDYIKNIRNAYTKDFTSKDPTRRQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVKAVPPNLLEFNFLGKDSIKYENTVEVELPVFK
AITQFQSGKSGSDDLFDKLDTSKLNAHLKDLMPGLTAKVFRTYNASITLDDMLNRGTKEGEVAEKIATYQHANKEVAIICNHQRTVSKSHGAQMSRLNEKISELRDILKE
LKIDLDRAKKGKPPLKDADGKQKRNLAPEALEKKISQTNVKIEKIERDMQTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFAWAMDVDPDFRF

Sed0024196 (gene) of Chayote v1 genome