CuGenDBv2

Gene ID	Sgr022035
Organism	Siraitia grosvenorii cv. Qingpiguo (Monk fruit (Qingpiguo) v1)
Description	3-hydroxy-3-methylglutaryl coenzyme A synthase
Genome location	tig00153874:132471..137240
RNA-Seq Expression	Sgr022035
Synteny	Sgr022035
Gene Ontology terms	GO:0006084 - acetyl-CoA metabolic process (biological process) GO:0010142 - farnesyl diphosphate biosynthetic process, mevalonate pathway (biological process) GO:0016126 - sterol biosynthetic process (biological process) GO:0004421 - hydroxymethylglutaryl-CoA synthase activity (molecular function)
InterPro domains	IPR000590 - Hydroxymethylglutaryl-coenzyme A synthase, active site IPR010122 - Hydroxymethylglutaryl-CoA synthase, eukaryotic IPR013528 - Hydroxymethylglutaryl-coenzyme A synthase, N-terminal IPR013746 - Hydroxymethylglutaryl-coenzyme A synthase, C-terminal domain IPR016039 - Thiolase-like

Homology

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GenBank top hits

e value

%identity

Alignment

AEM42970.1 hydroxymethylglutaryl-CoA synthase [Siraitia grosvenorii]

2.8e-254

95.91

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Query:  MAKNVGILAVDIYFPPTYVQQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIF
        MAKNVGILAVDIYFPPTYVQQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIF
Subjt:  MAKNVGILAVDIYFPPTYVQQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIF

Query:  EKHGNTDIEGVDSTNACYGGTAALLNCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFESRVRGSHMSHVYDFYKPNLASE
        EKHGNTDIEGVDSTNACYGGTAALLNCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFESRVRGSHMSHVYDFYKPNLASE
Subjt:  EKHGNTDIEGVDSTNACYGGTAALLNCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFESRVRGSHMSHVYDFYKPNLASE

Query:  YPVVDGKLSQTCYLMALDSCYKQLCHKYEKLEGKQFSISDADYFVFHSPYNKL-------------------IDEVAKEKLAPFSTLSGDESYQSRDLEK
        YPVVDGKLSQTCYLMALDSCYKQLCHKYEKLEGKQFSISDADYFVFHSPYNKL                   IDEVAKEKLAPFSTLSGDESYQSRDLEK
Subjt:  YPVVDGKLSQTCYLMALDSCYKQLCHKYEKLEGKQFSISDADYFVFHSPYNKL-------------------IDEVAKEKLAPFSTLSGDESYQSRDLEK

Query:  ISQQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLLHNKHNTLSGNRVILFSYGSGSTATMFSLKLNEGQHPFSLSNIAAILNVDKKLKSRHELVP
        ISQQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLLHNKHNTLSGNRVILFSYGSGSTATMFSLKLNEGQHPFSLSNIAAILNVDKKLKSRHELVP
Subjt:  ISQQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLLHNKHNTLSGNRVILFSYGSGSTATMFSLKLNEGQHPFSLSNIAAILNVDKKLKSRHELVP

Query:  EKFIEIMKLMEHRYGAKDFVTSKDCSLLSPGTYYLTEVDSLYRRFYAKNDGKSARFENGVVANGH
        EKFIEIMKLMEHRYGAKDFVTSKDCSLLSPGTYYLTEVDSLYRRFYAKNDGKSARFENGVVANGH
Subjt:  EKFIEIMKLMEHRYGAKDFVTSKDCSLLSPGTYYLTEVDSLYRRFYAKNDGKSARFENGVVANGH

KAG6577575.1 Hydroxymethylglutaryl-CoA synthase, partial [Cucurbita argyrosperma subsp. sororia]

7.2e-242

90.11

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Query:  MAKNVGILAVDIYFPPTYVQQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIF
        MAKNVGILA+DIYFPPTY++QEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIF
Subjt:  MAKNVGILAVDIYFPPTYVQQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIF

Query:  EKHGNTDIEGVDSTNACYGGTAALLNCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFESRVRGSHMSHVYDFYKPNLASE
        EKHGNTDIEGVDSTNACYGGTAAL NCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAML+GPDAPI FES++RGSHMSHVYDFYKPNLASE
Subjt:  EKHGNTDIEGVDSTNACYGGTAALLNCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFESRVRGSHMSHVYDFYKPNLASE

Query:  YPVVDGKLSQTCYLMALDSCYKQLCHKYEKLEGKQFSISDADYFVFHSPYNKL-------------------IDEVAKEKLAPFSTLSGDESYQSRDLEK
        YPVVDGKLSQTCYLMALDSCYKQLCHKYEKLEGKQFSISDADYFVFHSPYNKL                   IDEVAKEKLAPFSTLS DE+YQSRDLEK
Subjt:  YPVVDGKLSQTCYLMALDSCYKQLCHKYEKLEGKQFSISDADYFVFHSPYNKL-------------------IDEVAKEKLAPFSTLSGDESYQSRDLEK

Query:  ISQQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLLHNKHNTLSGNRVILFSYGSGSTATMFSLKLNEGQHPFSLSNIAAILNVDKKLKSRHELVP
        I+QQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLLHNK+N+L+GNRV+LFSYGSGSTATMFSLKLNEGQ PFSLSNI+AILNVDKKLKSRHELVP
Subjt:  ISQQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLLHNKHNTLSGNRVILFSYGSGSTATMFSLKLNEGQHPFSLSNIAAILNVDKKLKSRHELVP

Query:  EKFIEIMKLMEHRYGAKDFVTSKDCSLLSPGTYYLTEVDSLYRRFYAKNDGKSARFENGVVANGH
        EKF+EIM+LMEHRYGAKDFVTSKDCSLL  G+YYLTEVDSLYRRFYAK DG+S + ENGVVANGH
Subjt:  EKFIEIMKLMEHRYGAKDFVTSKDCSLLSPGTYYLTEVDSLYRRFYAKNDGKSARFENGVVANGH

