CuGenDBv2

Gene ID	Sed0024297
Organism	Sechium edule (Chayote v1)
Description	DNA topoisomerase 2
Genome location	LG05:26065546..26072918
RNA-Seq Expression	Sed0024297
Synteny	Sed0024297
Gene Ontology terms	GO:0006265 - DNA topological change (biological process) GO:0043231 - intracellular membrane-bounded organelle (cellular component) GO:0003677 - DNA binding (molecular function) GO:0046872 - metal ion binding (molecular function) GO:0005524 - ATP binding (molecular function) GO:0003918 - DNA topoisomerase type II (ATP-hydrolyzing) activity (molecular function)
InterPro domains	IPR013506 - DNA topoisomerase, type IIA, subunit B, domain 2 IPR036890 - Histidine kinase/HSP90-like ATPase superfamily IPR034157 - DNA topoisomerase 2, TOPRIM domain IPR031660 - C-terminal associated domain of TOPRIM IPR020568 - Ribosomal protein S5 domain 2-type fold IPR018522 - DNA topoisomerase, type IIA, conserved site IPR014721 - Ribosomal protein S5 domain 2-type fold, subgroup IPR013760 - DNA topoisomerase, type IIA-like domain superfamily IPR013759 - DNA topoisomerase, type IIA, subunit B, C-terminal IPR013758 - DNA topoisomerase, type IIA, subunit A/ C-terminal, alpha-beta IPR013757 - Type IIA DNA topoisomerase subunit A, alpha-helical domain superfamily IPR006171 - TOPRIM domain IPR003594 - Histidine kinase/HSP90-like ATPase IPR002205 - DNA topoisomerase, type IIA, subunit A/C-terminal IPR001241 - DNA topoisomerase, type IIA IPR001154 - DNA topoisomerase II, eukaryotic-type

Homology

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GenBank top hits

e value

%identity

Alignment

KAG7018075.1 DNA topoisomerase 2 [Cucurbita argyrosperma subsp. argyrosperma]

0.0e+00

89.89

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Query:  MAVEKKRPLQNSNAANVDQLPAGPKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMD
        MAVEKKRPLQNSNAANVD  PAGPKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMD
Subjt:  MAVEKKRPLQNSNAANVDQLPAGPKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMD

Query:  SLKVVIDAEQNCISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDAEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFSDNMGKKSE
        SLKVVIDAEQN ISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDD EKKTTGGRNGYGAKLTNIFSTEFVIETADG+RLKKYKQVFSDNMGKKSE
Subjt:  SLKVVIDAEQNCISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDAEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFSDNMGKKSE

Query:  PIIAKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASAFSSEPPKRYHVKPNERWEIVV
        PII KCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVD YLKSA+AF +EPPKRYH++PNERWEIVV
Subjt:  PIIAKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASAFSSEPPKRYHVKPNERWEIVV

Query:  TLSEGQFQQVSFVNGIATIKGGTHVDYISNQIANYVMNAVNKKNKNANVKAHNVKNYLWVFINALIDNPAFDSQTKETLTIRQNSFGSACDLTPEFLKNV
        TLSEGQFQQVSFVNGIATIKGGTHVDYI+NQIANYVM  VNKKNKNANVKAHNVK+YLWVFINALIDNPAFDSQTKETLTIRQ+SFGSAC+LTP+FLKNV
Subjt:  TLSEGQFQQVSFVNGIATIKGGTHVDYISNQIANYVMNAVNKKNKNANVKAHNVKNYLWVFINALIDNPAFDSQTKETLTIRQNSFGSACDLTPEFLKNV

Query:  ATKSGIMDSVLSWVNFKQSKDLKKTDGTKTEKINGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASNKQIM
        ATKSGIMDSVLSWVNFKQSKDLKKTDG KTEKI+GIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREAS+KQI 
Subjt:  ATKSGIMDSVLSWVNFKQSKDLKKTDGTKTEKINGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASNKQIM

Query:  ENKEIQYIKQILGLQQGKEYNNAKALRYGHLMIMTDQDHDGSHIKGLLINFVHSFWPSLLRVPSFLVEFITPIVKATHKNGTVLSFYTMPEYESWKESLR
        ENKEIQYIKQILGLQQGKEYNNAKALRYGHLMIMTDQDHDGSHIKGLLINF+HSFWPSLLRVPSFLVEFITPIVKATH+NGTVLSFYTMPEYE+WK++LR
Subjt:  ENKEIQYIKQILGLQQGKEYNNAKALRYGHLMIMTDQDHDGSHIKGLLINFVHSFWPSLLRVPSFLVEFITPIVKATHKNGTVLSFYTMPEYESWKESLR

Query:  NNASGWSIKYYKGLGTSTSKEGREYFEQLAKHKKDFIWQDDNDGEAIELAFSKKKIEERKNWLRQFEPGTHLDQTGKLIKYSDFVNKELILFSMADLQRS
         NASGWSIKYYKGLGTSTSKEGREYFEQLAKHKKDFIWQD++DGEAIELAFSKKKIEERKNWLRQFE GTHLDQ+ KLIKYSDFVNKELILFSMADLQRS
Subjt:  NNASGWSIKYYKGLGTSTSKEGREYFEQLAKHKKDFIWQDDNDGEAIELAFSKKKIEERKNWLRQFEPGTHLDQTGKLIKYSDFVNKELILFSMADLQRS

Query:  IPSMVDGLKPGQRKILFCSFKRNFIKEAKISQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT
        IPSMVDGLKPGQRKILFCSFKRNFIKEAK+SQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLSN T
Subjt:  IPSMVDGLKPGQRKILFCSFKRNFIKEAKISQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT

Query:  RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDIIRNVRRMLNSETLLPMDPWYRGFSGTIEKTATKEGGSSYTVS
        RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSY+PNYNPRDIIRNVRRMLN E +LPMDPWYRGFSGTIEKTATKEGG+SYTVS
Subjt:  RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDIIRNVRRMLNSETLLPMDPWYRGFSGTIEKTATKEGGSSYTVS

Query:  GIIEEVSDTTLRVIELPVRKWTNDYKEFLDSVTR-TYKNDKDKDKVAKEPFIEQADHHSDDKIVSIDVHLTEENMILAMQEGLMKKLKLTTTISTSNMHL
        GIIEEVSDTTLR+ ELPVR+WTNDYK+FLDSVTR + KNDKDK+K AK+PFIEQADHHSDDK VSIDVHLTEENMILAMQEGL KK KLTTT+STSNMHL
Subjt:  GIIEEVSDTTLRVIELPVRKWTNDYKEFLDSVTR-TYKNDKDKDKVAKEPFIEQADHHSDDKIVSIDVHLTEENMILAMQEGLMKKLKLTTTISTSNMHL

Query:  FDANGVIKKYDTPEQILEEFFPLRLEYYEKRKRNLLENLEMELLKLENKVRFILAVVNGEIIVSNRRRVDLFHELQAKGFTPFPKKAKSVEPEVAGASNE
        FDANGVIKKYDTPEQILEEFFPLRLE++EKRKRNLLENLE ELLKLENKVRFILAVVNGEIIVSNRRRVDLFHELQ KGFTPFPKK KSVEPEVAGASNE
Subjt:  FDANGVIKKYDTPEQILEEFFPLRLEYYEKRKRNLLENLEMELLKLENKVRFILAVVNGEIIVSNRRRVDLFHELQAKGFTPFPKKAKSVEPEVAGASNE

Query:  TDEAEESPE-VKGERVSDYEYLLALAIGNLTIEKVQELCNNRDKLKGEVEDLRKATPKSLWLCDLDSLEKELDEMDRADANAEEVRKQQRKSNNDIKPKI
        TDEAEESPE VKGERVSDYEYLLALAIG LTIEKVQELCN RDK KGEVE+LRKATPKSLWL DLD LEKELDEMDR DA A+EVRKQQR  NNDIKPKI
Subjt:  TDEAEESPE-VKGERVSDYEYLLALAIGNLTIEKVQELCNNRDKLKGEVEDLRKATPKSLWLCDLDSLEKELDEMDRADANAEEVRKQQRKSNNDIKPKI

Query:  SRNVPKAPRNNKKTSNSETVTESMD-TTSSSSTMEVASNAVVKPKGKAAAPRKAPAKK-GKGPVVNDDAKDDDEEVLELKDRLAAYKIDSSPDRSE--AM
        SRN PKAPRN+KKTSNSET+TESMD TTSSS+T EVA+N VVKPKGK AAPRKAPAKK GK  V++D   DDD+EVLELKDRLAAYK++SSP+ SE  AM
Subjt:  SRNVPKAPRNNKKTSNSETVTESMD-TTSSSSTMEVASNAVVKPKGKAAAPRKAPAKK-GKGPVVNDDAKDDDEEVLELKDRLAAYKIDSSPDRSE--AM

Query:  ETEVPQVQ-AAKKKEPTKRAPAKKKTTAKSVHISDNDTDDDNFEIKEVRPPAAKKGGGGRKTAANA------NTTKKREPAAKLGQKLITQMLSPAENTG
        ETEVP+VQ AAKKKEP+KRA AKKKTTAKS  ISD D+DD +FEIKE+ PPAAKK GGGRK AANA       TTKK+EP A+LGQKLITQML P EN+G
Subjt:  ETEVPQVQ-AAKKKEPTKRAPAKKKTTAKSVHISDNDTDDDNFEIKEVRPPAAKKGGGGRKTAANA------NTTKKREPAAKLGQKLITQMLSPAENTG

Query:  ISPEKKVRKIRASPFNKKSGSILGRTGIEEEEEEEEEEDGNEGKIMGSGSSETTEESAGVAP-ARGRSQRGNRTQVRYVISDSESEPEAVDSDFDDKDAD
        ISPEKKVRKIR SPFNKKSGS+LGR     EEEEE EE GNEGK+MGS SSETT+E     P ARGRSQR NRTQVRYV+SDS+SEP   DSDFD+ +A+
Subjt:  ISPEKKVRKIRASPFNKKSGSILGRTGIEEEEEEEEEEDGNEGKIMGSGSSETTEESAGVAP-ARGRSQRGNRTQVRYVISDSESEPEAVDSDFDDKDAD

Query:  FDED
         DED
Subjt:  FDED

XP_022152632.1 DNA topoisomerase 2 isoform X2 [Momordica charantia]

0.0e+00

89.74

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Query:  MAVEKKRPLQNSNAANVDQLPAGPKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMD
        MAVEKKRPLQNS  ANVD  PAGPKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMD
Subjt:  MAVEKKRPLQNSNAANVDQLPAGPKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMD

Query:  SLKVVIDAEQNCISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDAEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFSDNMGKKSE
        S+KVVID EQNCISVFNNGDGVPVE+HQEEKVYVPELIFGHLLTSSNYDD  KKTTGGRNGYGAKLTNIFSTEFVIETADGKR KKYKQVF DNMGKKSE
Subjt:  SLKVVIDAEQNCISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDAEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFSDNMGKKSE

Query:  PIIAKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASAFSSEPPKRYHVKPNERWEIVV
        P+I KCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLD+AGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSAS F +EPPKRYH+KPNERWEIVV
Subjt:  PIIAKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASAFSSEPPKRYHVKPNERWEIVV

Query:  TLSEGQFQQVSFVNGIATIKGGTHVDYISNQIANYVMNAVNKKNKNANVKAHNVKNYLWVFINALIDNPAFDSQTKETLTIRQNSFGSACDLTPEFLKNV
        TLSEGQFQQVSFVN IATIKGGTHVDYI+NQIANYVMN VNKKNKNANVKAHNVK+YLWVFINALIDNPAFDSQTKETLTIRQ+SFGS C+LTPEFLKNV
Subjt:  TLSEGQFQQVSFVNGIATIKGGTHVDYISNQIANYVMNAVNKKNKNANVKAHNVKNYLWVFINALIDNPAFDSQTKETLTIRQNSFGSACDLTPEFLKNV

Query:  ATKSGIMDSVLSWVNFKQSKDLKKTDGTKTEKINGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASNKQIM
        A+KSGIMDSVLSWVNFKQSKDLKKTDG KTEKI+GIEKLEDANCAGG+NSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREAS+KQI 
Subjt:  ATKSGIMDSVLSWVNFKQSKDLKKTDGTKTEKINGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASNKQIM

Query:  ENKEIQYIKQILGLQQGKEYNNAKALRYGHLMIMTDQDHDGSHIKGLLINFVHSFWPSLLRVPSFLVEFITPIVKATHKNGTVLSFYTMPEYESWKESLR
        ENKEIQYIKQILGLQQGKEYNN K LRYGHLMIMTDQDHDGSHIKGLLINF+HSFWPSLLRVPSFLVEFITPIVKATH+NGTVLSFYTMPEYESWKESLR
Subjt:  ENKEIQYIKQILGLQQGKEYNNAKALRYGHLMIMTDQDHDGSHIKGLLINFVHSFWPSLLRVPSFLVEFITPIVKATHKNGTVLSFYTMPEYESWKESLR

Query:  NNASGWSIKYYKGLGTSTSKEGREYFEQLAKHKKDFIWQDDNDGEAIELAFSKKKIEERKNWLRQFEPGTHLDQTGKLIKYSDFVNKELILFSMADLQRS
         NASGWSIKYYKGLGTSTSKEGREYFEQL KHKKDF+WQDD+DGEAIELAFSKKKIEERKNWLR FEPGTHLDQT KLIKYSDFVNKELILFSMADLQRS
Subjt:  NNASGWSIKYYKGLGTSTSKEGREYFEQLAKHKKDFIWQDDNDGEAIELAFSKKKIEERKNWLRQFEPGTHLDQTGKLIKYSDFVNKELILFSMADLQRS

Query:  IPSMVDGLKPGQRKILFCSFKRNFIKEAKISQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT
        IPS+VDGLKPGQRKILFCSFKRNFIKEAK+SQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT
Subjt:  IPSMVDGLKPGQRKILFCSFKRNFIKEAKISQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT

Query:  RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDIIRNVRRMLNSETLLPMDPWYRGFSGTIEKTATKEGGSSYTVS
        RFLFP+DDD+LLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDII NV+R+L+ ET++PMDPWY+GFSG IEKTATKEGG SYTVS
Subjt:  RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDIIRNVRRMLNSETLLPMDPWYRGFSGTIEKTATKEGGSSYTVS

Query:  GIIEEVSDTTLRVIELPVRKWTNDYKEFLDSVTRTYKNDKDKDKVAKEPFIEQADHHSDDKIVSIDVHLTEENMILAMQEGLMKKLKLTTTISTSNMHLF
        GIIEEVSDTTLR+ ELPVR+WTNDYKEFLDSVTR      DK+K AK+PFIEQADHHSDDK VSIDVHLTEENMILA+QEGL KK KLTTT+STSNMHLF
Subjt:  GIIEEVSDTTLRVIELPVRKWTNDYKEFLDSVTRTYKNDKDKDKVAKEPFIEQADHHSDDKIVSIDVHLTEENMILAMQEGLMKKLKLTTTISTSNMHLF

Query:  DANGVIKKYDTPEQILEEFFPLRLEYYEKRKRNLLENLEMELLKLENKVRFILAVVNGEIIVSNRRRVDLFHELQAKGFTPFPKKAKSVEPEVAGASNET
        D+NGVIKKYDTPEQILEEFFPLRLEYYEKRK NLLENLE ELL+LENKVRFILAVVNGEI+VSNRRRVDLFHELQAKGFTPFPKK KSVEPEVAGASNET
Subjt:  DANGVIKKYDTPEQILEEFFPLRLEYYEKRKRNLLENLEMELLKLENKVRFILAVVNGEIIVSNRRRVDLFHELQAKGFTPFPKKAKSVEPEVAGASNET

Query:  DEAEESPEVKGERVSDYEYLLALAIGNLTIEKVQELCNNRDKLKGEVEDLRKATPKSLWLCDLDSLEKELDEMDRADANAEEVRKQQR-KSNNDIKPKIS
        DEAEESPE KGERVSDY YLLALAIG LTIEKVQELCN+RD+LKGEVEDLRKATPKSLWL DLD+LEKELDEMDR DA AEEVRKQQR K+NND+KPKIS
Subjt:  DEAEESPEVKGERVSDYEYLLALAIGNLTIEKVQELCNNRDKLKGEVEDLRKATPKSLWLCDLDSLEKELDEMDRADANAEEVRKQQR-KSNNDIKPKIS

Query:  RN-VPKAPRNNKKTSNSETVTESMDTTSSSSTMEVASNAVVKPKGKAAAPRKAPAKKGKGPVVNDDAKDDDEEVLELKDRLAAYKIDSSPDRSEAMETEV
        RN  PKAPRN+KKT NSET+ ESMDTTSSS+TMEVASNAVVKPKGK AAPRKAPAKKGK  VVN +  DDD+EVLELKDRLAAYKIDSSPDRSEAMETEV
Subjt:  RN-VPKAPRNNKKTSNSETVTESMDTTSSSSTMEVASNAVVKPKGKAAAPRKAPAKKGKGPVVNDDAKDDDEEVLELKDRLAAYKIDSSPDRSEAMETEV

Query:  PQV-QAAKKKEPTKRAPAKKKTTAKSVHISDN-DTDDDNFEIKEVRPPAAKKGGGGRKTAANANTT------KKREPAA-KLGQKLITQMLSPAENTGIS
        PQV  AAKKKEP+KRAPAKKKTTAKS  ISDN D+DDD+FEIKEV PPAAKKGGG  + AANA TT      KKRE AA KLGQKLITQML P +NTGIS
Subjt:  PQV-QAAKKKEPTKRAPAKKKTTAKSVHISDN-DTDDDNFEIKEVRPPAAKKGGGGRKTAANANTT------KKREPAA-KLGQKLITQMLSPAENTGIS

Query:  PEKKVRKIRASPFNKKSGSILGRTGIEEEEEEEEEEDGNEGKIMGSGSSETTEESAGVAPARGRSQRGNRTQVRYVISDSESEPEAVDSDFDDKDADFDE
        PEKKVRK+RASPFNKKSGSILGR G  EEEEEE EE+GNEGKIMGS SSET EESAG  PARGRSQR NRTQV+YVISDS+S+P     + DDKD DFD+
Subjt:  PEKKVRKIRASPFNKKSGSILGRTGIEEEEEEEEEEDGNEGKIMGSGSSETTEESAGVAPARGRSQRGNRTQVRYVISDSESEPEAVDSDFDDKDADFDE

Query:  D
        +
Subjt:  D

XP_022935015.1 DNA topoisomerase 2 isoform X1 [Cucurbita moschata]

0.0e+00

90.07

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Query:  MAVEKKRPLQNSNAANVDQLPAGPKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMD
        MAVEKKRPLQNSNAANVD  PAGPKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMD
Subjt:  MAVEKKRPLQNSNAANVDQLPAGPKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMD

Query:  SLKVVIDAEQNCISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDAEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFSDNMGKKSE
        SLKVVIDAEQN ISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDD EKKTTGGRNGYGAKLTNIFSTEFVIETADG+RLKKYKQVFSDNMGKKSE
Subjt:  SLKVVIDAEQNCISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDAEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFSDNMGKKSE

Query:  PIIAKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASAFSSEPPKRYHVKPNERWEIVV
        PII KCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVD YLKSA+AF +EPPKRYH++PNERWEIVV
Subjt:  PIIAKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASAFSSEPPKRYHVKPNERWEIVV

Query:  TLSEGQFQQVSFVNGIATIKGGTHVDYISNQIANYVMNAVNKKNKNANVKAHNVKNYLWVFINALIDNPAFDSQTKETLTIRQNSFGSACDLTPEFLKNV
        TLSEGQFQQVSFVNGIATIKGGTHVDYI+NQIANYVM  VNKKNKNANVKAHNVK+YLWVFINALIDNPAFDSQTKETLTIRQ+SFGSAC+LTP+FLKNV
Subjt:  TLSEGQFQQVSFVNGIATIKGGTHVDYISNQIANYVMNAVNKKNKNANVKAHNVKNYLWVFINALIDNPAFDSQTKETLTIRQNSFGSACDLTPEFLKNV

Query:  ATKSGIMDSVLSWVNFKQSKDLKKTDGTKTEKINGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASNKQIM
        ATKSGIMDSVLSWVNFKQSKDLKKTDG KTEKI+GIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREAS+KQI 
Subjt:  ATKSGIMDSVLSWVNFKQSKDLKKTDGTKTEKINGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASNKQIM

Query:  ENKEIQYIKQILGLQQGKEYNNAKALRYGHLMIMTDQDHDGSHIKGLLINFVHSFWPSLLRVPSFLVEFITPIVKATHKNGTVLSFYTMPEYESWKESLR
        ENKEIQYIKQILGLQQGKEYNNAKALRYGHLMIMTDQDHDGSHIKGLLINF+HSFWPSLLRVPSFLVEFITPIVKATH+NGTVLSFYTMPEYE+WK++LR
Subjt:  ENKEIQYIKQILGLQQGKEYNNAKALRYGHLMIMTDQDHDGSHIKGLLINFVHSFWPSLLRVPSFLVEFITPIVKATHKNGTVLSFYTMPEYESWKESLR

Query:  NNASGWSIKYYKGLGTSTSKEGREYFEQLAKHKKDFIWQDDNDGEAIELAFSKKKIEERKNWLRQFEPGTHLDQTGKLIKYSDFVNKELILFSMADLQRS
         NASGWSIKYYKGLGTSTSKEGREYFEQLAKHKKDFIWQD++DGEAIELAFSKKKIEERKNWLRQFE GTHLDQ+ KLIKYSDFVNKELILFSMADLQRS
Subjt:  NNASGWSIKYYKGLGTSTSKEGREYFEQLAKHKKDFIWQDDNDGEAIELAFSKKKIEERKNWLRQFEPGTHLDQTGKLIKYSDFVNKELILFSMADLQRS

