CuGenDBv2

Gene ID	Sgr017868
Organism	Siraitia grosvenorii cv. Qingpiguo (Monk fruit (Qingpiguo) v1)
Description	DNA topoisomerase
Genome location	tig00153056:831367..844665
RNA-Seq Expression	Sgr017868
Synteny	Sgr017868
Gene Ontology terms	GO:0006265 - DNA topological change (biological process) GO:0005694 - chromosome (cellular component) GO:0003677 - DNA binding (molecular function) GO:0003917 - DNA topoisomerase type I activity (molecular function) GO:0046872 - metal ion binding (molecular function)
InterPro domains	IPR000380 - DNA topoisomerase, type IA IPR003602 - DNA topoisomerase, type IA, DNA-binding domain IPR013497 - DNA topoisomerase, type IA, central IPR013824 - DNA topoisomerase, type IA, central region, subdomain 1 IPR013826 - DNA topoisomerase, type IA, central region, subdomain 3 IPR023405 - DNA topoisomerase, type IA, core domain IPR023406 - DNA topoisomerase, type IA, active site IPR025589 - Topoisomerase C-terminal repeat

Homology

Show/hide homology

GenBank top hits

e value

%identity

Alignment

XP_022144286.1 uncharacterized protein LOC111013976 [Momordica charantia]

2.4e-222

78.88

Show/hide

Query:  LAQKLYEGIQLADGKAAGLITYPRTDGLHISDEAVKDIRSLIIQRYGQNFVSESAPKYFKKVKNAQEAHEAIRPTDMLQLPSMLVGTLDEDSHKLYSLIW
        LAQKLYEGIQLADGKAAGLITYPRTDGLHISDEAVKDIRSLIIQRYGQNFVSESA KYFKKVKNAQEAHEAIRPTD+ QLPSMLVGTLDEDSHKLYSLIW
Subjt:  LAQKLYEGIQLADGKAAGLITYPRTDGLHISDEAVKDIRSLIIQRYGQNFVSESAPKYFKKVKNAQEAHEAIRPTDMLQLPSMLVGTLDEDSHKLYSLIW

Query:  LERWRAKWNPLSLNRGEWVDNASTNS-----QAKGLAKTRGIFSKFKMSGRDTEDKSHPYLKLRLLWLRVGSYIKTGDQLSLGGVELKQHFTQPPPRYSE
        L     +  P S+     +D+   N            + RG    F+    D   +       R    R+ + ++ GDQLSL  VELKQHFTQPPPRYSE
Subjt:  LERWRAKWNPLSLNRGEWVDNASTNS-----QAKGLAKTRGIFSKFKMSGRDTEDKSHPYLKLRLLWLRVGSYIKTGDQLSLGGVELKQHFTQPPPRYSE

Query:  GTLVKRMEELGIGRPSTYATTLKVLQDRNYVSVKSRVLHPEFRGRMVSAFLCHHFSEVTDYSFTADMETELDNVSAGLTEWKGLLRDYWTRFSSYCERAT
        GTLVKRMEELGIGRPSTYATTLKVLQDRNYVSVKSRVLHPEFRGRMVSAFLCHHFSEVTDYSFTADMETELDNVSAGLTEWKGLLRDYWTRFSSYCE A 
Subjt:  GTLVKRMEELGIGRPSTYATTLKVLQDRNYVSVKSRVLHPEFRGRMVSAFLCHHFSEVTDYSFTADMETELDNVSAGLTEWKGLLRDYWTRFSSYCERAT

Query:  NVHIHQVEKMLEKKFGDFLFSFLPDNCRTCP----------------------------RYIAKTLYGEDEEEVTPQNNNSVEEPKLLGLHPVSNEKILL
        +VHIHQVEKMLEKKFGDFLFSFLPDNCRTCP                            +YIAKTLYGED EEVTPQNNNSVEEPKLLGLHPVSNEKILL
Subjt:  NVHIHQVEKMLEKKFGDFLFSFLPDNCRTCP----------------------------RYIAKTLYGEDEEEVTPQNNNSVEEPKLLGLHPVSNEKILL

Query:  KSGPYGFYVQLGEDRKGYLPKRASVSQIKDVDSITLEDALELLRYPITLGNHPKDGQPVIIKIAKAGFSVRHRRTIASVPKNLKPNDINLEKALELLSSK
        KSGPYGFYVQLGEDRKGYLPKRASVSQIK VDSITLEDALELLRYPITLGNHPKDGQPVIIKIAKAGFSVRHRRTIA++PKNLKPN I LEKALELLSS 
Subjt:  KSGPYGFYVQLGEDRKGYLPKRASVSQIKDVDSITLEDALELLRYPITLGNHPKDGQPVIIKIAKAGFSVRHRRTIASVPKNLKPNDINLEKALELLSSK

Query:  DVRRCGRPKSKPKVEE
        DVRRCGRPKSKPKVEE
Subjt:  DVRRCGRPKSKPKVEE

XP_022936881.1 uncharacterized protein LOC111443338 isoform X1 [Cucurbita moschata]

4.6e-218

76.15

Show/hide

Query:  LAQKLYEGIQLADGKAAGLITYPRTDGLHISDEAVKDIRSLIIQRYGQNFVSESAPKYFKKVKNAQEAHEAIRPTDMLQLPSMLVGTLDEDSHKLYSLIW
        LAQKLYEGIQLADGKAAGLITYPRTDGLHISDEAVKDIRSLI QRYG+NFVSESA KYFKKVKNAQEAHEAIRPTD+ +LPSMLVGTLDEDSHKLYSLIW
Subjt:  LAQKLYEGIQLADGKAAGLITYPRTDGLHISDEAVKDIRSLIIQRYGQNFVSESAPKYFKKVKNAQEAHEAIRPTDMLQLPSMLVGTLDEDSHKLYSLIW

Query:  LERWRAKWNPLSLNRGEWVDNASTNSQAKGLAKTRGIFSKFKMSGRDTE-----DKSHPYLKLRLLWLRVGSYIKTGDQLSLGGVELKQHFTQPPPRYSE
        L     +  P    + +     +  S       +R  F  F+    D E      K H   +   L+ R+ + +K+GDQLSL  VELKQHFTQPPPRYSE
Subjt:  LERWRAKWNPLSLNRGEWVDNASTNSQAKGLAKTRGIFSKFKMSGRDTE-----DKSHPYLKLRLLWLRVGSYIKTGDQLSLGGVELKQHFTQPPPRYSE

Query:  GTLVKRMEELGIGRPSTYATTLKVLQDRNYVSVKSRVLHPEFRGRMVSAFLCHHFSEVTDYSFTADMETELDNVSAGLTEWKGLLRDYWTRFSSYCERAT
        GTLVK+MEELGIGRPSTYA+TLKVLQDRNY+SVKSRVLHPEFRGRMVSAFLCHHFSEVTDYSFTADME ELDNVSAGLTEWKGLL+DYWTRFS+YCERA 
Subjt:  GTLVKRMEELGIGRPSTYATTLKVLQDRNYVSVKSRVLHPEFRGRMVSAFLCHHFSEVTDYSFTADMETELDNVSAGLTEWKGLLRDYWTRFSSYCERAT

Query:  NVHIHQVEKMLEKKFGDFLFSFLPDNCRTCP----------------------------RYIAKTLYGEDEEEVTPQNNNSVEEPKLLGLHPVSNEKILL
        NVHIHQVEKMLEKK+ DFLFSFLPDNCR+CP                            +YIAKTLYGEDEEEVTPQNN SVEEPKLLGLHPVS+EKILL
Subjt:  NVHIHQVEKMLEKKFGDFLFSFLPDNCRTCP----------------------------RYIAKTLYGEDEEEVTPQNNNSVEEPKLLGLHPVSNEKILL