XP_022152764.1 hydroxymethylglutaryl-CoA synthase [Momordica charantia]

4.8e-246

91.61

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Query:  MAKNVGILAVDIYFPPTYVQQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIF
        MAKN GIL VDIYFPPTYVQQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIF
Subjt:  MAKNVGILAVDIYFPPTYVQQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIF

Query:  EKHGNTDIEGVDSTNACYGGTAALLNCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFESRVRGSHMSHVYDFYKPNLASE
        EKHGNTDIEGVDSTNACYGGTAALLNCVNWVES+SWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFES++RGSHMSHVYDFYKPNLASE
Subjt:  EKHGNTDIEGVDSTNACYGGTAALLNCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFESRVRGSHMSHVYDFYKPNLASE

Query:  YPVVDGKLSQTCYLMALDSCYKQLCHKYEKLEGKQFSISDADYFVFHSPYNKL-------------------IDEVAKEKLAPFSTLSGDESYQSRDLEK
        YPVVDGKLSQTCYLMALDSCYKQLCHKYEKLEGKQFS+SDADYFVFHSPYNKL                   IDEVAKEKLAPFSTLS DESYQSRDLEK
Subjt:  YPVVDGKLSQTCYLMALDSCYKQLCHKYEKLEGKQFSISDADYFVFHSPYNKL-------------------IDEVAKEKLAPFSTLSGDESYQSRDLEK

Query:  ISQQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLLHNKHNTLSGNRVILFSYGSGSTATMFSLKLNEGQHPFSLSNIAAILNVDKKLKSRHELVP
        ISQQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISL+HNKH++LSGNRVILFSYGSGSTATMFSLK+NEGQHPFSLSNI+A+LNVDKKLKSRHEL+P
Subjt:  ISQQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLLHNKHNTLSGNRVILFSYGSGSTATMFSLKLNEGQHPFSLSNIAAILNVDKKLKSRHELVP

Query:  EKFIEIMKLMEHRYGAKDFVTSKDCSLLSPGTYYLTEVDSLYRRFYAKNDGKSARFENGVVANGH
        EKF+EIMKLMEHRYGAKDFVTSKDCSLL PGTYYLTEVDSLYRRFYAK D +SAR ENGVVANGH
Subjt:  EKFIEIMKLMEHRYGAKDFVTSKDCSLLSPGTYYLTEVDSLYRRFYAKNDGKSARFENGVVANGH

XP_023553213.1 hydroxymethylglutaryl-CoA synthase-like [Cucurbita pepo subsp. pepo]

2.5e-242

90.32

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Query:  MAKNVGILAVDIYFPPTYVQQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIF
        MAKNVGILA+DIYFPPTY+QQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIF
Subjt:  MAKNVGILAVDIYFPPTYVQQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIF

Query:  EKHGNTDIEGVDSTNACYGGTAALLNCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFESRVRGSHMSHVYDFYKPNLASE
        EKHGNTDIEGVDSTNACYGGTAAL NCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAML+GPDAPI FES++RGSHMSHVYDFYKPNLASE
Subjt:  EKHGNTDIEGVDSTNACYGGTAALLNCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFESRVRGSHMSHVYDFYKPNLASE

Query:  YPVVDGKLSQTCYLMALDSCYKQLCHKYEKLEGKQFSISDADYFVFHSPYNKL-------------------IDEVAKEKLAPFSTLSGDESYQSRDLEK
        YPVVDGKLSQTCYLMALDSCYKQLCHKYEKLEGKQFSISDADYFVFHSPYNKL                   IDEVAKEKLAPFSTLS DE+YQSRDLEK
Subjt:  YPVVDGKLSQTCYLMALDSCYKQLCHKYEKLEGKQFSISDADYFVFHSPYNKL-------------------IDEVAKEKLAPFSTLSGDESYQSRDLEK

Query:  ISQQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLLHNKHNTLSGNRVILFSYGSGSTATMFSLKLNEGQHPFSLSNIAAILNVDKKLKSRHELVP
        I+QQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLLHNK+N+L+GNRV+LFSYGSGSTATMFSLKLNEGQ PFSLSNI+AILNVDKKLKSRHELVP
Subjt:  ISQQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLLHNKHNTLSGNRVILFSYGSGSTATMFSLKLNEGQHPFSLSNIAAILNVDKKLKSRHELVP

Query:  EKFIEIMKLMEHRYGAKDFVTSKDCSLLSPGTYYLTEVDSLYRRFYAKNDGKSARFENGVVANGH
        EKF+EIM+LMEHRYGAKDFVTSKDCSLL  G+YYLTEVDSLYRRFYAK DG+S + ENGVVANGH
Subjt:  EKFIEIMKLMEHRYGAKDFVTSKDCSLLSPGTYYLTEVDSLYRRFYAKNDGKSARFENGVVANGH

XP_038903028.1 hydroxymethylglutaryl-CoA synthase [Benincasa hispida]

2.5e-242

90.97

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Query:  MAKNVGILAVDIYFPPTYVQQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIF
        MA NVGILA+DIYFPPTYVQQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLT VTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIF
Subjt:  MAKNVGILAVDIYFPPTYVQQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIF

Query:  EKHGNTDIEGVDSTNACYGGTAALLNCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFESRVRGSHMSHVYDFYKPNLASE
        EKHGNTDIEGVDSTNACYGGTAAL NCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFES++RGSHMSHVYDFYKPNLASE
Subjt:  EKHGNTDIEGVDSTNACYGGTAALLNCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFESRVRGSHMSHVYDFYKPNLASE

Query:  YPVVDGKLSQTCYLMALDSCYKQLCHKYEKLEGKQFSISDADYFVFHSPYNKL-------------------IDEVAKEKLAPFSTLSGDESYQSRDLEK
        YPVVDGKLSQTCYLMALDSCYKQLCHKYEKLEGKQFSIS+ADYFVFHSPYNKL                   IDE AKEKLAPFS LS DESYQSRDLEK
Subjt:  YPVVDGKLSQTCYLMALDSCYKQLCHKYEKLEGKQFSISDADYFVFHSPYNKL-------------------IDEVAKEKLAPFSTLSGDESYQSRDLEK