Query:  IPSMVDGLKPGQRKILFCSFKRNFIKEAKISQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT
        IPSMVDGLKPGQRKILFCSFKRNFIKEAK+SQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLSN T
Subjt:  IPSMVDGLKPGQRKILFCSFKRNFIKEAKISQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT

Query:  RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDIIRNVRRMLNSETLLPMDPWYRGFSGTIEKTATKEGGSSYTVS
        RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSY+PNYNPRDIIRNVRRMLN E +LPMDPWYRGFSGTIEKTATKEGG+SYTVS
Subjt:  RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDIIRNVRRMLNSETLLPMDPWYRGFSGTIEKTATKEGGSSYTVS

Query:  GIIEEVSDTTLRVIELPVRKWTNDYKEFLDSVTR-TYKNDKDKDKVAKEPFIEQADHHSDDKIVSIDVHLTEENMILAMQEGLMKKLKLTTTISTSNMHL
        GIIEEVSDTTLR+ ELPVR+WTNDYK+FLDSVTR + KNDKDK+K AK+PFIEQADHHSDDK VSIDVHLTEENMILAMQEGL KK KLTTT+STSNMHL
Subjt:  GIIEEVSDTTLRVIELPVRKWTNDYKEFLDSVTR-TYKNDKDKDKVAKEPFIEQADHHSDDKIVSIDVHLTEENMILAMQEGLMKKLKLTTTISTSNMHL

Query:  FDANGVIKKYDTPEQILEEFFPLRLEYYEKRKRNLLENLEMELLKLENKVRFILAVVNGEIIVSNRRRVDLFHELQAKGFTPFPKKAKSVEPEVAGASNE
        FDANGVIKKYDTPEQILEEFFPLRLE++EKRKRNLLENLE ELLKLENKVRFILAVVNGEIIVSNRRRVDLFHELQ KGFTPFPKK KSVEPEVAGASNE
Subjt:  FDANGVIKKYDTPEQILEEFFPLRLEYYEKRKRNLLENLEMELLKLENKVRFILAVVNGEIIVSNRRRVDLFHELQAKGFTPFPKKAKSVEPEVAGASNE

Query:  TDEAEESPE-VKGERVSDYEYLLALAIGNLTIEKVQELCNNRDKLKGEVEDLRKATPKSLWLCDLDSLEKELDEMDRADANAEEVRKQQRKSNNDIKPKI
        TDEAEESPE VKGERVSDYEYLLALAIG LTIEKVQELCN RDK KGEVE+LRKATPKSLWL DLD LEKELDEMDR DA A+EVRKQQR  NNDIKPKI
Subjt:  TDEAEESPE-VKGERVSDYEYLLALAIGNLTIEKVQELCNNRDKLKGEVEDLRKATPKSLWLCDLDSLEKELDEMDRADANAEEVRKQQRKSNNDIKPKI

Query:  SRNVPKAPRNNKKTSNSETVTESMD-TTSSSSTMEVASNAVVKPKGKAAAPRKAPAKK-GKGPVVNDDAKDDDEEVLELKDRLAAYKIDSSPDRSE--AM
        SRN PKAPRN+KKTSNSET+TESMD TTSSS+T EVA+N VVKPKGK AAPRKAPAKK GK  V++D   DDD+EVLELKDRLAAYK++SSP+ SE  AM
Subjt:  SRNVPKAPRNNKKTSNSETVTESMD-TTSSSSTMEVASNAVVKPKGKAAAPRKAPAKK-GKGPVVNDDAKDDDEEVLELKDRLAAYKIDSSPDRSE--AM

Query:  ETEVPQVQ-AAKKKEPTKRAPAKKKTTAKSVHISDNDTDDDNFEIKEVRPPAAKKGGGGRKTAANA---NTTKKREPAAKLGQKLITQMLSPAENTGISP
        ETEVP+VQ AAKKKEP+KRA AKKKTTAKS  ISD D+DD +FEIKE+ PPAAKK GGGRK AANA    TTKK+EP A+LGQKLITQML P EN+GISP
Subjt:  ETEVPQVQ-AAKKKEPTKRAPAKKKTTAKSVHISDNDTDDDNFEIKEVRPPAAKKGGGGRKTAANA---NTTKKREPAAKLGQKLITQMLSPAENTGISP

Query:  EKKVRKIRASPFNKKSGSILGRTGIEEEEEEEEEEDGNEGKIMGSGSSETTEESAGVAP-ARGRSQRGNRTQVRYVISDSESEPEAVDSDFDDKDADFDE
        EKKVRKIR SPFNKKSGS+LGR     EEEEE EE GNEGK+MGS SSETT+E     P ARGRSQR NRTQVRYV+SDS+SEP   DSDFD+ +A+ DE
Subjt:  EKKVRKIRASPFNKKSGSILGRTGIEEEEEEEEEEDGNEGKIMGSGSSETTEESAGVAP-ARGRSQRGNRTQVRYVISDSESEPEAVDSDFDDKDADFDE

Query:  D
        D
Subjt:  D

XP_022935016.1 DNA topoisomerase 2 isoform X2 [Cucurbita moschata]

0.0e+00

90.13

Show/hide

Query:  MAVEKKRPLQNSNAANVDQLPAGPKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMD
        MAVEKKRPLQNSNAANVD  PAGPKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMD
Subjt:  MAVEKKRPLQNSNAANVDQLPAGPKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMD

Query:  SLKVVIDAEQNCISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDAEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFSDNMGKKSE
        SLKVVIDAEQN ISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDD EKKTTGGRNGYGAKLTNIFSTEFVIETADG+RLKKYKQVFSDNMGKKSE
Subjt:  SLKVVIDAEQNCISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDAEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFSDNMGKKSE

Query:  PIIAKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASAFSSEPPKRYHVKPNERWEIVV
        PII KCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVD YLKSA+AF +EPPKRYH++PNERWEIVV
Subjt:  PIIAKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASAFSSEPPKRYHVKPNERWEIVV

Query:  TLSEGQFQQVSFVNGIATIKGGTHVDYISNQIANYVMNAVNKKNKNANVKAHNVKNYLWVFINALIDNPAFDSQTKETLTIRQNSFGSACDLTPEFLKNV
        TLSEGQFQQVSFVNGIATIKGGTHVDYI+NQIANYVM  VNKKNKNANVKAHNVK+YLWVFINALIDNPAFDSQTKETLTIRQ+SFGSAC+LTP+FLKNV
Subjt:  TLSEGQFQQVSFVNGIATIKGGTHVDYISNQIANYVMNAVNKKNKNANVKAHNVKNYLWVFINALIDNPAFDSQTKETLTIRQNSFGSACDLTPEFLKNV

Query:  ATKSGIMDSVLSWVNFKQSKDLKKTDGTKTEKINGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASNKQIM
        ATKSGIMDSVLSWVNFKQSKDLKKTDG KTEKI+GIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREAS+KQI 
Subjt:  ATKSGIMDSVLSWVNFKQSKDLKKTDGTKTEKINGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASNKQIM

Query:  ENKEIQYIKQILGLQQGKEYNNAKALRYGHLMIMTDQDHDGSHIKGLLINFVHSFWPSLLRVPSFLVEFITPIVKATHKNGTVLSFYTMPEYESWKESLR
        ENKEIQYIKQILGLQQGKEYNNAKALRYGHLMIMTDQDHDGSHIKGLLINF+HSFWPSLLRVPSFLVEFITPIVKATH+NGTVLSFYTMPEYE+WK++LR
Subjt:  ENKEIQYIKQILGLQQGKEYNNAKALRYGHLMIMTDQDHDGSHIKGLLINFVHSFWPSLLRVPSFLVEFITPIVKATHKNGTVLSFYTMPEYESWKESLR

Query:  NNASGWSIKYYKGLGTSTSKEGREYFEQLAKHKKDFIWQDDNDGEAIELAFSKKKIEERKNWLRQFEPGTHLDQTGKLIKYSDFVNKELILFSMADLQRS
         NASGWSIKYYKGLGTSTSKEGREYFEQLAKHKKDFIWQD++DGEAIELAFSKKKIEERKNWLRQFE GTHLDQ+ KLIKYSDFVNKELILFSMADLQRS
Subjt:  NNASGWSIKYYKGLGTSTSKEGREYFEQLAKHKKDFIWQDDNDGEAIELAFSKKKIEERKNWLRQFEPGTHLDQTGKLIKYSDFVNKELILFSMADLQRS

Query:  IPSMVDGLKPGQRKILFCSFKRNFIKEAKISQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT
        IPSMVDGLKPGQRKILFCSFKRNFIKEAK+SQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLSN T
Subjt:  IPSMVDGLKPGQRKILFCSFKRNFIKEAKISQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT

Query:  RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDIIRNVRRMLNSETLLPMDPWYRGFSGTIEKTATKEGGSSYTVS
        RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSY+PNYNPRDIIRNVRRMLN E +LPMDPWYRGFSGTIEKTATKEGG+SYTVS
Subjt:  RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDIIRNVRRMLNSETLLPMDPWYRGFSGTIEKTATKEGGSSYTVS

Query:  GIIEEVSDTTLRVIELPVRKWTNDYKEFLDSVTR-TYKNDKDKDKVAKEPFIEQADHHSDDKIVSIDVHLTEENMILAMQEGLMKKLKLTTTISTSNMHL
        GIIEEVSDTTLR+ ELPVR+WTNDYK+FLDSVTR + KNDKDK+K AK+PFIEQADHHSDDK VSIDVHLTEENMILAMQEGL KK KLTTT+STSNMHL
Subjt:  GIIEEVSDTTLRVIELPVRKWTNDYKEFLDSVTR-TYKNDKDKDKVAKEPFIEQADHHSDDKIVSIDVHLTEENMILAMQEGLMKKLKLTTTISTSNMHL

Query:  FDANGVIKKYDTPEQILEEFFPLRLEYYEKRKRNLLENLEMELLKLENKVRFILAVVNGEIIVSNRRRVDLFHELQAKGFTPFPKKAKSVEPEVAGASNE
        FDANGVIKKYDTPEQILEEFFPLRLE++EKRKRNLLENLE ELLKLENKVRFILAVVNGEIIVSNRRRVDLFHELQ KGFTPFPKK KSVEPEVAGASNE
Subjt:  FDANGVIKKYDTPEQILEEFFPLRLEYYEKRKRNLLENLEMELLKLENKVRFILAVVNGEIIVSNRRRVDLFHELQAKGFTPFPKKAKSVEPEVAGASNE

Query:  TDEAEESPE-VKGERVSDYEYLLALAIGNLTIEKVQELCNNRDKLKGEVEDLRKATPKSLWLCDLDSLEKELDEMDRADANAEEVRKQQRKSNNDIKPKI
        TDEAEESPE VKGERVSDYEYLLALAIG LTIEKVQELCN RDK KGEVE+LRKATPKSLWL DLD LEKELDEMDR DA A+EVRKQQR  NNDIKPKI
Subjt:  TDEAEESPE-VKGERVSDYEYLLALAIGNLTIEKVQELCNNRDKLKGEVEDLRKATPKSLWLCDLDSLEKELDEMDRADANAEEVRKQQRKSNNDIKPKI

Query:  SRNVPKAPRNNKKTSNSETVTESMD-TTSSSSTMEVASNAVVKPKGKAAAPRKAPAKKGKGPVVNDDAKDDDEEVLELKDRLAAYKIDSSPDRSE--AME
        SRN PKAPRN+KKTSNSET+TESMD TTSSS+T EVA+N VVKPKGK AAPRKAPAKKGK  V++D   DDD+EVLELKDRLAAYK++SSP+ SE  AME
Subjt:  SRNVPKAPRNNKKTSNSETVTESMD-TTSSSSTMEVASNAVVKPKGKAAAPRKAPAKKGKGPVVNDDAKDDDEEVLELKDRLAAYKIDSSPDRSE--AME

Query:  TEVPQVQ-AAKKKEPTKRAPAKKKTTAKSVHISDNDTDDDNFEIKEVRPPAAKKGGGGRKTAANA---NTTKKREPAAKLGQKLITQMLSPAENTGISPE
        TEVP+VQ AAKKKEP+KRA AKKKTTAKS  ISD D+DD +FEIKE+ PPAAKK GGGRK AANA    TTKK+EP A+LGQKLITQML P EN+GISPE
Subjt:  TEVPQVQ-AAKKKEPTKRAPAKKKTTAKSVHISDNDTDDDNFEIKEVRPPAAKKGGGGRKTAANA---NTTKKREPAAKLGQKLITQMLSPAENTGISPE

Query:  KKVRKIRASPFNKKSGSILGRTGIEEEEEEEEEEDGNEGKIMGSGSSETTEESAGVAP-ARGRSQRGNRTQVRYVISDSESEPEAVDSDFDDKDADFDED
        KKVRKIR SPFNKKSGS+LGR     EEEEE EE GNEGK+MGS SSETT+E     P ARGRSQR NRTQVRYV+SDS+SEP   DSDFD+ +A+ DED
Subjt:  KKVRKIRASPFNKKSGSILGRTGIEEEEEEEEEEDGNEGKIMGSGSSETTEESAGVAP-ARGRSQRGNRTQVRYVISDSESEPEAVDSDFDDKDADFDED

XP_023527823.1 DNA topoisomerase 2 isoform X3 [Cucurbita pepo subsp. pepo]

0.0e+00

89.93

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Query:  MAVEKKRPLQNSNAANVDQLPAGPKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMD
        MAVEKKRPLQNSNAANVD  P GPKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLW+YENDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMD
Subjt:  MAVEKKRPLQNSNAANVDQLPAGPKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMD

Query:  SLKVVIDAEQNCISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDAEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFSDNMGKKSE
        SLKVVIDAEQN ISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDD EKKTTGGRNGYGAKLTNIFSTEFVIETADG+RLKKYKQVFSDNMGKKSE
Subjt:  SLKVVIDAEQNCISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDAEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFSDNMGKKSE

Query:  PIIAKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASAFSSEPPKRYHVKPNERWEIVV
        PII KCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVD YLKSA+AF +EPPKRYH++PNERWEIVV
Subjt:  PIIAKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASAFSSEPPKRYHVKPNERWEIVV

Query:  TLSEGQFQQVSFVNGIATIKGGTHVDYISNQIANYVMNAVNKKNKNANVKAHNVKNYLWVFINALIDNPAFDSQTKETLTIRQNSFGSACDLTPEFLKNV
        TLSEGQFQQVSFVNGIATIKGGTHVDYI+NQIANYVM  VNKKNKNANVKAHNVK+YLWVFINALIDNPAFDSQTKETLTIRQ+SFGSAC+LTP+FLKNV
Subjt:  TLSEGQFQQVSFVNGIATIKGGTHVDYISNQIANYVMNAVNKKNKNANVKAHNVKNYLWVFINALIDNPAFDSQTKETLTIRQNSFGSACDLTPEFLKNV

Query:  ATKSGIMDSVLSWVNFKQSKDLKKTDGTKTEKINGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASNKQIM
        ATKSGIMDSVLSWVNFKQSKDLKKTDG KTEKI+GIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREAS+KQI 
Subjt:  ATKSGIMDSVLSWVNFKQSKDLKKTDGTKTEKINGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASNKQIM

Query:  ENKEIQYIKQILGLQQGKEYNNAKALRYGHLMIMTDQDHDGSHIKGLLINFVHSFWPSLLRVPSFLVEFITPIVKATHKNGTVLSFYTMPEYESWKESLR
        ENKEIQYIKQILGLQQGKEYNNAKALRYGHLMIMTDQDHDGSHIKGLLINF+HSFWPSLLRVPSFLVEFITPIVKATH+NGTVLSFYTMPEYE+WK++LR
Subjt:  ENKEIQYIKQILGLQQGKEYNNAKALRYGHLMIMTDQDHDGSHIKGLLINFVHSFWPSLLRVPSFLVEFITPIVKATHKNGTVLSFYTMPEYESWKESLR

Query:  NNASGWSIKYYKGLGTSTSKEGREYFEQLAKHKKDFIWQDDNDGEAIELAFSKKKIEERKNWLRQFEPGTHLDQTGKLIKYSDFVNKELILFSMADLQRS
         NASGWSIKYYKGLGTSTSKEGREYFEQLAKHKKDFIWQD++DGEAIELAFSKKKIEERKNWLRQFE GTHLDQ+ KLIKYSDFVNKELILFSMADLQRS
Subjt:  NNASGWSIKYYKGLGTSTSKEGREYFEQLAKHKKDFIWQDDNDGEAIELAFSKKKIEERKNWLRQFEPGTHLDQTGKLIKYSDFVNKELILFSMADLQRS

Query:  IPSMVDGLKPGQRKILFCSFKRNFIKEAKISQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT
        IPSMVDGLKPGQRKILFCSFKRNFIKEAK+SQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLSN T
Subjt:  IPSMVDGLKPGQRKILFCSFKRNFIKEAKISQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT

Query:  RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDIIRNVRRMLNSETLLPMDPWYRGFSGTIEKTATKEGGSSYTVS
        RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSY+PNYNPRDIIRNVRRMLN E +LPMDPWYRGFSGTIEKTATKEGG+SYTVS
Subjt:  RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDIIRNVRRMLNSETLLPMDPWYRGFSGTIEKTATKEGGSSYTVS

Query:  GIIEEVSDTTLRVIELPVRKWTNDYKEFLDSVTR-TYKNDKDKDKVAKEPFIEQADHHSDDKIVSIDVHLTEENMILAMQEGLMKKLKLTTTISTSNMHL
        GIIEEVSDTTLR+ ELPVR+WTNDYK+FLDSVTR + KNDKDK+K AK+PFIEQADHHSDDK VSIDVHLTEENMILAMQEGL KK KLTTT+STSNMHL
Subjt:  GIIEEVSDTTLRVIELPVRKWTNDYKEFLDSVTR-TYKNDKDKDKVAKEPFIEQADHHSDDKIVSIDVHLTEENMILAMQEGLMKKLKLTTTISTSNMHL

Query:  FDANGVIKKYDTPEQILEEFFPLRLEYYEKRKRNLLENLEMELLKLENKVRFILAVVNGEIIVSNRRRVDLFHELQAKGFTPFPKKAKSVEPEVAGASNE
        FDANGVIKKYDTPEQILEEFFPLRLE++EKRKRNLLENLE ELLKLENKVRFILAVVNGEIIVSNRRRVDLFHELQ KGFTPFPKK KSVEPEVAGASNE
Subjt:  FDANGVIKKYDTPEQILEEFFPLRLEYYEKRKRNLLENLEMELLKLENKVRFILAVVNGEIIVSNRRRVDLFHELQAKGFTPFPKKAKSVEPEVAGASNE

Query:  TDEAEESPE-VKGERVSDYEYLLALAIGNLTIEKVQELCNNRDKLKGEVEDLRKATPKSLWLCDLDSLEKELDEMDRADANAEEVRKQQRKSNNDIKPKI
        TDEAEESPE VKGERVSDYEYLLALAIG LTIEKVQELCN RDK KGEVE+LRKATPKSLWL DLD LEKELDEMDR DA A+EVRKQQR  NND+KPKI
Subjt:  TDEAEESPE-VKGERVSDYEYLLALAIGNLTIEKVQELCNNRDKLKGEVEDLRKATPKSLWLCDLDSLEKELDEMDRADANAEEVRKQQRKSNNDIKPKI

Query:  SRNVPKAPRNNKKTSNSETVTESMD-TTSSSSTMEVASNAVVKPKGKAAAPRKAPAKKGKGPVVNDDAKDDDEEVLELKDRLAAYKIDSSPDRSE--AME
        SRN PKAPRN+KKTSNSET+TESMD TTSSS+T EVA+N VVKPKGK AAPRKAPAKKGK  V++D   DDD+EVLELKDRLAAYK++SSP+ SE  AME
Subjt:  SRNVPKAPRNNKKTSNSETVTESMD-TTSSSSTMEVASNAVVKPKGKAAAPRKAPAKKGKGPVVNDDAKDDDEEVLELKDRLAAYKIDSSPDRSE--AME

Query:  TEVPQVQ-AAKKKEPTKRAPAKKKTTAKSVHISDNDTDDDNFEIKEVRPPAAKKGGGGRKTAANA---NTTKKREPAAKLGQKLITQMLSPAENTGISPE
        TEVP+VQ AAKKKEP+KRA AKKKTTAKS  ISD D+D+ +FEIKE+ PPAAKK GGGRK AANA    TTKK+EP A+LGQKLITQML P EN+GISPE
Subjt:  TEVPQVQ-AAKKKEPTKRAPAKKKTTAKSVHISDNDTDDDNFEIKEVRPPAAKKGGGGRKTAANA---NTTKKREPAAKLGQKLITQMLSPAENTGISPE

Query:  KKVRKIRASPFNKKSGSILGRTGIEEEEEEEEEEDGNEGKIMGSGSSETTEESAGVAP-ARGRSQRGNRTQVRYVISDSESEPEAVDSDFDDKDADFDED
        KKVRKIR SPFNKKSGS+LGR   +  EEEEE E GNEGK+MGS SSETT+E  G  P ARGRSQR NRTQVRYV+SDS+SEP   DSDFD+ +AD DED
Subjt:  KKVRKIRASPFNKKSGSILGRTGIEEEEEEEEEEDGNEGKIMGSGSSETTEESAGVAP-ARGRSQRGNRTQVRYVISDSESEPEAVDSDFDDKDADFDED

TrEMBL top hits

e value

%identity

Alignment

A0A6J1DGT3 DNA topoisomerase 2

0.0e+00

89.74

Show/hide

Query:  MAVEKKRPLQNSNAANVDQLPAGPKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMD
        MAVEKKRPLQNS  ANVD  PAGPKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMD
Subjt:  MAVEKKRPLQNSNAANVDQLPAGPKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMD

Query:  SLKVVIDAEQNCISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDAEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFSDNMGKKSE
        S+KVVID EQNCISVFNNGDGVPVE+HQEEKVYVPELIFGHLLTSSNYDD  KKTTGGRNGYGAKLTNIFSTEFVIETADGKR KKYKQVF DNMGKKSE
Subjt:  SLKVVIDAEQNCISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDAEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFSDNMGKKSE

Query:  PIIAKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASAFSSEPPKRYHVKPNERWEIVV
        P+I KCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLD+AGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSAS F +EPPKRYH+KPNERWEIVV
Subjt:  PIIAKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASAFSSEPPKRYHVKPNERWEIVV

Query:  TLSEGQFQQVSFVNGIATIKGGTHVDYISNQIANYVMNAVNKKNKNANVKAHNVKNYLWVFINALIDNPAFDSQTKETLTIRQNSFGSACDLTPEFLKNV
        TLSEGQFQQVSFVN IATIKGGTHVDYI+NQIANYVMN VNKKNKNANVKAHNVK+YLWVFINALIDNPAFDSQTKETLTIRQ+SFGS C+LTPEFLKNV
Subjt:  TLSEGQFQQVSFVNGIATIKGGTHVDYISNQIANYVMNAVNKKNKNANVKAHNVKNYLWVFINALIDNPAFDSQTKETLTIRQNSFGSACDLTPEFLKNV

Query:  ATKSGIMDSVLSWVNFKQSKDLKKTDGTKTEKINGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASNKQIM
        A+KSGIMDSVLSWVNFKQSKDLKKTDG KTEKI+GIEKLEDANCAGG+NSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREAS+KQI 
Subjt:  ATKSGIMDSVLSWVNFKQSKDLKKTDGTKTEKINGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASNKQIM

Query:  ENKEIQYIKQILGLQQGKEYNNAKALRYGHLMIMTDQDHDGSHIKGLLINFVHSFWPSLLRVPSFLVEFITPIVKATHKNGTVLSFYTMPEYESWKESLR
        ENKEIQYIKQILGLQQGKEYNN K LRYGHLMIMTDQDHDGSHIKGLLINF+HSFWPSLLRVPSFLVEFITPIVKATH+NGTVLSFYTMPEYESWKESLR
Subjt:  ENKEIQYIKQILGLQQGKEYNNAKALRYGHLMIMTDQDHDGSHIKGLLINFVHSFWPSLLRVPSFLVEFITPIVKATHKNGTVLSFYTMPEYESWKESLR

Query:  NNASGWSIKYYKGLGTSTSKEGREYFEQLAKHKKDFIWQDDNDGEAIELAFSKKKIEERKNWLRQFEPGTHLDQTGKLIKYSDFVNKELILFSMADLQRS
         NASGWSIKYYKGLGTSTSKEGREYFEQL KHKKDF+WQDD+DGEAIELAFSKKKIEERKNWLR FEPGTHLDQT KLIKYSDFVNKELILFSMADLQRS
Subjt:  NNASGWSIKYYKGLGTSTSKEGREYFEQLAKHKKDFIWQDDNDGEAIELAFSKKKIEERKNWLRQFEPGTHLDQTGKLIKYSDFVNKELILFSMADLQRS

Query:  IPSMVDGLKPGQRKILFCSFKRNFIKEAKISQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT
        IPS+VDGLKPGQRKILFCSFKRNFIKEAK+SQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT
Subjt:  IPSMVDGLKPGQRKILFCSFKRNFIKEAKISQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT

Query:  RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDIIRNVRRMLNSETLLPMDPWYRGFSGTIEKTATKEGGSSYTVS
        RFLFP+DDD+LLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDII NV+R+L+ ET++PMDPWY+GFSG IEKTATKEGG SYTVS
Subjt:  RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDIIRNVRRMLNSETLLPMDPWYRGFSGTIEKTATKEGGSSYTVS

Query:  GIIEEVSDTTLRVIELPVRKWTNDYKEFLDSVTRTYKNDKDKDKVAKEPFIEQADHHSDDKIVSIDVHLTEENMILAMQEGLMKKLKLTTTISTSNMHLF
        GIIEEVSDTTLR+ ELPVR+WTNDYKEFLDSVTR      DK+K AK+PFIEQADHHSDDK VSIDVHLTEENMILA+QEGL KK KLTTT+STSNMHLF
Subjt:  GIIEEVSDTTLRVIELPVRKWTNDYKEFLDSVTRTYKNDKDKDKVAKEPFIEQADHHSDDKIVSIDVHLTEENMILAMQEGLMKKLKLTTTISTSNMHLF

Query:  DANGVIKKYDTPEQILEEFFPLRLEYYEKRKRNLLENLEMELLKLENKVRFILAVVNGEIIVSNRRRVDLFHELQAKGFTPFPKKAKSVEPEVAGASNET
        D+NGVIKKYDTPEQILEEFFPLRLEYYEKRK NLLENLE ELL+LENKVRFILAVVNGEI+VSNRRRVDLFHELQAKGFTPFPKK KSVEPEVAGASNET
Subjt:  DANGVIKKYDTPEQILEEFFPLRLEYYEKRKRNLLENLEMELLKLENKVRFILAVVNGEIIVSNRRRVDLFHELQAKGFTPFPKKAKSVEPEVAGASNET

Query:  DEAEESPEVKGERVSDYEYLLALAIGNLTIEKVQELCNNRDKLKGEVEDLRKATPKSLWLCDLDSLEKELDEMDRADANAEEVRKQQR-KSNNDIKPKIS
        DEAEESPE KGERVSDY YLLALAIG LTIEKVQELCN+RD+LKGEVEDLRKATPKSLWL DLD+LEKELDEMDR DA AEEVRKQQR K+NND+KPKIS
Subjt:  DEAEESPEVKGERVSDYEYLLALAIGNLTIEKVQELCNNRDKLKGEVEDLRKATPKSLWLCDLDSLEKELDEMDRADANAEEVRKQQR-KSNNDIKPKIS

Query:  RN-VPKAPRNNKKTSNSETVTESMDTTSSSSTMEVASNAVVKPKGKAAAPRKAPAKKGKGPVVNDDAKDDDEEVLELKDRLAAYKIDSSPDRSEAMETEV
        RN  PKAPRN+KKT NSET+ ESMDTTSSS+TMEVASNAVVKPKGK AAPRKAPAKKGK  VVN +  DDD+EVLELKDRLAAYKIDSSPDRSEAMETEV
Subjt:  RN-VPKAPRNNKKTSNSETVTESMDTTSSSSTMEVASNAVVKPKGKAAAPRKAPAKKGKGPVVNDDAKDDDEEVLELKDRLAAYKIDSSPDRSEAMETEV

Query:  PQV-QAAKKKEPTKRAPAKKKTTAKSVHISDN-DTDDDNFEIKEVRPPAAKKGGGGRKTAANANTT------KKREPAA-KLGQKLITQMLSPAENTGIS
        PQV  AAKKKEP+KRAPAKKKTTAKS  ISDN D+DDD+FEIKEV PPAAKKGGG  + AANA TT      KKRE AA KLGQKLITQML P +NTGIS
Subjt:  PQV-QAAKKKEPTKRAPAKKKTTAKSVHISDN-DTDDDNFEIKEVRPPAAKKGGGGRKTAANANTT------KKREPAA-KLGQKLITQMLSPAENTGIS

Query:  PEKKVRKIRASPFNKKSGSILGRTGIEEEEEEEEEEDGNEGKIMGSGSSETTEESAGVAPARGRSQRGNRTQVRYVISDSESEPEAVDSDFDDKDADFDE
        PEKKVRK+RASPFNKKSGSILGR G  EEEEEE EE+GNEGKIMGS SSET EESAG  PARGRSQR NRTQV+YVISDS+S+P     + DDKD DFD+
Subjt:  PEKKVRKIRASPFNKKSGSILGRTGIEEEEEEEEEEDGNEGKIMGSGSSETTEESAGVAPARGRSQRGNRTQVRYVISDSESEPEAVDSDFDDKDADFDE

Query:  D
        +
Subjt:  D

A0A6J1DIB5 DNA topoisomerase 2

0.0e+00

89.62

Show/hide

Query:  MAVEKKRPLQNSNAANVDQLPAGPKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMD
        MAVEKKRPLQNS  ANVD  PAGPKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMD
Subjt:  MAVEKKRPLQNSNAANVDQLPAGPKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMD

Query:  SLKVVIDAEQNCISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDAEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFSDNMGKKSE
        S+KVVID EQNCISVFNNGDGVPVE+HQEEKVYVPELIFGHLLTSSNYDD  KKTTGGRNGYGAKLTNIFSTEFVIETADGKR KKYKQVF DNMGKKSE
Subjt:  SLKVVIDAEQNCISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDAEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFSDNMGKKSE

Query:  PIIAKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASAFSSEPPKRYHVKPNERWEIVV
        P+I KCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLD+AGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSAS F +EPPKRYH+KPNERWEIVV
Subjt:  PIIAKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASAFSSEPPKRYHVKPNERWEIVV

Query:  TLSEGQFQQVSFVNGIATIKGGTHVDYISNQIANYVMNAVNKKNKNANVKAHNVKNYLWVFINALIDNPAFDSQTKETLTIRQNSFGSACDLTPEFLKNV
        TLSEGQFQQVSFVN IATIKGGTHVDYI+NQIANYVMN VNKKNKNANVKAHNVK+YLWVFINALIDNPAFDSQTKETLTIRQ+SFGS C+LTPEFLKNV
Subjt:  TLSEGQFQQVSFVNGIATIKGGTHVDYISNQIANYVMNAVNKKNKNANVKAHNVKNYLWVFINALIDNPAFDSQTKETLTIRQNSFGSACDLTPEFLKNV

Query:  ATKSGIMDSVLSWVNFKQSKDLKKTDGTKTEKINGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASNKQIM
        A+KSGIMDSVLSWVNFKQSKDLKKTDG KTEKI+GIEKLEDANCAGG+NSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREAS+KQI 
Subjt:  ATKSGIMDSVLSWVNFKQSKDLKKTDGTKTEKINGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASNKQIM

Query:  ENKEIQYIKQILGLQQGKEYNNAKALRYGHLMIMTDQDHDGSHIKGLLINFVHSFWPSLLRVPSFLVEFITPIVKATHKNGTVLSFYTMPEYESWKESLR
        ENKEIQYIKQILGLQQGKEYNN K LRYGHLMIMTDQDHDGSHIKGLLINF+HSFWPSLLRVPSFLVEFITPIVKATH+NGTVLSFYTMPEYESWKESLR
Subjt:  ENKEIQYIKQILGLQQGKEYNNAKALRYGHLMIMTDQDHDGSHIKGLLINFVHSFWPSLLRVPSFLVEFITPIVKATHKNGTVLSFYTMPEYESWKESLR

Query:  NNASGWSIKYYKGLGTSTSKEGREYFEQLAKHKKDFIWQDDNDGEAIELAFSKKKIEERKNWLRQFEPGTHLDQTGKLIKYSDFVNKELILFSMADLQRS
         NASGWSIKYYKGLGTSTSKEGREYFEQL KHKKDF+WQDD+DGEAIELAFSKKKIEERKNWLR FEPGTHLDQT KLIKYSDFVNKELILFSMADLQRS
Subjt:  NNASGWSIKYYKGLGTSTSKEGREYFEQLAKHKKDFIWQDDNDGEAIELAFSKKKIEERKNWLRQFEPGTHLDQTGKLIKYSDFVNKELILFSMADLQRS

Query:  IPSMVDGLKPGQRKILFCSFKRNFIKEAKISQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT
        IPS+VDGLKPGQRKILFCSFKRNFIKEAK+SQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT
Subjt:  IPSMVDGLKPGQRKILFCSFKRNFIKEAKISQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT

Query:  RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDIIRNVRRMLNSETLLPMDPWYRGFSGTIEKTATKEGGSSYTVS
        RFLFP+DDD+LLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDII NV+R+L+ ET++PMDPWY+GFSG IEKTATKEGG SYTVS
Subjt:  RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDIIRNVRRMLNSETLLPMDPWYRGFSGTIEKTATKEGGSSYTVS

Query:  GIIEEVSDTTLRVIELPVRKWTNDYKEFLDSVTRTYKNDKDKDKVAKEPFIEQADHHSDDKIVSIDVHLTEENMILAMQEGLMKKLKLTTTISTSNMHLF
        GIIEEVSDTTLR+ ELPVR+WTNDYKEFLDSVTR      DK+K AK+PFIEQADHHSDDK VSIDVHLTEENMILA+QEGL KK KLTTT+STSNMHLF
Subjt:  GIIEEVSDTTLRVIELPVRKWTNDYKEFLDSVTRTYKNDKDKDKVAKEPFIEQADHHSDDKIVSIDVHLTEENMILAMQEGLMKKLKLTTTISTSNMHLF

Query:  DANGVIKKYDTPEQILEEFFPLRLEYYEKRKRNLLENLEMELLKLENKVRFILAVVNGEIIVSNRRRVDLFHELQAKGFTPFPKKAKSVEPEVAGASNET
        D+NGVIKKYDTPEQILEEFFPLRLEYYEKRK NLLENLE ELL+LENKVRFILAVVNGEI+VSNRRRVDLFHELQAKGFTPFPKK KSVEPEVAGASNET
Subjt:  DANGVIKKYDTPEQILEEFFPLRLEYYEKRKRNLLENLEMELLKLENKVRFILAVVNGEIIVSNRRRVDLFHELQAKGFTPFPKKAKSVEPEVAGASNET

Query:  DEAEESPEVKGERVSDYEYLLALAIGNLTIEKVQELCNNRDKLKGEVEDLRKATPKSLWLCDLDSLEKELDEMDRADANAEEVRKQQR-KSNNDIKPKIS
        DEAEESPE KGERVSDY YLLALAIG LTIEKVQELCN+RD+LKGEVEDLRKATPKSLWL DLD+LEKELDEMDR DA AEEVRKQQR K+NND+KPKIS
Subjt:  DEAEESPEVKGERVSDYEYLLALAIGNLTIEKVQELCNNRDKLKGEVEDLRKATPKSLWLCDLDSLEKELDEMDRADANAEEVRKQQR-KSNNDIKPKIS

Query:  RN-VPKAPRNNKKTSNSETVTESMDTTSSSSTMEVASNAVVKPKGKAAAPRKAPAKKGKGPVVNDDAKDDDEEVLELKDRLAAYKIDSSPDRSE--AMET
        RN  PKAPRN+KKT NSET+ ESMDTTSSS+TMEVASNAVVKPKGK AAPRKAPAKKGK  VVN +  DDD+EVLELKDRLAAYKIDSSPDRSE  AMET
Subjt:  RN-VPKAPRNNKKTSNSETVTESMDTTSSSSTMEVASNAVVKPKGKAAAPRKAPAKKGKGPVVNDDAKDDDEEVLELKDRLAAYKIDSSPDRSE--AMET

Query:  EVPQV-QAAKKKEPTKRAPAKKKTTAKSVHISDN-DTDDDNFEIKEVRPPAAKKGGGGRKTAANANTT------KKREPAA-KLGQKLITQMLSPAENTG
        EVPQV  AAKKKEP+KRAPAKKKTTAKS  ISDN D+DDD+FEIKEV PPAAKKGGG  + AANA TT      KKRE AA KLGQKLITQML P +NTG
Subjt:  EVPQV-QAAKKKEPTKRAPAKKKTTAKSVHISDN-DTDDDNFEIKEVRPPAAKKGGGGRKTAANANTT------KKREPAA-KLGQKLITQMLSPAENTG

Query:  ISPEKKVRKIRASPFNKKSGSILGRTGIEEEEEEEEEEDGNEGKIMGSGSSETTEESAGVAPARGRSQRGNRTQVRYVISDSESEPEAVDSDFDDKDADF
        ISPEKKVRK+RASPFNKKSGSILGR G  EEEEEE EE+GNEGKIMGS SSET EESAG  PARGRSQR NRTQV+YVISDS+S+P     + DDKD DF
Subjt:  ISPEKKVRKIRASPFNKKSGSILGRTGIEEEEEEEEEEDGNEGKIMGSGSSETTEESAGVAPARGRSQRGNRTQVRYVISDSESEPEAVDSDFDDKDADF

Query:  DED
        D++
Subjt:  DED

A0A6J1F3D6 DNA topoisomerase 2

0.0e+00

90.13

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Query:  MAVEKKRPLQNSNAANVDQLPAGPKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMD
        MAVEKKRPLQNSNAANVD  PAGPKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMD
Subjt:  MAVEKKRPLQNSNAANVDQLPAGPKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMD

Query:  SLKVVIDAEQNCISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDAEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFSDNMGKKSE
        SLKVVIDAEQN ISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDD EKKTTGGRNGYGAKLTNIFSTEFVIETADG+RLKKYKQVFSDNMGKKSE
Subjt:  SLKVVIDAEQNCISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDAEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFSDNMGKKSE

Query:  PIIAKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASAFSSEPPKRYHVKPNERWEIVV
        PII KCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVD YLKSA+AF +EPPKRYH++PNERWEIVV
Subjt:  PIIAKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASAFSSEPPKRYHVKPNERWEIVV

Query:  TLSEGQFQQVSFVNGIATIKGGTHVDYISNQIANYVMNAVNKKNKNANVKAHNVKNYLWVFINALIDNPAFDSQTKETLTIRQNSFGSACDLTPEFLKNV
        TLSEGQFQQVSFVNGIATIKGGTHVDYI+NQIANYVM  VNKKNKNANVKAHNVK+YLWVFINALIDNPAFDSQTKETLTIRQ+SFGSAC+LTP+FLKNV
Subjt:  TLSEGQFQQVSFVNGIATIKGGTHVDYISNQIANYVMNAVNKKNKNANVKAHNVKNYLWVFINALIDNPAFDSQTKETLTIRQNSFGSACDLTPEFLKNV

Query:  ATKSGIMDSVLSWVNFKQSKDLKKTDGTKTEKINGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASNKQIM
        ATKSGIMDSVLSWVNFKQSKDLKKTDG KTEKI+GIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREAS+KQI 
Subjt:  ATKSGIMDSVLSWVNFKQSKDLKKTDGTKTEKINGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASNKQIM

Query:  ENKEIQYIKQILGLQQGKEYNNAKALRYGHLMIMTDQDHDGSHIKGLLINFVHSFWPSLLRVPSFLVEFITPIVKATHKNGTVLSFYTMPEYESWKESLR
        ENKEIQYIKQILGLQQGKEYNNAKALRYGHLMIMTDQDHDGSHIKGLLINF+HSFWPSLLRVPSFLVEFITPIVKATH+NGTVLSFYTMPEYE+WK++LR
Subjt:  ENKEIQYIKQILGLQQGKEYNNAKALRYGHLMIMTDQDHDGSHIKGLLINFVHSFWPSLLRVPSFLVEFITPIVKATHKNGTVLSFYTMPEYESWKESLR

Query:  NNASGWSIKYYKGLGTSTSKEGREYFEQLAKHKKDFIWQDDNDGEAIELAFSKKKIEERKNWLRQFEPGTHLDQTGKLIKYSDFVNKELILFSMADLQRS
         NASGWSIKYYKGLGTSTSKEGREYFEQLAKHKKDFIWQD++DGEAIELAFSKKKIEERKNWLRQFE GTHLDQ+ KLIKYSDFVNKELILFSMADLQRS
Subjt:  NNASGWSIKYYKGLGTSTSKEGREYFEQLAKHKKDFIWQDDNDGEAIELAFSKKKIEERKNWLRQFEPGTHLDQTGKLIKYSDFVNKELILFSMADLQRS

Query:  IPSMVDGLKPGQRKILFCSFKRNFIKEAKISQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT
        IPSMVDGLKPGQRKILFCSFKRNFIKEAK+SQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLSN T
Subjt:  IPSMVDGLKPGQRKILFCSFKRNFIKEAKISQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT

Query:  RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDIIRNVRRMLNSETLLPMDPWYRGFSGTIEKTATKEGGSSYTVS
        RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSY+PNYNPRDIIRNVRRMLN E +LPMDPWYRGFSGTIEKTATKEGG+SYTVS
Subjt:  RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDIIRNVRRMLNSETLLPMDPWYRGFSGTIEKTATKEGGSSYTVS

Query:  GIIEEVSDTTLRVIELPVRKWTNDYKEFLDSVTR-TYKNDKDKDKVAKEPFIEQADHHSDDKIVSIDVHLTEENMILAMQEGLMKKLKLTTTISTSNMHL
        GIIEEVSDTTLR+ ELPVR+WTNDYK+FLDSVTR + KNDKDK+K AK+PFIEQADHHSDDK VSIDVHLTEENMILAMQEGL KK KLTTT+STSNMHL
Subjt:  GIIEEVSDTTLRVIELPVRKWTNDYKEFLDSVTR-TYKNDKDKDKVAKEPFIEQADHHSDDKIVSIDVHLTEENMILAMQEGLMKKLKLTTTISTSNMHL

Query:  FDANGVIKKYDTPEQILEEFFPLRLEYYEKRKRNLLENLEMELLKLENKVRFILAVVNGEIIVSNRRRVDLFHELQAKGFTPFPKKAKSVEPEVAGASNE
        FDANGVIKKYDTPEQILEEFFPLRLE++EKRKRNLLENLE ELLKLENKVRFILAVVNGEIIVSNRRRVDLFHELQ KGFTPFPKK KSVEPEVAGASNE
Subjt:  FDANGVIKKYDTPEQILEEFFPLRLEYYEKRKRNLLENLEMELLKLENKVRFILAVVNGEIIVSNRRRVDLFHELQAKGFTPFPKKAKSVEPEVAGASNE