Query:  KSGPYGFYVQLGEDRKGYLPKRASVSQIKDVDSITLEDALELLRYPITLGNHPKDGQPVIIKIAKAGFSVRHRRTIASVPKNLKPNDINLEKALELLSSK
        KSGPYGFYVQLGEDRKGY+PKR SVSQIKDVDSITLEDALELLRYPITLGNHPKDGQ V+IKI KAGF+VRHRRTIASVPKNLKPND++L KALELLSS+
Subjt:  KSGPYGFYVQLGEDRKGYLPKRASVSQIKDVDSITLEDALELLRYPITLGNHPKDGQPVIIKIAKAGFSVRHRRTIASVPKNLKPNDINLEKALELLSSK

Query:  DVRRCGRPKSKPKVEEAVEA
        DVRRCGRPKSK K EEAVEA
Subjt:  DVRRCGRPKSKPKVEEAVEA

XP_022936882.1 uncharacterized protein LOC111443338 isoform X2 [Cucurbita moschata]

4.6e-218

76.15

Show/hide

Query:  LAQKLYEGIQLADGKAAGLITYPRTDGLHISDEAVKDIRSLIIQRYGQNFVSESAPKYFKKVKNAQEAHEAIRPTDMLQLPSMLVGTLDEDSHKLYSLIW
        LAQKLYEGIQLADGKAAGLITYPRTDGLHISDEAVKDIRSLI QRYG+NFVSESA KYFKKVKNAQEAHEAIRPTD+ +LPSMLVGTLDEDSHKLYSLIW
Subjt:  LAQKLYEGIQLADGKAAGLITYPRTDGLHISDEAVKDIRSLIIQRYGQNFVSESAPKYFKKVKNAQEAHEAIRPTDMLQLPSMLVGTLDEDSHKLYSLIW

Query:  LERWRAKWNPLSLNRGEWVDNASTNSQAKGLAKTRGIFSKFKMSGRDTE-----DKSHPYLKLRLLWLRVGSYIKTGDQLSLGGVELKQHFTQPPPRYSE
        L     +  P    + +     +  S       +R  F  F+    D E      K H   +   L+ R+ + +K+GDQLSL  VELKQHFTQPPPRYSE
Subjt:  LERWRAKWNPLSLNRGEWVDNASTNSQAKGLAKTRGIFSKFKMSGRDTE-----DKSHPYLKLRLLWLRVGSYIKTGDQLSLGGVELKQHFTQPPPRYSE

Query:  GTLVKRMEELGIGRPSTYATTLKVLQDRNYVSVKSRVLHPEFRGRMVSAFLCHHFSEVTDYSFTADMETELDNVSAGLTEWKGLLRDYWTRFSSYCERAT
        GTLVK+MEELGIGRPSTYA+TLKVLQDRNY+SVKSRVLHPEFRGRMVSAFLCHHFSEVTDYSFTADME ELDNVSAGLTEWKGLL+DYWTRFS+YCERA 
Subjt:  GTLVKRMEELGIGRPSTYATTLKVLQDRNYVSVKSRVLHPEFRGRMVSAFLCHHFSEVTDYSFTADMETELDNVSAGLTEWKGLLRDYWTRFSSYCERAT

Query:  NVHIHQVEKMLEKKFGDFLFSFLPDNCRTCP----------------------------RYIAKTLYGEDEEEVTPQNNNSVEEPKLLGLHPVSNEKILL
        NVHIHQVEKMLEKK+ DFLFSFLPDNCR+CP                            +YIAKTLYGEDEEEVTPQNN SVEEPKLLGLHPVS+EKILL
Subjt:  NVHIHQVEKMLEKKFGDFLFSFLPDNCRTCP----------------------------RYIAKTLYGEDEEEVTPQNNNSVEEPKLLGLHPVSNEKILL

Query:  KSGPYGFYVQLGEDRKGYLPKRASVSQIKDVDSITLEDALELLRYPITLGNHPKDGQPVIIKIAKAGFSVRHRRTIASVPKNLKPNDINLEKALELLSSK
        KSGPYGFYVQLGEDRKGY+PKR SVSQIKDVDSITLEDALELLRYPITLGNHPKDGQ V+IKI KAGF+VRHRRTIASVPKNLKPND++L KALELLSS+
Subjt:  KSGPYGFYVQLGEDRKGYLPKRASVSQIKDVDSITLEDALELLRYPITLGNHPKDGQPVIIKIAKAGFSVRHRRTIASVPKNLKPNDINLEKALELLSSK

Query:  DVRRCGRPKSKPKVEEAVEA
        DVRRCGRPKSK K EEAVEA
Subjt:  DVRRCGRPKSKPKVEEAVEA

XP_022976242.1 uncharacterized protein LOC111476696 isoform X1 [Cucurbita maxima]

4.2e-219

76.73

Show/hide

Query:  LAQKLYEGIQLADGKAAGLITYPRTDGLHISDEAVKDIRSLIIQRYGQNFVSESAPKYFKKVKNAQEAHEAIRPTDMLQLPSMLVGTLDEDSHKLYSLIW
        LAQKLYEGIQLADGKAAGLITYPRTDGLHISDEAVKDIRSLI QRYG NFVSESA KYFKKVKNAQEAHEAIRPTD+ +LPSMLVGTLDEDSHKLYSLIW
Subjt:  LAQKLYEGIQLADGKAAGLITYPRTDGLHISDEAVKDIRSLIIQRYGQNFVSESAPKYFKKVKNAQEAHEAIRPTDMLQLPSMLVGTLDEDSHKLYSLIW

Query:  LERWRAKWNPLSLNRGEWVDNASTNSQAKGLAKTRGIFSKFKMSGRDTE-----DKSHPYLKLRLLWLRVGSYIKTGDQLSLGGVELKQHFTQPPPRYSE
        L     +  P    + +     +  S       +R  F  F+    D E      K H   +   L+ R+ + +K+GDQLSL  VELKQHFTQPPPRYSE
Subjt:  LERWRAKWNPLSLNRGEWVDNASTNSQAKGLAKTRGIFSKFKMSGRDTE-----DKSHPYLKLRLLWLRVGSYIKTGDQLSLGGVELKQHFTQPPPRYSE

Query:  GTLVKRMEELGIGRPSTYATTLKVLQDRNYVSVKSRVLHPEFRGRMVSAFLCHHFSEVTDYSFTADMETELDNVSAGLTEWKGLLRDYWTRFSSYCERAT
        GTLVK+MEELGIGRPSTYA+TLKVLQDRNY+SVKSRVLHPEFRGRMVSAFLCHHFSEVTDYSFTADME ELDNVSAGLTEWKGLLRDYWTRFS+YCERA 
Subjt:  GTLVKRMEELGIGRPSTYATTLKVLQDRNYVSVKSRVLHPEFRGRMVSAFLCHHFSEVTDYSFTADMETELDNVSAGLTEWKGLLRDYWTRFSSYCERAT

Query:  NVHIHQVEKMLEKKFGDFLFSFLPDNCRTCP----------------------------RYIAKTLYGEDEEEVTPQNNNSVEEPKLLGLHPVSNEKILL
        NVHIHQVEKMLEKK+ DFLFSFLPDNCRTCP                            +YIAKTLYGEDEEEVTPQNN SVEEPKLLGLHPVS+EKILL
Subjt:  NVHIHQVEKMLEKKFGDFLFSFLPDNCRTCP----------------------------RYIAKTLYGEDEEEVTPQNNNSVEEPKLLGLHPVSNEKILL

Query:  KSGPYGFYVQLGEDRKGYLPKRASVSQIKDVDSITLEDALELLRYPITLGNHPKDGQPVIIKIAKAGFSVRHRRTIASVPKNLKPNDINLEKALELLSSK
        KSGPYGFYVQLGEDRKGY+PKR SVSQIKDV SITLEDALELLRYPITLGNHPKDG  V+IKI KAGF+VRHRRTIASVPKNLKPND++L KALELLSSK
Subjt:  KSGPYGFYVQLGEDRKGYLPKRASVSQIKDVDSITLEDALELLRYPITLGNHPKDGQPVIIKIAKAGFSVRHRRTIASVPKNLKPNDINLEKALELLSSK