Query:  ISQQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLLHNKHNTLSGNRVILFSYGSGSTATMFSLKLNEGQHPFSLSNIAAILNVDKKLKSRHELVP
        I+QQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLLHNK+N+L GNRVILFSYGSGSTATMFSLKLNEGQ+PFSLSNI+AILNVDKKLKSRHELVP
Subjt:  ISQQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLLHNKHNTLSGNRVILFSYGSGSTATMFSLKLNEGQHPFSLSNIAAILNVDKKLKSRHELVP

Query:  EKFIEIMKLMEHRYGAKDFVTSKDCSLLSPGTYYLTEVDSLYRRFYAKNDGKSARFENGVVANGH
        EKF+EIM+LMEHRYGAKDFVTSKDCSLLSPGTYYLTEVDSLYRRFYAK DG+S + ENGVVANGH
Subjt:  EKFIEIMKLMEHRYGAKDFVTSKDCSLLSPGTYYLTEVDSLYRRFYAKNDGKSARFENGVVANGH

TrEMBL top hits

e value

%identity

Alignment

A0A6J1DH00 3-hydroxy-3-methylglutaryl coenzyme A synthase

2.3e-246

91.61

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Query:  MAKNVGILAVDIYFPPTYVQQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIF
        MAKN GIL VDIYFPPTYVQQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIF
Subjt:  MAKNVGILAVDIYFPPTYVQQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIF

Query:  EKHGNTDIEGVDSTNACYGGTAALLNCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFESRVRGSHMSHVYDFYKPNLASE
        EKHGNTDIEGVDSTNACYGGTAALLNCVNWVES+SWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFES++RGSHMSHVYDFYKPNLASE
Subjt:  EKHGNTDIEGVDSTNACYGGTAALLNCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFESRVRGSHMSHVYDFYKPNLASE

Query:  YPVVDGKLSQTCYLMALDSCYKQLCHKYEKLEGKQFSISDADYFVFHSPYNKL-------------------IDEVAKEKLAPFSTLSGDESYQSRDLEK
        YPVVDGKLSQTCYLMALDSCYKQLCHKYEKLEGKQFS+SDADYFVFHSPYNKL                   IDEVAKEKLAPFSTLS DESYQSRDLEK
Subjt:  YPVVDGKLSQTCYLMALDSCYKQLCHKYEKLEGKQFSISDADYFVFHSPYNKL-------------------IDEVAKEKLAPFSTLSGDESYQSRDLEK

Query:  ISQQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLLHNKHNTLSGNRVILFSYGSGSTATMFSLKLNEGQHPFSLSNIAAILNVDKKLKSRHELVP
        ISQQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISL+HNKH++LSGNRVILFSYGSGSTATMFSLK+NEGQHPFSLSNI+A+LNVDKKLKSRHEL+P
Subjt:  ISQQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLLHNKHNTLSGNRVILFSYGSGSTATMFSLKLNEGQHPFSLSNIAAILNVDKKLKSRHELVP

Query:  EKFIEIMKLMEHRYGAKDFVTSKDCSLLSPGTYYLTEVDSLYRRFYAKNDGKSARFENGVVANGH
        EKF+EIMKLMEHRYGAKDFVTSKDCSLL PGTYYLTEVDSLYRRFYAK D +SAR ENGVVANGH
Subjt:  EKFIEIMKLMEHRYGAKDFVTSKDCSLLSPGTYYLTEVDSLYRRFYAKNDGKSARFENGVVANGH

A0A6J1E6B9 3-hydroxy-3-methylglutaryl coenzyme A synthase

1.3e-241

89.89

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Query:  MAKNVGILAVDIYFPPTYVQQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIF
        MAKNVGILA+DI+FPPTY++QEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIF
Subjt:  MAKNVGILAVDIYFPPTYVQQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIF

Query:  EKHGNTDIEGVDSTNACYGGTAALLNCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFESRVRGSHMSHVYDFYKPNLASE
        EKHGNTDIEGVDSTNACYGGTAAL NCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAML+GPDAPI FES++RGSHMSHVYDFYKPNLASE
Subjt:  EKHGNTDIEGVDSTNACYGGTAALLNCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFESRVRGSHMSHVYDFYKPNLASE

Query:  YPVVDGKLSQTCYLMALDSCYKQLCHKYEKLEGKQFSISDADYFVFHSPYNKL-------------------IDEVAKEKLAPFSTLSGDESYQSRDLEK
        YPVVDGKLSQTCYLMALDSCYKQLCHKYEKLEGKQFSISDADYFVFHSPYNKL                   IDEVAKEKLAPFSTLS DE+YQSRDLEK
Subjt:  YPVVDGKLSQTCYLMALDSCYKQLCHKYEKLEGKQFSISDADYFVFHSPYNKL-------------------IDEVAKEKLAPFSTLSGDESYQSRDLEK

Query:  ISQQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLLHNKHNTLSGNRVILFSYGSGSTATMFSLKLNEGQHPFSLSNIAAILNVDKKLKSRHELVP
        I+QQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLLHNK+N+L+GNRV+LFSYGSGSTATMFSLKLNEGQ PFSLSNI+AILNVDKKLKSRHELVP
Subjt:  ISQQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLLHNKHNTLSGNRVILFSYGSGSTATMFSLKLNEGQHPFSLSNIAAILNVDKKLKSRHELVP

Query:  EKFIEIMKLMEHRYGAKDFVTSKDCSLLSPGTYYLTEVDSLYRRFYAKNDGKSARFENGVVANGH
        EKF+EIM+LMEHRYGAKDFVTSKDCSLL  G+YYLTEVDSLYRRFYAK DG+S + ENGVVANGH
Subjt:  EKFIEIMKLMEHRYGAKDFVTSKDCSLLSPGTYYLTEVDSLYRRFYAKNDGKSARFENGVVANGH