Query:  TDEAEESPE-VKGERVSDYEYLLALAIGNLTIEKVQELCNNRDKLKGEVEDLRKATPKSLWLCDLDSLEKELDEMDRADANAEEVRKQQRKSNNDIKPKI
        TDEAEESPE VKGERVSDYEYLLALAIG LTIEKVQELCN RDK KGEVE+LRKATPKSLWL DLD LEKELDEMDR DA A+EVRKQQR  NNDIKPKI
Subjt:  TDEAEESPE-VKGERVSDYEYLLALAIGNLTIEKVQELCNNRDKLKGEVEDLRKATPKSLWLCDLDSLEKELDEMDRADANAEEVRKQQRKSNNDIKPKI

Query:  SRNVPKAPRNNKKTSNSETVTESMD-TTSSSSTMEVASNAVVKPKGKAAAPRKAPAKKGKGPVVNDDAKDDDEEVLELKDRLAAYKIDSSPDRSE--AME
        SRN PKAPRN+KKTSNSET+TESMD TTSSS+T EVA+N VVKPKGK AAPRKAPAKKGK  V++D   DDD+EVLELKDRLAAYK++SSP+ SE  AME
Subjt:  SRNVPKAPRNNKKTSNSETVTESMD-TTSSSSTMEVASNAVVKPKGKAAAPRKAPAKKGKGPVVNDDAKDDDEEVLELKDRLAAYKIDSSPDRSE--AME

Query:  TEVPQVQ-AAKKKEPTKRAPAKKKTTAKSVHISDNDTDDDNFEIKEVRPPAAKKGGGGRKTAANA---NTTKKREPAAKLGQKLITQMLSPAENTGISPE
        TEVP+VQ AAKKKEP+KRA AKKKTTAKS  ISD D+DD +FEIKE+ PPAAKK GGGRK AANA    TTKK+EP A+LGQKLITQML P EN+GISPE
Subjt:  TEVPQVQ-AAKKKEPTKRAPAKKKTTAKSVHISDNDTDDDNFEIKEVRPPAAKKGGGGRKTAANA---NTTKKREPAAKLGQKLITQMLSPAENTGISPE

Query:  KKVRKIRASPFNKKSGSILGRTGIEEEEEEEEEEDGNEGKIMGSGSSETTEESAGVAP-ARGRSQRGNRTQVRYVISDSESEPEAVDSDFDDKDADFDED
        KKVRKIR SPFNKKSGS+LGR     EEEEE EE GNEGK+MGS SSETT+E     P ARGRSQR NRTQVRYV+SDS+SEP   DSDFD+ +A+ DED
Subjt:  KKVRKIRASPFNKKSGSILGRTGIEEEEEEEEEEDGNEGKIMGSGSSETTEESAGVAP-ARGRSQRGNRTQVRYVISDSESEPEAVDSDFDDKDADFDED

A0A6J1F9E0 DNA topoisomerase 2

0.0e+00

90.07

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Query:  MAVEKKRPLQNSNAANVDQLPAGPKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMD
        MAVEKKRPLQNSNAANVD  PAGPKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMD
Subjt:  MAVEKKRPLQNSNAANVDQLPAGPKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMD

Query:  SLKVVIDAEQNCISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDAEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFSDNMGKKSE
        SLKVVIDAEQN ISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDD EKKTTGGRNGYGAKLTNIFSTEFVIETADG+RLKKYKQVFSDNMGKKSE
Subjt:  SLKVVIDAEQNCISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDAEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFSDNMGKKSE

Query:  PIIAKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASAFSSEPPKRYHVKPNERWEIVV
        PII KCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVD YLKSA+AF +EPPKRYH++PNERWEIVV
Subjt:  PIIAKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASAFSSEPPKRYHVKPNERWEIVV

Query:  TLSEGQFQQVSFVNGIATIKGGTHVDYISNQIANYVMNAVNKKNKNANVKAHNVKNYLWVFINALIDNPAFDSQTKETLTIRQNSFGSACDLTPEFLKNV
        TLSEGQFQQVSFVNGIATIKGGTHVDYI+NQIANYVM  VNKKNKNANVKAHNVK+YLWVFINALIDNPAFDSQTKETLTIRQ+SFGSAC+LTP+FLKNV
Subjt:  TLSEGQFQQVSFVNGIATIKGGTHVDYISNQIANYVMNAVNKKNKNANVKAHNVKNYLWVFINALIDNPAFDSQTKETLTIRQNSFGSACDLTPEFLKNV

Query:  ATKSGIMDSVLSWVNFKQSKDLKKTDGTKTEKINGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASNKQIM
        ATKSGIMDSVLSWVNFKQSKDLKKTDG KTEKI+GIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREAS+KQI 
Subjt:  ATKSGIMDSVLSWVNFKQSKDLKKTDGTKTEKINGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASNKQIM

Query:  ENKEIQYIKQILGLQQGKEYNNAKALRYGHLMIMTDQDHDGSHIKGLLINFVHSFWPSLLRVPSFLVEFITPIVKATHKNGTVLSFYTMPEYESWKESLR
        ENKEIQYIKQILGLQQGKEYNNAKALRYGHLMIMTDQDHDGSHIKGLLINF+HSFWPSLLRVPSFLVEFITPIVKATH+NGTVLSFYTMPEYE+WK++LR
Subjt:  ENKEIQYIKQILGLQQGKEYNNAKALRYGHLMIMTDQDHDGSHIKGLLINFVHSFWPSLLRVPSFLVEFITPIVKATHKNGTVLSFYTMPEYESWKESLR

Query:  NNASGWSIKYYKGLGTSTSKEGREYFEQLAKHKKDFIWQDDNDGEAIELAFSKKKIEERKNWLRQFEPGTHLDQTGKLIKYSDFVNKELILFSMADLQRS
         NASGWSIKYYKGLGTSTSKEGREYFEQLAKHKKDFIWQD++DGEAIELAFSKKKIEERKNWLRQFE GTHLDQ+ KLIKYSDFVNKELILFSMADLQRS
Subjt:  NNASGWSIKYYKGLGTSTSKEGREYFEQLAKHKKDFIWQDDNDGEAIELAFSKKKIEERKNWLRQFEPGTHLDQTGKLIKYSDFVNKELILFSMADLQRS

Query:  IPSMVDGLKPGQRKILFCSFKRNFIKEAKISQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT
        IPSMVDGLKPGQRKILFCSFKRNFIKEAK+SQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLSN T
Subjt:  IPSMVDGLKPGQRKILFCSFKRNFIKEAKISQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT

Query:  RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDIIRNVRRMLNSETLLPMDPWYRGFSGTIEKTATKEGGSSYTVS
        RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSY+PNYNPRDIIRNVRRMLN E +LPMDPWYRGFSGTIEKTATKEGG+SYTVS
Subjt:  RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDIIRNVRRMLNSETLLPMDPWYRGFSGTIEKTATKEGGSSYTVS

Query:  GIIEEVSDTTLRVIELPVRKWTNDYKEFLDSVTR-TYKNDKDKDKVAKEPFIEQADHHSDDKIVSIDVHLTEENMILAMQEGLMKKLKLTTTISTSNMHL
        GIIEEVSDTTLR+ ELPVR+WTNDYK+FLDSVTR + KNDKDK+K AK+PFIEQADHHSDDK VSIDVHLTEENMILAMQEGL KK KLTTT+STSNMHL
Subjt:  GIIEEVSDTTLRVIELPVRKWTNDYKEFLDSVTR-TYKNDKDKDKVAKEPFIEQADHHSDDKIVSIDVHLTEENMILAMQEGLMKKLKLTTTISTSNMHL

Query:  FDANGVIKKYDTPEQILEEFFPLRLEYYEKRKRNLLENLEMELLKLENKVRFILAVVNGEIIVSNRRRVDLFHELQAKGFTPFPKKAKSVEPEVAGASNE
        FDANGVIKKYDTPEQILEEFFPLRLE++EKRKRNLLENLE ELLKLENKVRFILAVVNGEIIVSNRRRVDLFHELQ KGFTPFPKK KSVEPEVAGASNE
Subjt:  FDANGVIKKYDTPEQILEEFFPLRLEYYEKRKRNLLENLEMELLKLENKVRFILAVVNGEIIVSNRRRVDLFHELQAKGFTPFPKKAKSVEPEVAGASNE

Query:  TDEAEESPE-VKGERVSDYEYLLALAIGNLTIEKVQELCNNRDKLKGEVEDLRKATPKSLWLCDLDSLEKELDEMDRADANAEEVRKQQRKSNNDIKPKI
        TDEAEESPE VKGERVSDYEYLLALAIG LTIEKVQELCN RDK KGEVE+LRKATPKSLWL DLD LEKELDEMDR DA A+EVRKQQR  NNDIKPKI
Subjt:  TDEAEESPE-VKGERVSDYEYLLALAIGNLTIEKVQELCNNRDKLKGEVEDLRKATPKSLWLCDLDSLEKELDEMDRADANAEEVRKQQRKSNNDIKPKI

Query:  SRNVPKAPRNNKKTSNSETVTESMD-TTSSSSTMEVASNAVVKPKGKAAAPRKAPAKK-GKGPVVNDDAKDDDEEVLELKDRLAAYKIDSSPDRSE--AM
        SRN PKAPRN+KKTSNSET+TESMD TTSSS+T EVA+N VVKPKGK AAPRKAPAKK GK  V++D   DDD+EVLELKDRLAAYK++SSP+ SE  AM
Subjt:  SRNVPKAPRNNKKTSNSETVTESMD-TTSSSSTMEVASNAVVKPKGKAAAPRKAPAKK-GKGPVVNDDAKDDDEEVLELKDRLAAYKIDSSPDRSE--AM

Query:  ETEVPQVQ-AAKKKEPTKRAPAKKKTTAKSVHISDNDTDDDNFEIKEVRPPAAKKGGGGRKTAANA---NTTKKREPAAKLGQKLITQMLSPAENTGISP
        ETEVP+VQ AAKKKEP+KRA AKKKTTAKS  ISD D+DD +FEIKE+ PPAAKK GGGRK AANA    TTKK+EP A+LGQKLITQML P EN+GISP
Subjt:  ETEVPQVQ-AAKKKEPTKRAPAKKKTTAKSVHISDNDTDDDNFEIKEVRPPAAKKGGGGRKTAANA---NTTKKREPAAKLGQKLITQMLSPAENTGISP

Query:  EKKVRKIRASPFNKKSGSILGRTGIEEEEEEEEEEDGNEGKIMGSGSSETTEESAGVAP-ARGRSQRGNRTQVRYVISDSESEPEAVDSDFDDKDADFDE
        EKKVRKIR SPFNKKSGS+LGR     EEEEE EE GNEGK+MGS SSETT+E     P ARGRSQR NRTQVRYV+SDS+SEP   DSDFD+ +A+ DE
Subjt:  EKKVRKIRASPFNKKSGSILGRTGIEEEEEEEEEEDGNEGKIMGSGSSETTEESAGVAP-ARGRSQRGNRTQVRYVISDSESEPEAVDSDFDDKDADFDE

Query:  D
        D
Subjt:  D

A0A6J1J555 DNA topoisomerase 2

0.0e+00

89.87

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Query:  MAVEKKRPLQNSNAANVDQLPAGPKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMD
        MAVE KRPLQNSNAANVD  PAGPKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLW+YENDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMD
Subjt:  MAVEKKRPLQNSNAANVDQLPAGPKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMD

Query:  SLKVVIDAEQNCISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDAEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFSDNMGKKSE
        SLKVVIDAEQNCISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDD EKKTTGGRNGYGAKLTNIFSTEFVIETADG+RLKKYKQVFSDNMGKKSE
Subjt:  SLKVVIDAEQNCISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDAEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFSDNMGKKSE

Query:  PIIAKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASAFSSEPPKRYHVKPNERWEIVV
        PII KCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVD YLKSA+AF +EPPKRYH++PNERWEIVV
Subjt:  PIIAKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASAFSSEPPKRYHVKPNERWEIVV

Query:  TLSEGQFQQVSFVNGIATIKGGTHVDYISNQIANYVMNAVNKKNKNANVKAHNVKNYLWVFINALIDNPAFDSQTKETLTIRQNSFGSACDLTPEFLKNV
        TLSEGQFQQVSFVNGIATIKGGTHVDYI+NQIANYVM  VNKKNKNANVKAHNVK+YLWVFINALIDNPAFDSQTKETLTIRQ+SFGSAC+LTP+FLKNV
Subjt:  TLSEGQFQQVSFVNGIATIKGGTHVDYISNQIANYVMNAVNKKNKNANVKAHNVKNYLWVFINALIDNPAFDSQTKETLTIRQNSFGSACDLTPEFLKNV

Query:  ATKSGIMDSVLSWVNFKQSKDLKKTDGTKTEKINGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASNKQIM
        ATKSGIMDSVLSWVNFKQSKDLKKTDG KTEKI+GIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREAS+KQI 
Subjt:  ATKSGIMDSVLSWVNFKQSKDLKKTDGTKTEKINGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASNKQIM

Query:  ENKEIQYIKQILGLQQGKEYNNAKALRYGHLMIMTDQDHDGSHIKGLLINFVHSFWPSLLRVPSFLVEFITPIVKATHKNGTVLSFYTMPEYESWKESLR
        ENKEIQYIKQILGLQQGKEYNNAKALRYGHLMIMTDQDHDGSHIKGLLINF+HSFWPSLLRVPSFLVEFITPIVKATH+NGTVLSFYTMPEYE+WK++LR
Subjt:  ENKEIQYIKQILGLQQGKEYNNAKALRYGHLMIMTDQDHDGSHIKGLLINFVHSFWPSLLRVPSFLVEFITPIVKATHKNGTVLSFYTMPEYESWKESLR

Query:  NNASGWSIKYYKGLGTSTSKEGREYFEQLAKHKKDFIWQDDNDGEAIELAFSKKKIEERKNWLRQFEPGTHLDQTGKLIKYSDFVNKELILFSMADLQRS
         NASGWSIKYYKGLGTSTSKEGREYFEQLAKHKKDFIWQD++DGEAIELAFSKKKIEERKNWLRQFE GTHLDQ+ KLIKYSDFVNKELILFSMADLQRS
Subjt:  NNASGWSIKYYKGLGTSTSKEGREYFEQLAKHKKDFIWQDDNDGEAIELAFSKKKIEERKNWLRQFEPGTHLDQTGKLIKYSDFVNKELILFSMADLQRS

Query:  IPSMVDGLKPGQRKILFCSFKRNFIKEAKISQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT
        IPSMVDGLKPGQRKILFCSFKRNFIKEAK+SQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLSN T
Subjt:  IPSMVDGLKPGQRKILFCSFKRNFIKEAKISQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT

Query:  RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDIIRNVRRMLNSETLLPMDPWYRGFSGTIEKTATKEGGSSYTVS
        RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSY+PNYNPRDIIRNVRRML+ E +LPMDPWYRGFSGTIEKTATKEGG+SYTVS
Subjt:  RFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDIIRNVRRMLNSETLLPMDPWYRGFSGTIEKTATKEGGSSYTVS

Query:  GIIEEVSDTTLRVIELPVRKWTNDYKEFLDSVTR-TYKNDKDKDKVAKEPFIEQADHHSDDKIVSIDVHLTEENMILAMQEGLMKKLKLTTTISTSNMHL
        GIIEEVSDTTLR+ ELPVR+WTNDYK+FLDSVTR + KNDKDK+K AK+PFIEQADHHSDDK VSI+VHLTEENMILAMQEGL KK KLTTT+STSNMHL
Subjt:  GIIEEVSDTTLRVIELPVRKWTNDYKEFLDSVTR-TYKNDKDKDKVAKEPFIEQADHHSDDKIVSIDVHLTEENMILAMQEGLMKKLKLTTTISTSNMHL

Query:  FDANGVIKKYDTPEQILEEFFPLRLEYYEKRKRNLLENLEMELLKLENKVRFILAVVNGEIIVSNRRRVDLFHELQAKGFTPFPKKAKSVEPEVAGASNE
        FDANGVIKKYDTPEQILEEFFPLRLE++EKRKRNLLENLE ELLKLENKVRFILAVVNGEIIVSNRRRVDLFHELQ KGFTPFPKK KSVEPEVAGASNE
Subjt:  FDANGVIKKYDTPEQILEEFFPLRLEYYEKRKRNLLENLEMELLKLENKVRFILAVVNGEIIVSNRRRVDLFHELQAKGFTPFPKKAKSVEPEVAGASNE

Query:  TDEAEESPE-VKGERVSDYEYLLALAIGNLTIEKVQELCNNRDKLKGEVEDLRKATPKSLWLCDLDSLEKELDEMDRADANAEEVRKQQRKSNNDIKPKI
        TDEAEESPE VKGERVSDYEYLLALAIG LTIEKVQELCN RDK KGEVE+LRKATPKSLWL DLD LEKELDEMDR DA A+EVRKQQR  NNDIKPKI
Subjt:  TDEAEESPE-VKGERVSDYEYLLALAIGNLTIEKVQELCNNRDKLKGEVEDLRKATPKSLWLCDLDSLEKELDEMDRADANAEEVRKQQRKSNNDIKPKI

Query:  SRNVPKAPRNNKKTSNSETVTESMD-TTSSSSTMEVASNAVVKPKGKAAAPRKAPAKKGKGPVVNDDAKDDDEEVLELKDRLAAYKIDSSPDRSE--AME
        SRN PKAPRN+KKTSNSET+TESMD  TSSS+T EVA+N VVKPKGK AAPRKAPAKKGK  V++DD    D+EVLELKDRLAAYK++SSP+ SE  AME
Subjt:  SRNVPKAPRNNKKTSNSETVTESMD-TTSSSSTMEVASNAVVKPKGKAAAPRKAPAKKGKGPVVNDDAKDDDEEVLELKDRLAAYKIDSSPDRSE--AME

Query:  TEVPQVQ-AAKKKEPTKRAPAKKKTTAKSVHISDNDTDDDNFEIKEVRPPAAKKGGGGRKTAANA---NTTKKREPAAKLGQKLITQMLSPAENTGISPE
        TEVP+VQ AAKKKEP+KRA AKKKTTAKS  ISD D+DD +FEIKE+ PPAAKK GGGRK AANA    TTKK+EP A+LGQKLITQML P EN+GISPE
Subjt:  TEVPQVQ-AAKKKEPTKRAPAKKKTTAKSVHISDNDTDDDNFEIKEVRPPAAKKGGGGRKTAANA---NTTKKREPAAKLGQKLITQMLSPAENTGISPE

Query:  KKVRKIRASPFNKKSGSILGRTGIEEEEEEEEEEDGNEGKIMGSGSSETTEESAGVAP-ARGRSQRGNRTQVRYVISDSESEPEAVDSDFDDKDADFDED
        KKVRKIR SPFNKKSGS+LGR     EEEEE EE GNEGK+MGS SSETT+E     P ARGRSQR NRTQVRYV+SDS+SEP   DSDFD+ +AD DED
Subjt:  KKVRKIRASPFNKKSGSILGRTGIEEEEEEEEEEDGNEGKIMGSGSSETTEESAGVAP-ARGRSQRGNRTQVRYVISDSESEPEAVDSDFDDKDADFDED

SwissProt top hits

e value

%identity

Alignment

O24308 DNA topoisomerase 2

0.0e+00

63.37

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Query:  KKRPLQNSNAANVDQLPAGPKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMDSLKV
        +KRPLQ SNAAN+      P KTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYEND+MVHR+V+YVPGLYKIFDEILVNAADNKQRDPSMDSLKV
Subjt:  KKRPLQNSNAANVDQLPAGPKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMDSLKV

Query:  VIDAEQNCISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDAEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFSDNMGKKSEPIIA
         ID E N +SV+NNGDGVPVE+HQEEKVYVPELIFGHLLTSSNYDD  KKTTGGRNGYGAKLTNIFSTEF+IETADG+RLKKYKQVFS+NMG K EP+I 
Subjt:  VIDAEQNCISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDAEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFSDNMGKKSEPIIA

Query:  KCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASAFSSEPPKRYHVKPNERWEIVVTLSE
        KCK  +NWTKVTFKPDL KF M +LE+DVVALMKKRVLD+AGC GKTVKVELNG  +  KSF+DY DL+LK A      P  R H K  +RWEI ++LS+
Subjt:  KCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASAFSSEPPKRYHVKPNERWEIVVTLSE

Query:  GQFQQVSFVNGIATIKGGTHVDYISNQIANYVMNAVNKKNKNANVKAHNVKNYLWVFINALIDNPAFDSQTKETLTIRQNSFGSACDLTPEFLKNVATKS
        GQFQQVSFVN IATIKGGTHVDYI+NQI  Y+MN VNKK K+ANVKAH VKN+LWVF+N+LIDNPAFDSQTKETLT RQ SFGS CD+    LK+V  KS
Subjt:  GQFQQVSFVNGIATIKGGTHVDYISNQIANYVMNAVNKKNKNANVKAHNVKNYLWVFINALIDNPAFDSQTKETLTIRQNSFGSACDLTPEFLKNVATKS

Query:  GIMDSVLSWVNFKQSKDLKKTDGTKTEKINGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASNKQIMENKE
        GI+D++LSW +FKQSKDLKKTDGTKT+++ G  K EDAN AGG+NSEKCTLILTEGDSAKALAMAGL VVGRD YGVFPLRGKLLNVREAS+KQIM+N+E
Subjt:  GIMDSVLSWVNFKQSKDLKKTDGTKTEKINGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASNKQIMENKE

Query:  IQYIKQILGLQQGKEYNNAKALRYGHLMIMTDQDHDGSHIKGLLINFVHSFWPSLLRVPSFLVEFITPIVKATHKNGTVLSFYTMPEYESWKESLRNNAS
        IQ IK+ILGLQQ KEY N K+LRYGHLMIM DQDHDGSHIKGLLINF+HSFWPSLL+VPSFLVEF TP+++A+H N T+ SFY+MPEYE+WKE L N+A+
Subjt:  IQYIKQILGLQQGKEYNNAKALRYGHLMIMTDQDHDGSHIKGLLINFVHSFWPSLLRVPSFLVEFITPIVKATHKNGTVLSFYTMPEYESWKESLRNNAS

Query:  GWSIKYYKGLGTSTSKEGREYFEQLAKHKKDFIWQDDNDGEAIELAFSKKKIEERKNWLRQFEPGTHLDQTGKLIKYSDFVNKELILFSMADLQRSIPSM
         W IKYYKGLGTST +EGREYF  L +H+KDFIW D+ DG AIELAFSKKK E RK W+R FEPGT  D   KLI Y DFVNKELILFS AD        
Subjt:  GWSIKYYKGLGTSTSKEGREYFEQLAKHKKDFIWQDDNDGEAIELAFSKKKIEERKNWLRQFEPGTHLDQTGKLIKYSDFVNKELILFSMADLQRSIPSM

Query:  VDGLKPGQRKILFCSFKRNFIKEAKISQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVTRFLF
                   LF SFK+   KE K++QF GYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLL PNGQFGT N GGKDHAS+RYIYT+LS VTR LF
Subjt:  VDGLKPGQRKILFCSFKRNFIKEAKISQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVTRFLF

Query:  PKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDIIRNVRRMLNSETLLPMDPWYRGFSGTIEKTATKEGGSSYTVSGIIE
         + DDKLL YLNEDG+SIEP WYMPIIP VLVNGSEGIGTGWSSY+PNYNPR+II NVRR+LN E L+PMDPWY+GF GTIEK+A KEGG  Y V+G + 
Subjt:  PKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDIIRNVRRMLNSETLLPMDPWYRGFSGTIEKTATKEGGSSYTVSGIIE

Query:  EVSDTTLRVIELPVRKWTNDYKEFLDSVTRTYKNDKDKDKVAKEPFIEQADHHSDDKIVSIDVHLTEENMILAMQEGLMKKLKLTTTISTSNMHLFDANG
        E+ + T R+ ELP+RKWT DYK+FL+S+T    N KD       P IE    + DD IV I++ +  E +   +QEGL KK KLT+TISTSNMHLFDA G
Subjt:  EVSDTTLRVIELPVRKWTNDYKEFLDSVTRTYKNDKDKDKVAKEPFIEQADHHSDDKIVSIDVHLTEENMILAMQEGLMKKLKLTTTISTSNMHLFDANG

Query:  VIKKYDTPEQILEEFFPLRLEYYEKRKRNLLENLEMELLKLENKVRFILAVVNGEIIVSNRRRVDLFHELQAKGFTPFPKKAKSVEPEVAGASNETDEAE
          KK+DTPEQILEEFFPLRL+YYEK K  +L NL   LL L+NKVRFIL VVNGEIIVSNR++ +L  EL+ KGFTP P+K KS +P+VAGA+++  E +
Subjt:  VIKKYDTPEQILEEFFPLRLEYYEKRKRNLLENLEMELLKLENKVRFILAVVNGEIIVSNRRRVDLFHELQAKGFTPFPKKAKSVEPEVAGASNETDEAE

Query:  ESPE---------VKGERVSDYEYLLALAIGNLTIEKVQELCNNRDKLKGEVEDLRKATPKSLWLCDLDSLEKELDEMDRADANAEEVRKQQ-RKSNNDI
        E  E         V+G    DY+ LL+L IG LT+E VQ+L + + + + E E L      SLWL DLD  EK+LDE+D   A  +  R  Q  K  N  
Subjt:  ESPE---------VKGERVSDYEYLLALAIGNLTIEKVQELCNNRDKLKGEVEDLRKATPKSLWLCDLDSLEKELDEMDRADANAEEVRKQQ-RKSNNDI

Query:  KPKISRNVPKAPRNNKKTSNSETVTESMDTTSSSSTMEVASNAVVKPKGKAAAPRKAPAKKGKGPVVNDDAKDDDEEVLELKDRLAAYKIDSSPDRSEAM
          K ++  P+  +N KK        +S++  + +S+ME+  NAV     +AA P +    KG+     +  K+ ++++  L++RLAAY I+SS ++S+AM
Subjt:  KPKISRNVPKAPRNNKKTSNSETVTESMDTTSSSSTMEVASNAVVKPKGKAAAPRKAPAKKGKGPVVNDDAKDDDEEVLELKDRLAAYKIDSSPDRSEAM

Query:  ETEVPQVQAAKKKEPTKRAPAKKKTTAKSVHISD----NDTDDDNFEIKEVRPPAAKKGGGGRKTAA-NANTTKKREPA--------------AKLGQKL
        E+E  Q +AA KK+  KR  AKKK++   +        ND DDD+ + +EV+  AA    GGRK AA NA     + PA                 GQKL
Subjt:  ETEVPQVQAAKKKEPTKRAPAKKKTTAKSVHISD----NDTDDDNFEIKEVRPPAAKKGGGGRKTAA-NANTTKKREPA--------------AKLGQKL

Query:  ITQMLSPAENTGISPEKKVRKIRASPFNKKSGSILGRTGIEEEEEEEEEEDGNEGKIMGSGSSETTEESAGVAPARGRSQRGNRTQVRYVISDSESEPEA
        +T ML PAE TG SPEKKVRK+R SPFNKKSGSILGR      ++     D + G    +  SE         PAR R QR NRTQ++Y +S+SESE   
Subjt:  ITQMLSPAENTGISPEKKVRKIRASPFNKKSGSILGRTGIEEEEEEEEEEDGNEGKIMGSGSSETTEESAGVAPARGRSQRGNRTQVRYVISDSESEPEA

Query:  VDSDFDDKDADFDED
         DSD D + +DF+ED
Subjt:  VDSDFDDKDADFDED

O46374 DNA topoisomerase 2-alpha

0.0e+00

46.46

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Query:  MAVEKKRPLQNSNAANVDQLPAGPKK--TIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMV-HRSVTYVPGLYKIFDEILVNAADNKQRDP
        M V   +P+  +   N  +     KK  +IE +YQKKTQLEHILLRPDTY+GS+E  TQ +WVY+ D  + +R VT+VPGLYKIFDEILVNAADNKQRDP
Subjt:  MAVEKKRPLQNSNAANVDQLPAGPKK--TIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMV-HRSVTYVPGLYKIFDEILVNAADNKQRDP

Query:  SMDSLKVVIDAEQNCISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDAEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFSDNMGK
         M  ++V ID E N IS++NNG G+PV  H+ EK+YVP LIFG LLTSSNYDD EKK TGGRNGYGAKL NIFST+F +ETA  +  K +KQ + DNMG+
Subjt:  SMDSLKVVIDAEQNCISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDAEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFSDNMGK

Query:  KSEPIIAKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASAFSSEPPKRYHVKPNERWE
          E +  K   G+++T +TF PDL+KF M  L+ D+VALM +R  D+AG   K VKV LNG ++PVK F+ YVDLYLK     +  P K  H + N RWE
Subjt:  KSEPIIAKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASAFSSEPPKRYHVKPNERWE

Query:  IVVTLSEGQFQQVSFVNGIATIKGGTHVDYISNQIANYVMNAVNKKNK-NANVKAHNVKNYLWVFINALIDNPAFDSQTKETLTIRQNSFGSACDLTPEF
        + +T+SE  FQQ+SFVN IAT KGG HVDY+++QI   +++ V KKNK    VKAH VKN++W+F+NALI+NP FDSQTKE +T++  SFGS C L+ +F
Subjt:  IVVTLSEGQFQQVSFVNGIATIKGGTHVDYISNQIANYVMNAVNKKNK-NANVKAHNVKNYLWVFINALIDNPAFDSQTKETLTIRQNSFGSACDLTPEF

Query:  LKNVATKSGIMDSVLSWVNFKQSKDL-KKTDGTKTEKINGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREAS
        +K  A   GI++S+L+WV FK    L KK    K  +I GI KL+DAN AGG+NS +CTLILTEGDSAK LA++GLGVVGRD YGVFPLRGK+LNVREAS
Subjt:  LKNVATKSGIMDSVLSWVNFKQSKDL-KKTDGTKTEKINGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREAS

Query:  NKQIMENKEIQYIKQILGLQQGKEY---NNAKALRYGHLMIMTDQDHDGSHIKGLLINFVHSFWPSLLRVPSFLVEFITPIVKATHKNGTVLSFYTMPEY
        +KQIMEN EI  I +I+GLQ  K Y   ++ K LRYG +MIMTDQD DGSHIKGLLINF+H  WPSLLR   FL EFITPIVK + KN   ++FY++PE+
Subjt:  NKQIMENKEIQYIKQILGLQQGKEY---NNAKALRYGHLMIMTDQDHDGSHIKGLLINFVHSFWPSLLRVPSFLVEFITPIVKATHKNGTVLSFYTMPEY

Query:  ESWKESLRNNASGWSIKYYKGLGTSTSKEGREYFEQLAKHKKDFIWQDDNDGEAIELAFSKKKIEERKNWLRQFE-----------PGTHL-DQTGKLIK
        E WK S  N+   W +KYYKGLGTSTSKE +EYF  + +H+  F +    D  AI LAFSKK+I++RK WL  F            P  +L  QT   + 
Subjt:  ESWKESLRNNASGWSIKYYKGLGTSTSKEGREYFEQLAKHKKDFIWQDDNDGEAIELAFSKKKIEERKNWLRQFE-----------PGTHL-DQTGKLIK

Query:  YSDFVNKELILFSMADLQRSIPSMVDGLKPGQRKILFCSFKRNFIKEAKISQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRN
        Y+DF+NKELILFS +D +RSIPSMVDGLKPGQRK+LF  FKRN  +E K++Q +G V+E S+YHHGE SL  TII +AQ+FVGSNN+NLL P GQFGTR 
Subjt:  YSDFVNKELILFSMADLQRSIPSMVDGLKPGQRKILFCSFKRNFIKEAKISQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRN

Query:  HGGKDHASSRYIYTKLSNVTRFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDIIRNVRRMLNSETLLPMDPWYRG
        HGGKD AS RYI+T LS + R LFP  DD  L +L +D Q +EP WY+PIIP VL+NG+EGIGTGWS  +PN++ R+++ N+R +++ E  LPM P Y+ 
Subjt:  HGGKDHASSRYIYTKLSNVTRFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDIIRNVRRMLNSETLLPMDPWYRG

Query:  FSGTIEKTATKEGGSSYTVSGIIEEVSDTTLRVIELPVRKWTNDYKEFLDSVTRTYKNDKDKDKVAKEPFIEQADHHSDDKIVSIDVHLTEENMILAMQE
        F GTIE+ A  +    Y +SG +  ++ TT+ + ELP+R WT  YKE    V     N  +K      P I     +  D  V   V +TEE +  A + 
Subjt:  FSGTIEKTATKEGGSSYTVSGIIEEVSDTTLRVIELPVRKWTNDYKEFLDSVTRTYKNDKDKDKVAKEPFIEQADHHSDDKIVSIDVHLTEENMILAMQE

Query:  GLMKKLKLTTTISTSNMHLFDANGVIKKYDTPEQILEEFFPLRLEYYEKRKRNLLENLEMELLKLENKVRFILAVVNGEIIVSNRRRVDLFHELQAKGFT
        GL K  KL T+++ ++M LFD  G +KKYDT   IL +FF LRL+YY  RK  LL  L  E  KL N+ RFIL  ++G+II+ N+ + +L   L  +G+ 
Subjt:  GLMKKLKLTTTISTSNMHLFDANGVIKKYDTPEQILEEFFPLRLEYYEKRKRNLLENLEMELLKLENKVRFILAVVNGEIIVSNRRRVDLFHELQAKGFT

Query:  PFPKKAKSVEPEVAGASNETDEAEESPEV-KGERVSD----YEYLLALAIGNLTIEKVQELCNNRDKLKGEVEDLRKATPKSLWLCDLDSLEKELDEMDR
          P KA     +      E +E++   E  K + V+D    + YLL + +  LT EK  ELC  R++ + E+E L++ +P  LW  DL +  +EL+ ++ 
Subjt:  PFPKKAKSVEPEVAGASNETDEAEESPEV-KGERVSD----YEYLLALAIGNLTIEKVQELCNNRDKLKGEVEDLRKATPKSLWLCDLDSLEKELDEMDR

Query:  ADANAEEV--------RKQQRKSNNDIKPK------ISRNVPKAPRNNKKTSNSETVTESMDTTSSSSTMEVAS-----------NAVVKPKGKAAAPRK
         +   E++         K ++    ++ P       I R   +     +K    +  +E+ + +     MEV                 K K +   P K
Subjt:  ADANAEEV--------RKQQRKSNNDIKPK------ISRNVPKAPRNNKKTSNSETVTESMDTTSSSSTMEVAS-----------NAVVKPKGKAAAPRK

Query:  APAKKGKGPVVNDDAKDD---DEEVL-----ELKDRLAAYK------IDSSPDRSEAMETE-----VPQVQAAKKKEPTKRAPAKKKTTAKSV-HISDND
         P KK K      D++ D   DE        E + R AA K      +DS  D S+A E       VP   + +K E + +   K+    KS   +SD D
Subjt:  APAKKGKGPVVNDDAKDD---DEEVL-----ELKDRLAAYK------IDSSPDRSEAMETE-----VPQVQAAKKKEPTKRAPAKKKTTAKSV-HISDND

Query:  TDD--DNF------------EIKEVRPPAAKKGGGGRKTAA----NANTTKKREPAAKLGQKLITQMLSPAENTGISPEKKVRKIRASPFNKKSGS
         DD  DN              + E   P +KK    +KTAA    + +TT  ++ AA  G K    + S        P+ K R+ R    +  S S
Subjt:  TDD--DNF------------EIKEVRPPAAKKGGGGRKTAA----NANTTKKREPAAKLGQKLITQMLSPAENTGISPEKKVRKIRASPFNKKSGS

P08096 DNA topoisomerase 2

0.0e+00

46.17

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Query:  IEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVY--ENDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMDSLKVVIDAEQNCISVFNNGDGVPVE
        +   YQ+ T  EH+L RPDTY+GSIE  T  +WV+  E +K+ +++VTYVPGLYKIFDEI+VNAADNK RDP+M++LKV +D E N IS++NNG G+P+E
Subjt:  IEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVY--ENDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMDSLKVVIDAEQNCISVFNNGDGVPVE

Query:  VHQEEKVYVPELIFGHLLTSSNYDDAEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFSDNMGKKSEPIIAKCKEGDNWTKVTFKPDLAKFN
        +H +EK+Y+PELIFG+LLTSSNYDD +KK TGGRNGYGAKL NIFSTEFV+ETAD +R+KKYKQ + DNM +KSEP+I   K+ D +TK+TFKPDLAKF 
Subjt:  VHQEEKVYVPELIFGHLLTSSNYDDAEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFSDNMGKKSEPIIAKCKEGDNWTKVTFKPDLAKFN

Query:  MTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASAFSSEPPKRYHVKPNERWEIVVTLSEGQFQQVSFVNGIATIKGGTHV
        M  ++DD+V+++K+R+ D+AG + +T KV LN +R+ +  F+ YV++YL S +    EPP+  +   N+RW++   +S+GQF+QVSFVN I+TI+GGTHV
Subjt:  MTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASAFSSEPPKRYHVKPNERWEIVVTLSEGQFQQVSFVNGIATIKGGTHV

Query:  DYISNQIANYVMNAVNKKNKNANVKAHNVKNYLWVFINALIDNPAFDSQTKETLTIRQNSFGSACDLTPEFLKNVATKSGIMDSVLSWVNFKQSKDLKKT
        +Y++N+I + +   V K+NK A VKA  +KNY+ VF+N  I+NP+FDSQTKETLT + ++FGS C L+ +FLK +  KS +++ VL +   K  + L K 
Subjt:  DYISNQIANYVMNAVNKKNKNANVKAHNVKNYLWVFINALIDNPAFDSQTKETLTIRQNSFGSACDLTPEFLKNVATKSGIMDSVLSWVNFKQSKDLKKT

Query:  DGTKTEKINGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASNKQIMENKEIQYIKQILGLQQGKEYNNAKA
        DG    +I G+ KLEDAN AG K S KC LILTEGDSAK+LA++GL VVGRD+YGVFPLRGKLLNVREAS+ QI+ NKEIQ IK+I+G    K Y + K 
Subjt:  DGTKTEKINGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASNKQIMENKEIQYIKQILGLQQGKEYNNAKA

Query:  LRYGHLMIMTDQDHDGSHIKGLLINFVHSFWPSLLRVPSFLVEFITPIVKATHKNGTVLSFYTMPEYESWKESLRNNASGWSIKYYKGLGTSTSKEGREY
        LRYGHLMIMTDQDHDGSHIKGL+IN++ S +PSLL++P FL++FITPI+K T  N  V +FYT+PEYE WKE+  NN  GW IKYYKGLGTS   + + Y
Subjt:  LRYGHLMIMTDQDHDGSHIKGLLINFVHSFWPSLLRVPSFLVEFITPIVKATHKNGTVLSFYTMPEYESWKESLRNNASGWSIKYYKGLGTSTSKEGREY

Query:  FEQLAKHKKDFIWQDDNDGEAIELAFSKKKIEERKNWLRQFEPGTHLDQTGKLIKYSDFVNKELILFSMADLQRSIPSMVDGLKPGQRKILFCSFKRNFI
        F  L +H K F    + D E IE+AF+KKK + RK WLR + PG ++D T   I   DF+N+ELI FSMAD  RSIPS+VDGLKPGQRK+++  FKRN +
Subjt:  FEQLAKHKKDFIWQDDNDGEAIELAFSKKKIEERKNWLRQFEPGTHLDQTGKLIKYSDFVNKELILFSMADLQRSIPSMVDGLKPGQRKILFCSFKRNFI

Query:  KEAKISQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVTRFLFPKDDDKLLNYLNEDGQSIEPT
         E K+S+ +GYV+  +AYHHGE S+  TI+ +AQ+FVGSNNINLL+PNGQFGTR+ GGK+ ++SRY+ T LS + R LF  +DD+LLNY N++GQ IEP 
Subjt:  KEAKISQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVTRFLFPKDDDKLLNYLNEDGQSIEPT

Query:  WYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDIIRNVRRMLNSETLLPMDPWYRGFSGTIEKTATKEGGSSYTVSGIIEEVSDTTLRVIELPVRKWTNDY
        +Y+PI+P VLVNG+EGIGTGWS+++PNYNP+DI  N+R MLN E L  M PWYRGF G+I K A       Y +SGII ++ +  + + ELP+R WT D 
Subjt:  WYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDIIRNVRRMLNSETLLPMDPWYRGFSGTIEKTATKEGGSSYTVSGIIEEVSDTTLRVIELPVRKWTNDY

Query:  KEFLDSVTRTYKNDKDKDKVAKEPFIEQADHHSDDKIVSIDVHLTEENMILAMQEGLMKKLKLTTTISTSNMHLFDANGVIKKYDTPEQILEEFFPLRLE
        KE+L++           +K+ K  FI   + H  +  V  +V LTE  M  A+ E L  K KL+ T +TSNM  FDA+G IKKYD+ E IL EF+ +RL 
Subjt:  KEFLDSVTRTYKNDKDKDKVAKEPFIEQADHHSDDKIVSIDVHLTEENMILAMQEGLMKKLKLTTTISTSNMHLFDANGVIKKYDTPEQILEEFFPLRLE

Query:  YYEKRKRNLLENLEMELLKLENKVRFILAVVNGEIIVSNRRRVDLFHELQAKGFTPF--PKKAKSVEPEVAGASNETDEAEESPEVKGERVSD-YEYLLA
         Y++RK +++  LE    +  N+ RFI  ++ GE++VS +++ DL  EL+ K F P   PKK   V+ EV    N   E E+S +V  +  SD Y YLL+
Subjt:  YYEKRKRNLLENLEMELLKLENKVRFILAVVNGEIIVSNRRRVDLFHELQAKGFTPF--PKKAKSVEPEVAGASNETDEAEESPEVKGERVSD-YEYLLA

Query:  LAIGNLTIEKVQELCNNRDKLKGEVEDLRKATPKSLWLCDLDSLE----KELDEMDRADANAEEVRKQQRKSNNDIKPKISRNVPKAPRNNKKTSNSETV
        + + +LT E+  EL   +D++  E++ L K TPK LWL DLD+ E    K +D++ R +   EE   +   +    KP+      + PR    +S+S  V
Subjt:  LAIGNLTIEKVQELCNNRDKLKGEVEDLRKATPKSLWLCDLDSLE----KELDEMDRADANAEEVRKQQRKSNNDIKPKISRNVPKAPRNNKKTSNSETV

Query:  TESMDTTSSSSTMEVASNAVVKPKGKAAAPRKAPAKKGKGPVVNDDAKDDDEEVLELKDRLAAYKIDSSPDRSEAMETEVPQVQAAKKKEPTKRAPAKKK
         +   + S  ST       +++      A  K P K     +V  +                        D S  +  E  ++  +   + +    ++K+
Subjt:  TESMDTTSSSSTMEVASNAVVKPKGKAAAPRKAPAKKGKGPVVNDDAKDDDEEVLELKDRLAAYKIDSSPDRSEAMETEVPQVQAAKKKEPTKRAPAKKK