Query:  DVRRCGRPKSKPKVEEAVEA
        DVRRCGRPKSKPKVEEAVEA
Subjt:  DVRRCGRPKSKPKVEEAVEA

XP_022976244.1 uncharacterized protein LOC111476696 isoform X2 [Cucurbita maxima]

4.2e-219

76.73

Show/hide

Query:  LAQKLYEGIQLADGKAAGLITYPRTDGLHISDEAVKDIRSLIIQRYGQNFVSESAPKYFKKVKNAQEAHEAIRPTDMLQLPSMLVGTLDEDSHKLYSLIW
        LAQKLYEGIQLADGKAAGLITYPRTDGLHISDEAVKDIRSLI QRYG NFVSESA KYFKKVKNAQEAHEAIRPTD+ +LPSMLVGTLDEDSHKLYSLIW
Subjt:  LAQKLYEGIQLADGKAAGLITYPRTDGLHISDEAVKDIRSLIIQRYGQNFVSESAPKYFKKVKNAQEAHEAIRPTDMLQLPSMLVGTLDEDSHKLYSLIW

Query:  LERWRAKWNPLSLNRGEWVDNASTNSQAKGLAKTRGIFSKFKMSGRDTE-----DKSHPYLKLRLLWLRVGSYIKTGDQLSLGGVELKQHFTQPPPRYSE
        L     +  P    + +     +  S       +R  F  F+    D E      K H   +   L+ R+ + +K+GDQLSL  VELKQHFTQPPPRYSE
Subjt:  LERWRAKWNPLSLNRGEWVDNASTNSQAKGLAKTRGIFSKFKMSGRDTE-----DKSHPYLKLRLLWLRVGSYIKTGDQLSLGGVELKQHFTQPPPRYSE

Query:  GTLVKRMEELGIGRPSTYATTLKVLQDRNYVSVKSRVLHPEFRGRMVSAFLCHHFSEVTDYSFTADMETELDNVSAGLTEWKGLLRDYWTRFSSYCERAT
        GTLVK+MEELGIGRPSTYA+TLKVLQDRNY+SVKSRVLHPEFRGRMVSAFLCHHFSEVTDYSFTADME ELDNVSAGLTEWKGLLRDYWTRFS+YCERA 
Subjt:  GTLVKRMEELGIGRPSTYATTLKVLQDRNYVSVKSRVLHPEFRGRMVSAFLCHHFSEVTDYSFTADMETELDNVSAGLTEWKGLLRDYWTRFSSYCERAT

Query:  NVHIHQVEKMLEKKFGDFLFSFLPDNCRTCP----------------------------RYIAKTLYGEDEEEVTPQNNNSVEEPKLLGLHPVSNEKILL
        NVHIHQVEKMLEKK+ DFLFSFLPDNCRTCP                            +YIAKTLYGEDEEEVTPQNN SVEEPKLLGLHPVS+EKILL
Subjt:  NVHIHQVEKMLEKKFGDFLFSFLPDNCRTCP----------------------------RYIAKTLYGEDEEEVTPQNNNSVEEPKLLGLHPVSNEKILL

Query:  KSGPYGFYVQLGEDRKGYLPKRASVSQIKDVDSITLEDALELLRYPITLGNHPKDGQPVIIKIAKAGFSVRHRRTIASVPKNLKPNDINLEKALELLSSK
        KSGPYGFYVQLGEDRKGY+PKR SVSQIKDV SITLEDALELLRYPITLGNHPKDG  V+IKI KAGF+VRHRRTIASVPKNLKPND++L KALELLSSK
Subjt:  KSGPYGFYVQLGEDRKGYLPKRASVSQIKDVDSITLEDALELLRYPITLGNHPKDGQPVIIKIAKAGFSVRHRRTIASVPKNLKPNDINLEKALELLSSK

Query:  DVRRCGRPKSKPKVEEAVEA
        DVRRCGRPKSKPKVEEAVEA
Subjt:  DVRRCGRPKSKPKVEEAVEA

TrEMBL top hits

e value

%identity

Alignment

A0A6J1CSY4 Omega-protein

1.2e-222

78.88

Show/hide

Query:  LAQKLYEGIQLADGKAAGLITYPRTDGLHISDEAVKDIRSLIIQRYGQNFVSESAPKYFKKVKNAQEAHEAIRPTDMLQLPSMLVGTLDEDSHKLYSLIW
        LAQKLYEGIQLADGKAAGLITYPRTDGLHISDEAVKDIRSLIIQRYGQNFVSESA KYFKKVKNAQEAHEAIRPTD+ QLPSMLVGTLDEDSHKLYSLIW
Subjt:  LAQKLYEGIQLADGKAAGLITYPRTDGLHISDEAVKDIRSLIIQRYGQNFVSESAPKYFKKVKNAQEAHEAIRPTDMLQLPSMLVGTLDEDSHKLYSLIW

Query:  LERWRAKWNPLSLNRGEWVDNASTNS-----QAKGLAKTRGIFSKFKMSGRDTEDKSHPYLKLRLLWLRVGSYIKTGDQLSLGGVELKQHFTQPPPRYSE
        L     +  P S+     +D+   N            + RG    F+    D   +       R    R+ + ++ GDQLSL  VELKQHFTQPPPRYSE
Subjt:  LERWRAKWNPLSLNRGEWVDNASTNS-----QAKGLAKTRGIFSKFKMSGRDTEDKSHPYLKLRLLWLRVGSYIKTGDQLSLGGVELKQHFTQPPPRYSE

Query:  GTLVKRMEELGIGRPSTYATTLKVLQDRNYVSVKSRVLHPEFRGRMVSAFLCHHFSEVTDYSFTADMETELDNVSAGLTEWKGLLRDYWTRFSSYCERAT
        GTLVKRMEELGIGRPSTYATTLKVLQDRNYVSVKSRVLHPEFRGRMVSAFLCHHFSEVTDYSFTADMETELDNVSAGLTEWKGLLRDYWTRFSSYCE A 
Subjt:  GTLVKRMEELGIGRPSTYATTLKVLQDRNYVSVKSRVLHPEFRGRMVSAFLCHHFSEVTDYSFTADMETELDNVSAGLTEWKGLLRDYWTRFSSYCERAT

Query:  NVHIHQVEKMLEKKFGDFLFSFLPDNCRTCP----------------------------RYIAKTLYGEDEEEVTPQNNNSVEEPKLLGLHPVSNEKILL
        +VHIHQVEKMLEKKFGDFLFSFLPDNCRTCP                            +YIAKTLYGED EEVTPQNNNSVEEPKLLGLHPVSNEKILL
Subjt:  NVHIHQVEKMLEKKFGDFLFSFLPDNCRTCP----------------------------RYIAKTLYGEDEEEVTPQNNNSVEEPKLLGLHPVSNEKILL

Query:  KSGPYGFYVQLGEDRKGYLPKRASVSQIKDVDSITLEDALELLRYPITLGNHPKDGQPVIIKIAKAGFSVRHRRTIASVPKNLKPNDINLEKALELLSSK
        KSGPYGFYVQLGEDRKGYLPKRASVSQIK VDSITLEDALELLRYPITLGNHPKDGQPVIIKIAKAGFSVRHRRTIA++PKNLKPN I LEKALELLSS 
Subjt:  KSGPYGFYVQLGEDRKGYLPKRASVSQIKDVDSITLEDALELLRYPITLGNHPKDGQPVIIKIAKAGFSVRHRRTIASVPKNLKPNDINLEKALELLSSK