A0A6J1FE30 3-hydroxy-3-methylglutaryl coenzyme A synthase

1.1e-240

89.68

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Query:  MAKNVGILAVDIYFPPTYVQQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIF
        MAKNVGILAVDIYFPPT VQQEALEAHDGASKGKYTIGLGQDCMAFC+EVEDVISMSLTVVTSLLEKY IDPKQ+GRLEVGSETVIDKSKSIKTFLMQIF
Subjt:  MAKNVGILAVDIYFPPTYVQQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIF

Query:  EKHGNTDIEGVDSTNACYGGTAALLNCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFESRVRGSHMSHVYDFYKPNLASE
        EKHGNTDIEGVDSTNACYGGTAAL NCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFES++RGSHMSHVYDFYKPNLASE
Subjt:  EKHGNTDIEGVDSTNACYGGTAALLNCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFESRVRGSHMSHVYDFYKPNLASE

Query:  YPVVDGKLSQTCYLMALDSCYKQLCHKYEKLEGKQFSISDADYFVFHSPYNKL-------------------IDEVAKEKLAPFSTLSGDESYQSRDLEK
        YPVVDGKLSQTCYLMALDSCYKQLCHKYEKLEGK+F+ISDADYFVFHSPYNKL                   IDEV KEKLAPFSTLS DESYQSRDLEK
Subjt:  YPVVDGKLSQTCYLMALDSCYKQLCHKYEKLEGKQFSISDADYFVFHSPYNKL-------------------IDEVAKEKLAPFSTLSGDESYQSRDLEK

Query:  ISQQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLLHNKHNTLSGNRVILFSYGSGSTATMFSLKLNEGQHPFSLSNIAAILNVDKKLKSRHELVP
        I+QQLAKPLYD+KVQPSTLIPKQVGNMYTASLYAAFISLLHNKH++LSGNRVILFSYGSGSTATMFSLK+NEGQHPFSLSN+AAILNVDKKLKSR ELVP
Subjt:  ISQQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLLHNKHNTLSGNRVILFSYGSGSTATMFSLKLNEGQHPFSLSNIAAILNVDKKLKSRHELVP

Query:  EKFIEIMKLMEHRYGAKDFVTSKDCSLLSPGTYYLTEVDSLYRRFYAKNDGKSARFENGVVANGH
        EKF+EIMKLMEHRYGAKDF T+KDCSLL PGTYYLTEVDSLYRRFYAK DG+  + +NGVVANGH
Subjt:  EKFIEIMKLMEHRYGAKDFVTSKDCSLLSPGTYYLTEVDSLYRRFYAKNDGKSARFENGVVANGH

A0A6J1HPX8 3-hydroxy-3-methylglutaryl coenzyme A synthase

2.3e-241

89.89

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Query:  MAKNVGILAVDIYFPPTYVQQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIF
        MAKNVGILA+DIYFPPTY+QQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIF
Subjt:  MAKNVGILAVDIYFPPTYVQQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIF

Query:  EKHGNTDIEGVDSTNACYGGTAALLNCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFESRVRGSHMSHVYDFYKPNLASE
        EKHGNTDIEGVDSTNACYGGTAAL NCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAML+GPDAPI FES++RGSHMSHVYDFYKPNLASE
Subjt:  EKHGNTDIEGVDSTNACYGGTAALLNCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFESRVRGSHMSHVYDFYKPNLASE

Query:  YPVVDGKLSQTCYLMALDSCYKQLCHKYEKLEGKQFSISDADYFVFHSPYNKL-------------------IDEVAKEKLAPFSTLSGDESYQSRDLEK
        YPVVDGKLSQTCYLMALDSCYKQLCHKYEKLEGKQFSISDADYFVFHSPYNKL                   IDEVAKEKLAPFSTLS DE+YQSRDLEK
Subjt:  YPVVDGKLSQTCYLMALDSCYKQLCHKYEKLEGKQFSISDADYFVFHSPYNKL-------------------IDEVAKEKLAPFSTLSGDESYQSRDLEK

Query:  ISQQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLLHNKHNTLSGNRVILFSYGSGSTATMFSLKLNEGQHPFSLSNIAAILNVDKKLKSRHELVP
        I+QQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLLHN++N+L+GNRV+LFSYGSGSTATMFSLKLNEGQ PFSLSNI+AILNVDKKLKSRHELVP
Subjt:  ISQQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLLHNKHNTLSGNRVILFSYGSGSTATMFSLKLNEGQHPFSLSNIAAILNVDKKLKSRHELVP

Query:  EKFIEIMKLMEHRYGAKDFVTSKDCSLLSPGTYYLTEVDSLYRRFYAKNDGKSARFENGVVANGH
        EKF+EIM+LMEHRYGAKDFVTSKDCSLL  G+YYLTEVDSLYRRFYAK DG+S   EN VVANGH
Subjt:  EKFIEIMKLMEHRYGAKDFVTSKDCSLLSPGTYYLTEVDSLYRRFYAKNDGKSARFENGVVANGH

K7NBW5 3-hydroxy-3-methylglutaryl coenzyme A synthase

1.4e-254

95.91

Show/hide

Query:  MAKNVGILAVDIYFPPTYVQQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIF
        MAKNVGILAVDIYFPPTYVQQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIF
Subjt:  MAKNVGILAVDIYFPPTYVQQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIF

Query:  EKHGNTDIEGVDSTNACYGGTAALLNCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFESRVRGSHMSHVYDFYKPNLASE
        EKHGNTDIEGVDSTNACYGGTAALLNCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFESRVRGSHMSHVYDFYKPNLASE
Subjt:  EKHGNTDIEGVDSTNACYGGTAALLNCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFESRVRGSHMSHVYDFYKPNLASE