Query:  TTAKSVHISDNDTDDDNFEIKEVRPPAAKKGGGGRKTAANANTTKKREPAAKLGQKLITQMLSPAENTGISPEKKVRKIRASPFNKKSGSILGRTGIEEE
                S +   +D    K V+  AA   G GRKT     TT     ++     L+   L P+  T      K +  +AS   K+S          E+
Subjt:  TTAKSVHISDNDTDDDNFEIKEVRPPAAKKGGGGRKTAANANTTKKREPAAKLGQKLITQMLSPAENTGISPEKKVRKIRASPFNKKSGSILGRTGIEEE

Query:  EEEEEEEDGNEGKIMGSGSSETTEESAGVAPARGRSQRGNRTQVRYVI-----SDSESEPEAVDSDF-DDKDADFDE
        ++++    G+      S ++    E +  +P R R  R     V+  I      DS  EP   D  F  D D D D+
Subjt:  EEEEEEEDGNEGKIMGSGSSETTEESAGVAPARGRSQRGNRTQVRYVI-----SDSESEPEAVDSDF-DDKDADFDE

P11388 DNA topoisomerase 2-alpha

0.0e+00

46.42

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Query:  MAVEKKRPLQNSNAANVDQLPAGPKK--TIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMV-HRSVTYVPGLYKIFDEILVNAADNKQRDP
        M V   +P+  +   N  +     KK  ++E +YQKKTQLEHILLRPDTY+GS+E  TQ +WVY+ D  + +R VT+VPGLYKIFDEILVNAADNKQRDP
Subjt:  MAVEKKRPLQNSNAANVDQLPAGPKK--TIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMV-HRSVTYVPGLYKIFDEILVNAADNKQRDP

Query:  SMDSLKVVIDAEQNCISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDAEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFSDNMGK
         M  ++V ID E N IS++NNG G+PV  H+ EK+YVP LIFG LLTSSNYDD EKK TGGRNGYGAKL NIFST+F +ETA  +  K +KQ + DNMG+
Subjt:  SMDSLKVVIDAEQNCISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDAEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFSDNMGK

Query:  KSEPIIAKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASAFSSEPPKRYHVKPNERWE
          E +  K   G+++T +TF+PDL+KF M  L+ D+VALM +R  D+AG   K VKV LNG ++PVK F+ YVD+YLK     +    K  H + N RWE
Subjt:  KSEPIIAKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASAFSSEPPKRYHVKPNERWE

Query:  IVVTLSEGQFQQVSFVNGIATIKGGTHVDYISNQIANYVMNAVNKKNK-NANVKAHNVKNYLWVFINALIDNPAFDSQTKETLTIRQNSFGSACDLTPEF
        + +T+SE  FQQ+SFVN IAT KGG HVDY+++QI   +++ V KKNK    VKAH VKN++W+F+NALI+NP FDSQTKE +T++  SFGS C L+ +F
Subjt:  IVVTLSEGQFQQVSFVNGIATIKGGTHVDYISNQIANYVMNAVNKKNK-NANVKAHNVKNYLWVFINALIDNPAFDSQTKETLTIRQNSFGSACDLTPEF

Query:  LKNVATKSGIMDSVLSWVNFKQSKDL-KKTDGTKTEKINGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREAS
        +K  A   GI++S+L+WV FK    L KK    K  +I GI KL+DAN AGG+NS +CTLILTEGDSAK LA++GLGVVGRD YGVFPLRGK+LNVREAS
Subjt:  LKNVATKSGIMDSVLSWVNFKQSKDL-KKTDGTKTEKINGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREAS

Query:  NKQIMENKEIQYIKQILGLQQGKEY---NNAKALRYGHLMIMTDQDHDGSHIKGLLINFVHSFWPSLLRVPSFLVEFITPIVKATHKNGTVLSFYTMPEY
        +KQIMEN EI  I +I+GLQ  K Y   ++ K LRYG +MIMTDQD DGSHIKGLLINF+H  WPSLLR   FL EFITPIVK + KN   ++FY++PE+
Subjt:  NKQIMENKEIQYIKQILGLQQGKEY---NNAKALRYGHLMIMTDQDHDGSHIKGLLINFVHSFWPSLLRVPSFLVEFITPIVKATHKNGTVLSFYTMPEY

Query:  ESWKESLRNNASGWSIKYYKGLGTSTSKEGREYFEQLAKHKKDFIWQDDNDGEAIELAFSKKKIEERKNWLRQFE-----------PGTHL-DQTGKLIK
        E WK S  N+   W +KYYKGLGTSTSKE +EYF  + +H+  F +    D  AI LAFSKK+I++RK WL  F            P  +L  QT   + 
Subjt:  ESWKESLRNNASGWSIKYYKGLGTSTSKEGREYFEQLAKHKKDFIWQDDNDGEAIELAFSKKKIEERKNWLRQFE-----------PGTHL-DQTGKLIK

Query:  YSDFVNKELILFSMADLQRSIPSMVDGLKPGQRKILFCSFKRNFIKEAKISQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRN
        Y+DF+NKELILFS +D +RSIPSMVDGLKPGQRK+LF  FKRN  +E K++Q +G V+E S+YHHGE SL  TII +AQ+FVGSNN+NLL P GQFGTR 
Subjt:  YSDFVNKELILFSMADLQRSIPSMVDGLKPGQRKILFCSFKRNFIKEAKISQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRN

Query:  HGGKDHASSRYIYTKLSNVTRFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDIIRNVRRMLNSETLLPMDPWYRG
        HGGKD AS RYI+T LS++ R LFP  DD  L +L +D Q +EP WY+PIIP VL+NG+EGIGTGWS  +PN++ R+I+ N+RR+++ E  LPM P Y+ 
Subjt:  HGGKDHASSRYIYTKLSNVTRFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDIIRNVRRMLNSETLLPMDPWYRG

Query:  FSGTIEKTATKEGGSSYTVSGIIEEVSDTTLRVIELPVRKWTNDYKEFLDSVTRTYKNDKDKDKVAKEPFIEQADHHSDDKIVSIDVHLTEENMILAMQE
        F GTIE+ A  +    Y +SG +  ++ TT+ + ELPVR WT  YKE    V     N  +K      P I     +  D  V   V +TEE +  A + 
Subjt:  FSGTIEKTATKEGGSSYTVSGIIEEVSDTTLRVIELPVRKWTNDYKEFLDSVTRTYKNDKDKDKVAKEPFIEQADHHSDDKIVSIDVHLTEENMILAMQE

Query:  GLMKKLKLTTTISTSNMHLFDANGVIKKYDTPEQILEEFFPLRLEYYEKRKRNLLENLEMELLKLENKVRFILAVVNGEIIVSNRRRVDLFHELQAKGFT
        GL K  KL T+++ ++M LFD  G +KKYDT   IL +FF LRL+YY  RK  LL  L  E  KL N+ RFIL  ++G+II+ N+ + +L   L  +G+ 
Subjt:  GLMKKLKLTTTISTSNMHLFDANGVIKKYDTPEQILEEFFPLRLEYYEKRKRNLLENLEMELLKLENKVRFILAVVNGEIIVSNRRRVDLFHELQAKGFT

Query:  PFPKKA-KSVEPEVAGASNETDEAEESPEVKGERVSD----YEYLLALAIGNLTIEKVQELCNNRDKLKGEVEDLRKATPKSLWLCDLDSLEKELDEMDR
          P KA K  + +V       +   E    K + V+D    + YLL + +  LT EK  ELC  R++ + E++ L++ +P  LW  DL +  +EL+ ++ 
Subjt:  PFPKKA-KSVEPEVAGASNETDEAEESPEVKGERVSD----YEYLLALAIGNLTIEKVQELCNNRDKLKGEVEDLRKATPKSLWLCDLDSLEKELDEMDR

Query:  ADANAEEV----------RKQQRKSNNDIKPKISRNVPK--------APRNNKKTSNSETVTESMDTTSSSSTMEVASNAVVKPKGKAAAPRK-------
         +   E+V           K+ + +     P+  R +P+        A + NKK   +E  TE            +      K K +     K       
Subjt:  ADANAEEV----------RKQQRKSNNDIKPKISRNVPK--------APRNNKKTSNSETVTESMDTTSSSSTMEVASNAVVKPKGKAAAPRK-------

Query:  APAKKGKGPVVNDDAKDD--------DEEVLELKDRLAAYK------IDSSPDRSEAMETE-----VPQVQAAKKKEPTKRAPAKKKTTAKSVHISDNDT
         P KKGK      D++ D        D    E + R AA K      +DS  D S+  E       VP   +  K + + +   K+    KSV +SD + 
Subjt:  APAKKGKGPVVNDDAKDD--------DEEVLELKDRLAAYK------IDSSPDRSEAMETE-----VPQVQAAKKKEPTKRAPAKKKTTAKSVHISDNDT

Query:  DDDNFEI--------------KEVRPPAAKKGGGGRKTAA----NANTTKKREPAAKLGQKLITQMLSPAENTGISPEKKVRKIRASPFNKKSGS
        DD    +               E+  P  KK    +KTAA    + +TT  ++ AA  G K       PA N+G+S +    K +     K S S
Subjt:  DDDNFEI--------------KEVRPPAAKKGGGGRKTAA----NANTTKKREPAAKLGQKLITQMLSPAENTGISPEKKVRKIRASPFNKKSGS

P30182 DNA topoisomerase 2

0.0e+00

62.35

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Query:  KRPLQNSNAANVDQLPAGPK-----KTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMD
        K PLQNSNAANV + PA  +     KTIEEMYQKK+QLEHILLRPDTY+GSIEKHTQ LWVYE D+MV R VTYVPGLYKIFDEILVNAADNKQRD  MD
Subjt:  KRPLQNSNAANVDQLPAGPK-----KTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMD

Query:  SLKVVIDAEQNCISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDAEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFSDNMGKKSE
        S++VVID EQN ISV N+G GVPVE+HQEE +YVPE+IFGHLLTSSNYDD  KKTTGGRNGYGAKLTNIFSTEF+IETADGKRLKKYKQVF +NMGKKSE
Subjt:  SLKVVIDAEQNCISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDAEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFSDNMGKKSE

Query:  PIIAKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASAFSSEPP-KRYHVKPNERWEIV
        P+I KC + +NWTKVTFKPDL KFNMT LEDDVVALM KRV D+AGCLGK+VKVELNG+++PVKSF DYVDLYL +A+   +E P  R   K N+RWE+ 
Subjt:  PIIAKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASAFSSEPP-KRYHVKPNERWEIV

Query:  VTLSEGQFQQVSFVNGIATIKGGTHVDYISNQIANYVMNAVNKKNKNANVKAHNVKNYLWVFINALIDNPAFDSQTKETLTIRQNSFGSACDLTPEFLKN
        V+LSEGQFQQVSFVN IATIKGGTHVDY+++QI N+++ AVNKKNKNANVKAHNVKN+LWVF+NALIDNPAFDSQTKETLT+RQ+SFGS C+L+ +FLK 
Subjt:  VTLSEGQFQQVSFVNGIATIKGGTHVDYISNQIANYVMNAVNKKNKNANVKAHNVKNYLWVFINALIDNPAFDSQTKETLTIRQNSFGSACDLTPEFLKN

Query:  VATKSGIMDSVLSWVNFKQSKDLKKTDGTKTEKINGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASNKQI
        V  KSG+++++LSW +FKQ+KDLKK+DG KT ++  +EKL+DA  AGGKNS  CTLILTEGDSAK+LA+AG  V+G ++ GVFPLRGKLLNVREAS  QI
Subjt:  VATKSGIMDSVLSWVNFKQSKDLKKTDGTKTEKINGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASNKQI

Query:  MENKEIQYIKQILGLQQGKEYNNAKALRYGHLMIMTDQDHDGSHIKGLLINFVHSFWPSLLRVPSFLVEFITPIVKATHKNGT--VLSFYTMPEYESWKE
          NKEI+ +K+ILGL+Q  +Y N  +LRYG +MIMTDQDHDGSHIKGLLINF+HSFWPSLL+VPSFLVEFITPIVKAT K GT  VLSFY+MPEYE WKE
Subjt:  MENKEIQYIKQILGLQQGKEYNNAKALRYGHLMIMTDQDHDGSHIKGLLINFVHSFWPSLLRVPSFLVEFITPIVKATHKNGT--VLSFYTMPEYESWKE

Query:  SLRNNASGWSIKYYKGLGTSTSKEGREYFEQLAKHKKDFIWQDDNDGEAIELAFSKKKIEERKNWLRQFEPGTHLDQTGKLIKYSDFVNKELILFSMADL
        SL+ NA+GW IKYYKGLGTST++EG+EYF  L  HKKDF+W+D+ DGEAIELAFSKKKIE RKNWL  + PG HLDQ    + YSDFVNKELILFSMADL
Subjt:  SLRNNASGWSIKYYKGLGTSTSKEGREYFEQLAKHKKDFIWQDDNDGEAIELAFSKKKIEERKNWLRQFEPGTHLDQTGKLIKYSDFVNKELILFSMADL

Query:  QRSIPSMVDGLKPGQRKILFCSFKRNFIKEAKISQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLS
        QRSIPSMVDGLKPGQRKILF +FK+   KE K++Q  GYVS  SAYHHGEQSLAS IIGMAQD+VGSNNINLLLPNGQFGTR  GGKD AS+RYI+TKLS
Subjt:  QRSIPSMVDGLKPGQRKILFCSFKRNFIKEAKISQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLS

Query:  NVTRFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDIIRNVRRMLNSETLLPMDPWYRGFSGTIEKTATKEGGSSY
         VTR LFPKDDD LL+YLNEDGQ IEPTWYMPIIPTVLVNG+EGIGTGWS+++PNYNPR+I+ NVRR+LN E+++PMDPWYRGF GTIEKTA+KEGG +Y
Subjt:  NVTRFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDIIRNVRRMLNSETLLPMDPWYRGFSGTIEKTATKEGGSSY

Query:  TVSGIIEEVSDTTLRVIELPVRKWTNDYKEFLDSVTRTYKNDKDKDKVAKEPFIEQADHHSDDKIVSIDVHLTEENMILAMQEGLMKKLKLTTTISTSNM
        T++G+ EEV +TT+R+ ELP+R+W +DYK FL S+    K D         PF +    ++D+K V  D+ L+EENM+ A QEG +KK KLTTTI+TSNM
Subjt:  TVSGIIEEVSDTTLRVIELPVRKWTNDYKEFLDSVTRTYKNDKDKDKVAKEPFIEQADHHSDDKIVSIDVHLTEENMILAMQEGLMKKLKLTTTISTSNM

Query:  HLFDANGVIKKYDTPEQILEEFFPLRLEYYEKRKRNLLENLEMELLKLENKVRFILAVVNGEIIVSNRRRVDLFHELQAKGFTPFPKKAKSVEPEVAGAS
        HLFD  GVIKKY TPEQILEEFF LR EYYEKRK  +++N+E+ELLKLENK RFILAV++GEIIV+ R++ D+  +L+ KGFTPFP+KA+SVE  +AGA 
Subjt:  HLFDANGVIKKYDTPEQILEEFFPLRLEYYEKRKRNLLENLEMELLKLENKVRFILAVVNGEIIVSNRRRVDLFHELQAKGFTPFPKKAKSVEPEVAGAS

Query:  NETDEAEE------SPEVKGERV--SDYEYLLALAIGNLTIEKVQELCNNRDKLKGEVEDLRKATPKSLWLCDLDSLEKELDEMDRADANAE---EVRKQ
        ++ D AEE       PE     +  S+Y+YLLA+AI +LTIEKV+EL  +RDK+   V D++K TPKSLWL DL+SL+KEL+++D  DA  +   E  ++
Subjt:  NETDEAEE------SPEVKGERV--SDYEYLLALAIGNLTIEKVQELCNNRDKLKGEVEDLRKATPKSLWLCDLDSLEKELDEMDRADANAE---EVRKQ

Query:  QRKSNNDIKPKISRNVPKAP---RNNKKTSNSET-----------------------------VTESMDTTSSSSTMEVASNA--VVKPKGKAAAPRKAP
        + ++ +    K+ R  PK P   +  KK S SET                              +ES  T +S S M+  +N   VVKPKG+  A +KAP
Subjt:  QRKSNNDIKPKISRNVPKAP---RNNKKTSNSET-----------------------------VTESMDTTSSSSTMEVASNA--VVKPKGKAAAPRKAP

Query:  AKKGKGPVVNDDAKD-DDEEVLELKDRLAAYKIDSSPDRSEAMETEVPQVQAAKKKEPTKRAPAKKKTTAKSVHISDNDTDDDNFEIKEVRPPAAKKGGG
        A           AK+ +++E+L+L  RLA Y   S+P  S                       +K   T+K++ + D+D D     + EV P   KK  G
Subjt:  AKKGKGPVVNDDAKD-DDEEVLELKDRLAAYKIDSSPDRSEAMETEVPQVQAAKKKEPTKRAPAKKKTTAKSVHISDNDTDDDNFEIKEVRPPAAKKGGG

Query:  GRKTAANANTTKKREPAA--KLGQKLI--TQMLSPAENTGISPEKKVRKIRASPFNKKSGSILGRTGIEEEEEEEEEEDGNEGKIMGSGSSETTEESAGV
        GRK AA   T   + PAA  K G++ +  T++L+     G+SPEKKVRK+R+SPFNKKS S++ R    +EEE  E   GN           ++E+S G 
Subjt:  GRKTAANANTTKKREPAA--KLGQKLI--TQMLSPAENTGISPEKKVRKIRASPFNKKSGSILGRTGIEEEEEEEEEEDGNEGKIMGSGSSETTEESAGV

Query:  APARGRSQRGNRTQVRYVISDSESEPEAVDSDFDDKDADFDED
          A  R QR NR ++ YV+SDSESE  A DS+FDD + D D++
Subjt:  APARGRSQRGNRTQVRYVISDSESEPEAVDSDFDDKDADFDED

Arabidopsis top hits

e value

%identity

Alignment

AT3G10270.1 DNA GYRASE B1

1.3e-22

23.84

Show/hide

Query:  GLYKIFDEILVNAADNKQRDPSMDSLKVVIDAEQNCISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDAEK--KTTGGRNGYGAKLTNIFSTEF
        GL+ +  EIL NA D  Q       + VV+ ++ + +S+ +NG G+P ++H        E +   L     +         +GG +G G  + N  S   
Subjt:  GLYKIFDEILVNAADNKQRDPSMDSLKVVIDAEQNCISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDAEK--KTTGGRNGYGAKLTNIFSTEF

Query:  -VIETADGKRLKKYKQVFSDNMGKKSEP----IIAKCKEGDNWTKVTFKPDLAKFNMT-HLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQD
         VI   DG    +++Q +S   GK        ++     G   T + F PD   F      + + +A   + +  L   +  ++K E +     V S   
Subjt:  -VIETADGKRLKKYKQVFSDNMGKKSEP----IIAKCKEGDNWTKVTFKPDLAKFNMT-HLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQD

Query:  YVDLYLKSASAFSSEPPKRYHVKPNERWEIVVTLSEGQFQ---------QVSFVNGIATIKGGTHVDYISNQIANYVMNAVNKKNKNANVKAHNVKNYLW
        Y     +  S  +++  K  H     R EI  +  +   Q          + + N I TI GGTH++ +   +    +N++ KK K   VK + + +  W
Subjt:  YVDLYLKSASAFSSEPPKRYHVKPNERWEIVVTLSEGQFQ---------QVSFVNGIATIKGGTHVDYISNQIANYVMNAVNKKNKNANVKAHNVKNYLW

Query:  V-------------------------------------FINALIDNPAFDSQTKETL---TIR-------QNSFGSACDLTPEFLKNVATKSGIMDSVLS
        +                                      ++  + NP F+ QTK  L    +R       Q       +L P+ L+++ +KS  +++  +
Subjt:  V-------------------------------------FINALIDNPAFDSQTKETL---TIR-------QNSFGSACDLTPEFLKNVATKSGIMDSVLS

Query:  WVNFKQSKDLKKTDGT-KTEKINGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASNKQIMENKEIQYIKQI
         +  K++++L ++    K+  + G  KL D +      SE   + + EGDSA   A  G     R F  + PLRGK+LN+       + +N+EIQ +   
Subjt:  WVNFKQSKDLKKTDGT-KTEKINGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASNKQIMENKEIQYIKQI

Query:  LGLQQGKEYNNAKALRYGHLMIMTDQDHDGSHIKGLLINFVHSFWPSLLRVPSFLVEFITPIVKATHKNGTVLSFYTMPEYESWKESLRNNASGWSIKYY
        LGL    E  N + LRY  ++I+TD D DG+HI+ LL+ F   +  +L       V  + P+ K   +       Y     +    S   NAS ++I+ +
Subjt:  LGLQQGKEYNNAKALRYGHLMIMTDQDHDGSHIKGLLINFVHSFWPSLLRVPSFLVEFITPIVKATHKNGTVLSFYTMPEYESWKESLRNNASGWSIKYY

Query:  KGLG
        KGLG
Subjt:  KGLG

AT3G23890.1 topoisomerase II

0.0e+00

62.35

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Query:  KRPLQNSNAANVDQLPAGPK-----KTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMD
        K PLQNSNAANV + PA  +     KTIEEMYQKK+QLEHILLRPDTY+GSIEKHTQ LWVYE D+MV R VTYVPGLYKIFDEILVNAADNKQRD  MD
Subjt:  KRPLQNSNAANVDQLPAGPK-----KTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMD

Query:  SLKVVIDAEQNCISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDAEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFSDNMGKKSE
        S++VVID EQN ISV N+G GVPVE+HQEE +YVPE+IFGHLLTSSNYDD  KKTTGGRNGYGAKLTNIFSTEF+IETADGKRLKKYKQVF +NMGKKSE
Subjt:  SLKVVIDAEQNCISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDAEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFSDNMGKKSE

Query:  PIIAKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASAFSSEPP-KRYHVKPNERWEIV
        P+I KC + +NWTKVTFKPDL KFNMT LEDDVVALM KRV D+AGCLGK+VKVELNG+++PVKSF DYVDLYL +A+   +E P  R   K N+RWE+ 
Subjt:  PIIAKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASAFSSEPP-KRYHVKPNERWEIV

Query:  VTLSEGQFQQVSFVNGIATIKGGTHVDYISNQIANYVMNAVNKKNKNANVKAHNVKNYLWVFINALIDNPAFDSQTKETLTIRQNSFGSACDLTPEFLKN
        V+LSEGQFQQVSFVN IATIKGGTHVDY+++QI N+++ AVNKKNKNANVKAHNVKN+LWVF+NALIDNPAFDSQTKETLT+RQ+SFGS C+L+ +FLK 
Subjt:  VTLSEGQFQQVSFVNGIATIKGGTHVDYISNQIANYVMNAVNKKNKNANVKAHNVKNYLWVFINALIDNPAFDSQTKETLTIRQNSFGSACDLTPEFLKN

Query:  VATKSGIMDSVLSWVNFKQSKDLKKTDGTKTEKINGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASNKQI
        V  KSG+++++LSW +FKQ+KDLKK+DG KT ++  +EKL+DA  AGGKNS  CTLILTEGDSAK+LA+AG  V+G ++ GVFPLRGKLLNVREAS  QI
Subjt:  VATKSGIMDSVLSWVNFKQSKDLKKTDGTKTEKINGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASNKQI

Query:  MENKEIQYIKQILGLQQGKEYNNAKALRYGHLMIMTDQDHDGSHIKGLLINFVHSFWPSLLRVPSFLVEFITPIVKATHKNGT--VLSFYTMPEYESWKE
          NKEI+ +K+ILGL+Q  +Y N  +LRYG +MIMTDQDHDGSHIKGLLINF+HSFWPSLL+VPSFLVEFITPIVKAT K GT  VLSFY+MPEYE WKE
Subjt:  MENKEIQYIKQILGLQQGKEYNNAKALRYGHLMIMTDQDHDGSHIKGLLINFVHSFWPSLLRVPSFLVEFITPIVKATHKNGT--VLSFYTMPEYESWKE

Query:  SLRNNASGWSIKYYKGLGTSTSKEGREYFEQLAKHKKDFIWQDDNDGEAIELAFSKKKIEERKNWLRQFEPGTHLDQTGKLIKYSDFVNKELILFSMADL
        SL+ NA+GW IKYYKGLGTST++EG+EYF  L  HKKDF+W+D+ DGEAIELAFSKKKIE RKNWL  + PG HLDQ    + YSDFVNKELILFSMADL
Subjt:  SLRNNASGWSIKYYKGLGTSTSKEGREYFEQLAKHKKDFIWQDDNDGEAIELAFSKKKIEERKNWLRQFEPGTHLDQTGKLIKYSDFVNKELILFSMADL

Query:  QRSIPSMVDGLKPGQRKILFCSFKRNFIKEAKISQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLS
        QRSIPSMVDGLKPGQRKILF +FK+   KE K++Q  GYVS  SAYHHGEQSLAS IIGMAQD+VGSNNINLLLPNGQFGTR  GGKD AS+RYI+TKLS
Subjt:  QRSIPSMVDGLKPGQRKILFCSFKRNFIKEAKISQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLS

Query:  NVTRFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDIIRNVRRMLNSETLLPMDPWYRGFSGTIEKTATKEGGSSY
         VTR LFPKDDD LL+YLNEDGQ IEPTWYMPIIPTVLVNG+EGIGTGWS+++PNYNPR+I+ NVRR+LN E+++PMDPWYRGF GTIEKTA+KEGG +Y
Subjt:  NVTRFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDIIRNVRRMLNSETLLPMDPWYRGFSGTIEKTATKEGGSSY

Query:  TVSGIIEEVSDTTLRVIELPVRKWTNDYKEFLDSVTRTYKNDKDKDKVAKEPFIEQADHHSDDKIVSIDVHLTEENMILAMQEGLMKKLKLTTTISTSNM
        T++G+ EEV +TT+R+ ELP+R+W +DYK FL S+    K D         PF +    ++D+K V  D+ L+EENM+ A QEG +KK KLTTTI+TSNM
Subjt:  TVSGIIEEVSDTTLRVIELPVRKWTNDYKEFLDSVTRTYKNDKDKDKVAKEPFIEQADHHSDDKIVSIDVHLTEENMILAMQEGLMKKLKLTTTISTSNM

Query:  HLFDANGVIKKYDTPEQILEEFFPLRLEYYEKRKRNLLENLEMELLKLENKVRFILAVVNGEIIVSNRRRVDLFHELQAKGFTPFPKKAKSVEPEVAGAS
        HLFD  GVIKKY TPEQILEEFF LR EYYEKRK  +++N+E+ELLKLENK RFILAV++GEIIV+ R++ D+  +L+ KGFTPFP+KA+SVE  +AGA 
Subjt:  HLFDANGVIKKYDTPEQILEEFFPLRLEYYEKRKRNLLENLEMELLKLENKVRFILAVVNGEIIVSNRRRVDLFHELQAKGFTPFPKKAKSVEPEVAGAS

Query:  NETDEAEE------SPEVKGERV--SDYEYLLALAIGNLTIEKVQELCNNRDKLKGEVEDLRKATPKSLWLCDLDSLEKELDEMDRADANAE---EVRKQ
        ++ D AEE       PE     +  S+Y+YLLA+AI +LTIEKV+EL  +RDK+   V D++K TPKSLWL DL+SL+KEL+++D  DA  +   E  ++
Subjt:  NETDEAEE------SPEVKGERV--SDYEYLLALAIGNLTIEKVQELCNNRDKLKGEVEDLRKATPKSLWLCDLDSLEKELDEMDRADANAE---EVRKQ

Query:  QRKSNNDIKPKISRNVPKAP---RNNKKTSNSET-----------------------------VTESMDTTSSSSTMEVASNA--VVKPKGKAAAPRKAP
        + ++ +    K+ R  PK P   +  KK S SET                              +ES  T +S S M+  +N   VVKPKG+  A +KAP
Subjt:  QRKSNNDIKPKISRNVPKAP---RNNKKTSNSET-----------------------------VTESMDTTSSSSTMEVASNA--VVKPKGKAAAPRKAP

Query:  AKKGKGPVVNDDAKD-DDEEVLELKDRLAAYKIDSSPDRSEAMETEVPQVQAAKKKEPTKRAPAKKKTTAKSVHISDNDTDDDNFEIKEVRPPAAKKGGG
        A           AK+ +++E+L+L  RLA Y   S+P  S                       +K   T+K++ + D+D D     + EV P   KK  G
Subjt:  AKKGKGPVVNDDAKD-DDEEVLELKDRLAAYKIDSSPDRSEAMETEVPQVQAAKKKEPTKRAPAKKKTTAKSVHISDNDTDDDNFEIKEVRPPAAKKGGG

Query:  GRKTAANANTTKKREPAA--KLGQKLI--TQMLSPAENTGISPEKKVRKIRASPFNKKSGSILGRTGIEEEEEEEEEEDGNEGKIMGSGSSETTEESAGV
        GRK AA   T   + PAA  K G++ +  T++L+     G+SPEKKVRK+R+SPFNKKS S++ R    +EEE  E   GN           ++E+S G 
Subjt:  GRKTAANANTTKKREPAA--KLGQKLI--TQMLSPAENTGISPEKKVRKIRASPFNKKSGSILGRTGIEEEEEEEEEEDGNEGKIMGSGSSETTEESAGV

Query:  APARGRSQRGNRTQVRYVISDSESEPEAVDSDFDDKDADFDED
          A  R QR NR ++ YV+SDSESE  A DS+FDD + D D++
Subjt:  APARGRSQRGNRTQVRYVISDSESEPEAVDSDFDDKDADFDED

AT3G23890.2 topoisomerase II

0.0e+00

63.4

Show/hide

Query:  KRPLQNSNAANVDQLPAGPK-----KTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMD
        K PLQNSNAANV + PA  +     KTIEEMYQKK+QLEHILLRPDTY+GSIEKHTQ LWVYE D+MV R VTYVPGLYKIFDEILVNAADNKQRD  MD
Subjt:  KRPLQNSNAANVDQLPAGPK-----KTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMD

Query:  SLKVVIDAEQNCISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDAEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFSDNMGKKSE
        S++VVID EQN ISV N+G GVPVE+HQEE +YVPE+IFGHLLTSSNYDD  KKTTGGRNGYGAKLTNIFSTEF+IETADGKRLKKYKQVF +NMGKKSE
Subjt:  SLKVVIDAEQNCISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDAEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFSDNMGKKSE

Query:  PIIAKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASAFSSEPP-KRYHVKPNERWEIV
        P+I KC + +NWTKVTFKPDL KFNMT LEDDVVALM KRV D+AGCLGK+VKVELNG+++PVKSF DYVDLYL +A+   +E P  R   K N+RWE+ 
Subjt:  PIIAKCKEGDNWTKVTFKPDLAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASAFSSEPP-KRYHVKPNERWEIV

Query:  VTLSEGQFQQVSFVNGIATIKGGTHVDYISNQIANYVMNAVNKKNKNANVKAHNVKNYLWVFINALIDNPAFDSQTKETLTIRQNSFGSACDLTPEFLKN
        V+LSEGQFQQVSFVN IATIKGGTHVDY+++QI N+++ AVNKKNKNANVKAHNVKN+LWVF+NALIDNPAFDSQTKETLT+RQ+SFGS C+L+ +FLK 
Subjt:  VTLSEGQFQQVSFVNGIATIKGGTHVDYISNQIANYVMNAVNKKNKNANVKAHNVKNYLWVFINALIDNPAFDSQTKETLTIRQNSFGSACDLTPEFLKN

Query:  VATKSGIMDSVLSWVNFKQSKDLKKTDGTKTEKINGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASNKQI
        V  KSG+++++LSW +FKQ+KDLKK+DG KT ++  +EKL+DA  AGGKNS  CTLILTEGDSAK+LA+AG  V+G ++ GVFPLRGKLLNVREAS  QI
Subjt:  VATKSGIMDSVLSWVNFKQSKDLKKTDGTKTEKINGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASNKQI

Query:  MENKEIQYIKQILGLQQGKEYNNAKALRYGHLMIMTDQDHDGSHIKGLLINFVHSFWPSLLRVPSFLVEFITPIVKATHKNGT--VLSFYTMPEYESWKE
          NKEI+ +K+ILGL+Q  +Y N  +LRYG +MIMTDQDHDGSHIKGLLINF+HSFWPSLL+VPSFLVEFITPIVKAT K GT  VLSFY+MPEYE WKE
Subjt:  MENKEIQYIKQILGLQQGKEYNNAKALRYGHLMIMTDQDHDGSHIKGLLINFVHSFWPSLLRVPSFLVEFITPIVKATHKNGT--VLSFYTMPEYESWKE

Query:  SLRNNASGWSIKYYKGLGTSTSKEGREYFEQLAKHKKDFIWQDDNDGEAIELAFSKKKIEERKNWLRQFEPGTHLDQTGKLIKYSDFVNKELILFSMADL
        SL+ NA+GW IKYYKGLGTST++EG+EYF  L  HKKDF+W+D+ DGEAIELAFSKKKIE RKNWL  + PG HLDQ    + YSDFVNKELILFSMADL
Subjt:  SLRNNASGWSIKYYKGLGTSTSKEGREYFEQLAKHKKDFIWQDDNDGEAIELAFSKKKIEERKNWLRQFEPGTHLDQTGKLIKYSDFVNKELILFSMADL

Query:  QRSIPSMVDGLKPGQRKILFCSFKRNFIKEAKISQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLS
        QRSIPSMVDGLKPGQRKILF +FK+   KE K++Q  GYVS  SAYHHGEQSLAS IIGMAQD+VGSNNINLLLPNGQFGTR  GGKD AS+RYI+TKLS
Subjt:  QRSIPSMVDGLKPGQRKILFCSFKRNFIKEAKISQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRNHGGKDHASSRYIYTKLS

Query:  NVTRFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDIIRNVRRMLNSETLLPMDPWYRGFSGTIEKTATKEGGSSY
         VTR LFPKDDD LL+YLNEDGQ IEPTWYMPIIPTVLVNG+EGIGTGWS+++PNYNPR+I+ NVRR+LN E+++PMDPWYRGF GTIEKTA+KEGG +Y
Subjt:  NVTRFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDIIRNVRRMLNSETLLPMDPWYRGFSGTIEKTATKEGGSSY

Query:  TVSGIIEEVSDTTLRVIELPVRKWTNDYKEFLDSVTRTYKNDKDKDKVAKEPFIEQADHHSDDKIVSIDVHLTEENMILAMQEGLMKKLKLTTTISTSNM
        T++G+ EEV +TT+R+ ELP+R+W +DYK FL S+    K D         PF +    ++D+K V  D+ L+EENM+ A QEG +KK KLTTTI+TSNM
Subjt:  TVSGIIEEVSDTTLRVIELPVRKWTNDYKEFLDSVTRTYKNDKDKDKVAKEPFIEQADHHSDDKIVSIDVHLTEENMILAMQEGLMKKLKLTTTISTSNM

Query:  HLFDANGVIKKYDTPEQILEEFFPLRLEYYEKRKRNLLENLEMELLKLENKVRFILAVVNGEIIVSNRRRVDLFHELQAKGFTPFPKKAKSVEPEVAGAS
        HLFD  GVIKKY TPEQILEEFF LR EYYEKRK  +++N+E+ELLKLENK RFILAV++GEIIV+ R++ D+  +L+ KGFTPFP+KA+SVE  +AGA 
Subjt:  HLFDANGVIKKYDTPEQILEEFFPLRLEYYEKRKRNLLENLEMELLKLENKVRFILAVVNGEIIVSNRRRVDLFHELQAKGFTPFPKKAKSVEPEVAGAS

Query:  NETDEAEE------SPEVKGERV--SDYEYLLALAIGNLTIEKVQELCNNRDKLKGEVEDLRKATPKSLWLCDLDSLEKELDEMDRADANAE---EVRKQ
        ++ D AEE       PE     +  S+Y+YLLA+AI +LTIEKV+EL  +RDK+   V D++K TPKSLWL DL+SL+KEL+++D  DA  +   E  ++
Subjt:  NETDEAEE------SPEVKGERV--SDYEYLLALAIGNLTIEKVQELCNNRDKLKGEVEDLRKATPKSLWLCDLDSLEKELDEMDRADANAE---EVRKQ

Query:  QRKSNNDIKPKISRNVPKAPRNNKKTSNSETVTESMDTTSSSSTMEVASNA--VVKPKGKAAAPRKAPAKKGKGPVVNDDAKD-DDEEVLELKDRLAAYK
        + ++ +    K+ R  PK P   K T  +   +ES  T +S S M+  +N   VVKPKG+  A +KAPA           AK+ +++E+L+L  RLA Y 
Subjt:  QRKSNNDIKPKISRNVPKAPRNNKKTSNSETVTESMDTTSSSSTMEVASNA--VVKPKGKAAAPRKAPAKKGKGPVVNDDAKD-DDEEVLELKDRLAAYK

Query:  IDSSPDRSEAMETEVPQVQAAKKKEPTKRAPAKKKTTAKSVHISDNDTDDDNFEIKEVRPPAAKKGGGGRKTAANANTTKKREPAA--KLGQKLI--TQM
          S+P  S                       +K   T+K++ + D+D D     + EV P   KK  GGRK AA   T   + PAA  K G++ +  T++
Subjt:  IDSSPDRSEAMETEVPQVQAAKKKEPTKRAPAKKKTTAKSVHISDNDTDDDNFEIKEVRPPAAKKGGGGRKTAANANTTKKREPAA--KLGQKLI--TQM

Query:  LSPAENTGISPEKKVRKIRASPFNKKSGSILGRTGIEEEEEEEEEEDGNEGKIMGSGSSETTEESAGVAPARGRSQRGNRTQVRYVISDSESEPEAVDSD
        L+     G+SPEKKVRK+R+SPFNKKS S++ R    +EEE  E   GN           ++E+S G   A  R QR NR ++ YV+SDSESE  A DS+
Subjt:  LSPAENTGISPEKKVRKIRASPFNKKSGSILGRTGIEEEEEEEEEEDGNEGKIMGSGSSETTEESAGVAPARGRSQRGNRTQVRYVISDSESEPEAVDSD

Query:  FDDKDADFDED
        FDD + D D++
Subjt:  FDDKDADFDED

AT5G04130.1 DNA GYRASE B2

1.4e-26

24.43

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Query:  EMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMDSLKVVIDAEQNCISVFNNGDGVPVEVHQE
        E  Q    L+ +  RP  Y+GS                     T   GL+ +  EIL NA D  Q   +   + VV+ A+   +SV +NG G+P ++H  
Subjt:  EMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMDSLKVVIDAEQNCISVFNNGDGVPVEVHQE

Query:  EKVYVPELIFGHLLTSSNYDDAEK--KTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFSDNMGKKSEPIIAKC----KEGDNWTKVTFKPDLAK
         K    E +   L     +         +GG +G G  + N  S    +E +  +   ++KQ +S   GK    +  +      +G   T + F PD   
Subjt:  EKVYVPELIFGHLLTSSNYDDAEK--KTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFSDNMGKKSEPIIAKC----KEGDNWTKVTFKPDLAK

Query:  FNMTHLEDDVVALMKKRVLDLAGCLGK-TVKVELNGQRVPVKSFQDYVDL-YLKSASAFSSEPPKRYHVKPNERWEIVVTLSEGQFQ---------QVSF
        F  T +E D   +   R+ +LA    K T+ ++          + +Y     L    ++ +      H     R EI     +   Q          + +
Subjt:  FNMTHLEDDVVALMKKRVLDLAGCLGK-TVKVELNGQRVPVKSFQDYVDL-YLKSASAFSSEPPKRYHVKPNERWEIVVTLSEGQFQ---------QVSF

Query:  VNGIATIKGGTHVDYISNQIANYVMNAVNK----KNKNANVKAHNVKNYLWVFINALIDNPAFDSQTKETL---TIR-------QNSFGSACDLTPEFLK
         N I TI GGTH++ +   +   +     K    K K+ ++   +V+  L   ++  + NP F+ QTK  L    +R       Q       +L P+ L+
Subjt:  VNGIATIKGGTHVDYISNQIANYVMNAVNK----KNKNANVKAHNVKNYLWVFINALIDNPAFDSQTKETL---TIR-------QNSFGSACDLTPEFLK

Query:  NVATKSGIMDSVLSWVNFKQSKDLKKTDGT-KTEKINGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASNK
        ++ +KS  +++  + +  K++++L ++    K+  + G  KL D +    + SE   + + EGDSA   A  G     R F  + PLRGK+LN+      
Subjt:  NVATKSGIMDSVLSWVNFKQSKDLKKTDGT-KTEKINGIEKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASNK

Query:  QIMENKEIQYIKQILGLQQGKEYNNAKALRYGHLMIMTDQDHDGSHIKGLLINFVHSFWPSLLRVPSFLVEFITPIVKATHKNGTVLSFYTMPEYESWKE
         + +N+EIQ +   LGL    E    + LRY  ++I+TD D DG+HI+ LL+ F   +  +L       V  + P+ K   +       Y   + +    
Subjt:  QIMENKEIQYIKQILGLQQGKEYNNAKALRYGHLMIMTDQDHDGSHIKGLLINFVHSFWPSLLRVPSFLVEFITPIVKATHKNGTVLSFYTMPEYESWKE

Query:  SLRNNASGWSIKYYKGLG
        +   NAS ++I+ +KGLG
Subjt:  SLRNNASGWSIKYYKGLG

AT5G53960.1 ATP binding;DNA binding;DNA topoisomerase (ATP-hydrolyzing)s

2.0e-04

29.91

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Query:  ENLEMELLKLENKVRFILAVVNGEIIVSNRRRVDLFHELQAKGFTPFPKKAKSVEPEVAGASNETDEAEESPEVKGERVSDYEYLLALAIGNLTIEKVQE
        +++E +L+KLENK R+I  V +  I + +  R  L   L+ +GFTPFP                   +E+ P       S Y+YL       L I+K +E
Subjt:  ENLEMELLKLENKVRFILAVVNGEIIVSNRRRVDLFHELQAKGFTPFPKKAKSVEPEVAGASNETDEAEESPEVKGERVSDYEYLLALAIGNLTIEKVQE