Query:  DVRRCGRPKSKPKVEE
        DVRRCGRPKSKPKVEE
Subjt:  DVRRCGRPKSKPKVEE

A0A6J1F8P8 Omega-protein

2.2e-218

76.15

Show/hide

Query:  LAQKLYEGIQLADGKAAGLITYPRTDGLHISDEAVKDIRSLIIQRYGQNFVSESAPKYFKKVKNAQEAHEAIRPTDMLQLPSMLVGTLDEDSHKLYSLIW
        LAQKLYEGIQLADGKAAGLITYPRTDGLHISDEAVKDIRSLI QRYG+NFVSESA KYFKKVKNAQEAHEAIRPTD+ +LPSMLVGTLDEDSHKLYSLIW
Subjt:  LAQKLYEGIQLADGKAAGLITYPRTDGLHISDEAVKDIRSLIIQRYGQNFVSESAPKYFKKVKNAQEAHEAIRPTDMLQLPSMLVGTLDEDSHKLYSLIW

Query:  LERWRAKWNPLSLNRGEWVDNASTNSQAKGLAKTRGIFSKFKMSGRDTE-----DKSHPYLKLRLLWLRVGSYIKTGDQLSLGGVELKQHFTQPPPRYSE
        L     +  P    + +     +  S       +R  F  F+    D E      K H   +   L+ R+ + +K+GDQLSL  VELKQHFTQPPPRYSE
Subjt:  LERWRAKWNPLSLNRGEWVDNASTNSQAKGLAKTRGIFSKFKMSGRDTE-----DKSHPYLKLRLLWLRVGSYIKTGDQLSLGGVELKQHFTQPPPRYSE

Query:  GTLVKRMEELGIGRPSTYATTLKVLQDRNYVSVKSRVLHPEFRGRMVSAFLCHHFSEVTDYSFTADMETELDNVSAGLTEWKGLLRDYWTRFSSYCERAT
        GTLVK+MEELGIGRPSTYA+TLKVLQDRNY+SVKSRVLHPEFRGRMVSAFLCHHFSEVTDYSFTADME ELDNVSAGLTEWKGLL+DYWTRFS+YCERA 
Subjt:  GTLVKRMEELGIGRPSTYATTLKVLQDRNYVSVKSRVLHPEFRGRMVSAFLCHHFSEVTDYSFTADMETELDNVSAGLTEWKGLLRDYWTRFSSYCERAT

Query:  NVHIHQVEKMLEKKFGDFLFSFLPDNCRTCP----------------------------RYIAKTLYGEDEEEVTPQNNNSVEEPKLLGLHPVSNEKILL
        NVHIHQVEKMLEKK+ DFLFSFLPDNCR+CP                            +YIAKTLYGEDEEEVTPQNN SVEEPKLLGLHPVS+EKILL
Subjt:  NVHIHQVEKMLEKKFGDFLFSFLPDNCRTCP----------------------------RYIAKTLYGEDEEEVTPQNNNSVEEPKLLGLHPVSNEKILL

Query:  KSGPYGFYVQLGEDRKGYLPKRASVSQIKDVDSITLEDALELLRYPITLGNHPKDGQPVIIKIAKAGFSVRHRRTIASVPKNLKPNDINLEKALELLSSK
        KSGPYGFYVQLGEDRKGY+PKR SVSQIKDVDSITLEDALELLRYPITLGNHPKDGQ V+IKI KAGF+VRHRRTIASVPKNLKPND++L KALELLSS+
Subjt:  KSGPYGFYVQLGEDRKGYLPKRASVSQIKDVDSITLEDALELLRYPITLGNHPKDGQPVIIKIAKAGFSVRHRRTIASVPKNLKPNDINLEKALELLSSK

Query:  DVRRCGRPKSKPKVEEAVEA
        DVRRCGRPKSK K EEAVEA
Subjt:  DVRRCGRPKSKPKVEEAVEA

A0A6J1F9K7 Omega-protein

2.2e-218

76.15

Show/hide

Query:  LAQKLYEGIQLADGKAAGLITYPRTDGLHISDEAVKDIRSLIIQRYGQNFVSESAPKYFKKVKNAQEAHEAIRPTDMLQLPSMLVGTLDEDSHKLYSLIW
        LAQKLYEGIQLADGKAAGLITYPRTDGLHISDEAVKDIRSLI QRYG+NFVSESA KYFKKVKNAQEAHEAIRPTD+ +LPSMLVGTLDEDSHKLYSLIW
Subjt:  LAQKLYEGIQLADGKAAGLITYPRTDGLHISDEAVKDIRSLIIQRYGQNFVSESAPKYFKKVKNAQEAHEAIRPTDMLQLPSMLVGTLDEDSHKLYSLIW

Query:  LERWRAKWNPLSLNRGEWVDNASTNSQAKGLAKTRGIFSKFKMSGRDTE-----DKSHPYLKLRLLWLRVGSYIKTGDQLSLGGVELKQHFTQPPPRYSE
        L     +  P    + +     +  S       +R  F  F+    D E      K H   +   L+ R+ + +K+GDQLSL  VELKQHFTQPPPRYSE
Subjt:  LERWRAKWNPLSLNRGEWVDNASTNSQAKGLAKTRGIFSKFKMSGRDTE-----DKSHPYLKLRLLWLRVGSYIKTGDQLSLGGVELKQHFTQPPPRYSE

Query:  GTLVKRMEELGIGRPSTYATTLKVLQDRNYVSVKSRVLHPEFRGRMVSAFLCHHFSEVTDYSFTADMETELDNVSAGLTEWKGLLRDYWTRFSSYCERAT
        GTLVK+MEELGIGRPSTYA+TLKVLQDRNY+SVKSRVLHPEFRGRMVSAFLCHHFSEVTDYSFTADME ELDNVSAGLTEWKGLL+DYWTRFS+YCERA 
Subjt:  GTLVKRMEELGIGRPSTYATTLKVLQDRNYVSVKSRVLHPEFRGRMVSAFLCHHFSEVTDYSFTADMETELDNVSAGLTEWKGLLRDYWTRFSSYCERAT

Query:  NVHIHQVEKMLEKKFGDFLFSFLPDNCRTCP----------------------------RYIAKTLYGEDEEEVTPQNNNSVEEPKLLGLHPVSNEKILL
        NVHIHQVEKMLEKK+ DFLFSFLPDNCR+CP                            +YIAKTLYGEDEEEVTPQNN SVEEPKLLGLHPVS+EKILL
Subjt:  NVHIHQVEKMLEKKFGDFLFSFLPDNCRTCP----------------------------RYIAKTLYGEDEEEVTPQNNNSVEEPKLLGLHPVSNEKILL

Query:  KSGPYGFYVQLGEDRKGYLPKRASVSQIKDVDSITLEDALELLRYPITLGNHPKDGQPVIIKIAKAGFSVRHRRTIASVPKNLKPNDINLEKALELLSSK
        KSGPYGFYVQLGEDRKGY+PKR SVSQIKDVDSITLEDALELLRYPITLGNHPKDGQ V+IKI KAGF+VRHRRTIASVPKNLKPND++L KALELLSS+
Subjt:  KSGPYGFYVQLGEDRKGYLPKRASVSQIKDVDSITLEDALELLRYPITLGNHPKDGQPVIIKIAKAGFSVRHRRTIASVPKNLKPNDINLEKALELLSSK

Query:  DVRRCGRPKSKPKVEEAVEA
        DVRRCGRPKSK K EEAVEA
Subjt:  DVRRCGRPKSKPKVEEAVEA

A0A6J1IF86 Omega-protein

2.0e-219

76.73

Show/hide

Query:  LAQKLYEGIQLADGKAAGLITYPRTDGLHISDEAVKDIRSLIIQRYGQNFVSESAPKYFKKVKNAQEAHEAIRPTDMLQLPSMLVGTLDEDSHKLYSLIW
        LAQKLYEGIQLADGKAAGLITYPRTDGLHISDEAVKDIRSLI QRYG NFVSESA KYFKKVKNAQEAHEAIRPTD+ +LPSMLVGTLDEDSHKLYSLIW
Subjt:  LAQKLYEGIQLADGKAAGLITYPRTDGLHISDEAVKDIRSLIIQRYGQNFVSESAPKYFKKVKNAQEAHEAIRPTDMLQLPSMLVGTLDEDSHKLYSLIW