Query:  YPVVDGKLSQTCYLMALDSCYKQLCHKYEKLEGKQFSISDADYFVFHSPYNKL-------------------IDEVAKEKLAPFSTLSGDESYQSRDLEK
        YPVVDGKLSQTCYLMALDSCYKQLCHKYEKLEGKQFSISDADYFVFHSPYNKL                   IDEVAKEKLAPFSTLSGDESYQSRDLEK
Subjt:  YPVVDGKLSQTCYLMALDSCYKQLCHKYEKLEGKQFSISDADYFVFHSPYNKL-------------------IDEVAKEKLAPFSTLSGDESYQSRDLEK

Query:  ISQQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLLHNKHNTLSGNRVILFSYGSGSTATMFSLKLNEGQHPFSLSNIAAILNVDKKLKSRHELVP
        ISQQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLLHNKHNTLSGNRVILFSYGSGSTATMFSLKLNEGQHPFSLSNIAAILNVDKKLKSRHELVP
Subjt:  ISQQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLLHNKHNTLSGNRVILFSYGSGSTATMFSLKLNEGQHPFSLSNIAAILNVDKKLKSRHELVP

Query:  EKFIEIMKLMEHRYGAKDFVTSKDCSLLSPGTYYLTEVDSLYRRFYAKNDGKSARFENGVVANGH
        EKFIEIMKLMEHRYGAKDFVTSKDCSLLSPGTYYLTEVDSLYRRFYAKNDGKSARFENGVVANGH
Subjt:  EKFIEIMKLMEHRYGAKDFVTSKDCSLLSPGTYYLTEVDSLYRRFYAKNDGKSARFENGVVANGH

SwissProt top hits

e value

%identity

Alignment

P54872 Hydroxymethylglutaryl-CoA synthase A

2.1e-119

47.88

Show/hide

Query:  KNVGILAVDIYFPPTYVQQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIFEK
        +N+GI  +++YFP TYV QE LE  DG S+GKYT+GLGQ  MAFC + ED+ S+SL  V +L++K+ +DP  IGRLEVG+ETVIDKSKS+KT LM +F K
Subjt:  KNVGILAVDIYFPPTYVQQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIFEK

Query:  HGNTDIEGVDSTNACYGGTAALLNCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFESRVRGSHMSHVYDFYKPNLASEYP
        HGNT I+G+D+ NACYGGT+AL N + W+ESS WDGR  +VV  D AVY +GPARPTGGA  +AMLIGP+API FES +RG HM +VYDFYKP++ SEYP
Subjt:  HGNTDIEGVDSTNACYGGTAALLNCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFESRVRGSHMSHVYDFYKPNLASEYP

Query:  VVDGKLSQTCYLMALDSCYKQLCHKYEKLEGKQFSISDADYFVFHSPYNKLI----------------DEVAKEKLAPFSTLSGDESYQSRDLEKISQQL
         VDGKLS +CY  A+D+CY +    +EK  GK FS+   D+ +FHSPYNKL+                ++     L  +  +  +++Y    LEK    +
Subjt:  VVDGKLSQTCYLMALDSCYKQLCHKYEKLEGKQFSISDADYFVFHSPYNKLI----------------DEVAKEKLAPFSTLSGDESYQSRDLEKISQQL

Query:  AKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLLHNKHNTLSGNRVILFSYGSGSTATMFSLKLNEGQHPFSLSNIAAILNVDKKLKSRHELVPEKFIE
         K  Y  KV P+TL+ KQ+GN Y  S Y+  +SLL  K N L G RV+ FSYGSG  A+ FS K+ +      +++I   +++  +L  R  + PE F E
Subjt:  AKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLLHNKHNTLSGNRVILFSYGSGSTATMFSLKLNEGQHPFSLSNIAAILNVDKKLKSRHELVPEKFIE

Query:  IMKLMEHRYGAKDFVTSKDCSLLSPGTYYLTEVDSLYRRFYAKNDGKSA
         + L E R+  K++V S + + + PG++YL+ VD+   R Y +    SA
Subjt:  IMKLMEHRYGAKDFVTSKDCSLLSPGTYYLTEVDSLYRRFYAKNDGKSA

P54873 Hydroxymethylglutaryl-CoA synthase

4.3e-213

78.16

Show/hide

Query:  MAKNVGILAVDIYFPPTYVQQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIF
        MAKNVGILA+DIYFPPT VQQEALEAHDGASKGKYTIGLGQDC+AFCTE+EDVISMS   VTSL EKY IDP QIGRLEVGSETVIDKSKSIKTFLMQ+F
Subjt:  MAKNVGILAVDIYFPPTYVQQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIF

Query:  EKHGNTDIEGVDSTNACYGGTAALLNCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFESRVRGSHMSHVYDFYKPNLASE
        EK GNTD+EGVDSTNACYGGTAALLNCVNWVES+SWDGRYGLV+CTDSAVYAEGPARPTGGAAAIAMLIGPDAPI FES++R SHM+HVYDFYKPNLASE
Subjt:  EKHGNTDIEGVDSTNACYGGTAALLNCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFESRVRGSHMSHVYDFYKPNLASE

Query:  YPVVDGKLSQTCYLMALDSCYKQLCHKYEKLEGKQFSISDADYFVFHSPYNKL-------------------IDEVAKEKLAPFSTLSGDESYQSRDLEK
        YPVVDGKLSQTCYLMALDSCYK LC+K+EK+EGK+FSI+DADY VFHSPYNKL                   IDE AKEK  P+S+L+ DESYQSRDLEK
Subjt:  YPVVDGKLSQTCYLMALDSCYKQLCHKYEKLEGKQFSISDADYFVFHSPYNKL-------------------IDEVAKEKLAPFSTLSGDESYQSRDLEK