Query:  LCNNRDKLKGEVEDLRK
        LC+ ++ L+  V  L++
Subjt:  LCNNRDKLKGEVEDLRK

Sequences

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CDS sequence

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ATGGCCGTCGAGAAGAAGCGCCCGCTGCAGAACAGCAACGCCGCCAATGTCGACCAGCTTCCGGCAGGCCCGAAGAAGACGATCGAAGAAATGTACCAGAAGAAGACTCA
GCTCGAGCACATTCTCCTCCGCCCCGATACCTATGTCGGGTCCATCGAAAAGCACACTCAGAACCTCTGGGTTTACGAGAACGACAAGATGGTGCACCGATCCGTCACCT
ATGTGCCGGGTCTTTACAAGATCTTTGATGAAATTTTGGTCAACGCTGCCGATAACAAGCAGAGAGATCCTTCGATGGACTCGCTCAAGGTTGTCATCGATGCTGAACAG
AACTGTATCAGCGTGTTCAACAATGGAGATGGAGTTCCGGTTGAGGTTCATCAGGAAGAGAAGGTTTATGTGCCGGAGTTGATCTTTGGGCATCTGTTGACGAGTAGTAA
CTATGATGATGCTGAGAAGAAAACTACGGGTGGACGAAATGGCTACGGTGCGAAACTTACAAATATCTTTTCGACTGAATTTGTGATCGAGACGGCTGATGGAAAACGCT
TGAAGAAGTATAAGCAGGTATTCTCTGATAACATGGGAAAGAAATCAGAGCCGATCATAGCAAAGTGCAAGGAGGGTGACAATTGGACTAAAGTGACCTTTAAGCCAGAC
TTGGCCAAGTTTAACATGACTCATCTTGAAGATGATGTTGTTGCGTTGATGAAGAAGAGGGTGTTGGATTTGGCCGGATGCCTTGGAAAGACCGTGAAGGTTGAGTTAAA
TGGACAGAGGGTCCCTGTTAAATCGTTTCAAGATTATGTAGATCTCTACCTCAAATCTGCCTCTGCATTCTCAAGTGAACCTCCGAAAAGGTATCACGTTAAGCCTAATG
AGCGATGGGAAATTGTGGTGACCTTGAGTGAGGGGCAGTTCCAGCAGGTCAGCTTTGTGAATGGGATTGCAACTATAAAGGGTGGAACTCATGTTGATTACATTAGTAAT
CAAATAGCAAATTATGTGATGAATGCTGTAAATAAGAAGAACAAAAACGCTAACGTGAAGGCCCACAATGTGAAGAATTATTTGTGGGTTTTTATCAACGCTCTCATTGA
TAATCCTGCCTTCGACTCCCAAACCAAAGAAACTTTGACCATTCGTCAAAACAGTTTCGGCTCTGCATGTGATCTTACGCCAGAGTTTTTGAAGAATGTGGCTACAAAAT
CTGGAATTATGGACAGCGTTCTCTCGTGGGTTAATTTCAAGCAAAGCAAAGATTTGAAGAAAACTGATGGAACAAAGACAGAAAAGATTAATGGCATTGAAAAGTTGGAG
GATGCCAATTGTGCTGGAGGGAAAAACTCAGAAAAATGCACCTTGATTTTGACAGAAGGAGATTCAGCCAAGGCCCTTGCAATGGCTGGACTCGGTGTAGTTGGACGAGA
TTTCTATGGTGTATTCCCGTTGAGAGGTAAATTGCTCAATGTGAGGGAAGCAAGTAACAAACAGATCATGGAGAACAAAGAAATTCAGTACATCAAGCAAATTCTAGGAC
TTCAGCAAGGGAAGGAGTACAATAATGCCAAGGCTTTGAGATATGGTCATTTGATGATTATGACTGATCAGGATCATGATGGTTCGCACATTAAGGGACTCTTGATTAAC
TTTGTTCATTCTTTTTGGCCTTCCCTCTTAAGAGTGCCATCTTTCTTGGTTGAGTTCATAACGCCTATTGTCAAGGCTACTCACAAGAATGGGACTGTGTTATCATTCTA
TACCATGCCCGAGTACGAGTCTTGGAAAGAGAGCTTGAGGAACAATGCAAGTGGTTGGTCAATCAAGTACTATAAGGGGTTGGGAACAAGCACATCCAAAGAAGGAAGGG
AGTACTTTGAACAACTGGCAAAGCACAAGAAAGATTTTATTTGGCAAGATGATAATGATGGAGAGGCCATTGAACTTGCCTTTAGTAAGAAGAAGATTGAAGAGAGGAAG
AATTGGCTCCGTCAATTTGAGCCTGGTACTCATCTGGATCAGACAGGAAAATTGATAAAATACAGTGACTTTGTCAACAAGGAGCTTATATTGTTTTCAATGGCTGATTT
ACAAAGGTCTATCCCTTCAATGGTTGATGGCCTCAAGCCTGGCCAGAGGAAGATCCTTTTCTGTTCTTTCAAGAGGAACTTCATTAAAGAAGCCAAAATTTCTCAATTTT
CCGGTTACGTATCCGAGCATTCTGCTTATCATCATGGTGAGCAGAGTCTTGCTAGCACCATCATTGGAATGGCACAAGACTTTGTCGGCAGTAACAACATTAATCTTCTT
TTGCCGAATGGACAGTTTGGCACTCGAAACCATGGAGGCAAAGATCATGCAAGTTCTAGGTACATTTACACCAAGCTTTCCAATGTTACACGGTTCCTTTTCCCGAAAGA
TGACGACAAGCTTCTTAACTACTTAAATGAAGACGGCCAATCGATCGAACCAACCTGGTATATGCCTATCATACCGACGGTTCTCGTAAACGGTAGTGAAGGAATTGGAA
CCGGGTGGAGTTCGTATGTTCCAAATTATAATCCTAGAGACATCATTAGAAACGTAAGACGCATGTTAAACAGTGAAACATTGTTGCCAATGGATCCTTGGTATAGAGGT
TTTTCAGGAACCATAGAGAAAACTGCCACTAAAGAAGGAGGCAGTAGTTACACTGTTAGTGGAATTATAGAGGAAGTTAGTGACACGACATTGAGAGTAATTGAACTACC
AGTTCGCAAATGGACTAATGATTATAAGGAATTCCTTGATTCTGTCACGAGGACATACAAGAATGACAAAGACAAAGATAAAGTAGCCAAGGAACCGTTTATTGAGCAAG
CTGATCACCACAGCGATGACAAAATTGTTTCCATTGATGTTCACTTGACGGAGGAAAACATGATACTAGCCATGCAGGAGGGTTTGATGAAGAAACTCAAATTAACTACT
ACTATCAGCACAAGCAACATGCATCTGTTTGATGCAAATGGGGTGATTAAGAAATATGATACTCCAGAACAAATTCTGGAGGAATTTTTTCCCCTTAGACTTGAATATTA
TGAGAAAAGAAAGAGAAATCTTTTGGAGAACCTTGAAATGGAGTTGCTCAAACTAGAGAACAAGGTGAGGTTTATCCTTGCTGTTGTGAATGGAGAGATAATAGTAAGCA
ATAGAAGAAGAGTTGATTTGTTCCATGAGCTTCAAGCGAAAGGTTTTACACCCTTTCCAAAGAAGGCCAAATCGGTTGAACCGGAGGTTGCTGGAGCATCTAATGAAACA
GATGAAGCAGAGGAGAGTCCAGAAGTAAAAGGGGAACGGGTCAGCGATTACGAGTATCTATTGGCTCTAGCAATTGGAAACTTGACTATTGAGAAGGTTCAGGAGCTATG
CAATAATAGAGACAAGCTCAAAGGGGAAGTGGAAGATCTGAGGAAGGCAACCCCCAAGTCTCTGTGGCTGTGTGATCTTGATTCTCTTGAGAAGGAGCTTGATGAGATGG
ATAGAGCTGATGCCAATGCAGAGGAGGTAAGAAAACAGCAAAGAAAATCAAATAATGATATAAAGCCAAAGATCTCTAGGAATGTTCCTAAAGCTCCACGGAACAATAAG
AAAACTAGCAATTCAGAAACTGTCACAGAAAGTATGGACACAACATCTAGTTCTTCAACAATGGAAGTTGCAAGTAACGCGGTGGTGAAGCCTAAAGGCAAAGCAGCAGC
TCCAAGAAAAGCTCCTGCTAAGAAGGGTAAAGGTCCAGTTGTCAACGATGATGCCAAAGATGACGACGAAGAAGTGCTTGAGCTTAAAGATCGTCTTGCTGCCTACAAAA
TCGATTCATCTCCTGATCGGTCGGAAGCCATGGAAACAGAAGTACCACAAGTACAGGCAGCCAAGAAGAAAGAACCCACCAAGAGAGCACCCGCCAAGAAGAAAACCACT
GCAAAATCTGTTCATATTTCCGATAACGACACCGACGACGATAACTTCGAAATAAAGGAGGTACGTCCTCCAGCAGCCAAGAAGGGAGGAGGAGGAAGAAAAACAGCTGC
AAATGCCAACACGACCAAGAAGCGAGAACCGGCTGCAAAATTAGGACAGAAACTGATAACCCAAATGCTGTCGCCGGCGGAGAACACTGGCATCTCGCCAGAGAAGAAGG
TGAGAAAGATCAGAGCATCCCCATTCAACAAGAAAAGTGGCTCTATATTGGGAAGAACTGGAATTGAAGAAGAAGAAGAAGAAGAAGAAGAAGAAGATGGAAATGAAGGG
AAGATAATGGGGTCTGGTTCTTCTGAGACGACTGAAGAATCCGCCGGAGTTGCGCCGGCGAGAGGAAGATCACAGAGAGGGAACAGAACTCAGGTAAGATATGTGATTAG
TGATTCAGAGAGTGAGCCTGAAGCTGTTGATTCTGACTTTGATGATAAAGATGCTGACTTTGATGAAGATTGA

mRNA sequence

Show/hide mRNA sequence

ACCATCTCTGTGTCTTTCTTTTCTCTCTCTTCCACTTTCTCTCTCAAGAAATCTGTTTCCCGATCGCCATGGCCGTCGAGAAGAAGCGCCCGCTGCAGAACAGCAACGCC
GCCAATGTCGACCAGCTTCCGGCAGGCCCGAAGAAGACGATCGAAGAAATGTACCAGAAGAAGACTCAGCTCGAGCACATTCTCCTCCGCCCCGATACCTATGTCGGGTC
CATCGAAAAGCACACTCAGAACCTCTGGGTTTACGAGAACGACAAGATGGTGCACCGATCCGTCACCTATGTGCCGGGTCTTTACAAGATCTTTGATGAAATTTTGGTCA
ACGCTGCCGATAACAAGCAGAGAGATCCTTCGATGGACTCGCTCAAGGTTGTCATCGATGCTGAACAGAACTGTATCAGCGTGTTCAACAATGGAGATGGAGTTCCGGTT
GAGGTTCATCAGGAAGAGAAGGTTTATGTGCCGGAGTTGATCTTTGGGCATCTGTTGACGAGTAGTAACTATGATGATGCTGAGAAGAAAACTACGGGTGGACGAAATGG
CTACGGTGCGAAACTTACAAATATCTTTTCGACTGAATTTGTGATCGAGACGGCTGATGGAAAACGCTTGAAGAAGTATAAGCAGGTATTCTCTGATAACATGGGAAAGA
AATCAGAGCCGATCATAGCAAAGTGCAAGGAGGGTGACAATTGGACTAAAGTGACCTTTAAGCCAGACTTGGCCAAGTTTAACATGACTCATCTTGAAGATGATGTTGTT
GCGTTGATGAAGAAGAGGGTGTTGGATTTGGCCGGATGCCTTGGAAAGACCGTGAAGGTTGAGTTAAATGGACAGAGGGTCCCTGTTAAATCGTTTCAAGATTATGTAGA
TCTCTACCTCAAATCTGCCTCTGCATTCTCAAGTGAACCTCCGAAAAGGTATCACGTTAAGCCTAATGAGCGATGGGAAATTGTGGTGACCTTGAGTGAGGGGCAGTTCC
AGCAGGTCAGCTTTGTGAATGGGATTGCAACTATAAAGGGTGGAACTCATGTTGATTACATTAGTAATCAAATAGCAAATTATGTGATGAATGCTGTAAATAAGAAGAAC
AAAAACGCTAACGTGAAGGCCCACAATGTGAAGAATTATTTGTGGGTTTTTATCAACGCTCTCATTGATAATCCTGCCTTCGACTCCCAAACCAAAGAAACTTTGACCAT
TCGTCAAAACAGTTTCGGCTCTGCATGTGATCTTACGCCAGAGTTTTTGAAGAATGTGGCTACAAAATCTGGAATTATGGACAGCGTTCTCTCGTGGGTTAATTTCAAGC
AAAGCAAAGATTTGAAGAAAACTGATGGAACAAAGACAGAAAAGATTAATGGCATTGAAAAGTTGGAGGATGCCAATTGTGCTGGAGGGAAAAACTCAGAAAAATGCACC
TTGATTTTGACAGAAGGAGATTCAGCCAAGGCCCTTGCAATGGCTGGACTCGGTGTAGTTGGACGAGATTTCTATGGTGTATTCCCGTTGAGAGGTAAATTGCTCAATGT
GAGGGAAGCAAGTAACAAACAGATCATGGAGAACAAAGAAATTCAGTACATCAAGCAAATTCTAGGACTTCAGCAAGGGAAGGAGTACAATAATGCCAAGGCTTTGAGAT
ATGGTCATTTGATGATTATGACTGATCAGGATCATGATGGTTCGCACATTAAGGGACTCTTGATTAACTTTGTTCATTCTTTTTGGCCTTCCCTCTTAAGAGTGCCATCT
TTCTTGGTTGAGTTCATAACGCCTATTGTCAAGGCTACTCACAAGAATGGGACTGTGTTATCATTCTATACCATGCCCGAGTACGAGTCTTGGAAAGAGAGCTTGAGGAA
CAATGCAAGTGGTTGGTCAATCAAGTACTATAAGGGGTTGGGAACAAGCACATCCAAAGAAGGAAGGGAGTACTTTGAACAACTGGCAAAGCACAAGAAAGATTTTATTT
GGCAAGATGATAATGATGGAGAGGCCATTGAACTTGCCTTTAGTAAGAAGAAGATTGAAGAGAGGAAGAATTGGCTCCGTCAATTTGAGCCTGGTACTCATCTGGATCAG
ACAGGAAAATTGATAAAATACAGTGACTTTGTCAACAAGGAGCTTATATTGTTTTCAATGGCTGATTTACAAAGGTCTATCCCTTCAATGGTTGATGGCCTCAAGCCTGG
CCAGAGGAAGATCCTTTTCTGTTCTTTCAAGAGGAACTTCATTAAAGAAGCCAAAATTTCTCAATTTTCCGGTTACGTATCCGAGCATTCTGCTTATCATCATGGTGAGC
AGAGTCTTGCTAGCACCATCATTGGAATGGCACAAGACTTTGTCGGCAGTAACAACATTAATCTTCTTTTGCCGAATGGACAGTTTGGCACTCGAAACCATGGAGGCAAA
GATCATGCAAGTTCTAGGTACATTTACACCAAGCTTTCCAATGTTACACGGTTCCTTTTCCCGAAAGATGACGACAAGCTTCTTAACTACTTAAATGAAGACGGCCAATC
GATCGAACCAACCTGGTATATGCCTATCATACCGACGGTTCTCGTAAACGGTAGTGAAGGAATTGGAACCGGGTGGAGTTCGTATGTTCCAAATTATAATCCTAGAGACA
TCATTAGAAACGTAAGACGCATGTTAAACAGTGAAACATTGTTGCCAATGGATCCTTGGTATAGAGGTTTTTCAGGAACCATAGAGAAAACTGCCACTAAAGAAGGAGGC
AGTAGTTACACTGTTAGTGGAATTATAGAGGAAGTTAGTGACACGACATTGAGAGTAATTGAACTACCAGTTCGCAAATGGACTAATGATTATAAGGAATTCCTTGATTC
TGTCACGAGGACATACAAGAATGACAAAGACAAAGATAAAGTAGCCAAGGAACCGTTTATTGAGCAAGCTGATCACCACAGCGATGACAAAATTGTTTCCATTGATGTTC
ACTTGACGGAGGAAAACATGATACTAGCCATGCAGGAGGGTTTGATGAAGAAACTCAAATTAACTACTACTATCAGCACAAGCAACATGCATCTGTTTGATGCAAATGGG
GTGATTAAGAAATATGATACTCCAGAACAAATTCTGGAGGAATTTTTTCCCCTTAGACTTGAATATTATGAGAAAAGAAAGAGAAATCTTTTGGAGAACCTTGAAATGGA
GTTGCTCAAACTAGAGAACAAGGTGAGGTTTATCCTTGCTGTTGTGAATGGAGAGATAATAGTAAGCAATAGAAGAAGAGTTGATTTGTTCCATGAGCTTCAAGCGAAAG
GTTTTACACCCTTTCCAAAGAAGGCCAAATCGGTTGAACCGGAGGTTGCTGGAGCATCTAATGAAACAGATGAAGCAGAGGAGAGTCCAGAAGTAAAAGGGGAACGGGTC
AGCGATTACGAGTATCTATTGGCTCTAGCAATTGGAAACTTGACTATTGAGAAGGTTCAGGAGCTATGCAATAATAGAGACAAGCTCAAAGGGGAAGTGGAAGATCTGAG
GAAGGCAACCCCCAAGTCTCTGTGGCTGTGTGATCTTGATTCTCTTGAGAAGGAGCTTGATGAGATGGATAGAGCTGATGCCAATGCAGAGGAGGTAAGAAAACAGCAAA
GAAAATCAAATAATGATATAAAGCCAAAGATCTCTAGGAATGTTCCTAAAGCTCCACGGAACAATAAGAAAACTAGCAATTCAGAAACTGTCACAGAAAGTATGGACACA
ACATCTAGTTCTTCAACAATGGAAGTTGCAAGTAACGCGGTGGTGAAGCCTAAAGGCAAAGCAGCAGCTCCAAGAAAAGCTCCTGCTAAGAAGGGTAAAGGTCCAGTTGT
CAACGATGATGCCAAAGATGACGACGAAGAAGTGCTTGAGCTTAAAGATCGTCTTGCTGCCTACAAAATCGATTCATCTCCTGATCGGTCGGAAGCCATGGAAACAGAAG
TACCACAAGTACAGGCAGCCAAGAAGAAAGAACCCACCAAGAGAGCACCCGCCAAGAAGAAAACCACTGCAAAATCTGTTCATATTTCCGATAACGACACCGACGACGAT
AACTTCGAAATAAAGGAGGTACGTCCTCCAGCAGCCAAGAAGGGAGGAGGAGGAAGAAAAACAGCTGCAAATGCCAACACGACCAAGAAGCGAGAACCGGCTGCAAAATT
AGGACAGAAACTGATAACCCAAATGCTGTCGCCGGCGGAGAACACTGGCATCTCGCCAGAGAAGAAGGTGAGAAAGATCAGAGCATCCCCATTCAACAAGAAAAGTGGCT
CTATATTGGGAAGAACTGGAATTGAAGAAGAAGAAGAAGAAGAAGAAGAAGAAGATGGAAATGAAGGGAAGATAATGGGGTCTGGTTCTTCTGAGACGACTGAAGAATCC
GCCGGAGTTGCGCCGGCGAGAGGAAGATCACAGAGAGGGAACAGAACTCAGGTAAGATATGTGATTAGTGATTCAGAGAGTGAGCCTGAAGCTGTTGATTCTGACTTTGA
TGATAAAGATGCTGACTTTGATGAAGATTGAAGAAATGTGCTGATCATTTTCCTGTGAGAAACTGATCTTTCTTCTTCATGGCTTTGTCTGTAATATCTTCGTCTGTAGT
TGTAGAAAAAACCATGTAGAAATTAAGAAGCAAAACTATGCTTATTGTTGTGATGTCACAATTTAATGAAGATTTTGGGCATTTCAATGATTTCAACTTCCA

Protein sequence

Show/hide protein sequence

MAVEKKRPLQNSNAANVDQLPAGPKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMVHRSVTYVPGLYKIFDEILVNAADNKQRDPSMDSLKVVIDAEQ
NCISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDAEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFSDNMGKKSEPIIAKCKEGDNWTKVTFKPD
LAKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVPVKSFQDYVDLYLKSASAFSSEPPKRYHVKPNERWEIVVTLSEGQFQQVSFVNGIATIKGGTHVDYISN
QIANYVMNAVNKKNKNANVKAHNVKNYLWVFINALIDNPAFDSQTKETLTIRQNSFGSACDLTPEFLKNVATKSGIMDSVLSWVNFKQSKDLKKTDGTKTEKINGIEKLE
DANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLRGKLLNVREASNKQIMENKEIQYIKQILGLQQGKEYNNAKALRYGHLMIMTDQDHDGSHIKGLLIN
FVHSFWPSLLRVPSFLVEFITPIVKATHKNGTVLSFYTMPEYESWKESLRNNASGWSIKYYKGLGTSTSKEGREYFEQLAKHKKDFIWQDDNDGEAIELAFSKKKIEERK
NWLRQFEPGTHLDQTGKLIKYSDFVNKELILFSMADLQRSIPSMVDGLKPGQRKILFCSFKRNFIKEAKISQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLL
LPNGQFGTRNHGGKDHASSRYIYTKLSNVTRFLFPKDDDKLLNYLNEDGQSIEPTWYMPIIPTVLVNGSEGIGTGWSSYVPNYNPRDIIRNVRRMLNSETLLPMDPWYRG
FSGTIEKTATKEGGSSYTVSGIIEEVSDTTLRVIELPVRKWTNDYKEFLDSVTRTYKNDKDKDKVAKEPFIEQADHHSDDKIVSIDVHLTEENMILAMQEGLMKKLKLTT
TISTSNMHLFDANGVIKKYDTPEQILEEFFPLRLEYYEKRKRNLLENLEMELLKLENKVRFILAVVNGEIIVSNRRRVDLFHELQAKGFTPFPKKAKSVEPEVAGASNET
DEAEESPEVKGERVSDYEYLLALAIGNLTIEKVQELCNNRDKLKGEVEDLRKATPKSLWLCDLDSLEKELDEMDRADANAEEVRKQQRKSNNDIKPKISRNVPKAPRNNK
KTSNSETVTESMDTTSSSSTMEVASNAVVKPKGKAAAPRKAPAKKGKGPVVNDDAKDDDEEVLELKDRLAAYKIDSSPDRSEAMETEVPQVQAAKKKEPTKRAPAKKKTT
AKSVHISDNDTDDDNFEIKEVRPPAAKKGGGGRKTAANANTTKKREPAAKLGQKLITQMLSPAENTGISPEKKVRKIRASPFNKKSGSILGRTGIEEEEEEEEEEDGNEG
KIMGSGSSETTEESAGVAPARGRSQRGNRTQVRYVISDSESEPEAVDSDFDDKDADFDED

Sed0024297 (gene) of Chayote v1 genome