Query:  LERWRAKWNPLSLNRGEWVDNASTNSQAKGLAKTRGIFSKFKMSGRDTE-----DKSHPYLKLRLLWLRVGSYIKTGDQLSLGGVELKQHFTQPPPRYSE
        L     +  P    + +     +  S       +R  F  F+    D E      K H   +   L+ R+ + +K+GDQLSL  VELKQHFTQPPPRYSE
Subjt:  LERWRAKWNPLSLNRGEWVDNASTNSQAKGLAKTRGIFSKFKMSGRDTE-----DKSHPYLKLRLLWLRVGSYIKTGDQLSLGGVELKQHFTQPPPRYSE

Query:  GTLVKRMEELGIGRPSTYATTLKVLQDRNYVSVKSRVLHPEFRGRMVSAFLCHHFSEVTDYSFTADMETELDNVSAGLTEWKGLLRDYWTRFSSYCERAT
        GTLVK+MEELGIGRPSTYA+TLKVLQDRNY+SVKSRVLHPEFRGRMVSAFLCHHFSEVTDYSFTADME ELDNVSAGLTEWKGLLRDYWTRFS+YCERA 
Subjt:  GTLVKRMEELGIGRPSTYATTLKVLQDRNYVSVKSRVLHPEFRGRMVSAFLCHHFSEVTDYSFTADMETELDNVSAGLTEWKGLLRDYWTRFSSYCERAT

Query:  NVHIHQVEKMLEKKFGDFLFSFLPDNCRTCP----------------------------RYIAKTLYGEDEEEVTPQNNNSVEEPKLLGLHPVSNEKILL
        NVHIHQVEKMLEKK+ DFLFSFLPDNCRTCP                            +YIAKTLYGEDEEEVTPQNN SVEEPKLLGLHPVS+EKILL
Subjt:  NVHIHQVEKMLEKKFGDFLFSFLPDNCRTCP----------------------------RYIAKTLYGEDEEEVTPQNNNSVEEPKLLGLHPVSNEKILL

Query:  KSGPYGFYVQLGEDRKGYLPKRASVSQIKDVDSITLEDALELLRYPITLGNHPKDGQPVIIKIAKAGFSVRHRRTIASVPKNLKPNDINLEKALELLSSK
        KSGPYGFYVQLGEDRKGY+PKR SVSQIKDV SITLEDALELLRYPITLGNHPKDG  V+IKI KAGF+VRHRRTIASVPKNLKPND++L KALELLSSK
Subjt:  KSGPYGFYVQLGEDRKGYLPKRASVSQIKDVDSITLEDALELLRYPITLGNHPKDGQPVIIKIAKAGFSVRHRRTIASVPKNLKPNDINLEKALELLSSK

Query:  DVRRCGRPKSKPKVEEAVEA
        DVRRCGRPKSKPKVEEAVEA
Subjt:  DVRRCGRPKSKPKVEEAVEA

A0A6J1IMZ7 Omega-protein

2.0e-219

76.73

Show/hide

Query:  LAQKLYEGIQLADGKAAGLITYPRTDGLHISDEAVKDIRSLIIQRYGQNFVSESAPKYFKKVKNAQEAHEAIRPTDMLQLPSMLVGTLDEDSHKLYSLIW
        LAQKLYEGIQLADGKAAGLITYPRTDGLHISDEAVKDIRSLI QRYG NFVSESA KYFKKVKNAQEAHEAIRPTD+ +LPSMLVGTLDEDSHKLYSLIW
Subjt:  LAQKLYEGIQLADGKAAGLITYPRTDGLHISDEAVKDIRSLIIQRYGQNFVSESAPKYFKKVKNAQEAHEAIRPTDMLQLPSMLVGTLDEDSHKLYSLIW

Query:  LERWRAKWNPLSLNRGEWVDNASTNSQAKGLAKTRGIFSKFKMSGRDTE-----DKSHPYLKLRLLWLRVGSYIKTGDQLSLGGVELKQHFTQPPPRYSE
        L     +  P    + +     +  S       +R  F  F+    D E      K H   +   L+ R+ + +K+GDQLSL  VELKQHFTQPPPRYSE
Subjt:  LERWRAKWNPLSLNRGEWVDNASTNSQAKGLAKTRGIFSKFKMSGRDTE-----DKSHPYLKLRLLWLRVGSYIKTGDQLSLGGVELKQHFTQPPPRYSE

Query:  GTLVKRMEELGIGRPSTYATTLKVLQDRNYVSVKSRVLHPEFRGRMVSAFLCHHFSEVTDYSFTADMETELDNVSAGLTEWKGLLRDYWTRFSSYCERAT
        GTLVK+MEELGIGRPSTYA+TLKVLQDRNY+SVKSRVLHPEFRGRMVSAFLCHHFSEVTDYSFTADME ELDNVSAGLTEWKGLLRDYWTRFS+YCERA 
Subjt:  GTLVKRMEELGIGRPSTYATTLKVLQDRNYVSVKSRVLHPEFRGRMVSAFLCHHFSEVTDYSFTADMETELDNVSAGLTEWKGLLRDYWTRFSSYCERAT

Query:  NVHIHQVEKMLEKKFGDFLFSFLPDNCRTCP----------------------------RYIAKTLYGEDEEEVTPQNNNSVEEPKLLGLHPVSNEKILL
        NVHIHQVEKMLEKK+ DFLFSFLPDNCRTCP                            +YIAKTLYGEDEEEVTPQNN SVEEPKLLGLHPVS+EKILL
Subjt:  NVHIHQVEKMLEKKFGDFLFSFLPDNCRTCP----------------------------RYIAKTLYGEDEEEVTPQNNNSVEEPKLLGLHPVSNEKILL

Query:  KSGPYGFYVQLGEDRKGYLPKRASVSQIKDVDSITLEDALELLRYPITLGNHPKDGQPVIIKIAKAGFSVRHRRTIASVPKNLKPNDINLEKALELLSSK
        KSGPYGFYVQLGEDRKGY+PKR SVSQIKDV SITLEDALELLRYPITLGNHPKDG  V+IKI KAGF+VRHRRTIASVPKNLKPND++L KALELLSSK
Subjt:  KSGPYGFYVQLGEDRKGYLPKRASVSQIKDVDSITLEDALELLRYPITLGNHPKDGQPVIIKIAKAGFSVRHRRTIASVPKNLKPNDINLEKALELLSSK

Query:  DVRRCGRPKSKPKVEEAVEA
        DVRRCGRPKSKPKVEEAVEA
Subjt:  DVRRCGRPKSKPKVEEAVEA

SwissProt top hits

e value

%identity

Alignment

Q1RIM1 DNA topoisomerase 1

3.7e-77

36.75

Show/hide

Query:  LAQKLYEGIQLADGKAAGLITYPRTDGLHISDEAVKDIRSLIIQRYGQNFVSESAPKYFKKVKNAQEAHEAIRPTDMLQLPSMLVGTLDEDSHKLYSLIW
        +AQKLYEG+ +   +  GLITY RTDG+ +S++AV +IR LI + YG  ++  S   Y  KVKNAQEAHEAIRPT++  +P+ L   L++D +KLY LIW
Subjt:  LAQKLYEGIQLADGKAAGLITYPRTDGLHISDEAVKDIRSLIIQRYGQNFVSESAPKYFKKVKNAQEAHEAIRPTDMLQLPSMLVGTLDEDSHKLYSLIW