Query:  ISQQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLLHNKHNTLSGNRVILFSYGSGSTATMFSLKLNEGQHPFSLSNIAAILNVDKKLKSRHELVP
        +SQQ+AKP YDAKVQP+TLIPK+VGNMYTASLYAAF SL+H KHN L+G RV++FSYGSGSTATMFSL+LN+ + PFS+SNIA++++V  KLK+RHE  P
Subjt:  ISQQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLLHNKHNTLSGNRVILFSYGSGSTATMFSLKLNEGQHPFSLSNIAAILNVDKKLKSRHELVP

Query:  EKFIEIMKLMEHRYGAKDFVTSKD--CSLLSPGTYYLTEVDSLYRRFYAKNDGKSARFENGVVANGH
        EKF+E MKLMEHRYGAKDFVT+K+    LL+PGTYYL EVDSLYRRFY K      + E+G VANGH
Subjt:  EKFIEIMKLMEHRYGAKDFVTSKD--CSLLSPGTYYLTEVDSLYRRFYAKNDGKSARFENGVVANGH

P54961 Hydroxymethylglutaryl-CoA synthase 1

3.4e-117

Show/hide

Query:  NVGILAVDIYFPPTYVQQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIFEKH
        +VGI+A+++ FP  YV Q  LE +D  S GKYT+GLGQ  M FCT+ ED+ S+ LTVV+ L+E++ I   QIGRLEVG+ET++DKSKS+KT LMQ+F+  
Subjt:  NVGILAVDIYFPPTYVQQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIFEKH

Query:  GNTDIEGVDSTNACYGGTAALLNCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFESRVRGSHMSHVYDFYKPNLASEYPV
         NTDIEGVD+ NACYGGT+AL N ++WVESSSWDGRY LVV  D AVYA+G ARPTGGA A+AML+G +AP+ F+  VR SHM H YDFYKP+L+S YP 
Subjt:  GNTDIEGVDSTNACYGGTAALLNCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFESRVRGSHMSHVYDFYKPNLASEYPV

Query:  VDGKLSQTCYLMALDSCYKQLCHKYEKLEGKQFSISDADYFVFHSPYNKLI----------------DEVAKEKLAPFSTLSG---DESYQSRDLEKISQ
        VDGKLS  CYL ALD CY+  C K +K  G++F I   D  +FH+PY KL+                +E    K +    L G   +++Y  R++EK   
Subjt:  VDGKLSQTCYLMALDSCYKQLCHKYEKLEGKQFSISDADYFVFHSPYNKLI----------------DEVAKEKLAPFSTLSG---DESYQSRDLEKISQ

Query:  QLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLLHNKH-NTLSGNRVILFSYGSGSTATMFSLKL-NEGQHPFSLSNIAAIL-NVDKKLKSRHELVP
          +K +++ K +PS L+  QVGNMYT SLY   +SLL +K    L+G RV LFSYGSG  ++MFSL++ ++     SL  + + L ++  +L  RH++ P
Subjt:  QLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLLHNKH-NTLSGNRVILFSYGSGSTATMFSLKL-NEGQHPFSLSNIAAIL-NVDKKLKSRHELVP

Query:  EKFIEIMKLMEHRYGAKDFVTSKDCSLLSPGTYYLTEVDSLYRRFYAKNDG
        E+F + M+  EH +    +       +L PGT+YL  VDSLYRR Y +  G
Subjt:  EKFIEIMKLMEHRYGAKDFVTSKDCSLLSPGTYYLTEVDSLYRRFYAKNDG

Q01581 Hydroxymethylglutaryl-CoA synthase, cytoplasmic

2.4e-115

48.02

Show/hide

Query:  KNVGILAVDIYFPPTYVQQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIFEK
        K+VGI+A++IYFP  YV Q  LE +DG   GKYTIGLGQ  M FCT+ ED+ S+ +TVV +L+E+  +    IGRLEVG+ET+IDKSKS+KT LMQ+FE+
Subjt:  KNVGILAVDIYFPPTYVQQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIFEK

Query:  HGNTDIEGVDSTNACYGGTAALLNCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFESRVRGSHMSHVYDFYKPNLASEYP
         GNTDIEG+D+TNACYGGTAA+ N VNW+ESSSWDGRY LVV  D AVYA G ARPTGG  A+A+LIGP+AP+ FE  +RG+HM H YDFYKP++ SEYP
Subjt:  HGNTDIEGVDSTNACYGGTAALLNCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFESRVRGSHMSHVYDFYKPNLASEYP

Query:  VVDGKLSQTCYLMALDSCYKQLC---HKYEKLEG--KQFSISDADYFVFHSPYNKLI-------------DEVAKEK------LAPFSTLSGDESYQSRD
        +VDGKLS  CYL ALD CY   C   H   + EG  K F+++D  + +FHSPY KL+             ++  ++K      L  F  +  +++Y  RD
Subjt:  VVDGKLSQTCYLMALDSCYKQLC---HKYEKLEG--KQFSISDADYFVFHSPYNKLI-------------DEVAKEK------LAPFSTLSGDESYQSRD

Query:  LEKISQQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLL-HNKHNTLSGNRVILFSYGSGSTATMFSLKLNEGQHPFSLSN--IAAILNVDKKLKS
        +EK   + +  L+  K + S L+  Q GNMYT+S+Y +  S+L       L+G R+ +FSYGSG  AT++SLK+ +   P S  +   A++ ++  +L S
Subjt:  LEKISQQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLL-HNKHNTLSGNRVILFSYGSGSTATMFSLKLNEGQHPFSLSN--IAAILNVDKKLKS

Query:  RHELVPEKFIEIMKLMEHRYGAKDFVTSKDCSLLSPGTYYLTEVDSLYRRFYAK
        R  + P+ F E MKL E  +   +++       L  GT+YL  VD  +RR YA+
Subjt:  RHELVPEKFIEIMKLMEHRYGAKDFVTSKDCSLLSPGTYYLTEVDSLYRRFYAK

Q5R7Z9 Hydroxymethylglutaryl-CoA synthase, cytoplasmic

1.8e-115

48.02

Show/hide

Query:  KNVGILAVDIYFPPTYVQQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIFEK
        K+VGI+A++IYFP  YV Q  LE +DG + GKYTIGLGQ  M FCT+ ED+ S+ +TVV +L+E+  +    IGRLEVG+ET+IDKSKS+KT LMQ+FE+
Subjt:  KNVGILAVDIYFPPTYVQQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIFEK

Query:  HGNTDIEGVDSTNACYGGTAALLNCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFESRVRGSHMSHVYDFYKPNLASEYP
         GNTDIEG+D+TNACYGGTAA+ N VNW+ESSSWDGRY LVV  D AVYA G ARPTGG  A+A+LIGP+AP+ FE  +RG+HM H YDFYKP++ SEYP
Subjt:  HGNTDIEGVDSTNACYGGTAALLNCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFESRVRGSHMSHVYDFYKPNLASEYP

Query:  VVDGKLSQTCYLMALDSCYKQLCHKYE---KLEG--KQFSISDADYFVFHSPYNKLI-------------DEVAKEK------LAPFSTLSGDESYQSRD
        +VDGKLS  CYL ALD CY   C K     + EG  K F+++D  + +FHSPY KL+             ++  ++K      L  F  +  +++Y  RD
Subjt:  VVDGKLSQTCYLMALDSCYKQLCHKYE---KLEG--KQFSISDADYFVFHSPYNKLI-------------DEVAKEK------LAPFSTLSGDESYQSRD

Query:  LEKISQQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLL-HNKHNTLSGNRVILFSYGSGSTATMFSLKLNEGQHPFSLSN--IAAILNVDKKLKS
        +EK   + +  L+  K + S L+  Q GNMYT+S+Y +  S+L       L+G R+ +FSYGSG  AT++SLK+ +   P S  +   A++ ++  +L S
Subjt:  LEKISQQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLL-HNKHNTLSGNRVILFSYGSGSTATMFSLKLNEGQHPFSLSN--IAAILNVDKKLKS

Query:  RHELVPEKFIEIMKLMEHRYGAKDFVTSKDCSLLSPGTYYLTEVDSLYRRFYAK
        R  + P+ F E MKL E  +   +++       L  GT+YL  VD  +RR YA+
Subjt:  RHELVPEKFIEIMKLMEHRYGAKDFVTSKDCSLLSPGTYYLTEVDSLYRRFYAK

Arabidopsis top hits

e value

%identity

Alignment

AT4G11820.1 hydroxymethylglutaryl-CoA synthase / HMG-CoA synthase / 3-hydroxy-3-methylglutaryl coenzyme A synthase

2.3e-182

76.21

Show/hide

Query:  MSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIFEKHGNTDIEGVDSTNACYGGTAALLNCVNWVESSSWDGRYGLVVCTDSAVYAEGP
        MS   VTSL EKY IDP QIGRLEVGSETVIDKSKSIKTFLMQ+FEK GNTD+EGVDSTNACYGGTAALLNCVNWVES+SWDGRYGLV+CTDSAVYAEGP
Subjt:  MSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIFEKHGNTDIEGVDSTNACYGGTAALLNCVNWVESSSWDGRYGLVVCTDSAVYAEGP

Query:  ARPTGGAAAIAMLIGPDAPIAFESRVRGSHMSHVYDFYKPNLASEYPVVDGKLSQTCYLMALDSCYKQLCHKYEKLEGKQFSISDADYFVFHSPYNKL--
        ARPTGGAAAIAMLIGPDAPI FES++R SHM+HVYDFYKPNLASEYPVVDGKLSQTCYLMALDSCYK LC+K+EK+EGK+FSI+DADY VFHSPYNKL  
Subjt:  ARPTGGAAAIAMLIGPDAPIAFESRVRGSHMSHVYDFYKPNLASEYPVVDGKLSQTCYLMALDSCYKQLCHKYEKLEGKQFSISDADYFVFHSPYNKL--

Query:  -----------------IDEVAKEKLAPFSTLSGDESYQSRDLEKISQQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLLHNKHNTLSGNRVILF
                         IDE AKEK  P+S+L+ DESYQSRDLEK+SQQ+AKP YDAKVQP+TLIPK+VGNMYTASLYAAF SL+H KHN L+G RV++F
Subjt:  -----------------IDEVAKEKLAPFSTLSGDESYQSRDLEKISQQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLLHNKHNTLSGNRVILF

Query:  SYGSGSTATMFSLKLNEGQHPFSLSNIAAILNVDKKLKSRHELVPEKFIEIMKLMEHRYGAKDFVTSKD--CSLLSPGTYYLTEVDSLYRRFYAKNDGKS
        SYGSGSTATMFSL+LN+ + PFS+SNIA++++V  KLK+RHE  PEKF+E MKLMEHRYGAKDFVT+K+    LL+PGTYYL EVDSLYRRFY K     
Subjt:  SYGSGSTATMFSLKLNEGQHPFSLSNIAAILNVDKKLKSRHELVPEKFIEIMKLMEHRYGAKDFVTSKD--CSLLSPGTYYLTEVDSLYRRFYAKNDGKS

Query:  ARFENGVVANGH
         + E+G VANGH
Subjt:  ARFENGVVANGH

AT4G11820.2 hydroxymethylglutaryl-CoA synthase / HMG-CoA synthase / 3-hydroxy-3-methylglutaryl coenzyme A synthase

3.0e-214

78.16

Show/hide

Query:  MAKNVGILAVDIYFPPTYVQQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIF
        MAKNVGILA+DIYFPPT VQQEALEAHDGASKGKYTIGLGQDC+AFCTE+EDVISMS   VTSL EKY IDP QIGRLEVGSETVIDKSKSIKTFLMQ+F
Subjt:  MAKNVGILAVDIYFPPTYVQQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIF

Query:  EKHGNTDIEGVDSTNACYGGTAALLNCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFESRVRGSHMSHVYDFYKPNLASE
        EK GNTD+EGVDSTNACYGGTAALLNCVNWVES+SWDGRYGLV+CTDSAVYAEGPARPTGGAAAIAMLIGPDAPI FES++R SHM+HVYDFYKPNLASE
Subjt:  EKHGNTDIEGVDSTNACYGGTAALLNCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFESRVRGSHMSHVYDFYKPNLASE

Query:  YPVVDGKLSQTCYLMALDSCYKQLCHKYEKLEGKQFSISDADYFVFHSPYNKL-------------------IDEVAKEKLAPFSTLSGDESYQSRDLEK
        YPVVDGKLSQTCYLMALDSCYK LC+K+EK+EGK+FSI+DADY VFHSPYNKL                   IDE AKEK  P+S+L+ DESYQSRDLEK
Subjt:  YPVVDGKLSQTCYLMALDSCYKQLCHKYEKLEGKQFSISDADYFVFHSPYNKL-------------------IDEVAKEKLAPFSTLSGDESYQSRDLEK

Query:  ISQQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLLHNKHNTLSGNRVILFSYGSGSTATMFSLKLNEGQHPFSLSNIAAILNVDKKLKSRHELVP
        +SQQ+AKP YDAKVQP+TLIPK+VGNMYTASLYAAF SL+H KHN L+G RV++FSYGSGSTATMFSL+LN+ + PFS+SNIA++++V  KLK+RHE  P
Subjt:  ISQQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLLHNKHNTLSGNRVILFSYGSGSTATMFSLKLNEGQHPFSLSNIAAILNVDKKLKSRHELVP

Query:  EKFIEIMKLMEHRYGAKDFVTSKD--CSLLSPGTYYLTEVDSLYRRFYAKNDGKSARFENGVVANGH
        EKF+E MKLMEHRYGAKDFVT+K+    LL+PGTYYL EVDSLYRRFY K      + E+G VANGH
Subjt:  EKFIEIMKLMEHRYGAKDFVTSKD--CSLLSPGTYYLTEVDSLYRRFYAKNDGKSARFENGVVANGH

Sequences

Show/hide sequences

CDS sequence

Show/hide CDS sequence

ATGGCTAAGAATGTGGGAATTCTCGCTGTCGATATCTACTTCCCTCCTACGTACGTTCAGCAGGAAGCATTGGAAGCTCATGATGGTGCAAGCAAGGGGAAATACACTAT
TGGGCTCGGACAGGATTGCATGGCATTCTGCACTGAGGTTGAAGATGTCATCTCAATGAGCTTGACAGTTGTCACTTCCCTTCTTGAGAAATATGGAATTGATCCAAAAC
AAATTGGTCGGCTTGAAGTAGGCAGTGAGACTGTTATAGATAAAAGTAAATCAATTAAGACTTTCCTGATGCAAATATTTGAGAAACATGGAAATACCGATATTGAAGGT
GTTGATTCGACTAATGCGTGCTATGGGGGTACAGCTGCTCTATTAAACTGTGTCAATTGGGTAGAGAGCAGCTCTTGGGATGGGCGTTATGGTCTTGTGGTGTGCACAGA
TAGTGCGGTCTATGCTGAAGGGCCAGCTCGTCCTACTGGTGGGGCTGCAGCTATTGCCATGCTTATAGGACCTGATGCTCCTATTGCTTTTGAAAGCAGAGTGAGGGGAA
GTCATATGTCACACGTCTATGATTTTTACAAGCCTAACCTAGCCAGTGAATACCCGGTGGTTGATGGTAAGCTCTCTCAAACCTGTTACCTCATGGCCCTGGATTCTTGC
TATAAGCAATTATGTCATAAGTATGAGAAACTGGAGGGCAAACAATTTTCTATTTCTGATGCTGACTATTTTGTATTTCATTCTCCCTATAACAAGCTCATAGATGAAGT
TGCTAAAGAAAAGCTGGCACCATTTTCAACCTTGTCTGGTGATGAAAGTTACCAGAGTCGGGATCTCGAAAAGATATCTCAACAACTTGCAAAACCTCTTTATGATGCAA
AGGTGCAACCCTCTACTTTAATACCAAAGCAAGTTGGGAACATGTATACTGCCTCTCTTTATGCAGCATTTATATCACTTCTTCACAACAAGCATAACACACTGTCAGGA
AATAGGGTGATATTGTTCTCTTATGGAAGCGGTTCGACTGCAACAATGTTCTCATTGAAACTCAATGAAGGTCAACATCCCTTTAGTTTGTCCAACATTGCAGCTATTTT
GAATGTGGATAAAAAGTTGAAATCGAGGCATGAGTTGGTTCCCGAAAAGTTCATCGAAATAATGAAGCTGATGGAGCATAGGTACGGGGCCAAGGATTTCGTGACGAGCA
AGGACTGCAGCCTTCTATCACCCGGCACCTACTATCTCACTGAAGTCGATTCTTTGTACAGGAGATTCTACGCCAAGAACGACGGCAAAAGTGCAAGGTTTGAGAATGGT
GTGGTTGCTAATGGCCATTGA

mRNA sequence

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Protein sequence

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MAKNVGILAVDIYFPPTYVQQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIFEKHGNTDIEG
VDSTNACYGGTAALLNCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFESRVRGSHMSHVYDFYKPNLASEYPVVDGKLSQTCYLMALDSC
YKQLCHKYEKLEGKQFSISDADYFVFHSPYNKLIDEVAKEKLAPFSTLSGDESYQSRDLEKISQQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLLHNKHNTLSG
NRVILFSYGSGSTATMFSLKLNEGQHPFSLSNIAAILNVDKKLKSRHELVPEKFIEIMKLMEHRYGAKDFVTSKDCSLLSPGTYYLTEVDSLYRRFYAKNDGKSARFENG
VVANGH

Sgr022035 (gene) of Monk fruit (Qingpiguo) v1 genome