Query:  LERWRAKWNPLSLNRGEWVDNASTNSQAKG-LAKTRG---IFSKFKMSGRDTEDKSHPYLKLRLLWLRVGSYIKTGDQLSLGGVELKQHFTQPPPRYSEG
              +   + ++    + NA+  S+ K  LA+  G    F  F    R++ D         L  L+   ++KT + +        QHFT+PPPRYSE 
Subjt:  LERWRAKWNPLSLNRGEWVDNASTNSQAKG-LAKTRG---IFSKFKMSGRDTEDKSHPYLKLRLLWLRVGSYIKTGDQLSLGGVELKQHFTQPPPRYSEG

Query:  TLVKRMEELGIGRPSTYATTLKVLQDRNYVSVKSRVLHPEFRGRMVSAFLCHHFSEVTDYSFTADMETELDNVSAGLTEWKGLLRDYWTRFS--------
        +LVK++EELGIGRPSTYAT L VLQDR YV+++ +   PE  GR+V+ FL   F +  +Y FTA +E ELD ++AG  EWK  L ++W  F+        
Subjt:  TLVKRMEELGIGRPSTYATTLKVLQDRNYVSVKSRVLHPEFRGRMVSAFLCHHFSEVTDYSFTADMETELDNVSAGLTEWKGLLRDYWTRFS--------

Query:  -------SYCERATNVHIHQVEK-----------MLEKKFGDFLFSFLPDNCRTCPRYIAKTLYGEDEEEVTPQNNNSVEEPKLLGLHPVSNEKILLKSG
               SY ++A + HI    K            L  K G F       N   C  +    + G D  E   +  + V E K+LG      E I LK G
Subjt:  -------SYCERATNVHIHQVEK-----------MLEKKFGDFLFSFLPDNCRTCPRYIAKTLYGEDEEEVTPQNNNSVEEPKLLGLHPVSNEKILLKSG

Query:  PYGFYVQLGEDRKGYL-PKRASVSQIKDVDSITLEDALELLRYPITLGNHPKDGQPVIIKIAKAGFSVRHRRTIASVPKNLKPNDINLEKALELLSSK
        PYG Y+Q GE     + PKR+ +    + + ITL+ AL+LL  P+ +GNH + G+ V++   K G  +++     S+PK     +++L+ A++L+  K
Subjt:  PYGFYVQLGEDRKGYL-PKRASVSQIKDVDSITLEDALELLRYPITLGNHPKDGQPVIIKIAKAGFSVRHRRTIASVPKNLKPNDINLEKALELLSSK

Q4UM42 DNA topoisomerase 1

6.3e-77

36.35

Show/hide

Query:  LAQKLYEGIQLADGKAAGLITYPRTDGLHISDEAVKDIRSLIIQRYGQNFVSESAPKYFKKVKNAQEAHEAIRPTDMLQLPSMLVGTLDEDSHKLYSLIW
        +AQKLYEG+ +   +  GLITY RTDG+ +S++A+ DIR LI + YG  ++  S   Y  KVKNAQEAHEAIRPT++   P  L   L++D +KLY LIW
Subjt:  LAQKLYEGIQLADGKAAGLITYPRTDGLHISDEAVKDIRSLIIQRYGQNFVSESAPKYFKKVKNAQEAHEAIRPTDMLQLPSMLVGTLDEDSHKLYSLIW

Query:  LERWRAKWNPLSLNRGEWVDNASTNSQAKGLAKTRG---IFSKFKMSGRDTEDKSHPYLKLRLLWLRVGSYIKTGDQLSLGGVELKQHFTQPPPRYSEGT
              +   + +   + V  +  +   + LAK  G    F  F    R++ D         L  L+    +KT + +        QHFT+PPPRYSE +
Subjt:  LERWRAKWNPLSLNRGEWVDNASTNSQAKGLAKTRG---IFSKFKMSGRDTEDKSHPYLKLRLLWLRVGSYIKTGDQLSLGGVELKQHFTQPPPRYSEGT

Query:  LVKRMEELGIGRPSTYATTLKVLQDRNYVSVKSRVLHPEFRGRMVSAFLCHHFSEVTDYSFTADMETELDNVSAGLTEWKGLLRDYWTRFSSYCERATNV
        LVK++EELGIGRPSTYA+ L VLQDR YVS++ +   PE  GR+V+ FL   F +  +Y FTA +E ELD ++AG  EWK  L ++W+ F+   E     
Subjt:  LVKRMEELGIGRPSTYATTLKVLQDRNYVSVKSRVLHPEFRGRMVSAFLCHHFSEVTDYSFTADMETELDNVSAGLTEWKGLLRDYWTRFSSYCERATNV

Query:  HIHQVEKMLEKKFGDFLFSFLPD-----NCRT---------------CPRYIAKT-----LYGEDEEEVTPQNNNSVEEPKLLGLHPVSNEKILLKSGPY
         I ++   ++K     LFS   +     +C+T               C  Y   T     + G D  E       +  E K+LG      E I LK GPY
Subjt:  HIHQVEKMLEKKFGDFLFSFLPD-----NCRT---------------CPRYIAKT-----LYGEDEEEVTPQNNNSVEEPKLLGLHPVSNEKILLKSGPY

Query:  GFYVQLGEDRKGYLPKRASVSQIKDVDSITLEDALELLRYPITLGNHPKDGQPVIIKIAKAGFSVRHRRTIASVPKNLKPNDINLEKALELLSSKDVR
        G YVQLGE      PKR+ V    + + ITLE AL+LL  P+ +G H   G+ ++I   K G  +++     S+PK     +++L+ A++L+     +
Subjt:  GFYVQLGEDRKGYLPKRASVSQIKDVDSITLEDALELLRYPITLGNHPKDGQPVIIKIAKAGFSVRHRRTIASVPKNLKPNDINLEKALELLSSKDVR

Q68X45 DNA topoisomerase 1

8.3e-77

36.55

Show/hide

Query:  LAQKLYEGIQLADGKAAGLITYPRTDGLHISDEAVKDIRSLIIQRYGQNFVSESAPKYFKKVKNAQEAHEAIRPTDMLQLPSMLVGTLDEDSHKLYSLIW
        +AQKLYEG+ +   +  GLITY RTDG+ +S++A+ DIR LI + YG  ++  +   Y  KVKNAQEAHEAIRPT++   P  L   L++D +KLY LIW
Subjt:  LAQKLYEGIQLADGKAAGLITYPRTDGLHISDEAVKDIRSLIIQRYGQNFVSESAPKYFKKVKNAQEAHEAIRPTDMLQLPSMLVGTLDEDSHKLYSLIW

Query:  LERWRAKWNPLSLNRGEWVDNASTNSQAKGLAKTRG---IFSKFKMSGRDTEDKSHPYLKLRLLWLRVGSYIKTGDQLSLGGVELKQHFTQPPPRYSEGT
              +   + ++     + AS N +   LAK  G    F  F    R++ D         L  L+   +IKT + +        +HFT+PPPRYSE +
Subjt:  LERWRAKWNPLSLNRGEWVDNASTNSQAKGLAKTRG---IFSKFKMSGRDTEDKSHPYLKLRLLWLRVGSYIKTGDQLSLGGVELKQHFTQPPPRYSEGT

Query:  LVKRMEELGIGRPSTYATTLKVLQDRNYVSVKSRVLHPEFRGRMVSAFLCHHFSEVTDYSFTADMETELDNVSAGLTEWKGLLRDYWTRFSSYCERATNV
        LVK++EELGIGRPSTYA+ L VLQDR YV+++ +   PE  GR+V+ FL   F +  +Y FTA +E ELD ++AG  EWK  L ++W+ F++  E     
Subjt:  LVKRMEELGIGRPSTYATTLKVLQDRNYVSVKSRVLHPEFRGRMVSAFLCHHFSEVTDYSFTADMETELDNVSAGLTEWKGLLRDYWTRFSSYCERATNV

Query:  HIHQVEKMLEKK-----FGDFLFSFLPDNCRT---------------CPRYIAKT-----LYGEDEEEVTPQNNNSVEEPKLLGLHPVSNEKILLKSGPY
         I ++   L+K      FG+   S +  +C+T               C  Y   T     + G D  E     +  + + K+LG       +I LK+GPY
Subjt:  HIHQVEKMLEKK-----FGDFLFSFLPDNCRT---------------CPRYIAKT-----LYGEDEEEVTPQNNNSVEEPKLLGLHPVSNEKILLKSGPY

Query:  GFYVQLGEDRKGYLPKRASVSQIKDVDSITLEDALELLRYPITLGNHPKDGQPVIIKIAKAGFSVRHRRTIASVPKNLKPNDINLEKALELLSSKDVR
        G Y+QLGE      PKR  V        ITLE AL+LL  P+ +G H   G+ +II  +K G  +++     SVPK     ++NL+ A++L+ +   +
Subjt:  GFYVQLGEDRKGYLPKRASVSQIKDVDSITLEDALELLRYPITLGNHPKDGQPVIIKIAKAGFSVRHRRTIASVPKNLKPNDINLEKALELLSSKDVR

Q92IH1 DNA topoisomerase 1

5.0e-74

35.21

Show/hide

Query:  LAQKLYEGIQLADGKAAGLITYPRTDGLHISDEAVKDIRSLIIQRYGQNFVSESAPKYFKKVKNAQEAHEAIRPTDMLQLPSMLVGTLDEDSHKLYSLIW
        +AQKLYEG+ +   +  GLITY RTDG+ +S++A+ DIR LI + YG  ++  S   Y  KVKNAQEAHEAIRPT++   P  L   LD+D +KLY LIW
Subjt:  LAQKLYEGIQLADGKAAGLITYPRTDGLHISDEAVKDIRSLIIQRYGQNFVSESAPKYFKKVKNAQEAHEAIRPTDMLQLPSMLVGTLDEDSHKLYSLIW

Query:  LERWRAKWNPLSLNRGEWVDNASTNSQ--AKGLAKTRGIFSKFKMSGRDTEDKSHPYLKLRLLWLRVGSYIKTGDQLSLGGVELKQHFTQPPPRYSEGTL
              +   + ++     + AS N +  AK    T      +K+     +D++    K+          +K  + L    V   QHFT+PPPRYSE +L
Subjt:  LERWRAKWNPLSLNRGEWVDNASTNSQ--AKGLAKTRGIFSKFKMSGRDTEDKSHPYLKLRLLWLRVGSYIKTGDQLSLGGVELKQHFTQPPPRYSEGTL

Query:  VKRMEELGIGRPSTYATTLKVLQDRNYVSVKSRVLHPEFRGRMVSAFLCHHFSEVTDYSFTADMETELDNVSAGLTEWKGLLRDYWTRFSSYCERATNVH
        VK++EELGIGRPSTYA+ L VLQDR YV+++ +   PE  GR+V+ FL   F +  +Y FTA +E ELD ++AG  EWK  L ++W+ F+   E      
Subjt:  VKRMEELGIGRPSTYATTLKVLQDRNYVSVKSRVLHPEFRGRMVSAFLCHHFSEVTDYSFTADMETELDNVSAGLTEWKGLLRDYWTRFSSYCERATNVH

Query:  IHQVEKMLEKK-----FGDFLFSFLPDNCRT---------------CPRYIAKT-----LYGEDEEEVTPQNNNSVEEPKLLGLHPVSNEKILLKSGPYG
        I ++   ++K      FG+   S +  +C T               C  Y   T     + G D  E   +      E K+LG       +I LK GPYG
Subjt:  IHQVEKMLEKK-----FGDFLFSFLPDNCRT---------------CPRYIAKT-----LYGEDEEEVTPQNNNSVEEPKLLGLHPVSNEKILLKSGPYG

Query:  FYVQLGEDRKGYLPKRASVSQIKDVDSITLEDALELLRYPITLGNHPKDGQPVIIKIAKAGFSVRHRRTIASVPKNLKPNDINLEKALELLSSKDVR
         Y+QLG+      PKR+ V    + + ITL+ AL+LL  P+ +G H    + ++I   K G  +++     SV K     +++L+ A++L+     +
Subjt:  FYVQLGEDRKGYLPKRASVSQIKDVDSITLEDALELLRYPITLGNHPKDGQPVIIKIAKAGFSVRHRRTIASVPKNLKPNDINLEKALELLSSKDVR

Q9ZDK2 DNA topoisomerase 1

2.0e-75

36.35

Show/hide

Query:  LAQKLYEGIQLADGKAAGLITYPRTDGLHISDEAVKDIRSLIIQRYGQNFVSESAPKYFKKVKNAQEAHEAIRPTDMLQLPSMLVGTLDEDSHKLYSLIW
        +AQKLYEG+ +   +  GLITY RTDG+ +S++A+ DIR LI + YG  ++      Y  KVKNAQEAHEAIRPT++   P  L   L++D +KLY LIW
Subjt:  LAQKLYEGIQLADGKAAGLITYPRTDGLHISDEAVKDIRSLIIQRYGQNFVSESAPKYFKKVKNAQEAHEAIRPTDMLQLPSMLVGTLDEDSHKLYSLIW

Query:  LERWRAKWNPLSLNRGEWVDNASTNSQAKGLAKTRG---IFSKFKMSGRDTEDKSHPYLKLRLLWLRVGSYIKTGDQLSLGGVELKQHFTQPPPRYSEGT
              +   + ++     + AS N +   LAK  G    F  F    R++ D         L  L+   +IKT + +        +HFT+PPPRYSE +
Subjt:  LERWRAKWNPLSLNRGEWVDNASTNSQAKGLAKTRG---IFSKFKMSGRDTEDKSHPYLKLRLLWLRVGSYIKTGDQLSLGGVELKQHFTQPPPRYSEGT

Query:  LVKRMEELGIGRPSTYATTLKVLQDRNYVSVKSRVLHPEFRGRMVSAFLCHHFSEVTDYSFTADMETELDNVSAGLTEWKGLLRDYWTRFSSYCERATNV
        LVK++EELGIGRPSTYA+ L VLQDR YV+++ +   PE  GR+V+ FL   F +  +Y FTA +E ELD ++AG  EWK  L ++W  F+   E     
Subjt:  LVKRMEELGIGRPSTYATTLKVLQDRNYVSVKSRVLHPEFRGRMVSAFLCHHFSEVTDYSFTADMETELDNVSAGLTEWKGLLRDYWTRFSSYCERATNV

Query:  HIHQVEKMLEKK-----FGDFLFSFLPDNCRT---------------CPRYIAKT-----LYGEDEEEVTPQNNNSVEEPKLLGLHPVSNEKILLKSGPY
         I ++   L+K      FG+   S +  +C+T               C  Y   T     + G D  E     +  + + K+LG       +I LK GPY
Subjt:  HIHQVEKMLEKK-----FGDFLFSFLPDNCRT---------------CPRYIAKT-----LYGEDEEEVTPQNNNSVEEPKLLGLHPVSNEKILLKSGPY

Query:  GFYVQLGEDRKGYLPKRASVSQIKDVDSITLEDALELLRYPITLGNHPKDGQPVIIKIAKAGFSVRHRRTIASVPKNLKPNDINLEKALELLSSKDVR
        G Y+QLGE      PKR  V        ITLE AL+LL  P+ +G H   G+ +II  +K G  +++     SVPK     +++L  A++L+ +   +
Subjt:  GFYVQLGEDRKGYLPKRASVSQIKDVDSITLEDALELLRYPITLGNHPKDGQPVIIKIAKAGFSVRHRRTIASVPKNLKPNDINLEKALELLSSKDVR

Arabidopsis top hits

e value

%identity

Alignment

AT4G31210.1 DNA topoisomerase, type IA, core

6.6e-170

57.95

Show/hide

Query:  LAQKLYEGIQLADGKAAGLITYPRTDGLHISDEAVKDIRSLIIQRYGQNFVSESAPKYFKKVKNAQEAHEAIRPTDMLQLPSMLVGTLDEDSHKLYSLIW
        LAQKLYEG+QL+DGK+AGLITY RTDGLHI+DEA+KDI+SL+ +RYG+NF S+S  KYFKKVKNAQEAHEAIRPTD+ +LPS +   LD DS KLY+LIW
Subjt:  LAQKLYEGIQLADGKAAGLITYPRTDGLHISDEAVKDIRSLIIQRYGQNFVSESAPKYFKKVKNAQEAHEAIRPTDMLQLPSMLVGTLDEDSHKLYSLIW

Query:  LERWRAKWNPLSLNRGEWVDNASTNSQAKGLAKTRGIFSKFKMSGRDTEDKS-----HPYLKLRLLWLRVGSYIKTGDQLSLGGVELKQHFTQPPPRYSE
              +  P S+ + +     ++ S     + ++  F  ++    D E K+     +     R    +  S +K GD L +G VELKQH TQ PPRYSE
Subjt:  LERWRAKWNPLSLNRGEWVDNASTNSQAKGLAKTRGIFSKFKMSGRDTEDKS-----HPYLKLRLLWLRVGSYIKTGDQLSLGGVELKQHFTQPPPRYSE

Query:  GTLVKRMEELGIGRPSTYATTLKVLQDRNYVSVKSRVLHPEFRGRMVSAFLCHHFSEVTDYSFTADMETELDNVSAGLTEWKGLLRDYWTRFSSYCERAT
        G+LVK++EELGIGRPSTYA+  +VLQ R YV++K+RVL+PEFR RMVSAFL H+F+E+TDYSFTADMETELDNVS G+TEWKGLLRDYWTRFS+YC+R  
Subjt:  GTLVKRMEELGIGRPSTYATTLKVLQDRNYVSVKSRVLHPEFRGRMVSAFLCHHFSEVTDYSFTADMETELDNVSAGLTEWKGLLRDYWTRFSSYCERAT

Query:  NVHIHQVEKMLEKKFGDFLFSFLPDNCRTCP----------------------------RYIAKTLYGEDEEEVTPQNNNSVEEPKLLGLHPVSNEKILL
        NV   QVEKMLEKK+ D LFS LP   RTCP                            ++IAKTLYGEDE+E  P  NN VEEPKLLGLHP ++EK++L
Subjt:  NVHIHQVEKMLEKKFGDFLFSFLPDNCRTCP----------------------------RYIAKTLYGEDEEEVTPQNNNSVEEPKLLGLHPVSNEKILL

Query:  KSGPYGFYVQLGEDRKGYLPKRASVSQIKDVDSITLEDALELLRYPITLGNHPKDGQPVIIKIAKAGFSVRHRRTIASVPKNLKPNDINLEKALELLSSK
        K GPYG YVQLGED+KG+ PKRA+ + IKDV+SITLE ALELLRYP+TLG HP+DGQPV++K++K+GF+++HRR +A+VPKN +P ++ LE+A++LLS K
Subjt:  KSGPYGFYVQLGEDRKGYLPKRASVSQIKDVDSITLEDALELLRYPITLGNHPKDGQPVIIKIAKAGFSVRHRRTIASVPKNLKPNDINLEKALELLSSK

Query:  DVRRCGRPKSKPKVEE
        +VR+ GRP      EE
Subjt:  DVRRCGRPKSKPKVEE

Sequences

Show/hide sequences

CDS sequence

Show/hide CDS sequence

CTTGCCCAGAAACTTTACGAGGGAATTCAATTGGCTGATGGCAAGGCAGCTGGCTTAATAACTTATCCAAGAACAGATGGGCTACATATTTCTGATGAAGCTGTTAAGGA
CATTCGCTCCTTGATTATACAGAGATATGGGCAGAATTTTGTATCAGAAAGTGCACCCAAATATTTTAAGAAGGTCAAGAATGCTCAAGAGGCTCATGAAGCAATCAGAC
CCACTGATATGCTACAATTACCATCAATGCTAGTAGGAACACTTGATGAAGATTCACACAAACTATACTCTCTTATTTGGCTCGAACGATGGCGTGCCAAATGGAACCCT
CTATCACTGAACAGAGGCGAATGGGTTGATAACGCTTCAACCAATTCCCAAGCGAAAGGGTTAGCAAAAACACGAGGCATTTTTAGCAAGTTTAAAATGTCTGGTAGAGA
TACTGAGGACAAGAGTCACCCTTACCTAAAACTGAGGTTATTGTGGCTTAGAGTGGGATCATATATCAAGACAGGGGATCAATTGTCTCTAGGTGGAGTTGAACTCAAGC
AACATTTTACCCAGCCCCCACCTCGCTATTCTGAGGGAACATTGGTTAAGAGGATGGAGGAGCTAGGGATTGGGAGACCTTCCACATATGCAACCACATTAAAAGTTTTA
CAGGACAGAAACTACGTGTCAGTGAAAAGTCGTGTTCTACATCCAGAATTTCGTGGGCGTATGGTGTCGGCATTTCTTTGTCACCATTTTTCTGAGGTCACTGATTATAG
TTTTACTGCTGACATGGAAACTGAGCTTGATAACGTCTCTGCCGGTTTAACTGAATGGAAAGGCCTCCTAAGAGATTATTGGACTCGATTCAGCTCATACTGTGAACGTG
CTACCAATGTTCATATTCACCAGGTGGAAAAGATGTTGGAGAAGAAATTTGGGGATTTCTTATTTTCTTTTCTTCCTGATAATTGCAGAACATGTCCAAGGTATATTGCA
AAAACATTATATGGTGAGGATGAAGAAGAAGTCACTCCTCAAAATAACAACAGTGTGGAGGAGCCAAAATTGCTTGGTCTTCATCCAGTTTCTAATGAAAAGATTCTTTT
GAAGAGTGGTCCATATGGGTTTTATGTGCAGCTTGGTGAGGACAGGAAAGGGTACTTGCCAAAAAGAGCCTCTGTTTCCCAGATAAAGGACGTGGACTCTATTACTCTTG
AGGATGCCCTTGAACTATTGCGCTACCCGATTACTTTGGGAAACCATCCAAAGGATGGTCAACCAGTGATAATAAAGATCGCAAAAGCTGGATTCTCAGTTAGACATCGG
CGCACGATAGCTTCTGTTCCCAAGAATTTGAAGCCGAATGATATCAACCTAGAGAAAGCGTTAGAGCTTCTGTCAAGTAAAGATGTTAGAAGATGTGGGCGGCCTAAAAG
CAAGCCCAAGGTTGAGGAAGCTGTTGAAGCCACGTAG

mRNA sequence

Show/hide mRNA sequence

Protein sequence

Show/hide protein sequence

LAQKLYEGIQLADGKAAGLITYPRTDGLHISDEAVKDIRSLIIQRYGQNFVSESAPKYFKKVKNAQEAHEAIRPTDMLQLPSMLVGTLDEDSHKLYSLIWLERWRAKWNP
LSLNRGEWVDNASTNSQAKGLAKTRGIFSKFKMSGRDTEDKSHPYLKLRLLWLRVGSYIKTGDQLSLGGVELKQHFTQPPPRYSEGTLVKRMEELGIGRPSTYATTLKVL
QDRNYVSVKSRVLHPEFRGRMVSAFLCHHFSEVTDYSFTADMETELDNVSAGLTEWKGLLRDYWTRFSSYCERATNVHIHQVEKMLEKKFGDFLFSFLPDNCRTCPRYIA
KTLYGEDEEEVTPQNNNSVEEPKLLGLHPVSNEKILLKSGPYGFYVQLGEDRKGYLPKRASVSQIKDVDSITLEDALELLRYPITLGNHPKDGQPVIIKIAKAGFSVRHR
RTIASVPKNLKPNDINLEKALELLSSKDVRRCGRPKSKPKVEEAVEAT

Sgr017868 (gene) of Monk fruit (Qingpiguo) v1 genome